Mhealth PRESENTATION LifeScience+cluster 15102013

2013 Tampere Region Economic Development Agency Tredea Ltd.
Tredea cluster information materials - 7 key clusters:

Intelligent Machines, Life Science, ICT, Manufacturing Industry
+ in process: Creative Business Industries, Cleantech, Nanotech, Energy
Life Science (Healthtech+Biotech)
1. Short presentation = Cluster Description: key figures, key actors, key
arguments
2. Background material: top 20 companies, key research institutes + their
projects
3. Backgound material: company list (92) incl. Key figures (turnover,
turnover growth%, employees), competences, offering, contacts
From april to end of June 2013
Interviews (35 companies+organisations )
Round Table 7.6.2013
Statistics/company data from: Taloussanomat, Tilastokeskus, Toimiala
on-line, FiHTA, FIB

Key questions:
Cluster Definitions - The relevance of defining?
Cluster Development/Cluster Policy the Relevance?
How can we use this information?
How can it benefit the business in Tampere region?

Questions
1. Finland
- Focus on High Technology Industries
2. Tampere Area
- Good in Size
- Smooth Collaboration between Research and Business
3. Key Players
4. Core Competences
5. Life Science Cluster
- Cross Sectoral Business
6. Core R&D
- 3 Universities, 12 Research Institutes and Centres of Expertise
7. Local and Global Networks
8. Summary: Why Tampere?

- High level education system (TOP ranking in PISA
studies)
- Excellent availability of scientists and engineers
- Good public innovation platforms and funding
- National public funding on solutions
for biological information (e.g. 10M BioIT
Programme 2013-2015)
- Private investments on Life Science
companies 65M (2012)
- Transparent and effective national regulation,
licensing, and legislation
- Rocketing health tech export: 1,65 billion in
2012. Annual growth (2011-2012) 23 % (not incl. R&D
labour and services)
- Health technology is appr. 2,5 billion 2012
business in Finland (combined turn over of members of
Finnish Health Technology Association)

Finland = Safe, well organized, smooth and functional
infrastructure, transparent public administration.
350 M annual public funding on health sector R&D.

Source: Ministry of Employment and Economy
Technology Industries are the most
important industrial sector in Finland:
60% of total Finnish exports
80% of total Finnish R&D-investments
290 000 directly employed in the sector, total
employment effect around 700 000, equalling a
quarter of the Finnish workforce.
Source: The federation of Finnish Technology Industries
"The modern way of life presents a hazard to our well-being. By using
our skills in mobile technologies and behavior science, we can do a lot
to make people to change their health behavior for better. "
Movendos Oy, Arto Leppisaari, CEO
Our strenghts:
Unique combination of Bio Medi
Tech expertise in research and
education
Cutting edge medical development
in Personalized Medicine and
Human spare parts
Expertise in Connected Health:
Strong ICT & Medical Engineering
Cross sectoral health services and
service know how

"Tampere is one of the few places in the
world where biosciences and technology
work together in such a close
connection."
Technical University of Tampere,
Jukka Lekkala, Professor
Because we have:
Good size enabling smooth collaboration
Functionable infrastucture making it easy to do
business and research
Skilled and motivated personnel available for
fluent recruitment
BioMediTech - A pioneering research and
educational environment combining
biosciences and technology

Tampere - First in Finland and
Northern Europe:
1783: 1st paper mill
1842: 1st paper machine
1882: 1st electric light in
Northern Europe
1974: 1st Biomedical chairs in Finland
2006: 1st clinical cranial bone fixation
derived from patients own fat
tissue in the world

Tampere Today:
Fastest growing region in Finland
Up to 15% of Finland's national
R&D budget is spent here
with the population of 490 000
- the largest region in Finland just
after the Helsinki capital region
For an investor, the size of Tampere provides
an advantage. Things run smoothly, and
investors can be personally involved in
shaping their business environment.
- Jyrki Liljeroos, CEO Santen Ltd
Tekes, BioIT
programme, ELY-
center
B-to-b, b-to-c, b-to-b-to-c
Devices, ICT, Software,
Integration, Pharma, Services,
Biomaterials
Patient hotel, Senior housing service
concept, Private hospital and health
services , Sports institutes

New Factory business
incubator: Protomo,
Demola, Suuntaamo
mHealth network
Data Driven
Medicine conf
CLUSTER
COORDINATION
AND NEW
INNOVATION
PLATFORMS
FinnMedi Innovation,
Growth, Clinical
FUNDING AND EXPERTISE
100+ COMPANIES
LINKED SERVICE PROVIDERS
ENABLERS AT
SCIENCE PARK KAUPPI
Hermia Ltd

