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FORENSIC TOXICOLOGY
Introduction
Forensic Toxicology is a branch of Forensic Medicine dealing with Medical and Legal aspects of
the harmful effects of chemicals on human beings. Below given are described the general
considerations of Forensic Toxicology useful for Undergraduate and Post-Graduate Student of
Forensic Medicine.
Poisoning in India: Suicidal (KCN, HCL, Opium, Barbiturates, organophosphorus, oxalic acid
oleander etc), homicidal(arsenic, aconite, thallium, oleander, madar, carbamates,
organophosphorus etc.) and accidental poisoning are seen in India. Older poisons like opium and
arsenic are replaced by newer poisons. Common
homicidal poisons are: Arsenic, Antimony, Oleander, Nux-Vomica, Madar, powdered glass and
aconite.
Cattle Poisoning is also common, the poison used are Arsenic, Abrus precatrotius, Yellow
oleander, zinc phosphide, nitrates, aconite etc.
Important Definitions:
Toxicology is the science dealing with properties, action, toxicity, fatal dose, detection estimation
of, interpretation of the result of toxicological analysis and management of Poisons.
Poison: A Poison is defined as any substance which when administered in living body through any
route (Inhalation, Ingestion, surface absorption etc) will produce ill-health or death by its action
which is due to its physical chemical or physiological properties. Eg: alphose, sulphuric acid,
arsenic etc.
Drug (WHO 1996): Drug is any substance or product that is used or intended to be used to modify
or explore physiological systems or pathological states for the benefit of the recipient.
Eg: paracetamol, ciprofloxacin, salbutamol, oestrogen, insulin etc.
Clinical Toxicology: Deals with human diseases caused by, or associated with abnormal exposure
to chemical substances.
Toxinology refers to toxins produced by living organism which are dangerous to man, eg: snake
venom, fungal and bacterial toxins etc.
Chelating Agents: are the substances which act on absorbed metallic poisons. They have greater
affinity for metals as compared to endogenous enzymes. The complex of agent and metal is more
water soluble than metal itself, resulting in higher renal excretion of the complex.
E.g.: British anti-lewisite (B.A.L., dimercaprol), E.D.T.A. (ethylene diamine-acetic acid),
Penicillamine (Cuprimine), Desferroxamine etc.
Ecotoxicology: It is concerned with the toxic effects of chemical and physical agents on living
organisms, especially in population and communities within defined population.
Acute poisoning is caused by an excessive single dose, or several dose of a poison taken over a
short interval of time.
Chronic Poisoning is caused by smaller doses over a period of time, resulting in gradual
worsening. eg: arsenic, phosphorus, antimony and opium.
Subacute poisoning shows features of both acute and chronic poisoning.
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Sources
Poison: is produced by a massive dose. In this death occur rapidly, sometimes
Fulminantof
poisoning
1.
without
Domestic
preceding
or household
symptoms.sources - In domestic environment poisoning may
more commonly
occur
from detergents,
disinfectants, cleaning agents,
Parasuicide
antiseptics,(attempted
insecticides,
suicide
rodenticides
or pseudicide)
etc. is a conscious often impulsive, manipulative act,
2.
undertaken
Agricultural
to getand
rid horticultural
of an intolerable
sourcessituation.
different insecticidws, pesticides,
fungicides and weed killers.
3.
Culpable
Industrial
Homicide:
sourcesSec
In299
factories,
IPC; Causing
where poisons
death ofare
a person
manufactured
by an act,
or poisons
with the intention of
causing
are produced
such bodily
as by
injury
products.
and is likely to cause death, or with the knowledge that he is likely, by
4.
such
Commercial
an act to cause
sourcesdeath.From store-houses, distribution centers and selling
Antidote:
shops.
Antidotes are substances which counteract the effect of poison. They are divided into
5.
Mechanical,
From
Chemical,
uses
as
Physiological
drugs
andand
specific
medicines
receptor antagonists.
