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Nature Reviews Neuroscience

Volume 16, No 2 February
2015
FEATURED ARTICLE
Spatial cognition in bats and
rats: from sensory acquisition
to multiscale maps and
navigation
2013 ISI Impact Factor 31.376*
Next issue date: 20 February

Maya Geva-Sagiv, Liora Las,

Yossi Yovel & Nachum Ulanovsky

2015
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CURRENT ISSUE
Review
Redefining the
cerebellar cortex as an
assembly of
non-uniform Purkinje cell
microcircuits
Nadia L. Cerminara, Eric J. Lang,
Roy V. Sillitoe & Richard Apps

CURRENT ISSUE
Review
Spatial cognition in bats
and rats: from sensory
acquisition to multiscale
maps and navigation
Maya Geva-Sagiv, Liora Las, Yossi
Yovel & Nachum Ulanovsky
Although we understand much

The cerebellar cortex drives smooth

about mechanisms of spatial

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goal-directed movement as well as a

navigation in the mammalian brain

range of other functions. Apps and

in the context of laboratory

colleagues describe studies that have

investigations, our knowledge of the

revealed variations in the

neural bases of 'real-world'

cytoarchitecture, molecular

navigation is more limited.

composition, physiological

Ulanovsky and colleagues here

properties and vulnerability to cell

describe how we can approach this

death of different cerebellar cortical

problem through experimental

regions, and discuss the idea that

research and theoretical models of

these underlie different forms of

large-scale navigation in bats and

information processing.

rats.

CURRENT ISSUE

CURRENT ISSUE

Review

Progress

Spreading of pathology
in neurodegenerative
diseases: a focus on
human studies

Opioid and chemokine

receptor crosstalk: a
promising target for
pain therapy?

Johannes Brettschneider, Kelly Del

Tredici, Virginia M.-Y. Lee & John
Q. Trojanowski

Stphane Mlik Parsadaniantz,

Cyril Rivat, William Rostne &
Annabelle Raux-Le Goazigo

Various neurodegenerative diseases

Chemokine receptors and opioid

are characterized by aggregates of

receptors in nociceptive pathways

pathological proteins, and

interact in ways that can alter opioid

increasing evidence suggests these

function. In this Progress article,

disease-associated proteins may

Raux-Le Goazigo and colleagues

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'spread' via neuronal connections.

discuss how crosstalk between

Trojanowski and colleagues describe

chemokine and opioid receptors

the molecular mechanisms of such

offers a new framework for the

spreading, and present the findings

development of novel analgesic

from neuropathological and imaging

therapies to alleviate pain.

studies in humans that support this

process.

PREVIOUS ISSUE
Review
The mechanisms and
functions of
spontaneous
neurotransmitter release
Ege T. Kavalali
It was traditionally assumed that the

CURRENT ISSUE
Research Highlights
Pain:
Converging on LTP
Neurodegenerative
disease:
Restoring balance in
Huntington disease

spontaneous release of
neurotransmitter-containing
vesicles at neuronal synapses results

Behavioural
neuroscience:
Swarming away from smells

from the random activation of the

vesicle fusion machinery that
underlies action potential-driven
evoked release. However, the recent

Neurodegenerative
disease:
Factoring in astrocytes

evidence described by Kavalali in

this Review now suggests that the

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mechanisms, regulation and

functions of spontaneous
neurotransmitter release are distinct
from those of evoked
neurotransmission.

MORE NEUROSCIENCE
Web Focus Collection

Neuroscience Conferences

Selected articles from the Nature

A calendar of forthcoming meetings

Publishing Group

from across the field of neuroscience.

Neuropod

Recommended Links

Neuroscience podcast from

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Nature

NOTICEBOARD
The endocannabinoid system
Although cannabis has been used for centuries as a recreational drug,
the mechanisms of action of its active constituents (cannabinoids)
and their endogenous counterparts (endocannabinoids) have only
been discovered relatively recently. Nature Reviews Neuroscience
presents a series of articles that examine the multiplicity of roles of
the endocannabinoid system in the CNS, from development to
behaviour, and the potential for cannabinoid-based therapies in the
treatment of a range of brain disorders.

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Poster on BDNF function in health and disease

Brain-derived neurotrophic factor (BDNF) is the most widely
expressed and well-characterized member of the neurotrophin family
in the mammalian brain. Nature Reviews Neuroscience presents a
Poster on the diverse roles of BDNF in the developing and mature
nervous system. The Poster is freely available thanks to support from
EVER Neuro Pharma.
Neuroscience and the law
New insights into the neural processes that underlie cognition and
behaviour have led to discussions about the relevance of these
discoveries for the criminal justice system. Conversely, laws can
influence neuroscience, for example, with regard to psychoactive
drugs and stem cell research. Nature Reviews Neuroscience presents
a series of articles that explore the interaction between neuroscience
and the law.
Chronic pain collection
This Nature Collection brings together articles from Nature, Nature
Medicine, Nature Neuroscience, Nature Reviews Neurology and
Nature Reviews Neuroscience that highlight recent advances towards
understanding the risk factors and mechanisms that underlie chronic
pain, and developing effective, non-addictive treatments for this
highly prevalent condition. These articles are freely accessible for 6
months thanks to support from the NIH Pain Consortium.
Neural circuits series
A fundamental goal of neuroscience research is to understand how

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the brain's neural circuits are structurally and functionally connected.

Nature Reviews Neuroscience presents a series of articles that
explore various approaches to the analysis of the structure and
function of neural circuits and describe recent methodological
advances that are driving research.
Brain ageing series
A special series of articles examining the hallmarks of ageing in the
brain, the mechanisms underlying brain ageing and the implications
for brain function and disease susceptibility. These articles cover the
latest findings at the genetic, cellular, circuit and behavioural levels in
humans and model organisms, and explore the intrinsic and extrinsic
factors that affect the ageing process, as well as potential strategies to
slow it down.
Focus on Addiction
This Focus issue features five articles that discuss recent insights into
the neurobiology of addiction from the molecular to the
behavioural level and highlight the importance of these findings for
the development of new treatments.

2013 Journal Citation Report (Thomson Reuters, 2014)

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