E. TEACHING PLAN
. He
LEARNING
OBJECTIVES
LEARNING CONTENT
LEARNING
STRATEGIE
S
TIME
ALLOTMEN
T AND
RESOURCE
S NEEDED
SPECIFIC
OBJECTIVES:
After 15 minutes
of
nurse-patient
interaction,
the
patient will be
able to:
1. Define
GERD
(Heartburn)
.
2. Identify
cause
of
EVALUATION
FULLY MET IF
After 15 minutes
of nurse-patient
interaction was able
to:
GERD (Heartburn)
Heartburn is a disease that
occurs when gastric contents
flow backward from the stomach
into the esophagus. It is also
termed
reflux
and gastroesophageal
reflux
disease (GERD).An
uneasy burning sensation in
the stomach,typically extending t
oward the esophagus, andsometi
mes associated with the eructati
on of anacid fluid.
Lecture and
discussion
Lecture and
discussion
2 minutes
(pamphlet)
2 minutes
(pamphlet)
a. Understand
heartburn
b. Know the
cause of
heartburn
c. State the
foods and
activities
that trigger
heartburn.
d. Identify
ways to
prevent
heartburn
PARTIALLY MET
IF:
Patient answered
correctly some of
the health
GERD.
3. Enumerate
foods that
can trigger
heartburn.
Foods
that
heartburn
that
can
Lecture and
discussion
3 minutes
(pamphlet)
Lecture and
discussion
2 minutes
(pamphlet)
Lecture and
discussion
6 minutes
(pamphlet)
trigger
Activities
the
heartburn
4. State
activities
that
can
trigger
heartburn.
can
objectives.
trigger
Smoking.
Overeating.
Wearing
tight
clothing
around the waist.
5. Identify
ways
on
how
to
prevent
heartburn.
HEARTBURN PREVENTION
. Don't Overeat
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High-fat meats
White meat
Creamy sauces
Chocolate
Peppermint
Carbonated beverages
Alcohol
Spicy foods
Tomato-based products
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Grilled foods
Broth-based soups
Steamed vegetables
Mechanism of action
Amlodipine is a dihydropyridine calcium antagonist (calcium ion antagonist or slow-channel blocker) that inhibits the movement of calcium ions into vascular
smooth muscle cells and cardiac muscle cells. Experimental data suggest amlodipine binds to both dihydropyridine and nondihydropyridine binding sites. The
contractile processes of cardiac muscle and vascular smooth muscle are dependent upon the movement of extracellular calcium ions into these cells through
specific ion channels. Amlodipine inhibits calcium ion influx across cell membranes selectively, with a greater effect on vascular smooth muscle cells than on
cardiac muscle cells. Negative inotropic effects, or decreased heart muscle contractility, can be detected in vitro, but such effects have not been seen in intact
animals at therapeutic doses. Serum calcium concentration is not affected by amlodipine. Within the physiologic pH range, amlodipine is an ionized compound
(pKa = 8.6), and its interaction with the calcium channel receptor is characterized by a gradual rate of association and dissociation with the receptor binding
site, resulting in a gradual onset of effect.
Amlodipine is a peripheral arterial vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction
in blood pressure. Also, as a calcium channel blocker amlodipine is expected to inhibit the currents of L-type Cav1.3 channels in the zona glomerulosa of
the adrenal cortex, reducing aldosteroneproduction and corroborating to lower blood pressure.
Amlodipine belongs to a class of medications called calcium channel blockers (CCBs). These medications block the transport of calcium into the smooth
muscle cells lining the arteries of the heart (coronary arteries) and other arteries of the body. Since the action of calcium is important for muscle
contraction, blocking calcium transport relaxes arterial muscles and expands (dilates) coronary arteries and other arteries of the body. By dilating
coronary arteries, amlodipine increases the flow of blood to the heart and is useful in preventing heart pain (angina) resulting from reduced flow of
blood to the heart caused by coronary artery spasm (contraction). Relaxing the muscles lining the arteries in the rest of the body lowers blood pressure,
which reduces the work that the heart must do to pump blood to the body. Reducing the work of the heart also lessens the heart muscle's need for
oxygen, and thereby further helps to prevent angina in patients with coronary artery disease.
y it is prescribed (Indications) :
This combination medication contains proton pump inhibitor and an antidopaminergic agent, prescribed for dyspepsia and gastro-esophageal reflux disease.
When it is not to be taken (Contraindications):
Hypersensitivity and lactation.
Pharmacokinetics
Pantoprazole acts by selectively inhibiting the H+/K+-ATPase enzyme in the secretory canaliculus of the stimulated parietal cell. Domperidone stimulates GI
activity by acting as a competitive antagonist at dopamine D2-receptors.
Pantoprazole 40mg and Domperidone 30mg Sustained release (SR) Capsule containing Sodium.
The sodium bicarbonate works by slowing the breakdown of the PPI in the stomach, which helps to increase absorption of the PPI.
2 in 1 combination tablet of Pantoprazole 40mg +Domperidone 30mg.
Mechanism of Action[edit]
Domperidone is a peripheral dopamine (D2) and (D3) receptor antagonist. It provides relief from nausea by blocking receptors at the chemo-receptor trigger
zone (a location in the nervous system that registers nausea) at the floor of the fourth ventricle (a location near the brain). It increases motility in the upper
gastrointestinal tract to a moderate degree and increases [4] lower esophageal sphincter pressure by blocking dopamine receptors in the gastric antrum and
the duodenum. It blocks dopamine receptors in the posterior pituitary gland increasing release of prolactin which in turn increaseslactation.[5][6] Domperidone
may be more useful in some patients and cause harm in others by way of the genetic characteristic of the person, such aspolymorphisms in the drug
transporter gene ABCB1, the potassium channel KCNH2 gene, and 1Dadrenoceptor ADRA1D gene
Altered comfort: dyspepsia
related to:
1.
2.
reflux of gastric contents associated with increased intraabdominal pressure resulting from ascites;
3.
4.
D.
E.
1.
2.
3.
II.
B.
C.
F.
I.
II.
carbonated beverages
III.
IV.
The Food and Drug Administration warned today that people who
take the blood thinner clopidogrel (Plavix) should not take the
heartburn drugs omeprazole (Prilosec, Prilosec OTC, and
generics) and esomeprazole (Nexium) because two new studies
confirm that the combination could have dangerous
consequences. The studies show that omeprazole and
esomeprazoleboth members of a class of stomach acidreducing drugs called proton pump inhibitors, or PPIscan lower
the effectiveness of Plavix , putting people at risk of heart attacks
or strokes.
Plavix is given to people after a heart attack to help reduce the
risk of blood clots that can trigger another attack. The drug can be
hard on the stomach and cause gastrointestinal bleeding, so
people are often prescribed a PPI treatment, which reduces the
amount of acid in the stomach and lowers the risk of stomach
bleeding. But previous studies suggested this drug combination
may actually increase the risk of having another heart attack. The
FDAs warning is based on two new studies from the makers of
Plavix that show that both omeprazole and esomeprazole reduce