CD2 T cell marker (although CD3 is more common), marker of systemic mastocytosis
CD3 most specific T cell antibody; diminished expression in T cell cutaneous lymphoma
CD4 classify lymphomas and inflammatory conditions; serum levels are marker of HIV
disease progression and response to therapy (CD4+ cells are killed by HIV); serum levels
also increased by transient stress
CD5 marker for CLL, mantle cell lymphoma, T cells (normal and malignant), thymic
carcinoma
CD6 Antibodies to CD6 are used to deplete T cells from bone marrow transplants to
prevent graft versus host disease
CD8 cytotoxic T cell marker
CD10 = CALLA
Acute lymphoblastic leukemia (ALL):
Angioimmunoblastic T cell lymphoma:
Breast: marker of myoepithelial cells
Burkitts lymphoma:
Diffuse large cell lymphoma:
Ectopic prostate:
Endometrial stromal tumors:
Endometriosis:
Follicular lymphoma:
Gynecologic tumors:
Hemangioblastoma
CD11c histiocytic marker, NK cell marker, diagnosis of hairy cell leukemia (with other
markers)
CD13 myeloid marker
CD14 mature monocytes/macrophages
CD15 Hodgkins lymphoma
CD16a NK cell and macrophage marker; to subtype leukemia/lymphoma
CD19 Earliest B cell antigen in fetal tissue
CD56 Also called N-CAM (neural cell adhesion molecule) Uses: marker for NK cells
and NK lymphomas; differentiates plasma cells in myeloma (CD56+) from reactive
plasmacytosis or MGUS
CD57 Uses: marker of NK cells and neuroendocrine tumors
CD61 Uses: identify platelets, megakaryocytes, platelet thrombi; distinguish TTP from
DIC
CD62P heparin-induced thrombocytopenia
CD63 marker of melanoma (although non-specific) and melanocytic tumors
CD64 high neutrophil CD64 levels predict sepsis
CD65 myeloid antigen
CD66e Also called CEA, carcinoembryonic antigen HOPE ALL KNOW THE USES
CD71 Also known as transferrin receptor Uses: high serum levels can diagnose hemolytic
anemia
CD79a Uses: general detection of B cells/B cell origin (with CD20); also
- in ALL or small B cell lymphoproliferative disorders when CD20 may be negative or
after rituximab (anti CD-20) therapy
CD79b Uses: distinguish CLL from other B cell disorders if intensity of staining is
considered
CD83 marker for activated dendritic cells
CD90 Also called Thy-1 Uses: hematopoietic stem cell marker
CD95 Also called Fas, Apo-1, TNF receptor superfamily member 6, TNFRSF6
Cell surface membrane receptor that activates apoptotic pathways when bound by Fas
ligand (FasL, CD178
CD99 relatively non-specific marker for Ewings sarcoma and T cell lymphoma, but does
distinguish Ewings from neuroblastoma
CD103 marker for hairy cell leukemia, intraepithelial lymphocytes (normal or tumor)
CD105 specific and sensitive marker for tumor angiogenesis
CD107b cardiomyopathy due to Danons disease
CD117 GIST