The University of Medical Sciences and Technology

Faculty of Medicine
Research Methodology Department
M.B.B.S. Proposal
Project Supervisor:
Name: Dr. Nazik Elfadil Abdullah
Position: Professor of ENT, Khartoum University
Address: Khartoum E.N.T hospital
Telephone number: +249912161944
E-mail: nazikfad1223@yahoo.co.uk
Student:
Name: Israa Amr Abdelrahman Elhakeem
Batch number and year of admission: Batch 18, 2011
Student index number: MD-2011-176
Telephone number: +249908084395
E-mail: Israa_965@hotmail.com

Project Title
Extent of impact of Allergic Rhinitis, on quality of life amongst UMST students

Anticipated outcome:
References
contddecrease of QOL in those with at least one symptom of allergic rhinitis.
Methodology:
-A significant
12.Leynaert
B, of
Neukirch
C,congestion
Liard
R. Quality
of highest
life
inanalytical
asthma.Am
J
1. expected
Type
study
(e.g.
prospective,
amongst
etc): and
and
relevant
publications
last
5allergic
years): rhinitis
-It is Introduction
also
that
nasal
willretrospective,
be(within
the
complaint
those
with allergic
1 May 2015).
Respir
Care
Med. 2000;162(4):1392-1396
(accessed
29
Cross-sectional
study
Mini rhinitis.
RQLQ
2 alone,
In page
the Crit
US
allergic
rhinitis affects at least 50 million
people
and according to recent
13.
Bousquet
J.,
Khaltaev
N.,
Cruz
A.
A.,
Denburg
J.,
Fokkens
W.
J.,
Togias A.
et al. Allergic
2.
Study
population
and
sample
size:
studies
by
World
Allergy
Association
it
affects
10%
to
30%
of
the
worlds
population,
with Rhinitis
-Nasal and
eye):symptoms will be amongst the highest complaints.
Appendices
(
if
any
2 Sciences
- its
The
University
ofImpact
Medical
and
Technology,
Khartoum
and
its ofincreasing
on rhinitis
Asthma
(ARIA)
2008;
63():
.
prevalence
.disturbance
Allergic
is defined
as
inflammation
of
nasal mucosa,
-Total
percentage
emotional
will
be
considerably
lower than2008.
all the
symptoms.
- due
Estimated
sample
size
=response
385 students.
tobetween
an IgE
mediated
when
subject
is exposed
to certain
allergens. Although
http://onlinelibrary.wiley.com/doi/10.1111/j.1398-9995.2007.01620.x/abstract
(accessed 29 May
-A relation
sleep
disturbance
and
difficulty
because
of the symptoms.
Appendix
1- miniRQLQ
(questionnaire)
Page
1sleep level=
-Margin
of
error
(E)
=
+
/5%,
Confidence
95%
hence
Z
=1.96,
Standard
Deviation=
seen as a trivial
disease,between
allergic male
rhinitis
impairs the quality of life due
to its 0.5
-No2015).
considerable
difference
andundoubtedly
female results
2
2
- common
Calculated
by:
Z the
Li,
(1)
/Jin,
E Lijuantype
symptoms
and
associations.
Apart
classical
symptoms
such asal.nasal
-Mild
to severe
will
be
most
prevalent
offrom
allergic
rhinitis
14.
Yingshen
Lu,
Shuai
Hui
Song,
Yanmei
Li, Nanshan
Zhong,et
High nasal resistance
3
Note:
sample
size
cannot
be
considered
completely
accurate
until
population
of campus
is
obstruction,
hyaline
rhinorrhea
and
sneezing
;
AR
also
increases
the
risk
factor
for asthma,
References:
may be a result rather than a cause of obstructive sleep apnea. 2014; 271(11)
obtained
innasal
the
next
academic
year when the study
willwith
take place.
sinusitis,
polyposis,
conjunctivitis,
media
upper
respiratory
Allergy
Facts.
http://acaai.org/news/facts-statistics/allergies
(accessed
28
May 2015). 18(6)(): .
15. J1.
Mullol,M
Maurer,
J Bousquet.otitis
Sleep
and effusion,
Allergic
Rhinitis.2008;
3.
Data
collection:
infections,
breathing through
the mouth, and more frequently, sleep disorders4.
2.
Allergy Statistics.
http://www.aaaai.org/about-the-aaaai/newsroom/allergy-statistics.aspx
http://www.researchgate.net/profile/Marcus_Maurer/publication/23758473_Sleep_and_allergic_rhini
-Use
of miniRQLQ
official
questionnaire
(2-3 minutes)
as it is problems,
more timeand
sufficient
andsocial
concise
Consequently
suffer
from sleep disorders,
emotional
impaired
(accessed
28patients
may
2015).
tis/links/0fcfd5081532c9cbf8000000.pdf
(accessed
1
June
2015).
5
6
rather
than the. Quality
official
RQLQ
questionnaire
(12-15
minutes)
(see
appendix
functioning
ofCristina,
life (QOL)
