2: Lipoma
3: Multiple skin lesions in a Queensland family: (AMC Condition 051)
4: Squamous Cell Carcinoma
5: Marjolin Ulcer (Squamous Cell Carcinoma)
6: Suspicious Lesion (Malignant Melanoma)
7: Psoriasis in a 30yo man (Condition 92)
8: Cellulitis
9: Alopecia Areata
10: Skin Rash (Fungal)
1:
Patient in your GP practice in a small country town comes to you because she has
this rash on shoulder.
Task
o
o
o
DDx:
o
o
o
o
Hx:
o
o
Take history
Diagnosis
Management
Sunburn
Drug (photosensitivity) eg. amiodorone
Contact dermatitis
SLE Discoid eczema
o
o
o
o
o
2:
Your next patient is a 50-year-old male patient presenting with a swelling on his
back.
Task
o Physical examination
(medial margin of the scapula on the right side,
3x5 cm, rounded and well-circumscribed, no
signs in inflammation, lobulated, no presence of
punctum, rubbery in consistency, movable, nontender, no change in temperature
o Diagnosis and management
DDx:
Lipoma
Neurofibromatosis
PEx:
Dx and Mx
3:
You are working in a general practice in a small country town. A 58 year old farmer,
who lives with his family, 160km outside of town, comes to see you as he is
concerned about his family members, having seen a television program about skin
cancer. He has taken photographs of his familys various skin lesions and asks for
your advice about the need for them to seek medical attention, and whether
attendance is urgent. They are all very busy harvesting crops and will be so for
several weeks.
Photo number 5:
o Spider Naevus
Task
o
o
o
Indicate which lesions are likely to be benign, and which are likely to
be malignant or suspicious of malignancy.
Indicate which members of the family require(s) the most urgent
treatment
Indicate the mode of spread of any malignant lesions you diagnose.
o
o
Hello Patrick. Its very thoughtful of you to make photos and bring them with
you today. Lets start with three photos that we are not concerned about
Photo number 3:
o Seborrhoeic Keratosis
o
o
Your brother has Spider Naevus. Its a benign skin lesion. They are
described as spiders due to their appearance. Red central spot
resembling the body of a spider with fine radiating vessels looking
like legs of a spider. Almost all Spider Naevus occur on the upper
part of the body. Spider Naevus may be an indication of underlying
liver disease but can also occur in a healthy individuals. Its a benign
skin lesion. Ideally Id like to see your brother to organize LFT +/ultrasound.
Photo number 6:
o Melanocytic Dermal Naevus
o
o
o
o
The condition which your son has is most likely Squamous Cell
Carcinoma. Typically, it presents as non-healing ulcer in one of a
higher risk sun expose area. Classically, farmers, lower lips, heads
and hands. This tumour can metastasize to lymph nodes. Treatment
is surgical excision. Overall prognosis after treatment is good. (Its
above 95% for 5 year survival) If <1cm: margin of 4mm to deep fat
layer.
Photo number 4:
o Malignant Melanoma
Photos number 2:
o Basal Cell carcinoma
o
o
o
o
Your brother most likely has Basal Cell carcinoma. The most
common type of skin cancer. Its usually occur in people over 35yo.
More frequently in male, fair skin people on sun exposed areas. It
grows slowly over years. Do not metastasis but local spread can
cause problems. Nothing borrows like BCC. Your brother has nodular
BCC with classic pearly appearance. With small dilated vessel near
the surface of the skin. Treatment is surgical excision with atleast
1mm margin.
The most concern is your wifes photo. Its a large lesion with
irregular boarder and pigmentation.
I suspect Malignant Melanoma. Malignant Melanoma is the
most serious condition which can spread locally via lymph
or blood. This lesion must be excised without delay.
Thickness of the melanoma is a major factor determine
prognosis.
4:
Your next patient is a 30-year-old patient old farmer who came for result of biopsy of
a skin lesion which was on the right temporal site.
