1. posthypoxic,
2. spinal,
3. and postencephalitic myoclonus (Genton and Gelisse
2000; Krauss et al 2001; Keswani et al 2002).
Progressive myoclonic epilepsy may be worsened by phenytoin
(Eldridge et al 1983).
Acetazolamide may be helpful in myoclonus of Ramsay Hunt
syndrome.
Essential myoclonus
- often responds to alcohol
- and may be improved by anticholinergics (Chokroverty et al
1987).
Palatal myoclonus is usually resistant to therapy, but in some
cases,
1. anticholinergics (Jabbari et al 1989),
2. 5-hydroxytryptophan (Magnussen et al 1977),
3. and carbamazepine (Sakai et al 1981) have been helpful.
Spinal myoclonus may respond to
1. removal of compressing lesion (Daniel and Webster 1984)
2. and effective drugs have included clonazepam and
tetrabenazine (Jankovic and Pardo 1986) 4limbs=tetrabenaz.
Negative myoclonus
1. often resolves with the correction of the responsible metabolic
derangement,
2. and ethosuximide may be particularly useful in the symptomatic
treatment (Shirasaka and Mitsuyoshi 1999). Several data have
demonstrated the effectiveness of ethosuximide in the
treatment of epileptic negative myoclonus in children suffering
from idiopathic partial epilepsy (Oguni et al 1998; Capovilla et al
1999; 2000; Shirasaka and Mitsuyoshi 1999; Kubota et al
2005). These evidences have suggested that this drug,
specifically acting as T-type Ca2+ blocker on thalamic neurons
and related cortical assemblies, may modulate at the thalamo-