05-09-2014

05
th
September, 2014 Volume No.: 37 Issue No.: 02
Vision
TO REACH THE PINNACLE OF GLORY AS A CENTRE OF EXCELLENCE IN THE FIELD
OF PHARMACEUTICAL AND BIOLOGICAL SCIENCES BY KNOWLEDGE BASED
LEARNING AND PRACTICE
Contents
Message from PRINCIPAL
Editorial board
Historical article
News Update
Knowledge based Article
Disease Related Breaking
News
Upcoming Events
Drugs Update
Campus News
Students Section
Editors Note
Archive
GNIPST Photo Gallery
For your comments/contribution
OR For Back-Issues,
mailto:gnipstbulletin@gmail.com
GURU NANAK INSTITUTE OF PHARMACEUTICAL
SCIENCE AND TECHNOLOGY

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05-09-2014
MESSAGE FROM PRINCIPAL

"It can happen. It does happen.
But it can't happen if you quit." Lauren Dane.
We are what we repeatedly do.
Excellence then is not an act, but a habit. Aristotle
It gives me immense pleasure to pen a few words for our e-bulletin. At the onset I would like to thank the
last years editors and congratulate the newly selected editors for the current year.
Our first consideration is always in the best interest of the students. Our goal is to promote academic
excellence and continuous improvement.
I believe that excellence in education is aided by creating a learning environment in which all learners are
supported in maximizing their potential and talents. Education needs to focus on personalized learning
and instruction, while promoting an education system that is impartial, universally accessible, and meeting
the needs of all students.
It is of paramount importance that our learners have sufficient motivation and encouragement in order to
achieve their aims. We are all very proud of you, our students, and your accomplishments and look
forward to watching as you put your mark on the profession in the years ahead.
The call of the time is to progress, not merely to move ahead. Our progressive Management is looking
forward and wants our Institute to flourish as a Post Graduate Institute of Excellence. Steps are taken in
this direction and fruits of these efforts will be received by our students in the near future. Our Teachers
are committed and dedicated for the development of the institution by imparting their knowledge and play
the role of facilitator as well as role model to our students.
The Pharmacy profession is thriving with a multitude of possibilities, opportunities and positive
challenges. At Guru Nanak Institute of Pharmaceutical Science and Technology, our focus is on holistic
needs of our students.
I am confident that the students of GNIPST will recognize all the possibilities, take full advantage of the
opportunities and meet the challenges with purpose and determination.
Excellence in Education is not a final destination, it is a continuous walk. I welcome you to join us on
this path.
My best wishes to all.
Dr. A. Sengupta
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05-09-2014
EDITORIAL BOARD
CHIEF EDITOR DR. ABHIJIT SENGUPTA
EDITOR MS. JEENATARA BEGUM
ASSOCIATE EDITOR MR. DIPANJAN MANDAL
HISTORICAL ARTICLE
History of Teachers Day in India:
While the world celebrates international Teachers Day on the 15th
of October, India celebrates it on the 5th of September, which is
also the birthday of the famous teacher, academic philosopher and
the second President of India, Mr. Sarvepalli Radhakrishan.
Dr. Sarvepalli Radhakrishnan was born in the year 1888 in a well-
known religious state in Chennai, then called Madras. He was the
second son of Veera Samayya, a tehsildar in a zamindari. It was a
middle-class, respectable Hindu Brahmin family.
He graduated with a Masters Degree in Arts from Madras
University. In partial fulfillment for his M.A. degree,
Radhakrishnan wrote a thesis on the ethics of the Vedanta titled
The Ethics of the Vedanta and Its Metaphysical Presuppositions,
which was a reply to the charge that the Vedanta system had no
room for ethics.
The Origin of Teachers Day: Since 1962, 5th of September has been
celebrated as Teachers Day in India. Dr. Sarvepalli
Radhakhrishnan was a philosopher and a teacher par excellence.
Some of his students and friends approached him and requested
him to allow them to celebrate his birthday. In reply, Dr,
Radhakrishnan said, Instead of celebrating my birthday
separately, it would be my proud privilege if September 5th is
observed as Teachers day. The request showed
Dr.Radhakrishnans love for the teaching profession. From then
onwards, his birthday is observed as Teachers Day in India.
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He showed how western philosophers, despite all claims to
objectivity, were biased by theological influences from their wider
culture. In one of his major works he also showed that Indian
philosophy, once translated into standard academic jargon, is
worthy of being called philosophy by western standards. His main
contribution to Indian thought, therefore, is that he placed it on
the map, thereby earning Indian philosophy a respect that it had
not had before.
Dr. Radhakrishnan was of the opinion that only the right kind of
education could solve many ills of the society and the country. He
wanted to bring in a change in the educational system by
improving the quality of education and building up a strong
relationship between the teacher and the taught. In his opinion,
teachers should be the best minds of the country; they should not
merely instruct but should gain the true affection of pupils, and the
respect for teachers cannot be ordered but it should be earned.
After 1946, his philosophical career was cut short when his
country needed him as ambassador to UNESCO and later to
Moscow. He was later to become the first Vice-President and
finally the President (1962-1967) of India. He was awarded the
Bharat Ratna in 1954. The University of Oxford instituted the
Radhakrishnan Chevening Scholarships and the Radhakrishnan
Memorial Award in his memory. He also received the Peace Prize
of the German Book Trade in 1961.
Even as the president Sarvepalli remained a humble man. It was an
open house at the Rashtrapati Bhavan and people from all sections
of society were welcome to meet him. In addition he accepted only
Rs. 2,500 out of his salary of Rs. 10,000 and donated the remaining
amount to the Prime Ministers National Relief Fund every month.
He remained a teacher in many ways and even adopted the
authoritative tone of a headmaster in many of his letters to his
ministers. Sarvepalli Radhakrishnan passed away on April 17, 1975.

