Discovering

Collagen
The most complete reference
booklet about collagen!
NEW!
Genacol®
Instant
More details inside
PAGES 10 - 11

Think collagen, think Genacol®!

Collagen
can help:
Joint pain,
Fibromyalgia,
Wrinkles
and more
INDEX
Collagen, the glue of life!................................................................................ 2

How the body rebuilds itself .......................................................................... 3

Why is collagen necessary for youth and health? ........................................... 4

Cartilage
Collagen and sleep............................................................................................ 5

Diseases due to collagen deficiency............................................................. 6, 7

Collagen and skin.............................................................................................. 8

Genacol®! A new discovery........................................................................... 9

NEW! Genacol® Instant - Instant relief!.....................................................10

Genacol® - Clinical Trials ................................................................. 12, 13, 14

Dr. Price’s Study

Dr. Sal Martingano’s comments ...................................................................... 13

History of Genacol® ..................................................................................... 15

Testimonials .................................................................. 11, 16, 17, 18, 19, 20, 21

Frequently asked questions about Genacol® .................................. 22, 23, 24

Bibliography................................................................................................... 25
Dear Readers,

This reference booklet was produced in order to answer your

questions about collagen. You will find a lot of information
on collagen and its properties. Included as well, are clear
and simple explanations about problems related to collagen
deficiency. You’ll understand why Genacol® can bring you
the help that you are looking for.

Genacol® is the result of more than 20 years of research.

Thanks to a unique and exclusive process called AminoLock®
Sequence Technology discovered by the DirectLab Inc.
Research and Development Division, Genacol® is the only
100% pure collagen product that has this concentration of
amino acids.

This booklet contains important information about collagen

and will clearly explain both the difference and superiority
of Genacol® as compared to other collagen products.

Enjoy your reading!

A. Prud’Homme, n.d.
Vice-President
International Sales

1
 Collagen, the glue of life!
Collagen is present in all multi-cellular
organisms. It is the fibrous structural protein
that makes up the white fibers (collagen
fibers) of skin, tendons, bones, cartilage,
and all other connective tissues. It also
provides structure throughout the gelatinous
substances of the body, such as in the vitreous
humor of the eye. In other words, collagen is
a natural protein that makes up most of the
body’s structural support and is the primary
Normal collagen fibers
substance of connective tissue. It is this
fibrous connective tissue that holds our
body together.

Collagen gives to different organs and tissues

their strength and elasticity. Collagen makes
up 25% of the dry protein weight in the
human body. About 75% of our skin is made
of it, and overall, some 30% of our entire
body is collagen. Collagen is part of the natural
makeup of our tendons, ligaments, joints,
muscles, hair, skin, and vital organs. When Arthritic collagen fibers
the body’s essential supply of collagen is
reduced, the body is affected. Weakness,
fatigue, aches, pain, and an overall lack
of energy are frequent symptoms of the
problem – symptoms that only increase as
we get older.

In addition to its many structural properties,

collagen serves as a major catalyst for the
growth and repair of nearly all of the body’s
tissues. Many different aging and collagen
disorders are related to a deficiency of this
vital protein.

