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6/6/2015

AntidepressantsideeffectsPI

OfficialreprintfromUpToDate
www.uptodate.com.scihub.org2015UpToDate

Chanceofsideeffectswithcertainantidepressantmedicines

Generic
name

US
brand
name

Drymouth
Blurred
vision
Trouble
urinating
Constipation
Dizziness

Trouble

Drowsiness

sleeping
Jitteriness

Nausea
Vomiting
Diarrhea

Selectiveserotoninreuptakeinhibitors(SSRIs)*
Citalopram

Celexa

None

None

Verylow

Verylow

Escitalopram

Lexapro

None

None

Verylow

Verylow

Fluoxetine

Prozac,
Sarafem

None

None

Low

Verylow

Fluvoxamine

Luvox

None

Verylow

Verylow

Verylow

Paroxetine

Paxil,
Pexeva,
others

Verylow

Verylow

Verylow

Verylow

Sertraline

Zoloft

None

None

Low

Low

Wellbutrin,
Aplenzin,
Budeprion,
others

None

None

Quickrelease:
Low

Verylow

Atypicalagents
Bupropion

Sustained
release:Very
low

Mirtazapine

Remeron

Verylow

High

None

None

Serotoninnorepinephrinereuptakeinhibitors(SNRIs)*
Desvenlafaxine

Pristiq,
Khedezla

None

Verylow

Low

Verylow(after
week1)

Duloxetine

Cymbalta

None

None

Low

Low

Milnacipran

Savella

Verylow

Verylow

None

Low

Venlafaxine

Effexor

None

Verylow

Low

Quickrelease:
Low
Extended
release:Very
low

Serotoninmodulators
Trazodone

Desyrel
(onlysold
asgeneric
inUS)

SciHub

None

High

None

Sleepaid
dose:Verylow
Antidepressant
dose:

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AntidepressantsideeffectsPI

Moderate
Vilazodone

Viibryd

None

None

Low

High

Nefazodone

Serzone
(onlysold
asgeneric
inUS)

Verylow

Low

None

Low

*AllSSRIsandSNRIscancausenauseaandstomachupsetatfirstorwhenincreasingdose.Thisusually
goesawayafteraboutaweek.
SertralineismorelikelythanotherSSRIstocausediarrhea.
Trazodonecancauseanerectionthatlaststoolong.Thisisamedicalemergency.
Caution:Cancauseliverfailure.NotavailableinEurope,Canada,andseveralothercountries.
Createdwithdatafrom:
1. LexicompOnline.Copyright19782015Lexicomp,Inc.AllRightsReserved.
2. SerrettiA,ChiesaA.Sexualsideeffectsofpharmacologicaltreatmentofpsychiatricdisease.Clin
PharmTher201189:1427.
Graphic81374Version14.0

Chanceofsideeffectswithcertainantidepressantmedicines,
continued

Genericname

US
Brand
name

Drymouth
Blurred
vision
Trouble
urinating
Constipation
Dizziness

Drowsiness

Trouble
sleeping
Jitteriness

Nausea
Vomiting
Diarrhea

High

High

None

Verylow

Low

Low

Low

None

Tricyclicandtetracyclicantidepressants(TCAs)
Amitriptyline

Elavil
(onlysold
asgeneric
inUS)

Amoxapine

Asendin
(onlysold
asgeneric
inUS)

Clomipramine

Anafranil

High

High

Verylow

Verylow

Desipramine

Norpramin

Verylow

High

Verylow

None

Doxepin

Silenor,

Moderate

Moderate

None

None

Sinequan
Imipramine

Tofranil

Moderate

Moderate

Verylow

Verylow

Maprotiline

Ludiomil

Low

Moderate

None

None

Low

Low

None

None

(onlysold
asgeneric
inUS)
Nortriptyline

Pamelor

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AntidepressantsideeffectsPI

Protriptyline

Vivactil

Low

Verylow

Verylow

Verylow

Trimipramine

Surmontil

High

High

Verylow

None

Monoamineoxidaseinhibitors
Isocarboxazid

Marplan

Verylow

Verylow

Low

Verylow

Phenelzine

Nardil

Verylow

Low

Verylow

Verylow

Selegiline

Eldepryl,

Verylow

None

Verylow

None

Verylow

Verylow

Low

Verylow

Emsam,
others
Tranylcypromine

Parnate

Createdwithdatafrom:
1. NelsonJC.Tricyclicandtetracyclicdrugs.In:TheAmericanPsychiatricPublishingTextbookof
Psychopharmacology,4thed,SchatzbergAF,NemeroffCB(Ed),AmericanPsychiatricPublishing,
Washington,DC2009.p.263.
2. LexicompOnline.Copyright19782015Lexicomp,Inc.AllRightsReserved.
3. SerrettiA,ChiesaA.Sexualsideeffectsofpharmacologicaltreatmentofpsychiatricdisease.Clin
PharmTher201189:1427.
Graphic91671Version4.0

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