Propolis and it's effects on fungus or candida

What is Candida?
Candida is a form of parasitic fungus which resemble yeasts and occur
especially in the mouth, vagina, and intestinal tract. Though usually
benign, they can become pathogenic, causing diseases including
candidiasis and thrush.
The List of Studies on the Effects of Propolis on Candida
1) *Effect of commercial ethanol propolis extract on the in vitro
growth of Candida albicans collected from HIV-seropositive and
HIV-seronegative Brazilian patients with oral candidiasis.*
*Authors:*Martins RS; Preira ES; Lima SM; Senna MI; Mesquita RA; Santos VR
Department of Clinical Pathology and Surgery, School of Dentistry, Minas
Gerais Federal University, Belo Horizonte, Brazil.
*Summary of Research:
*The present study assessed the susceptibility of Candida albicans
strains, collected from HIV-positive patients with oral candidiasis, to
a commercial 20% ethanol propolis extract (EPE) and compare it to the
inhibitory action of the standardized antifungal agents nystatin (NYS),
clotrimazole (CL), econazole (EC), and fluconazole (FL).
Twelve C. albicans strains collected from HIV-positive patients with
oral candidiasis were tested. The inhibition zones were measured with a
pachimeter and the results are reported as means and standard deviation
(M +/- SD).
Data were analyzed statistically by the non-parametric Kruskal-Wallis
test. EPE inhibited all the C. albicans strained tested. No significant
difference was observed between the results obtained with NYS and EPE,
while significant differences were observed between EPE and other
antifungals.
The C. albicans strains tested showed resistance to the remaining
antifungal agents. The propolis extract used in this study inhibited the
in vitro growth of C. albicans collected from HIV-seropositive Brazilian
patients, creating/forming inhibition zones like those ones formed by NYS.
This fact suggests that commercial EPE could be an alternative medicine
in the treatment of candidiasis from HIV-positive patients. However, in
vivo studies of the effect of EPE are needed to determine its possible
effects on the oral mucosa.
*Journal:* Juornal of Oral Science
*Issue:* 2002 Mar;44(1):41-8.
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2) *Seasonal Effect of Brazilian Propolis on Candida albicans AND
Candida tropicalis*
*Authors: *J. M. SFORCIN,A. FERNANDES JNIOR, C. A. M. LOPES, S. R. C.
FUNARI, V. BANKOVA
*1*. Departamento de Microbiologia e Imunologia, Instituto de
Biocincias, Universidade Estadual Paulista, Botucatu, So Paulo, Brasil;
*2* Institute of Organic Chemistry with Centre of Phytochemistry,
Bulgarian Academy of Sciences, 1113, Sofia, Bulgaria.
*Summary of Research:
*Recently, propolis has been attracting the attention of researchers due
to various biological activities and therapeutic properties. In Brazil,
propolis is produced all year long, so there may be some seasonal
variations.
This work was carried out in order to compare propolis collected during
the four seasons by its/ in vitro/ antimicrobial activity on yeast
pathogens isolated from human infections. Propolis was produced by
africanized honeybees in Botucatu, So Paulo State, collected throughout
a year and pooled by season.
Hydroalcoholic solutions of propolis were prepared with each pool and
diluted in agar, using serial concentrations of propolis from each pool.
A determination of minimal inhibitory concentration (MIC) was performed.
The results show that/ Candida/ tropicalis and/ Candida/ albicans were
susceptible to low concentrations of propolis, the latter showing a
higher susceptibility. No differences were seen in relation to seasonal
effects in the minimal inhibitory concentration of propolis.
*Journal:* Journal of Venomous Animals and Toxins
*Issue:* v.7 n.1 Botucatu 2001
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3) *Antifungal activity of propolis on different species of Candida*
*Authors: * Claudia Ota, Carmelinda Unterkircher, Vera Fantinato, M. T.
Shimizu
Dental School, UNESP, So Jos dos Campos, SP, University of Vale do
Paraba, IP & D, and Pharmacy School, So Francisco University, USF,
Bragana Paulista, SP, Brasil.
*Summary of Research:
*Propolis is a resinous material collected by bees from the buds or
other parts of plants. It is known for its biological properties, having
antibacterial, antifungal and healing properties.
The antifungal activity of propolis was studied in sensitivity tests on
80 strains of Candida yeasts: 20 strains of Candida albicans, 20
strains of Candida tropicalis, 20 strains of Candida krusei and 15
strains of Candida guilliermondii.
The yeasts showed a clear antifungal activity with the following order
of sensitivity: C. albicans C. tropicalis C. krusei C.
guilliermondii.
Patients with full dentures who used a hydroalcoholic propolis extract
showed a decrease in the number of /Candida/.
*Journal:* Mycoses
*Issue:* Volume 44 Issue 9-10 Page 375 November 2001
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4) *The effect of Brazilian Propolis on the germ tube formation
and cell walls of Candida Albicans*
*Authors: * Andr Marinho Mello, Rafael Tomaz Gomes, Simone Resende
Lara, L. Gomes Silva, Jos Bento Alves, Maria Esperanza Corts, Sheila
Lemos Abreu, Vagner Rodrigues Santos. .
*Summary of Research:
*Candidal adherence has been implicated as the first step in the
pathogenesis of oral
candidosis, and germ tube formation by Candida albicans has been
attributed as co-factor that promotes adherence.
Propolis, a natural product produced by the honeybee, has been shown to
possess antifungal activity although the mechanism of its action remains
unclear.
The aim of this study was to investigate the germ tube formation
capacity of C.albicans (ATCC18804) following its exposure to Brazilian
Green Propolis (BGP) at different concentrations. The ultrastructural
topographic features of the yeast cells exposed to propolis using
transmission electron microscopy (TEM) and light microscopy (LM) were
performed to investigate the morphology of the yeast. Yeast cell
suspensions were added to tubes containing foetal calf serum medium (2
h-37C). Nystatin and C. glabrata (ATCC 2001) were used as control.
Absence of germ tube formation (LM) occurred at 0,33 g/mL. The
ultrastructural findings (TEM) showed hyperplasia and changes in the
cell surface at 0,43 g/mL . It is suggested that the antifungal
activity of propolis is due to changes in the cell wall leading to an
increase of volume and membrane rupture. The positive results suggest
that propolis should be further tested as an alternative therapy for
infectious conditions of the oral cavity, such candidiasis
and denture stomatitis.
*Journal:* Pharmacologyonline
*Issue:* Archive 29
2 Responses to /Propolis and it's effects on fungus or candida/
1.
Susan Di Santo
April 3, 2011 at 4:44 pm

