Morphology
is a unique feature of Strongylida members, thus making it a useful means for identifying members of this
suborder; it is also used to distinguish members within the
suborder due to dierences in bursa appearance between
species.[2] The vulva of A. caninum females is located at
the boundary of the second and nal thirds of the body.[1]
The teeth of A. caninum are found in the buccal capsule
and divided into three sets.[1][2] Two ventral sets form a
lower-jaw equivalent, while a further set projects from
the dorsal side and loosely equates to an upper-jaw.[2]
Each ventral set has three points with those furthest to
the sides being the largest.[1][8] While the ventral sets are
prominent, the dorsal set is hidden deeper in the buccal
capsule.[1]
A. caninum bends its head end upward (dorsally) which
has in the past been noted as a potential source confusion
when determining how the hookworm is oriented.[2] If it
has recently ingested blood A. caninum is red in colour,
if not it appears grey.[1] A. caninum has an alimentary
canal made up of an esophagus, intestine and rectum
the esophagus is highly muscular reecting its role in
pulling intestinal mucosa into the body when it feeds.[2][3]
Esophageal and anal rings of A. caninum are the source of
nerve bres that extend throughout the body to innervate
sensory organs including amphids and phasmids.[1][3]
4 PATHOGENESIS
Distribution
Freezing, heating above 37 C (99 F), drying or exposing A. caninum to sunlight all give reduced survival of
the free-living stage with rates of infection rising with
temperature provided 37 C is not exceeded.[1][2] A. caninum is therefore largely restricted to warm, moist climates though infections are seen in the USA and southern
Canada where the temperature is sub-optimal.[2] Specic
niches are also able to satisfy the environmental requirements of A. caninum despite not necessarily being in the
tropics, such as mines.[2]
3
3.1
Life Cycle
Transmission via the Environment
4 Pathogenesis
3
up to 0.1mL in 24hrs.[2][5] In a 24hr period A. caninum typically feeds from six sites.[2] This damage to
the mucosa compromises the bodys defences and can
result in secondary infections by microbes.[7] A group
of anticoagulant proteins called AcAPs (A. caninum anticoagulant proteins) which inhibit a range of blood
coagulation factors such as Xa are utilised by A. caninum
to help in the feeding process by preventing clotting and
increasing blood loss.[13][14] These AcAPs are among the
most powerful natural anticoagulants that exist and are a
key reason for anemia being caused and blood being observed in the faeces of infected hosts.[5][14] Blood losses
peak just prior to egg production by the females because
this is when their requirements for food are greatest; the
amount that they are eating is also peaking and so maximal damage to the intestine is being caused.[3]
Diagnosis
7 Vaccination
11
increases in antibody levels of all subclasses and a reduced worm burden.[6] Other studies using the same vaccine have shown statistically signicant 79% reductions
in worm burden resulting from this approach.[18]
Animals with prior exposure to A. caninum show enhanced resistance but careful removal of all worms
from the previous infection results in loss of this
improvement.[11] Studies in mice show resistance due to
past exposure can protect against otherwise lethal worm
doses and that this is a general form of resistance - defence is oered against subsequent infections via either
mouth or skin.[19]
Medication
In Humans
REFERENCES
11 References
[1] Saeed, Sophia (2003). "Ancylostoma caninum". Animal
Diversity Web. Retrieved March 20, 2013.
[2] Marquardt W; Demaree; Grieve (2000). Parasitology and
Vector Bology (2nd ed.). Harcourt Academic. pp. 370
376. ISBN 0124732755.
[3] Olsen W (1986). Animal Parasites: their life cycles
and ecology (3rd ed.). Dover. pp. 399416. ISBN
0486651266.
[4] Miller (1965). Inuence of Age and Sex on Susceptibility of Dogs to Primary Infection with Ancylostoma caninum". The Journal of Parasitology 51 (5): 701704.
doi:10.2307/3276142. PMID 5857264.
[5] Peregrine, Andrew (March 2012). Hookworms in Small
Animals. The Merck Veterinary Manual. Retrieved
March 20, 2013.
[6] Ghosh K, Hotez, P (January 1999).
AntibodyDependent Reductions in Mouse Hookworm Burden
after Vaccination with Ancylostoma caninum Secreted
Protein 1. J Infect Dis. 180 (5): 16741681.
doi:10.1086/315059.
[7] Cheng T (1986). Parasitology and Vector Bology (2nd
ed.). Academic Press. pp. 93, 508. ISBN 0121707555.
[8] Ruppert E (1994). Parasitology and Vector Bology (6th
ed.). Saunders College Pub. p. 293. ISBN 0030266688.
[9] Hawdon J, Narasimhan S, Hotez P (April 1999).
"Ancylostoma secreted protein 2: cloning and characterization of a second member of a family of nematode
secreted proteins from Ancylostoma caninum". Molecular and Biochemical Parasitology 99 (2): 149165.
doi:10.1016/S0166-6851(99)00011-0. PMID 7872431.
10
Economic Burden
12
External links
13
13
13.1
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Images
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