Table of Contents
Obstetrics.......................................................................................................................................................................................................2
Normal pregnancy / Prenatal care............................................................................................................................................................2
Early Pregnancy Complications..................................................................................................................................................................4
Prenatal Screening...........................................................................................................................................................................................5
Normal L&D........................................................................................................................................................................................................7
Antepartum Hemorrhage..............................................................................................................................................................................9
L&D Complications........................................................................................................................................................................................10
Fetal complications of pregnancy...........................................................................................................................................................11
Hypertension & Pregnancy........................................................................................................................................................................13
Diabetes in pregnancy.................................................................................................................................................................................14
Infectious Diseases in Pregnancy............................................................................................................................................................15
Infections that can affect the fetus (TORCH, etc)........................................................................................................................16
Other Medical Complications of Pregnancy........................................................................................................................................17
Postpartum care / complications............................................................................................................................................................19
Gynecology................................................................................................................................................................................................21
Benign Lower Genital Tract Disorders..................................................................................................................................................21
Benign Upper Genital Tract Disorders..................................................................................................................................................23
Endometriosis / Adenomyosis.................................................................................................................................................................24
Lower reproductive tract infections......................................................................................................................................................25
Upper reproductive tract infections.......................................................................................................................................................27
Pelvic organ prolapse...................................................................................................................................................................................28
Urinary Incontinence...................................................................................................................................................................................29
Puberty...............................................................................................................................................................................................................30
Menopause.......................................................................................................................................................................................................30
Amenorrhea.....................................................................................................................................................................................................31
Menstrual cycle abnormalities.................................................................................................................................................................32
Hirsutism & Virilization..............................................................................................................................................................................33
Contraception / Sterilization....................................................................................................................................................................34
Elective Termination of Pregnancy........................................................................................................................................................35
Infertility and Assisted Reproductive Technologies........................................................................................................................36
Vulvar / Vaginal Neoplasia........................................................................................................................................................................38
Cervical Neoplasia / Cancer.......................................................................................................................................................................39
Endometrial Cancer......................................................................................................................................................................................40
Ovarian Tumors..............................................................................................................................................................................................41
Gestational Trophoblastic Disease..........................................................................................................................................................43
Breast Disease & Breast Cancer...............................................................................................................................................................45
Benign breast disease............................................................................................................................................................................45
Malignant breast disease:.....................................................................................................................................................................46
Other random stuff........................................................................................................................................................................................47
Obstetrics
Normal pregnancy / Prenatal care
Nutritional stuff
Folate stuff:
4mg/day folate if previous hx NTD, on carbamazepine or valproate, or pregestational DM
Otherwise 0.4-0.8 mg/day for all other women of reproductive potential
Weight gain in pregnancy: dont ever want to lose weight, just gain less if overwt.
Underweight (BMI < 18.5)
28-40 lbs.
Normal wt (BMI 18.5-24.9)
25-35 lbs.
Overweight (BMI 25-30)
15-20 lbs
Obese (BMI > 30)
11-20 lbs
Add 300kcal/day in pregnancy, 500kcal/day in breastfeeding.
Antenatal screening:
First trimester (NT/ nasal bone on U/S and PAPP-A/free b-hCG bloodwork) @ 11-13 wks
Can do CVS around 9-12 wks if concerns, > 1:200 risk miscarriage
Quad screen (MSAFP, b-hCG, estriol, inhibin A) @ 18-20 wks
Can do amnio after ~ 15wks if concerns, 1:200ish risk miscarriage
Anatomy screening U/S @ 18-20 wks also.
Glucose loading test @ 27-29 wks (earlier if multiples / hx).
GLT: 50g challenge, check in 1 hr, if 140 or more, go to OGTT
OGTT: 100g challenge, measure fasting and at 1,2,3h. Should be less than 95/180/155/140.
6wk PP: 75g challenge, measure in 2 hrs.
BPP: 0 or 2 scoring for AFI, fetal tone, fetal activity, breathing movements, NST
U/S with cord doppler if worried for placental insufficiency (decrease / reversal of flow)
NST: in 20 min, need 2 accels that are 15 bpm above baseline x 15 seconds
U/S if worrisome.
Contraction stress test: get 3 ctx in 10m, analyse FHR
Fetal lung maturity:
L/S ratio > 2 = RDS is rare
also use phosphatidylglycerol, saturated phosphatydal choline, surfactant / albumin ratio, lamellar body ct
Routine pregnancy problems
Lower back pain stretching, gentle excercise, Tylenol, massage, heating pads
Constipation drink water, colace. Avoid laxatives in 3rd tri (increased PTL?)
Contractions if braxton-hicks, drink lots of water (vasopression oxytocin receptors), reassure.
If q10m or less, think PTL & bring in to check cervix. If no change, reassuring.
Edema (compressed IVC) elevate legs, sleep on side if helps, worry for PEC if hands/face
GERD many small meals, start antacids, dont lay down right after eating. H2 blockers / PPI if persists.
Hemorrhoids: 2/2 IVC compression topical anesthetics, steroids, prevent constipation
Pica tell pt to stop, get good nutrition instead. If toxic substance, call poison control or toxicology
consult
Round ligament pain: late in 2nd tri / early in 3rd, adnexa / lower abdomen / shoots to labia. Warm
compresses or acetaminophen.
incompetent cervix: 2/2 surgery, trauma, ?DES, or idiopathic. Can do cerclage, both if hx
in previous pregnancy or in emergency. If elective, place at 14 wks (2/2 chance of 1st
trimester sab). Consider betamethasone / tocolysis if close to 24 wks.
Habitual aborters (3+ consecutive SABs)
W/U:
Consider if hx DVT, prolonged DRVVT, anticardiolipin abs, recurrent first trimester losses.
get luteal phase serum progesterone and/or endometrial bx in luteal phase to look for
proliferative endometrium).
Factor V Leiden: consider if late fetal demise (late 3rd trimester), with head > abdominal, fetal,
humerus lengths, pt with hx of DVT in the past
Tx: may need IVF (translocations, etc), surgery for anomalies, heparin / aspirin, maternal tx
Septic abortion - miscarriage with fever, uterine tenderness, etc.
Need uterine evacuation and broad spectrum abx
Prenatal Screening
Remember PPV = % pts with positive screen that are affected; NPV = % pts with negative screen not affected, +LR
and -LR tell you how to adjust pretest odds to get posttest odds
Remember, for an autosomal recessive disease, the sibling of an affect pt has a chance of being a carrier.
Example: Dads brother has sickle cell disease. Neither parent has been checked. Dad has chance of
being a carrier; Mom has 1/12 (population risk), so risk for affected child is (1/2) x (1/12) x (1/2) x (2/3)
Also remember Hardy-Weinberg: p2 + 2pq + q2 = 1 @ equilibrium where p, q = allele frequencies, p2 / q2 =
homozygotes, 2pq = heterozygotes
Cystic fibrosis: Aut-rec, CFTR gene, chloride channel, commonly deltaF508 / G542x but 1000+ mutations known
sx: lung / cor pulmonale / pancreatic insufficiency / infertility
1/29 Caucasians are carriers; screen parents, then with CVS / amnio if both parents carriers (1/4 risk)
Sickle-Cell: Aut rec, vaso-occlusive crises, hemolytic anemia
Screen mom with hemoglobin electophoresis, then dad if patient carries HBs
Carrier frequency: 1/12 in African Americans
Tay-Sachs: aut rec, hexosamindase A deficiency GM2 gangliosides build up.
Carrier freq: 1/27 in Ashkenazi Jews, also eastern Europeans
3-10mo after birth: hyperacusis, loss of alertness, myoclonic / akenitic seizures, cherry red spot in macula.
Gray matter lysosomal storage disease.
Thalassemias: hemolytic anemia, RBC destroyed in bone marrow / liver / spleen
Beta-thal: AR, in Mediterranean descent (also Asia / Africa). Too few beta chains usually presents
postnatally (when beta normally replaces gamma). Screen with CBC (mild hemolytic anemia with low
MCV), then get Hb electrophoresis (shows more alpha than beta Hgb A2).
Alpha-thal: AR, too few alpha chains. 4 alpha genes, 2/4 mutations can be cis (Asians) or trans (Africans).
If both parents have cis mutations = 25% infants will get severe form; trans = usually will become carrier.
4 genes: fetal hydrops, incompatible with life, splenomegaly, etc. Hb electrophoresis shows no
HbF, no HbA, lots of Hb Barts (4 gammas)
3 genes: HbH disease beta chains build up, oxidative damage destruction, Hb electrophoresis
shows Hb barts & HbH (beta tetramers), barts goes away as gamma chains replaced.