Due
to wrong
medication,
overmedication and abuse of drugs.
6.
Laws
Food
in relation
and drink
to poison
contamination
and drugs:
in way
Different
of usesections
of preservatives
of Indianofpenal
food code
grains or
related
othertofood
poisons
material,
are as
additives
follows like colouring and odouring agents or other ways
of
Sec.
accidental
272 I.P.C.
contamination
- Punishment
of for
food
adulterating
and drink. food or drink intended for sale, so
7.
as to
Miscellaneous
make the. same
sourcesnoxious,
snakes
may extend
bite poisoning,
upto 6 months
city smoke,
imprisonment
sewer gas
of either
term
poisoning
and/or fine
etc.upto one thousand rupees.
Sec. 273 I.P.C. - Punishment for selling noxious food or drink may be
imprisonment of either description for a period of 6. months and or fine upto one
thousand
rupees.of poisons
Classification
274 I.P.C.
- Punishment
for adulteration
1. Sec.
According
to the
site and mode
of action of drugs in any form with any
change
in its
effect knowing that it Will be sold and used as un-adulterated drug,
(A).
local
Action
may beCorrosive:
imprisonment of either description for a period-of 6 months and or fine.
Strong Acid: mineral acid and organic acid
Sec. 275 Strong
l.P.C. -alkali
Punishment for knowingly selling adulterated drugs with less
efficacy or altered
action
serving
it for use as unadulterated may be imprisonment
Metallic:
Mercuric
Chloride
of eitherIrritant:
description for 6 months and or fine.
Sec. 276 I.P.C. - Punishment for selling a drug as a different drug or
Mechanical: Glass Powder.
Preparation,
may be imprisonment of either description which may extend upto 6
Chemical:
months and or fine. .
Inorganic: weak acid, weak alkalies, Inorganic non-metals, Inorganic metals.
Note - In the State of West Bengal, the punishment for these offences described
Chemical
under sections 272Organic:
to 276 may
be uptopreparations,
imprisonmentAnimal
for life and
withvegetable
or withoutorigin
fine.
Sec. 277 I.P.C. Punishment for fouling water of public spring or reservoir may
(B)
Remote Action
be imprisonment
of either description which may extend up to a period of 3 months
Neurotics
and or fine.
C.N.S.
Poisons for voluntarily making atmosphere noxious to
Sec. 278 I.P.C.
- Punishment
i. Somniferous:
opium
and its
alkaloids, Barbiturates.
health is fine which . may
extend upto five
hundred
rupees.
ii.
Inebriant
(Intoxicant):
Alcohol,
Chloroform.
Sec. 284 I.P.C. Punishment for negligent conduct withether,
respect
to poisonous
iii.
Stimulant
substance may be imprisonment of either description which may extend upto 6
iv. Deliriant:
Dhatura,
Belladona,
Hyocyamus,
months and or fine which
may extend
upto one
thousand
rupees. cannabia indica.
v. Stupefaciant
Sec. 328 I.P.C. :Punishment'
for causing hurt by means of poison or any
vi.
Hallucinogens
stupefying, intoxicating or
unwhlolesome drug or any other thing with the intent to
vii. Convulsant:
commit an offence shall be imprisonment of either description for a term which may
extend to ten years
Spinal
with (Convulsant)
or without fine.
i.
Strychnos Nux Vomica
Peripheral Nerves
i.
Local Anaesthetics: Cocaine, Procaine.
ii. Relaxants (curare).
Cardiac Poisons
KCN, NaCN, Digitalis, Aconite, Nicotine, Quinine, Oleander
Asphyxiants: Carbon Dioxide, CO, hydrogen sulphide
Nephrotoxic: Oxalic Acid, Mercury, Cantherides
Hepatotoxic: Phosphorus, Carbon tetrachloride, Chloroform.
Miscellaneous: Food Poisons.