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NEWS UPDATE
Use of dengue vaccine may cause short-term
spikes in its prevalence: (5
th
September, 2014)
As researchers continue to work toward vaccines for serious
tropical diseases such as dengue fever, experts caution in a new
report that such vaccines will probably cause temporary but
significant spikes in the disease in the years after they are first
used.
First international standards for growth of
developing babies, size of newborns: (5
th

September, 2014)
The first international standards for fetal growth and newborn size
have been developed by a global team led by scientists. Now, for
the first time, all 120 million babies born each year across the
world can be assessed using a common set of standards, reflecting
how babies should grow when mothers have adequate health,
nutrition, medical care and socioeconomic status.
One in five child deaths in England preventable,
as are many other types, study shows: (5
th

September, 2014)
A new series of articles highlights the substantial number of
preventable deaths in England. For example, 20% of child deaths
reviewed between 2010 and 2011 (800 of 4601) were from
preventable causes including accidents, suicide, abuse, and neglect.
Moreover, the series reveals that death rates vary widely between
and within high income countries and between different age
groups. At an international level, a higher proportion of deaths in
older children in the USA, Australia, and New Zealand are due to
external causes.
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New blood test could offer more tailored
treatment of ovarian cancer: (5
th
September,
2014)
A new blood test allowing doctors to predict which ovarian cancer
patients will respond to particular types of treatment is a step
closer following a new study. Researchers say the test could be
developed and used in hospitals within the next few years.
Caffeine therapy for apnea of prematurity does
not have long-term harmful effects on sleep:
(5
th
September, 2014)
Caffeine therapy for apnea of prematurity has no long-term
harmful effects on sleep or control of breathing, according to a new
study of 201 preterm children assessed at ages 5-12, the first study
in humans to examine the long-term effects of neonatal caffeine
treatment on sleep regulation and ventilatory control.
Novel microneedle patch for faster, effective
delivery of painkiller, collagen: (5
th
September,
2014)
A simple technique has been developed to encapsulate lidocaine, a
common painkiller, or collagen in the tiny needles attached to an
adhesive patch. When applied to the skin, the microneedles deliver
the drug or collagen rapidly into the skin without any discomfort
to the user.
Potassium-rich foods cut stroke, death risks
among older women: (4
th
September, 2014)
Older women who eat foods with higher amounts of potassium
may be at lower risk of stroke and death than women who
consume less potassium-rich foods. The health benefits from
potassium-rich foods are greater among older women who do not
have high blood pressure. Most older American women do not eat
the recommended amounts of potassium from foods.
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Rare stem cells hold potential for infertility
treatments: (4
th
September, 2014)
Rare stem cells in testis that produce a biomarker protein called
PAX7 help give rise to new sperm cells -- and may hold a key to
restoring fertility, research suggests. Infertility, which the Centers
for Disease Control estimates affects as many as 4.7 million men in
the United States, is a key complication of cancer treatments, such
as chemotherapy and radiation therapy.
Knowing how bacteria take out trash could lead
to new antibiotics: (4
th
September, 2014)
A team of scientists has reconstructed how bacteria tightly control
their growth and division, the cell cycle, by destroying specific
proteins through regulated protein degradation. All organisms use
controlled protein degradation to alter cell behavior in response to
changing environment. A process as reliable and stable as cell
division also has to be flexible, to allow the organism to grow and
respond. But little has been known about the molecular mechanics
of how this works.
Minimally invasive, high-performance intervention
for staging lung cancer: (4
th
September, 2014)
Endoscopic biopsy of lymph nodes between the two lungs
(mediastinum) is a sensitive and accurate technique that can
replace mediastinal surgery for staging lung cancer in patients
with potentially resectable tumors. The new study shows that it is
not necessary to perform surgery to confirm negative results
obtained through the endoscopic approach during the pre-
operative evaluation of patients with this type of cancer. This
discovery has many advantages for both the patients and the
health-care system.


