Staff of Pathology Division: Staff of Pathology Division:

EKW, DRA, SES, EVH, WWN, BPP, HAHA, ASO, MSB

VETNIZAH J UNIANTITO VETNIZAH J UNIANTITO
PATOLOGI SISTEMIK II (PAP 442) PATOLOGI SISTEMIK II (PAP 442) PATOLOGI SISTEMIK II (PAP 442) PATOLOGI SISTEMIK II (PAP 442)
PATOLOGI ALAT REPRODUKSI PATOLOGI ALAT REPRODUKSI
ALAT KELAMIN JANTAN ALAT KELAMIN JANTAN ALAT KELAMIN JANTAN ALAT KELAMIN JANTAN
Dr. drh. Eva Harlina, MSi. Dr. drh. Eva Harlina, MSi.
Bagian Patologi Bagian Patologi
Departemen Klinik, Reproduksi dan Patologi Departemen Klinik, Reproduksi dan Patologi
Fakultas Kedokteran Hewan Fakultas Kedokteran Hewan IPB IPB Fakultas Kedokteran Hewan Fakultas Kedokteran Hewan--IPB IPB
Jl. Agatis Kampus IPB Darmaga, Bogor Jl. Agatis Kampus IPB Darmaga, Bogor -- 16680 16680
MALE REPRODUCTIVE SYSTEM MALE REPRODUCTIVE SYSTEM MALE REPRODUCTIVE SYSTEM MALE REPRODUCTIVE SYSTEM
Testis Testis
Excretory duct Excretory duct
Accessory glands Accessory glands Accessory glands Accessory glands
Penis and prepuce Penis and prepuce p p p p
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MALE REPRODUCTIVE SYSTEM MALE REPRODUCTIVE SYSTEM
Testis Testis
Seminiferous tubules (contain germcells Seminiferous tubules (contain germcells Seminiferous tubules (contain germ cells Seminiferous tubules (contain germ cells
in various stage of maturation), Sertoli in various stage of maturation), Sertoli
cell Leydig cells cell Leydig cells cell, Leydig cells cell, Leydig cells
Excretory duct Excretory duct: epididymis, vas deferens : epididymis, vas deferens
Accessory glands Accessory glands: seminal vesicles, : seminal vesicles,
prostate prostate
Penis and prepuce Penis and prepuce
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Patologi Alat Kelamin J antan 4 Patologi Alat Kelamin J antan 4
Patologi Alat Kelamin J antan 5 Patologi Alat Kelamin J antan 5
Patologi Alat Kelamin J antan 6 Patologi Alat Kelamin J antan 6
DISEASES OF THE MALE DISEASES OF THE MALE
REPRODUCTIVE SYSTEM REPRODUCTIVE SYSTEM
Developmental disorders Developmental disorders
Diseases of the scrotum and contents Diseases of the scrotum and contents
Diseases of the accessory glands Diseases of the accessory glands Diseases of the accessory glands Diseases of the accessory glands
Diseases of the penis and prepuce Diseases of the penis and prepuce
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DEVELOPMENTAL DISORDERS DEVELOPMENTAL DISORDERS DEVELOPMENTAL DISORDERS DEVELOPMENTAL DISORDERS
MAJ OR ANOMALIES MAJ OR ANOMALIES MAJ OR ANOMALIES MAJ OR ANOMALIES
Sexual dimorphism Sexual dimorphism pp
Segmental aplasia of epididymis Segmental aplasia of epididymis
Cryptorchidism Cryptorchidism
Testicular hypoplasia Testicular hypoplasia Testicular hypoplasia Testicular hypoplasia
Spermatic granuloma Spermatic granuloma
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SEXUAL DIMORPHISM SEXUAL DIMORPHISM
Errors of Errors of chromose chromose, , gonadal gonadal or phenotypic sex or phenotypic sex