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Route of Administration/absorbtion:
Oral (commonest) eg: alphos, acids,
Inhalation: gas poison
Parenteral (IM, IV, Sub-Cutaneous, Intra-Dermal)
Natural Orifices other than mouth (Nasal, Rectal, Vaginal, Urethral),
Ulcers, wounds and intact skin.
Fate of poison in body:
A part of the poison taken orally gets eliminated
unabsorbed by means of defecation and vomiting. Before absorption the poison
may exert its effects in the G.I. Tract. When absorbed, the poison reaches different
parts of the body and organs through circulation. Some poisons reach some
tissues easily. Others may not cross some tissue barrier. Cumulative poisons get
accumulated in some organs or tissues. A part of poison is eliminated as such
through different route of elimination. But major part is detoxified or metabolized in
the body and than excreted after exerting its toxic effects on the body. Liver is the
main organ to detoxify or metabolize most of the poisons.
Certain poisons like Chloroform, Phosphorus, Nitrates and Acetic acid disappear
by evaporation or oxidized or destroyed in the body and no trace of them can be
detected in the body of post-mortem is delayed.
Excretion of poisons:
Unabsorbed poisons are excreted through faeces and
vomitus. Absorbed poisons are excreted mostly by urine. A part of volatile poison
is exhaled out. Some portion of poison is excreted through bile, saliva, milk, sweat,
tear, hair and nails.
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Diagnosis of poisoning
In the Living
1.
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21. Chest cavity -Smell of volatile poisons cyanogen, opium etc. can be detected.
22. Lungs - Voluminous, congested, presence of Tardieu's spots - In case of
asphyxiants and inhaled poisons. Cut section gives blood stained frothy-fluid in
case of opium and other asphyxiants.
23. Heart- Presence of subendocardial haemorrhagic spots in cases of arsenic,
phosphorus, mercuric chloride etc.
24. Brain and spinal cord - Congestion and edema of brain and spinal cord in
cases of cerebral and spinal poison (e.g. strychnine: respectively. Brain may be
congested. oedematous with occasional haemarrhagic points at places in cases of
asphyxiant poisons.
25. Uterus and vagina- Staining, congestion haemorthage, ulceration in cases of
attempted abortion by use of local abortifacient agents.
Preservation of viscera and other materials
In all cases of poisoning
1. Stomach with its full contents.
2. Half of Liver or 500 gms whichever is more.
3. A loop of small intestine.
4. Half of each kidney.
5. Some portion of spleen
In some particular poisons
1. Blood 100ml: in cases of absorbed poisons.
2. Urine 100ml in all cases where blood is preserved.
3. Part of both lungs in cases of Volatile poisons.
4. Heart in case of cardiac poisons.
5. Brain in cerebral poisons.
6. Spinal in spinal poisons.
7. Bones in arsenic and lead.
8. Hair in arsenic and copper.
9. Nails in arsenic.
10. Skin-scrap from areas stained with a suspected poison.
11. Stained areas of dress, suspected packet of poision, strips of tablets recovered from pocket.
Preservative used
For Viscera: absolute alcohol or rectified spirit. Exception: alcohol, chloroform,
chloral hydrate, formaldehyde, ether, phosphorus (alcohol prevents the luminosity
of phosphorus in dark) etc.
Blood should be preserved in fluoride, oxalate, E.D.T.A., gold chloride or citrate
Urine and clothes: without any preservative.
Management of a case of poisoning
Immediate resuscitative (Basic Management) measures in comatose patient should
be adopted to stabilize respiration, circulation and the correct CNS depression.
A) Airway: opening up and cleaning the airways (oral cavity, Nostrils) of
secretions, vomit or any foreign body. Pull tongue forward
B) Breathing : Supplemental oxygen therapy should be administered
C) Circulation: I.V. fluid administration
D) Depression of CNS should be corrected
Specific Management
1. Removal of patient from source of exposure: Patient should be removed
away from the source of poison as quickly as possible.
