PUBLICATIONS (peer reviewed):

1. Jinwal, U.K , Groshev, A., Zhang, J., Grover, A., Sutariya, V.B. (2014) Preparation and
Characterization of Methylene blue Nanoparticles for Alzheimers disease and other Tauopathies.
Current Drug Delivery, 11, 541-50. PMID:24237400.
2. Braswell, K., Dickey, C.A. Jinwal, U.K (2013) A commentary on: Modulating Molecular
Chaperones Improves Sensory Fiber Recovery and Mitochondrial Function in Diabetic Peripheral
Neuropathy. Experimental Neurology, 241C, 121-124. (*corresponding author).
3. Jinwal, U.K, Koren, J. III, Dickey, C.A. (2013) Reconstructing the Hsp90/Tau Machine. Current
Enzyme Inhibition, 9, 41-45.
4. Totten, D.C., Vuong, M., Litvinova, O.V., Jinwal, U.K., Gulia-Nuss, M., Harrell II, R.A., Benes, H.
(2013) Targeting gene expression to the female larval fat body of transgenic Aedes aegypti
mosquitoes. Insect Molecular Biology, 22, 18-30.
5. Abisambra, J.F. , Jinwal, U.K., Blair, L.J., OLeary, J.C., Li, Q., Brady, S., Wang, L., Guidi, C.,
Zhang, B., Nordhues, B.A., Cockman, M., Suntharalingham, A., Li, P., Jin, Y., Atkins, C.A.,
Dickey, C.A. (2013) Tau accumulation activates the unfolded protein response by impairing
endoplasmic reticulum-associated degradation. The Journal of Neuroscience, 33, 9498-507.
PMID 23719816.
6. Jinwal, U.K., Akoury, E., Abisambra, J.F., OLeary, J.C., Thompson, A. D., Blair, L., Jin, Y.,
Bacon, J., Bryce, N., Cockman, M., Zhang, J., Li, P., Zhang, B., Borysov, S., Vladimir, U.,
Biernat, J., Mandelkow, E., Gestwicki, J.E., Zweckstetter, M., Dickey, C.A. (2013) Imbalance of
Hsp70 family variants fosters tau accumulation. The FASEB Journal, 27, 1450-59.
7. Abisambra, J.F.*, Jinwal, U.K.*, Miyata, Y., Rogers, J., Blair, L., Li, X., Seguin, S.P., Wang, L.,
Jin, Y., Bacon, J., Brady, S., Cockman, M., Guidi, C., Zhang, J., Koren, J., Young, Z.T., Atkins,
C.A., Zhang, B., Lawson, L.Y., Weeber, E.J., Brodsky, J.L., Gestwicki, J.E., Dickey, C.A.(2013)
Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing
aberrant tau. Biological Psychiatry, 74, 367-74. PMID 23607970 (* equal contribution).
8. Miyata, Y., Li, X., Lee, H., Jinwal, U. K., Srinivasan, S., Seguin, S., Young, Z., Brodsky, J.,
Dickey, C. A., Duxin, S., Gestwicki, J. E. (2013) Synthesis and Initial Evaluation of YM-08, a
Blood-Brain Barrier Permeable Derivative of the Heat Shock Protein 70 (Hsp70) Inhibitor MKT077, Which Reduces Tau Levels. ACS Chemical Neuroscience, 4, 930-9. PMID: 23472668.
9. Jinwal, U.K.*, J.H., Abisambra, J.F., Zhang, J., Dharia, S., OLeary, J.C., Patel, T., Braswell, K.,
Jani, T., Gestwicki, J.E., Dickey, C.A.* (2012) Cdc37/ Hsp90 Complex disruption triggers an
autophagic clearance cascade for TDP-43. The Journal of Biological Chemistry, 287, 2481420. (*corresponding author).
10. Kasiappan, R., Shen, Z., Tse, A.K-W, Jinwal, U., Tang, J., Lungchukiet, P., Sun, Y., Kruk, P.,
Nicosia, S.V., Zhang, X., Bai, W. (2012) 1,25-Dihydroxyvitamin D3 Suppresses Telomerase
Expression and Human Cancer Growth through MicroRNA-498. The Journal of Biological
Chemistry, 287, 41297-309.