2 genes: trait. Mild phenotype, microcytic anemia.
Screen with CBC, then Hb electrophoresis.
Chromosomal abnormalities
Quad screen: first thing to do = verify the dates & r/o multiple gestation!!
MSAFP
Estriol
B-hCG
Inhibin-A
Trisomy 21
Low
Low
High
High
Trisomy 18
Low
Low
Low
normal
Trisomy 13
depends on defects
depends on defects
depends on defects
depends on defects
NTD
High
Down syndrome: flattened nasal bridge, small size, cup-shaped ear, sandal-gap toes, hypotonia, simian
crease, epicanthic fold, oblique palpebral fissures, protruding tongue, short, broad hands.
Higher rates of stillbirth, miscarriage. IQ 40-90. A/w duodenal atresia, cardiac defects, short
limbs, nasal bone hypoplasia.
echogenic intracardiac focus only has LR of 2.0, so at most doubles pretest odds.
Trisomy 18 = Edward: Clenched fists, overlapping digits, rocker bottom feet, VSD / tetFal, omphalocele,
CDH, NTD, choroid plexus cysts. Fetal / neonatal death.
Trisomy 13 = Patau. holoProsencephaly, cleft lip and Palate, cystic hydroma, single nostril, omphalocele,
hypoPlastic left heart, clubfoot / hand, Polydactyly, overlapping fingers.
Turner syndrome = XO: wide-spaced nipples, shield-like chest, lymphedema, primary amenorrhea,
coarctation of aorta, short 4th metacarpal, receding hairline
Klinefelter syndrome = 47,XXY. small, firm testes, hyalinized seminiferous tubules, infertility,
gynecomastia, MR, elevated gonadotropin levels.
Congenital anomalies:
Organogenesis: wks 3-8 after conception (wks 5-10 EGA). Insult before = probably will lose pregnancy.
Radiation during weeks 8-15 has greatest risk of fetal microcephaly / severe MR
Neural tube defects: defective closure by 4 wks after conception (6 wks EGA). Need folic acid before!
Spina bifida, anencephaly, etc. Elevated AFP
Spina bifida: see lemon sign (concave frontal bones), banana sign (curved cerebellum) on U/S.
Cardiac defects: follow with fetal echo, get peds cards on board. Week 3 (wk 5 EGA) is key time.
VSD: failure of ventricular walls to form
TetFal: overriding aorta, pulmonary stenosis, RV hypertrophy, VSD
Transposition of the great arteries (PA/ Ao into wrong vent)
Coarctation of the aorta: generally preductal if congenital
PDA Eisenmenger syndrome
Hypoplastic left heart: worst outcome with surgery.
Potter sequence: renal failure anhydramnios pulmonary hypoplasia / contractures.
From bilateral renal agenesis, but also if posterior urethral valves / extrophy with obstruction / etc.
Embryology:
Pronephros degenerates.
Mesonephros (Wolffian duct) gives off [ureteric bud urinary collecting system
(tubules, calyces, renal pelvis, ureter)], then degenerates in females, turns into vas /
epidydimis / ejaculatory duct / seminal vesicles if T around in guys.
Metanephros kidney
Paramesonephric duct (Mullerian) Fallopian tubes, uterus, cervix, upper 1/3 of vagina
Fetal anemia: If Rh isoimmunization, hydrops, other concerns for anemia, get PUBS (can get Hct /
transfuse too if needed!)
Normal L&D
Report to the hospital for suspected labor if any of these:
contractions every five minutes for one hour
rupture of membranes
fetal movement less than 10 per two hours
vaginal bleeding.
Breech presentation a/w prematurity, multiples, genetic disorders, polyhydramnios, hydrocephaly, anencephaly,
uterine abnormalities, uterine fibroids. ?oligohydramnios (Williams says it is, uWise says it isnt)
Normal ROM: < 1h prior to onset of labor (>1h = PROM, >18h = prolonged PROM, if < 37wks = PPROM)
Pool, nitrazine (amniotic fluid = alkaline), ferning tests to r/o ROM. Cervical mucus = false + fern
Oligohydramnios in absence of other findings may suggest ROM too.
If really need dx, can inject indigo carmine into amniotic sac look for blue staining of tampon
Bishop score: measure cervical dilation, effacement, station (0-3) and consistency, position (0-2).
Bishop > 8 = favorable for spontaneous labor / induced labor.
0
Position
Posterior
Intermediate
Anterior
Consistency
Firm
Intermediate
Soft
Effacement
0-30%
31-50%
51-80%
>80%
Dilation
0 cm
12 cm
34 cm
>5 cm
Fetal station
-3
-2
-1, 0
+1, +2
Should have at least 1 cm / hr if nullip, 1.2cm / hr if multip (but usually 2-3 cm/hr)
If below these guidelines, calculate MVU
Active phase arrest if no change in dilation or station x 2h with >200 MVU ctx
Stage 2: complete dilation baby time
Can last 1h if multip, 2h if nullip, and you get a bonus hour if you get an epidural
Lac repair: first degree = superficial, 2nd degree = into perineum, 3rd degree = into sphincter, 4th
degree = into rectum.
Stage 3: baby time placenta time
Retained placenta if > 30m; need to extract manually or curretage if fails (may be 2/2 accreta!)
Stage 4 is technically the name of the immediate postpartum period (not the recovery period)
SVD procedures
Operative vaginal delivery: need complete cervical dilation, head engagement vtx presentation, clinical
assessment of fetal size / maternal pelvis, known position of fetal head, adequate maternal pain control,
and ROM - then can use vacuum / forceps if 2nd stage lasting too long.
If baby needs to come out (e.g. FHR dropping), do operative delivery if crowning / really far down.
Pudendal block if no epidural in place
Episiotomy: midline has easier repair, less pain, less blood loss but more 3rd/4th degree tears than
mediolateral (and for spontaneous delivery without episiotomy!)
No role for routine episiotomy / prophylactic these days.
May use to enlarge vaginal outlet if instruments needed, or if descent arrests
C/Section:
Indications: breech, transverse, shoulder presentations; placenta previa / abruption, fetal intolerance of
labor, nonreassuring fetal status, cord prolapse, prolonged 2nd stage, failed operative vaginal delivery,
active herpes lesions, HIV with VL > 1000, etc. Also multiple prior C/S.
TOLAC: need to have < 1-2 previous C/S, low transverse or low vertical incision without extension into
cervix or upper uterine segment. rupture (pop, decrease in IUPC pressure, FHR decels / brady, abd pain)
to OR immediately!
Antepartum Hemorrhage
DDx: Placenta previa, accreta/increta/percreta, placental abruption, vasa previa / fetal cord rupture
Previa: classically painless vaginal sentinel bleed after 28 wks (3rd trim), but nowadays mostly dx on u/s
Placenta often will move up (repeat u/s in 3rd trimester as lower uterine segment develops)
More common in multiple gestations, hx previa, uterine scars
Vaginal exam contraindicated!
In pregnant pt with 3rd trimester vaginal bleeding, r/o with u/s before digitalizing.
Tx: varies generally pelvic rest, esp after sentinel bleed; hospitalize if Hct drops 3pts, etc.
immediate C/S if unstoppable labor, fetal distress, life-threatening hemorrhage. Stabilize, ABCs,
type & cross, 2x large bore IVs, then kleihauer-Betke RhoGAM
If make it to 36 wks, often will amnio for fetal lung maturity C/S between 36-37 wks
Accreta: usually asymptomatic. Consider if previous C/s and low lying anterior placenta, for instance. Big
problem!
Accreta = abnormal attachment into endometrium; increta = into myometrium, percreta = through to
serosa
Abruption: can be concealed or revealed / external;
classic hx painful 3rd trim vaginal bleeding a/w strong abdominal pain and/or frequent, strong ctx. 30%
are asx, however. Often have firm, tender uterus on exam. If abrupting during C/S, see Couvalaire
uterus (if bleeding dissecting into myometrium, uterus is blue/mottled)
U/S not great for dx: only 2% have retroplacental clot, but usually use U/S to R/O previa
Tx: stabilize, type & cross, 2 large bore IVs, etc.
Uterine rupture: rare. Sudden intense abd pain, vaginal bleeding, nonreassuring fetal testing, FHT disappear,
placental part regresses, IUPC low pressure. Immediate laparotomy & delivery of fetus, then repair!