FinnMedi Ltd.
RESEARCH AND EDUCATION
Tampere University of
Technology, TUT
University of
Tampere, UTA
Institute of Biosciences and Medical
Technology, BioMediTech
Tampere University of
Applied Sciences, TAMK
VTT Technical
Research
Centre of
Finland
The Pirkanmaa
Hospital District,
Science Center
Coxa
Hospital
for Joint
Replacement
UKK Institute, Centre for Health
Promotion Research
Heart Center
Tampere University Hospital,
TAUH

Research and
Development Center for
Ophthalmic Innovations,
SILK
Research Centers:
FICAM, GEREC ,
TACC, Regea,
FinMIT, Vaccine
Research

National Institute for Health
and Welfare/Tampere
KEY COMPETENCES APPLICATION AREAS BUSINESS EXAMPLES
Stem cells
Cell and tissue
Biomimetic environments
Biomaterials and biosensors
Implantable spare parts
In vitro drug discovery
Biodegradable materials
Ozics
Bioretec
Scaffdex

Signal and image processing
ICT and SW engineering
Computational systems
biology
Monitoring and imaging
Sensor and measurement solutions
Connected health
Bionavis
Physiotools
Mylab

Health informatics
Health care processes
Rehabilitation and training
Gerontology
Wellness and health care systems
Specialized health care units
Assistive technologies
Treatment and care
Coxa
Norlandiacare
Instainnovation
Drug development
Immunology & gene
Clinical research
Vaccines
Ophthalmology medicine
Mitochondrial genetics
Cancer
Santen
Vactec
FitBiotech
Human
spare parts
Biomedical
systems and
devices
Health
services
Medicines
Universities and research institutions Innovation platforms University hospital Research centers &institutes
Stem Cells
and
Tissues
Biosensors
Bio-
mimectic
environ-
ment
Immuno-
logy &
Gene
Drug
Develop-
ment
Clinical
reseach
Bio-
materials
Electronics
Microscale
Techno-
logies
ICT &
Signal
Processing
Health
Infor-
matics
Health
Care
Processes
Rehab,
Training &
Geronto-
logy
Implantable
spare parts
Cell & tissue
center and data
base
In vitro drug
discovery
Biodegradable
materials
Vaccines
Mitochondrial
genetics
Ophthalmology
medicine
Assistive
technologies
Wellness and
health care
systems
Personal health
informatics
Connected
Health
Computational
Biology
Specialized
health care
units
Treatment and
care
Sports and
wellness
tourism
Human
Spare Parts
Biomedical
systems and
devices
Medicines
Health
Services
Biobanks
Sensor and
measurement
solutions
Monitoring and
Imaging
Ophthalmic
medicines and
methods
Santen.fi
Preclinical
vaccine dev.
and biobanking
Vactec.fi
DNA plasmids,
HIV-vaccine dev.
Fitbiotech.com
Biocomposite
implants in sports
medicine
Conmed.com
Insta Care situational
awareness system
Instainnovation.fi

Coxa Focus
Hospital for Joint
Replacement
Coxa.fi
Patient Hotel
Norlandiacare.no
Custom assistive
devices and
related services
incl. prosthesis
Respecta.fi
SPR Surface
Plasmon
Resonance
Bionavis.com
Software for
personalised
exercise handouts
Physiotools.com
iPana birth
information
platform
Mediware.fi
Balance Trainer
Platform
Hurlabs.com
Mobile coaching
solution
Movendos.com
Biomaterials and
implants for
mending bones
Ozics.com
Bioabsorbable
implants and
devices for surgery
Bioretec.com
App for
sports&training
Sports-tracker.com
App for
sports&training
Trelab.fi
Healthcare
information
services
Mylab.fi
Biodegradable
solutions to surgery
Inion.com
Phrenic nerve
stimulators
Atrotech.com
Human
Spare Parts
Biomedical
systems and
devices
Medicines
Health
Services
Biomaterials

ICT & Signal
Processing
Drug Development

Ophthalmology
medicine
Santen Pharmaceutical specializes in the research,
development, manufacturing and marketing of
ophthalmic and anti-rheumatic pharmaceuticals to
protect and improve people's eyesight and health.
Santen.fi
Health Care
Processes

