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Guyton, Arthur C. Hall, John E. 2007. Buku Ajar Fisiologi Kedokteran Edisi 11. Jakarta: EGC.
Prince, Sylvia A., & Wilson, Lorraine M. (2005). Patofisiologi: Konsep Klinis Proses-proses Penyakit, Edisi 6, Vo

Departemen Kesehatan. Survei kesehatan nasional. Laporan Departemen Kesehatan RI. Jakarta. 2004.
Badan Penelitian Dan Pengembangan Kesehatan Kementerian Kesehatan RI. Riset Kesehatan Dasar Riskesdas. 20
Ng Kuan Huei, Stanley Adrian G, Williams Bryan. Hypertension : Pathogenesis, Risk Factors And Prevention, Els
Intharachatorn Thida & Srisawat Rungrudee. 2013. Antihypertensive Effects of Centella asiatica Extract. Internati
DOI: 10.7763/IPCBEE.

Matsubara T, Bohgaki T, Watarai M, Suzuki H, Ohashi K, Shibuya H. 1999. Antihypertensive Actions of Methylri
Medicinal Plant. Biol Pharm Bull.1999 Oct;22(10):1083-8.

Mak-Mensah E E, Komlaga G, Terlabi E O. 2010. Antiypertensive Action of Ethanolic Extract of Imperata cylindr
pp. 1486-1491, 18 July, 2010.

Oktriana Nurul Huda, Nurlaela. Toksisitas Pemberian Berulang Infusa Pegagan (Centella Asiatica (L.) Urb.) Pada
Prosiding Seminar Nasional Sains dan Teknologi Ke-2 2011, 55-60

Chunlaratthanaphorn Siharat, et al. Acute and subchronic toxicity study of the water extract from root of Imperat
Vol.29 . 141-155

Badan POM RI - Direktorat Obat Asli Indonesia 2008.

Pramono, S. 1992. Profil Kromatogram Ekstrak Herba Pegagan yang Berefek Antihipertensi. Warta TOI Vol 1(2)
Zainol, N.A., Voo, S. C., Sarmidi, M. R. and Aziz, R. A. 2008. Profiling of Centella asiatica (L.) Urban extract. T

Zheng, C. J. and Qin, L.P. 2007. Chemical Components of Centella asiatica and Their Bioactives. Journal of Chin

Qin, L. P., Ling, R. X., Zhang, W. D. et al. 1998. Essential Oil from Centella asiatica and Its Antidepressant Activi
187.

Sakshi Singh, Asmita Gautam, Abhimanyu Sharma & Amla Batra. 2010. Centella asiatica (l.): A Plant with Imme
Sciences Review and Research. Volume 4, Issue 2, September October 2010; Article 003.

Hashim, P. 2011. Centella asiatica in Food and Beverage Applications and Its Potential Antioxidant and Neuropr

Andria, Yulianti. 2012. Pengaruh Pemberian Ekstrak Daun Pegagan (Centella Asiatica (L) Urban) Terhadap Kad
Norvegicus) Betina. Januari 2012.

S. Muangnongwa. Effect of expressed juice of fresh Centella asiatica (L) URBAN leaves on cardiovas
University, Thailand, 2004.

Hashim Puziah, et al. 2011. Triterpene Composition and Bioactivities of Centella asiatica, Molecules 2011, 16, 13

Roopesh Chitrala, et al. Diuretic Activity of Methanolic and Ethanolic Extracts of Centella asiatica Leaves in Rat
2230-8407.
Chin-Lin Hsu, Bo-Han Hong, Yu-Shan Yu & Gow-Chin Yen. 2010. Antioxidant and Anti-Inflammatory Effects of
58 (4), pp 21502156.

Swarna Jayakumar & Ravindhran Ramalingam. 2013. Influence of Additives on Enhanced In vitro Shoot Multipli

Raesuchel,L. Florida Exotic Pest Plant Council. Diakses dari www.fleppc.org pada tanggal 3 Januari 2

Diakses dari http://diperta.jabarprov.go.id/index.php/subMenu/informasi/artikel/detailartikel/250 www.fleppc.org

The Global Biodiversity Information Facility: GBIF Backbone Taxonomy, 2013-07-01. Diakses dari http://www.g

Setyowati, F.M. 2010. Etnofarmakologi dan Pemakaian Tanaman Obat Suku Dayak Tunjung di Kalimantan Timu
Nomor 3 Tahun 2010 10 4.

Windadri, F.I. 2000. Alang-alang (Imperata cylindrica (L.) Raeuschel). Dalam: Sutarno,H. dan S. Atmowidjojo (P
Lingkungan. Prosea Indonesia-Yayasan Prosea, Bogor. Seri Pengembangan Prosea 12(1).2: 35-37.