11. Miyata, Y., Rauch, J. N., Jinwal, U. K., Thompson, A. D., Srinivasan, S., Dickey, C. A., Gestwicki,
J. E. (2012) Cysteine reactivity distinguishes redox sensing by the heat inducible and constitutive
forms of heat shock protein 70 (Hsp70). Chemistry & Biology, 19, 1391-1399.
12. Thompson, A. D., Scaglione, K.M., Presener, J., Gillies, A.T., Chinnaiyan, A., Paulson, H. L.,
Jinwal, U.* K., Dickey, C. A.*, Gestwicki, J. E.* (2012) Analysis of the tau-associated proteome
reveals that exchange of Hsp70 for Hsp90 is involved in tau degradation. ACS Chemical
Biology, 7, 1677-86. (*corresponding author)
13. Suntharalingam, A., Abisambra, J.F., OLeary, J.C., Koren, J. III., Zhang, B., Joe, M.K., Blair,
L.J., Hill, S.E., Jinwal, U.K., Cockman, M, Duerfeldt, A.S., Tomarev, S., Blagg, B.S.J.,
Lieberman, R.L., Dickey, C.A. (2012) Grp94 triage of mutant myocilin through ERAD subverts a
more efficient autophagic clearance mechanism. The Journal of Biological Chemistry, 287,
40661-9.
14. Calcul, L., Zhang, B., Jinwal, U.K., Dickey, C.A., Baker, B.J. (2012) Natural products are a rich
source of tau-targeting drugs for Alzheimers disease. Future Medicinal Chemistry, 4, 1751-61.
15. Koren, J. III., Miyata, Y., Kiray, J., OLeary, J.C., Nguyen, L., Guo, J., Blair, L.J., Jinwal, U.K.,
Cheng, J.Q., Gestwicki, J.E., Dickey, C.A. (2012) Rhodacyanine derivatives selectively targets
cancer cells and overcomes tamoxifen resistance. PLoS ONE, 7, e35566, 1-8.
16. Abisambra, J.F., Jinwal, U.K., Suntharalingam, A., Arulselvam, K. Brady, S., Cockman, M.S., Jin,
Y., Zhang, B., Dickey, C.A. (2012) DnaJA1 antagonizes constitutive Hsp70-mediated stabilization
of tau. Journal of Molecular Biology, 421, 653-61.
17. Jinwal, U.K., Trotter, J.H., Abisambra, J.F., Vestal, G.D., Koren, J. III, Lawson, L.Y., Vestal, G.D.,
OLeary, J.C., Johnson, A.G., Jin, Y., Jones, J.R, Li, Q., Weeber, E.J. and Dickey, C.A. (2011)
The Hsp90 kinase co-chaperone Cdc37 regulates tau stability. The Journal of Biological
Chemistry, 286, 16976-83.
18. Jinwal, U.K. and Dickey, C.A. (2011) Cell-based assays for regulators of Tau Biology.
Alzheimers disease and frontotemporal dementia. Methods in molecular biology, volume 670,
Part1, 93-108, Roberson, Erik D. (Ed.), The Humana Press.
19. Koren, J. III, Jinwal, U.K., Davey, Z., Kiray, J., Aruselvam, K. and Dickey, C.A. (2011) Bending
tau into shape: the emerging role of peptidyl-prolyl isomerases in tauopathies. Molecular
Neurobiology, 44, 65-70.
20. OLeary, J.C., Dharia, S., Blair, L.J., Brady, S., Johnson, A.G., Peters, M., Cheung-Flynn, J., Cox,
M. B., Erausquin, G., Weeber, E.J. Jinwal, U.K., and Dickey, C.A. (2011) Ablation of
FKBP5/FKBP51 as a novel anti-depressive strategy. PLoS ONE, 6, e24840, 1-9.
21. Trotter, J.H., Klein, M., Jinwal, U., Abisambra, J., Dickey, C., Tharkur, J., Masiulis, I., Ding, J.,
Locke, K., Rickman, C., Birch, D., Weeber, E.J. and Herz, J. (2011) ApoER2 function in the
establishment and maintenance of retinal synaptic connectivity. The Journal of Neuroscience,
31, 14413-23.
22. Daily, J.L., Nash, K., Jinwal, U., Golde, T., Rogers, J., Peters, M.P., Burdine, R.D., Dickey, C.,
Banko, J.L., and Weeber, J.E. (2011) Adeno-associated virus-mediated rescue of the cognitive
defects in a mouse model for Angelman syndrome. PLoS ONE, 6(12):e27221.