wellbeing
and satisfaction
ofof1)
life
; health3.
Camelo-Nunes
Ins
Solsignifies
Dirceu.
Allergic
rhinitis:
indicators
quality
of life. and
J.
16. Muhammed
Zahid,
Salahuddin
Ayubi.
Effect
of
topical
steroids
on
mucociliary
clearance
-The
study
population
will
consist
of
both
genders.
Individuals
will
be
informed
of
theand
studies nasal
related
quality
of
life
(HRQOL)
is
a
branch
of
QOL
that
deals
with
the
health
aspect
bras. pneumol.score
[Internet]. 2010
Feb [cited
2015 June rhinitis.
01] ; 36(
1 ): 124-133.18(12)():
Available
symptom
in perception
allergic
2011;
.
aim
the dataas
collecting
process
before handed
the questionnaire.
If consent
is obtained,
canand
be defined
the individuals
on their
physical, social,
emotional
and social
from:
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806questionnaire
will
be
provided
http://applications.emro.who.int/imemrf/Professional_Med_J_Q/Professional_Med_J_Q_2011_18_2
well being. In order to asses such aspects specific validated questionnaires were developed.
37132010000100017&lng=en
http://dx.doi.org/10.1590/S1806-37132010000100017.
-Mini
Rhinoconjunctivitis
questionnaire
is the
questionnaire
in this study.
In the
case of(accessed
allergic rhinoconjunctivitis,
the validated
disease-specific
questionnaire
most It consists
_289_294.pdf
1 June
2015).
4.
1.
Ruby
Pawankar,
Giorgio
Walter
Canonica,
Stephen
T.
Holgate,
Richard
F. 4, 7eye
ofcommonly
14 questions
in
5
domains
(activity
limitation,
practical
problem,
nose
symptoms,
used is the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ)
.
Lockey.other
WAOsymptoms,
White Book
on Allergy
2011-2012:Executive
symptoms,
practical
problems).
Questionnaire isSummary;
based on a2011.
6 point scale (0=
8
no
impaired).
The mean
of developed
all 14 responses
is in
used
calculate
http://www.worldallergy.org/publications/wao_white_book.pdf
(accessed
29toMay
2010).the
It impairment
was
not untiland
the6=severely
past 20 years
that researchers
had
interest
creating
studies
11
miniRQLQ
score
.
5.
quality ofbetween
life questionnaire
(RQLQ).
thatRhinoconjunctivitis
focused on the relationship
allergic rhinitis
and its burden on quality of life.
- In
There
will
also
be
an
additional
question
regarding
the
specific
timedata
scale
of recorded
the candidates
ahttp://www.qoltech.co.uk/rqlq.html
prospective, cross sectional survey(accessed
from 5 European
countries,
was
from
28 may 2015).
allergic
rhinitis
as
the
miniRQLQ
is
only
based
on
symptoms
in
the
past
week.
1482
patientsG.
and
according
to J.,
theScadding
mini rhinoconjuctivits
quality
6.
Canonica
W.,assessed
Bousquet
J., Mullol
G. K. and Virchow
J. of
C..life
A survey of
4.
forof
analysis:
questionnaire.
Itdata
showed
81.8% of
some impairment
of their daily life as a
the Plan
burden
allergic
rhinitis
in patients
Europe..reported
2007; 62(s85):
.
6
Data
will
be
analyzed
by
comprehensive
computer
software
known
as
SPSS
(statistical
package
result
of their Allergic rhinitis . Using RQLQ and the short version questionnaire
(SF-36),
http://onlinelibrary.wiley.com/doi/10.1111/j.1398-9995.2007.01549.x/citedby
(accessed
for
socialand
sciences).
UOEH
other hospitals in Japan observed 126 patients with allergic rhinitis. There was a
28 May
2015).
5.
Ethical
consideration:
downgrade in the
RQLQ scores for each symptom, most significantly in nasal obstruction10.
7.
Bousquet
J.,
Khaltaev
N., Cruz A. A., Denburg
J., Fokkens
W.atJ.,University
Togias A. of
et al.
Allergic
-ItIts
will
be 40
sought
ethical
by sleeping
the research
board
Medical
been
yearsfrom
since
Cottleconfirmation
suggested that
patterns
are in great measure
Rhinitis
and
its Impact
on Asthma
14, 15(ARIA) 2008. 2008; 63(): .
sciences
andon
technology.
dependent
good
nasal function
. Without control of the symptoms of allergic rhinitis,
-Permission
must besleep
obtained
from
the University
of Medical
sciences
and fatigue
technology.
http://onlinelibrary.wiley.com/doi/10.1111/j.1398-9995.2007.01620.x/full
(accessed
28 as
there
is increased
loss or
disturbance
consequently
