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Pathophysiology of Chronic Glomerulonephritis





PRIMARY CAUSES
Unknown
Direct glomerular
damage
SECONDARY CAUSES
SLE, Good pastures,
Infection
Damage to the glomerular
membrane
Release of inflammatory
mediators
Lodging of antigen-antibody
complexes in the glomerular
membrane
Inflammation
Fibrosis, scarring, sclerosis
of the glomerulus

Decrease in glomerular
filtration rate
Renal failure Hyperpermeability of the
glomerular membrane
Decreased urinary output,
Edema, Hypertension
Sodium and water
retention
Increased urinary
frequency, proteinuria,
albuminuria, hematuria
Fatigue, difficulty of
breathing, anemia,
nausea and vomiting
Congestive heart failure,
Pulmonary edema
Dark frothy urine
Diuretics
Angiotensin Converting
Enzyme Inhibitors,
Amgiotensin II receprotr
blockers for hypertension
Diet modifications: low
salt, low fat, low protein
diet. Fluid restrictions as
advised
LEGEND:
Causes
Disease process
Reaction/compensation
Signs and symptoms
Complications
Treatment and management
Pain and
tenderness
on the back

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