23. Evans, C.E., Jinwal, U.K., Dickey, C.A., and Gestwicki, J.E. (2011) Identification of
dihydropyridines that reduce cellular tau levels. Chemical Communications, 47, 529-31.
24. Rousaki, A., Miyata, Y., Jinwal, U.K., Dickey, C.A., and Gestwicki, J.E., and Zuiderweg, E.R.P.
(2011) Allosteric drugs: the interaction of anti-tumor compound MKT-077 with human Hsp70
chaperones. Journal of Molecular Biology, 411, 614-32.
25. Shen, Z., Zhang, X., Tang, J., Kasiappan, R., Jinwal, U., Li, P., Hann, S., Nicosia, S., Wu, J.,
Zhang, X., and Bai, W. (2011) The coupling of epidermal growth factor receptor down regulation
by 1alpha,25-dihydroxyvitamin D3 to the hormone-induced cell cycle arrest at the G1-S
checkpoint in ovarian cancer cells. Molecular and Cellular Endocrinology, 338, 58-67.
26. Abisambra, J.F., Jinwal, U.K., Jones, J.R., Blair, L.J., Koren, J. III, and Dickey, C.A. (2011)
Exploiting the diversity of the heat-shock protein family for primary and secondary tauopathy
therapeutics. Current Neuropharmacology, 4, 623-31.
27. Jinwal, U.K.*, OLeary, J.C.*, Borysov, S.I., Jones, J.R, Li, Q., Koren, J. III, Abisambra, J.F.,
Vestal, G.D., Lawson, L.Y., Johnson, A.G., Blair, L.J., Jin, Y., Miyata, Y., Gestwicki, J.E., and
Dickey, C.A. (2010) Hsc70 rapidly engages tau after microtubule destabilization. The Journal of
Biological Chemistry, 285, 16798-16805 (* equal contribution).
28. Jones, J.R., Leber, M., Jinwal, U.K., Abisambra, J.F., Koren, J. III, Blair, J., OLeary, J.C.,
Trotter, J., Johnson, A.G., Weeber, E., Eckman, C.B., Baker, B., and Dickey, C.A. (2010)
Myricanol derived from Myrica cerifera is a novel diarylheptanoid scaffold that destabilizes the
microtubule associated protein tau. Journal of Natural Products, 28, 38-44.
29. OLeary, J.C., Li, Q., Marinec, P., Blair, L.J., Congdon, E.E., Johnson, A.G., Jinwal, U.K., Koren,
J. III, Jones, J.R., Kraft, C., Peters, M., Abisambra, J.F., Duff, K.E., Weeber, E.J., Gestwicki, J.E.,
and Dickey, C.A. (2010) Phenothiazine-mediated rescue of cognition in tau transgenic mice
requires neuroprotection and reduced soluble tau burden. Molecular Neurodegeneration, 5, 45.
30. Abisambra, J.F., Blair, L.J., Hill, S.E., Jones, J.R, Kraft, C., Rogers, J., Koren, J. III, Jinwal, U.K.,
Lawson L., Johnson, A.G., Wilcock, D., OLeary, J.C., Jansen-west, K., Muschol, M., Golde, T.E.,
Weeber, E.J., Banko, J. and Dickey, C.A. (2010) Phosphorylation dynamics regulates Hsp27mediated rescue of neuronal plasticity deficits in tau transgenic mice. The Journal of
Neuroscience, 30, 15374-15382.
31. Jinwal, U.K., Koren, J. III, OLeary, Jones, J.R, Abisambra, J.F., and Dickey, C.A. (2010) Hsp70
ATPase modulators as therapeutics for Alzheimers and other neurodegenerative diseases.
Molecular and Cellular Pharmacology, 2, 43-46.
32. Jinwal, U.K., Koren, J. III, Borysov, S.I., Schmid, A.B., Abisambra, J.F., Blair, L.J., Johnson,
A.G., Jones, J.R, Shults, C., OLeary, J. III, Jin, Y., Buchner, J., Cox, M.B., and Dickey, C.A.
(2010) The Hsp90 co-chaperone, FKBP51, increases tau stability and polymerizes microtubules.
The Journal of Neuroscience, 30, 591-599.
