ISSN - 0974-2441
ReviewArticle
MAYTENUSEMARGINATA(WILLD.):APROMISINGDRUGFORCANCERTHERAPY
*SAVITASAGWAN,D.V.RAO,R.A.SHARMA
Biotechnologylab,DepartmentofBotany,UniversityofRajasthan,Jaipur,India
Email:savita.sagwan@gmail.com
ABSTRACT
Therearehundredsofmedicinalplantsthathavealonghistoryofcurativepropertiesagainstvariousdiseasesandaliments.Maytenusemarginata
(Willd.)(Family:Celastraceae)isanevergreentree thatholdsaplaceofexceptionalarroganceamong thevariousplantsbecauseofitsimmense
medicinalusesofgreatsignificance.PlantextractsofthecelastraceaehavebeenusedforcenturiesthroughoutSouthAmericaandChinaasinsect
repellentsandinsecticidesintraditionalagriculture,andalsoforthetreatmentofaplethoraofmedicalailmentsfromstomachcomplaintsandfever
torheumatoidarthritisandcancer.PhytochemicalinvestigationofMaytenusemarginata(Willd.)hasbeencompiledforthestudyofclinicaluseof
thisplant.Theactivecompoundsincludeemarginatine[A],[B],[E],[F],[G]andemarginatininearediscussedbrieflywiththerecentadvancesand
mechanismoftheiraction.Thisarticlebrieflyreviewsthebotany,distribution,ecology,usesoftheplantandasadrugforcancertherapy.Thisisan
attempttocompileanddocumentinformationondifferentaspectofMaytenusemarginataanditspotentialuseasadrugsourcefordifferenttumor
cells.
Keywords:Maytenusemarginata(Willd.),Emarginatine,Emarginatinine,Cancertherapy,Tumorcells.
INTRODUCTION
Chemotherapy is a kind of treatment that uses drugs to attack
cancer cells. It is called a "systemic treatment" since the drug,
enteringthroughthebloodstream,travelsthroughoutthebodyand
killscancercellsattheirsites.Thedrugsmayrarelybeintendedto
have a local effect, but in most cases, the intention is to destroy
cancercellswherevertheymayexistinthebody.Chemotherapeutic
drugs are chemically designed to target cells that are dividing and
growingrapidly.
Once they reach the cancer cells, they act to retard their growth,
eventually resulting in their destruction. Chemotherapy works by
stopping or slowing the growth of cancer cells, which grow and
dividequickly.Theeraofcancerchemotherapybeganinthe1940s
with the first use of nitrogen mustards and folic acid antagonist
drugs. Cancer drug development has exploded since then into a
multibillion dollar industry. The celastraceae family, commonly
known as bittersweet family, is indigenous to tropical and sub
tropicalregionsoftheworld,includingNorthAfrica,SouthAmerica,
andmanypartsofEastAsia,ParticularlyChina[1,2].
Plantsofthisfamilygenerallygrowassmalltrees,bushesor lianas
and have resinous stems and leaves. They have been valued since
antiquitybecausetheirextractshaveusefulmedicinalproperties [3].
Thecrudeplant extractsofthecelastraceaeintraditionalmedicine
and agriculture is astonishing, and includes stimulant, restorative,
male contraceptive, antitumor, antileukemic, antibacterial,
insecticidalandinsectrepellentactivities[4].
Maytenus emarginata (Willd.) belongs to family celastraceae, is an
evergreentreethattoleratesvarioustypesofstressesofthe desert,
locallyknown as Kankero in Hindi, Thorny staff treeinEnglish.
TraditionallyspeciesofMaytenushasbeenusedforfever,asthama,
rheumatismandgastrointestinaldisordersworldwide.
Recently some biomolecules from Maytenus species has been
reported to be active against HIVProtease [5] Carcinoma and
leukemia [6]. Ulcers [7]and MDR(Multi DrugResistance) [8]. Various
partsofthisplantcontainimmensemedicinalpropertieswhich are
mentionedunder:
RootUsedingastrointestinaltroubles,especiallydysentery [9].
