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EFEK HEPATOPROTEKTOR EKSTRAK ETANOL LIDAH

BUAYA (Aloe vera Linn.) TERHADAP GAMBARAN


HISTOPATOLOGI HATI TIKUS JANTAN PUTIH
(Rattus norvegicus) GALUR WISTAR YANG
DIINDUKSI PARASETAMOL
Novianus Erik Gibson
1
; Muhammad In'am Ilmiawan
2
; Heru Fajar Trianto

Abstr!
Ltr B"#!n$ % daun lidah bua!a "Aloe vera #inn$% men&andun& sen!awa
metabolit sekunder 'lavonoid !an& ber'un&si seba&ai sen!awa antioksidan dan
menstimulasi (embentukan &lutation "G)H% sehin&&a men*e&ah kerusakan
he(atosit akibat induksi (arasetamol dosis toksik$ T&'&n % (enelitian ini
bertujuan men&etahui e'ek he(ato(rotektor dan dosis e'ekti' ekstrak etanol lidah
bua!a "Aloe vera #inn$% (ada tikus (utih jantan &alur +istar dibandin&kan
kurkumin melalui indikator histo(atolo&i$ M"t()(#($i % (enelitian ini meru(akan
jenis (enelitian eks(erimental ran*an& a*ak len&ka( ",-#% den&an desain post
test. )eban!ak 2. ekor tikus (utih jantan &alur wistar diba&i se*ara a*ak ke
dalam / kelom(ok (erlakuan0 !aitu kontrol ne&ati' "(arasetamol%0 kontrol normal
"1M1 2034%0 kontrol (ositi' "kurkumin%0 dosis I "1222 m&5k&66%0 dosis II "2222
m&5k&66%0 dosis III ".222 m&5k&66% !an& diinduksi (arasetamol satu jam
kemudian0 (erlakuan selama 7 hari$ 8ata dianalisis men&&unakan uji 9ne:wa!
anova !an& dilanjutkan den&an Post Hoc Test #)8. Hsi# % 6erdasarkan skrinin&
'itokimia ekstrak etanol lidah bua!a "Aloe vera #inn$% men&andun& 'lavonoid0
alkaloid0 tanin0 sa(onin0 dan steroid$ Hasil analisa menunjukkan (erbedaan !an&
bermakna rerata derajat kerusakan he(atosit kelom(ok kontrol ne&ati' den&an
kelom(ok dosis I0 II0 dan III ekstrak etanol lidah bua!a "(;2023%$ Ekstrak etanol
lidah bua!a dosis .222 m&5k&66 meru(akan dosis e'ekti'$ K"si*+&#n %
Ekstrak etanol lidah bua!a "Aloe vera #inn$% memiliki kemam(uan dalam
men*e&ah kerusakan he(atosit akibat induksi (arasetamol dosis toksik (ada
tikus jantan (utih &alur wistar$ Ekstrak etanol lidah bua!a dosis 2222 m&5k&66
dan .222 m&5k&66 memiliki kemam(uan !an& sama den&an kurkumin dalam
men*e&ah kerusakan he(atosit$ Ekstrak etanol lidah bua!a dosis .222 m&5k&66
meru(akan dosis !an& (alin& baik dalam men*e&ah kerusakan he(atosit$ E'ek
he(ato(rotektor lidah bua!a didu&a karena aktivitas antioksidan 'lavonoid0 tanin0
alkaloid0 dan streroid !an& terkandun& dalam tanaman lidah bua!a$
<ata <un*i = #idah 6ua!a0 Histo(atolo&i0 he(ato(rotektor
1% >ro&ram )tudi >endidikan 8okter0 Fakultas <edokteran0 ?niversitas
Tanjun&(ura >ontianak0 <alimantan 6arat
2) 8e(artemen >atolo&i -natomi0 >ro&ram )tudi >endidikan 8okter0 Fakultas
<edokteran0 ?niversitas Tanjun&(ura >ontianak0 <alimantan 6arat
3) 8e(artemen Histolo&i0 >ro&ram )tudi >endidikan 8okter0 Fakultas
<edokteran0 ?niversitas Tanjun&(ura >ontianak0 <alimantan 6arat$
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HEPATOPROTECTOR EFFECT ETANOLIC EXTRACT OF ALOE VERA
AGAINST HISTOPATHOLOGY OF LIVER ALE !ISTAR RATS "Rattus
norvegicus# in$uce$ %araceta&ol'
Erik Novianus Gibson
1
; Muhammad In'am Ilmiawan
2
; Heru Fajar Trianto


Abstract
(ac)groun$* secondary metabolite of Aloe vera contains flavonoid that act as
antioxidants and could be expected to stimulate the production of glutathione
(GSH) thus preventing hepatocytes in!ury "hen being induced by toxic dose of
paracetamol.. O+,ective* This study aims to determine the hepatoprotective
effects and effective dose of ethanol extract of aloe vera (Aloe vera #inn.) $n
"hite male %istar rats compared to curcumin through histopathological
indicators. et-o$olog.* This study is an experimental research completely
randomi&ed design ('()) "ith post test design. A total of *+ male "hite rats of
%istar strain "ere randomly divided into six treatment groups the negative
control (paracetamol) normal controls (',' -../) positive control (curcumin)
dose 0 (1--- mg 2 3g) dose 00 (*--- mg 2 3g) dose 000 (+--- mg 2 3g) then
induced by paracetamol an hour later treated for 4 days. The data "ere
analy&ed using $ne5"ay A6$7A test follo"ed by #S) Post Hoc Test. Results*
8ased on the phytochemical screening of ethanol extract of aloe vera (Aloe vera
#inn.) it contains flavonoids al3aloids tannins saponins and steroids. The
results of the analysis sho"ed a significant difference mean degree of
hepatocyte damage on negative control compared to the group "ith dose 0 00
and 000 of the ethanol extract of aloe vera (p 9-.-.). :thanol extract of aloe vera
"ith +--- mg 2 3g dose is an effective dose. Conclusion* The ethanol extract of
aloe vera (Aloe vera #inn.) Has the ability to prevent hepatocytes damaged that
induced by toxic dose of paracetamol on "hite male rats "istar strain. :thanol
extract of aloe vera "ith *--- mg 2 3g and +--- mg 2 3g dose have the same
ability "ith curcumin in preventing hepatocytes damage. :thanol extract of aloe
vera of +--- mg23g is the most effective preventing hepatocytes damage.
Hepatoprotective effects of aloe vera allegedly due to the antioxidant activity of
flavonoids tannins al3aloids and streroid that contained in the aloe vera plant.
;ey"ords< Aloe vera. Histopathology hepatoprotective
1) ,edical :ducation Program =aculty of ,edicine >niversity of Tan!ungpura
Pontiana3 %est ;alimantan
*) )epartment of Anatomical Pathology ,edical :ducation Program =aculty of
,edicine >niversity of Tan!ungpura Pontiana3 %est 8orneo.
?) )epartment of Histology ,edical :ducation Program =aculty of ,edicine
>niversity of Tan!ungpura Pontiana3 %est 8orneo.
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