2. Removal of the unabsorbed poison . In case of contact poison washing of
affected area with soap water with gentle rubbing will be helpful. In cases of
ingested poisons Gastric lavage is useful within 3 hours of ingestion and is
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(i) In case of death, death certificate should mention about the poisoning or
suspected poisoning with recommendation for post-mortem examination. .
WHO recognized Poison Information Centers in India
Ahmedabad
Poisons Information Centre
National Institute of Occupational Health, Meghani Nagar
Ahmedabad 380 016
Director: Dr A. Dewan
Telephone: +91 79 286 7351
Emergency telephone: +91 79 562 1400
Fax: +91 79 286 6630
E-mail: dewan4@satyam.net.in
Cochin
Dept of Toxicology
(Incl. Poison Information & Laboratory Services )
Amrita Institute of Medical Sciences & Research
Cochin 682026, South India
Director: Dr V. V. Pillay
Telephone: +91 484 2804852 (O), +91 484 2807055 (R),
9895282388 (Cell 24 hrs)
Fax: +91 484 2802051
E-mail: mailto:toxicology@medical.amrita.edu;
poisonunit@aimshospital.org
Chennai
Toxicology & IMCU Unit
Government General Hospital
Chennai
Director: Dr C.Rajendran M.D
Telephone: +91 44 536 3208 or + 91 44 536 3131 ext. 108
Fax: +91 44 538 8521
E-mail: ghpictn@vsnl.net
Web site: http://www.chennaipic.com/
Information also at http://www.whoindia.org/ and go to
Environment health/Poison Prevention/Helpline
New Delhi
National Poisons Information Centre
All India Institute of Medical Sciences , Ansari Nagar
New Delhi 110 029
Telephone: +91 11 6859391
Emergency telephone: +91 11 661123
Fax: +91 11 6859391
Note: The above notes and other teaching material are also available on the departmental website www.forensicindia.com
Source: www.forensicindia.com
By: Dr. Imran Sabri, Department of Forensic Medicine, J.N. Medical College, A.M.U. Aligarh.
Forensic toxicology is essentially a specialty area of analytical chemistry. Toxicology is the science of
adverse effects of chemicals on living organisms. In general, a toxicologist detects and identifies foreign
chemicals in the body, with a particular emphasis upon toxic or hazardous substances. A descriptive
toxicologist performs toxicity tests to evaluate the risk that exposure poses to humans. A mechanistic
toxicologist attempts to determine how substances exert deleterious effects on living organisms. A
regulatory toxicologist judges whether or not a substance has low enough risk to justify making it available
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regulatory toxicologist judges whether or not a substance has low enough risk to justify making it available
to the public.
A toxin is any material exerting a life threatening effect upon a living organism. Poisons are a subgroup of
toxins. Toxic materials exist in many forms (gaseous, liquid, solid, animal, mineral, and vegetable), and may
be ingested, inhaled, or absorbed through the skin. Poisons generally enter the body in a single massive
dose, or accumulate to a massive dose over time. Toxins work in minute quantities or low levels, requiring
sensitive analytical instruments for detection. Some toxins have medicinal value, but many produce
irreparable damage. Some toxins have antidotes and others do not. Poisons can be combated by prompt
treatment, and most organ damage (except for serious CNS injury) may be repairable. Whereas poisons
are somewhat easily identifiable by their symptoms, many toxins tend to disguise or mask themselves.