I suffered from frequent cyctitis, brought on by stress. The back
to back infections and doses of antibiotic treatment brought on
gut problems I didn't relate the concurrent frequent athletes
foot, ringworm, fungal toenails infections, ocassional oral &
vaginal thrush, ear itchiness, vison irregularities and eventually
hip joint pain, bourts of depression and brain fog until a friend
pointed me to leaky gut & systemic candida. I got rid of the skin
stuff & nails with tea tree, lavender oil & sea salt,citrcidal
particularly for bathing etc. I sucked then swallowed raw propolis
when on holiday where fammily in Italy keep bees, while I ate lots
of garlic and lemon juice, no wheat and dairy. After aboput 2
weeks I noiced headaches (Herxheimer reaction from detoxing) and a
dark red itchy rash down the inside of my upper arms candida
leaving my body? I think so. I also stayed off wine , vinegar and
yeasty foods as well as mushrooms. After a couple of months I took
some high quality probiotic supplements freeze dried, no FOS added
(brand VSL#3)If it's not kept in the fridge and sold in brown
glass or foil sealed pack do not buy, it's rubbish. Other things
for candida internal blitz is a 2month diet started if you can
with a 3 day juice fast & using enemas for colon clear out, trying
the following oral antifunals: Coconur oil, citricidal, oregano
oil, Pau D'Arco, olive leaf complex, chlorella. Learn about body
PH and what keeps your body PH low in foods. This helps to kill
off candida. Be prepared to feel low and a bit ill and liverish
while you detox Candida die-off. introduce brown rice buckwheat
carb alternatives when you start to lose weight and need energy.
maybe dairy and more meat. Take EFA Omegas 3, lots of greens,
nori, avocados, raw as much as poss. little fish and tofu.
Almonds, pumkin, sesame, sunflower & chia seeds. Cracked flax and
hemp seeds all in salads, (few crushed walnuts are nice too).
Learn about calcium, potassium & magnesium and unrefined celtic
sea salt. Salt free can be bad almost as bad as refined salty
diet. Keep practicing a good diet habits. stay off alcohol, but if
you really must for occasional social things, vodka with fresh
lemon or tomato is not the worst. (for me wine always brought back
cystitis symptoms intitially so I've stayed off it). It's hard but
if you are determined to get rid of Candida you will feel so much
better, fit and alive.
Reply

2.
Charles Giltner
October 14, 2010 at 8:07 pm

The use of propolis in humans seems to have a long and positive
history and I am interested in learning about how to actually
administer it as a most effective form of treatment for internal
candida albicans overgrowth presenting in toenail fungus and
ringworm as well as periodontal infection and immune response as
well as overall beneficial use for improved health. In this light,
I have purchased some unprocessed raw honey with beeswax, propolis
and enzymes and would like some feedback on how to dose, apply or
administer the honey either orally, ingested or topically in this
form or with little processing. Please respond to this comment by
email to Charlesgiltner@live.com <mailto:Charlesgiltner@live.com>
Thanks
cg
Also, it would be interesting to learn if there is a way to
artificially reproduce propolis either chemically or by natural
harvesting and processing of the source of the propolis
ingredients from the plant sources sidestepping the bees. I am
sure this is a tall order, but it would prove to be a popular
product in our current and future environmental and health care
circumstances. As global warming increases, microbiological
organisms will increase in geometrically proportionate fashion.
This will have a tremendous effect on human health, animal
husbandry, agriculture and civilization as a whole since the
effective control of many of the microbiological entities is
limited at best. An effective alternative to antibiotic medicines
that destroy intestinal flora would be a benefit to all mankind.
Any takers on this line of thinking or is there already studies
and attempts at this lofty goal? I'd like your thought, whoever
you are reading this! Best wishes and great information on the
site. KUTGOW (Keep up the good work!)
Reply