EBME 421 BIOELECTRIC PHENOMENA

Fall 2014
3 credits
Catalog Data: Models of excitable cells and membranes. Neural
and Cardiac action potentials. Propagation of
excitation. Bioelectric sources, volume conductor
felds. Electric Field interaction wit excitable
tissue. Electrical stimulation. Neural recording.
Textbook: Barr and !. Plonse", Bioelectricit"# a $uantitative
%pproac, &xford, '
rd
edition
The textbook can be downloaded from:
http://rave.ohiolink.edu/ebooks/ebc/9780387488653
(elected fundamental )ournal articles
Reference: No formal supplemental references are used.
Website: Blac*board
Coordinator: +omini,ue M. +urand
Instructors: +omini,ue +urand -+M+. -BME., /ennet 0aurita
-/!0.
Teaching Assistant 1omas Eggers tee8@case.edu
Goal: 1e goal of tis course is to provide wor*ing
*nowledge of te teoretical metods tat are
used in te felds of electrop"siolog" and
Bioelectricit" for bot neural and cardiac s"stems.
1ese metods will be applied to describe, from a
teoretical and ,uantitative perspective, te
electrical beavior of excitable cells, te metods
for recording teir activit" and te e2ect of applied
electrical and magnetic felds on excitable tissues.
Recommended preparation: +i2erential e,uations, Circuits
rere!uisite: 3raduate standing or 4ndergraduate wit senior
standing and cumulative 3P% of '.5 or
above.
Time: "onda#s and Wednesda#s at $:%%
&ocation: Wickenden '%(
rere!uisites b# Topic: +i2erential e,uations
P"siolog" -or concurrent.
Circuits
Grading polic#: 6ee*l" -not 6ea*l". 7omewor*# -589.
Midterm Examination# -589.
Final Examimation# -589.
Modelling Pro)ect# -589.
DAT) &ecture Reference ro
f
Con*icts
%+,-(,-%'
.
/istor# of 0ioelectromagnetism /andout 1R& D"D
)0"2
%+,-3,-%'
.
Acti4e beha4ior of the cell
:oltage clamp metod
Non;linear membrane beavior
:oltage clamp<7odg*in;7uxle" model
Patc clamp<Mar*ov Modeling
Textbook:
Chapter .5
( and Class
6otes
1R& D"D
)"02
%$,',-%'. &abor Da#
%$,7,-%'.
Action potential currents,properties
Class 6otes 1R& 6eural
)ng
&ondon
%$,+,-%'. Action potential propagation
Core conductor e,uations
6ave e,uation
Cardiac impulse propagation
Textbook:
Chapter 8
and Class
6otes
1R& 6eural
)ngineeri
ng &ondon
%$,'%,-%'
.
6ormal cardiac electroph#siolog#
Abnormal cardiac electroph#siolog#
Class 6otes 1R& 6eural
)ng
&ondon
%$,'(,-%'
.
6euroscience Re4iew 6euroh#sio
l9
Introduction
D"
D
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2ubthreshold phenomena
Nernst;e,uation
Nernst;Planc* e,uation
&rigin of te resting potential
1e +onnan e,uilibrium
Constant;feld;membrane model
Membrane conductivit" and rectifcation
%ctive 1ransport
Textbook:
chapter7
D"
D
%$,--,-%'
.
Cable Theor# I Rall D"
D
%$,-.,-%'
.
Cable Theor# II Rall D"
D
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.
Cable assi4e Transient Response
ro:ect proposal due
Rall;6otes D"
D
'%,%',-%'
.
<ector Anal#sis
3radient;divergence;Curl;0aplacian
3auss 1eorem;3reen 1eorem
Textbook:
Chapter'
D"
D
'%,8,-%'. <olume conductors
1e uman bod" as a volume conductor
$uasi;static formulation of Maxwell
e,uations
lonse#
lonse#
D"
D
'%,+,-%'.
/omogeneous media 2olutions I
6une= D"
D
'%,'7,-%'
.
/omogeneous media 2olutions II
6une= D"
D
'%,'(,-%'
.
"idterm )xamination >In?class@ D"
D
'%,-%,-%'
.
Inhomogenous and Anisotropic
media
6une= D"
D
'%,--,-%'
.
Conducti4it# measurements Class notes D"
D
'%,-3,-%'
.
Aall 0reak 6I/
Re4iew
'%,-$,-%'
.
2timulation of 6eural Tissue
Membrane polari=ation (Ranck: Electrical
Stimulation)
%ctivation Function# M"elinated and
unm"linated fbers
Electrical (timulation (imulation (McNeil:
IEEE Article)
(trengt duration Curve
Ranck D"
D
'',%7,-%'
.
)xtracellular Belds for known cardiac
source
Fiber
(olid angle
Macroscopic cardiac sources
Textbook:
Chapter +
and Class
6otes
1R& 0<A
Australia
'',%(,-%'
.
"idterm Report >in class@ D"D 0<A
Australia
'','%,-%'
.
)xtracellular Belds for unknown cardiac
source
3auss<3reens teorem
(ingle cell
Class 6otes 1R&
'','-,-%'
.
Aorward problem >)CG@
(econdar" sources
1issue eterogeneities
>nverse solution
Class 6otes 1R&
'','3,-%'
.
6et Dri4ing Aunction Warman D"
D
D"D 2A6
'','$,-%'
.
Acti4ation Aunction# M"elinated and
unm"elinated fbers (Rattay: Electrical Nerve
Stimulation) and net driving function:
Warman et al.
Ratta# D"
D
'',-.,-%'
.
"agnetic stimulation
Magnetic stimulation -Basser and !ot#
>EEE%rticle.ttp#<<www.biomag.us.f<tms
<1esis<dt.tml?5.
0asser and
RothC
6agara:anC
Durand
/andout
D"
D
'',-8,-%'
.
0iopotential recording
Field of single cell
Potentials from e,uivalent sources
1ransmembrane potential as a source
function
(econdar";source representation of
volume;conductor inomogeneities
Textbook
Chapter 3:
D"
D
'-,',-%'.
6er4e Recording (Stein: Nerve and
muscles)
2tein: 6er4e
and "uscle
D"
D
'-,%7,-%'
.
Current?source anal#sis Dohnston
and WuC
6icholson
D"
D
'-,%.,-%'
7
Ainal )xamination >in?class@
'-,'(,-%'
7
+:7%?'':7% ro:ect resentations
'-,'$,-%'
7
Grades due