Collagen molecule

2
How the body rebuilds itself
Whether the body can efficiently
rebuild and repair itself is dependent
upon its ability to convert one body
resource into another. This process
of protein synthesis is a metabolic
process requiring collagen as a
catalyst. As collagen diminishes in
the body, both the resource and the
catalyst are reduced.
Many factors can harm and reduce
our body’s collagen production.
Smoking, drinking alcohol on a regular
basis, coffee, intensive stress and
excessive physical training are some
of the factors responsible. Also,
infections, pollution and bad climatic
conditions as well as medication and
drugs weaken our organism.
Those of us who wish to look and
feel younger should be interested in
collagen synthesis. Therefore, any
food supplement that can enhance
the rebuilding or healing process of
our body is something that we should
strongly consider.
Producers of health food supplements
have consistently recognized the
need for collagen supplements. The
body manufactures its own collagen
every single day, but since production
diminishes with age, the available
supply of collagen quickly becomes
less than enough. Deterioration of
various body parts gradually follows.
The first signs are wrinkles and the
beginning of unexplained joint pain.
This is only part of the effects. As
health begins within the body, the
secret to a young and healthy
appearance is to act on the cause of
the deterioration before it takes hold.
The tendons of our body
act like rubber bands.
These fibers are made
up in large part of
collagen. To maintain
elasticity and flexibility,
our tendons require a
large amount of
collagen, especially
after an injury or
because of the natural
aging process.
3
 Why is collagen necessary for youth and health?
Collagen is naturally produced by the
body. It is vital to the body’s functioning
because it is the tie that binds! The
body’s use of collagen cannot be
overstated. It makes up the body’s
joints, muscles, hair, skin, tendons,
and ligaments. It provides structure
to our body and forms the molecular
cables that strengthen the tendons.
Collagen makes up the vast resilient
sheets that support our skin and
internal organs. Bones and teeth are
formed when the body adds minerals
Collagen, looking to collagen.
for the fountain
of youth Collagen fibers are woven together
like pieces of fabric to form a network
in which new cells grow and reproduce.
Any time the body needs to build
new cells, such as in the healing or
growing process, collagen plays a
central role. Collagen is the substance
that protects and supports the softer
tissue of the body, and it is what
connects them to our skeleton. In
other words, collagen is both the
material and the glue that holds our
body together.
4
COLLAGEN AND AGING
The body’s production of collagen
slows with aging. Things we have
always done, like running or jumping,
suddenly seem more painful. Injuries
that have never proven serious
before begin to hurt us. Joint pain
becomes more problematic. With
continued aging, our connective and
muscle tissues break down due to an
increase in collagen deficiency and
damage. As a result, we experience
a weakening of our skeletal structure.
We start to feel the pain of aging. So,
what should we do to nourish our joints?
Outside the body, the slowing of the
skin’s production of collagen becomes
increasingly more pronounced. The
skin starts to wrinkle. It loses its
youthful glow. The appearance of
healthful radiance vanishes. Soon
we develop ridges and furrows, red
marks and brown spots. Our skin
loses elasticity and moisture.
Cartilage
Cartilage is a rather firm rubber
material that covers the extremities
of bones in normal joints. The primary
function of cartilage is to reduce joint
friction and, since cartilage can change
shape when compressed, serve as a
shock absorber for the bones.
Collagen is a key component of
cartilage (67%), providing it with its
strength. When the body’s collagen
production is reduced, cartilage
production is affected and so are all
the body’s systems that contain
cartilage. Cartilage can change
shape because it is composed of
over 70% of water, which can be
redistributed with compression or
movement. Since cartilage does not
contain nerves, in the beginning, you
never feel pain when these changes
occur. As we age, this shock absorbing
quality is reduced due to collagen
deficiency which is why activities like
running and jumping feel less com-
fortable as we get older.
Collagen and sleep
The vast majority of collagen’s catalytic
work is best conducted by the body
at night during sleep. Sleep is not an
interruption of activity but simply
another form of activity. It is indispen-
sable for healing.
Research has proved that a large
part of the essential metabolic work
in the repair of the body takes place
when we sleep. Sleep is divided into
several phases. Our body regenerates
during phase 2 and 3; however, it
regenerates the most during the first
phase called the Alpha phase. In
other words, during the Alpha phase
our body uses its full regenerative
capacity. During the Alpha phase,
our system looks for available amino
acids and nutrients in order to trans-
form them into essential elements for
our body. The sleep cycle repeats
itself several times over many hours.
The ability to convert collagen into
bio-digestible elements takes place
while we sleep. So, in order to develop
muscles, tendons, ligaments and to
rebuild and repair organs and skin,
the body must go through a process
of protein synthesis that happens
specifically during the Alpha phase.
One thing is for sure, sleep is really
important and essential for good health!
5
 Diseases due
to collagen deficiency
Diseases due to collagen deficiency, long associated
with aging, are not only found in the elderly. They
form an entire group of diseases that involve
abnormalities of the immune system. The blood
plasma of patients with disease due to collagen
deficiency show significant levels of auto-antibodies.
This antigen-antibody reaction leads to inflammation
of many of the body’s vital tissues. Here is a brief
description of some of these diseases and a list of
some auto-immune diseases:
Arthritis
Arthritis is a general term describing inflammation
of the joints. The most known form of arthritis is
osteoarthritis, which is also called degenerative
joint disease. Osteoarthritis is associated with a
breakdown of cartilage in joints and most commonly
occurs in the hips, knees, shoulders and spine. It
can dramatically affect the fingers and toes.
All arthritis sufferers share common symptoms of
severe pain and loss of movement in both range
and motion, all of which cause premature aging
and lead to a diminished quality of life. Research
has demonstrated that when people suffer from
arthritis, a selective destruction of collagen in the
joint cartilage has occurred. White blood cells
attack the joint cartilage, which in turn activates the
immune system to develop antibodies. These
antibodies turn around and attack what they
perceive to now be the enemy, i.e. ‘’collagen’’.
Consequently, the immune system’s response is to
attack all the cartilage that is degenerating in the
body. So, even if there may only be a problem in
one wrist or knee, both wrists hurt, both knees hurt,
our back, our hips, and both shoulders feel the
pain. In the end, the result is the same: age-related
pain increases along with a pronounced loss in
quality of life.
Rheumatic disease is a frequently-used term,
since rheumatoid arthritis, the most common of all
diseases, displays many characteristics of this
group. The cost of traditional arthritis treatment
6
has skyrocketed from $65 billion in 1992 to nearly
$480 billion in 2002. Most of the cost went to
disability payments and lost time at work. The
effects of arthritis result in 20,000 deaths as well as
2 million hospitalizations each and every year.
Furthermore, there is an additional horrific cost of
treating the side effects of arthritis medications,
including corticosteroid drugs and immune sup-
pressive drugs. Without a doubt, collagen-related
diseases represent a terrible burden on society.
With 60 million Americans suffering from arthritis,
we can say that there is an arthritis epidemic. John
Klippel, Medical Director of the Arthritis Foundation,
flatly stated: this should be a wake up call. We’ve
always thought the problem was greater than
expected. Studies and testimonies have demonstrat-
ed that a hydrolysate of collagen such as Genacol®
is one of the most effective solutions.
Fibromyalgia and collagen
The acceptance of fibromyalgia as a disease and
its definitive diagnosis has been hampered by a
lack of knowledge concerning the underlying
physiopathology of this disease and the lack
of specific biochemical markers applicable to
its diagnosis.
Research has shown that fibromyalgia patients
(diagnosis made by the American College of
Rheumatology) had a lower amount of intramuscular
collagen and lower levels of collagen metabolites
(urine and serum). This may lower the threshold for
muscle micro-injury and contribute to the remodeling
of the extra-cellular matrix and collagen deposit
around the nerve fibers, as well as contribute to the
lower pain threshold at the tender points.
The average complaint level of pain in people who
have had medically diagnosed fibromyalgia for
2-15 years and are taking a "collagen hydrolysate"
decreased significantly in an overall group average,
and, in some individuals, quite dramatically. In our
opinion, patients with fibromyalgia may improve
symptomatically their chronic pain by taking "collagen
hydrolysate" such as Genacol®.
Bursitis, tendonitis and tendinosis
Bursitis is caused by arthritis inflammation or by
infection. The joint areas most commonly affected
are the shoulders, elbows, wrists, hips, back,
and ankles, etc.
Individuals with bursitis have pain, tenderness
and stiffness near the affected area. Local muscle
weakness frequently develops as a result of
avoiding painful joint movements, such as those
caused by climbing stairs.
Tendinotis, an inflammation of the tendons, has
frequently been considered the cause of tendon
pain and the associated loss of strength and
movement. More recently, researchers have
discovered that most people diagnosed with this
disease have no sign of tendon inflammation.
Consequently, medical science has come to see
tendonitis more properly classified as tendinosis.
Nowadays, the terms are interchangeable.
Tendinosis/Tendonitis is caused by a breakdown
of the collagen-composed tendon. Collagen
contributes to the rope-like structure of a tendon
and to its strength. When collagen breaks down,
small tears appear in the tendon, weakening it
and causing pain. It is especially wearing on
those who perform repetitious tasks in their
jobs, sports or daily activities.
Bursitis, tendonitis/tendinosis can be successfully
treated by letting the painful areas rest, applying
ice or taking a collagen supplement like Genacol®.
This gives the body time to repair and repro-
duce the damaged cartilage, provided that the
body is still producing the necessary amount
of collagen.
A few more exam-
ples of diseases
relating to collagen
deficiency
Here is a list of diseases
which DirectLab Inc has fre-
quently received eloquent
testimonies where a sig-
nificant decline of the symptoms and pain were
noticed after taking Genacol®: All arthritic types,
osteoarthritis, fibromyalgia, bursitis, tendonitis
or tendinosis, acute rheumatic fever, lupus
erythematosus, dermatomyositis, infectious
scleroderma, arthritis, polymyositis, ankylosing
spondylitis, etc. Here are more details about two
of these diseases:
-Systemic lupus erythematosus (SLE) is the
most common and serious type of lupus. With
SLE, the immune system that normally protects
the body from germs, viruses, and bacteria
begins to malfunction. It generates antibodies
that attack healthy tissue in different parts of the
body. These tissues become inflamed as a
result. Inflammation can occur in the skin, muscles,
joints, heart, lungs, kidneys, blood vessels and
the nervous system.
-The word scleroderma means 'hard skin.'
Scleroderma is a condition where the skin gets
thick and hard. Hydrolysate of collagen has
been given to people suffering from this disease
with good results. More research is needed to
prove that collagen can really help.
Some collagen diseases have no satisfactory
treatment, but most can be treated medically.
For example, rheumatoid arthritis is commonly
treated with aspirin-like compounds, corticosteroids
and immunosuppressive agents, used separately
or in combination. Some collagen diseases, like
rheumatic fever, are treated with antibiotics, but
unfortunately, in traditional medicine no treatment
gives complete satisfaction at the moment.
7
 Collagen and skin
At about twenty-five years of age, the body’s A few facts:
collagen production decreases in the skin. This
process accelerates between the ages of forty - Collagen makes up the majority of the derma.
and fifty. Many studies have shown that our
normal collagen production can diminish at a rate - Collagen is not found in food. It is made by the
of 1% per year after the age of forty which means fibroblasts of the body.
that, by the age of fifty-five, the body has lost
approximately 15% of its capacity to produce - Collagen is the structure, the molecule that
collagen. By the age of seventy, the loss of collagen holds our body together.
production can diminish by 30%.
- Collagen is the most abundant protein in
When the production of collagen slows down, the the body.
skin retains less water, gets thinner and begins
to wrinkle. - Our body is composed primarily of connective
tissues and collagen makes up 85 % of all
The lack of collagen in the skin becomes apparent connective tissues.
with thinner skin. Little by little, capillary tissues
of the skin become thicker, which reduces the - Collagen is the protein that supports our skin.
capacity of the skin to retain nutrients and water.
The skin then presents a bigger risk of developing Due to its composition, collagen is the most
wrinkles, stretch marks and infections. Its color complex protein of the connective tissues of the
and pigmentation change, and brown spots human body.
appear. Since the skin is less healthy, its capacity
to serve as barrier to bacteria and viruses is
reduced. A supplement of collagen can largely
help to regenerate skin tissues and so helps to
slow down the aging process, particularly if it is
ingested, since the effect will occur throughout the
whole body.