1. Sex chromosomes (structure and number). 1. Sex chromosomes (structure and number).
a. Abnormal structure of Y a. Abnormal structure of Y ((isochromosome isochromosome))
FFemale phenotype emale phenotype
H l ti H l ti dd Hypoplasctic Hypoplasctic gonads gonads
b. b. Duplicationof one of the sex chromosome Duplicationof one of the sex chromosome b. b. Duplication of one of the sex chromosome Duplication of one of the sex chromosome
(XXY, XYY) (XXY, XYY)
Testicular Testicular hypoplasia hypoplasia
Kli f lt Kli f lt d (t i l l t) d (t i l l t) Klinefelters Klinefelters syndrome (tricolor male cat) syndrome (tricolor male cat)
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SEXUAL DIMORPHISM SEXUAL DIMORPHISM
22 Hermaprhodites Hermaprhodites 2. 2. Hermaprhodites Hermaprhodites
XY genotype XY genotype
Androgen receptor disorder Androgen receptor disorder
Abnormal gonads (have both Abnormal gonads (have both g ( g (
testicular and testicular and ovarium ovariumtissue= tissue=
Ovotestes Ovotestes
Canine, porcine, Canine, porcine, caprine caprine, bovine , bovine
freemartin freemartin
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SEXUAL DIMORPHISM SEXUAL DIMORPHISM
3. Male 3. Male Pseudohermaprhodites Pseudohermaprhodites pp
Abnormal phenotypic sex Abnormal phenotypic sex
XY t XY f l ( i XY t XY f l ( i XY genotype XY female rare (mice, XY genotype XY female rare (mice,
horses, human being): horses, human being): stroma stroma
ovarium ovarium ovarium ovarium
Reproductive tract: ambiguous Reproductive tract: ambiguous
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Male pseudo- Male pseudo
hermaphrodite: XY
chromosome
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Patologi Alat Kelamin J antan 12 Patologi Alat Kelamin J antan 12
MINOR ANOMALIES MINOR ANOMALIES
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MINOR ANOMALIES MINOR ANOMALIES MINOR ANOMALIES MINOR ANOMALIES
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DISEASES OF THE SCROTUM DISEASES OF THE SCROTUM DISEASES OF THE SCROTUM DISEASES OF THE SCROTUM
AND CONTENTS AND CONTENTS
The scrotum The scrotum The scrotum The scrotum
T i d E idid i T i d E idid i Testis and Epididymis Testis and Epididymis
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DISEASES OF THE SCROTUM DISEASES OF THE SCROTUM
Dermatitis Dermatitis
TTTrauma Trauma
Frosbite Frosbite
E i t l i it t E i t l i it t Environmental irritants Environmental irritants
Chorioptes bovis Chorioptes bovis
Neoplasma Neoplasma pp
Mast cell tumor Mast cell tumor
Melanoma Melanoma
Hemangioma Hemangioma
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Patologi Alat Kelamin J antan 16 Patologi Alat Kelamin J antan 16
Patologi Alat Kelamin J antan 17 Patologi Alat Kelamin J antan 17
DISEASES OF TESTIS AND DISEASES OF TESTIS AND
EPIDIDYMIS EPIDIDYMIS
Decreased size Decreased size
C t hidi C t hidi Cryptorchidism Cryptorchidism
Hypoplasia Hypoplasia yp p yp p
Testicular degeneration Testicular degeneration
Segmental aplasia Segmental aplasia
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Increased size Increased size
Spermatic granuloma of epididymis Spermatic granuloma of epididymis
Epididymitis Epididymitis
Orchitis Orchitis
Testicular neoplasia: Testicular neoplasia:
Seminoma Seminoma
Sertoli cell tumor Sertoli cell tumor
Interstitial cell tumor Interstitial cell tumor
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CRYPTORCHIDISM CRYPTORCHIDISM
Decreased size Decreased size
Incomplete descent of testis Incomplete descent of testis
Oft il t l Oft il t l Often unilateral Often unilateral
Hypoplasia Hypoplasia or atrophy or atrophy yp p yp p p y p y
Testis is small, fibrotic, hyaline thickening Testis is small, fibrotic, hyaline thickening
of tubular basement membrane, of tubular basement membrane, of tubular basement membrane, of tubular basement membrane,
degeneration of germinal epithelium, only a degeneration of germinal epithelium, only a
few few spermatogonia spermatogonia remain, normal remain, normal Sertoli Sertoli
ll ll cells cells
Prone to Prone to neoplasia neoplasia ((Sertoli Sertoli CT, CT, seminoma seminoma)) pp (( ,, ))
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HYPOPLASIA HYPOPLASIA
Decreased size Decreased size
Mild to severe Mild to severe Mild to severe Mild to severe
Unilateral Unilateral hypoplasia hypoplasia
Abnormality of specific genes, endocrine, Abnormality of specific genes, endocrine,
cytogenic cytogenic
Related to poor general nutrition, Zn Related to poor general nutrition, Zn deff deff