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Important regulators of immune cell response
identified: (4
th
September, 2014)
A more effective method to determine how T cells differentiate
into specialized cell types has been identified by researchers. The
new approach could help accelerate laboratory research and the
development of potential therapeutics, including vaccines. The
method may also be used to identify the genes that underlie tumor
cell development.
Avian influenza virus isolated in harbor seals
poses a threat to humans: (4
th
September,
2014)
The avian influenza A H3N8 virus that killed harbor seals along
the New England coast can spread through respiratory droplets
and poses a threat to humans, scientists have found. The findings
reinforce the need for continued surveillance of flu viruses
circulating in wild and domestic animals to understand the risk
the viruses pose to humans, said the study's first author.

For detail mail to editor



KNOWLEDGE BASED ARTICLE
Edible vaccines
Plants offer enormous potential as production platform for
vaccines. Stable integration of a gene into the plant nuclear or
chloroplast genome can transform higher plants (tobacco, potato,
tomato, and banana) into bioreactors for the production of subunit
vaccines. From here, the existence of edible vaccines comes into
being. This plant derived vaccines present an alternative to
conventional vaccines by facilitating safe and effective oral delivery
through the consumption of edible plant tissue.
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05-09-2014

Owing to its low cost, it would suitable for developing countries
like India. Edible vaccines are mucosal targeted vaccines which
causes stimulation of both systemic and mucosal immune
response. Todays development of novel vaccines stresses the need
for edible vaccines that are inexpensive and easily administered.
The production of recombinant vaccines in plants may overcome
some of the major difficulties encountered while using traditional
or sub-unit vaccines. In developing countries, difficulties include
vaccine affordability, the need for cold chain from producer to
the site of use of the vaccine and also on dependence on injections
whereas plant derived vaccines do not face these issues. The offer
increased safety, envisaged low cost of programme for mass
vaccination and wider use of vaccination for veterinary use. Thus,
the use of plant vaccine may overcome some of the major diseases
like measles, cholera, hepatitis B, hey may also help to suppress
auto immune disorders like type I diabetes, diarrhoea, multiple
sclerosis and rheumatoid arthritis. They also offer a unique
opportunity and a convenient tool against the threat against
bioterrorism.
Advantages-
Potential advantages of plant based vaccines are-
Edible means of administration
Reduced need for medical personnel and sterile injection
conditions
Economical in mass production and transportation
Therapeutic proteins are free from pathogens and toxins
Storage near the site of use
Heat stable, eliminating the need for refrigeration.
Subunit vaccine(not attenuated pathogens) means improved safety
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05-09-2014

