GRA 2012 Annual meeting

Inclusive
Innovation
and
Healthcare
Meeting opening

Presidents address

Third Asia Think Tank Summit

Inclusive Knowledge Partnerships for Development
Gerald Hane
Sushil Borde
Raghunath Mashelkar
GRA Colleagues

May 22, 2015

Disclaimer: The views expressed in this paper/presentation are the views of the author and do
not necessarily reflect the views or policies of the Asian Development Bank (ADB), or its Board
of Governors, or the governments they represent. ADB does not guarantee the accuracy of the
data included in this paper and accepts no responsibility for any consequence of their use.
Terminology used may not necessarily be consistent with ADB official terms.

Who we are
The Global Research
Alliance (GRA) is:
a collaboration of eight
of the worlds leading
applied-research
agencies
using the best science
and technology
working to solve some
of the biggest
challenges in the
developing world

GRA Member Organizations

Battelle (USA)

Council of Scientific and Industrial Research (India)

Commonwealth Scientific and Industrial Research Organisation
(Australia)
Danish Technological Institute (Denmark)
Fraunhofer-Gesellschaft (Germany)
SIRIM Berhad (Malaysia)
Netherlands Organisation for Applied Scientific Research
(Netherlands)
VTT Technical Research Centre (Finland)

What we do
The GRAs vision is for a world where the
application of innovative science and technology,
through collaboration and co-creation, delivers
access equality, improves lives and solves global
development challenges.

Our focus
global research for global good

Health

Food

ICT

Water
Energy

Inclusive Innovation GRA approach

Inclusive Innovation is any innovation that leads to
affordable access of quality goods and services
creating livelihood opportunities for the excluded
population, primarily at the base of the pyramid,
and on a long term sustainable basis with a
significant outreach.
Dr Ramesh Mashelkar
GRA President

Getting more, from less, for more

Inclusive Innovation
access equality despite income inequality

Income Inequality 10,000:1

Access Equality 1:1

Inclusive Innovation our philosophy

We undertake:
research for development
Because:
We believe in
Inclusive Innovation

We aspire to build:
Self-reliance
Economic benefits
Social inclusion

Defining the
need and
relevance

by ..

Mobilising
the best
team

Partnering
for impact

Making a
difference

Outline for Today

Growing Capabilites in Advances in Science, Technology and
Innovation Enable a Growing Basket of Inclusive Options
Innovative Technology

Higher performance materials lighter weight, durable,

environmentally sound, low cost

Advanced sensors and diagnostics

Innovative devices

IT to enable broad impact the Internet of things

Innovative Business Models and Market Approaches

Lost cost manufacturing with efficient service workflow

Cost efficient certification for broader markets

Open discovery

Growing Global Interest

World Bank Inclusive Innovation
Organization for Economic Cooperation and
Development (OECD) Innovation for Inclusive
Growth
European Union Horizon 2020 Programme
APEC
Growing number of national aid organizations

VIETNAM INCLUSIVE INNOVATION PROJECT ( VIIP)

THREE PRIORITY THEMES

Traditional Herbal Medicine

Agriculture/Aquaculture

Information/Communication Technology

CHUNG TAY SNG TO PHT TRIN CNG NG

Examples of Inclusive Innovation

Jaipur Foot, Jaipur Knee

$28 Foot
And
$20 Knee

Non-Invasive Blood Test for Anemia

TouchHb
Optical sensor
provides a reading in
60 seconds and
eliminates the need for
needles, lancets,
micro-cuvettes, blotting
paper, etc.
Based on
photoplethysmography,
spectrophotometry,
and photon scattering
software

BLISS4Midwives
Improving maternal health in rural Africa
TNO, Netherlands

Enable integrated diagnostics for

community health nurses and
midwives
Improve therapy tailored to skills,
availability and mandate
Improve referral pathways connecting
CHN, midwives, laboratory and
hospital
Decision
support app

