Important lab tests for vascular system disorders: Platelet count Normal PT Normal APTT Normal Template BT Normal or abnormal INHERITED VASCULAR DISORDERS Hereditary hemorrhagic telangiectasia (HHT) Ehlers-Danlos syndromes PLATELET DISORDERS QUANTITATIVE PLATELET DISORDERS Thrombocytopenia Important lab tests for thrombocytopenia: Platelet count Decreased PT Normal APTT Normal Template BT Abnormal Due to increased destruction By the immune system Immune thrombocytopenic purpura (ITP) Neonatal alloimmune thrombocytopenia (NAIT) Heparin-induced thrombocytopenia (HIT) By consumption Disseminated intravascular coagulation (DIC) Thrombotic thrombocytopenic purpura (TTP) Hemolytic uremic syndrome (HUS) Due to decreased production By megakaryocyte hypoplasia syndromes Decreased megakaryocyte proliferation A type of aplastic anemia Fanconi anemia Thrombocytopenia with absent radii (TAR) syndrome By hereditary thrombocytopenia Wiskott-Aldrich Syndrome Bernard-Soulier (giant platelet) syndrome May-Hegglin anomaly
Due to increased splenic sequestration "Big spleen" syndrome: hypersplenism Due to dilution of blood Multiple transfusions
Due to multiple reasons Open-heart surgery Thrombocytosis Reactive (transient) thrombocytosis Myeloproliferative disorders QUALITATIVE PLATELET DISORDERS Important lab tests for qualitative platelet disorders: Platelet count Normal PT Normal APTT Normal Template BT Normal or abnormal Hereditary qualitative platelet disorders Due to disordered platelet adhesion Bernard-Soulier (giant platelet) Syndrome von Willebrand Disease (vWD) Hypergammaglobulinemia DISORDERS OF SECONDARY HEMOSTASIS HEREDITARY DISORDERS OF SECONDARY HEMOSTASIS AUTOSOMAL DOMINANT von Willebrand disease (vWD) X-LINKED RECESSIVE Factor VIII deficiency (hemophilia A) Factor IX deficiency (hemophilia B) AUTOSOMAL RECESSIVE Factor deficiencies Factor II (prothrombin) deficiency Factor V deficiency Factor VII deficiency Factor X deficiency Factor XI deficiency Factor XIII deficiency Factor XII deficiency PK deficiency HK deficiency Of factor I (fibrinogen) Afibrinogenemia Hypofibrinogenemia Dysfibrinogenemia ACQUIRED DISORDERS OF SECONDARY HEMOSTASIS Disseminated Intravascular Coagulation (DIC) Liver disease (LD) Hemorrhagic disease of the newborn (HDN) Acquired inhibitors (circulating anticoagulants) Thrombotic Disorders
Prothrombin Time and Activated Partial Thromboplastin Time in Pregnant Women Attending Antenatal Clinic at Nnamdi Azikiwe University Teaching Hospital (Nauth), Nnewi, Nigeria - A Cohort Study