Generation of systemic and mucosal immunity
Delivery of multiple antigens
Ease of use as raw food or as dry powder
Plant species-
To date many plant species have been used for vaccine production.
Early studies use tobacco, potato but now tomato, banana, corn,
lupine, lettuce and others are being used for this purpose. The
choice of plant species (and tissue in which the protein
accumulates) is important and is usually determined how the
vaccine is to be determined in the future. For example an edible
palatable plant is necessary is the vaccine is planned for raw
Mechanism of action-
Most pathogens enter at the mucosal surface lining the digestive,
respiratory, and urino-reproductive tracts, which are collectively
the largest immunologically active in tissue in body.
The mucosal immune system(MIS) is the first line of defence and
the most effective site for vaccination against those pathogens,
nasal and oral vaccine being the most effective.
Peyers patches(PP) are an enriched source of IgA producing
plasma cells and have the potential to populate mucosal tissue and
serves as mucosal immune effector sites.
The breakdown of edible vaccines occur in PP, consisting of 30-40
lymphoid nodules on the outer surface of the intestine and contain
follicles from which germinal center develops upon antigenic
stimulation.
These follicles from which antigen penetrates the intestinal
epithelium, thereby accumulating antigen within organised
lymphoid structure. The antigen then comes in contact with M-
cells .
It contacts with the lumen with broad membrane process and
contains a deep invagination in the basolateral plasma membrane.
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05-09-2014

This pocket is filled with a cluster of B-cells, T-cells and
macrophages.
M-cells express class II MHC molecules and antigens
transported across the mucous membrane by M-cells can activate
B-cells within these lymphoid follicles.
The activated B-cells leave the lymphoid follicles and migrate to
diffuse mucosal associated lymphoid tissue(MALT) where they
differentiate into plasma cells that secrete the IgA calss of
antibodies.
These IgA antibodies are transported across the epithelial cells
into secretions of the lumen where they can interact with the
antigens present in the lumen.








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05-09-2014



Oral delivery, mucosal and systemic antibody responses:
Plant-derived vaccines have demonstrated the ability to induce
both systemic and mucosal immune responses.
The major obstacle to oral vaccination is the digestion of the
antigenic protein in the stomach.
Vaccines derived and delivered by plant cells have been shown to
overcome this problem through the protective effect of the plant
cell wall.
Like liposome and microcapsules, the plant cell wall allows
gradual release of the antigen onto the vast surface area of the
lower digestive tract.
Further problems may be associated with poor immunogenicity or
the induction of tolerance.
Binding to a targeting molecule or carrier peptide, such as HbsAg,
has been shown to overcome poor immunogenicity of orally
delivered subunit vaccines.

A unique opportunity against the threat of bio-weapons:

A number of infectious diseases, including smallpox, anthrax and
plague have recently raised concern for their possible use in
actions of bio-terrorism.
Nations at risk are now faced with the need to be ready to
vaccinate part or all of their population within limited periods of
time.
This means that millions of vaccine doses have to be prepared,
stored and renewed at intervals of time.
The economic and technical benefits offered by plant-derived
vaccines propose these vaccines as ideal substitutes for
traditional vaccines.
Research on plants that produce antigens against major pathogens
feared in case of bio-terrorism is already under way.
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05-09-2014



Dosage:
To explain the concept of oral therauptic protein delivery,
hepatitis B surface antigen(HBsAg) was used for oral
immunisation. No primary immune response was detected after
two 300microgram doses of yeast derived HBsAg. However a
primary response began after two servings of transgenic potatoes
containing, 85-300microgram of HBsAg.

Side effects:
A research by National Institute Of Allergy & Infectious Diseases
(NIAID), National Institutes of Health (NIH) and University of
Maryland School Of Medicine showed no significant side effects.
Limitations:
Development of immune tolerance to vaccine peptide or protein
Consistency of dosage form fruit to fruit, plant to plant , and from
generation to generation is not similar
Stability of vaccine in fruit is not known
Selection of best plant is difficult
Certain foods like potato are not eaten raw, and cooking the food
might weaken the medicine present in it.
Anurag Chanda
Student, GNIPST
B.Pharm, 4
th
Year


