Anda di halaman 1dari 2

Trial design Results

Multicenter, randomized, 28-week,


double-blind, placebo-controlled, dose-
ranging (600, 1200, and 2400 mg/da!, 4-
arm, parallel-group trial ("arcs et al
2000!#

$%carbazepine ad&uncti'e t(erap was
)ound to be a sa)e and e))ecti'e t(erap in
patients wit( uncontrolled partial seizures#
*))ecti'eness increased wit( dose#
Multicenter, double-blind, randomized,
parallel-group trial to assess t(e
antiepileptic e))icac o) o%carbazepine as
monot(erap in a re)ractor epileps
patient population ("edoun et al 2000!#

$%carbazepine was )ound to be sa)e and
e))ecti'e in t(e treatment o) patients wit(
partial epileps pre'iousl recei'ing
treatment wit( ot(er antiepileptic drugs#
Multicenter, randomized, placebo-
controlled trial o) o%carbazepine as
ad&uncti'e t(erap in c(ildren wit(
inade+uatel controlled partial seizures
on 1 or 2 concomitant antiepileptic drugs
(,lauser et al 2000!#

$%carbazepine ad&uncti'e t(erap was
)ound to be sa)e, e))ecti'e, and well
tolerated in c(ildren wit( partial seizures#
Multicenter, double-blind, randomized,
placebo-controlled, 2-arm parallel group,
monot(erap design (-c(ac(ter et al
1...!#

$%carbazepine monot(erap was e))ecti'e
and sa)e#
/ouble-blind, controlled clinical trial o)
o%carbazepine 'ersus p(entoin as
monot(erap in c(ildren and adolescents
wit( epileps (,uerreiro et al 1..0!#

$%carbazepine s(owed e))icac and sa)et
as )irst-line treatment and (ad signi)icant
ad'antages o'er p(entoin in terms o)
tolerabilit#
/ouble-blind, randomized, parallel-group
comparison wit( p(entoin in adult
patients wit( epileps ("ill et al 1..0!#
1(ese trials support t(e e))icac and sa)et
o) o%carbazepine as )irst-line treatment# 2n
addition, t(e results s(ow t(at
o%carbazepine (as signi)icant ad'antages
o'er p(entoin in terms o) tolerabilit#

/ouble-blind, randomized, parallel-group
comparison wit( sodium 'alproate in
adult patients wit( epileps (3(riste et al
1..0!#

*))icac and tolerabilit o) o%carbazepine
was e+ui'alent to t(at o) 'alproic acid#
/ouble-blind, randomized, parallel-
group, monot(erap trial compared
o%carbazepine at 2400 mg/da wit(
o%carbazepine at 400 mg/da in patients
wit( uncontrolled partial-onset seizures
(-ac(deo et al 2001!#

$%carbazepine monot(erap at 2400
mg/da is well tolerated and e))icacious in
patients wit( uncontrolled partial onset
seizures#
5rospecti'e, open-label, multicenter
stud to e'aluate t(e e))icac and
$%carbazepine as monot(erap ma be a
)a'orable treatment option )or patients wit(
tolerabilit o) o%carbazepine as
monot(erap in patients wit( partial
seizures w(o switc(ed )rom t(eir current
antiepileptic drug monot(erap because
o) lack o) e))icac or poor tolerabilit
(Martinez et al 2006!#
partial seizures or t(ose w(o s(ow poor
tolerabilit o) t(eir e%isting monot(erap
regimen#