8
Genacol®! A new discovery
Genacol® is a hydrolysate of collagen,
generated by an enzymatic process
and re-modulation of amino/peptides.
This exclusive process is called
AminoLock® Sequence Technology.
DirectLab Inc. produces a very high
quality collagen product, in 400 mg
capsules, without any preservative
or fillers. No other collagen product
on the market possesses the same
concentration of amino acids as
found in Genacol®.
The unique manufacturing process
called AminoLock® Sequence Tech-
nology is an exclusive approach
developed by the Research and
Development Division of DirectLab
Inc. and consists of enhancing collagen
amino/peptides. Genacol® is manu-
factured under the highest biotech-
nological standards and conforms to
government requirements.
A collagen matrix is a safe, formulated
substance that stimulates the pro-
duction of many different kinds of
collagen in the body. The collagen
matrix, formulated from pure collagen,
produces incredible results in the
human body when used on a regular
basis. Genacol® is a protein complex
that uses specific AminoLock®
Sequence Technology. No other
product on the market contains this
concentration. In order to obtain this
concentration of amino acids, it
would be necessary to have up to
10 times more collagen.

AminoLock® Sequence Technology

exclusive to Genacol ®

PRINCIPAL TYPES OF COLLAGEN

Genacol is a collagen matrix that can help stimulate the production of the principal types of
®

collagen which make up 99% of all collagen found in the body.

They are present in the body in the following way:
Type I - Bones, tendons, ligaments and skin;
Type II - Cartilage and structure of the eyes;
Type III - Liver, lungs and arteries;
Type IV - Kidneys and many other internal organs;
Type V - Cells surfaces, hair and placenta.
Genacol® is the only product that has this special amino acid combination.

Example of a typical collagen sequence 9

 Genacol® Instant - Instant relief!
This high quality product is a topical gel
with added Genacol® microbeads designed
to relieve local muscular, rheumatic and
arthritic pains. These microbeads are
essential and in large part, responsible for
the excellent results of the product. Here is
why:

Due to the bio activity of collagen, our

laboratory concentrated on developing a
new technology able to adequately isolate
Genacol® in order to maximize its bio activity
when applied. We reached our goal by
inserting Genacol® into the microbeads.

