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Pharmaceutical Incompatibility
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0.6gm
Pharmaceutical Incompatibility
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Rx
Tetracycline hydrochloride
250mg
Make capsules, send such 10 capsules.
Label: Take one capsule every six hours with milk.
Type: Therapeutic incompatibility.
In this prescription the direction is wrong. Tetracycline is inactivated by calcium which is
present in milk. Therefore, tetracycline capsules should not be taken with milk.
****
Intentional incompatibility: The drugs i.e. Acetophenatidin and Acetyl salicylic acid are
analgesic. Acetophenatidin is CNS depressant whereas caffeine is CNS stimulant, which
neutralizes the side effect of Acetophenatidin. This is an Intentional incompatibility.
Example
Rx
Acetophenatidin
150mg
Acetyl salicylic acid
200mg
Caffeine
40mg
Make capsules, send such 10 capsules.
Type: Therapeutic incompatibility (Intentional)
***
Diffusible Precipitates: The reaction between the dilute solutions proceed at a slow rate
and the precipitates formed are light and diffuse readily in the solution.
Method A is used when diffusible precipitates are formed and they form very small
portion of the mixture.
Divide the vehicle into two equal portions. Dissolve one of the reacting substances in one
portion and the other in the other portion. Mix the two portions by slowly adding one
portion to the other with rapid stirring.
Indiffusible Precipitates: The reaction between strong solutions proceed at a faster rate
and the precipitates formed are thick and do not diffuse readily in the solution.
Method B is used when indiffusible precipitates are formed and they form an appreciable
portion of the mixture.
Pharmaceutical Incompatibility
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Divide the vehicle into two equal portions. Dissolve one of the reacting substances in one
portion Place the other portion of the vehicle in a mortar, to this incorporate a suitable
amount of compound tragacanth powder with constant trituration until a smooth
mucilage is produced, then add and dissolve the other reacting substances. Mix the two
portions by slowly adding one portion to the other with rapid stirring.