Natural products, as the term implies, are those chemical compounds derived from living
organisms and the study of natural products is the investigation of their structure,
formation, use and purpose in the organism. Drugs derived from natural products are
usually secondary metabolites and their derivatives. Today those must be pure and highly
characterized compounds. Since prehistoric times, the humans have relied on natural
products as a primary source of medicine. Plants and animals were used to bring back the
health of sick and frail. Plant were found to be beneficial as food, fodder, medicine etc. but
also harmful as being poisonous and toxic (Fuller and Hemrick, 1985). The application of
herbs for external and internal use has always been a major factor in practice of
medicine (Steiner, 1986). The experience and knowledge gained in using the traditional
medicines in different regions over the millennia resulted in the complex science of modern
medication.
However many approaches evolved over time towards the taxonomy of plants.
1.3. CHEMOTAXONOMY
Chemotaxonomy is also called chemosystematics or biochemical systematics. The
science of chemical taxonomy is used on the classification of plants on the basis of their
chemical constituents which are deeply concerned with the molecular characteristics.
The method of chemical taxonomy is simple in principal and is based on the investigations
of the distribution of chemical compounds or groups of biosynthetically related
of
general
occurrence.
For
example
leaving
aside
the
family of
but
differs
from
anthocyanins.
It
appears
that,
with
the
exception
caryophyllaceae, these families are closely related and therefore caryophyllaceae may be
isolated. -cyanin also occurs in cactaceae and therefore, the members of caryophyllales
are phylogenetically related. There are certain other chemical connections between
cactaceae
and
members
of
caryophyllales
e.g.
Oleic acid) occurs and these two families are related and belong to the same order. The
other examples are from Magnoliales
Ranals
taxa,
where
it
is
shown
that
families
are
loosely
related.
On
the
other
hand
Asclepiadaceae and Gentianaceae are allied due to the common occurrence of pyridine. The
lilliaceae and Amarylldeceae are closely associated and this is supported by the
presence of Isoquinoline in both. A number of citations regarding chemotaxonomy
and secondary metabolites further.
Solanum nigrum is the most variable species of the genus Solanum. The species related
to S. nigrum have been reclassified innumerable times. Characters used by later
taxonomists to separate and describe additional taxa often differed very slightly from those
given for species by earlier workers. These Solanum species display varying amounts of
phenotypic variation, particularly in their vegetative features such as plant habit, leaf
size and form, and stem winging. In addition, senescence is often accompanied by smaller
and fewer flowers and fruits (Ganapathi and Rao, 1986).
S. nigrum was first delimited in four taxa with polynomials by Dillenius. Linnaeus
subsequently modified Dilleniuss work, describing these in six varieties under the
binomial S. nigrum (Edmonds and Chweya, 1997). Since then, the plants morphologically
related to S. nigrum have been reclassified many times. Over 300 post-Linnean specific
and infraspecific names have now been published, and synonymy is extensive within
the section. However, no satisfactory revision of the whole section has yet been devised.
The boundaries between many of the species are still ill-defined, with many of the new
taxa proving to be no more than slight morphological
variants
of those
already
described. The situation is further complicated by the researchers who either treated
different members of the section as varieties of S. nigrum or considered them as
different species on the basis of morphological
Chweya,
1997;
Schilling
differences
(e.g.
Edmonds
and
Though
S.
americanum
Mill.,
S.
encountered
in
the
explain
some
of
the
However with the rapid progress in the isolation, purification, identification, elucidation of
structure and the configuration of natural plant products, the phytochemists and
ethnobotanists believe that it is possible to characterize and classify the plants on the
basis of their chemical constituents. The chemical constituents are formed within the plants
by definite biosynthetic pathways aided by the specific enzymes.