G 1162
In the United States, 5 of 100 women with a first-degree relative with ovarian
[19]
cancer will eventually get ovarian cancer themselves. This corresponds to a
risk increased by a bit more than twice that of ovarian cancer in the general
[20]
population. 7 out of 100 women with two or more relatives with ovarian
cancer will eventually get ovarian .
A long-standing hypothesis that has considerable support via animal model studies is the
incessant ovulation hypothesis. According to this, "repeated cycles of ovulation-induced
trauma and repair of the OSE [ovarian surface epithelium] at the site of ovulation, without
pregnancy-induced rest periods, contributes to ovarian cancer development." [32] Analysis of
316 high-grade serous ovarian adenocarcinomas found that the TP53 gene was mutated in
96% of cases.[33] Other genes commonly mutated were NF1, BRCA1, BRCA2, RB1 and cyclindependent kinase 12 (CDK12).
Dietician
Rdesum08
Attending Physician