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The study compared the healing time of second-degree burns in rats treated with ethanolic extract cream from senduduk leaves, MEBO ointment, or moist dressing. Eighteen rats with burns were divided into three groups treated with each substance. The healing time was recorded daily until wounds were fully recovered. There was no significant difference in healing time between the senduduk leaf extract cream and MEBO groups, but the moist dressing group had a significantly longer healing time. The senduduk leaf extract cream was as effective as MEBO in healing second-degree burns in rats.
The study compared the healing time of second-degree burns in rats treated with ethanolic extract cream from senduduk leaves, MEBO ointment, or moist dressing. Eighteen rats with burns were divided into three groups treated with each substance. The healing time was recorded daily until wounds were fully recovered. There was no significant difference in healing time between the senduduk leaf extract cream and MEBO groups, but the moist dressing group had a significantly longer healing time. The senduduk leaf extract cream was as effective as MEBO in healing second-degree burns in rats.
The study compared the healing time of second-degree burns in rats treated with ethanolic extract cream from senduduk leaves, MEBO ointment, or moist dressing. Eighteen rats with burns were divided into three groups treated with each substance. The healing time was recorded daily until wounds were fully recovered. There was no significant difference in healing time between the senduduk leaf extract cream and MEBO groups, but the moist dressing group had a significantly longer healing time. The senduduk leaf extract cream was as effective as MEBO in healing second-degree burns in rats.
Comparison of topical application of ethanolic extract cream of senduduk leaves
(Melastoma malabathricum L.), Moist Exposed Burn Ointment (MEBO) and Moist Dressing on healing time of second-degree burns in Rat (Rattus norvegicus)
By: Dedy Purnama
The efficacy of senduduk leaves (Melastoma malabathricum L.) for burn
wound healing has not been known clinically. Senduduk leaves have active compounds which contribute in accelerating of burn wound healing, with a complex process. This study aimed to compare the healing of time second-degree burns in rats treated with extract cream of senduduk leaves, MEBO and aquadest (moist dressing). Eighteen male Wistar rats 200-300 g body weight were randomly divided into three groups. Group I was treated with extract cream of senduduk leaves, group II was treated with MEBO, group III was treated with aquadest. The healing time was counted every day since first day of treatment until the burn wound recovered completely. The results showed there was no different in healing time between group I and group II (p = 0.634) statistically but a significant difference found if compared with group III (p = 0.001). In conclusion, the extract cream of senduduk leaves showed the same efficacy with MEBO and better effect than aquadest on second degree burn wound healing in rats.
Keyword:
ethanolic extract cream of senduduk leaves, MEBO, moist
dressing, healing time, second-degree burns
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ABSTRAK
Perbandingan Pemberian Krim Ekstrak Etanol Daun Senduduk
(Melastoma malabathricum L.), Moist Exposed Burn Ointment (MEBO) dan Moist Dressing Secara Topikal Terhadap Penyembuhan Luka Bakar Derajat II Pada Tikus Putih (Rattus norvegicus)
Oleh: Dedy Purnama
Manfaat dari daun senduduk (Melastoma malabathricum L.) terhadap
penyembuhan luka bakar secara klinis belum banyak diketahui. Daun senduduk memiliki senyawa aktif yang berperan mempercepat penyembuhan luka bakar, dimana penyembuhannya membutuhkan proses yang sangat kompleks. Penelitian ini bertujuan untuk membandingkan waktu penyembuhan luka bakar derajat II pada tikus yang diterapi dengan krim ekstrak daun senduduk, MEBO dan aquadest (moist dressing). Delapan belas ekor Rattus norvegicus jantan galur Wistar dengan berat 200-300 gram secara acak dibagi dalam tiga kelompok uji. Kelompok I diterapi dengan krim ekstrak daun senduduk, kelompok II diterapi dengan MEBO, kelompok III diterapi dengan aquadest. Waktu penyembuhan dinilai dari penghitungan setiap hari luas luka bakar mulai dari hari pertama perlakuan hingga luka menutup sempurna. Uji statistik menunjukkan tidak ada perbedaan waktu penyembuhan luka bakar antara kelompok I dengan kelompok II (p=0,634) namun menunjukkan perbedaan yang signifikan jika dibandingkan dengan kelompok III (p=0,001). Dapat disimpulkan, krim ekstrak daun senduduk memiliki efektifitas yang sama dengan MEBO dan lebih baik dibandingkan dengan aquadest dalam penyembuhan luka bakar derajat II pada tikus.
Kata kunci: Krim ekstrak etanol daun senduduk, MEBO, moist dressing, waktu .penyembuhan, luka bakar derajat II.