Here's a list of the more common poisons and their symptoms:
Acids (nitric, hydrochloric, sulphuric)
Odor of disinfectant
Carbon monoxide
Cyanide
Food poisoning
Metallic compounds
Nicotine
Convulsion
Opiates
Odor of garlic
Sodium fluoride
Convulsion
Strychnine
The true incidence of poisoning in the United States is unknown. Approximately 2 million cases are
voluntarily reported to poison control centers each year, and officially, a rather steady figure of about 700
deaths by poisoning is reported each year. Children under age 6 account for the majority of poisonings
reported, but adults account for the majority of deaths by poisoning, most of which is intentional rather than
accidental. The following tables show a ranking of the most frequently reported poisonings (left) compared
to the most frequent deaths by poisoning (right):
1 - Household cleaning supplies
1 - Antidepressant medications
2 - Analgesics (aspirin,
acetaminophen)
2 - Analgesics (aspirin,
acetaminophen)
3 - Cosmetics
3 - Street drugs
4 - Cardiovascular drugs
5 - Alcohol
6 - Pesticides
7 - Asthma therapies
9 - Pesticides
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10 Sedatives/hypnotics/antipsychotics
11 - Food poisoning
11 - Anticonvulsant medications
12 - Alcohol
Paracelsus (1493-1541) once said "All substances are poisons; there is none which is not a poison. The
right dose differentiates a poison and a remedy." Although society wants the toxicologist to categorize all
chemicals as either safe or toxic, this is not possible. It is not easy to distinguish toxic from nontoxic
substances. A key principle in toxicology is the dose-response relationship. There is a graded doseresponse relationship in individuals, and a quantal dose-response relationship in the population. The
quantal dose-response is the more important one, used to determine the median lethal dose (LDm) and
judge what percentage of the population is affected by a dose increase. Quantal is a term meaning "all or
none", and comes closest to a classification of whether something is safe or toxic.
Chemicals are tested for toxicity and the estimation of LDm using at least two (2) animal species by at
least two (2) routes of administration. One of these portals or routes of administration is supposed to be the
suspected portal for how human beings are exposed. Most animals die within 14 days, and their symptoms
are carefully recorded. Subacute exposure is tested for a period of 90 days. Long-term exposure testing
takes 6 months to 2 years. Cancer research goes on for the life of the animal, or in the case of the Ames
test, to see if reverse mutation occurs to predict carcinogenic effects. Mathematical extrapolation is used to
generalize results from animal testing to human risk incidence. A 0.01% risk in the human population
represents 25,000 people in a population of 250 million, and to have valid extrapolation at this level, a
minimum of 30,000 animals would have to be tested. Humans are generally more vulnerable than animals,
so the calculations are inherently conservative.
The toxic effects of substances are not side effects. Side effects are defined as non-deleterious, such as
dry mouth, for example. Toxic effects are the undesirable results of a direct effect. They occur in a number
of ways, most often produced by a dangerous metabolite of the drug which is activated by an enzyme, light,
or oxygen reaction in a process known as biotransformation. Toxic reactions often depend on how
metabolites are processed by an individual's body, how proteins build up and bind at effector sites in the
body. Some metabolites destroy liver cells, others brain tissue, and still others operate at the DNA level.
Toxic reactions are classified as one of three (3) reactions:
pharmacological -- injury to the central nervous system (CNS)
pathological -- injury to the liver
genotoxic -- creation of benign or malignant neoplasms or tumors
If the concentration of toxin doesn't reach a critical level, the effects will usually be reversible.
Pharmacological reactions, for example, are of this type. In order to sustain permanent brain damage,
dosages must be above a standard critical level. Pathological reactions can be repaired if discovered early
enough, but most liver damage occurs over a period of few months to a decade. Genotoxic or carcinogenic
effects may take 20-40 years before tumors develop. Most of the time, toxic metabolites are activated by
enzymatic transformation, but a few are activated by light. This means that exposure of the skin to sunlight
produces a photoallergic reaction or phototoxic reaction within 24 hours. It's important to understand that
the target organ of toxicity is not the site where toxin accumulates. Lead poisoning, for example, results in
an accumulation of lead in bone marrow, but the toxic effect is the creation of lesions on skin and soft
tissue. Carcinogenesis is even more complicated, involving the creation of promotor electrophiles which
serve to activate or potentiate the growth of latent tumors given some biological trigger or subsequent
environmental attack. Different people, of course, have chemical allergies (as well as food allergies),
depending upon the serology of their allergen-antigen history. In such people, toxic reactions take different
forms. Other people have what are called idosyncratic reactions, which means they have certain unique
genetic triggers. Furthermore, people exposed to multiple toxins can have synergistic reactions, which
means that two or more toxins interact at the metabolic level to be greater or less than the effects of the
individual toxins.