By gently rubbing the painful area with

Genacol® Instant, the microbeads
release the collagen, immediately activating
and rapidly relieving muscular, rheumatic
and arthritic pains.

Furthermore, when the mild wintergreen smell

quickly fades away, Genacol® Instant
relieves not only your pain but leaves your
skin feeling soft and smooth.

The soothing effect of Genacol® Instant

will allow you to pursue your daily activities,
enjoyably and pain free.

Genacol® and Genacol® Instant are

After more than two years of development, both available in all pharmacies and health
DirectLab inc. is proud to present their new food stores.
product, Genacol® Instant.

INSTANT RELIEF!
10
Testimony
About a month ago, I injured myself when I fell off my leg exerciser,
which is located near my washing machine.

Being a heavy person, I tired to avoid falling off by shifting all my

weight to my left wrist. This had a devastating effect on my entire side
and neck. I then felt intense burning and a numbing sensation for
several minutes all the way down to my feet. After the numbness
stopped, the pain and inflammation remained intense. Furthermore, I
hurt my leg because when I fell, my thigh hit the exerciser which
caused a huge bump on my leg. I then went to my doctor who examined
me and prescribed anti-inflammatory drugs and painkillers. After using
these products for several days without any conclusive results, a friend
of mine talked to me about this new product called Genacol® Instant.
On top of being a natural product, it is supposedly very effective. So I
decided to try the product. After using the product for a few days and
by applying it 4 times a day, the inflammation disappeared and the pain
also diminished by 85% which allowed me to go on normally with my
daily activities. As for the bump on my leg, it quickly disappeared and
instead of becoming all shades of colour, the bump went from blue to
the normal skin colour. With each application I felt a light freshness
and afterwards the pain would disappear instantly.

I had to go a few days without the product and that quickly made me
realized how much it was helping me! Thanks to Genacol® Instant I can
sleep comfortably and without any pain. Otherwise, my neck would hurt
all night and would prevent me from getting a good night’s sleep.

Genacol® Instant is truly responsible for my rapid healing and I recommend

it to everyone.

Thanks a million!!

Mrs. Éliane Bossé,

Montréal, QC

Genacol® Instant microbeads

relieve muscular, rheumatic
and arthritic pain.

11
 Genacol® - Clinical Trials
COLLAGEN PRODUCTS ARE NOT
ALL THE SAME.
Not all collagen products are the
same. Of the very few collagen
products, most have a very low
absorption rate, something in the
neighbourhood of 20%.
Dr. Stephen Ho, Genacol® is the best of these products,
M.D. because it is, first of all, a collagen
matrix. It stimulates production of the
various types of collagen rather than
just one of the fourteen kinds.
Genacol® Genacol® is produced from pure
collagen through a complex formulation
is the best of process carried out in Canada as a
all products result of a partnership between
because it is DirectLab Inc. and a biotechnological
laboratory. The end product is Genacol®,
a collagen which has been demonstrated to
matrix. have a very high bio-availability.
In a very significant three-month
study aimed at comparing Genacol®
with a liquid collagen as well as an
over-the-counter collagen supplement,
Dr. Stephen Ho, a well known trauma
physician, evaluated the results using
five groups of test subjects. Each
group consisted of 30 subjects, all
similar in size, weight, health condition,
age, and gender. The first group was
given Genacol® over a 90-day period;
the second group took liquid collagen;
the third group received a common
collagen supplement; the fourth group
was given a placebo composed of
neutral ingredients; and the fifth
group (the control group) was given
nothing at all.
A physical history was taken before
and after the 90-day study to compare
12
the groups. The Genacol® group
obtained the best results, followed
by the liquid collagen, the collagen
supplement, the placebo, and then
the control group. The study was
independent, and Dr. Ho was not
paid by any commercial entity for
conducting it. Table 1 summarizes
the results. (See reference on page 13)
The Genacol® group recorded a
considerable reduction of aches
and pains. This group also recorded
feeling much younger and stronger.
The liquid collagen group, using a
Type II collagen in liquid form,
demonstrated favourable improve-
ments, but nearly 30% less than
the Genacol® group. Genacol® is the
best of all products because it is a
collagen matrix.
Group III, which was administered an
over-the-counter collagen supplement,
showed only nominal improvement.
It obtained the same results as the
placebo group. The placebo group,
Group IV received only a non-bioactive
capsule. There were minor improve-
ments recorded, most of which can
be attributed to psychological factors,
given that they expected results.
This group was unaware that it was
not being given any collagen. The
Control group, Group V was given
neither Type II collagen nor a placebo.
In composition, age, gender, and
state of health, the members were
similar to Groups I through IV.
Histories were taken at the beginning
of the study and at the end. No
changes were observed.
Dr. Ho’s conclusion was that the Genacol® brand
collagen matrix in its pure, dry-state form was
far superior to that of the liquid or the
over-the-counter collagen supplement. He also
concluded that Genacol®, taken on a regular
basis, resulted in a more youthful appearance
and feeling. Pain was significantly reduced. He
also stated that the group taking Genacol®
reported a more restful and longer sleep period,
as well as more energy during waking hours.

Table 1
Comparison Study of collagen matrix and Type II collagen
Summary
Group I Group II Group III Groupe IV Group V
Genacol® Liquid Collagen Placebo Control
Collagen Supplement Group
Reduction in
aches and Considerable Favourable Some Some None
pains
Noticeable
change in Considerable Favourable Very little None None
skin
Noticeable
feelings of Considerable Favourable Very little Small None
renewed
energy

Dr. Price’s Study

Dr. Patrick Price, a Houston health professional, conducted another major independent study on
Genacol®, which used three groups of patients that were essentially identical in makeup. Dr. Price
found that Genacol® produced highly-observable improvement in energy, arthritic and injury pain
relief, as well as skin texture. A placebo group had only minor improvements, and the control group,
like the one in Dr. Ho’s study, remained the same.

