Anda di halaman 1dari 386

Essential

drugs
Practical guidelines

intended for physicians, pharmacists,


nurses and medical auxiliaries

2013 EDITION

Mdecins Sans Frontires February 2013


All rights reserved for all countries. No reproduction, translation and adaptation may be done
without the prior permission of the Copyright owner.
ISBN 2-906498-91-2

Essential drugs
Practical guidelines
Editorial committee:

Jacques Pinel (Ph), Franoise Weiss (Ph), Myriam Henkens (MD)


and Vronique Grouzard (N, general editor)
Contributors:

S. Balkan (MD), F. Baud (MD), V. Boissire (Ph), M.E. Burny (N), F. Chappuis (MD),
A.S. Coutin (MD), E. Da Costa (Ph), C. Danet (MD), K. Dilworth (MD), F. Drogoul (MD),
F. Fermon (N), N. Harris (MD), E. Lasry (MD), X. Lassalle (AA), C. Mac (Ph), R. Murphy (MD),
B. Renchon (Ph), J. Rigal (MD), M. Schaefer (MD), M. de Smet (MD), J. Stassijns (MD),
E. Szumilin (MD), F. Varaine (MD), C. Zen Ruffinen (Ph).
We would like to thank C. Boissinot (Ph), M. Boussinesq (MD), A. Certain (Ph), F. Delange (MD),
P.Y. Fournier (MD), S. Gnamien (Ph), B. Graz (MD), C. Gurin (Ph), C.A Jeanne-Rose (Ph),
J. Van Roey (MD) for their invaluable contributions to this guide.

(MD) Medical doctor, (Ph) Pharmacist, (N) Nurse, (AA) Anaesthetist-assistant

Translated from French by V. Grouzard, N. Harris and C. Lopez-Serraf.


Design and layout: Evelyne Laissu

Preface
The 1978 Alma Ata Conference on primary health care recognized that essential drugs are
vital for preventing and treating illnesses which affect millions of people throughout the
world. Essential drugs save lives and improve health.
In 1981, the World Health Organization established the Action Programme on Essential
Drugs to support countries to implementing national drug policies and to work towards
rational use of drugs. This work was broadened in 1998 when WHO created the department
of Essential Drugs and Other Medicines (EDM), combining the responsabilities of the former
DAP with WHO's global efforts to promote quality, safety, efficacy, and accurate information
for all medicines.

EDM works with countries, international agencies, NGOs like Mdecins Sans Frontires,
and other organizations to ensure that people everywhere have access to the essential drugs
they need at a price which is affordable; that the drugs are safe, effective, and of good quality;
and that they are prescribed and used rationally.
Appropriate tools are critical to the effective implementation of essential drugs policies. This
practical handbook, based on Mdecins Sans Frontires' field experience, is one of the tools
which we strongly recommend.

Designed to give practical, concise infomation to physicians, pharmacists and nurses, this
Essential drugs - practical guidelines is an important contribution from Mdecins Sans
Frontires to improve the rational use of drugs, which will be a continuing challenge in the
coming years.
Dr Jonathan D. Quick
Director,
Essential Drugs and Other medicines
World Health Organization

Foreword
This guide is not a dictionary of pharmacological agents. It is a practical
manual intended for health professionals, physicians, pharmacists, nurses and health
auxiliaries involved in curative care and drug management.

We have tried to provide simple, practical solutions to the questions and


problems faced by medical staff, using the accumulated field experience of
Mdecins Sans Frontires, the recommendations of reference organizations such as
the World Health Organization (WHO) and specialized documentation in each field.
This manual is not only used by Mdecins Sans Frontires, but also in a wide
range of other programmes and contexts.

The list of drugs in this edition has been revised: in accordance to the most
recent WHO list of essential medicines, certain drugs have been added, others have
been removed.

Among the entries in this guide, some are not listed in the WHO list of essential
medicines. However these drugs are in the same pharmaceutical class for which the
WHO has named only one "example of a therapeutic group" preceded by a square
symbol to indicate that various drugs can be used as alternatives.
Certain medicines, which are not on the WHO list, are still frequently
administered although their use is not recommended. These medicines have been
included in this guide by entries marked by a grey diagonal line.

The entries are classified according to the route of administration and in


alphabetical order. This classification reflects the drug management system proposed
in this manual (see Organization and management of a pharmacy, page 297).
Only the main contra-indications, adverse effects, precautions and drug
interactions of each drug have been indicated in this manual. For further detailed
information refer to specialised literature. Concerning antiretrovirals, the interactions
are too many to be listed: it is therefore essential to refer to specialised literature.
This manual is a collective effort by medical professionals from many
disciplines, all with field experience.

Despite all efforts, it is possible that certain errors may have been overlooked in
this manual. Please inform the authors of any errors detected. It is important to
remember, that if in doubt, it is the responsibility of the prescribing medical
professional to ensure that the doses indicated in this manual conform to the
manufacturer's specifications.
The authors would be grateful for any comments or criticisms to ensure that
this manual continues to evolve and remains adapted to the reality of the field.
Comments should be addressed to:

Mdecins Sans Frontires - Guidelines


8 rue St-Sabin - 75011 Paris
Tel.: +33.(0)1.40.21.29.29
Fax: +33.(0)1.48.06.68.68
e.mail: guide.essdrugs@msf.org

This manual is also available on the internet at www.msf.org. As treatment protocols


are constantly changing, medical staff are encouraged to check this website for
updates of this edition.

