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Earliest lesions of degenerative joint disease are microscopic alterations of articulr cartilage. Changes include diminution of metachromatic material, decreased numbers of chondrocytes. Changes in synovial membranes, including fibrosis, hypertrophy, and synovitis are secondary.
Earliest lesions of degenerative joint disease are microscopic alterations of articulr cartilage. Changes include diminution of metachromatic material, decreased numbers of chondrocytes. Changes in synovial membranes, including fibrosis, hypertrophy, and synovitis are secondary.
Earliest lesions of degenerative joint disease are microscopic alterations of articulr cartilage. Changes include diminution of metachromatic material, decreased numbers of chondrocytes. Changes in synovial membranes, including fibrosis, hypertrophy, and synovitis are secondary.
The earliest lesions of degenerative joint disease are microscopic alterations of
articulr cartilage. These include diminution of metachromatic material, decreased numbers of chondrocytes, fatty degeneration, alteration of collagen fibrils, and surface irregularities. Later morphologic changes include localized softening of the cartilage with surface flaking and fibrillations. Abrasion of fibrillated cartilage results in progressive loss of cartilaginous surfacing and exposure of subchondral bone. Subsequent to ulcerations of cartilage, new bone formation occurs at the margin of articular cartilage. These marginal osteophytes are represented in roentgenograms as the characteristics spurs. Other asseous changes include cysts of varying size beneath the joint surface and remodeling of subhondral bone. Changes in synovial membranes, including fibrosis, hypertrophy, and occasionally synovitis appear to be secondary to events affecting articular cartilage. FIGURE DIFFERENTIAL DIAGNOSIS In their typical expressions, degenerative joint disease and rheumatoid arthritis are easily distinguished. The latter is usually associated with evidence of systemic disease, prominent signs of joint inflammation, and the characteristics symmetrical pattern of disease affecting the hands and wrists. When a patient presents with signs of mild inflammation in one or two weight-bearing joints of the lower extremities, the differentiation between these two syndromes is more difficult. In the setting a normal erythrocyte sedimentation rate, negative rheumatoid factor test result, and minimal abnormalities is synovial fluid support the diagnosis of degenerative joint disease. A common diagnostic error is the interpretation of degenerative changes in proximal interphalangeal joints of the hands as evidence of rheumatoid arthritis (Fig.2B). The deformities that characterize Heberdens and Bouchards nodes may be marked, but this pattern of degenerative joint disease is usually not associated with prominent signs of inflammation, and the metacarpophalangeal joints and wrist joints are rarely or never affected. Important aspects of differential diagnosis involve the recognition of syndromes in which secondary development of degenerative joint disease may occur. These include hemochromatosis, neuropathy, chondrocalcinosis, alcaptonuria, hypermobility of joints (including the Ehlers-Danlos syndrome). There should never be confusionin the differentiation of degenerative joint disease of the vertebral column from ankylosing spondylitis. Patients with the later are almost
invariably young men, and the roentgenographic features are distinct from those associated with degenerative joint disease.