Hodgkin's lymphoma.

Symptoms

Painless swelling of lymph nodes in your neck, armpits or groin

Persistent fatigue

Fever and chills

Night sweats

Unexplained weight loss as much as 10 percent or more of your body weight

Loss of appetite

Itching

Increased sensitivity to the effects of alcohol or pain in your lymph nodes after
drinking alcohol

Causes

occurs when an infection-fighting cell (B cell) develops a DNA mutation

cells divide rapidly.
large number of oversized, abnormal B cells to accumulate in the lymphatic system,
o -crowd out healthy cells

Types
Classical Hodgkin's lymphoma

common

large, abnormal cells called Reed-Sternberg cells in their lymph nodes.

Subtypes

o Nodular sclerosis Hodgkin's lymphoma

o Mixed cellularity Hodgkin's lymphoma
o Lymphocyte-depleted Hodgkin's lymphoma

o Lymphocyte-rich classical Hodgkin's lymphoma

Lymphocyte-predominant Hodgkin's lymphoma

large, abnormal cells that are sometimes called popcorn cells

Risk factors

age. 15 and 30, > 55.

f hx of lymphoma.

sex. Males

Past Epstein-Barr infection.

weakened immune system. HIV/AIDS or from having an organ transplant

(requiring medications to suppress the immune response)

Tests and diagnosis

Physical exam. swollen lymph nodes, including in your neck, underarm and
groin, spleno/hepatomegaly

Blood tests.

Imaging tests. X-ray, CT scan, PET

Surgery to remove a swollen lymph node. Minor surgery

bone marrow biopsy

Stages of Hodgkin's lymphoma include:

Stage I. The cancer is limited to one lymph node region or a single organ.

Stage II. two lymph node regions or the cancer has invaded one organ and the
nearby lymph nodes. But the cancer is still limited to a section of the body either
above or below the diaphragm.

Stage III. When the cancer moves to lymph nodes both above and below the
diaphragm ; one portion of tissue or an organ near the lymph node groups or in the
spleen.

Stage IV. in several portions of one or more organs and tissues. Affects other
parts of your body, such as the liver, lungs or bones.
Categories:

A = no significant symptoms as a result of the cancer.

B = significant signs and symptoms (persistent fever, unintended weight loss or
severe night sweats)

Complications
Pancytopenia (deficiency of all three cellular components of the blood (red
cells, white cells, and platelets)
Nausea
infection

Treatments

Chemotherapy (se: nausea and hair loss; complications: heart damage, lung
damage, fertility problems and other cancers, such as leukemia. )
Radiation (skin redness and hair loss, fatigue during; heart disease, stroke, thyroid
problems, infertility and other forms of cancer, such as breast or lung cancer)

Stem cell transplant replace BM