Connected
Health
Specialized
health care
units
Biodegradable
materials
Movendos Ltd is a start-up developing mobile tools
for personal health & wellness coaching. With this
tool coaches can follow customers progress, motivate
them and measure the effectiveness of coaching in
real time. Movendos is a spin-off from TUT personal
health research. Movendos.com
Coxa Hospital for Joint Replacement is a health care
pilot company, a focus hospital, founded in 2002.
Coxa has cutting edge expertise in both joint
replacement surgery and research.
Coxa.fi
Bioretec Ltd manufactures and develops advanced
bioabsorbable implants and device solutions for
various fields of surgery. Bioretecs Activa products
are novel bioabsorbable fixation devices for
treatment of bone ligament and cartilage fractures.
Bioretec.com
Human Spare Parts
Health Services
Biomedical systems
and devices
Medicines
Tampere
Region:
Life Science Industries
(Bio and Health Technology)
Technology Industries (total)
Companies 100 2 700
Employees 2 000 34 400
Turn over 436 m 7 751 m
(source: local estimation based on public company
data 2012, and interviews)
(source: The Federation of Finnish Technology
Industries)
FACT FILE: Tampere
Good size
90 min accessibility - logistically excellent
The oldest industrial town in Finland:
Industry-oriented
Business friendly
Easy to reach by car, by train, by airplane

Cutting edge expertise in:
Biomaterials
Biodegradable materials
Regenerative medicine and stem cell technology combination of
Biomaterials
Sensors
Imaging
Cellular biology
Signal and image processing in biomedical applications
Personal health informatics and m-health
Cell technology
Computational system biology
Personal medicine

" Here in Tampere, having access to extensive
patient material and follow-up data, we have
excellent opportunities for research."
-Coxa Oy, Tarmo Martikainen, CEO
Cross-disciplinary co-operation environment
where engineers, biologists, and medical
experts work together.
Innovation. Tampere innovation
platforms:
Supporting start-up and growth of the
companies
FinnMedi
New Factory, Protomo
Enablers. Early testing environments
Tampere University Hospital
Heart Center
SILK R&D Center for Ophthalmic
Innovations
Coxa Hospital for Joint Replacement
Business. Tekes and other national
support systems
From research to business
Active start-up scene
"Tampere has many logistical benefits for our
supply chain: fast deliveries from our central
warehouse, skilled workforce with health care
certificates, standardised and certified
products, and the backing of up-to-date
research."
-Respecta Oy, Satu Forsman, Area Manager
Finn-Medi Science Park,
Kauppi campus
International level research
Universities and research institutes
Fidipro programme to invite
international experts to
Tampere universities
National research programmes
Shok-cooperation (Salwe, Tivit)
Finnish Academy
Tekes
Cross-disciplinary research and education
Joint education programme including engineering, biological
and medical studies
BioMediTech research coordination
Specialized research centers
Coxa Hospital for Joint Replacement, FICAM Finnish Centre for Alternative Methods, Heart Center,
Regea Cell and Tissue Center, Science Center at the Pirkanmaa Hospital District, SILK Research
and Development Center for Ophthalmic Innovations, Surgery Training Center, Vaccine Research
Center

"The expanding, global industry of health care
technologies has a hub of expertise here in
Tampere.- VTT Technical Research Centre of
Finland , Niilo Saranummi, professor

Technical research
centre of Finland
Mining and fusion of human data
Mobile health and wellness
applications
Health information systems
Health Tourism
Health Gaming
Social Robotics
Usability testing and living labs
Immunology
Cell and tissue, Stem cells
Gene and protein technology
Gerontology
Regenerative medicine
Vaccines
Vision and Ophthalmology
Image and signal processing
Biomaterials and biosensors
Computational systems biology
SW engineering, User interfaces
Micro- and nanoscale technologies
Personal health informatics
University
of Tampere
Technical research
centre of Finland,
Tampere
Tampere University
of Applied Sciences

Unipoli Tampere Agreement (since 2006) Active mentoring programmes
COMPANIES
FinnMedi Research
Joint institute of
University of Tampere and
Tampere University of Technology
Combination of engineers,
biologists and clinicians
Strategic research in biomedicine
and medical technology
Researchers : 250+
Profs: 20
Researchers: 200
Students: 100 (total 10 400)
Profs: 50
Researchers: 300
Students: 800 (total 16 000)
Researchers : 30 (total 340) Students: 500 (total 10 000)
Information processing, modelling and control
User interface, user experience, usability
Materials and devices
Biomaterials, biosensors, microscale technologies
Electronics, mechanics, physics, chemistry
Medicine
Microbiology, immunology
Virology, Vaccines
Health sciences
Biostatistics, Cancer, Ageing
Strategic multi-disciplinary research
combining
Engineers
Clinicians
Biologists
Human data mining
Biosignal and image analysis
Mining and fusion of heterogeneous data
Connected health
Mobile health and wellness applications
Medical and wellness technologies
Biomedical Laboratory Sciences
Wellness technology
Health care practices
Physiotherapy
Medicine
Virology, Vaccines
Health sciences
combining
Engineers
Clinicians
Biologists
Human data mining
Connected health
Wellness technology
Physiotherapy
To develop solutions leading in the future to
new therapies and drug screening technologies
such as:
Bone transplants
Cardiac cell and tissue models
for studying genetic heart diseases and drug
development.

