1

CHEMISTRY
INVESTIGATORY
PROJECT
TOPIC :- To determine the amount of
asprin!acetyl salicylic acid" present in the the
asprin tablet
SUBMITTED BY:- Shobiitaa Krishna


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"#$%&'()*+),)%-
lL glves me lmmense pleasure Lo express my deep sense of
graLlLude Lowards my emlnenL chemlsLry Leacher Mr.
8|[eesh k1k who has always been Lhere as guldlng splrlL
behlnd Lhe successful compleLlon of Lhe pro[ecL.

l am also graLeful Lo our Lab AsslsLanL Mrs.Iunnet for her
valuable guldance and encouragemenL LhroughouL Lhe
course and preparaLlon of Lhls pro[ecL.



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INDLk
S.No. 1CIC AGL
1.) AIM 4
2.) IN1kCDUC1ICN S
3.) INDUS1kIAL SN1nLSIS 6
4.) 1I1kA1ICN 8
S.) kLUIkLMLN1S 9
6.) kCCLDUkL 10
7.) C8SLkVA1ICNS 11
8.) CCNCLUSICN 12
9.) 8I8LICGkAn



4







".,

ln 1PlS LxL8lMLn1 Cu8 AlM lS 1C 8un A 1l18A1lCn 1C uL1L8MlnL
1PL AMCun1 Cl ASl8ln (ACL1?L SALlC?LlC AClu) 8LSLn1 ln An
ASl8ln 1A8LL1.







3

.%-/&*0#-.&%

Asplrln ls a sallcylaLe drug, ofLen used as analgeslc Lo
relleve mlnor aches and palns, as an anLlpyreLlc Lo
reduce fever, and as an anLl-
lnflammaLory medlcaLlon. SusLalned 8elease dosage
form also acLs as a blood Lhlnner and ls lndlcaLed ln
cardlac paLlenLs.
1he asplrln wlll be LlLraLed agalnsL a sLandard soluLlon
of base, 0.100 M naCP. 8ase wlll be dlspensed from
a bureLLe lnLo a beaker conLalnlng Lhe dlssolved (ln
eLhanol) acld and phenolphLhaleln lndlcaLor, whlch
wlll show a falnL plnk color ln baslc soluLlons. ln
addlLlon Lo conLalnlng aceLylsallcyllc acld, any asplrln
LableL also conLalns pharmaceuLlcal alds llke blndlng
agenL, dlslnLegraLlng agenL, pollshlng agenL and oLher
exclplenLs as requlred.


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"#$%&'( )*#+
Asplrln ls used Lo reduce fever and relleve mlld Lo moderaLe
paln from condlLlons such as muscle
aches, LooLhaches, common cold, and headaches. lL may
also be used Lo reduce paln and swelllng ln condlLlons such
as arLhrlLls. Asplrln ls known as a sallcylaLe and a
nonsLeroldal anLl-lnflammaLory drug (nSAlu). lL works by
blocklng a cerLaln naLural subsLance ln your body Lo reduce
paln and swelllng.

'*,%-%. */.01#*%* '0 %.$)*0-%'( (#2#(+
SynLhesls of asplrln ln lndusLry ls done ln Lwo sLeps.
1he flrsL sLep ln Lhe lndusLrlal synLhesls of asplrln ls
Lhe ko|be-Schm|tt carboxy|at|on react|on, ln whlch sodlum
phenoxlde adds Lo carbon dloxlde gas under pressure. 1hls
reacLlon ylelds an lnLermedlaLe keLo acld anlon, whlch
enollzes Lo produce sallcyllc acld.

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1he nexL sLep of Lhe synLhesls ls Lhe aceLylaLlon of sallcyllc
acld wlLh aceLlc anhydrlde, whlch occurs vla a nucleophlllc
acyl subsLlLuLlon mechanlsm.



1hls produces aceLylsallcyllc acld (M
r
= 180.2 gmol
-1
), a whlLe
crysLalllne powder whlch ls sllghLly soluble ln waLer. 1he
LemperaLure ls malnLalned aL 70-80
o
C.
Cnce Lhe asplrln ls prepared lL musL be lsolaLed from Lhe
reacLlon soluLlon and purlfled. 1he asplrln ls lnsoluble ln
cold waLer, and can be lsolaLed by fllLerlng Lhe chllled
reacLlon soluLlon. urlflcaLlon ls necessary Lo remove any

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unreacLed sallcyllc acld and aceLlc anhydrlde, as well as Lhe
aceLlc acld producL and phosphorlc acld. AceLlc anhydrlde
ls caused Lo decompose by Lhe addlLlon of waLer once Lhe
formaLlon of asplrln ls compleLe:

