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Vince Philip: Dr. Moerck tell us about Valensas positon in the Astaxanthin market.

Dr. Moerck: Valensa started of as a supercritcal CO2 fuid extracton (SCFX) facility
specializing in US Plus Saw Palmeto. In 2002 Valensa acquired La Haye
Laboratories along with rights to the Tso eye healthcare patent (US
Patent No. 5,527,533) La Haye had been producing Astaxanthin
since 1986. Valensa subsequently perfected the extracton and
stabilizaton of Astaxanthin. Valensa was the frst company to obtain
European Novel Foods approval for their Zanthin brand Astaxanthin.
Vince Philip: What is diferent about Zanthin brand Astaxanthin compared to your
compettors?
Dr. Moerck: Valensas Astaxanthin is extremely stable due to the O2B package that
we add to our astaxanthin products. We guarantee 4 years shelf
life based on 7 years of excellent stability data on our product. Our
product is also produced in an allergen free facility that is Organic
Certfed. Valensa is the only Astaxanthin producer that actually
extracts Astaxanthin from algae biomass. Valensa is also the only
producer of Astaxanthin in the United States. All other compettors
have their extracton done by third party of-shore contractors, some
of which also extract products such as green lipped mussels (shell fsh)
which contain serious allergens. Valensa does not use Safower oil,
as a dilutng agent, as one of our compettors does, because it
introduces shelf life instability into the formulaton. Valensa only uses
extra virgin olive oil to standardize our Zanthin product.
Vince Philip: Recently Astaxanthin was featured on the Dr. Oz television show and
was discussed by Dr. Mercola, founder of www.mercola.com . On
that show, daily doses of up to 10 mg per day were discussed. Is this
a reasonable dose or is this excessive?
Dr. Moerck: I am very grateful to Dr. Mercola and Dr. Oz for drawing atenton to
Astaxanthin supplementaton for improving human health. You will
fnd several videos on YouTube with Dr. Mercola and Dr. Moerck that
Valensa Internatonal
2751 Nutra Lane
Eusts, Florida 32726
(352) 357-2004
www.valensa.com
Astaxanthin
Use, Pharmacokinetics and Dosing
An Interview with Dr. Rudi E. Moerck,
President of Valensa International
Dr. Rudi E. Moerck joined
Valensa in 2005 and led
the management team
in implementng a new
corporate strategy focused
on turning the Company into
a science-based developer
of botanically sourced
products for human health
and well-being.
Rudi holds a BS degree
in Biology from Florida
Southern College and a
Ph.D. from the University of
Florida in Organic Chemistry.
He was a NIH postdoctoral
fellow at Ohio State and
taught chemistry at Ohio
State and Ohio Wesleyan
University.
Valensa Internatonal
2751 Nutra Lane
Eusts, Florida 32726
(352) 357-2004
www.valensa.com
discusses the health benefts of Krill oil and Astaxanthin (small
amounts of Astaxanthin are naturally contained in Krill).
Based on published pharmacokinetc data conducted in humans, a 10 mg
dose of Astaxanthin is unnecessary and somewhat excessive. We do
not recommend a steady intake of 10 or more mg Astaxanthin per day
under any circumstances because this is really excessive, expensive
and wasteful. Because Astaxanthin is a fat soluble carotenoid and a
10 mg per day dose is 2.5 tmes the recommended dose, cosmetc
pigmentaton of the faty epithelial skin layer would be
expected with prolonged high dose consumpton much like
that observed in beta-carotenosis. Valensa recommends a maximum
dose of just 4 mg per day - for people that are under heavy oxidatve
stress such as athletes, or those that are exposed to excessive sunlight
or have occupatons where they are exposed to high levels of
ionizing radiaton (pilots), free radicals or singlet oxygen. A
single dose of 4 mg Astaxanthin per day is an excellent intake of this
potent fat soluble antoxidant. If you eat an 8 oz. porton of wild caught
salmon you consume about 3 mg of Astaxanthin that day. Afer
ingeston, plasma-bound Astaxanthin can stll be quantfed 100 hours
later. Since most people consume 2-4 mg Astaxanthin per day,
this dose will maintain a physiologically efectve level of Astaxanthin
in the body, especially in membranes of joints, eye, brain and muscle.
Astaxanthin is a fat or lipid soluble ant-oxidant with a published half-
life (T ) of 16 hours. That means that of the ingested and absorbed
Astaxanthin is stll present in plasma afer 16 hours in humans! It is
really quite simple. If the T is 16 hours and you take your Astaxanthin
every 24 hours, you will always have good tssue and
plasma levels of this king of carotenoids. In this regard,
Astaxanthin is really quite afordable and cost efectve. There would be
bioaccumulaton in faty tssue in the body of humans, just
like in salmon, at elevated doses. The protectve efect against oxidaton
displayed by all carotenoids, especially Astaxanthin, provides an
efectve shield against lipid oxidaton of faty acids in connectve
tssue and the skin.
