Positive Effects of Proviron

Overview
Proviron, the brand name for mesterolone, is a synthetic type of male sex hormone. Mesterolone, chemically
known as 1-methyl-5?-dihydrotestosterone (DHT), is methylated (the addition of a methyl group CH3)
making it an active steroid very similar to natural DHT that does not convert into estrogen or progesterone
(both female hormones) once in the body. Proviron has many positive effects on the body, including
increasing muscle mass, enhancing testosterone levels and treating male sexual dysfunction.
Testosterone Enhancer
Proviron on its own is considered to be a weak steroid according to a study by A.T. Kicman published in the
British Journal of Pharmacology. However, it has unique properties that make it a useful and effective
enhancer, especially of testosterone. In normal levels in the body, testosterone is mostly inactive because most
of it is bound by sex hormone binding globulin (SHBG) and albumin. Proviron also has a great affinity for
SHBG, so when administered, it will bind to the SHBG, leaving more testosterone free.
Increase Muscle Density
The increase in free testosterone can then mediate anabolic activities, including protein synthesis, which in
turn
increases
muscle
gain.
Estrogen is only active and effective when bound to estrogen receptors. Proviron decreases the ability of these
estrogen receptors, found in the muslces, to bind to estrogen, therefore decreasing the amount of active
estrogen. In addition, Proviron has an affinity for the aromatase enzyme, which is the enzyme in the body that
binds with testosterone and converts it to estrogen. When Proviron binds to the enzyme, it blocks testosterone
from binding, therefore reducing the amount of estrogen produced. These effects result in a decrease in water
buildup in the body, which gives the muscles a leaner, harder look.

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Impotence Treatment
Impotence, also referred to as erectile dysfunction, is the inability to achieve or maintain an erection. One of
the causes of impotence is a low level of testosterone. Proviron, as dicussed in the section above, has the
ability to enhance testosterone, which can then relieve the symptoms of impotence.
Infetility Treatment
Male infertility, or sub-fertility, is often caused by a problem with the production of sperm. Although the full
mechanism of male fertility is not yet understood, it is known that the production of sperm is dependent upon
both androgens (like testosterone) and gonadotrophins which are the hormones that stimulate the sexual
organs. Androgens have been used to treat infertility problems, but they often decrease gonadotropin
secretion,
making
it
ineffective
for
inducing
sperm
production.
Proviron stimulates androgens while having little to no effect on the gonadotrophins, according to a study
conducted by Patrick Bye and published in the Postgraduate Medical Journal. Proviron, therefore, is a
desirable candidate to treat some male infertility and more studies continue to be conducted.
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