Decentralized point of care

diagnostics of most important
parameters

Robust & ease of use

Concerning 42% of maternal death

causes

Non-invasive
Hb

Anemia

Awareness

User
instructions
Urine strips
- Glucose
- Protein

Gestational
Diabetes

Nutrition
Referrals
Therapy

Commcare
cloud
Blood pressure

BLISS4Midwives

4 May 2015

Preeclampsia

Paper-based Diagnostics and Lab-on-a-Chip

Paper-based diagnostics based

on micro-fluidics

Directs fluids such as blood,

saliva, urine though assay
channels that change colors

Assessment of liver health in 15

minutes

Advanced and Affordable Diagnostics

CSIR - 800 : Affordable Health Care

DNA Based Diagnostic Chip for

Eye infection
Detection of 14 Pathogen causing
ophthalmic infections
Rapid Diagnosis
simultaneously

of

Pathogens

Early treatment of infection to avoid

loss of vision diagnosis within 6 hrs
as against 72 hrs leads to right
prescription

Recognized as the product of the year-2008

and received Asia-Pacific Biotechnology
award (As a product of unmet need)

Micro PCR
Rapid detection of Hepatitis-B Virus
Targeted for deployment at Rural health
care centres and designed for use by
minimally skilled personnel

Patents : US and PCT

Micro PCR would create Global

technological niche

Affordable Infant Warmer

Embrace

Entrepreneurial Design for

Extreme Affordability
Stanford University
Nearly 3 million babies die
every year in the first 28
days within birth. Up to 50%
deaths occur during their
very first 24 hours of life
while 75% occur in the first
week. The 48 hours
immediately following birth
are the most crucial for
newborn survival .
Less than 1 percent the cost
of a conventional infant
incubator.

Safe Surgery Sterilizer

Solarclave

This low-cost, solar-powered

autoclave offers rural health
facilities the ability to sterilize
instruments on-site.

A reflector that concentrates the

suns rays and a pressure
vessel that holds the surgical
instruments and receives the
focused solar energy.

The total cost of materials is

estimated to be US$ 150 with
95% materials sourced locally
(deployment in Nicaragua).

Medical Data Acquisition Unit

ReMeDi

A diagnostic tool that

operates remotely to
capture patient data and
transmit it over a very low
bandwidth (upward of
32Kb/sec).
The devices consume very
little battery power only 2
watts through a USB port
to capture and transmit
each patients vitals such as
blood pressure, heart
sounds, electrocardiograph,
oxygen saturation, and
body temperature.
Deployed in health kiosks in
India.

Innovative Business Model:

Aravind Eye Care
3.3 million eye tests and 300,000 cataract surgeries
per year
Low cost ($5) lens manufacturing joint venture
Extreme efficiency through workflow innovation
Research and training institutes
Civil society groups that organize patient screening
events in rural villages
US$40 cost of treatment
66 percent of patients treated for free

Harnessing Traditional Medicine

Reverse Pharmacology

Argemone Mexicana is a
plant that contains many
alkaloids.
Use clinical experiences and
qualitative experiences to
develop treatment
candidates
No affect on animals,
therefore animal testing
would have been
inconclusive.
Subjects treated and tested
for malaria-causing
parasites in their blood
Substantial decrease seen
over 7 days

Open Source Drug Discovery (OSDD) Model

CSIR led Team India Consortium with International Participation
Open Synthesis and
Exchange
of Knowledge

Candidate
Targets

Lead
Molecules

in silico SCREENING

Mycobacterium tuberculosis

PRECLINICAL &
CLINICAL TRIAL

in vivo VALIDATION

Wiki Portal

Academia
& Hospitals

Exchange of Ideas/Results
Community Participation

Lead Organization
Council of Scientific and
Industrial Research (CSIR), India

Current Partners

Contract
Research
Organisations

Drug

How labs can help

Technology transfer
Capacity building
Country specific analyses
Program design and management

GRA 2012 Annual meeting

Meeting opening

Presidents address

Thank you

Gerald Hane
Battelle Memorial Institute
haneg@battelle.org