Schematic Diagram of Stroke

Due to thrombosis or embolism, some

neurons die because of lack of oxygen and
nutrients

Impaired cerebral tissue perfusion

(Hemorrhagic)

Infarction of the Cerebral Vessels

known as Stroke

Tissue injury triggers an

inflammatory response
which increases intracranial
pressure

Space- occupying blood clots

put more pressure on the
brain tissues.

The injury disrupts

metabolism leading to
changes in ionic transport,
localized acidosis, and free
radical formation

The regulatory mechanisms

of the brain attempt to
maintain equilibrium by
increasing BP and ICP.

Calcium, sodium, and water

accumulate in the injured
cells and excitatory
neurotransmitters are
released

The ruptured cerebral vessels

may constrict to limit blood
loss however; this vasospam
will result to further ischemia
and necrosis of brain tissues.

Continued cell cellular injury

and swelling both occurs
resulting to further cell
damage

Brain Death