QUALIFICATIONS
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QUALIFICATIONS
For certification as a toxicologist, an individual must possess a Ph.D. or doctorate in one of the natural
sciences. Undergraduate degrees must also be in these areas (biology or chemistry, usually). Grandfather
clauses exist in many states for those lacking the requisite degree level, but who have been working six
years or more in the field. Certification is bestowed by the American Board of Forensic Toxicology, and the
expert may use the title of "Diplomate" which must be renewed every three years. Board-certified
toxicologists will never face difficulties qualifying as an expert witness. State crime laboratories may not
have a toxicologist on staff, their functions being performed by a criminalist, a biochemist, a forensic
biologist, or other technician. Such personnel would normally possess a Bachelor's or Master's degree. A
few states have laws which make toxicological examinations admissible by statute without the necessity for
testimony by an expert, the purpose of which is to insulate and protect their crime lab technicians. Other
states rely upon their Chief Medical Examiner's office, local hospitals, and forensic pathologists or
serologists. Professors are usually not "borrowed" from nearby universities as experts as in the case with
forensic serology. Toxicology services vary widely from state-to-state.
There are about 120 poison control centers in the United States, 34 of these designated as regional
centers. They are coordinated and served by the FDA's Poisoning Surveillance and Epidemiology Branch.
Many toxicologists work for the FDA (Food and Drug Administration) which is responsible for regulating
drugs, medical devices, cosmetics, acceptable daily intake (ADI) of food additives, and enforcing the Delany
Amendment, which says that no cancer-producing substance should be added to our diet in any amount.
Other agencies where toxicologists are often found include the EPA (Environmental Protection Agency)
which is responsible for regulation of pesticides, toxic chemicals, hazardous wastes, and toxic pollutants in
water and air. OSHA (Occupational Safety and Health Administration) also uses toxicologists to determine if
chemicals in workplace air is below a threshold limit value (TLV). The Consumer Products Safety
Commission regulates all products, typically those sold for use in homes, schools, or recreation, not
regulated by the FDA or EPA.
A forensic toxicologist is normally presented with preserved samples of body fluids, stomach contents,
and organ parts. They will have access to the coroner's report which should contain information on various
signs and symptoms as well as other postmortem data. The toxicologist needs a through knowledge of how
the body alters or metabolizes drugs because few substances leave the body in the same state as they
entered. The substances they work with are often derivatives, which is a term meaning a chemical
compound which is prepared from a pure compound in order to be more easily detected by the analytical
techniques used. They also divide specimens up into acidic and basic fractions for drug extraction from
tissue or fluid. Almost all drugs are either acids or bases (on a pH scale from 0 to 14 with closer to 0 being
acids and closer to 14 being bases). Acid drugs are easily extracted with a pH solution of less than 7; base
drugs are easily extracted with a pH solution of greater than 7. As an example, most of the barbiturate drugs
are acid-soluble; most of the amphetamine drugs are base-soluble.