Combines top-level
expertise in
biomaterials, sensor
technology, biomedical
engineering and
stem cells
Human Spare Parts Program
Medicine
Virology, Vaccines
Health sciences
combining
Engineers
Clinicians
Biologists
Human data mining
Connected health
Wellness technology
Physiotherapy
Mimicking human in vivo conditions (normal
and diseased)
Understanding stem cell biology
Understanding disease mechanisms
Studying effects of chemical compounds
Technologies for
measuring and
controlling the
conditions in the cell
microenvironment
Biomimetic Cell Cultivation
Environments
TAMPERE UNIVERSITY OF TECHNOLOGY
Department of Automation Scienceand Engineering
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Biomimetic Cell Cultivation Environment
- Objective
To develop a miniaturized cell
cultivation environment
mimicking the human in vivo
conditions (normal and
diseased)
Temperature
Nutrient supply
Oxygen supply
Drug compound supply
Particularly for cardiac and
neuronal cells
Compatible with Micro
Electrode Arrays (MEA)
Medicine
Virology, Vaccines
Health sciences
combining
Engineers
Clinicians
Biologists
Human data mining
Connected health
Wellness technology
Physiotherapy

Signal and image processing methods for
automatic analysis of 3D functional images
Computational modeling and sensing of tissue
engineered and physiological systems
Automatic methods for the analysis of brain
images
Neuroinformatics combines neuroscience and
informatics research to develop tools to
understand the structure and function of the
brain

Developing methods
and software for
processing and
analysing of properties
and functionality of
biological systems
through imaging and
modeling
Image Analysis and Modeling
Medicine
Virology, Vaccines
Health sciences
combining
Engineers
Clinicians
Biologists
Human data mining
Connected health
Wellness technology
Physiotherapy
Objective and strictly evidence based analysis,
Integrates heterogeneous biomarkers from blood
samples, imaging data (MRI+PET), TMS/EEG and
clinical tests
Estimates disease severity not just provide a
classification and works with incomplete data
Currently being tested for clinical use in several
trials, licensed to commercial use and in use in
several research projects
Development of
novel biomarkers
and analysis
software for early
diagnosis of the
Alzheimer's
disease
PredictAD: Decision Support System
Medicine
Virology, Vaccines
Health sciences
combining
Engineers
Clinicians
Biologists
Human data mining
Connected health
Wellness technology
Physiotherapy

Giving patients tools to gather, manage, analyse
and communicate their health information
between other patients and health professionals
Personal health monitoring
Personal data management (PHR)
Personal analysis and feedback
Connectivity
Monitoring + Communication + Data
Interpretation + UX + SW engineering + Business
Model

Design health
technologies for
consumer.

People as co-
producers of health
and care
10 22/04/2013
Reactive
Proactive
Health & Care
Professionals
Citizen-
Patient
C
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n
n
e
c
t
e
d

H
e
a
l
t
h

c
h
o
i
c
e
s

Dependency
Patients as
passive objects
Individuals as
co-producers of
Health & Care
A new role for citizens and patients
People as co-producers of health and care
Traditional
Model
Co-Producer Model
Illness Management of health and
care
Outsourced Insourced
Reactive Proactive
Episodic Continuous
GPs and
Hospitals
Value based business
models (shops, retail
clinics, value-added
processes, user networks)
Fee for
Service
Value based
reimbursement
Consumer Health Informatics
Medicine
Virology, Vaccines
Health sciences
combining
Engineers
Clinicians
Biologists
Human data mining
Connected health
Wellness technology
Physiotherapy

Biodegradable materials are used as drug carriers
to allow for the drug to be released directly into
the bloodstream to make it available to the
whole body, or locally into the damaged tissue.
Materials can be employed to treat diseases that
require the use of multiple drugs.
Can also be used to repair tissue
Implant acts both as a drug-release device
and as a cell scaffold.
Targeted drug
delivery through
new biodegradable
materials that
release drugs to the
human body

Drug Delivery and
Biodegradable Materials
Medicine
Virology, Vaccines
Health sciences
combining
Engineers
Clinicians
Biologists
Human data mining
Connected health
Wellness technology
Physiotherapy
TAMK Tampere University of
Applied Sciences
R&D focus in Bio and Health
Technology:
Health tourism
Technologies and services for senior citizens
Health gaming and social robotics
Young athletes wellness programme
ITSE- and UNI-Living labs for testing
usability of tools, devices and technologies
related on sleep and housing