Use of the guide


General organisation

There are two easy ways to find information in this manual:

A summary at the beginning of the manual lists the chapters and their
corresponding pages.
A double-entry alphabetical index at the end of the manual with international nonproprietary and proprietary names.

Nomenclature of drugs

The International Non-proprietary Names (INN) of drugs is used in this manual.


Some frequently used proprietary names, followed by the symbol , are also given.
E.g.: amoxicillin (Amoxyl, Clamoxyl)

Dosage

Prescription tables showing average dosage in drug units (tablets, ampoules etc.)
according to weight or age of patients are included for the most commonly used
drugs.
Dosage for children are expressed in milligrams per kilogram per day (mg/kg/day)
for most drugs. For certain symptomatic drugs, dosage is expressed in milligrams
per kilogram per dose (mg/kg/dose). For certain antiretrovirals, dosage is expressed
in milligrams per square meter (mg/m2).

Dosage for adults is expressed in grams or milligrams per day for most drugs. For
certain drugs requiring a more precise dosage, doses are expressed in mg/kg/day. In
malnourished patients, prescriptions should always be adapted to the patient's
weight.

Symbols

This box indicates potentially toxic drugs,


Prescription under medical supervision administered under medical prescription only
in many European countries (e.g. Belgium,
France, Spain, UK).

Revised April 2014

This symbol is used to draw attention to drugs


whose toxic potential is greater, or for which
experience has shown they are frequently
misused.
Drugs marked with a grey diagonal line are
either potentially dangerous and forbidden
in certain countries, or obsolete or ineffective.
These drugs are still widely used, attention is
therefore drawn to the risk of their prescription.

Practical recommendations for drug storage:


drug very sensitive to light

drug very sensitive to humidity

If no temperature for storage is recommended, this indicates that no information was


found in medical literature.

Abbreviations
kg
g
mg

Units

= kilogram
= gram
= milligram
(1 g = 1000 mg)
g
= microgram
= square meter
m2
IU
= international unit
M
= million
mEq = milliequivalent
mmol = millimole
ml
= millilitre
(1 cc = 1 ml)
tsp
= teaspoon (= 5 ml)
ssp
= soupspoon (= 15 ml)

Administration route
IM
IV
SC

= intramuscular
= intravenous
= subcutaneous

Presentation

tab
cap
vl
amp
susp

Others

v/v = volume in volume


D = day
(e.g. D1 = first day)

= tablet
= capsule
= vial
= ampoule
= suspension

Summary
PART ONE

10

Oral drugs

Injectable drugs

page 155

Infusion solutions

page 231

Vaccines, immunoglobulins and antisera

page 241

Drugs for external use, antiseptics and disinfectants

page 259

page 13

PART TWO
Organisation and management of a pharmacy

page 297

Drug quality and storage

page 309

Prescription, cost, compliance

page 313

Use of antibacterials

page 317

Antiseptics and disinfectants

page 323

WHO model list of essential medicines

page 329

Main references

page 367

Alphabetical index

page 368

11

Oral drugs

Abacavir (ABC)
Acetaminophen
Acetylsalicylic acid (ASA)
Aciclovir
Activated charcoal
Albendazole
Albuterol
Albuterol aerosol
Albuterol nebuliser solution
Aluminium hydroxide
Amitriptyline
Amodiaquine (AQ)
Amoxicillin
Amoxicillin/clavulanic acid
Artemether/lumefantrine
Artesunate (AS)
Artesunate/amodiaquine (AS/AS)
Artesunate + sulfadoxine/pyrimethamine
Ascorbic acid
Aspirin
Atenolol
Azithromycin
AZT/3TC
AZT/3TC/NVP
Beclometasone
Biperiden
Bisacodyl
Butylscopolamine
Cabergoline
Calcium gluconate
Carbamazepine
Cefalexin
Cefixime
Charcoal (activated)
Chloramphenicol
Chloroquine
Chlorphenamine = chlorpheniramine
Chlorpromazine
Cimetidine
Ciprofloxacin
Clindamycin
Clomipramine

Cloxacillin
Co-amoxiclav
Coartemether
Codeine
Colecalciferol
Cotrimoxazole
d4T/3TC/NVP
Dapsone
Desogestrel
Diazepam
Didanosine (ddI)
Diethylcarbamazine
Digoxin
Dihydroartemisinin/piperaquine
Dipyrone
Doxycycline
Efavirenz (EFV - EFZ)
Enalapril
Ergocalciferol
Erythromycin
Ethambutol (E)
Ethinylestradiol/levonorgestrel
Ferrous salts
Ferrous salts/folic acid
Fluconazole
Flucytosine
Fluoxetine
Folic acid
Folinic acid
Fosfomycin tromethamine
Furosemide = frusemide
Glibenclamide
Glyceryl trinitrate
Griseofulvin
Halofantrine
Haloperidol
Hydrochlorothiazide
Hyoscine butylbromide
Ibuprofen
Indinavir (IDV)
Iodized oil
Isoniazid (H)

Isosorbide dinitrate
Itraconazole
Ivermectin
Labetalol
Lactulose
Lamivudine (3TC)
Levodopa/carbidopa
Levonorgestrel
Levonorgestrel (emergency)
Loperamide
Lopinavir/ritonavir (LPV/r)
Mebendazole
Mefloquine (MQ)
Metamizole
Methyldopa
Metoclopramide
Metronidazole
Miconazole
Mifepristone (RU486)
Misoprostol
Morphine immediate-release
Morphine sustained-release
Multivitamins
Nalidixic acid
Nevirapine (NVP)
Niclosamide
Nicotinamide
Nifedipine
Nitrofurantoin
Nitroglycerin
Noramidopyrine
Nystatin
Omeprazole
Oral rehydration salts (ORS)
Paracetamol
Paroxetine
Penicillin V
Phenobarbital
Phenoxymethylpenicillin
Phenytoin
Potassium chloride immediate-release
Potassium chloride sustained-release
Praziquantel
Prednisolone and prednisone
Promethazine