Krishnaiah D., Devi T., Bono A. & Sarbatly R. 2009. Full Length Research Paper: Studies on Phytochemical Con
Research Vol. 3(2), pp. 067-072, February, 2009.
Gamal A. Mohamed , et all. 2009. Chemical Composition and Hepato-Protective Activity of Imperata cylindrica

Ruslin, et al. Anti-Hypertensive Activity of Alang-alang Imperata cylindrica (L.) Beauv. Root Methanolic Extract o

Boos CJ et al. Circulating endothelial cells in cardiovascular disease. J. Am. Coll. Cardiol 2006; 48: 1538-1547
ChristoWoywodt A, Bahlmann FH, de Groot K, Haller H, Haubitz M.Circulating end othelial cells: life, death and
30.pher

Anne Margreet De Jong, Alexander H. Maass, Silke U. Oberdorf-Maass, Dirk J. Van Veldhuisen, Wiek H. Van Gi
caused by stretch occurring before and during early atrial fibrillation. Cardiovascular Research (2010) 89, 7547

Sripanidkulchai Bungorn, et al. Diuretic effects of selected Thai indigenous medicinal plants in rats, Journal of E

Panagiotis Berilis. The Role of Collagen in The Aortas Structure. The Open Circulation and Vascular Journal, 201
Ross Michael H., Pawlina Wojciech. 2001. Histology A Text and Atlas 6th Ed. Philadelphia: Lippincott Williams a
Dorlands Illustrated Medical Dictionary, 27th ed., WB. Saunders, 1988 : 556

Luscher TF, Barton M. Biology of the endothelium. Clin. Cardiol.1997; 20 Suppl 2:3-10
Cooke JP. Therapeutic interventions in endothelial dysfunction: endothelium as a target organ. Clin Cardiol. 1997;
Kadirvelu A, Chee KH, Chim CL. Endothelial dysfunction in cardiovascular diseases. Med. Progr. 2002 : 4-12
Sowinski KM. Endothelial function and dysfunction. Report of the American College of Clinical Pharmacy 2000 A

Goligorsky MS, Gross SS. The ins and outs of endothelial dysfunction : much a do about NO-thing. Drug New Pe
Tortora Gerrard J, Derrickson Bryan H. 2009. Principles of Anatomy and Physiology : Maintenance and Continuit

Yasunobu hirata and Hiroshi satonaka. 2001. Hypertension and Oxidative Stress. Journal of the Japa

Jean Davignon and Peter Ganz.2004. Role of Endothelial Dysfunction in Atherosclerosis. Journal of t
formatnya cz de expert opinion tak lampirkan jurnalnyaa.

Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation. 2002; 105: 11354
Oparil Suzanne, Zaman M Amin, Calhoun David A. Pathogenesis of Hypertension, Ann Intern Med. 2
Atlas Steven A. The Renin-Angiotensin Aldosteron System : Pathophysiological Role and Pharmacolo
Erdbruegger U, Haubitz M, Woywodt A. Review: Circulating endothelial cells: A novel marker of endothelial dam
School, Carl-Neuberg-Strasse 1, D-30625 Hannover, Germany. Elsevier: U. Erdbruegger et al./Clinica Chimica A

Grosjean J, Kiriakidis S, Reilly K, Feldmann M, Paleolog E. Vascular

Riri Jonuarti . 2013. Analisis Aliran Darah dalam Stenosis Arteri Menggunakan Model Fluida Casson dan Power
Elizabeth J. Corwin. 2009. Buku Saku Patofisiologi. Edisis 3. Jakarta: EGC.

Panagiotis Berilis. 2013. The Role of Collagen in The Aortas Structure. The Open Circulation and Va

Kumar V., Robbins S. L. & Cotran R. S. 2007. Buku Ajar Patologi 2. Edisi 7. Jakarta: EGC.
Peters, Stephen R. 2010. A Practical Guide to Frozen Section Technique. University of Medicine and Dentistry of
Sheehan D. & Hrapchak B. 1980. Theory and Practice of Histotechnology. 2nd Edition. pp 189-190, Battlle Press,

Bancroft J. & Stevens A. 1982. Theory and Practice of Histological Techniques. 2nd Edition. pp 131-135, Churchi
Luna L. 1968. Manual of Histological Staining Methods of The AFIP. 3rd Edition. pp 94-95, McGraw-Hill, NY.
Carson F. 1990. Histotechnology A Self-Instructional Text. 1st Edition. pp 142-143, ASCP, III.

