MOISTURIZING

aquaxtrem
TM
Activates the
own mechanisms
of the skin for a
long-lasting
moisturization
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is obtained from the
roots of rhubarb
(Rheum rhaponticum).
We used an in silico
screening to evaluate
and select rhaponticin,
a molecule present in
rhubarb that ats as a
natural agonist of
PPARy.
aquaxtrem
TM
Keratinocytes, during the
differentiation process, are
responsible for the production of
elements of these structures, such as:
aquaxtrem
TM
Stimulates barrier function and skin
hydration from the inside
Boosts keratinocyte differentiation
By activating PPARy, receptor that
controls gene expression of different
cells, aquaxtrem
TM
:
Lipids of cutaneous barrier
Involucrin
Filaggrin
Natural moisturizing factor (NMF)
Cutaneous barrier
The skin has mechanisms and
structures designed to maintain
the hydration:
Activates the own mechanisms of the skin for a long-lasting moisturization
aquaxtrem
TM
Hydration is key
As years go by, keratinocyte movement
slows down and skin becomes dry, weak
and aged.
works from the inside, stimulating
hydration mechanisms of the skin,
through the activation of PPARy
D29S4
vs
D29S
aquaxtrem
TM
reduces water loss (TEWL)
repairing the barrier function.
TEWL evaluation
25
20
15
10
5
0
P
E
R
C
E
N
T
A
G
E
aquaxtrem
TM
improves natural mechanisms
involved in the barrier function and provides a
deep and long-lasting hydration.
Hydration evaluation
CERF TOTAL
LIPIDS
PERCENTAGE OF LIPIDS VS. CONTROL
400
300
200
100
0
P
E
R
C
E
N
T
A
G
E
Improvement of skin barrier
* RH 5 (rhaponticin 5 ppm); RH 25 (rhaponticin 25 ppm)
Stratum corneum resistance and cohesion
Improvement of barrier function
Recovery of skin hydration
Effects of rhaponticin on human epidermal
keratinocytes were analysed to prove its
capacity of modulating laggrin and involucrin
production, key elements for stratum corneum.
The more fluorescence intensity, the more
filaggrin and involucrin levels:
In vivo study protocol
In vitro efcacy
MOISTURIZING
In vivo efcacy
Increase of stratum corneum cohesion
CHOLES-
TEROL
FREE FATTY
ACIDS
CHOLES-
TERYL
ESTERS
Rhaponticin (RH 5) increases production of
barrier lipids, thus protects the body and
avoids skin dehydration.
Barrier recovery
Accumulated hydration
Cohesion
Start treatment
D0 Barrier (TEWL)
Hydration
Cohesion

D1
End treatment D28
D29
D31 Long-lasting hydration
+9.6%
+11.6%
D29 D31
PLACEBO aquaxtrem
TM
-14.13%
-7.13%
* D29S (after stripping); D29S4 (4h after stripping)
-15 -10 -5 0
D29
vs
D0
I
N
V
O
L
U
C
R
I
N
RH25 RH5 NIACINAMIDE CONTROL
I
N
T
E
N
S
I
T
Y
600
500
400
300
200
100
0
+37%
+32%
+62%
RH25 RH5 NIACINAMIDE CONTROL
F
I
L
A
G
G
R
I
N
350
300
250
200
150
100
50
0
+36%
+20%
+59%
I
N
T
E
N
S
I
T
Y
25 women between 40-57 years old, with dry skin. Placebo and
aquaxtrem
TM
(1.5%) on arms and legs, twice daily for 28 days.
PERCENTAGE OF aquaxtrem
TM
VS. PLACEBO
Transparent liquid
Brown - dark brown color
Mango - ECO G
Bismuth Oxychloride, Mica, Iron Oxides (CI
77491)
F
Polysorbate 20
Parfum (Fragrance)
Glycerin, Leuconostoc/Radish Root Ferment
Filtrate, Lonicera Japonica (Honeysuckle)
Flower Extract, Lonicera Caprifolium
(Honeysuckle) Extract, Populus Tremuloides
Bark Extract, Gluconolactone
E
D Aqua (Water), Sodium Hydroxide
C
B
Polymethyl Methacrylate, Sodium Acrylate/
Sodium Acryloyl Dimethyl Taurate Copolymer,
Isohexadecane
Alcohol Denat.
aquaxtrem
TM
Aqua (Water)
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
A
INCI / PCPC
1.00
0.03
0.50
0.15
1.75
1.20
2.00
10.00
1.50
81.27
0.60
% (w/w)
RECOMMENDED DOSE
SOLUBILITY
APPEARANCE
ACTIVE MOLECULES
0.5 - 1.5 %
Soluble in aqueous solutions
Rhaponticin
Stimulates the skin natural
mechanisms of hydration through
the activation of PPARy
PROPERTIES
Activates the own mechanisms of the skin for a long-lasting moisturization
aquaxtrem
TM
MOISTURIZING
In vivo efcacy
Evaluation of skin dryness and stratum corneum cohesion (microscope images)
D0 D29
cosmetic applications
aquaxtrem
TM
normalizes stratum corneum
desquamation, stimulating differentiation
of keratinocytes and natural hydration
mechanisms.
Technical specications Formulation
Facial and body care (shower gel, body milk, hand cream)
Specific treatments for dry, very damaged or mature skin
Hair care (shampoos, lotions, conditioners, masks)
Make-up
Sun care products
aquaxtrem
TM
75680 Perfect Moisture Gel
V01-2013