Pyrantel
Pyrazinamide (Z)
Pyridoxine
Pyrimethamine
Quinine
ReSoMal
Retinol
Rifampicin (R)
Risperidone
Ritonavir (RTV)
Salbutamol
Salbutamol aerosol
Salbutamol nebuliser solution
Saquinavir (SQV)
Sodium valproate
Spironolactone
Stavudine (d4T)
Stavudine/lamivudine/nevirapine
Sulfadiazine
Sulfadoxine/pyrimethamine (SP)
Sulfamethoxazole/trimethoprim
Thiamine
Tinidazole
Tramadol
Tranexamic acid
Triclabendazole
Trinitrin
Valproic acid
Vitamin A
Vitamin B complex
Vitamin B1
Vitamin B3
Vitamin B6
Vitamin B9
Vitamin C
Vitamin D2
Vitamin D3
Vitamin PP
Zidovudine (AZT - ZDV)
Zidovudine/lamivudine
Zidovudine/lamivudine/nevirapine
Zinc sulfate

ABACAVIR = ABC
(Abac, Abamune, Ziagen)

Prescription under medical supervision

Therapeutic action

Antiretroviral, HIV-1 and HIV-2 nucleoside reverse transcriptase inhibitor

Indications

HIV-1 or HIV-2 infection, in combination with other antiretroviral drugs

Presentation

300 mg tablet
20 mg/ml oral solution, with oral dosing syringe

Dosage

Child less than 25 kg: 16 mg/kg/day in 2 divided doses, without exceeding 600 mg/day
Child 25 kg and adult: 600 mg/day in 2 divided doses
Weight

20 mg/ml oral solution

300 mg tablet

10 to 13 kg

6 ml x 2

3 to 5 kg
6 to 9 kg

14 to 19 kg
20 to 24 kg
25 kg

3 ml x 2
4 ml x 2

Duration: depending on the efficacy and tolerance of abacavir.

1/2

tab x 2

1 tab AM and 1/2 tab PM


1 tab x 2

Contra-indications, adverse effects, precautions

Do not administer to patients with severe hepatic impairment or history of severe intolerance
to abacavir that led to discontinuation of treatment.
May cause:
hypersensitivity reactions: skin rash, gastrointestinal disturbances (nausea, vomiting,
diarrhoea, abdominal pain), cough, dyspnoea, malaise, headache, lethargy, oedema,
lymphadenopathy, hypotension, myalgia, arthralgia, renal impairment;
lactic acidosis and hepatic disorders.
In all these cases, stop taking abacavir immediately and permanently.
Pregnancy: avoid, except if there is no therapeutic alternative

Remarks

Tablets are not scored. When half a tablet is required, use a cutter or a tablet cutter to cut
the tablet into two equal parts.
Also comes in fixed-dose combination tablets containing abacavir-lamivudine (Epzicom,
etc.) and abacavir-zidovudine-lamivudine (Trizivir, etc.).
Storage: below 30C
Once opened, oral solution kept below 30C may be stored for a maximum of 2 months.

15

ACETYLSALICYLIC acid = ASPIRIN = ASA


Therapeutic action

Analgesic, antipyretic, non steroidal anti-inflammatory (NSAID)

Indications

Mild pain
Fever
Rheumatic diseases (except gout)

Presentation

100 mg and 500 mg tablets. Also comes in 300 mg tablets.

Dosage

Pain and fever


Child: 60 mg/kg/day in 3 or 4 divided doses
Adult: 1 to 3 g/day in 3 or 4 divided doses

AGE

WEIGHT

100 mg tablet

500 mg tablet

300 mg tablet

1 year

2 months

4 kg

5 years

8 kg

15 kg

1 1/2 tab x 3
1/2
1/4

tab x 3
tab x 3

Rheumatic diseases
Child > 20 kg: 50 to 100 mg/kg/day in 4 divided doses
Adult: 3 to 6 g/day in 4 divided doses

15 years

3 tab x 3

35 kg

1 tab x 3

1/2

tab x 3

ADULT

2 tab x 3

1 tab x 3

Maximum dose: child: 100 mg/kg/day; adult: 6 g/day

Duration: pain and fever: 1 to 3 days; rheumatic diseases: according to clinical response.
Contra-indications, adverse effects, precautions

Do not administer to patients with allergy to aspirin and NSAID, peptic ulcer, coagulation
disorders, haemorrhage; severe renal, hepatic or cardiac impairment.
Do not administer to children under 1 year (use paracetamol).
Administer with caution to elderly patients or patients with asthma.
Do not exceed indicated doses, particularly in children and elderly patients. Intoxications
are severe, possibly fatal.
May cause:
allergic reactions, epigastric pain, peptic ulcer, haemorrhage;
dizziness, tinnitus (early signs of overdose).
For all cases above, stop aspirin and use paracetamol.
Do not combine with methotrexate, anticoagulants and NSAID.
Monitor combination with insulin (increased hypoglycaemia) and corticosteroids.
Pregnancy: not recommended during the first 5 months; CONTRA-INDICATED from the beginning of
the 6th month (use paracetamol)
Breast-feeding: avoid (use paracetamol)

Remarks

16

In children less than 16 years, preferably use paracetamol.