Fetal cord rupture
Velamentous cord insertion: insert between amnion / chorion away from placenta; vulnerable to
rupture. Vasa previa if cross over the internal os (can tear during delivery or ROM)
Succinuriate placenta (extra lobe with vessels going between the lobes) - also can have vasa previa /
rupture from unprotected cords
Often p/w rupture vaginal bleeding, sinusoidal FHR (anemic).
Can dx a fetal source of blood with Apt test (dilute blood, add 1% NaOH, pink = fetal, yellow/brown =
maternal) or microscopy nucleated fetal RBCs.
Tx: emergent C/S (fetus doesnt have much blood to lose!)
L&D Complications
Preterm labor: labor before 37 wks; preterm ctx / pain (vs cervical insufficiency).
High risk of small baby (IUGR, SGA = small for gestational age, whereas LBW = < 2500 g)
A/w PROM, chorio, multiple gestations, uterine anomalies, previous preterm delivery, small mom,
abruption, PEC / maternal infection, surgery, low SES
Preterm labor and a fever- need to do amniocentesis to rule out chorio before giving steroids for lung
maturity
Preterm contractions: dont do tocolysis unless theres cervical change (no labor unless the cervix is
changing). Instead, observe.
Tocolysis: Trying to buy yourself 48h for betamethasone if < 34 wks for lung maturity.
Class
Examples
Notes
Beta-mimetics
Ritodrine*
Terbutaline
No evidence that it
actually delays anything
Ca+ antagonist
Mag sulfate
Ca-channel
blockers
Prostaglandin
inhibitors
Nifedipine
Indomethacin
Antibiotics can prolong latency up to 5-7 days, so give ampicillin +/- erythromycin
Tocolysis - consider if < 34 wks (controversial in pprom esp without ptl)
Corticosteroids - consider if prior to 32 weeks usually
If at 36 weeks or so, just induce
Malpresentation:
CPD and even macrosomia can try TOL but if failure to progress C/S!
Breech: frank = feet up by head, complete = feet indian style, footling = one foot extended.
Dx by U/S, Leopolds, etc.
Can try ECV after 36-37 wks (spontaneous version would happen before); if fails, may retry @
39wks under epidural anesthesia
Trial of breech vaginal delivery - not so much in the USA. Definitely cant try if nullip, incomplete
breech, EFW > 3,800
C/S is prettty much what happens.
VTX malpresentation
Face: if mentum anterior, may be able to do vaginal delivery; o/w must rotate, careful with
augmentation (pressure edema)
Brow: unless preterm & really small head, must convert to vtx or face to deliver
Shoulder: unless conversion, go for C/S (high risk cord prolapse, rupture, difficult delivery)
Compound:(extremity along with vtx or breech): cord prolapse risk! Can try to reduce, but careful
Persistent LOT / ROT or OP - may need operative vaginal delivery or manual rotation
Shoulder dystocia:
risk increases with fetal macrosomia, cDM/gDM, previous shoulder, obesity, postterm, prolonged 2nd stage
complications: Erb palsy / brachial plexus injury, humerus / clavicle fx, phrenic nerve palsy, hypoxic brain
injury, death.
Dx: turtle sign after prolonged crowning of head
Management: McRoberts / suprapubic pressure, call peds, Rubin (push shoulder across fetal chest),
Woods corckscrew (sweep behind post shoulder rotate, dislodge ant shoulder), deliver posterior arm
/ shoulder.
If that fails, then crazy stuff considered: break fetal clavicle, symphysiotomy, or Zavanelli (shove babys
head back inside & head for the OR!)
Maternal hypotension ddx: vasovagal, regional anesthesia, overtx with antiHTN drugs, hemorrhage, anaphylaxis,
amniotic fluid embolism (high mortality, find fetal cells in pulmonary vasculature at autopsy)
Seizures on L&D: ABCs, assess FHR, then Mag Sulfate bolus lorazepam phenytoin phenobarb
IUGR: generally asymmetric (not enough nutrients getting across), a/w smoking
antiphospholipid Ab, SLE, malnutrition, severe chronic renal dz, HTN, anemia in mom, or
placental insufficiency (previa / marginal insertion / thrombosis +/- infarction), or multiples
Big risk shoulder dystocia, brachial plexus injuries, low Apgars, hypoglycemia,
polycythemia, hypoCa, jaundice; also childhood leukemia, Wilms tumor, osteosarcoma
Fetal demise & multiples: if one baby dies in utero, check fibrinogen level qweek / biweekly, esp if
unusual bleeding (fibrinogen may decrease coagulopathy!)
Spalding sign - overlapping of fetal skull bones suggesting fetal demise
Tx: D&E if early, or induction of labor (prostaglandins / high dose oxytocin) if late.
Test for TORCH, fetal karyotype, screen for collagen vascular dz / coagulopathies, get fetal autopsy
Postterm pregnancy: > 42 wks. Get a nst at 40 and 41 weeks - don't just send home!
Higher risk to mom & baby (macrosomia, oligo, meconium aspiration, intrauterine demise, dysmaturity
syndrome - look like old man!)
#1 cause is inaccurate dating.
Manage with more frequent visits, fetal testing (NST in wk 40, BPP & NST in 2 visits in wk 41).
Induce if nonreassuring testing or electively if Bishop > 6 wks 40-41; or no matter what > 42
Multiples: higher risk preterm delivery, congenital abnormalities, SGA, malpresentation.
Twins: usually wks 36-37, triplets: usually wks 33-34. Push up testing too!
Twin delivery: Can do TOL if vtx/vtx or vtx/breech if twins concordant / presenting twin is
larger & vtx (grab smaller second twin & pull out breech!)
Triplet delivery: only if vtx/vtx/vtx (rare), usually C/S. Also C/S for more than 3.
Dizygotic twins: 2 ova, 2 sperm. increased FSH can be hereditary, so dizygotic twins can be too
Monozygotic twins: division of fertilized egg.
DiDi if divides on days 1-3, MoDi if 4-8, MoMo if 8-13, conjoined if 13-15
All dizygotic twins are DiDi (dichorionic / diamniotic), monozy twins can be whatever
DiDi: best outcomes. See twin peak sign later in pregnancy
MoDi twins: see two amniotic sacs, one chorion early on U/S. Risk TTTS
MoMo: risk conjoinment, fetal death 2/2 cord entanglement, etc.
Can consider selective reduction if triplets or above
Twin-twin transfusion syndrome (TTTS, aka poly-oli sequence)
One small, oligohydramnios, growth restriction, anemia twin (donor), large, plethoric,
hypervolemic, cardiac failure, polyhydramnios polycythemic / hydropic twin (recipient)
Dx with ultrasound, historically managed with serial amnioreduction, but now laser coagulation
of artery by fetal surgeons improves outcomes.
Mild Preeclampsia
Risk factors: cHTN, renal dz, also nullip, young or old mom, hx PEC with same dad, living with dad < 1yr
BP 140/90 x 2 and proteinuria > 300 mg / 24h (roughly 2+) and nondependent edema (face/hands)
Can get urine protein/Cr ratio, although not official, for spot check
Contraindications to expectant management remote from term (<32 wks): thrombocytopenia (plt <
100,000), inability to control BP with max doses of 2 antiHTN meds, non-reassuring fetal survellance,
LFTs > 2x ULN, eclampsia, persistent CNS sx, oliguria - need to deliver now!
Tx: Mag sulfate during L&D stay, and 12-24h after. Mag levels (mEq/L):
4-7: therapeutic
7-10: lose DTRs
> 12: respiratory depression
>15: cardiac arrest
If overdose, give calcium (CaCl / Ca gluconate) for cardiac protection
Severe PEC:
> 160 systolic or 110 diastolic x 2 occasions 6h apart; proteinuria > 5g/24h
Can have mild PEC by BP / proteinuria but becomes severe if altered consciousness, H/A or visual
changes, epigastric / RUQ pain, impaired liver fxn (2x nL), oliguria (<400mL/24h), pulmonary
edema, thrombocytopenia (<100)
Tx: need to deliver immediately if > 32 wks or mother crashing. If you can wait, try BMZ & check lung
maturity. Delivery is the cure
Eclampsia: see seizures in L&D above.
ABCs, stabilize mom; Mag sulfate lorazepam phenytoin phenobarb; Lower HTN with hydralazine
Deliver only when mom has stopped seizing (best for fetus too)
HELLP syndrome:
Dx: rapidly deteriorating liver fxn (AST/ALT increases), thrombocytopenia < 100, hemolysis
(schistocytes on peripheral smear, elevated LDH, elevated total bili)
Sx:RUQ pain (liver capsule distention), nausea, vomiting can lead to hepatic rupture!