Vince Philip: Are larger doses of Astaxanthin safe?
Dr. Moerck: One of the issues in the
Nutraceutcals industry is
that we must get away from
the more is beter
syndrome more is, in many
cases, not beter and in the
fnal analysis high dose
recommendatons do not
improve health and are
wasteful and unnecessarily more
Haematococcus pluvialis
cells afer stress
expensive to consumers. Our experience with Astaxanthin is that the
magic dose is 2 to 4 mg per day and not more, since most
people previously had only minor exposure to Astaxanthin
in their diets (salmon, shrimp). The excellent published bioavailability
and pharmacokinetcs of Astaxanthin (European Journal of
Pharmaceutcal Sciences 19 (2003) 299-304) shows that it is very
safe with a LD
50
of 600 mg/kg (rats, Valensa does not do animal testng)
and the conservatve No Adverse Efect Level (NOAEL) was calculated
to be 465 mg/kg (an average adult human weighs 60 kg), therefore
the LD
50
and the NOAEL taken together indicate that Astaxanthin is
remarkably safe, however, just because high doses are safe, does not
in any way make it a good idea to take more than 4 mg per day for
humans.
Why would somebody use Astaxanthin with 5 to 30 tmes the
ant-oxidant and free radical scavenging ability compared to Lutein want
to take a dose that is equal to the recommended dose levels of lutein (5-
10 mg/day)?
Vince Philip: Are there any side efects of excessive doses of
Astaxanthin besides being a waste of money?
Dr. Moerck: All carotenoids are fat soluble and accumulate in faty
tssue membranes including the skin. Excessive consumpton of Lutein,
beta-carotene and Astaxanthin, while safe, will actually lead to skin
discoloraton including yellow to yellow-orange to orange pigmentaton
of the skin (fair skinned people). I have seen this with excessive
Lutein ingeston of about 80 mg/day and the person actually turned
yellow. Initally I wrongly thought they had a liver disease, but I
determined the root cause as being excessive Lutein consumpton.
There are many documented medical cases of Beta-Carotenosis from
excessive intake of beta-carotene, another fat soluble carotenoid.
There is anecdotal evidence that visible skin pigmentaton can take
place when more than 20 mg Astaxanthin is taken per day. This is why
Valensa strongly discourages single doses of 10 mg Astaxanthin or
more. It is counter indicated because many people will take two doses
per day thinking that more is beter.
Carotenoid skin pigmentaton is probably not dangerous, but it is
unsightly, fully avoidable and of putng, in my opinion. It should be
noted that a single dose of 10 to 20 mg of Astaxanthin will not turn
you orange, but you will turn yellow or orange over a span of a few
weeks if these unreasonable doses are contnuously ingested.
Vince Philip: Why take Astaxanthin?
Dr. Moerck: Astaxanthin crosses the blood brain and blood eye barrier. It is a
An overview of Astaxanthin,
the King of Carotenoids.
View
Valensas
Astaxanthin
Videos
A tour of Valensas facility
with Dr. Rudi Moerck
Dr. Rudi Moercks
informatve interview with
Dr. Michael Lange
Valensa Internatonal
2751 Nutra Lane
Eusts, Florida 32726
(352) 357-2004
www.valensa.com
potent antoxidant and protects lipids contained in membranes
and in blood plasma against oxidatve damage. About 30% of the
brains and the eyes dry mass consists of DHA, and it is unequivocal
that Astaxanthin protects this membrane component for damage
caused by oxidaton. It has also been shown that Astaxanthin prevents
damage to DNA at a dose of just 2 mg per day in man. Protectng
membranes from oxidatve damage is good for cardiovascular health
because atherosclerosis is caused by lipid peroxidaton which leads to
inital vascular scar formaton.
Because of its outstanding antoxidant propertes, we recommend
Astaxanthin for eye, joint, brain and cardiovascular health.
Vince Philip: How should we take our 2 to 4 mg of Astaxanthin per day?
Dr. Moerck: It is always best to take Astaxanthin with faty food, or in combinaton
with a supplement that is also faty such as fsh oil or krill
oil. The product is commonly available in 4 mg sofgels. Faty
foods include sof boiled egg yolks, meat, buter, whole milk, nuts and
chocolate. The fat helps you absorb Astaxanthin fully. For vegetarians
or vegans, take Astaxanthin Omega-3 rich seed oils such as Chia or fax
seed, Chia or fax seed oil (refrigerated), Nutella, chocolate or nuts
such as almonds or walnuts.
Since krill oil produced today has very litle Astaxanthin in it (except for
Astamega-3 from PatentHEALTH), I always recommend taking a 2 to
4 mg dose of Astaxanthin with krill oil. The phospholipids found in
Krill oil help your body absorb Astaxanthin.
Vince Philip: Thank you very much, Dr. Moerck
One 4 mg dose of
Valensas Zanthin Natural
Astaxanthin Complex per day
is more than sufcient.