Dr. Sal Martingano’s comments

There are many types of collagen that make up most of the body’s skin, tendons, bones, cartilage,
and other connective tissue. Although naturally produced by the body, collagen production declines
after the age of 25. Degenerative collagen diseases associated with aging affect the entire body.
Collagen diseases include arthritis, fibromyalgia, bursitis, tendonitis, and other related conditions.
Wrinkling, liver spots and joint pain are symptoms of degenerating collagen. Recently, new collagen
products that help with collagen diseases have appeared on the market. These tend to be Type II
collagen, collagen matrix, and collagen-derived products such as glucosamine-chondroitin. Of the
three, the collagen matrix has been found to be the most effective. The recommended form of
collagen matrix is Genacol®. This product is far more bioactive than other products that have been
clinically tested.

13
 Genacol® - Clinical Trials (continued)
Although more clinical research is required in cartilaginous tissue of the treated patients in
order to determine the effectiveness of the various comparison with the patients from the control
food supplements, numerous studies have group. These results lead to believe that the
already revealed the beneficial effects of certain collagen hydrolysate reaches the tissues and
nutrients on joint health. Collagen hydrolysate can cumulate in the long term.
proves to be up to now, one of the most promising
food supplements. Collagen is the most abundant The next step of the trial consisted in determining
protein in the system. It structures tendons, if collagen hydrolysate could have a positive
influence on the joint tissue after its accumulation.
cartilaginous tissues, bones and connective tissues.
The composition of collagen hydrolysate of That positive influence had to translate in
animal origin is similar to the collagen found in two effects: inhibition of the deterioration of
human cartilage. the supporting joint tissue
and/or stimulation of new
Why does collagen hy- cartilaginous cells, aiming to
drolysate contribute to compensate for the naturally
Collagen hydrolysate
the treatment of osteo- damaged tissues. Thanks to
arthritis? has proved to be a benchmark cellular culture,
up to now, one of researchers were able to
Research leads to believe the most promising demonstrate that the pre-
that collagen hydrolysate sence of collagen hydrolysate
can stimulate the synthesis food supplements. stimulated collagen produc-
of collagen, which plays tion. However, natural colla-
an important role in gen would not exert that
maintaining healthy joints. stimulating effect.
During the convention, Steffen Oesser Ph. D,
who is part of the General and Thoracic Surgery Furthermore, researchers stimulated the supporting
Department at the University of Kiel in Germany, joint tissue in order to assure their reproduction
presented a resume of study results on collagen in the presence of collagen hydrolysate, dimini-
hydrolysate. In order to determine if collagen shing the degenerative impairing of the joint
hydrolysate can effectively reach the joint tissue. “These results are of certain importance.
tissues and modify them, researchers of They allow us to understand that collagen
the University of Kiel studied the absorption hydrolysate reaches not only the aimed joint
rate and the accumulation level of collagen tissue but its presence can also positively trans-
hydrolysate by controlling its absorption in the form the joint”, added the Dr Oesser.
human organism. According to the results of
that study, the rapid absorption of the collagen Reference: PR Newswire on behalf of GELITA
hydrolysate in the gastrointestinal tract doubled Health Initiative
the quantity of nutrients accumulated in the www.gelita-health-initiative.com/en

AminoLock®
Sequence Technology
exclusive by Genacol ®
14
History of Genacol®
In the mid 90’s, a research and development
company located north of Montreal,
Quebec, discovered collagen’s properties
as a dietary supplement. These researchers
developed various formulas in collaboration
with laboratories with very high technological
standards of manufacturing. These formulas
were quickly appreciated by the natural
health community.

M. Guy Michaud
President of DirectLab Inc.

Over several years, this product was

distributed successfully in various ways.
Under Mr. Guy Michaud’s presidency, in
October 2000, a new laboratory, DirectLab
Inc. was created and Genacol® made
its market debut. DirectLab Inc. is now
a biotechnological laboratory that uses
a unique process called AminoLock®
Sequence Technology. This concept is
now one of the best available.

15
 Testimonials
DirectLab has collected numerous testimonies sent regularly by satisfied
Genacol® users

A year and a half ago, during a wrestling match, I seriously

injured my left shoulder: tears in the ligaments and tendons
of the shoulder. I really thought that it was the end of
my career. Doctors prescribed anti-inflammatory drugs
but they didn’t work. The pain persisted. One day, one of
my students suggested I try Genacol® but I was sceptical.
Since I was continuing to train and as my injury was still
hurting a lot, I finally decided to take Genacol®.
At the end of the first month, I already had very good
results. Before beginning Genacol®, my shoulder worked only at 25%.
After two months of Genacol®, my shoulder has improved to 80%!!! I
learned that Genacol® helps to rebuild tissues, I know now that it’s true
because I am living proof!! I had excellent results with Genacol® and I
confirm that it is a wonderful product! I want to suggest to all athletes
who have joint, tendon or muscular pain to use Genacol®. I use my body to
wrestle and Genacol® helps my body to wrestle!!!!
Congratulations and thanks to Genacol®!
Jacques Rougeau,
Professional wrestler