Features:
Treatment:
excision/cryotherapy
If w/o treatment, 15-20% progress to SCC
Bowen disease
Scaly red plaque w/ clearly defined margins
Not related to sun damage
Treatment:
excision/cryotherapy
Treatment: Wide excision
If lesions <1cm 5mm
If lesion >1cm >5mm
Metastasize to lymph nodes but prophylactic dissection does not give
any advantage
If in the outer sulcus SCC but if lesion inside BCC; if in helix
17x more likely to metastasize (do early wedge resection)
Ulcers of SCC also known as Marjolin ulcer
Hx:
How are you feeling?
o Any pain on the surgical site? John I dont have good news
for you. The result of the biopsy is not what we expected. It
shows that it is a squamous cell carcinoma which is a kind
of a skin cancer. It is a common condition.
Draw diagram:
o Epidermis and dermis. In your case, the epidermis has
started to divide in an uncontrolled manner. The ulcers are
5:
Robert aged 55 years presents to your GP clinic with history of non-healing lesion
on the index finger of his left hand. He tells you he got a small burn while having
barbeque a few months ago. He had applied many ointments and had seen his
usual GP 2-3x but ulcer is not healing. Robert works in a factory and finds it hard to
carry on usual duties due to this wound. Robert is otherwise fit and healthy and lives
independently. He is a heavy smoker and drinks alcohol on weekends with his mate.
Task
Focused history
Physical examination
Differential diagnosis and management advise
Features
Features:
Treatment:
6:
Variant 1:
Thompson aged 54 years presents to your GP clinic with flu-like symptoms. While
you were examining him, you noticed a pigmented lesion on his back. The lesion is
irregular in shape and measures about 1x1.13 cm in diameter. When you tell
Thompson about this lesion, he becomes quite worried and seeks your advice what
to do next.
Task
o Further history
o Examination findings
o Investigations and treatment advise
Variant 2:
A typical picture of melanoma with the report which shows its a superficial
spreading with .4mm in depth. Level two in Clarks classification.
Task
o Explain this condition
o Outline further management plan.
DDx:
Thrombosed hemangioma
Dermatofibroma (button like nodule)
Pigmented seborrheic keratosis
Pigmented BCC
Junctional and compound nevi
Blue nevi
Dysplastic nevi
Lentigines
Features
1/3 of melanomas arise from pre-existing nevus
Most aggressive tumor
Risk factors
Presence of many moles (especially atypical dysplastic nevi)
History of previous melanoma (5x)
Family History
History of many sunburn
Sun-sensitive skin/fair complexion
Age and sex (increasing age and male)
Tanning (solarium treatments)
RED Flags
New or changing lesion
Rapidly growing nodule of any color
o Non-healing lump or ulcer
o ugly duckling syndrome: prominent pigment lesion that
stands out from any other
o Lesion that concerns the patient
o Dermoscopic changes on follow-up or poor dermoscopicclinical correlation
ABCDE:
o Asymmetry
o Border
o Color
o Diameter (mostly more than >5mm )
o Elevation/evolution
o Firm
o Growth pattern in last 4 weeks
Others:
o ulceration or itching;
o development of satellite nodules;
o lymph nodes
Dermatoscope:
o check symmetry,
o meshwork (reticular),
o white and blue structures (skin adhesions)
Biopsy:
o Pigmented lesion: excision biopsy
o Non-pigmented lesion: punch or shave biopsy
Clark
Excision
o Thickness: <1mm (1cm), 1-4mm (1-2cm), >4mm (2cm)
o Level/Depth: <1.5mm (1cm); >1.5mm (2cm)
Breslow
(mm)
0
Involvement
<0.76
95%
1cm
III
0.76-1.5
70-98%
1cm
IV
1.5-4.0
55-85%
2cm
>4mm
Subcutaneous tissue
30-60%
2cm
I (in
situ)
II
Prognosis
Epidermis
Margin Reexcision
5mm
Prognostic indicators:
o Depth of invasion
o Level (epidermis, reticular/papillary dermis, etc)
o Site: head, neck, trunk
o Gender: Male
o Age >50 years
o Amelanocytic melanoma
o Ulceration
5-year Survival rate based on depth:
o 0 mm - very good
o <0.76 mm 95%
o 0.76 1.5mm 70-95%
o 1.51 4mm 55-85%
o >4mm 30-60%
