E55
RESULTS: Between September 2002 and November 2003, 1164 ICU patients with CVCs were enrolled. Patients
during each study phase were similar with respect to gender, underlying disease, severity-of-illness score, and
central venous catheter longevity. Compliance with CVC care was similar during the two study phases.
Handwashing compliance was above 75%, and the presence of an occlusive sterile catheter dressing was above
98% during both phases of the study. There was a total of 4584 CVC days during phase one and 3995 CVC days
during phase two. The rate of CVC-associated BSI (laboratory-conrmed bloodstream infection, or LCBI, and
clinical sepsis, or CSEP) during phase one was higher than during phase two (16.97 versus 3.00 BSIs per 1000 CVCdays, RR = 0.18, 95% CI = 0.10-0.32, p=0.0000).
In a previous study we quantied the attributable extra costs of CVC-associated BSI in the same ICUs. CVCassociated BSIs extended ICU average length of stay by 6.05 days and resulted in added ICU costs of $6899 per
patient. With a baseline CVC-associated BSI rate of 16.97 per 1000 CVC-days, 67 BSIs would have been expected to
occur during the 3995 line-days over 21 ICU-months of phase two. During this time using the closed system, we
documented 12 BSIs instead of 67, a reduction of 55 BSIs. This resulted in a reduction of 332.75 ICU days and a
calculated cost savings during the 21 ICU-month intervention period of $379,445. This corresponds to 15.84 days
and $18,069 saved per ICU per month, or a saving of 190 days and $216,826 per ICU per year.
CONCLUSION: Adoption of a closed infusion system in four ICUs of three Mexican hospitals resulted in signicant
reduction in BSI rates and costs, with a savings of 190 ICU days and $216,826 per ICU per year.
Device-Related Infections
Abstract ID 50571
Monday, June 20
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Vol. 33 No. 5
associated with latex. Based on these patient and provider safety benets, silver-coated 100% silicone Foley
catheters are the standard of care at this medical center.
Abstract ID 50644
Monday, June 20
Abstract ID 51455
Tuesday, June 21