Acute fatty liver of pregnancy (AFLP): vs HELLP, see elevated ammonia, hypoglycemia (glc < 50), reduced
clotting factors (fibrinogen & antithrombin III) in AFLP (fulminant liver failure!)
Diabetes in pregnancy
GDM: related to hPL, diabetogenic hormone
Not a/w congenital anomalies like pregestational DM (shows up in late 2nd / early 3rd trimester)
But do have incr risk neonatal hypoglycemia, hypoCa, hyperbili, polycythemia; risk of maternal T2DM later
Screen between 24-28 wks as described above. 50g 1h GLT 100g 3h OGTT.
White Classification: GDM A1 = diet controlled, A2 = needs meds / insulin.
B-->D-->C for duration. F=neFropathy, R=Retinopathy, H=Heart dz, T=prior renal Transplant
A2 (not A1) pts: NST or mod BPP starting between 32-36 wks; U/S for EFW between 34-37 wks.
Treat with CHO restricted diet, exercise to enhance postprandial blood sugar control (biggest time in
gDM)
Pregestational DM
Risk factor for mom: PEC/eclampsia, SAB, infection, polyhydramnios, PP hemorrhage, C/S
Infants of diabetic mothers
Including gestational DM - higher risk for hypoglycemia, respiratory distress, polycythemia,
hyperbili, hypoCa
Pregestational specifically: if really high HbA1c, think congenital defects (cardiac most common;
also renal / NTD / pretty much all systems. Caudal regression syndrome / sacral agenesis
classic 2/2 disproportionally high risk in poorly controlled diabetics, but not as common as others).
Get HbA1c at outset to see status; then follow closely; good control prior to pregnancy key
Also should get 4mg folate daily (higher risk of NTD).
Diet/exercise meds / insulin as needed!
If poor control (T2 or T1): Should get ECG (esp if HTN), HbA1c, optho consult, etc.
If insulin dependent, offer fetal lung maturity @ 37 wks or IOL @ 38-39wks without testing
Type 1 DM : Prepregnancy control key. Pumps are good. Dont mess with insulin regimen until needed.
Type 2 DM: made worse by pregnancy, may go from diet/exercise or oral meds insulin needs (manage as above)
Fetal testing @ 32 wks, earlier if poor control. Weekly NST / modified BPP for AFI.
Get growth U/S @ 32-36 wks
Chorioamnionitis
Sx: maternal fever, elevated WBC in mom, fundal tenderness, fetal tachycardia.
Can be fooled: elevated T from prostaglandins, tachycardia from terbutaline, WBC elevated in
pregnancy & with labor, or with corticosteroids!
Fundal tenderness + PPROM = chorio until proven otherwise
Do amnio, give IV antibiotics, then speed up delivery time!
On amnio, see high IL6 and low glucose. WBC not a good marker.
Induce / augment if mom & fetus stable, C/S if not
VZV: 90% adults immune. Cant vaccinate in pregnancy (live vaccine), but can do before / after
Transplacental spread, a/w congenital malformations (congenital varicella syndrome) if early infection,
or postnatal infection (anywhere from benign disseminated & death) if late in preg
Give VZIG to mom within 96h if no hx chickenpox and exposed during pregnancy (lessens her outbreak,
but doesnt decrease risk transmission to fetus)
Give VZIG to infant if mom has outbreak within 5d before - 2d after delivery
Note: maternal zoster not a/w congenital anomalies
Parvovirus B19: causes erythema infectiosum (fifth dz) - mild infection, red macular slapped cheek rash
Outbreaks in elementary schools, etc. Mild in kids / adults usually
In pregnancy: 1st tri a/w miscarriage, 2nd tri a/w fetal hydrops (attacks fetal erythrocytes hemolytic
anemia, hydrops, death)
If suspected exposure, check parvovirus IgM/IgG. If IgM +, think acute infection. If after 20 wks and acute
infection put baby on anemia protocol (serial U/S, MCA dopplers, PUBS / transfuse if hydrops)
CMV: subclinical / mild viral illness in mom, rarely hepatitis / mono-type picture (rarely diagnosed)
In baby: 10% exposed develop CMV inclusion disease (hepatosplenomeg, thrombocytopenia,
jaundice, cerebral calcs, chorioretinitis, interstital pneumonitis, also MR, high mortality,
sensorineural hearing loss). No tx or PPx available.
Rubella: mom gets mild illness, maculopapular rash, arthralgias, diffuse LAD x 2-4 d
Congenital rubella syndrome in baby, esp high transmission in 1st trimester
Deafness, cardiac anomalies, cataracts, MR. blueberry muffin baby.
Dx with IgM titers. No tx available if acquired.
Mom cant get MMR in pregnancy (live vaccine)
HIV: get viral load suppressed with HAART, AZT=ZDV intrapartum and afterwards to baby to decrease trans.
Do a C/S if VL > 1,000; otherwise can have vaginal or C/S.
Should bottle feed
Gonorrhea:
Screen in pregnant women @ prenatal visit, again in 3rd trim if at risk, with NAAT or cx
Treat: IM ceftriaxone, oral cefixime. Also tx with azithromycin / amoxicillin for chlamydia too
Causes PID only in early pregnancy. A/w preterm delivery, PPROM, other infections.
Neonate: mucosal surfaces affected (eyes, oropharynx, external ear, anoretal mucosa). Can also be
disseminated (arthritis, meningitis)
Chlamydia: transmitted in labor. PNA is the big complication. Often asx, so screen as for GC.
Remember, no tetracycline / doxy in pregnancy, so give azithromycin, amox, or erythromycin
HBV: from sex, blood exposure. Transplacental transmission; can lead to fulminant liver failure, etc.
Screen everybody for HBsAg. If positive, give HBIg / HBV vax for baby after delivery.
Syphillis: T. pallidum, transmitted transplacentally; usually primary or secondary syph (need spirochetes)
Vertical trans: intrauterine fetal demise, late abortion, or congenital syndrome (maculopapular rash,
snuffles, hepatosplenomeg, hemolysis, jaundice, LAD). Dx with IgM antitreponemal ab (remember,
IgM dont cross placenta, so if baby has em theyre infected)
PCN is the only treatment - desensitize and treat with PCN if allergic!!
Later manifestations: CN VIII deafness, saber shins, mulberry molar, saddle nose, Hutchinsons teeth.
Toxoplasma gondii: protazoa, generally subclinical unless immunocompromised , may have vague viral illness
Vertical trans is transplacenta, highest if third trimester acquisition. Stay away from cat feces
Neonate: fevers, seizures, chorioretinitis, hepatosplenomegaly, jaundice, hydro / microcephaly.
Dx with IgM in neonate, or DNA PCR via amnio to guide decision to terminate.
Can treat mom with spiramycin (no teratogenic effects known), but doesnt cross placenta no effect on
baby. So use pyrimethamine / sulfadiazine along with folate to prevent bone marrow suppression if
fetal infection has been documented.
Maternal renal disease: pregnancy can make it worse; higher risk PEC.
Screen qtrimester with 24h urine for Cr/prot; antenatal testing from 32-34 wks onward.
If s/p transplant, may need to increase meds to avoid rejection (higher Vd)
Maternal coagulopathies
Pregnancy extra coagulable. mechanism not precisely known.
Higher risk pelvic vain thrombus 2/2 IVC compression).
Superficial vein thrombosis: painful, visible venous cord. Rx warm compress / analgesic (wont cause
PE) and watch for si / sx of DVT/PE
DVT: treat with IV heparin subQ heparin for rest of pregnancy.
No coumadin nasal hypoplasia, skeletal problems
PE: get EKG, spiral CT. Rx IV heparin subQ heparin / LMW heparin
Will switch to unfractionated heparin @ 36 wks - shorter half life, so can d/c if presents to L&D
Can switch to Coumadin x 6mo postpartum
If unstable / massive, consider tPA / thrombectomy
Maternal thyroid disease
Graves disease: tx with PTU or MMI (depends on practitioner, PTU is classic but more using MMI now)
Hashimotos: levothyroxine.
SLE:
Early pregnancy: high risk loss in 1st/2nd trimester 2/2 placental thrombosis, esp if antiphospholipid Ab
Later pregnancy: also can lose 2/2 thrombosis. Antenatal testing @ 32wks onwards. Higher risk PEC
Lupus flares: can look like PEC, but have low complement.
If flaring, try high dose steroids cyclophosphamide if that doesnt work. If PEC, deliver.
Neonatal problems: can get irreversible congenital heart block 2/2 anti-Ro (and anti-La, but more Ro)
antibodies which cross-react with fetal cardiac conduction system.