TAMK offers Bachelor and Master level studies for 10 000
students in seven educational fields. The education focuses
on technology, business and wellbeing services.
Focus Hospitals:
Coxa Hospital for Joint Replacement: 173 specialist of which 18 doctors. Scientific research and
development work on joint replacement surgery, related processes and therapies. www.coxa.fi
Heart Center: 300 specialists of which 50 doctors. Scientific research focusing on development of
angioplasty techniques and enhanced protection of the heart during cardiac surgery, patients
post-operative quality of life, and magnetic navigation system (NiobeStereotaxis ).
www.sydankeskus.fi
Research Centers :
FinMIT The Academy of Finland Centre of Excellence conducts research on mitochondrial disease
and ageing in institute of Biomedical technology at University of Tampere. www.uta.fi/ibt/finmit
Regea Cell and Tissue Center is a clinical tissue bank processes and supplies tissues for clinical use
in institute of Biomedical technology at University of Tampere. Regea also produces adipose tissue
derived stem cell products for the treatment of bone defects. www.regea.fi
SILK Research and Development Center for Ophthalmic Innovations at the University of Tampere:
coalition of 60 specialists focusing on proteomics of personalized medicine, imaging techniques,
stem cell technology and clinical research of the eye. http://www.silkresearch.fi/
Science Center at the Pirkanmaa Hospital District: Supporting researchers all the way from
planning to clinical phase and from finance and juridical advicing.
Surgery Training Center: Surgical training specializing on tissue and joint surgery - The only high
level surgical education center in Northern Europe.
The UKK Institute Centre for Health Promotion Research: R&D projects to generate information
on the health benefits and promotion of physical activity. http://www.ukkinstituutti.fi/en/research

Research Centers within the University of Tampere:

Finnish Centre for Alternative Methods, FICAM : focuses on the
development and validation of cell and tissue culture 2D and 3D models to
complement and replace animal tests. http://www.ficam.fi/
Gerontology Research Center, GEREC: produces new scientific
knowledge for the aging society, contributes to academic training and
increases expertise in the field of aging. A joint institute with the University of
Jyvskyl.
Tampere Center for Child Health, TACC : (est.2012) 100 staff members
and research students. TACC brings together laboratory scientists,
psychologists, social scientists, public health specialists as well as clinicians
from paediatrics, child psychiatry and other medical specialties. TACC
carries out multidisciplinary research with a wide range of methodologies,
aiming at improved means to promote and resume healthy growth among
infants and children worldwide.
Vaccine Research Center: 130 professionals forming a clinical research
unit operating within the University of Tampere Medical School. It carries out
clinical trials of vaccines in co-operation with the pharmaceutical industry.
http://rokotetutkimus.fi

FinnMedi Ltd: Networking, business development and clinical
research in the Life Sciences sector. http://www.finnmedi.fi
Innovation and growth services for companies and research groups
Coordination of National expertise programmes focusing on health
applications of biotechnology and on business areas related to health
and well-being.
Hermia Ltd: Networking and acceleration of expertise in
technology industry. http://www.hermia.fi/
Nanotechnology cluster programme focusing on fotonics
and future composite materials.
Joint networking with FinnMedi: Data Driven Medicine conference and
mHealth Tampere Network
FIB Finnish Bioindustries: Finland's biotechnology industry association representing
all life science areas, from health care and functional food to biomaterials.
http://www.finbio.net/en/finnish-bioindustries
FiHTA The Finnish Health Technology Association: is the association for all Finnish companies in the
health technology business. http://www.finnishhealthtech.fi/
The European Connected Health Alliance (ECHAlliance): Comprising companies, health and social
care providers and research organisations across Europe.
TAMPERE ALL BRIGHT!
Where engineers,
biologists and clinicians
collide.

Excellence in research
Good size for smooth
collaboration
Unique multidisciplinary high
level education
Competitive business
development
Highly skilled professionals
available

"We are convinced that in the near future, by
means of technological expertise, Tampere
will provide a pioneering solution to welfare
problems caused by the aging population."
- Insta Innovation Oy,
Esa Einola, Vice President
CONTACT: Mr Petri Nyknen
petri.nykanen@tredea.fi
Director, Business Development and Invest in
Tampere Region Economic Development Agency Tredea
CONTACT: Mr Reijo Itkonen
reijo.itkonen@finnmedi.fi
Director, Business Development
Finnmedi

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2013 Tampere Region Economic Development Agency Tredea Ltd.

Tredea cluster information materials - 7 key clusters:

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