I’m pleased to tell you that my wife Marjorie definitely feels that the
Genacol® program is good for her. She was recently advised to undergo
knee replacement surgery, having almost no cartilage left. We have no
Medicare plan and, as you know, the cost of knee replacements is pretty
high. We saw your ad in a national magazine and decided to contact you.
Marjorie has been taking Genacol® for over a month. She used to
complain constantly about feeling tired and lacking energy. Now, she
feels that Genacol® is doing the trick: she walks better and uses her
crutch less and less. Let’s see what happens later on, but it’s already a
major improvement. She will continue taking Genacol® and will have
another X-ray done in six months. For now, surgery is no longer an alter-
native, but Genacol® is. Thanks again and I will keep you posted on the
evolution of her condition on a regular basis.
Kind regards,
Grant Cooper, Port Elizabeth, South Africa
16
 After a great career in the National Hockey League,
I was suffering from multiple injuries. Two years ago,
I heard about Genacol®. I was really sceptical about
the effectiveness of all these natural products. In
spite of this fact, I started to take it. I felt the
difference right away. Since I had a knee injury which
required surgery, Genacol® helped me to go on with all
my activities without too much pain. Recently, I
finally had my surgery and I have to say that Genacol® allowed me to recover
in the most encouraging way! So, I am now a spokesman for Genacol® and I talk
about it to a lot of people. It’s still a pleasure to hear about those people who
come back and thank me for advising them about this great product! Also, my
spouse is no longer suffering from a painful arm tendonitis.

I am truly encouraging everybody who’s suffering from arthritis or joint pain

to use this great Canadian product, Genacol®.
Thanks Genacol®!!!

Yvan Cournoyer, #12

Montreal Canadian Ambassador

I originally purchased Genacol® because I have very thin hair and wanted it
to thicken, which is what happened. It’s great. But something else also
happened: now, when I get up in the morning and walk down the stairs, my
knees are a lot more flexible and don’t creak any more. It’s a lovely surprise!

Rene Arnold

Being on the Pro-Celebrity Golf Circuit and always a fitness enthusiast, I felt
I had done irreversible damage to my knees. When I was first approached
about Pure-Col*, I was sceptical, but willing to give anything a try. I tried the
product for 6 months. When I stopped taking it, the pain returned. Now, I
would not do without Pure-Col*! This is a revolutionary product, and, as a
bonus I look and feel younger.
John Miles, musician and artist, UK

*Genacol® is distributed under the name ”Pure-Col” in the UK

17
 Dear Sir/Madam,

My wife is 75 years old, and I am 79 years old. Both of us were suffering

from arthritis pain. Only one week after taking your miracle "Collagen
Exclusive Matrix" supplement, at the dosage recommended on your bottle,
our quality of life has improved tremendously.

I highly recommend your product to anyone whom can use it for its intended
purpose. Your product caught my eye, on your display unit, conspicuously
placed at the front counter of our local Pharmacy. At first I thought it was
kind of expensive, but then after trying your product, I concluded that it was
money well spent. It most certainly performed as advertised.

May I take this opportunity to congratulate your Company for introducing

such an excellent product?

Regards,
V. Pucci

I am a retired 62 year old. For the past two years I’ve suffered from
tendonitis in my left knee, which restricted my physical activities. Cycling,
walking and training became, for someone very active, completely impossible.
I tried chiropractors, many cortisone injections, and even the services of an
orthotherapeutic practitioner. Despite all these treatments, my pain
continued and even became worse. I was considering knee surgery when
a friend suggested I try Genacol®. I had nothing to lose. I started at 5
capsules a night for the first week, and then reduced to 4 capsules for the
following weeks. To my great satisfaction, I was able to see an improvement
in 12 days. I am now on my second bottle. I take 3 capsules at night before
bedtime and I let Genacol® do its work. My knee no longer hurts, I’ve
started gardening and cycling again, which in itself is a great improvement,
and I’ve lost 5 pounds. I feel so much better!

Thank you Genacol®. Thank you also to my friend for recommending this
wonderful, completely natural product.

Hélène Benoît, Gatineau

18
I have been afflicted by fibromyalgia for more than eleven years. This
diagnosis was confirmed by an experienced rheumatologist. For a long time,
the pain restricted my quality of life. Without any strength in my legs, I
had to resign myself to using a wheelchair. I started to take Genacol®, 6
capsules each day, and 3 weeks after, results are there! My sleep is better,
my pain which I lived with 24 hours a day, diminished a lot! I am now able
to take a little walk and I feel really happy!
Thank you Genacol®!!
Benoit Cyr, Québec

Being a high-level athlete for many years,

I often have to deal with injuries. For
several months, I had to endure awful
sciatic pain. Given my allergy to anti-
inflammatory drugs, I didn’t know what
to do anymore. One day, someone told me
about Genacol®, a product that could
surely help me. A few months before the
World Championship, I had nothing to
lose, so I decided to try this natural product. To my big surprise, the pain lessened
and I rediscovered the flexibility that I had lost. I kept on taking Genacol® and the
pain completely disappeared. I came back from the World Championship injury-free
and with two medals! With Genacol®, I am a sure winner!

Marie-Hélène Leboeuf, 24-year old, World Champion W.K.A.

2003-2005 Karate

I had been suffering from acute tendonitis (tennis elbow) for over a year. Anti-
inflammatory drugs had bad side effects for me. Cortisone injections were painful
and not very helpful in the long run. I was taking ibuprofen every single day to help
ease the intense pain. I started taking Genacol® on January 26, 2007. For 2 weeks
I took 6 capsules a day, following the recommendation of a friend who had taken
this supplement. I then reduced the dosage to 3 capsules a day. Here we are,
February 22, 2007, and I am no longer in need of any type of pain reliever, indeed,
I haven’t been taking anything for the pain for about 2 weeks. I am convinced that
Genacol® is the reason why. I have added no other supplement to my diet except
Genacol®. I plan on continuing to take this wonderful collagen supplement, and will
let you know how I am doing with long term use of Genacol®.
Thanks Genacol®, for giving me back the use of my arm!
Christine Lockett, Blainville, Québec

19
 I had problems with the mobility of one arm and one leg as well as problems
with my back, my cartilage and my tendons. Following a problem in my spinal
column, I had surgery that was, thank God, successful. After the surgery I
was prescribed anti-inflammatory drugs, which I had no interest in taking. My
son had me try Genacol® and seeing the beneficial results that he had with
this product, I decided to follow the treatment for 6 months. After this
period, I have had an improvement of 90% in the mobility of my leg and my
shoulder problems have also disappeared. Conscientious of the well being of
people, I counselled a few doctors on my experience. They have followed the
treatment and are now prescribing it to their patients.
Thank you Genacol®
Mr. Raymond Touret, businessman
Fort-de-France, Martinique

