Nama : Winna Marantika Saputri

Nim : 26141345C
Progdi : D III Anafarma
Fakultas : Farmasi
Kelompok : 3

Alkaloids Isolated from Natural Herbs as the Anticancer Agents
Jin-Jian Lu, Jiao-Lin Bao, Xiu-Ping Chen, Min Huang, and Yi-Tao Wang
State Key Laboratory of Quality Research in Chinese Medicine (University of Macau) and
Institute of Chinese Medical Sciences, University of Macau, Avenue Padre Tomas Pereira,
Taipa 999078, Macao, China
Received 11 May 2012; Revised 17 July 2012; Accepted 30 July 2012
Academic Editor: Alvin J. Beitz

Abstract
Alkaloids are important chemical compounds that serve as a rich reservoir for drug discovery.
Several alkaloids isolated from natural herbs exhibit antiproliferation and antimetastasis
effects on various types of cancers bothin vitro and in vivo. Alkaloids, such as camptothecin
and vinblastine, have already been successfully developed into anticancer drugs. This paper
focuses on the naturally derived alkaloids with prospective anticancer properties, such as
berberine, evodiamine, matrine, piperine, sanguinarine, and tetrandrine, and summarizes the
mechanisms of action of these compounds. Based on the information in the literature that is
summarized in this paper, the use of alkaloids as anticancer agents is very promising, but
more research and clinical trials are necessary before final recommendations on specific
alkaloids can be made.

Nama : Winna Marantika Saputri
Nim : 26141345C
Progdi : D III Anafarma
Fakultas : Farmasi
Kelompok : 3

Alkaloid Terisolasi dari Herbal Alami sebagai Agen Anti Kanker
Jin- Jian Lu, Jiao - Lin Bao, Xiu - Ping Chen, Huang Min, dan Yi - Tao Wang
Negara Laboratorium Kualitas Penelitian Kunci Pengobatan di Cina (University of Macau)
dan Institute of Chinese Medical Sciences, University of Macau, Avenue Padre Toma
Pereira, Taipa 999.078, Makau, Cina

Diterima 11 Mei 2012 ; Revisi 17 Juli 2012 ; Diterima 30 Juli 2012

Abstrak
Alkaloid adalah senyawa kimia penting yang berfungsi sebagai reservoir kaya untuk
penemuan obat. Beberapa alkaloid diisolasi dari tumbuh-tumbuhan alami antiproliferasi
pameran dan antimetastasis efek pada berbagai jenis kanker secara in vitro dan in vivo.
Alkaloid, seperti camptothecin dan vinblastine, telah berhasil dikembangkan menjadi obat
antikanker. Makalah ini berfokus pada alkaloid alami berasal dengan sifat antikanker calon,
seperti berberin, Evodiamine, matrine, piperine, sanguinarine, dan tetrandrine, dan
merangkum mekanisme kerja senyawa ini . Berdasarkan informasi dalam literatur yang
diringkas dalam makalah ini, penggunaan alkaloid sebagai agen antikanker yang sangat
menjanjikan, namun penelitian lebih lanjut dan uji klinis yang diperlukan sebelum
rekomendasi akhir pada alkaloid tertentu dapat dibuat .