Take during meals, preferably with a lot of water.
For the treatment of moderate pain, it is recommended to combine aspirin with codeine or
tramadol.
Aspirin may be administered for its antiplatelet effects in secondary prevention of atherothrombosis, at a dose of 75 to 300 mg daily.
Storage: below 25C
Do not use if tablets have a strong smell of vinegar. A slight vinegar smell is always present.

ACICLOVIR
(Zovirax)

Prescription under medical supervision

Antiviral active against herpes simplex virus and varicella zoster virus

Therapeutic action

Treatment of recurrent or extensive oral and oesophageal herpes in immunocompromised


patients
Treatment of herpetic kerato-uveitis
Treatment of genital herpes
Secondary prophylaxis of herpes in patients with frequent and/or severe recurrences
Treatment of severe forms of zoster: necrotic or extensive forms, facial or ophthalmic zoster

Indications

200 mg and 800 mg tablets


Also comes in 40 mg/ml oral suspension.

Presentation

Treatment of recurrent or extensive oral and oesophageal herpes in immunocompromised patients,


treatment of herpetic kerato-uveitis
Child under 2 years: 200 mg 5 times per day for 7 days
Child over 2 years and adult: 400 mg 5 times per day for 7 days

Dosage and duration

Treatment of genital herpes


Child over 2 years and adult: 400 mg 3 times per day for 7 days; in immunocompromised
patients, continue treatment until clinical resolution
Secondary prophylaxis of herpes in patients with frequent and/or severe recurrences
Child under 2 years: 200 mg 2 times per day
Child over 2 years and adult: 400 mg 2 times per day
Treatment of severe forms of zoster
Adult: 800 mg 5 times per day for 7 days

Do not administer to patients with hypersensitivity to aciclovir.


May cause: headache, skin rash, allergic reactions, gastrointestinal disturbances, raised
transaminases, neurologic disorders in patients with renal impairment and elderly
patients; rarely, haematological disorders.
Reduce dosage in patients with renal impairment.
Drink a lot of liquid during treatment.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

For the treatment of herpes simplex, aciclovir should be started as soon as possible (within
96 hours) after the appearance of lesions to reduce severity and duration of infection.
For the treatment of herpes zoster, aciclovir should be start preferably within 72 hours after
the appearance of lesions. Aciclovir administration does not reduce the likelihood of
developing zoster-associated pain but reduces the overall duration of this pain.
Storage: below 25C

Remarks

17

ALBENDAZOLE
(Eskazole, Zentel)

Prescription under medical supervision

Therapeutic action

Anthelminthic

Indications

Ascariasis (Ascaris lumbricoides), enterobiasis (Enterobius vermicularis), hookworm infections


(Ancylostoma duodenale, Necator americanus)
Trichuriasis (Trichuris trichiura), strongyloidiasis (Strongyloides stercoralis)
Trichinellosis (Trichinella spp)

Presentation

400 mg tablet

Dosage and duration

Ascariasis, enterobiasis, hookworm infections


Child over 6 months and adult: 400 mg as a single dose
Child over 6 months but under 10 kg: 200 mg as a single dose
In the event of enterobiasis, a second dose may be given after 2 to 4 weeks.
Trichuriasis, strongyloidiasis
Child over 6 months and adult: 400 mg once daily for 3 days
Child over 6 months but under 10 kg: 200 mg once daily for 3 days

Trichinellosis
Child over 2 years: 10 mg/kg/day in 2 divided doses for 10 to 15 days
Adult: 800 mg/day in 2 divided doses for 10 to 15 days

Contra-indications, adverse effects, precautions

Do not administer to children under 6 months.


Do not administer to patients with ocular cysticercosis.
May cause:
gastrointestinal disturbances, headache, dizziness;
neurological disorders (headache, seizures) in patients with undiagnosed neurocysticercosis.
Pregnancy: avoid during the first trimester
Breast-feeding: no contra-indication

Remarks

Tablets are to be chewed or crushed: follow manufacturer's recommendations.


In the treatment of strongyloidiasis, ivermectin is more effective than albendazole.
Albendazole is also used in the treatment of cutaneous larva migrans (Ancylostoma
braziliense and caninum), larval cestode infections (hydatid disease, certain forms of
neurocysticercosis) and in mass treatment for lymphatic filariasis (check national
recommendations).

Storage:

18

ALUMINIUM HYDROXIDE

1
Antacid

Therapeutic action
Stomach pain associated with gastritis and peptic ulcer

Indications

500 mg tablet
There are numerous preparations of aluminium and/or magnesium hydroxide and different
dosages.

Presentation

Child over 5 years: rarely indicated. When necessary: half a tablet 3 times/day
Adult: 3 to 6 tablets/day after meals or 1 tablet during painful attacks

Dosage

Duration: according to clinical response

May cause: constipation (except when tablets contain magnesium salts or magnesium
hydroxide).
Decreases intestinal absorption of many drugs such as tetracycline, iron salts, isoniazid,
ethambutol, chloroquine, atenolol, digoxin, fluoroquinolones, corticosteroids, indometacin,
ketoconazole, thyroxine, etc. Do not administer simultaneously with these drugs, administer
2 hours apart.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Chew tablets.
Storage: no special temperature requirements

Remarks

19

AMITRIPTYLINE
(Elavil, Laroxyl, Triptyzol)

Prescription under medical supervision

Tricyclic antidepressant with anxiolytic and sedative properties

Therapeutic action

Neuropathic pain, often in combination with carbamazepine


Major depression, especially when a sedative effect is required

Indications

25 mg tablet

Presentation

Adult:
Neuropathic pain: initial dose of 25 mg once daily at bedtime for one week. Increase to
50 mg once daily the following week, then 75 mg once daily at bedtime as of the third
week (max. 150 mg/day).
Depression: the usual dose is 75 to 150 mg once daily (depending on efficacy and
tolerance) at bedtime. The dose is also increased progressively but more rapidly, over
8 to 10 days.
Reduce the dose by half in elderly patients and in patients with hepatic or renal impairment.