I have been diabetic for more than 25 years, and must give myself many insulin
injections a day. When you are diabetic, it is strongly recommended to exercise.
However, I could not exercise because I had very painful knees. Taking Genacol®
has changed my life! Working as a construction contractor, walking on site to
supervise the work had become very difficult. But with Genacol® the aches and
pains in my knees have disappeared and I no longer have difficulty walking or
climbing stairs. The fact that I can now exercise, on the advice of my doctor, I
have been able to reduce my insulin injections by 40 %. When you are diabetic,
doctors tell you to keep away from natural products so you don’t dare try some-
thing natural. Now I am convinced that, thanks to Genacol®, I have a new life!

Yvon Deschesnes, Mirabel, Qc.

Contractor thanks to new and healthy life!

For several years I have been suffering from arthritis pain, sore back,
muscle cramping, pain in my fingers, knees, bones, joints, etc. I am 56
years old, work as an office technician and an activity coordinator for
senior citizens. I have many social activities. I did research on Internet
to try to find something that would help ease my many aches and pains.
I do not believe in taking products like Vioxx or other medication of that
nature. I found Genacol®, I tried it, and I can tell you that after only 4
days I started to feel the benefits in my joints. I tell my friends that
Genacol® is truly miraculous. I certify that Genacol® is a real miracle! I
told my doctor about and also told him that my aches and pains have
diminished by 80 % after only 3 weeks of using Genacol®. I continue to
take Genacol® because I can now exercise and continue to do my work
without any pain.
Yours Truly, Jacqueline Vézina, Rivière-au-Renard, QC
20
February 8, 2006

I wanted to let you know that this is a fantastic product. I purchased

this product for my mother who is 71 years old. She really suffers from
fibromyalgia and arthritis and severe leg cramps every night. She has
been on your product now for about 3 weeks and she thinks it is a miracle
in a bottle. She has not experienced one single leg cramp and her movement
is fantastic! She feels wonderful and I am so happy for her because I
have seen her suffer for years. I personally have been on this product
for about the same amount of time and I have noticed skin changes and
great bowel movements.

Thank you for a wonderful product!

I have told lots of people about this great thing!
Tammy

Quelle merveille!

I have been taking Genacol® for 50 days now - my knee is so much better
(I injured it 2 years ago). The pain is almost gone and my range of motion
is so much improved. You can count on me for a testimonial – eh oui,
même en français. Vraiment, je suis épatée.

Merci,

Sabine Davies

Hello,

I just wanted to let people know that I have started using Genacol® and
in only one week I have noticed the difference in my skin and pain in my
bones. I have Lupus and also have skin cancer and since I have been taking
this product I noticed my bone pain is not as bad as usual and my skin is
starting to smooth in only one week. I cannot imagine what I will feel like
in a few months! I am getting this product for my mother and my sisters
as this is amazing I will not stop using this, just give it a try!! You will not
be unhappy I can tell you.

Shelley Craig
Toronto, ON

21
 Frequently Asked Questions about Genacol®
What is the difference between collagen and
glucosamine?
Collagen makes up 67% of cartilage as opposed to
only 1% of glucosamine. Glucosamine is an amino
sugar whereas collagen is a molecule containing
amino acids. Glucosamine is only found in large
quantities in the liquid of the synovial membrane.
Collagen is also found in the synovial membrane
but in larger quantities since it is the most abundant
structural protein in the body. Glucosamine acts
more like a lubricant in the joints while collagen
contributes to the global regeneration of the joint at
all levels: tendons, ligaments, cartilage, muscles,
membranes and the synovial liquid.
What’s the difference between Genacol® and
other products such as those containing Type II
collagen?
Genacol® is a matrix created by a procedure called
AminoLock® Sequence Technology developed
by DirectLab Inc. This matrix is produced from a
complex containing many types of collagen, thus
making it a far more complete product than the
ones using only Type II collagen. See reference on
page 9.
Why is it suggested taking Genacol® at bedtime?
It is suggested taking Genacol® at bedtime, because
during the Alpha phase which takes place during the
first 90 minutes of sleep, the body searches for the
nutrients necessary to repair itself. The essential
nutrients contained in Genacol® (amino acids) will
be used by the body at this precise time in an
optimal manner. Therefore, it’s better to take it at
bedtime. Even though it’s better to take Genacol® at
night, certain circumstances may make it impossible
to take it at that time. It would then be preferable to
take it in the morning, 30 minutes before breakfast.
See reference on page 5.
22
What is the ideal dosage?
If you drink about 1.5 liters of water per day
(please note that this quantity is the one recom-
mended for good health and not only for taking
Genacol®), you can begin with 3 capsules per day
at bedtime. If you are not used to drinking this
minimum quantity of water, start with 1 capsule per
day during the first week, increase the quantity of
water you drink and then you may go on to the
recommended dosage. After a few weeks of
treatment and in order to optimize the results, you
can double the dose to 6 capsules per day, i.e.,
3 at bedtime and 3 before breakfast. Caution: for
people taking medication, it would be preferable to
leave a 2 hour period between Genacol® and any
medication.
How long must I take Genacol®?
We suggest taking 3 capsules per day for the first
3 to 6 weeks and then progressively move to the
dosage that best suits you. In cases of degene-
rative diseases, in order to maintain the beneficial
effects and avoid recurring problems of pain and
discomfort, it is suggested taking Genacol® on a
permanent basis. Please note: According to an
internal survey, the majority of people had results
after only one bottle.
What other situations could Genacol® be used for?
Besides arthritis, osteoarthritis and fibromyalgia,
Genacol® can be used in cases of tendonitis, bursitis,
hernia, carpal tunnel syndrome and all other
auto-immune diseases as well as for aesthetic
purposes such as toning the skin and muscles.
Generally speaking, Genacol® can be used in
cases of joint and muscular pain, as well as to help
hydrate and tone the skin.
Who should take Genacol®?
Given that the body produces less collagen with
aging, every adult can benefit from Genacol®.
Can I take Genacol® if I am diabetic?
Contrary to glucosamine, Genacol® should not
affect the glucose level in your blood. Proteins do
not affect blood sugar levels. Since Genacol® is a
protein; you can safely use this product without
any fear with the approval of your health care
professional. Therefore people with diabetes can
benefit fully from Genacol®.
Can I take Genacol® if I have a fragile stomach?
Yes, there are no side effects from taking Genacol®
for people having a fragile stomach. In order to
facilitate digestion, you can remove the collagen
powder from the capsule and take it with some
water.
Is Genacol® absorbed by the body?
Yes, absolutely. The protein is micronised or
reduced to a fine powder which permits a more
effective absorption.
Are there certain health conditions for which it
is not recommended to take Genacol®?
Collagen products are generally recognized as
safe. However, if you are pregnant or breastfeeding,
there is not enough current information in regards
to the safe use of collagen. According to Health
Canada, the manufacturers of natural products are
not permitted to express an opinion on the subject.
We therefore recommend that you get a medical
opinion.
Can I take Genacol® with medicine or
supplements?
As far as we know, there is no medical interaction
with the use of Genacol®. Genacol® is a safe amino
acid complex and it is considered as a nutritional
supplement. Yet, we recommend you get a medical
opinion. As already mentioned, you should wait 2
hours before taking Genacol®, in order to minimize
the risk of interaction with each substance.
How many amino acids does Genacol® contain?
Genacol® contains all common amino acids in its
matrix, except for Tryptophan. Tryptophan is not
one of the amino acids found naturally in collagen.
Every capsule contains 400 mg. of our pure collagen
matrix without fillers, which makes Genacol® one of
the purest collagen supplements on the market.
What does “AminoLock® Sequence
Technology” mean?
We use a unique manufacturing process called
AminoLock® Sequence Technology, which in
turn generates an enzymatic process that recon-
figures the profile of amino acids. This exclusive
approach developed by our Research & Development
Division meets the highest nutraceutical standards,
creating a unique product promoting the five main
types of collagen and using a specific sequence of
amino acids. See reference on page 9.
23
 What is the source of the amino acids found
in Genacol®?