StemTendershootsoftheplanthelpformouthulcer.Thebark
isgroundto a paste and applied withmustard oil tokilllice in
thehair.
tohealupsoresand woundgivescoolingeffect.Theleavesare
burnt and mixed with ghee to form an ointment used to heal
sores [11].Thetenderleavesarechewedrawinthetreatmentof
jaundice.
FruitThefruitsareusedinmedicinestopurifyblood[12].
BOTANICALCLASSIFICATION:
Kingdom
Plantae
Phylum
Magnoliophyta
Class
Magnoliopsida
Order
Celastrales
Family
Celastraceae
Genus
Maytenus
BOTANICALNAME:Maytenusemarginata(Willd.)DingHou
SYNONYMS:
CelastrusemarginatusWilld.
Gymnosporiaemarginata(Willd.)Thw.
GymnosporiaMontana(Roth)Benth.
COMMONNAMES:
Hindi
Vinger,Kankero,Baikal,Malkangni
English
Thornystafftree
Sanskrit
Vikankata,Sudhavridsha
Bengali
Bakundri,Vaichigacha
Kannada
:
Tandrasi,Tandraja,Haalumanike,
Malega,Malkaamguni
Malayalam
Katoupatsjotti,Kanguni
Marathi
:
Baefal,Baekar,Bhaaroolee,Bharatti,
Bharuli,Harmocha,Vekal,Vekar,
Yekkadi
Tamil
Kattangi,Nandunarani,ValuluVai
Telugu
:
Chinni,Danthi,Sinni,Danti,Chinni
tuppa,ChinnichettuGoddalicippa
Gujarati
Vickado
Sagwanetal.
AsianJPharmClinRes,Vol4,Issue3,2011,912
BOTANICALDISCRIPTION
ThemembersofCelastraceaefamilygenerallyaretreesandshrubs
comprising about 55 genera and 850 species that are sometimes
climbingorvining [13].Maytenusemarginataisasmall,compacttree,
35meterhigh;youngbranchespurple,oftenspiny,withleavesand
flowersonthespines.Allthebotanicaldescriptivecharactersofthis
plantarelistedinTable1.
Table1:BotanicalDescriptionofMaytenusemarginata(Willd)
Planttype
Growing
requirements
(a)
Bark
(b)
Leaf
(c)
Flower
(d)
Fruit
(e)
Root
Pest
diseases
and
Lightrequirement:Fullsunwithmiddayshade
Soiltolerances:Sandysoil,limestone
Bestseason:Monsoon
Droughttolerance:Varioustypes of stressesof
thedesert
Palebrown,smooth,cracked(Figure.B)
Taproot,Creamyellowincolor(Figure.F)
Troublefree
FigureA.Maytenusemarginata(Willd.)Plant
FigureB.Bark
FigureC.Leaf
FigureD.Flower
FigureE.Fruit
FigureF.Root
DISTRIBUTION:
ThespeciesisgloballydistributedinPaleotropics.WithinIndia,itis
commonindryscrubforeststhroughout,particularlyonpoorsoils
in Central and Western peninsular India. The genus Maytenus
distributed in drier parts of Central, SouthWestern and North
WesternIndia.
Sagwanetal.
AsianJPharmClinRes,Vol4,Issue3,2011,912
In Rajasthan its found in Ajmer: AjmerUdaipur road, kota:
Shahabad, Pali: Gurupratap singh village, Sirohi: Vadakhoda, Tonk:
Rajmahal,DoogorBeed(Nagaur),FahelpurBeed(Sikar),SikerBeed
(Siker),Nokha(Bikaner),KarniMataOran,Deshnoke(Bikaner),Shri
Balaji (Nagaur), Chohta (Barmer), Shri MukamNokha (Bikaner),
Khejarali(Jodhpur),NurseryofRajasthanUniversity,JhalanaDungri
(Jaipur).
Manycharacteristicbioactivecompounds,suchasmaytansinoids [16]
with antitumor activity, quinoid triterpenes [17, 18] and triterpene
dimmers [19, 20] with cytotoxic activity, sesquiterpene pyridine
alkaloids [21, 22] with insect antifeedant [23] and immunosuppressive
activites [24] and sesquiterpene polyesters [25] with antitumor
promoting activity [26] are reported from genus Maytenus or the
familyCelastraceae.
