THERAPY WORKSHEET

Efficacy and Safety of Clindamycin Phosphate 1.2% and Tretinoin 0.025% Gel for
the Treatment of Acne and Acne induced Post-inflammatory Hyperpigmentation in
Patients with Skin of Color
Are the results of this single preventive or therapeutic trial valid?
Was the assignment of patients to
treatments randomised?
Was the randomisation list concealed?
Was follow-up of patients sufficiently
long and complete?
Were all patients analysed in the groups to
which they were randomised?
Were patients and clinicians kept blind
to treatment?
Were the groups treated equally, apart
from the experimental treatment?
Were the groups similar at the start of the
trial?

Ya. Pada bagian Methods khususnya

dijelaskan pada Study Procedures bahwa
pasien dikelompokkan secara acak.
Ya. Pada penelitian ini pasien diikuti
selama 12 minggu.
Ya. Semua pasien dianalisis dalam
kelompok mereka diacak.
Ya. Pada bagian Methods khususnya di
Study Procedures dijelaskan bahwa
pasien dan dokter tidak mengetahui obat
yang digunakan (double-blind).
Ya. Kelompok kontrol dan percobaan
diterapi dengan memberikan topikal
selama 12 minggu.
Ya. Kelompok dalam penelitian tetap
sama mulai dari awal penelitian.

Are the valid results of this randomised trial important?

Pengobatan selama 12 minggu
dengan klindamisin fosfat
1.2% dan tretinoin 0.025%
pada lesi inflamasi
CER
EER
11,36 %

6,56 %

Pengobatan selama 12 minggu

Relative risk
reduction
(RRR)

Absolute risk
reduction
(ARR)

Number
needed to
treat (NNT)

CER EER
CER
42,25 %

CER-EER

1/ARR

4,8 %

20

Relative risk

Absolute risk

Number

dengan klindamisin fosfat

1.2% dan tretinoin 0.025%
pada lesi non-inflamasi
CER
EER
40,08 %

22,60 %

reduction
(RRR)

reduction
(ARR)

needed to
treat (NNT)

CER EER
CER
43,61 %

CER-EER

1/ARR

17,48 %

Can you apply this valid, important evidence about therapy in caring for your
patient?
Do these results apply to your patient?
Is your patient so different from those in Tidak. Penderita acne vulgaris di Indonesia
the study that its results cannot apply?
sering ditemui dan tidak berbeda dengan
partisipan dalam penelitian ini.
Is the treatment feasible in your setting? Ya. Bisa karena formula ini sudah ada di
pasaran.
What are your patients potential benefits and harms from the therapy?
NNT pada lesi inflamasi
20
NNT pada lesi non-inflamasi
5
Are your patients values and preferences satisfied by the regimen and its
consequences?
Do your patient and you have a clear
Tentu saja pasien menginginkan
assessment of their values and
pengobatan yang aman, murah dan mudah.
preferences?
Are they met by this regimen and its
Bisa dilakukan
consequences?