SILICON NANOTECHNOLOGIES FOR TRULY

PERSONALIZED HEALTHCARE
RUDI CARTUYVELS

Senior Vice President

Smart Systems & Energy Technologies

THE HEALTHCARE CHALLENGE

350M
Living with
diabetes

12M

36M

new cancer
patients each
year

Living with
Alzheimer
s

17M

132M

deaths from
heart disease
each year

Newborn
babies this
year

IMEC 2014

HEALTHCARE GLOBALLY: KEY DATA

Global Mortality Rate (56MM lives)

Global Healthcare Expenditures* ($T)

$13

Other

30%

Neurology

Cancers

4.8

Respiratory

0.7

Diabetes

6.0

Neurology

$6.3

6%

0.3

+106%

0.9

14%
Cancers

7%
Respiratory

1.0

CVD
23%

Injury

0.5

CVD

18%

2.1
0.5

Infectious Diseases

2.5

2010

2030

*= NON-COMMUNICABLE DISEASES ONLY. SOURCES. WHO,

WEFORUM
IMEC 2014

ENABLING THE NEXT HEALTHCARE

REVOLUTION

BETTER
HEALTHCARE

PREVENTIVE
HEALTH

Chronic disease management

Healthy lifestyle

IMEC 2014

MEDICAL
QUALITY
DATA
IN

CONSUMER
HANDS
ULP
IMEC 2014

Form Factor Affordable

5

IMECS WEARABLES R&D SCOPE

Applicatio
ns
Data
Analytics

IMEC 2014

Systems

Circuits
& Sensors

Technology

IMEC ECG PATCH

Lowest power,
smallest & robust
Ultra-low power ECG &
actimetry measurement
Bluetooth low energy
Embedded artifact
reduction

Accurate rhythm analysis

Activity tracking & energy
expenditure
30 days autonomy

MULTISENSOR DATA FUSION

IMEC 2014

Actimetry Application
Daily summaries
Online Feature extraction and
activity classification
Online personalized energy
expenditure estimation

Motion Artifact Suppression

IMEC 2014

IMEC MULTI-SENSOR MIXED-SIGNAL SOC

World Lowest Power Sensor Hub for Bio-Medical Applications

Analog + DSP + Algorithms = 750uW in total

IMEC 2014

IMEC & SAMSUNG DEVELOP SIMBAND PLATFORM

ECG
HR, HRV
Blood Pressure
Skin Temperature
Actimetry

Based on imecs ULP multisensor SOC & algorithms

http://www.samsung.com/us/globalinnovation/innovation_areas/

IMEC 2014

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NEXT GENERATION ECG: FLEXIBLE PATCH

10 grams
Monitors: Heart Rate,Motion,
skin contact quality
2 days autonomy on 15 mAh flex battery

IMECS LIFE
SCIENCES

In vivo
probes

In vitro
systems

Cyto-metry

Molecular
diagnostics

CELL SORT ER

Si nanotechnology for
personal diagnostics
& therapy

BIOREACTORS

10 mL blood
80 billion red blood cells (~4-6 um)
50 million platelets (~1-2 um)
50 million white blood cells (~8-20 um)
1-100 Circulating tumor cells (~8-24 um)

Need: powerful, low-cost, robust cell inspection tool

that can sort through millions of cells very quickly
adapted from M. Toner

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IMEC CELL SORTER

sorting speed up to 1000 cells/s per channel

fluidic cell sorter on chip
Stroboscopic
Tracing of cells being
sorted

Granulocyte

Lymphocyte Red Blood cell

In flow lensfree imaging

& classification of blood cells
In flow reconstruction of a granulocyte flowing at 1
mm/s

IMEC 2014

15

IMEC ON-CHIP DNA/RNA

DETECTION
Microfluidic silicon platform
Mixers, filters, microreactors

On-chip sample preparation

From drop of blood to purified and amplified DNA

On-chip selective amplification

Fast amplification (9 min)

Multiplex amplification (more fragments in the same reactor)

On-chip detector

A complex
microfluidic Si chip

Dry chemistry

DNA
separation

IMEC 2014

Integration of pumps and valve

with the Silicon chip
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DigInfoTV Feature: DNA testing chip delivers results in one hour, paves
way for personalized drug treatments

http://www.diginfo.tv/v/13-0022-r-en.php

DISPOSABLE CAPILLARY PCR CHIP

Ladder

Actual die

Negative
control
Positive
control
On-chip

imecs lab-on-chip PCR

system using only capillary
forces to actuate fluids
very compact PCR chip

Schematic

Result

IMEC 2014

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EXAMPLE CAPILLARY COMPONENTS

Trigger valve

IMEC 2014

Tooth pump with controlled filling

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PERSONAL HEALTHCARE ENABLED BY

SILICON NANOTECHNOLOGY

IMEC 2014

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IMECS HEALTHCARE R&D PARTNERS

IMEC 2014

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