Dosage

Neuropathic pain: several months (3 to 6) after pain relief is obtained, then attempt to stop
treatment.
Depression: minimum 6 months. The treatment should be discontinued gradually (dose
tapered over 4 weeks). If signs of relapse occur, increase the dose.

Duration

Do not administer to patients with recent myocardial infarction, arrhythmia, closed-angle


glaucoma, prostate disorders.
Administer with caution and carefully monitor use in patients > 60 years and in patients with
epilepsy, chronic constipation, renal or hepatic impairment, history of bipolar disorders.
May cause:
drowsiness (caution when driving/operating machinery), orthostatic hypotension, sexual
dysfunction;
anticholinergic effects: dry mouth, blurred vision, constipation, tachycardia, disorders of
micturition. These adverse effects are transitory or disappear with dose reduction.
Treatment should be discontinued in the event of severe reactions (mental confusion,
urinary retention, cardiac rhythm disorders);
psychic disorders: exacerbation of anxiety, possibility of a suicide attempt at the beginning
of therapy, manic episode during treatment.
Do not combine with another antidepressant.
Monitor combination with CNS depressants (opioid analgesics, sedatives, H1 antihistamines, etc.), drugs known to have anticholinergic effects (atropine, carbamazepine,
chlorpromazine, promethazine, etc.), drugs which lower the seizure threshold (antispychotics,
mefloquine, tramadol, etc.), lithium and other serotonergics.
Avoid alcohol during treatment.
Pregnancy: re-evaluate whether the treatment is still necessary; if it is continued, decrease the dose
at the end of pregnancy to avoid gastrointestinal and neurological adverse effects in the newborn
infant.
Breast-feeding: monitor the child for excessive somnolence.

Contra-indications, adverse effects, precautions

Sedative effect occurs following initial doses, analgesic effect is delayed for 7 to 10 days. For
depression, it is necessary to wait 3 weeks before assessing therapeutic efficacy. This must
be explained to the patient.
Storage: no special temperature requirements

Remarks

20

AMODIAQUINE = AQ
(Camoquin)
Do not administer the combination artesunateamodiaquine as separate tablets (i.e. artesunate tablets
+ amodiaquine tablets). Use coformulated tablets (e.g.
Coarsucam) or, if not available, co-blisters.

Prescription under medical supervision

Antimalarial

Therapeutic action
Treatment of uncomplicated falciparum malaria, in combination with artesunate
Completion treatment following parenteral therapy for severe falciparum malaria, in
combination with artesunate

Indications

200 mg amodiaquine hydrochloride tablet, containing 153 mg amodiaquine base

Presentation

Child and adult: 10 mg base/kg once daily for 3 days

Dosage and duration


Age

5 to 11 months
1 to 6 years

7 to 13 years

14 years/adult

D1

1/2

153 mg base tablet

tab

1 tab

2 tab

4 tab

D2

1/2

tab

1 tab

2 tab

4 tab

D3

1/2

tab

1 tab

2 tab

4 tab

Do not administer in the event of previous severe adverse reaction to treatment with
amodiaquine (e.g. hypersensitivity reaction, hepatitis, leucopenia, agranulocytosis).
Do not administer to patients taking efavirenz.
May cause: gastrointestinal disturbances, pruritus.
Pregnancy: no contra-indication during the 2nd and 3rd trimester. Safety in the first trimester has not
been definitely established. However, given the risks associated with malaria, the combination
artesunate-amodiaquine may be used during the first trimester if it is the only effective treatment
available.
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Also comes in 260 mg amodiaquine hydrochloride tablet, containing 200 mg amodiaquine


base.
Amodiaquine should not be used for prophylaxis.
Storage: below 25C

Remarks

21

Revised May 2014

AMOXICILLIN

Therapeutic action

Penicillin antibacterial

Prescription under medical supervision

Indications

Acute otitis media, streptococcal tonsillitis, sinusitis, bronchitis, pneumonia


Infection due to Helicobacter pylori (in combination with omeprazole and metronidazole or
tinidazole), leptospirosis
Typhoid fever (if ciprofloxacin is contra-indicated and if the strain is susceptible)
Completion treatment following parenteral therapy with penicillins or cephalosporins

Presentation

250 mg and 500 mg tablets or capsules


250 mg dispersible scored tablet, for paediatric use
125 mg/5 ml powder for oral suspension, to be reconstituted with filtered water

Dosage

Usual dosage (e.g. leptospirosis, tonsillitis, infection due to H. pylori)


Child: 50 mg/kg/day in 2 divided doses
Adult: 2 g/day in 2 divided doses
Age
Weight
125 mg/5 ml susp.
< 3 months
< 6 kg
1 tsp x 2
3 to < 24 months
6 to < 12 kg
2 tsp x 2
2 to < 8 years
12 to < 25 kg
4 tsp x 2
8 years and adult
25 kg

250 mg tablet
tab x 2
1 tab x 2
2 tab x 2
4 tab x 2

500 mg tablet

1 tab x 2
2 tab x 2

Age
Weight
125 mg/5 ml susp.
< 3 months
< 6 kg
1 tsp x 3
3 to < 24 months
6 to < 12 kg
2 tsp x 3
2 to < 8 years
12 to < 25 kg
4 tsp x 3
8 years and adult
25 kg