Types:
o Hutchinson melanotic freckle (lentigo maligna)
commonly in elderly; slow-growing intraepidermal lesion
mainly on sun-exposed areas
o Superficial spreading melanoma most common type;
striking color variation; always grows laterally/radially
o
o
Hx:
o
o
o
o
o
o
o
o
o
o
o
o
o
o
Suspicious nevus
Benign nevus
Malignant Melanoma
Dermatofibroma
Mx:
o
o
o
o
Melanoma in-situ/
Lentigo Maligna
>1.5 mm depth
(re-excise up to 2 cm
margin)
(re-exciseto 5mm
margin)
<1.5 mm depth
(Re-excise 1 cm
margin)
7:
You are working in a general practice. You are seeing a 30yo man who works as a
bank teller. He has consulted you about a rash on the extensor surfaces of both
elbows and both knees, over the sternal and lower back areas, and in the scalp. It
first appeared after a motor accident six months ago in which he suffered a fractured
femur. The patient remembers that his father, now deceased, used to be bothered
by a chronic rash.
It has been getting steadily worse over the last few months with some improvement
following the last few months with some improvement following the use of cream
obtained from the local pharmacist (Egopsoryl TA). This has helped the rash on his
body but not on elbows, knees and in the hair.
Examination has revealed the typical lesions of plaque type psoriasis. The plaques
vary in size from a few mm to several cm. They are raised, pink and covered with a
silvery waxy scale. The nails are not affected. The level of severity for this patients
psoriasis should be regarded as moderately severe.
You are about to discuss the disease and its management with the patient. The
photograph shows details of the skin lesions on the knees. Explain the nature of the
condition.
Task
o
o
Draw a picture: Upper part of the skin called epidermis and the lower dermis two
lines are enough
The cells proliferate over here in the epidermis. The vessels dilate
and some inflammation comes at the level of the dermis causing the
skin to become thick (white plaque and scale). The redness is
because of the dilatation of the vessels.
Typical age is 10-60yo. Affects 2-4% of population in Australia.
No lab investigation to diagnose this condition but we can do skin
biopsy if required. There are some general measures and some
drugs can be used.
Any stress, reduce the stress. Stop the drugs and alcohol. Risk
factors? Stop all of them. Sunlight has the protective effect.
The drugs that you can advice the patient:
o Topical steroid. (Main stay of the treatment)
o Dithranol.
o Tar: messy and smelly, staining.
o Calcipotril (Vit D derivative): use with combination.
o Emollients (to protect the irritation of the skin): can use
frequently.
o Keratolytics (soften the scales) salicylic acid.
On the body:
o High potency steroid betamethaxone.
o Dithranol: Causes irritation and burning, staining. Use for
extensive condition
o If there are small plaques that can be mild to moderate:
use intra lesional steroid.
o If the condition is extensive/not responding to the drugs:
Methotrexate/Cyclosporine
It depends how your condition is progressing. If mild or not extensive,
we can start from mild steroid with emollient. If the condition is
getting worse we can change the drugs to high potency.
8:
Variant 1:
A 65-year-old man is in the ED where you are working as HMO, complaining of pain
in his right lower leg for the last 2 days. It is also swollen and feels warm to touch. A
picture of the area is also given.
Variant 2:
George aged 65 years presents to your surgery with his wife Anastasia. He had pain
and swelling of the right leg for a few days due to a fall. Today, his wife noticed that
the swelling and redness has increased and that George had a fever. His wife tells
you he looks quite unwell and had refused his breakfast. George had type 2 DM for
the last 10 years and is on Metformin 1gm BID. He had no other significant medical
or surgical problems. He lives with his wife and is an occasional smoker but drinks
everyday.