Genacol® is composed of hydrolyzed collagen

proteins which mean that they have been purified
with a unique enzymatic process. DirectLab Inc.,
through its AminoLock® Sequence Technology,
only uses certain fragments of bovine protein from
Germany (subcutaneous source, therefore there is
no contact with the animal’s blood or organs) that
have undergone strict and thorough analysis to
guarantee that the product is totally safe. No types
of mad cow disease (bovine spongiform ence-
phalopathy) or any other illnesses have ever been
detected from this source. The product is certified
by the Government of Canada and by Health
Canada among other agencies to meet the highest
nutraceutical standards.
Can I give Genacol® to my pet?
Please note:
These statements have not been
evaluated by Health Canada.
However, Genacol® conforms
to the requirements of Health
Canada This booklet has been
produced as a source of informa-
tion about collagen. The booklet
is not to be used as a diagnostic
tool, nor to treat, heal, or prevent
illness. Genacol® should be
considered as a basic nutritional
supplement. However, it is
recommended to seek advice
from your health care professional.

The good news is that you can give Genacol® to

your pet. Calculate one capsule per 40 pounds
daily. It is more effective to open the capsule and
give the powder in it to your pet between meals
(empty stomach). Place the powder on a dry and
clean surface. Pets normally love it! There is no
possibility to give an overdose of collagen to your
pet as the body naturally eliminates any excess.

24
BIBLIOGRAPHY:
Miller-Keane, Medical Dictionary, 2002.
A. Berton, V. Rigot and al., “Involvement of Type II
Fibronectin in the efficient inhibition of gelatinases
A and B by long-chain unsaturated fatty acids”,
Journal of Biological Chemistry, June 2001.
Alex Suth, DC, during a personal interview, April
2003.
Shelton, Gene, “Collagen and arthritis”, Health
Remedies Notebook, 2002.
National Cardiovascular Disease Statistics, Office
of the Surgeon General, Washington D.C 2003.
“Effects of oral administration of collagen on
rheumatoid arthritis”, a Harvard School of Medicine
study published in the Journal of Science, Boston,
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Cochran, Charles, “Lubricate your joints”,
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2001.
Christopher M. and al., “The hierarchical role in
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DiGiovanna, Augustine G., “Human Aging:
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Bjorn Steffensen Dagger and al., “The involvement
of Type II fibronectin modules of human gelatinase
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21, 2001.
Leroux J.Y., a well-known Canadian immunologist
specializing in collagen research, speaking during
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of youth”, 2003.
Hunter G.K and al., “Modulation of crystal formation
by bone phosphoproteins: Role of glutamic Acid-
rich sequences in the nucleation of hydroxyapatite
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N.A. Nandriopoulos and al., Arthritis Rheum. 19,
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Olson GB., Savage S, Olson J., “The effects of
collagen hydrolysate on symptoms of chronic
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Sprott H., Muller A., Heine H., “Collagen cross-links
in fibromyalgia syndrome”, Z. Rheumatol. 57 Suppl
2: 52-5, 1998
Gronemann ST., Ribel-Madsen S., Bartels EM.,
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www.emedicine.com
www.arthrite.ca
25
 For more information:
www.genacol.ca
1 (888) 240-3002
Any and all reproduction is strictly prohibited and subject to copyright infringement laws.
Legal deposit: 3rd trimester 2008, National Library of Canada and National Library of Quebec.