250 mg tablet
tab x 3
1 tab x 3
2 tab x 3
4 tab x 3

500 mg tablet

1 tab x 3
2 tab x 3

Severe infections (e.g. typhoid) or suspicion of resistant pneumococci (e.g. pneumonia, otitis)
Child: 80 to 100 mg/kg/day in 3 divided doses (max. 3 g)
Adult: 3 g/day in 3 divided doses

Duration

Otitis media: 5 days; tonsillitis: 6 days; leptospirosis: 7 days; pneumonia and sinusitis: 7 to 10 days;
H. pylori infection: 10 to 14 days; typhoid fever: 14 days

Contra-indications, adverse effects, precautions

Do not administer to penicillin-allergic patients or patients with mononucleosis.


Administer with caution to patients allergic to cephalosporins (cross-sensitivity may occur).
May cause: gastrointestinal disturbances, allergic reactions, sometimes severe. In the event
of allergic reaction, stop treatment immediately.
Reduce dosage in patients with severe renal impairment.
Do not combine with methotrexate.
Pregnancy and breast-feeding: no contra-indication

Remarks

Storage: below 25C

For the oral suspension (powder or reconstituted suspension): follow manufacturers instructions.

22

AMOXICILLIN/CLAVULANIC acid = CO-AMOXICLAV


(Augmentin)
Prescription under medical supervision
Combination of two antibacterials. The addition of clavulanic acid to amoxicillin extends its
spectrum of activity to cover beta-lactamase producing Gram-positive and Gram-negative
organisms, including some Gram-negative anaerobes.

Therapeutic action

Animal bites, if antibiotic therapy or antibiotic prophylaxis is clearly indicated


Second line treatment of acute otitis media and acute bacterial sinusitis, when amoxicillin
alone given at high dose failed
Acute uncomplicated cystitis (no systemic signs) in girls > 2 years
Postpartum upper genital tract infection
Severe pneumonia: parenteral to oral switch therapy in patients treated with ceftriaxone +
cloxacillin

Indications

The ratio of amoxicillin and clavulanic acid varies according to the manufacturer:

Presentation

Ratio 8:1
Ratio 7:1
Ratio 4:1

500 mg amoxicillin/62.5 mg clavulanic acid tablet


500 mg amoxicillin/62.5 mg clavulanic acid/5 ml powder for oral
suspension

875 mg amoxicillin/125 mg clavulanic acid tablet


400 mg amoxicillin/57 mg clavulanic acid/5 ml, powder for oral
suspension
500 mg amoxicillin/125 mg clavulanic acid tablet
125 mg amoxicillin/31.25 mg clavulanic acid/5 ml, powder for oral
suspension

Also comes in formultions with a ratio amoxicillin/clavulanic acid of 16:1, 14:1, 6:1, 2:1.

Dosage (expressed in amoxicillin)

Animal bites; second line treatment of acute otitis media and acute sinusitis
Child < 40 kg: 45 to 50 mg/kg/day in 2 divided doses (if using ratio 8:1 or 7:1) or in
3 divided doses (if using ratio 4:1)
Note: the dose of clavulanic acid should not exceed 12.5 mg/kg/day or 375 mg/day.
Child 40 kg and adult: 1500 to 2000 mg/day depending on the formulation available:
Ratio 8:1: 2000 mg/day = 2 tablets of 500/62.5 mg 2 times per day
Ratio 7:1: 1750 mg/day = 1 tablet of 875/125 mg 2 times per day
Ratio 4:1: 1500 mg/day = 1 tablet of 500/125 mg 3 times per day
Note: the dose of clavulanic acid should not exceed 375 mg/day.
Acute uncomplicated cystitis in girls > 2 years
25 mg/kg/day in 2 divided doses (if using ratio 8:1 or 7:1 or 4:1)
Note: the dose of clavulanic acid should not exceed 12.5 mg/kg/day or 375 mg/day.

23

Postpartum upper genital tract infection; parenteral to oral switch therapy in severe pneumonia
Use formulations with a ratio 8:1 or 7:1:
Child < 40 kg: 80 to 100 mg/kg/day in 2 or 3 divided doses
Note: the dose of clavulanic acid should not exceed 12.5 mg/kg/day or 375 mg/day.
Child 40 kg and adult: 2500 to 3000 mg/day in 3 divided doses. Depending on the
formulation available:
Ratio 8:1: 3000 mg/day = 2 tablets of 500/62.5 mg 3 times per day
Ratio 7:1: 2625 mg/day = 1 tablet of 875/125 mg 3 times per day
Note: the dose of clavulanic acid should not exceed 375 mg/day.
Animal bites: 5 to 7 days; otitis media: 5 days; sinusitis: 7 to 10 days; cystitis: 3 days; upper
genital tract infection: 7 days; parenteral to oral switch therapy in severe pneunonia: to complete
a total of 10 to 14 days of treatment.

Duration

Do not administer to penicillin-allergic patients and patients with history of hepatic disorders
during a previous treatment with co-amoxiclav.
Administer with caution to patients allergic to cephalosporins (cross-sensitivity may
occur).
Administer with caution to patients with hepatic impairment; reduce dosage and give
every 12 to 24 hours in patients with severe renal impairment.
May cause: gastrointestinal disturbances (mainly diarrhoea); allergic reactions sometimes
severe (stop treatment immediately); jaundice and cholestatic hepatitis in the event of
prolonged treatment (> 10 to 15 days).
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

High doses of co-amoxiclav (80-100 mg/kg/day or 2.5-3 g/day) cannot be administered


when using formulations of amoxicillin/clavulanic acid in a ratio of 4:1 (the content in
clavulanic acid is too high). The maximum dose (expressed in amoxicillin) that can be given
with these formulations is 50 mg/kg/day, without exceeding 1500 mg/day.
Take with meals.

