Otolaryngology
Head and Neck Surgery
16
American Academy of
OtolaryngologyHead and Neck
Surgery Foundation 2015
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DOI: 10.1177/0194599815584599
http://otojournal.org
Abstract
Objective. To investigate the role of obesity/overweight on
the prognosis of sudden sensorineural hearing loss (SSHL).
Study Design. Retrospective cohort study.
Setting. Outpatient department of a community hospital.
Subjects and Methods. We collected 254 adult patients with
SSHL from a community hospital. The odd ratios of body
mass index (BMI) or obesity/overweight (BMI 25 kg/m2)
on the recovery of SSHL were evaluated with multivariate
logistic regression analysis.
Results. There were 120 (47.2%) patients in the nonobesity
group (BMI \25 kg/m2) and 134 (52.8%) patients in the obesity/overweight group (BMI 25 kg/m2). The complete and
partial recovery rates were 10.0% and 49.2% in the nonobesity group and 9.7% and 47.0% in the obesity/overweight
group, respectively. Univariate logistic regression showed
that BMI had no significant association with recovery of
SSHL (odds ratio [OR] of complete and partial recovery
versus no recovery = 1.04, 95% confidence interval [CI] =
0.965-1.113, P = .327). Multivariate logistic regression analysis also showed that BMI (OR = 1.04, 95% CI = 0.964-1.131,
P = .292) was not significantly associated with the recovery
of SSHL for all subjects, after adjusting for all considered
variables. Also, obesity/overweight (BMI 25 kg/m2) had no
significant association with the recovery of SSHL.
Conclusion. Obesity/overweight would appear to have no significant effect on the prognosis of SSHL.
Keywords
Body mass index, obesity, overweight, sudden sensorineural
hearing loss, prognosis, auditory function
Received September 23, 2014; revised March 3, 2015; accepted April
8, 2015.
1
Department of Otolaryngology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi
Medical Foundation, Chiayi, Taiwan; the School of Medicine, Tzu Chi
University, Hualien, Taiwan
Corresponding Author:
Juen-Haur Hwang, MD, PhD, Department of Otolaryngology, Dalin Tzu Chi
Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan; the School
of Medicine, Tzu Chi University, No. 2 Minsheng Road, Dalin, Chiayi,
62247, Taiwan.
Email: G120796@tzuchi.com.tw
Methods
From 2000 to 2010, well-recorded clinical and audiometric
data of 254 consecutive adult patients with unilateral SSHL
were collected for analysis from the outpatient department
of Dalin Tzu Chi Hospital, Chiayi, Taiwan. The data were
acquired by clinical chart review, and SSHL was documented by clinical diagnosis. Those charts should be maintained
for at least 15 years in Taiwan for legal and medical purposes. The study was approved by the institutional review
board of the Dalin Tzu Chi Hospital, Taiwan (No.
B09902015). Since all of the files contain only de-identified
secondary data, the review board waived the requirement
for obtaining informed consent from the patients.
All patients were treated by 4 physicians with a standard
treatment protocol. The decision to admit or not admit was
based on the patients will but was not based on age,
gender, disease severity, and so forth. Age, gender, BMI,
presenting symptoms, time elapsed from onset of SSHL to
initial treatment, admission or not, and medical history,
including coronary artery disease (CAD), HTN, DM, dyslipidemia, and CKD, were recorded. In addition, data of
pure-tone audiometry were collected.
All included patients were divided into 2 groups based
on BMI as defined by the World Health Organization in
2014. The nonobesity group was defined as patients with a
BMI \25 kg/m2, whereas the obesity/overweight group was
defined as patients with a BMI 25 kg/m2. Those patients
who were not admitted for treatment received the outpatient
protocol: oral prednisolone (1 mg/kg per day for 7 days, and
then tapered within 14 days), nicametate (50 mg, 3 times a
day), and aspirin (100 mg, once a day). In addition, those
patients who were admitted for treatment received the inpatient protocol: intravenous dexamethasone (10 mg per day
for 7 days, and then tapered within 14 days by oral prednisolone), intravenous 10% dextran 40 (twice a day for 7
days), oral nicametate (50 mg, 3 times a day), and aspirin
(100 mg, once a day).
Exclusion criteria included age younger than 18 years,
external or middle ear diseases, conductive hearing loss
Statistical Analysis
The data were presented as means 6 standard deviation
(SD), unless indicated otherwise. Continuous variables were
compared by Student t test, whereas categorical variables
were compared by x2 test. The odds ratio (OR) and BMI on
the recovery of SSHL, which was shown as complete and
partial recovery versus no recovery, or good and moderate recovery versus no recovery, were first evaluated
with univariate a logistic regression analyses for all subjects.
Then, we included the variables whose P value was .4 in
the univariate logistic regression into the multivariate logistic regression model for all ages, age younger 65 years, and
age older than 65 years, because the prognosis might vary
in different age groups.16 In addition, in each analysis, age
was regarded as a continuous variable. P values \.05 were
considered statistically significant. All analyses were performed using STATA 10.0 software (Stata Corp, College
Station, Texas). The power calculation was performed by
the free software G-Power (http://www.gpower.hhu.de/).
Results
There were 109 (42.9%) female patients and 145 (57.1%)
male patients in this study. The mean age was 54.9 6 14.2
years (range, 18-88 years) for all 254 patients. The mean
BMI was 24.9 6 4.1 kg/m2 (range, 15.8-42.1 years).