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05-09-2014

DISEASE RELATED BREAKING NEWS
Human infection with avian influenza A (H7N9)
virus: (4
th
September, 2014)
On 2 September 2014, the National Health and Family Planning
Commission of China notified WHO of 2 additional laboratory-
confirmed cases of human infection with avian influenza A(H7N9)
virus. Read more

UPCOMING EVENTS
5
th
International Conference on Stem Cells and Cancer 2014, JNU
Convention Centre, New Delhi, India from 8-10 November, 2014

DRUGS UPDATES
FDA Approves Keytruda (pembrolizumab) for
Advanced Melanoma: (4
th
September, 2014)
The U.S. Food and Drug Administration granted accelerated
approval to Keytruda (pembrolizumab) for treatment of patients
with advanced or unresectable melanoma who are no longer
responding to other drugs. Read more

CAMPUS NEWS
Today, on 5
th
September, 2014 the students of GNIPST have
arranged a wonderful Teachers Day Programme. On behalf of all
the teachers of GNIPST I would like to thank our beloved
students.
The Freshers welcome programme was held on 14
th
August, 2014.
Welcome 1
st
year students.
We congratulate the following M.Pharm. final year students who
have made their positions in different pharmaceutical companies.
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05-09-2014

Anirban Banerjee (Emami Ltd.)
Mahender Roy (Stadmed private Ltd.)
We congratulate the following B.Pharm. final year students for
their success.
Samadrita Mukherjee (Abbott India Ltd.)
Suman Sarkar (Tata Medical Centre-Apollo Pharmacy)
Shrewashee Mukherjee (Fresenius Kabi-Parenteral Nutrition)
Avishek Naskar (Glaxo SmithKline-Marketing)
Bappaditya Manik (USV Limited)
Sarbani Das (Nutri Synapzz-Marketing)
Ankita Roy (Nutri Synapzz-Marketing)
Rahul Mitra (B M Pharmaceuticals-Production)
The following B.Pharm. final year students have qualified, GPAT-
2014. We congratulate them all.
Utsha Sinha
Satarupa Bhattacharya
Sandipan Sarkar
Purbali Chakraborty
Reminiscence, 2014(GNIPST Reunion) was held in College
campus on 2
nd
February,2014.
1
st
Annual Sports of GNIPST was held on 3
rd
February,2014 in
College campus ground.
An industrial tour and biodiversity tour was conducted in Sikkim
for B.Pharm and B.Sc. students under the supervision of Mr. Asis
Bala, Ms. Jeentara Begum and Ms. Moumita Chowdhury.
B.Pharm 3
rd
year won the GNIPST Football Champions trophy,
2013. B.Pharm 3
rd
year won the final match 1-0 against B.Pharm 2
nd

year. Deep Chakraborty was the only scorer of the final.

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05-09-2014

STUDENTS SECTION
WHO CAN ANSWER FIRST????
Which day is celebrated as World
Teachers' Day?
From which year teachers' day is
celebrated in India?
Answer of Previous Issues Questions:
A) DRDO
B) Afghanistan
Identify the person


Answer of Previous Issues Image:
Richard Martin Willsttter
Send your thoughts/
Quiz/Puzzles/games/write-ups or any other
contributions for Students Section&
answers of this Section at gnipstbulletin@gmail.com



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05-09-2014

EDITORS NOTE
It is a great pleasure for me to publish the 2
nd
issue of 37
th
Volume
of GNIPST BULLETIN. All the followers of GNIPST BULLETIN
are able to avail the bulletin through facebook account GNIPST
bulletin I am very much thankful to all the GNIPST members and
readers who are giving their valuable comments, encouragements
and supports. I am also thankful to Dr. Abhijit Sengupta, Director
of GNIPST for his valuable advice and encouragement. Special
thanks to Dr. Prerona Saha, Mr. Debabrata Ghosh Dastidar
and Mr. Soumya Bhattacharya for their kind co-operation and
technical supports. Thank you Mr. Soumya Bhattacharya for the
questionnaires of the student section. An important part of the
improvement of the bulletin is the contribution of the readers. You
are invited to send in your write ups, notes, critiques or any kind of
contribution for the forthcoming special and regular issue.