Screen for anti-Ro at first visit; interventions vary.
Substance abuse:
Alcohol: FAS possible with > 2-5 drinks / day. Growth retardation, CNS effects, abnormal facies, cardiac
defects, etc. If in withdrawal, try barbituates instead of benzos (less teratogenic)
Caffeine: > 1 cup coffee (150 mg) may increase miscarriages
Cigarettes: a/w SAB, preterm birth, placental abruption, LBW risk, also higher risk SIDS. Stop!
Cocaine: a/w placental abruption, IUGR, preterm birth.
Opiates: heroin, methadone most common. No teratogenicity. Risk is with withdrawal put on NAS
protocol with tincture of opium, etc for baby.
Other stuff:
Asthma in pregnancy: chronic tx: short-acting beta agonists, then inhaled corticosteroids or cromolyn,
then theophylline. acute tx: subq terbutaline, systemic corticosteroids.
Pruritis gravidarum: mild variant of intrahepatic cholestasis of pregnancy; retain bile salt dermis
deposits pruritis; use antihistamines / topical emollients initially, then can try cholestyramine
ursodeoxycholic acid if really bad.
If appendicitis suspected, get a graded compression ultrasound (best for eval - CT has lots of radiation)
Depression: Paxil is class D (increased risk fetal cardiac malformations & persistent pulmonary HTN)
0 points
1 point
2 points
Activity
(Muscle tone)
limp
limbs flexed
active movement
Pulse
(heart rate)
absent
Grimace
(response to smell or foot
slap)
absent
grimace
Appearance
(color)
blue
body pink
extremities blue
Respiration
(breathing)
absent
irregular
weak crying
If bleeding wont stop in OR, can try B-lynch sutures to compress, then may start having to tie off bigger
vessels
DDx:
vaginal lacs / hematomas, cervical lacs (fix),
uterine atony (everybody gets Pit ppx postpartum, uterotonics below),
retained POC (examine / may need D&C),
accreta,
rupture (rare),
inversion (too uch cord traction; need to replace manually; if not GETA laparotomy).
Uterotonics - route of administration
Oxytocin is administered as a rapid infusion of a dilute solution (20-80 units in a liter) and not as
an IV bolus.
Prostaglandin F2 should be administered intramuscularly. It could also be injected directly into
the uterine muscle.
Neither prostaglandin F2 nor methylergonovine should ever be administered IV, as they can
lead to severe bronchoconstriction and stroke, respectively.
Uterotonics: contraindications
Methylergotavine (methergine) - hypertension & preeclampsia (constricts smooth muscle and
exacerbates HTN)
Hemeabate (prostaglandin f2) - asthma (bronchoconstrictor)
Endomyometritis
Polymicrobial infection, more common after C/S, higher risk if chorio / meconium / prolonged ROM
Si/Sx: fever, high WBC, uterine tenderness, esp 5-10d after delivery but can be several weeks
Workup: r/o retained POC with U/S. If retained POC, do blunt curettage (PP uterus can rupture!)
Rx: broad spectrum IV abx until afebrile x 48h, no uterine pain / tenderness, normal WBC
Breastfeeding
To suppress lactation: breast binders, ice packs, analgesics, avoid nipple stimulation (not bromocriptine
or other meds which can cause rebound engorgement and thromboembolic events!)
Breastfeeding candidiasis: onset of pain in breast when feeding, sore / sensitive nipples. Exam: pink
shiny nipples with peripheral peeling.
Signs that a baby is getting sufficient milk: 3-4 stools in 24 hours, 6 wet diapers in 24 hours, weight gain
and sounds of swallowing.
Breast engorgement? Try feeding more often, taking showers, NSAIDs before feeding. Can actually lead to
fever (low grade, with breast engorged and/or hx of trouble breastfeeding)
Prolactin causes milk production, oxytocin causes milk letdown
Progesterone-only contraceptives are best in puerperium (dont interfere with milk let-down) - like Depo
Other Postpartum Stuff
Postpartum depression if longer than 2 weeks, ambivalence towards newborn, etc. (vs blues)
Can use SSRIs, safe for breastfeeding.
Postpartum fever ddx
Endometritis - uterine tenderness, hx of d&c or c/s, fever and tachycardia. See above.
Mastitis: fever, elevated WBC, focal tenderness & erythema, one breast warmer.
Admit if no response to abx in 48h; suspect breast abscess & get imaging.
Breast engorgement
Septic thrombophlebitis - absence of other findings, no uterine tenderness but just a fever
without other signs. May be able to dx on lower extremity / pelvic ct - involves pelvic veins. Rx
abx and anticoagulants.
Gynecology
Benign Lower Genital Tract Disorders
Congenital anomalies
Labial fusion: 2/2 exogenous androgens or CAH (21-hydroxylase deficiency) - check 17-OH progest
If CAH, treat with cortisol (suppresses ACTH inhibits adrenal activity less androgens). If saltwasting, give mineralocorticoids back too (fludrocortisone). Surgery to reconstruct
Imperforate hymen: buildup of secretions (hydrocolpos / mucocolpos) in vagina, primary amenorrhea
+ cyclic pelvic pain at puberty. Surgery.
Transverse vaginal septum: 2/2 incomplete canualization between mullerian upper vagina & urogenital
sinus-derived lower vagina. Can present like imperforate hymen, but exam shows short vagina with blind
pouch U/S & MRI show upper vagina & uterus. Surgery.
Vaginal atresia: lower vagina (from urogenital sinus) fails to develop. Primary amenorrhea, cyclic pelvic
pain too - but no introitus (vaginal dimple) instead; confirm dx with U/S or MRI, then surgery (e.g.
vaginal pull-throguh)
Vaginal agenesis = mullerian agenesis = mayer-rokitanksy-kuster-hauser syndrome.
Congenital absence of vagina as well as hypoplasia or absence of cervix, uterus, fallopian tubes.
Normal external genitalia & secondary sex characteristics (normal ovaries), 46,XX.
Primary amenorrhea in adolescence. Dx on U/S or MRI.
Can create neovagina with surgery (McIndoe - buttock skin graft reconstructed) or serial dilators
(Frank/Ingram). Clearly, cant carry pregnancy w/o uterus (but can use surrogate with her eggs)
Epithelial disoders of vulva / vagina
bx all vulvar lesions! If vaginal, bx via colpo
For tx, avoid tight-fitting clothes, bubble baths, douching, etc.
Physical findings
Symptoms
Treatment
Lichen sclerosis
Squamous cell
hyperplasia
Chronic pruritis,
thickened skin
Lichen simplex
chronicus
Pruritis, often
worse @ night
Vulvar psoriasis
Vaginal adenosis
Asymptomatic
A/w DES exposure
in utero.
Lichen planus
Vaginal hydrocortisone
suppositories; may need surgery /
dilators for adhesions.
If postmenopausal, estrogen for
atrophy.
Vulvar vestibulitis - constellation of sx including severe pain on vestibular touch or attempted vaginal
entry, tenderness to pressure and erythema of various degrees, often sudden onset, sharp / rawness in
nature. Vulva / vestibule only. can be worsened when biking, tight shorts, tampon insertion, etc.
Tx - tricyclic antidepressants to block sympathetic afferent pain loops, pelvic floor
rehabilitation, biofeedback, and topical anesthetics. Surgery with vestibulectomy is
recommended for patients who do not respond to standard therapies and are unable to tolerate
intercourse.
Cysts, etc:
Epidermal inclusion cysts on vulva: Usually go away, I&D if superinfected
Sebacous cysts: same as above, just accumulating sebum
Apocrine sweat gland cysts - can be occluded, abscesses hidradenitis supperativa if multiple abscesses
form. Excise or I&D; give abx if cellulitis
Skenes gland cyst (near urethral meatus) Bartholins duct cyst - B=below introitus.
If small (1-2 cm), watch and/or sitz bath
If bigger / symptomatic, can I&D & place Word catheter x 4-6 wks
If woman over 40, biopsy to r/o rare bartholins gland carcinoma
If recurrent, can marsupialize (suture cyst wall to vaginal mucosa to prevent reforming)
If abscess (infected looking), only treat if N. gonorrhea isolated, otherwise I&D sufficient.
Congenital: can see double cervix = bicollis if 2 uteri or other anomalies 2/2 in utero DES exposure
(higher risk of clear cell adenocarcinoma of cervix / vagina).
Cysts on cervix
retention = nabothian from blockage of endocervical gland, usually asx, no tx needed
mesonephric (from wolffian ducts), or endometrial implants too
Cervical polyps: pedunculated or broad based. Usually asx but can be a/w spotting.