After preliminary acid-base procedures are carried out, and the tissue or fluid sample is now a drug
sample, examination continues in two steps: (1) screening tests, and (2) confirmation testing. Screening
tests allow the processing of many specimens for a wide range of toxins in a short time. Any positive
indications from the screening tests must be verified with a confirmation test. The following are some
standard laboratory tests for toxin detection:
SCREENING TESTS
Physical tests -- boiling point, melting point, density, and refractive index
Crystal tests -- treatment with a chemical reagent to produce crystals
Chemical spot tests -- treatment with a chemical reagent to produce color changes
Chromatography (thin-layer or gas) -- used to separate components of a mixture
CONFIRMATION TESTS
Mass spectrometry -- this is a combination of gas chromatography/mass spectrometry which is
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Marijuana
LSD
Cocaine
Barbiturates
Opium is a true narcotic, providing an euphoric escape from reality. It is derived from the milky secretions
of the poppy bulb before flowering. In raw form, it turns dark brown and stays moist. The most common type
of opiates are:
Morphine -- a natural alkaloid that makes up 10% of poppy juice
Paregoric -- morphine mixed with an alcohol solution
Codeine -- alcoholized poppy juice crystals
Heroin -- poppy juice treated with hydrochloric acid; 3x more powerful than morphine
Demerol and Methadone -- synthetic opium-like substances made in laboratories
Marijuana is technically a hallucinogen but has been thrown in with narcotics since Reyna v. State 1968.
It tends to make a person lethargic rather than euphoric (an effect like alcohol but without the aggression).
It's active ingredient is THC (tetrahydrocannabinol) which is contained mostly in the flower tops and to a
lesser extent in stems and seeds. One particular species, Cannabis Sativa, as opposed to other species,
e.g. Cannabis Indica, Cannabis Ruderalis, tends to contain more THC (Delta-9-THC) as the main
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e.g. Cannabis Indica, Cannabis Ruderalis, tends to contain more THC (Delta-9-THC) as the main
cannabinoid, than the other species, if "species" is the right word since Small & Cronquist's (1976) study
found only one single species with two subspecies (Sativa & Indica), each divisible into a cultivated and wild
variety. Cannibis Indica has a significant amount of THC as well, along with several other cannabinoids. It
should be noted that some experts classify Indica as a subspecies of Sativa, thereby frequently missing an
accurate description of Indica's chemical profile. The THC content is heavily affected by the sex of the
plant, with female plants generating substantially more resin than their male conterparts. Toward this end,
during plant growth, males are generally removed before pollination occurs. The average marijuana
cigarette contains only 1% THC while hashish (made from ground flower tops) is 10% THC. Other
hallucinogens include:
Peyote -- green, mushroom-like buttons on cactus plants
Psilocybin -- naturally-growing mushrooms
Mescaline -- the active ingredient in peyote, synthetically produced
LSD -- 400 times stronger than mescaline
PCP -- animal tranquillizer
Nutmeg and Jimson Weed -- other naturally-growing plants
Cocaine is technically a stimulant, but has been thrown in with narcotics since too many cases to
remember. It's a natural alkaloid found in coca leaves (C17 H22 CLNO4). For making what is called
freebase or crack, it's melting point needs to be lowered, and this is done by releasing the hydrochloride in it
(HCL) through mixing it with a sodium substance like baking soda, adding water, letting it cook slowly, and
then letting it cool off. The crystal residue or pellets are called "crack" which is a widely abused drug. Other
stimulants range from the least powerful (benzedrine and dexedrine) to the most powerful
(methamphetamine).
Barbiturates are known by the color of their tablets: Nembutal (yellow jackets); Seconal (reds); Tuinal
(Christmas trees); and Amytal (blues). Steroids are another group or family of drugs, and the anabolic ones
(that promote muscle growth) exist in about 80 different varieties.