Crookham & Dapson. 1991. Hazardous Chemicals in The Histopathology Laboratory. 2nd Edition. An

Beevers Gareth , Y H Lip Gregory, O'Brien Eoin. ABC of hypertension. The Pathophysiology Of Hypertension. B

Lopez Farre Antonio, Casado Santos. Heart Failure, Redox Alterations, and Endothelial Dysfunction. Hypertensio
Dallas, TX 75231. 2001.

Mc.Cance L. Kathryn, Huether E. Sue, Brashers L. Valentina, Rote S. Neal. Pathophysiology The Biologic Basis f
Goldman Lee. Md, Cecil Medicine . 2007. 23rd Edition

De Jong Anne Margaret, H. Mass Alexander, Oberdort.Mass Silke U, Van Veldhuisen, Van gilst. Mechanisms of a
atrial fibrillation. Cediovascular Research. 2010. 754 756

Wiyono. 2003. Pengaruh Pemberian Vitamin E terhadap Kadar Malondialdehid Pada Pengidap Diabetes Melitus T
No 1.

Bagiada, N.A. 2001. Proses Penuaan dan Penanggulangannya. Denpasar: Fakultas Kedokteran. Universitas Uday
Soeatmaji, D.W. 1998. Peran Stres oksidatif dalam Patogenesis Angiopati Mikro dan Makro DM. Medica 5 (24). H
Goldman, R., Klatz. 2003. The New Anti-Aging Revolution. Australasian Edition. Theories of Aging. p. 22-24, 19
Droge W. Free radicals in the physiological control of cell function. Physiol Rev. 82;2002:47-95.
Suryohudoyo, P. 2000 . Kapita Selekta Ilmu Kedokteran Molekuler. Perpustakaan Nasional RI. Jakarta :Penerbit C
Winarsi, H. 2010. Antioksidan Alami & Radikal Bebas. Potensi dan Aplikasinya dalam Kesehatan. Cetakan ke-4.

Tohru Fukai et al. 2002. Extracellular superoxide dismutase and cardiovascular disease. Department of Medicine,
Atlanta, GA 30322, USA. Elsevier

Kadiiska MB, Gladen BC, Baird DD, et al. Biomarkers Oxidative Stress Study II : Are Oxidation Products Of Lipi
2005;38 (6): 698-710.

Siswonoto S. Hubungan Kadar Malondialdehid Plasma dengan Keluaran Klinis Stroke Iskemik Akut. Universitas
Polidori MC, Cherubini A, Ruggiero C, Mecocci P. Potensial Marker Of Oxidative Stress In Stroke. Free Radic B
Azzimondi G, et al. Plasma Lipoperoxidative Markers In Ischemics Stroke Suggest Brain Embolism. Eur J Emerg
Edyson. Pengaruh Pemberian Kombinasi Vitamin C dan E terhadap Kadar Malondialdehyde (MDA) pada Eritrosi
2003. Vol. 5, No. 3

Ave, S Maryland. Hydrogen peroxide regulation of endothelial function: Origins, mechanisms, and consequences.

Lu, Deshun. Role of shear stress and stretch in vascular mechanobiology. J. R. Soc. Interface. 2011
Deanfield, John E. Endothelial Function and Dysfunction: Testing and Clinical Relevance. American Heart Assoc
Yang, Yang-Ming. eNOS uncoupling and endothelial dysfunction in aged vessels. Am J Physiol Heart Cirs Physio
H. Sonnenberg & A. Mabsden-Potter. 1973. Proximal and Distal Tubular Function in Salt-Deprived and in Salt-L
Investigation Volume 52.

J. Mitchell & D. F. Bohr. 1983. Mechanism of Mineralocorticoid-induced Hypertension. International Boehringer

Grobe Justin L, et al. Angiotensinergic Signaling in the Brain Mediates Metabolic Effects of Deoxycorticosterone
Hypertension. 2011;57:600-607.

Ooshima Akira, et al. Increased Collagen Synthesis in Blood Vessels of Hypertensive Rats and Its Reversal by Ant
1974
Yemane Henok , et al Neurohumoral Mechanisms in Deoxycorticosterone Acetate (DOCA)Salt Hypertension in

Imenshahidi Mohsen, et al. Effects of chronic crocin treatment on desoxycorticosterone acetate (doca)-salt hypert

Yasunobu hirata and Hiroshi satonaka. 2001. Hypertension and Oxidative Stress. Journal of the Japa

Yasunobu hirata and Hiroshi satonaka. 2001. Hypertension and Oxidative Stress. Journal of the Japa
xx . Yasunobu hirata and Hiroshi satonaka. 2001. Hypertension and Oxidative Stress. Journal of the
1579.44.

Jean Davignon and Peter Ganz.2004. Role of Endothelial Dysfunction in Atherosclerosis. Journal of t
formatnya cz de expert opinion tak lampirkan jurnalnyaa.