Storage: below 25C


Powder for oral suspension: between 15C and 25C
Once reconstituted, the oral suspension must be kept refrigerated (between 2C and 8C) and may
be used for up to 7 days.

Remarks

24

ARTEMETHER/LUMEFANTRINE = COARTEMETHER
(Coartem, Riamet)

Prescription under medical supervision

Antimalarial

Therapeutic action
Treatment of uncomplicated falciparum malaria
Completion treatment following parenteral therapy for severe falciparum malaria

Indications

20 mg artemether/120 mg lumefantrine co-formulated tablets, in blister packs, for a complete


treatment for one individual
Blister packs of 6, 12, 18 or 24 tablets, corresponding to 4 different categories of age/weight
Blister-packs of 6 and 12 tablets contain dispersible tablets.

Presentation

The treatment is administered twice daily for 3 days. On D1, the first dose is given at 0 hour
and the second dose at 8-12 hours. Subsequent doses on D2 and D3 are given twice daily
(morning and evening).

Dosage and duration

Age

< 3 years

Weight

D2

D3

5 to 14 kg

1 tab x 2

1 tab x 2

1 tab x 2

25 to 34 kg

3 tab x 2

3 tab x 2

3 tab x 2

3 to 8 years

15 to 24 kg

> 14 years/adult

> 34 kg

9 to 14 years

D1

20/120 mg tablet

2 tab x 2
4 tab x 2

2 tab x 2
4 tab x 2

2 tab x 2
4 tab x 2

Do not combine with azole antifungals (fluconazole, itraconazole, miconazole, etc.), tricyclic
antidepressants, neuroleptics (chlorpromazine, haloperidol, etc.), macrolides, quinolones,
other antimalarials, beta-blockers.
May cause: nausea, headache, dizziness and gastrointestinal disturbances.
If the patient vomits within one hour of administration: repeat the full dose.
Pregnancy: no contra-indication during the 2nd and 3rd trimester. Safety of coartemether in the first
trimester has not been definitely established. However, given the risks associated with malaria, it
may be used during the first trimester if it is the only effective treatment available.
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Take with meals.


Coartemether should not be used for malaria prophylaxis.
Lumefantrine is also called benflumetol.

Storage: below 30C


Leave tablets in blisters until use. Once a tablet is removed from its blister, it must be administered
immediately.

Remarks

25

ARTESUNATE = AS
(Arsumax, Plasmotrim)

Prescription under medical supervision

Oral artesunate must always be administered in combination


with another antimalarial: artesunate-amodiaquine or artesunatemefloquine or artesunate-sulfadoxine/pyrimethamine. These
therapeutic combinations can be coformulated tablets (artesunate
and the 2nd antimalarial combined in the same tablet, in
blister-pack containing a complete course of treatment) or
co-blistered tablets (tablets of artesunate and tablets of the
2nd antimalarial in the same blister-pack containing a complete
course of treatment). Use coformulated tablets when available.
Antimalarial

Therapeutic action
Treatment of uncomplicated falciparum malaria
Completion treatment following parenteral therapy for severe falciparum malaria

Indications

50 mg tablet
Also comes in 100 mg and 200 mg tablets.

Presentation

Child and adult: 4 mg/kg/day once daily for 3 days

Dosage and duration


Age

Weight

50 mg tablet

9 to 17 kg

1 tab

2 to 11 months

4.5 to 8 kg

6 to 13 years

18 to 35 kg

1 to 5 years

14 years/adult

36 kg

1/2

tab

2 tab

4 tab

100 mg tablet

1/2

tab

1 tab
2 tab

200 mg tablet

1/2

tab

1 tab

May cause: gastrointestinal disturbances, headache and dizziness.


Pregnancy: no contra-indication during the 2nd and 3rd trimester. Safety of artesunate during the
first trimester has not been definitely established. However, given the risks associated with malaria,
a drug combination containing artesunate may be used in the first trimester if it is the only effective
treatment available.
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Artesunate should not be used for malaria prophylaxis.

Storage: below 30C

Remarks

26

ARTESUNATE/AMODIAQUINE = AS/AQ
(Coarsucam)

Prescription under medical supervision

Antimalarial

Therapeutic action
Treatment of uncomplicated falciparum malaria
Completion treatment following parenteral therapy for severe falciparum malaria

Indications

Co-formulated tablets of artesunate (AS)/amodiaquine (AQ), in blister packs, for a complete


treatment for one individual
There are 4 different blister packs corresponding to 4 different categories of age/weight:
25 mg AS/67.5 mg AQ base tablet, blister pack of 3 tablets
50 mg AS/135 mg AQ base tablet, blister pack of 3 tablets
100 mg AS/270 mg AQ base tablet, blister pack of 3 tablets
100 mg AS/270 mg AQ base tablet, blister pack of 6 tablets

Presentation

Tablets are to be taken once daily for 3 days.