Table 1 showed the general characteristics of all subjects
by BMI. There were 120 (47.2%) patients in the nonobesity
Hwang
Nonobesity Group
(BMI \25 kg/m2)
Obesity/Overweight
Group (BMI 25 kg/m2)
P Value
120 (47.2)
55.2 6 14.7
42.5/57.5
6.0 6 4.6
55.4 6 23.7
39.1 6 25.4
134 (52.8)
54.7 6 13.8
43.3/56.7
5.9 6 5.8
52.6 6 23.1
36.8 6 25.6
.7888
1.000
.9674
.3414
.4755
40.8
49.2
10.0
74 (61.7)
3 (2.5)
43 (35.8)
36 (30.0)
16 (13.3)
9 (7.5)
28 (23.7)
8 (6.7)
43.3
47.0
9.7
61 (45.5)
5 (3.7)
47 (35.1)
38 (28.4)
19 (14.2)
6 (4.5)
43 (32.2)
18 (13.6)
.949
.012
.726
1.000
.784
.858
.425
.248
.200
Abbreviations: BMI, body mass index; CAD, coronary artery disease; CKD, chronic kidney disease; DM, diabetes mellitus; F, female; HTN, hypertension; M,
male; SD, standard deviation; SSHL, sudden sensorineural hearing loss.
a
The initial or treated hearing loss severity was the audiometric difference between the affected ear and nonaffected ear.
Discussion
In this retrospective cohort study, we have provided new
evidence about the role of obesity/overweight on the recovery of SSHL in adults. In SSHL patients without receiving
ITS, BMI or obesity/overweight was not significantly and
Table 2. Univariate Logistic Regression Analysis for the Recovery of SSHL for All Subjects.
Age, y
Gender (males vs females)
BMI, kg/m2
Time elapsed from onset of SSHL to initial treatment, d
Initial hearing loss severity, dB HL
Admission
CAD
HTN
DM
Dyslipidemia
CKD
Vertigo
Headache
OR
SE
P Value
95% CI
0.98
1.31
1.04
1.00
1.02
1.37
5.30
0.65
1.10
0.84
1.49
1.01
3.18
0.009
0.336
0.038
0.028
0.006
0.350
5.707
0.173
0.308
0.309
0.839
0.340
2.089
2.46
1.05
0.98
0.17
3.03
1.24
1.55
1.61
0.33
0.46
0.71
0.02
1.76
.014
.295
.327
.862
.002
.215
.121
.107
.743
.644
.480
.982
.078
0.959-0.995
0.791-2.163
0.965-1.113
0.942-1.051
1.006-1.029
0.832-2.262
0.642-43.734
0.388-1.096
0.633-1.900
0.412-1.730
0.494-4.490
0.520-1.953
0.877-11.528
Abbreviations: BMI, body mass index; CAD, coronary artery disease; CI, confidence interval; CKD, chronic kidney disease; DM, diabetes mellitus; HTN,
hypertension; OR, odds ratio; SE, standard error; SSHL, sudden sensorineural hearing loss.
a
OR was calculated from the odds of the combined complete and partial recovery versus no recovery.
All Subjects
OR (95% CI)
Age, y
0.99 (0.965-1.013)
OR (95% CI)
1.25 (0.684-2.276)
1.39 (0.676-2.866)
1.04 (0.964-1.131)
1.01 (0.911-1.120)
1.01 (0.999-1.027)
1.01 (0.996-1.028)
0.88 (0.462-1.674)
0.71 (0.318-1.589)
3.92
HTN
.227
(0.427-36.000)
0.63 (0.327-1.231)
.178
.308
1.13 (0.330-3.861)
.846
1.15 (0.981-1.352)
.084
1.02 (0.985-1.048)
.317
1.43 (0.428-4.757)
.563
1.54
.750
.160
.696
CAD
1.06 (0.949-1.181)
.852
.065
Admission
.370
.292
Initial hearing loss severity, dB HL
OR (95% CI)
.148
.471
BMI, kg/m2
0.97 (0.937-1.010)
.345
Gender
Age 65 y
.406
Omitted
0.63 (0.275-1.445)
.276
(0.106-22.416)
0.63 (0.182-2.173)
.464
Abbreviations: BMI, body mass index; CAD, coronary artery disease; CI, confidence interval; HTN, hypertension; OR, odds ratio; SSHL, sudden sensorineural
hearing loss.
a
OR was calculated from the odds of the combined complete and partial recovery versus no recovery.
Statistically, hearing level was in fact a continuous variable but was arbitrarily defined into a category variable for
outcome calculation. Second, treatment protocols might
contribute variably to the treatment outcomes. Thus, the
contradictory results between these articles mentioned
above and ours might be due to the differences in the outcome definition and/or treatment protocols.12-24 In addition, the merit of this study over other published similar
studies is that we have proposed a novel possible factor
(obesity/overweight) on the prognosis of SSHL, although a
negative result was shown.
Hwang
Conclusion
In this retrospective cohort study, we found that BMI or
obesity/overweight was not significantly associated with the
recovery of SSHL without ITS. Additional prospective,
well-designed studies about WC and the prognosis of SSHL
Author Contributions
Juen-Haur Hwang, accountability for all aspects of the work.
Disclosures
Competing interests: None.
Sponsorships: None.
Funding source: None.
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