Not premalignant, but remove - can mask irregular bleeding from other source!
Cervical fibroids: can cause intermenstrual bleeding, dyspareunia, bladder / rectal pressure, L&D
problems. Remove as possible.
Ovarian cysts
Functional - normal functioning cysts
Follicular = most common. From failure of follicle to rupture. 3-8cm. Asx, unilateral but can be
tender. Higher risk of torsion if greater than 4-5 cm. Resolve in 60-90d
Corpus luteum cyst: when corpus luteum fails to regress after 14d, or enlarges, or becomes
hemorrhagic. Can delay menses / cause unilateral lower quadrant pain. Can rupture
hemoperitoneum. Feel more firm on exam.
Theca lutein cysts - large, bilateral cysts, clear, straw-colored fluid. From stimulation by abnormally
high B-hCG (molar pregnancy, choriocarcinoma, ovarian induction therapy)
Warning signs:
Ovarian torsion: classically waxing / waning pain & nausea. Concern if > 4cm
If premenarchal or postmenopausal, think neoplasm & do ex-lap
If persist > 60 days, are solid or complex on U/S, or larger than 8 cm in reproductive woman,
think neoplasm diagnostic laparoscopy or laparotomy.
Follow up with pelvic ultrasounds serially to check for cyst resolution;
CA-125 if concerned for cancer
Start patients on oral contraceptives during observation period (to prevent future cysts)
Cystectomy / evaluation via laparoscopy / laparotomy if no resolution in 60-90d
Endometriosis / Adenomyosis
Endometriosis: Endometrial glands / stroma outside of endometrial cavity
endometrioma = cystic collection in ovary (chocolate cyst)
Severity of sx doesnt correlate with amount of endometriosis
Dx: really need surgical confirmation by direct visualization
Sx: cyclic pelvic pain starting 1-2 wks before menses, peaking 1-2d prior to menses, then subsiding
Also dysmenorhea, dyspareunia, abnl bleeding, infertility
Tx:
expectant management if minimal sx or trying to conceive
medical: suppress / atrophy endometrial tissue
Follow RPR / VRDL titers - should see decrease @ 6mo, nonreactive @ 12-24mo
Jarisch-herxheimer rxn: from death of spirochetes; after starting PCN, fever, chills, H/A, myalgia,
malaise, pharyngitis, rash w/in 24h. Shouldnt prevent / delay therapy
HSV:
If pregnant, C/S
Chancroid (H. ducreyi).
Painful, well-demarcated, non-indurated ulcer with painful supperative inguinal LAD
Very rare in USA.
Dx with culture (chocolate agar), hard to do.
Tx with ceftriaxone IM x1, azithro PO x 1, or longer cipro / erythro regimens. treat partners too
LGV (C. trach L1-3)
First stage: painless, transient local lesion (papule / ulcer) Secondary stage: inguinal
syndrome (painful enlargment / inflammation of inguinal nodes, fever / H/A / malaise, anorexia)
Tertiary stage: anogenital syndrome (proctocolitis, rectal stricture, rectovaginal stricture,
elephantiasis.
Dx: clinical suspicion, can also use cx / immunofluorescence / NAAT
Rx: doxycycline 100 mg PO BID or erithroymycin x 21 days.
Non-ulcerated lesions
Condyloma acuminata (genital warts) - caused by HPV
Raised papillomatous wart can grow to large pedunculated lesions. Bx if uncertain
Prevent with gardasil.
GC/CT are most common, but also anaerobes, E. coli, H. flu, gardnerella, strep
Definitive dx with laparoscopy / pelvic imaging with PID findigns / endometrial bx
Tx: hospitalize (esp if teenagers, nullips, noncompliant), get fluid status under control
IV abx: broad spectrum cephalosporin (e.g. cefoxitin) and doxycycline (for atypicals)
After 24h afebrile, can d/c IV abx but continue doxy. If allergic, can use clinda + gent
For o/p tx, ceftriaxone IM x1 + PO doxy +/- metronidazole x 14d
1st degree = structure in upper of vagina; 2nd degree = to level of introitus, 3rd degree= outside of
vagina, 4th degree = whole structure outside of vagina. POP-q can quantify more precisely.
Bigger problem in post-menopausal women 2/2 decreased estrogen, more vaginal deliveries.
Also increased risk with chronic increased abdominal pressure (chronic cough, constipation,
repeated heavy lifting, large pelvic tumors).
Do a split-speculum exam. May also need urine cx, cystoscopy, urethroscopy, urinary studies,
anoscopy, sigmoidoscopy, defecography depending on presentation.
Whats prolapsing?
Anterior
Cystocele, urethrocele
Posterior
Rectocele, enterocele
Top
Uterus
Anywhere
(collapsing after
hysterectomy)
Urinary Incontinence
Nerves: CNS inhibits; parasympathetic pelvic nerve from S2-S4 helps urinate, as does somatic pudendal nerve.
Workup:
Voiding diary (when are you leaking?)
Do U/A and UCx to r/o infection
Can get urodynamics, PVR, etc.
Standing stress test: stand over towel & cough.
Type
Dx
Etiology
Notes / Tx
Start with behavior /biofeedback / training / Kegels /
pessaries / etc, but may need to go to surgery:
Stress
Sx on exertion or
straining (cough /
laugh / exercise)
Cotton swab test for
hypermobile urethra
Urge
Involuntary urine
loss with sudden
urgency whether or
not bladder is full;
frequency & nocturia
Mixed
Mixed symptoms of
above
Detrusor overactivity
Most is idiopathic; also
with CNS injury
Overflow
Frequent / constant
dribbling, also stress /
urge incontinence.
Meds:
Reduce urethral closing pressure (prazosin,
terazosin, phenoxybenzamine)
Striated muscle relaxants (diazepam, dantrolene)
Cholinergic agents (bethanecol) to increase
contractility
Intermittent self-cathing used too.
Bypass
Dx with indigo
carmine instilled into
bladder, then tampon.
Can use IVP /
cystogram / etc too
Functional
Nursing home,
geriatrics, poor
mobility
Stress incontinence: Use sling if hypermobile & intrinsic sphincteric deficiency combined
Use retropubic urethropexy if stress incontinence for hypermobility alone (sling can be obstructive as
well - higher rate of retention, voiding dysfunction).
Use urethral bulking if stress incontinence for intrinsic sphincteric deficincy alone
Puberty
Adrenarche (zona reticularis in adrenal starts making androgens), then gonadarche (pulsatile GnRH)
Adrenarche: ages 6-8; Gonadarche around age 8
Thelarche (~10 y/o) pubarche (~11) growth spurt peak velocity (9-10) menarche (12-13, or
usually ~2.5yrs after thelarche). Earlier in AA, later in Caucasians / thin girls / etc.
True precocious puberty (due to pulsatile GnRH secretion) - treat with nonpulsatile GnRH
Menopause
Definition: 12 months of amenorrhea after last menstrual period. Avg age 51, but big range.
Perimenopause before that point - can still have periods! Get OCPs, not HRT
Sx: Hot flashes, mood changes, insomnia, dyspareunia. Sx usually disappear w/in 12 mo
Signs: vaginal / cervical atrophy
Decreased estrogen, FSH elevation / LH too, but just supportive (not diagnostic)
Also increased coronary artery disease risk, accelerated bone resorption osteoporosis
Osteoporosis:
Osteoporotic fx hx - can treat with bisphosphonates right away without waiting for dexa results
Osteoporosis risk: consider getting DEXA (everybody @ 65 y/o, or @ 60 y/o if high risk)
Treatment
Bisphosphonates (if pathologic fx of hip or vertebrae, other fx and T-score -1.0 to -2.5, or T
score < -2.5).
Should be taking 1000-1500 mg Ca daily no matter what; if osteoporotic, 800 IU vitD too.
SERMs help with osteoporosis too.
Hormone replacement therapy
Unopposed estrogen endometrial hyperplasia endometrial cancer,
so if still have a uterus, need progestins too
Combined HRT: short period of time (6-12 mo), smallest dose
Helps prevent osteoporosis
Contraindicated if chronic liver dz, pregnant, breast / ovarian / uterine Ca, hx DVT
In WHI, actually more CV-related complications in combined hormonal group.