ECOLOGY:
In the search for potential antitumor agents from the plant family
Celastraceae, several cytotoxic sesquiterpene pyridine pyridine
alkaloidsarepresent[27,28]whichareasmentionedunder:
EmarginatineE(Fig.1c)exhibitedcytotoxicityagainstKB(ED 50
=1.7g/ml)andCOLO205(ED50=4.1g/ml)cancercells[31].
Italsoshowedinterestingresultsagainstthemurineleukemia
cell line P388 (ED50 = 0.69 gml1) and against the human
colon adenocarcinoma cell line HCT8 (ED50 = 1.29 gml1).
However, an ambiguous result was obtained for cytotoxicity
against the human lung carcinoma cell line A549 (ED50 = 5.5
gml1).
PROPAGATION:
Maytenus emarginata is an out breeding tree therefore it shows
greatvariability.Sowseedunderglassinseasonofautumn.Remove
suckers, which may appear at somedistance fromthe parent plant
in spring season. Root semiripe cuttings with bottom heat in
summer.
GROWTHPATTERNS:
Maytenusemarginata(Willd.)growinmoderatelyfertile,moist but
welldrained soil in full sun with midday shade. Fruit appears in
January to February and fruit ripens start from March to April.
Flowers appears in October to January. Develops new leaves from
JunetoAugustasshowninTable2.Thebestseasonforcollectingof
thisplantformedicinalusesismonsoon.
Table 2: General growth pattern of Maytenus emarginata
(Willd)
J
Mo
a
nth
n
s
F
e
b
M
a
r
A
p
r
M
a
y
J
u
n
J
u
l
A
u
g
S
e
p
O
c
t
N
o
v
D
e
c
Pla
nt
Par
ts
Ne
w
leaf
Flo
wer
Fru
it
Fru
it
rip
en
MAYTENUSEMARGINATA:PROMISINGDRUGFORANTICANCER:
The majority of chemotherapeutic drugs can be divided into
alkylating agents, antimetabolites, anthracyclines, plant alkaloids,
topoisomeraseinhibitorsandotherantitumoragents[14].
Over the last 30 years or so, a large number of secondary
metabolites exhibiting a wide range of bioactivity have been
extracted from the Celastraceae. The bioactive metabolites of the
genusMaytenusinplantsbelongstofamilyCelastraceae,which are
widelyusedasfolkmedicinesinSouthAmerica[15].
11
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AsianJPharmClinRes,Vol4,Issue3,2011,912
S.No
Fig.1a
Fig.1b
Fig.1c
Fig.1d
Fig.1e
Compound
EmarginatineA
EmarginatineB
EmarginatineE
EmarginatineF
EmarginatineG
R1
OAc
OAc
OAc
OH
OAc
R2
OAc
OBz
OH
OAc
OAc
R3
OAc
OAc
OAc
OAc
OAc
R4
OAc
OAc
OH
OBz
OMbu
R5
OPy
OPy
OPy
OPy
OPy
R6
CH3
CH3
CH3
CH3
CH3
R7
OH
OH
OH
OH
OH
R8
OAc
OAc
OAc
OAc
OAc
9.
10.
11.
12.
13.
14.
15.
Figure2:ChemicalstructureofEmarginatinine
CONCLUSION:
The present study revealed that Maytenus emarginata shows
significantantitumorpropertiesthatsupporttouseinthetreatmentof
cancer. These new leads could be further modified through analog
studies to yield useful compounds or to be subjected to biochemical
and pharmacological investigation to increase the understanding of
cancer cell biology. The sesquiterpene pyridine alkaloids reviewed
above are only one division of antitumor agents from Maytenus
emarginata plant. The number of the alkaloids and their analogs
discussed above has already been in preclinical or clinical trials and
someofthemarenowusedinclinics.Thispropertycouldbeexploited
fortheadvantageofcancerpatients.Continuinginvestigation onthis
plantderivedalkaloidswillundoubtedlyresultinthedevelopmentof
moreselectiveandeffectivenovalanticancerdrugs.
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