causing
daytime
and Then
this
study
approaches
students
in
their
studying
environment,
it
is
essential
to
ask
permission
May
2015).
decrease functioning. Using Epworths sleepiness scale, a controlled cross sectional study,
from
their
lecturer/doctor/professor;
followed
by
explanation
of
the study
in a simple
8.
M.
Elkholy,
Mahmoud
Hassan
Khedr,Ashraf
Halawa,
Elbaramawy.
Impact
on Maha
591
patients
by Leger
et al showed
43.7%
of an
allergic
rhinitisAyman
patients
reported
a feeling
15
manner.
of fatigue
on awakening
normal
nights
sleep
show 2012;
this could
be .
of Allergic
Rhinitis ondespite
Qualitya of
Life in
Patients
with. Relationships
Bronchial Asthma.
6(2)():
Plan
ofnasal
investigation
(How?
): abnormal breathing during sleep16
due6.
to
partial
congestion
causing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616948/ (accessed 27 May 2015).
-Investigation will be carried out by using the official miniRQLQ, 14 questions, 5 domains
9. Mansoureh Shariat, Zahra Pourpak,Mojtaba Khalesi,Anoshirvan Kazemnejad, Laleh
which
are activity&, practical problems, eye, nose & other symptom. Answers are based on a 7
Justification:
Sharifi,Golnoosh
Souzanchi,
et6=severely
al. Quality impaired).
of Life in the Iranian Adults with Allergic
point
scale an
(0=assessment
no impairment
HRQOL,
manyand
clinicians
do not acknowledge is in fact a fundamental
Rhinitis.
2012;
11(): . http://ijaai.tums.ac.ir/index.php/ijaai/article/viewFile/556/408
-Mean
of each
questionnaire
be obtained
from
their 14 responses.
approach
to improve
qualitywill
of care
in patients,
especially
with diseases which are referred
(accessed
28
May
2015).
-Percentage
the as
total
amount
of each
beascalculated.
to as trivialof
such
Allergic
rhinitis.
It symptom
is diseaseswill
such
allergic rhinitis which have a
10.
Shiomori
T,of
Udaka
K,ones
Fujimura
T, Hiraki
N,because
Ueda
N,they
et al.
of
-Separate
gender
percentage
of results
in total
amount
of each
symptom
will
be calculated
higher
chance
beingT,a Hashida
burden
on
lifestyle
simply
areEvaluation
not
-Calculation
of
the
types
of
allergic
rhinitis:
mild,
moderate-severe,
persistent
and
intermittent
quality of life
in patients
with allergic
rhinitis.
2007;individuals
(): .
appropriately
managed
and often
neglected.
Allowing
to asses themselves based
(see
appendix
2)
on http://www.ncbi.nlm.nih.gov/pubmed/17582988
a functional questionnaire will give us an idea on(accessed
the extent29which
May allergic
2015). rhinitis really
7.
Time
plan (Gantt
):insight by statistical
11.
affects
Ferda
individuals.
BLGR,
Papatya
It willchart)
give
BAYRAK
us(When?
a clear
DERMENC,
Rabia Bilge
evidence
ZGL,
whichBahadr
aspects,DEDE,
See
Appendix
3
whether
social,
emotional,
physical
etc,
are
more
negatively
impacted
by
allergic
rhinitis.
Cengiz KIRMAZ. Our results on SF-36 quality of life scale in patients diagnosed
with
8.
Budget:
Thus
potentially
help
us
move
one
step
forward
in
understanding
the
severity
of
the
disease
drug allergy.Arastirma Research Article 2013; 11(): .
Questionnaires:
and even a new approach on how to manage these problems.
http://www.aai.org.tr/managete/UploadedFiles/2013-02/2013-11-2-112-117.pdf
(accessed
Quantity-250,
Price- 0.40SDG = 100 SDG total
29 May 2015).
Hypothesis
(if any):
There will be a significant decrease in Quality of life in patients with allergic rhinitis,
specifically the moderate-severe type.
2

Appendix 2 Allergic Rhinitis Classification

Appendix 3- Gantt chart

Certificates
I/we confirm that I/we shall control and be actively engaged in the day to day management
and conduct of the study and be responsible for all occurrences including safety of persons
engaged in the project and the proper use of laboratory animals.
Signature of Project Supervisor

Date

I confirm that the project outline above has not already been or is currently being submitted
for any other qualifications in this or other University of Institution.

Signature of Research Methodology Coordinator

(For office use only)

Project Number:

Date of Submission:

Date