Irregular vaginal bleeding is a contraindication too - need to get a biopsy first
Can also try SSRIs for flushing / mood sx, but not great; also vaginal estrogen for atrophy / dryness
Resumption of bleeding is the #1 reason that women stop hormone replacement therapy
Amenorrhea
Primary amenorrhea - no menarche by age 16 or 4 years after thelarche
Outflow tract anomalies: imperforate hymen transverse vaginal septum, vaginal atresia
All treated with surgery
Mullerian agenesis = MRKH syndrome - pt with no menses, blind pouch vagina, but normal body hair
get a renal ultrasound to check for other commonly associated abnormalities.
Androgen insensitivity, pt with primary amenorrhea with absence of body hair
Get a karyotype to confirm 46,XY
Do have testes MIF secreted no mullerian structures; blind pouch vagina
Swyer syndrome: 46,XY with congenital absence of testes
NO MIF mullerian structures present, as opposed to AIS
Ovarian failure: see low estrogen but high gonadotropins
Savage syndrome: no LH/FSH response 2/2 receptor defect
Turner syndrome (45,XO) - rapid atresia of ovaries no estrogen
Kallman syndrome - no menses, no secondary sex characteristics, normal external genitalia.
Central disorder - low GnRH low FSH/LH low estrogen (labs look like anorexia, etc)
Dx with olfactory challenge. Tx with pulsatile GnRH
Pt 16 years old or younger - just reassure if no menses yet!
Secondary amenorrhea
Pregnancy is #1 cause!
Anatomic abnormalities:
Asherman syndrome (intrauterine synechiae in pt s/p myomectomy, C/S, D&C, endometritis)
Cervical stenosis 2/2 surgical, obsetric trauma
Premature ovarian failure - often idiopathic, also 2/2 torsion, surgery, infection, radiation, chemo
Symptoms of menopause before age 40; do chromosomes if < 35 y/o
PCOS = Stein-Leventhal syndrome
chronic anovulation, oligomenorrhea / amenorrhea, hirsutism, obesity, enlarged polycystic ovaries
Increased LH:FSH ratio kills follicle, more androgens hirsutism
Treat with OCPs / cyclic progestins / Depo to suppress endometrial hyperplasia / etc
if withdrawal bleeding present, outflow tract is patient & estrogen present in good enough
quantities.
Think anovulation (PCOS, ovarian / adrenal tumors , Cushing syndrome, thyroid disorders,
adult-onset CAH).
If bleeding present now, think not enough estrogen - get LH/FSH levels
If LH/FSH normal or low, think hypothalamus or pituitary
If LH/FSH high, think premature ovarian failure
Adrenal disorders:
Cushing syndrome: Cushing disease if from ACTH-secreting pituitary adenoma; also can be paraneoplastic
or 2/2 adrenal tumor (which would suppress ACTH). Get overnight dexamethasone suppression test
(should decrease endogenous production if normal negative feedback); or 24h urine for cortisol
Congenital adrenal hyperplasia - usually 21alpha-hydroxylase deficiency, causing 17hydroxyprogesterone to build up (gets shunted down androgen pathway). Also dont make cortisol or
mineralocorticoids (adrenal insufficiency - hypotension, etc, and salt wasting); if female, can present with
ambiguous genitalia at birth or have late onset virilization.
Can also be 11-beta hydroxylase (precursor builds up with mineralocorticoid activity, so
hypertensive) or 3B-HSD deficiency too.
Always check 17-OHP level; can confirm with ACTH stim check 17OHP 1h later (big rise =
CAH). Lower elevations can be c/w late-onset CAH or heterozygotes
Can suppress adrenal production with prednisone 5mg qhs
Contraception / Sterilization
Stuff that kind of works
Periodic abstinence (ha!) with ovulation kits, calendars; coitus interruptus, lactational amenorrhea
(but will start to ovulate before return of menstration usually in 6-12 mo)
Stuff that works better
Condoms: 15% failure rate, but protect against STDs
Birth control pills: 8% real life failure rate; decrease ovarian / endometrial cancer, etc. Can get nausea,
h/a, breakthrough bleeding, wt gain
Estrogen and progesterone. Have to remember to take every day
Progesterone only: have to take at same time every day, higher failure rate. Decrease PID risk, OK
for use during nursing as well.
Bleeding every month, every 3 months, or continuous dosing (more breakthrough bleeding)
How to start:
Depo: Progesterone. Shot in arm every 3 months. Can cause irregular bleeding, especially at beginning,
which bothers some people more than others. Also decreased bone density (reversible). can cause
depression, wt gain, hair loss, h/a. Can lead to amenorrhea. May take 6-18mo for fertility to return.
Implanon: 3 years, progestin implant, most women have lighter periods (some none at all), really effective
but can have irregular / unpredictable light bleeding
IUDs: Longer term, very effective
Mirena: progesterone. 5 years. Lighter or no periods.
Paragard: copper. 10 years. Can cause irregular bleeding.
Less common stuff:
patch (not if overwt > 198 lbs or high thromboembolism risk),
nuvaring (3 wks in, 1 wk out, or 3mo in with changes, 1 wk out, 0.8% failure rate),
diaphragm (fit by clinician; leave in place 6-8h after intercourse, risk toxic shock syndrome),
cervical cap (fitted by clinician, use with spermicide can be hard to use),
spermicides (nonoxyl-9, etc, should use with condoms, can irritate mucosa & increase STI
transmission)
Emergency contraception - Plan B (progestin only) within 72h. Need Rx if < 18, OTC if > 18.
Plan B, the levonorgestrel pills can be taken in one or two doses and cause few side effects. Oral
contraceptives need to be taken 12 hours apart if using those.
Can insert second dose of ocps per vagina or take an antiemetic 1 hr before administration
to decrease nausea/vomiting (major side effect
Copper IUD can be put in within 5-8 days, actually the most effective form of emergency
contraception
Sterilization
Tubal ligation
Can be done laparoscopically (clips, cautery, banding)or hysteroscopically (Essure, Adiana);
Can do immediately postpartum through small subumbilical incision
Essure - takes 12 weeks, use backup birth control until HSG confirms complete occlusion
Leads to a slightly decreased risk of ovarian cancer (mechanism unknown)
Age < 30 have highest regret for procedure
Vasectomy:
Not immediately effective! Use alternate contraception until repeat semen analysis in 6-8wks
Simpler, safer, more effective than BTL
Can form antisperm antibodies, but no long-term effects.
Surgical options
Manual vacuum aspiration - more than 99% effective but needs to be 7-8 wks EGA or less
D&C up to 16 wks
D&E after 16 wks - use laminaria first, then introduce large cannula; may need forceps
Used off label as abortifacent (but approved for ectopics) within 49d of LMP
Other stuff:
If tissue needed for karyotype, etc should do medical abortion (mifepristone / misoprostol prior to 49
days, or induction with prostaglandins if 8 0/7 or later).
Make sure to give RhoGAM if Rh negative (at time of termination) - both medical & surgical!
Give abx (doxy, ofloxacin, or ceftriaxone) to prevent postabortion endometritis
Rough guide: termination is legal if < 24 wks (threshold of viability) or later if abnormality incompatible
with life
Letrozole: aromatase inhibitor, decreases peripheral estrogen production more GnRH more LH/FSH
more follicles, etc. Decreases peripheral estrogen (good for fertility in breast cancer pts, etc)
Metformin: insulin sensitizer (biguanide), but some studies suggest it doesnt help in PCOS
Human menopausal gonadotropins: purified FSH/LH, next line after Clomid
Follistatins (Follistim) - recombinant FSH, stimulates follicular development
Recombinant hCG - similar to LH, used to trigger ovulation after follicle stimulation
Pulsatile GnRH - can be used to increase FSH/LH release. Often used for HPA axis failure (e.g. low wt)
Can try surgery too - for endometriosis, or tuboplasty with reanastamosis (although many go straight to
IVF), or uterine factors (cut synechiae, remove polyps, etc)
Try
Clomid
Letrozole
Recombinant GnRH
ICSI
Azoospermia
Donor sperm
Donor egg
Complications:
Multiple gestations
Ovarian hyperstimulation syndrome (OHSS) - ovarian enlargement, can lead to torsion / rupture, can be
complicated by ascites / pleural effusion / hemoconcentration / hypercoagulability / renal failure / even
death
Preimplantation genetic diagnosis: evaluate embryo for genetic abnormalities before implanting into uterus
e.g. for pt with hx of Huntingtons, sickle cell, etc
Preimplantation genetic screening: screen for conditions, usually chromosomal, screening for aneuploidy
e.g. for advanced maternal age, etc.
If younger, can try 5-FU / imiquimod to preserve anatomy, but cant be invasive and need
to follow up closely (lower effectiveness)
Bx the lesions!
Tx: local excision.