So-called designer or "rave" drugs are hallucinogens, mostly, which have been chemically altered in
some way to as not to be placed on the controlled substances list. However, under emergency measures,
the DEA can put anything on the list they want. Such drugs are: MDMA, XTC, Ice, and Nexus. Here's the
controlled substances list and some sample penalties for trafficking:
Schedule I
(no medical use)
15 years/$125,000
5 years/$50,000
(marijuana)
Schedule II
(some medical use)
Methadone, Morphine,
Cocaine, Amphetamines,
Methamphetamine, PCP
15 years/$125,000
Schedule III
(moderate dependence)
Codeine, Steroids
5 years/$50,000
Schedule IV
(limited dependence)
3 years/$25,000
Schedule V
Cough Syrups
1 year/$10,000
Quite a few interesting defenses exist to a drug charge. With marijuana, for example, one could raise the
"species defense" and then the plant would have to be proved to be Cannibus Sativa. With steroids, one
could raise the "roid rage" defense, that their behavior was out of control. A basic defense is that the person
was not trying to feel good, but feel better, a "medical necessity" defense. It's unconstitutional to make the
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was not trying to feel good, but feel better, a "medical necessity" defense. It's unconstitutional to make the
status of being an addict a crime in itself (Robinson v. California 1962).
Drug charges can also be challenged on scientific grounds, as follows:
Sampling method -- is the fraction tested representative?
Usable vs. Measurable Quantity Rule -- sometimes just a trace is found (as on pipe or bong
scrapes) and case law varies with some states requiring a "usable quantity"
Pure vs. Aggregate Weight Rule -- pure is the uncut amount, but most states follow an
aggregate weight rule so, for example, 10 pounds might refer to the blotter paper the LSD is on
INTERNET RESOURCES
Alan Barbour's Forensic Toxicology Page
Anil Aggrawal's Forensic Career's Page
WWW Virtual Library: Forensic Toxicology
California Association of Toxicologists
American Board of Forensic Toxicology
Future Synthetic Drugs of Abuse
International Association of Forensic Toxicologists
LAPD's Drug Recognition Expert Unit
Society of Forensic Toxicologists
What is a Forensic Pharmacist and How to Become a Pharmacist
Wikipedia Entry on Cannabis
PRINTED RESOURCES
Benjamin, D. (1993). "Forensic Pharmacology" in R. Saferstein (ed.) Forensic Science Handbook. NJ:
Prentice-Hall.
Klaasen, C. (1996). "Principles of Toxicology and Treatment of Poisoning" in J. Hardman et al., Goodman
and Gilman's The Pharmacological Basis of Therapeutics. NY: McGraw-Hill.
Levine, A. (1993). "Forensic Toxicology" Journal of Analytical Chemistry 65: 272-76.
Lowry, W. & J. Garriott. (1979). Forensic Toxicology: Controlled Substances and Dangerous Drugs. NY:
Plenum.
Moenssens, A.A.; Inbau, F.E.; Starrs, J.E. (1986). Scientific Evidence in Civil and Criminal Cases. NY: The
Foundation Press.
Saferstein, R. (1998). Criminalistics: An Introduction to Forensic Science. NJ: Prentice-Hall.
Small, E. & Cronquist, A. (1976). "A Practical and Natural Taxonomy for Cannabis." Taxon 25: 405435.
MegaLinks in Criminal Justice Source: http://faculty.ncwc.edu
Forensic Medicine Source:
Clinical Guidelines for the Determination of Death - New York State Dept. of Health (US)
Forensic Pathology, images - WebPath
Forensic Science Service - Birmingham (UK)
American Academy of Forensic Sciences - (US)
Department of Forensic Medicine - Victorian Inst., Monash University (AU).
Zeno's Forensic Site [Z Geradts] - (NL).
Reddy's Forensic Home Page [RP Chamakura]
Forensic Medicine for Medical Students - (UK)
Forensic Toxicology Page [A Barbour] including the World Wide Web Virtual Library: Forensic Toxicology
Forensic Toxicology Page [A Aggrawal]
American Medical Forensic Specialists
The Forensic Science Society - (UK)
A Beginner's Primer on the Investigation of Forensic Science [K Kruglick] - Scientific Testimony (journal)
Osteo Interactive - Univ of Utah (US)
Adipocere.com
Links to some Forensic Science Resources
Forensic Psychiatry & Medicine [HJ Bursztajn]
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