1he aceLlc acld and phosphorlc acld are waLer soluble and
can be removed by washlng Lhe asplrln wlLh chllled waLer.
Sallcyllc acld ls only sllghLly soluble ln waLer and ls noL
compleLely removed ln Lhe washlng sLep.
llnal purlflcaLlon ls accompllshed by Lhe process
of recrysta|||zat|on. 1he lmpure asplrln ls dlssolved ln
warm eLhanol. 1he soluLlon ls Lhen cooled slowly, and Lhe
asplrln crysLalllzes ouL of soluLlon leavlng Lhe sallcyllc acld
and oLher lmpurlLles behlnd.








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-.-/"-.&%


Asplrln ls an acld. 1he acLlve lngredlenL ls aceLyl sallcyllc
acld. ulfferenL sLrengLhs of asplrln are based on Lhe
amounL of acLlve lngredlenLs LhaL Lhey conLaln. 1lLraLlon ls
a way Lo deLermlne how much acld ls ln a soluLlon by
addlng [usL enough base of a known concenLraLlon Lo
neuLrallze Lhe acld. ln neuLrallzaLlon, Lhe numbers of moles
of acld, P
+
, are comblned wlLh an equal number of moles
of base, CP
-
. ln Lhe LlLraLlon we wlll be performlng, we wlll
dlspense base lnLo a known amounL of acld soluLlon Lo flnd
Lhe unknown concenLraLlon. lf we wanLed Lo know Lhe
concenLraLlon of an unknown base, we could LlLraLe Lhe
base wlLh an acld ln Lhe same manner.



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#1),.2-/3 &4 -1) -)2-5
1he followlng reacLlon occurs.








11
/)60./),)%-2
#789:;<=> <?@ ,<A8B:<=>5
1. 0.100 M naCP
2. LLhyl alcohol
3. Asplrln
4. henolphLhaleln lndlcaLor
"CC<B<AD>5
1. 8ureLLe
2. MorLar and pesLle
3. 130 mL flask
4. lpeLLe


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E/&#)*0/)

1. llnd Lhe mass of an asplrln LableL. Crlnd each LableL lnLo
a flne powder by uslng a morLar and pesLle.
2. 1are a plece of welghlng paper on Lhe balance. Carefully
Lransfer as much powdered sample Lo a plece of paper and
Lhen deLermlne Lhe mass.
3. lace Lhe powdered sample ln a 130mL beaker.
4. Add a 10.0 mL porLlon of eLhyl alcohol Lo Lhe beaker and
sLlr.
3. Add 23.0mL of waLer Lo Lhe beaker.
6. uL 3 drops of Lhe phenolphLhaleln lndlcaLor ln your
flask.
7. 1he bureLLe ls fllled wlLh 0.100M naCP. Make sure
Lhere are no bubbles apparenL ln Lhe bureLLe. 8ecord Lhe
lnlLlal volume on Lhe bureLLe.
8. 8egln LlLraLlng, Add Lhe naCP ln 1.0mL lncremenLs,
maklng noLe of when Lhe color change occurs. ConLlnue
addlng base 3.0 mL pasL Lhe equlvalence polnL (Lhe

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equlvalence ls approxlmaLely when Lhe soluLlon Lurned
plnk from Lhe phenolphLhaleln).
9. 8epeaL sLeps 1-8 for Lhe remalnlng LableLs.














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&F2)/G"-.&%2
volume of Asplrln used
(mL)(v
1
)
volume of naCP used
(mL)(v
2
)
33 11.4
33 11.3
33 11.3
ConcordanL 8eadlng: 11.3 mL

M
Asplrln
=?
M
naCP
=0.1 M
v
Asplrln
=33 mL
v
naCP
=11.3mL
M
Asplrln
v
Asplrln
= M
naCP
v
naCP

M
Asplrln
33=0.111.3
M
Asplrln
=0.0328 M
m
Asplrln
=207 mg/ LableL



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#&%#(02.&%
Accordlng Lo Lhe experlmenL, Lhe amounL of asplrln
presenL ln each LableL of ulsprln ls 207 mg. 1he real
amounL may be of equal value lf Lhere weren'L any mlnor
experlmenLal errors whlch lnclude :
use of LaboraLory reagenLs whlch are noL as accuraLe
as quallLy conLrol reagenLs acLually used for
conducLlng CA sLudles.
1he exclplenLs add Lo Lhe bulk of Lhe LableL along wlLh
asplrln whlch may also lnLerfere wlLh Lhe resulLs.




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F.F(.&+/"E13
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