1963
311
By
D.
H.
DOLPHIN
and A. W.
JOHNSON
STUDIES
OH 2
(A)
-}
-SR
-}
Colli -~ COlli
Me
COlli
([I)
observed that the rate of reaction of hydroxocobalamin, sodium sulphide, and methyl iodide to form
methylcobalamin is faster in the absence of oxygen
(10-6 mm.) than the similar reaction with oxygen
present. The precise nature of the oxidation step has
not been elucidated. The cycle is reversed when the
final solution is irradiated, as methylcobalamin is
rapidly photolysed to re-form hydroxocobalamin.
-SR
OH 2
Colli
""
NaHS
fMe
Mel
COII _ _ ~
(III)
lI
Me
Collj _ _ ~Colli
hv
312
PROCEEDINGS