10/9/13

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(Manufacturer)

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Summary of ecto-parasite treatments

Activyl
(Merck)

Activyl Plus
(Merck)

Advantage II
(Bayer)

Notes

Active Ingredient

Indoxacarb &
Topical for dogs (8 weeks/4 lbs) and cats (8 weeks/2
bioactivation (uses
lbs). Was shown to inhibit 95%-100% of flea
enzymes inside the flea
development in the
to activate product)
environment of treated pets for at least 35 days post-
treatment

Topical for dogs (8 weeks/4 lbs). NO CATS. Let dry if

cat in house. Was shown to inhibit 95%-100% of flea
development in the
environment of treated pets for at least 35 days post-
treatment

Indoxacarb,
permethrin &
bioactivation (uses
enzymes inside the flea
to activate product)

Topical for dogs (7 weeks) and cats (8 weeks). Works Imidacloprid &
on contact so fleas do not have to bite to die. Also kills pyriproxyfen - kills
100% of lice within 1 week on DOGS - one dose.
fleas within 12-24 hrs

Topical for dogs (7 weeks/3 lbs) and cats (9 weeks/2

lbs). Used off-label in guinea pigs for lice. 2 doses one Imidacloprid &
month apart for sarcoptes. Can speed up resolution of moxidectin (different
demodex in young dogs use weekly. Can treat
concentrations for
rounds & hooks in single dose. Good if multiple doses dogs & cats)
if difficult.

Spinetoram kills 98-

Topical for cats (8 weeks). Comes in one dose size that 100% of fleas within 12
can be used on all cats regardless of their weight.
hrs before they lay
eggs

Capstar
(Novartis)

Oral for dogs (4 weeks/2 lbs) and cats (4 weeks/2 lbs)

Nitenpyram starts
comes in 2-25 lb & >25 lb sizes. Can be given rectally
killing fleas within 30
in anesthetized patients. Can be given daily. Not
minutes
effected by bathing/swimming.

Certifect
(Merial)

Advantage Multi
X
(Bayer)

OD

Assurity (Elanco)

Comfortis
(Elanco)
Frontline Plus
(Merial)

O?

Frontline Spray
(Merial)
Frontline Topspot
(Merial)

O?

K9 Advantix II
(Bayer)

Topical for dogs (8 weeks). Causes ticks to detach

within 6 hrs and 100% at 18 hrs

Fibronil, methoprene
& amitraz

Oral for dogs (14 weeks/3.3 lbs) and cats (14 weeks/2
lbs). Provides flea protection for a month. Not
effected by bathing/swimming. Most common side
effect is vomiting.

Spinosad starts to kill

fleas in 30 minutes &
kills 100% of fleas
within 4 hrs

Topical for dogs (8weeks) and cats (8 weeks). Works in Fipronil & S-
sebaceous glands. S-methoprene is the growth
methoprene kills
regulator so is effective against all flea life stages. Also fleas within 24 hrs
kills chewing lice.

Topical for dogs (2 days) and cats (2 days). Ticks are

not killed immediately. 1 squirt/lb, 300 squirts per
bottle. Also kills biting lice and cheyetiella. Online
dosing calculator and chart available.

Topical for dogs (8weeks) and cats (8 weeks). Also kills Fipronil kills fleas
chewing lice, all stages of ticks within 48 hours (except within 12 hours.
ixodes) and cheyetiella. Fleas do not need to bite to
Distribution via
die.
translocation

Topical for dogs (7 weeks). Repels & kills ticks &

Imidacloprid &
mosquitoes, repels biting flies and kills chewing lice. If
permethrin - kills fleas
you need to re-apply, can do as often as weekly. NO
within 12 hrs
CATS. Let dry overnight if cat in house.

Fipronil kills fleas

within 12 hours

Program Flavor
Tabs (Novartis)

Oral for dogs (6 weeks) & cats (4 weeks). Give with

food. Safe to use with an adulticide flea product if
adult fleas are present.

Lufenuron

Program Injectable
(Novartis)

Subcutaneous administration for six months of flea

treatment for cats (6 weeks).

Lufenuron

Program
Suspention
(Novartis)

Oral for cats (6 weeks). Mix packet with 2 tablespoons

of wet food. Safe to use with an adulticide flea
Lufenuron
product if adult fleas are present.

Resultix Spray
(Bayer)
Revolution
(Pfizer)

Sentinel
(Novartis)

Seresto
(Bayer)

Spray on tick killing solution for dogs and cats. Kills

ticks within 3 hours. Dead ticks should fall off but if
not, remove with gloves.

Topical for dogs (6 weeks) and cats (8 weeks). Can be Selamectin kills fleas
used to r/o scabies. Absorbed systemically. Can
within 24 hrs in cats &
purchase largest size and dose out based on weight.
36 hrs in dogs

Vetra

Isopropyl Myristate

Oral for dogs (4 weeks/2lbs). Effective against flea

eggs. If there are adult fleas present add in oral
Capstar or topical adulticide.

Milbemycin &
lufenuron

Collar for dogs (7 weeks) and cats (10 weeks) to

provide 8 months of protection. Also kills chewing lice
for 30 days in dogs. Aids in the treatment and control
of Sarcoptic mange. Can wear when swimming.

Flumethrin &
imidacloprid - kills fleas
in 24 hrs and ticks in 6
hours

Topical for dogs (7 weeks). Repels and kills fleas, ticks, Dinotefuran,
mosquitoes, biting and sand flies and lice. Fleas do not Pyriproxifen &
have to bite to die. NO CATS.
Permethrin

Vectra 3D (Ceva)

(Ceva)
C = cat
D = dog
X = both
O = off-label
O? = questionable efficacy

Dinotefuran kills 96%

Topical for dogs (8 weeks) and cats (8 weeks). Fleas do
of fleas in 6 hrs & 100%
not have to bite to die.
at 12 hrs