Task
o History
(small area of redness in lower limb that has
increased in two days and very painful and
swollen and warm to touch; I was gardening and
I think I injured it but there is no obvious injury)
o Physical examination
(unwell, increased temperature, inguinal LN
palpable and tender, involved area is warm,
swollen, red, and tender to touch; pulses and
sensation normal)
o Diagnosis and management
Features
o Inflammation of subcutaneous tissue
o Cause: streptococcus pyogenes or staphylococcus aureus
o Clinical presentation
o Redness
o Swelling
o Increased temperature
o Pain/tenderness
Risk factors:
o trauma/crack, insect bite, ulcers, may have no signs of
injury
DDx:
o
o
o
o
History:
o
o
o
o
o
o
o
o
o
o
o
o
o
Necrotizing fasciitis
DVT
Pyoderma Gangrenosum
Erythema multiforme
Can you tell me more about it??
Is it painful? How severe is the pain? Painkillers?
Did you injure the legs before this happened?
Did you notice any discharge? Are you able to walk?
Did this happen for the first time?
Do you feel feverish? Any N/V?
Any lumps or bumps in the body?
How is your general health?
Any history of clots in the legs?
Any recent history of long travel or prolonged
immobilization?
Do you have diabetes? Since when? Do you take any
medications?
Peripheral vascular disease? Are you on any medication?
Allergy? SADMA?
Physical examination
o General appearance
o Vital signs
o Lower leg: redness, tenderness, swelling, is the border
elevated or sharply demarcated, regional
lymphadenopathy? Is tenderness disproportional to
examination findings? Lower leg sensation? Vibration?
Pulses and Buerger sign (for PVD)?
Mx:
o You most likely have cellulitis. It is the infection of the skin
in the subcutaneous tissue caused by bugs that can enter
through a break in the skin (S. pyogenes or S. aureus).
o I will admit you to the hospital and arrange surgical
consultation for further management.
o I would like to do some investigation: FBE, inflammatory
markers, blood culture, skin lesion culture and Doppler
ultrasound to rule out DVT.
9:
You are an HMO working in a primary care clinic attached to a teaching hospital.
Your next patient is a 38-year-old man whos consulting you because of hair loss.
One of the eyebrows is also affected. The patient is very concerned about his future,
diagnosis and treatment.
Task
History
o (started 2-3 weeks, path of baldness, stress (+) due to
baldness, affecting performance, having healthy balanced
diet, general health normal; no FHx of baldness)
Diagnosis and Management
DDx:
Alopecia areata
Androgenetic alopecia: (genetic predisposition 20%, gradual,
temporal recession [males] and not central widening; crown loss
[females])
Drug-induced: (anabolic steroids, testosterone, OCPs, danazol,
lithium)
Telogen effluvium acute excessive hair loss 2-3 months after a
stressor whether physical or emotional; self-limiting; 3-6 months;
thinning is all over the scalp
Zinc and iron deficiency
Thyroid eye problems (outer 1/3)
Trichotillomania
Hx:
I understand it is a very distressing situation for you but let me assure
you that we can do a lot of things about it.
Since when did you start having hair loss? Was it sudden or gradual?
Have you lost hair from anywhere else? How about your diet?
Are you taking a healthy balanced diet? Any acne or change in voice? Do you have any weather preferences or mass in your neck? Any
family history of similar conditions?
Are you on any medications like anabolic steroids? SADMA? How is
it affecting your life? Hows your mood? Any change is weight, loss
of appetite? Hows your sleep?
Dx nd Mx:
10:
Nadia, 28 years old presents to your GP clinic complaining of a rash on her nose.
Task
o
o
o
o
Hx
o
History
DDx:
o Eczema
o Tinea of the face
o Cutaneous lupus
Investigations
o Skin scraping (fungal hyphae)
o Fungal culture
o Skin biopsy might be indicated
Management
o Antifungal
o Oral Griseofulvin (not used anymore medical archeology
only), ketoconazole (yes)
o Topical antifungals
o Examine elsewhere to check for primary infection (feet)
o Refer to dermatology.