UROKINASE DOSE WHEEL PROPOSAL FOR BSVL

DETAILS OF DELIVERABLES
Type of input: Dosage wheel or dosage card
Title of the input: Urokinase in clinical Practice A Ready Reckoner
Periodicity: One-time input
Input details:
Dose wheel - B5 size; printed on both sides; with a pivot for
rotating the dose flaps to get the correct dosage for the
indication; 4-color job
Dosage card B5 size; printed on both sides; 4-color job
Target customers: Doctors
Molecule: Urokinase
Indications: Acute myocardial infarction, deep vein thrombosis,
pulmonary embolism, pleural effusion
Contents: The dosage wheel/dosage card will incorporate the dose of
urokinase in different conditions and the details of administration
route of administration, if dilution is needed, rate of administration, any
need for concomitant therapy etc.

MEDICCA PRESS A MEDICAL CONTENT COMPANY

UROKINASE DOSE WHEEL PROPOSAL FOR BSVL

Sample contents for the dose wheel / dosage card

Indication
Myocardial
infarction

Dosage of urokinase
Systemic administration

1 to 2 million IU
Doses up to 3 million
IU have been used to
treat acute myocardial
infarction (AMI)

Administration

Administered IV
once over 15 to 30
minutes

Concomitant therapy

Direct intracoronary
artery infusion:

Pulmonary
Embolism

Deep Vein
Thrombosis

Pleural
effusion

Average total dose of

500,000 IU
Alternate dose - at a
rate of 6000 IU /min for
up to 2 hours, at a rate
of 20,000 to 25,000
IU/min for 10 to 20
minutes, up to a total
dose of 250,000 to
500,000 IU
Initial: 4400 IU/kg
ideal body weight
(IBW)

Infused into the

occluded artery at a
rate of 6000 IU /min for
up to 2 hours

Urokinase should be given following heparin bolus

Heparin therapy (without a loading dose) is

recommended when the thrombin time has
decreased to less than twice the normal control
value.

Heparin therapy (without a loading dose) is

recommended when the thrombin time has
decreased to less than twice the normal control
value

Their use may be most beneficial in high risk

patients of an older age or with co-morbidity where
surgery has a greater risk.

Maintenance: 4400
IU/kg (IBW) /hour

Initial: 4400 IU/kg

ideal body weight
(IBW) Maintenance:
4400 IU/kg (IBW) /hour

100,000 IU

Prior to beginning urokinase, a bolus of heparin

2500 to 10,000 units IV once should be given
Prior heparin administration should be considered
when calculating the heparin dose
Heparin therapy (without a loading dose) is
recommended when the thrombin time has
decreased to less than twice the normal control
value

Administered as
an IV bolus over
10 minutes
Administered as a
continuous IV
infusion for 12
hours
Administered as
an IV bolus over
10 minutes
Administered as a
continuous IV
infusion for 72
hours
Intrapleural
administration,
once a day for 3
days

MEDICCA PRESS A MEDICAL CONTENT COMPANY