Monodisperse Enacpasulates Process Technologies

Detailed Description & Requirements

Need Description:
We are looking for proven process technologies that can produce:
1. In general, highly monodisperse spherical particles
2. Specifically, highly monodisperse spherical particles that are of the type: core-shell
microcapsules having high loading efficiency, a range of release triggers and be compatible
with a wide range of payloads.
The highly monodisperse spherical particles or microcapsules may be found in a size range
from 250 nm to 50 microns.

Background:
Perfume microcapsules have a high loading efficiency for perfume oils of relatively low polarity,
and can release these fragrance payloads upon mechanical rupture of the capsules shells.
However, it is difficult to incorporate more polar payloads, or tailor the release of the payload
with conventional processes. Microfluidic processes are known and can overcome some of
these limitations, but scale up of these remains to be proven for the large volumes required for
consumer packaged goods.

We are looking for:
Production processes for encapsulating a wide range of active ingredients, with tight control of
particle sizes (approaching monodispersity) selectable over a wide range of particle sizes from
less than about 1 micron (but > 250 nm) up to about 50 microns.
Production processes should meet the following requirements:
Capable of producing spherical microcapsules with a unimodal Particle Size Distribution of
about 1.2 (e.g., DV90 and DV10 are within 20% of DV50).
Capable of producing >10 T/yr (dry weight) of encapsulate (need not be fully reduced to practice
at this scale, but at least pilot scale) with minimum loading efficiency 30%, preferably >50% or
as high as >75%. Slurry or dry powder is acceptable.
Though we will consider some development if needed, a well-developed technology and/or
currently in-market technology is ideal.

We are not looking for:
Micro molding processes (e.g., PRINT from Liquidia)
Templating / calcining or extracting approaches
Academic/bench scale approaches that have not been taken at least to early phases of
commercialization (rates/scales).
Please note that only non-confidential information can be accepted for review.
If you have existing or new production processes for encapsulating a wide range of active
ingredients, with tight control of particle sizes that you think fit with our needs, please submit
them immediately for review, submissions will be forwarded for review shortly after they are
received.

Project Criteria
This is an electronic Request-for-Partners (eRFP) Challenge; the Solver will only need to submit
a written proposal to be evaluated by Procter & Gamble with a goal of establishing a
collaborative partnership.
The submitted proposals should include two parts:
1. Capabilities Description including:
a. A description of the existing or new production processes against the above listed
requirements. The Solvers are expected to provide non-confidential information. The
Solvers should provide enough information for Procter & Gamble to appreciate the merits of
their production processes;
b. A brief discussion of prior experience as related to the solution including relevant example,
if available, in this domain;
c. A brief overview of a project (deliverables, timelines, milestones, and cost estimates).
2. General Information about the Solver including:
a. Organization/Company name and address (including website, if available);
b. The key contact person for this Challenge (including phone number and email address).
(Note: For most Challenges, Solvers are not allowed to include personal contact
information; however, for an eRFP Challenge, it is required.)

How eRFP Challenges work:
In contrast with other types of Challenges, there is no a predetermined Award for eRFP
Challenge. The potential award would be a contract with Procter & Gamble to conduct
collaborative work and/or to provide materials and services to Procter & Gamble in the future.
After the deadline and all proposals have been forwarded to Procter & Gamble for evaluation, if
Procter & Gamble identifies the Solver as a potential partner, they will contact the Solver directly
to discuss the potential partnership and terms of any contract. Neither party is obligated to work
together until a mutually agreeable contract is agreed upon.