Table 13-2 Typical Clinical Features of Major Causes of Acute Chest Discomfort
Condition
Duration
Quality
Location
Associated
Features
Angina
More than 2
Pressure,
Retrosternal, often
with radiation to or
10 min
squeezing,
isolated discomfort in
heaviness,
burning
or armsfrequently
on left
Precipitated by
exertion, exposure to
cold, psychologic
stress
Condition
Duration
Quality
Location
Associated
Features
S4 gallop or mitral
regurgitation
murmur during pain
Unstable angina
1020 min
Similar to
Similar to angina
Similar to angina,
angina but
often more
levels of exertion or
severe
even at rest
Similar to
infarction
often more
angina but
than 30 min
often more
Similar to angina
Unrelieved by
nitroglycerin
severe
May be associated
with evidence of
heart failure or
arrhythmia
Aortic stenosis
Pericarditis
Recurrent
Late-peaking
episodes as
for angina
systolic murmur
angina
described for
radiating to carotid
angina
arteries
Hours to
Sharp
Retrosternal or
days; may be
episodic
May be relieved by
sitting up and
leaning forward
Pericardial friction
rub
of unrelenting ripping
radiating to back,
pain
between shoulder
sensation;
Associated with
hypertension and/or
Condition
Duration
Quality
Location
Associated
Features
knifelike
blades
underlying
connective tissue
disorder, e.g.,
Marfan syndrome
Murmur of aortic
insufficiency,
pericardial rub,
pericardial
tamponade, or loss
of peripheral pulses
Pulmonary
embolism
several
minutes to a
Dyspnea, tachypnea,
hypotension
few hours
Pulmonary
Variable
Pressure
Substernal
hypertension
Dyspnea, signs of
increased venous
pressure including
edema and jugular
venous distention
Pneumonia or
Variable
Pleuritic
pleuritis
Unilateral, often
Dyspnea, cough,
localized
fever, rales,
occasional rub
Spontaneous
Sudden
pneumothorax
onset; several
Pleuritic
Lateral to side of
Dyspnea, decreased
pneumothorax
breath sounds on
hours
side of
pneumothorax
Burning
Substernal, epigastric
Worsened by
Condition
Duration
Quality
Location
Associated
Features
postprandial
recumbency
Relieved by antacids
Esophageal
230 min
spasm
Pressure,
Retrosternal
tightness,
burning
Peptic ulcer
Prolonged
Burning
Gallbladder
Prolonged
disease
Burning,
Epigastric, right
pressure
upper quadrant,
substernal
Musculoskeletal
Variable
Aching
Variable
Aggravated by
disease
movement
May be reproduced
by localized pressure
on examination
Herpes zoster
Variable
Sharp or
Dermatomal
Vesicular rash in
burning
distribution
area of discomfort
Emotional and
Variable; may be
psychiatric
be fleeting
retrosternal
conditions
Situational factors
may precipitate
symptoms
Anxiety or
depression often
detectable with
Condition
Duration
Quality
Location
Associated
Features
careful history