ARCHIVE
Students of GNIPST organized pre puja celebration programme,
Saaranya on 7
th
October, 2013 in college Auditorium.
GNIPST organized a garment distribution programme on 28
th

September, 2013 at Dakshineswar Kali Temple and Adyapith,
Kolkata. On this remarkable event about hundred people have
received garments. More than hundred students and most of the
faculties participated on that day with lot of enthusiasm.
GNIPST celebrated World Heart Day (29
th
September) and
Pharmacists Day (25
th
September) on 25
th
and 26
th
September,
2013 in GNIPST Auditorium. A seminar on Violence against
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05-09-2014

woman and female foeticide was held on GNIPST Auditorium on
25
th
September organized by JABALA Action Research
Organization. On 26
th
September an intra-college Oral and Poster
presentation competition related to World Pharmacists day and
Heart day was held in GNIPST. Ms. Purbali Chakraborty of
B.Pharm 4
th
year won the first prize in Oral Presentation. The
winner of Poster presentation was the group of Ms. Utsa Sinha,
Mr. Koushik Saha and Mr. Niladri Banerjee (B.Pharm 4
th
year).
A good number of students have participated in both the
competition with their valuable views.
Teachers day was celebrated on 5
th
September, 2013 by the
students of GNIPST in GNIPST Auditorium.
Azalea (exotic flower ) , the fresher welcome programme for
newcomers of GNIPST in the session 2013-14 was held on 8
th

August in GNIPST Auditorium.
One day seminar cum teachers development programme for
school teachers on the theme of Recent Trends of Life Sciences
in Higher Education organized by GNIPST held on 29
th
June,
2013 at GNIPST auditorium. The programme was inaugurated by
Prof . Asit Guha, Director of JIS Group, Mr. U.S. Mukherjee, Dy
Director of JIS Group and Dr. Abhijit Sengupta, Director cum
Principal of GNIPST with lamp lighting. The programme started
with an opening song performed by the B.Pharm students of this
institute. The seminar consists of a series of lectures, video
presentations and poster session. On the pre lunch session 4
lectures were given by Dr. Lopamudra Dutta, Mr. Debabrata
Ghosh Dastidar, Ms. Swati Nandy and Ms. Tamalika Chakraborty
respectively. On their presentation the speakers enlighten the
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05-09-2014
recent development of Pharmacy, Genetics and Microbiology and
their correlation with Life Sciences. On the post lunch session,
Ms. Saini Setua and Ms. Sanchari Bhattacharjee explained the
recent development and career opportunities in Biotechnology
and Hospital Management. The programme was concluded with
valedictory session and certificate distribution.
About 50 Higher secondary school teachers from different
schools of Kolkata and North& South 24 Parganas district of
West Bengal participated in this programme. A good interactive
session between participants and speakers was observed in the
seminar. The seminar was a great success with the effort of
faculties, staffs and students of our Institute. It was a unique
discussion platform for school teachers and professional of the
emerging and newer branches of Life Science.
The general body meeting of APTI, Bengal Branch has been
conducted at GNIPST on 15
th
June, 2012. The program started
with a nice presentation by Dr. Pulok Kr. Mukherjee, School of
Natural Products, JU on the skill to write a good manuscript for
publication in impact journals. It was followed by nearly two hour
long discussion among more than thirty participants on different
aspects of pharmacy education. Five nonmember participants
applied for membership on that very day.
GNIPST is now approved by AICTE and affiliated to WBUT for
conducting the two years post graduate course (M.Pharm)
in PHARMACOLOGY. The approved number of seat is 18.
The number of seats in B.Pharm. has been increased from 60 to
120.
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05-09-2014
AICTE has sanctioned a release of grant under Research
Promotion Scheme (RPS) during the financial year 2012-13to
GNIPST as per the details below:
a. Beneficiary Institution: Guru Nanak Institution of Pharmaceutical
Science & Technology.
b. Principal Investigator: Dr. LopamudraDutta.
c. Grant-in-aid sanctioned:Rs. 16,25000/- only
d. Approved duration: 3 years
e. Title of the project: Screening and identification of potential
medicinal plant of Purulia & Bankura districts of West Bengal
with respect to diseases such as diabetes, rheumatism, Jaundice,
hypertension and developing biotechnological tools for enhancing
bioactive molecules in these plants.
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