If invasion ruled out, can try laser vaporization or 5-FU (esp if multiple lesions or
immunocompromised)
Cervical cancer: 80% SCC, most of rest is adenoCa (think clear cell adenoCa with DES exposure in utero)
High risk serotypes, immunosuppression, etc (cervical cancer = HIV-defining illness)
Dx: usually asx (need to screen with Paps!). Can have postcoital bleeding, see mass on spec exam, etc
Cancer can only be diagnosed with tissue bx, not with Pap!
Staging is clinical (only GYN cancer with clinical staging) - look for invasion to adjacent structures /
metastasis (EUA, CXR, cystoscopy, proctoscopy, IVP, barium enema).
MRI / CT cant be used for staging; also, staging doesnt change based on operative findings
Stage I: confined to cervix
Stage II: beyond cervix but not to lower vagina or pelvic sidewalls
Stage III: to pelvic sidewalls or lower of vagina
Stage IV: beyond pelvis, or into bladder/rectum, or distant mets
Treatment:
If preinvasive / microinvasive (stage I-Ia) simple hysterectomy
Includes parametria, upper vaginal cuff, uterosacral / cardinal ligaments, vascular supply
Endometrial Cancer
#1 common / curable GYN cancer in USA
Risk factors: unopposed estrogen (obesity, chronic anovulation, nullip, late menopause, exogenous
unopposed estrogen, early menarche, tamoxifen use), also HTN / DM, HNPCC, breast Ca hx, BRCA 1
Protective: OCPs, combination HRT, high parity, pregnancy, physical activity, smoking (weird.
Subtypes
Younger women: type I, estrogen-dependent, more favorable prognosis.
Older thin white women: type II, non-estrogen dependent, less favorable
Most are endometriod adenocarcinoma, with complex atypical hyperplasia as precursor
Extension is direct to cervix / outward through myometrium lymphatics eventually; heme less common
Grade is most important prognostic factor
Sx: postmenopausal / abnormal vaginal bleeding. can also see pelvic pain / mass / wt loss if advanced
Dx: endometrial biopsy D&C (if suspicious findings on EMB)
Also get TSH, PRL, FSH as part of w/u; may also get CA-125 (if super high, maybe advanced), Pap
Pelvic U/S (postmenopausal should have endometrial stripe < 4-5mm).
Even if normal endometrial stripe & pelvic U/S, need to get tissue (EMB/D&C)
Staging:
Stage I: Ia limited to myometrium, Ib/c into myometrium
Stage II: cervical invasion
Stage III: into serosa / peritoneum / vagina / pelvic or periaortic LN
Ovarian Tumors
Worry about pelvic mass if >8cm, solid or cystic+solid, nodular, multilocular, + doppler flow, bilateral
3 categories: epithelial, germ cell, or stroma.
Metastatic - usually GI tract (Krukenberg), breast, endometrium
Usually spreads via direct exfoliation; can be lymphatic too, more rarely hematogenous
Epithelial tumors (65-70%)
0-25+ years
All ages
Serous cystadenocarcinoma,
mucinous, endometriod, clear cell,
Brenner, undifferentiated
Type
Differentiation
Notes
Dysgerminoma
No differentiation
(totipotent)
Embryonal
carcinoma
Starting to differentiate
towards one of below
Teratoma
AFP
Differentiation:
Trophoblastic (placental)
Differentiation:
Embryonic (fetal)
Marker
hCG
Benign cystic mature teratoma = dermoid cyst = most
common germ cell tumor! Cystic, has skin / hair / teeth /
etc
Do a cystectomy for definitive dx & to r/o
malignancy!
Immature teratoma = malignant version
Treatment:
for benign tumors (mature teratomas) cystectomy or oophorectomy
for malignant tumors, unilateral salpingo-oophorectomy if fertility desired, or TAH/BSO
everything except stage IA dysgerminomas / immature teratomas gets multiagent chemo
Genetics
Pathology
Presentation
No embryo
Presents with abnormal vaginal bleeding
Classic sx* common
Uterus S>>D
Theca lutein cysts in 25%
Yes embryo
Presents like missed Ab
Classic sx rare
Uterus S=D
Rare theca lutein cysts
2-4% nonmetastatic
not metastatic
Malignant?
*hyperemiesis gravidarum, early PEC, hyperthyroidism, anemia, really big uterus S>>D
Malignant GTD
Types
Persistent / invasive moles (75%)
Arise after evacuation of molar pregnancy: hydropic villi / tropoblasts invade myomet.
Dx: plateauing / rising hCG after tx for molar pregnancy, can have uterine bleeding
Tx: single agent chemo (MTX / actinomycin D) if low risk, multiagent if high risk
Choriocarcinoma (25%)
Tissue diagnosis is the standard in establishing a diagnosis of most all malignancies, with
the exception of choriocarcinoma. Only a positive beta-HCG in a reproductive-aged
woman who has a history of a recent pregnancy (term, miscarriage, termination, mole)
is necessary to establish the diagnosis
Often metastatic, can spread hematogenously (lungs / vagina / pelvis / brain / liver / GI)
Get hCG, CBC/coags, pelvic U/S (doppler really vascular), CXR/chest CT for lungs,
abd/pelvic CT or MRI to look for mets as well.
Solid
fine needle aspiration if < 30 excisional bx if FNA fails, or nondiagnostic
core needle biopsy if > 30
Fibrocystic change:
Painful breast masses that are multiple / bilateral, hormonal response, fluctuates in cycle
Peak incidence in women 30-40 years old
Treat with less caffeine, tea, chocolate (controversial), avoiding trauma, using support bra
Not associated with increased cancer risk
Fibroadenoma
Benign tumor with glandular / stromal components
Usually solitary but can be bilateral; rubbery / nontender, can change during cycle
Peak incidence in women 20-35 years old
Classic fibroadenoma in a woman < 30 may be only solid breast mass not requiring tissue dx
but send S/S discharge for cytology to r/o invasive papillary carcinoma
Tx: excise involved ducts.
Mammary duct ectasia:
Subacute inflammation of ducts dilation inflammation
Usually at or after menopause
Nipple discharge, noncyclic breast pain, nipple retraction, often bilateral
Get mammogram / excisional bx to r/o carcinoma
Risks: increasing age is big one, also personal hx, first degree family hx, esp higher if family member
premenopausal or male, BRCA , ionizing radiation at young age (Hodgkin lymphoma), atypical ductal or
lobular hyperplasia on bx.
Survival rates similar for pregnant / lactating women with breast cancer.
OCP use - no evidence of risk factor.
Dx: often SBE / CBE / mammmo; masses / skin change / dimpling; bloody discharge should be ruled out
50% of tumors in upper outer quadrant.
Mets: to bone, liver, lung, pleura, brain, LNs
Noninvasive disease:
Lobular carcinoma in situ (LCIS) - neoplastic epithelial cells in breast lobules without invasion of stroma
multicentric & bilateral; often picked up incidentally on bx for another finding (cant see on
mammograms and cant palpate on PE)
premalignant lesion - 25-30% risk of invasive breast cancer w/in 15 yrs in either/both breasts
Tx: Observe only; may consider SERM to decrease risk - otherwise close followup
Ductal carcinoma in situ (DCIS) - malignant epithelial cells in mammary ducts, not stroma
Higher capacity to progress to outright invasive ductal cancer in same site
Mammogram clustered microcalcs +/- palpable mass
Dx: needal localization bx or excisional bx if palpable
Invasive disease:
Types
Infiltrating ductal carcinoma (70%) - from ductal epithelium, usually unilateral
Invasive lobular carcionoma (10-20%) - from lobular epithelium, often bilateral
Paget disease of nipple (1-3%) - often with DCIS / invasive carcinoma in subareolar area
Malignant cells invade nipple epidermis eczematous changes w/ scaling, erosion, etc.
Inflammatory breast carcinoma (1-4%) - really aggressive, poorly differentiated
If ER+, usually use tamoxifen x 5 yrs; letrozole / anstrozole (aromatase inhibitors) even
better if postmenopausal (most estrogen coming from fat!)
Remember tamoxifen predisposes to endometrial cancer!
ER+:
consider oophorectomy / GnRH antagonists if premenopausal,
consider tamoxifen / aromatase inhibitors if postmenopausal
Systemic adjuvant chemo along with hormonal therapy if indicated often used
Prognosis: stage is #1 predictor, also ER/PR status and lymph node status
F/U:
PE q3-6mo x 3y, then space to q6mo x 2y, then q12mo
Mammogram @ 6mo, then annually
Avoid HRT