HP: HP: hypoplastic hypoplastic tubules lined by tubules lined by sertoli sertoli HP: HP: hypoplastic hypoplastic tubules, lined by tubules, lined by sertoli sertoli
cells, a few stem cells and cells, a few stem cells and spermatogonia spermatogonia
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Patologi Alat Kelamin J antan 24 Patologi Alat Kelamin J antan 24
TESTICULAR ATROPHY TESTICULAR ATROPHY
Decreased size Decreased size
Reduce in size after puberty Reduce in size after puberty
Testicular degeneration Testicular degeneration Testicular degeneration Testicular degeneration
HP: deg. of the HP: deg. of the seminiferous seminiferous tubules tubules
Causes by: inflammation obstruction of Causes by: inflammation obstruction of Causes by: inflammation, obstruction of Causes by: inflammation, obstruction of
flow of spermatozoa (segmental flow of spermatozoa (segmental
aplasia aplasia injury of injury of epididymis epididymis torsion of torsion of aplasia aplasia, injury of , injury of epididymis epididymis, torsion of , torsion of
spermatic cord) spermatic cord)
Systemic injurious factor: Systemic injurious factor: Systemic injurious factor: Systemic injurious factor:
hypovitaminosis hypovitaminosis A, Zn, antibiotic, A, Zn, antibiotic,
toxins, estrogen produced by toxins, estrogen produced by sertoli sertoli cell cell
tumor tumor
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Some Causes of Testicular Degeneration Some Causes of Testicular Degeneration
Advancing age Advancing age
Epididymitis Epididymitis
Chemicals Chemicals
Heat Heat
Hormones Hormones Hormones Hormones
Metal compound toxicosis Metal compound toxicosis
Neoplasia Neoplasia
Nutritional disorders Nutritional disorders Nutritional disorders Nutritional disorders
Plants Plants
Radiation Radiation
Stress Stress
Trauma Trauma
Ultrasound Ultrasound Ultrasound Ultrasound
Viral infection Viral infection
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EPIDIDYMITIS AND EPIDIDYMITIS AND
SPERMATIC GRANULOMA SPERMATIC GRANULOMA
Inflammation, testicular Inflammation, testicular neoplasia neoplasia
SPERMATIC GRANULOMA SPERMATIC GRANULOMA
Inflammation, testicular Inflammation, testicular neoplasia neoplasia
Spermatic Spermatic granuloma granuloma: congenital : congenital
obstruction inflammation as obstruction inflammation as respon respon to to obstruction, inflammation as obstruction, inflammation as respon respon to to
spermiostatis spermiostatis
Epididymitis Epididymitis is almost accompanied by is almost accompanied by
spermatic spermatic granuloma granuloma and and periorchitis periorchitis
Cause testicular degeneration Cause testicular degeneration
BB abort s abort s E coli E coli B. B. abortus abortus, E. coli , E. coli
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Increased size Increased size c eased s e c eased s e
Spermatic Spermatic granuloma granuloma of of epididymis epididymis
Epididymitis Epididymitis
Orchitis Orchitis Orchitis Orchitis
Periorchitis Periorchitis
Testicular Testicular neoplasia neoplasia
Seminoma Seminoma Seminoma Seminoma
Teratoma Teratoma
Sertoli Sertoli cell tumor cell tumor
Interstitial cell tumor Interstitial cell tumor
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Patologi Alat Kelamin J antan 32 Patologi Alat Kelamin J antan 32
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Patologi Alat Kelamin J antan 34 Patologi Alat Kelamin J antan 34
ORCHITIS ORCHITIS
Extension of epididymitis Extension of epididymitis
Hematogenous Hematogenous
B b t B i B b t B i B. abortus, B. suis, B. abortus, B. suis,
C. pseudotuberculosis C. pseudotuberculosis
Intratubular orchitis, Intratubular orchitis,
necrotizing orchitis, necrotizing orchitis,
l t hiti l t hiti (M b i (M b i granulomatous orchitis granulomatous orchitis (M. bovis, (M. bovis,
mycotic orchitis mycotic orchitis))
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TESTICULAR NEOPLASIA TESTICULAR NEOPLASIA
Common in older dog Common in older dog
TESTICULAR NEOPLASIA TESTICULAR NEOPLASIA
gg
Arise from germ cells Arise from germ cells
Seminoma Seminoma
I t titi l ll t I t titi l ll t Interstitial cell tumors Interstitial cell tumors
Sertoli cell tumors: feminizing effect Sertoli cell tumors: feminizing effect Sertoli cell tumors: feminizing effect Sertoli cell tumors: feminizing effect
((Gynecomastica Gynecomastica: enlargement of : enlargement of
mammary gland) mammary gland)
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