33. Lebson, L., Nash, N., Kamath, S., Herber, D., Carty, C., Lee, D., Li, Q., Szekeres, K., Jinwal, U.,
Koren, J., Dickey, C.A., Gottschall, P., Morgan, D. and Gordon, M.N. (2010) Trafficking CD11bpositive blood cells deliver therapeutic genes to the brain of amyloid depositing transgenic mice.
The Journal of Neuroscience, 30, 9651-9658.

34. Koren, J., Jinwal, U.K., Jin, Y., OLeary, J., Jones, J.R., Johnson, A.G., Blair, L.J., Abisambra,
J.F., Chang, L., Miyata, Y., Cheng, A.M., Guo, J., Cheng, J.Q., Gestwicki, J.E., Dickey, C.A.
(2010). Facilitating Akt clearance via manipulation of Hsp70 activity and levels. The Journal of
Biological Chemistry, 285, 2498-2505.
35. Jinwal, U.K., Miyata, Y., Koren, J., Jones, J.R., Trotter, J.H., Chang, L., OLeary, J., Morgan, D.,
Lee, D., Shults, C., Rousaki, A., Weeber, E.J., Zuiderweg, E.R.P., Gestwicki, J.E. and Dickey,
C.A. (2009) Chemical manipulation of Hsp70 ATPase activity regulates Tau stability. The Journal
of Neuroscience, 29, 12079- 12088.
36. Koren, J., Jinwal, U.K., Lee, D.C., Jones, J.R., Shults, C.L., Johnson, A.G., Anderson, L.J. and
Dickey, C.A. (2009) Chaperone signaling complexes in Alzheimers disease. Journal of Cellular
and Molecular Medicine, 13, 619-630.
37. Dickey, C. A., Kraft, C., Jinwal U.K., Koren, J., Johnson, A., Anderson, L., Lebson, L., Lee, D.,
Dickson, D., De Silva, R., Binder, L., I., Morgan, D. and Lewis, J. (2009) Aging analysis reveals
slowed Tau turnover and enhanced stress response in Mouse model of Tauopathy. The
American Journal of Pathology, 174, 228-238.
38. Dickey, C.A., Koren, J., Zhang, Y.J., Xu, Y.F., Jinwal, U.K., Birnbaum, M.J., Monks, B., Sun, M.,
Cheng, J.Q., Patterson, C., Bailey, R.M., Dunmore, J., Soresh, S., Leon, C., Morgan, D.,
Petrucelli, L. (2008)Akt and CHIP coregulate tau degradation through coordinated interactions.
Proceedings of the National Academy of Sciences of the United States of America (PNAS),
105, 3622-3627.
39. Jinwal, U.K., Zakharkin, S.O., Litvinova, O.V., Jain, S., and H. Bene (2006) Sex, stage and
tissue-specific regulation by a mosquito hexamerin promoter. Insect Molecular Biology, 15, 301311.
40. Zakharkin, S.O., Willis, R.L., Litvinova, O.V., Jinwal, U.K., Headley, V.V. and H. Bene (2004)
Identification of two mariner-like elements in the genome of the mosquito Ochlerotatus atropalpus.
Insect Biochemistry and Molecular Biology 34, 377-386.
41. Tripathi, M.K., Roy, U., Jinwal, U.K., Jain, S.K. and P.K. Roy (2004) Cloning, sequencing and
structural features of a novel Streptococcus lipase, Enzyme and Microbial Technology, 34, 437445.
42. Jinwal, U.K., Roy, U., Chowdhury, A.R., Bhadhuri, A.P. and P.K. Roy (2003) Purification and
characterization of an alkaline lipase from a newly isolated Pseudomonas mendocina PK-12CS
and chemoselective hydrolysis of fatty acid ester (dagger). Bioorganic Medicinal Chemistry, 11,
1041-1046.
43. Tripathi, MK, Jinwal, U.K., Roy, U., Patra, A., Roy, P.K., Batra, S. and A.P. Bhaduri (2002) Effect
of different strains of yeast on stereo-controlled reduction of 5-acetylisoxazolines. Bio-organic
Chemistry, 30, 350-355.
44. Chowdhury, A.R., Tripathi, M.K., Jinwal, U.K., Roy, U., Kumar, V.V., Bhaduri, A.P. and P.K. Roy
(1999) Chemoselective hydrolysis of esters by fungal lipase. Journal of Chemical Research, 4,
266-267.