Summary &

Conclusion
Summary and Conclusion :
The aim of this investigation was to design Orodispersible dosage form of Tramadol
HCl. Due to bitter taste of the drug it cannot be easily administered. The taste masked
Orodispersible dosage form of Tramadol HCl may overcome the drawbacks associated with
conventional tablet such as bitter taste and requirement of water for swallowing.
Weak cation echange resins having a common polyacrylate backbone were used for
taste masking of Tramadol HCl. Cation echange resins !ndion "#$ was used. %atch process
was used for drug loading. The different resins ratio was used for formation of drug& resin
comple in the proportion of '&'( '&"( '&#. The resin !ndion "#$ masked the bitter taste of the
drug very effectively and showed maimum drug loading efficiency with drug& resin ratio
'&# so it was used for further studies.
The drug content in )resinate* drug& !ndion "#$ )'&#* was found to be ++.$$ ,. Taste
evaluation results showed the successful masking of bitter taste of drug with no after taste.
!nitially the drug and ecipients were characteri-ed then the powder blend of all the
formulation were prepared and evaluated for powder properties such as angle of repose( bulk
density( tapped density( , compressibility( and flowability. !t was found that all formulations
had good flowability indicate its suitability for direct compression.
Then using this blend the tablets was prepared by direct compression technique using
rotary tablet machine. .repared tablets then evaluated for weight variation( hardness(
friability( wetting time( water absorption ratio( !n/vitro disintegration time and( !n/vitro
dissolution rate. Hardness of all prepared tablets was found between #/$ kg0cm
"
( and friability
below ', showing that all tablets having good mechanical strength. The results of friability
indicated that the tablets were mechanically stable and could handle rigors of transportation
and handling. The water absorption ratio of tablet containing superdisintegrant was found to
be more than control tablets. Water absorption ratio of tablets containing cross carmellose
sodium as superdisintegrant was found more as compare to sodium starch glycolate and
!ndion $'$. Disintegration time of all the tablets was found within acceptable limit.
1ormulation containing cross carmellose sodium as superdisintegrant has less disintegrating
time compare to 223 and !ndion $'$.
[Formulation development and evaluation of Oro-dispersible tablet by direct
compression Method] Page !
Summary &
Conclusion
!n the study of !ndion $'$ was evaluated for its superdisintegrants action in
orodispersible tablets. The results for water absorption ratio( disintegration time( and
dissolution study showed it as acceptable superdisintegrats in orodispersible tablets. !n
comparison to 223 4 CC5a it showed acceptable results .The tablets containing CC5a
showed less time to disintegrates 4 also better dissolution as compared to 223 4 !ndion
$'$.
Dissolution study of all the prepared tablets showed near about '66 , drug release
within '7 minutes as compared with the marketed formulations within '8 minute and tablet
without superdintegrants gives released in ## min.
Overall study suggests that the !on echange resins have a great potential in the
formulation of taste masked Orodispersible tablets of Tramadol HCl. !t was concluded that
oro/dospersible tablet of Tramadol HCl can be sucessfully prepared using CC5a( 223 and
!ndion$'$ as superdisintegrant by direct compression method.
SUGGESTED FUTURE WORK
1urther optimi-ation of ratios for drug& resin complees
1urther characteri-ation of drug& resin complees.
9ccelerated stability study of the formulation.
!n vivo study of the drug& resin comple and formulation.
[Formulation development and evaluation of Oro-dispersible tablet by direct
compression Method] Page "