Dosage and duration


Age

Weight

Tablets

D1

D2

D3

2 to 11 months

4.5 to 8 kg

25 mg AS/67.5 mg AQ

1 tab

1 tab

1 tab

6 to 13 years

18 to 35 kg

100 mg AS/270 mg AQ
blister pack of 3 tab

1 tab

1 tab

1 tab

1 to 5 years

14 years/adult

9 to 17 kg

36 kg

50 mg AS/135 mg AQ

100 mg AS/270 mg AQ
blister pack of 6 tab

1 tab

2 tab

1 tab

2 tab

1 tab

2 tab

Do not administer in the event of previous severe adverse reaction to treatment with
amodiaquine (e.g. hypersensitivity reaction, hepatitis, leucopenia, agranulocytosis).
Do not administer to patients taking efavirenz.
May cause: gastrointestinal disturbances, headache, dizziness, pruritus.
If the patient vomits within half an hour of administration: repeat the full dose.
Pregnancy: no contra-indication during the 2nd and 3rd trimester. Safety in the first trimester has not
been definitely established. However, given the risks associated with malaria, the combination
artesunate/amodiaquine may be used during the first trimester if it is the only effective treatment
available.
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Storage: below 30C

Leave tablets in blisters until use. Once a tablet is removed from its blister, it must be administered
immediately.

Remarks

27

ARTESUNATE + SULFADOXINE/PYRIMETHAMINE = AS + SP
(Artecospe adult, Sulfamon)

Prescription under medical supervision

Antimalarial

Therapeutic action
Treatment of uncomplicated falciparum malaria
Completion treatment following parenteral therapy for severe falciparum malaria

Indications

Artesunate (AS) tablets and sulfadoxine/pyrimethamine (SP) tablets, in blister packs, for a
complete treatment for one individual
There are 4 different blister packs:
Child 2 months to 6 years: blister pack with 3 tab AS 50 mg and 1 tab SP 500/25 mg
Child 7 to 13 years:
blister pack with 6 tab AS 50 mg and 2 tab SP 500/25 mg
Child 14 years and adult: blister pack with 12 tab AS 50 mg and 3 tab SP 500/25 mg
or blister pack with 6 tab AS 100 mg and 3 tab SP 500/25 mg

Presentation

Artesunate is administered once daily for 3 days. Sulfadoxine/pyrimethamine is administered


as a single dose on D1, with the first dose of artesunate.

Dosage and duration


Age

2 to 11 months
1 to 6 years

7 to 13 years

14 years/adult

Blister pack

3 tab AS + 1 tab SP
6 tab AS + 2 tab SP

12 tab AS + 3 tab SP
6 tab AS + 3 tab SP

D1

1/2 tab AS + 1/2 tab

SP

1 tab AS + 1 tab SP
2 tab AS + 2 tab SP
4 tab AS + 3 tab SP
2 tab AS + 3 tab SP

1/2

D2

tab AS

1 tab AS
2 tab AS
4 tab AS
2 tab AS

1/2

D3

tab AS

1 tab AS
2 tab AS
4 tab AS
2 tab AS

Do not administer to patients with allergy to sulfonamides.


May cause: see artesunate and sulfadoxine/pyrimethamine.
Do not use in combination with cotrimoxazole.
Do not give folic acid on the same day SP is administered, or within 15 days thereafter.
Pregnancy: no contra-indication during the 2nd and 3rd trimester. Safety in the first trimester has
not been definitely established. However, given the risks associated with malaria, the combination
artesunate+SP may be used during the first trimester if it is the only effective treatment available.
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Storage: below 30C

Leave tablets in blisters until use. Once a tablet is removed from its blister, it must be administered
immediately.
If half tablets are used, remaining 1/2 tablets may be given to another patient if administered within
24 hours.

Remarks

28

ASCORBIC acid = VITAMIN C


(Laroscorbine, Redoxon, Vitascorbol)

1
Vitamin

Therapeutic action
Treatment and prevention of scurvy (vitamin C deficiency)

Indications

50 mg tablet
Also comes in 250 mg, 500 mg and 1 g tablets.

Presentation

Treatment:
Child: 150 to 200 mg/day in 3 or 4 divided doses
Adult: 500 to 750 mg/day in 3 or 4 divided doses
The treatment is continued until symptoms improve (1 to 2 weeks), then a preventive
treatment is given as long as the situation requires.

Dosage and duration

Prevention:
Child and adult: 25 to 50 mg/day, as long as the situation requires

Ascorbic acid is well tolerated at indicated doses.


May cause: gastrointestinal disturbances and nephrolithiasis for doses > 1 g/day; may
interfere with the measurement of glucose in blood and urine for doses 2 g/day.
Pregnancy: no contra-indication, do not exceed 1 g/day
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Storage: below 30C

Remarks

29

Revised September 2014

ATENOLOL
(Tenormin)

Prescription under medical supervision

Therapeutic action

Cardioselective beta-blocker

Indications

Hypertension
Prophylaxis of angina pectoris, secondary prophylaxis of myocardial infarction
Arrhythmia

Presentation

50 mg tablet

Dosage

Hypertension
Adult: 50 to 100 mg once daily, preferably in the morning
Other indications
Adult: 50 to 100 mg once daily or in 2 divided doses

Duration

According to clinical response. Do not stop treatment abruptly, decrease doses gradually.

Contra-indications, adverse effects, precautions

Do not administer to patients with asthma, chronic obstructive bronchopneumonia, heart


failure, severe hypotension, bradycardia < 50/minute, atrio-ventricular heart blocks,
Raynaud's syndrome.
May cause: bradycardia, hypotension, heart failure, bronchospasm, hypoglycaemia, gastrointestinal disturbances, headache, fatigue.
Administer with caution to patients with diabetes (risk of hypoglycaemia).
Reduce dosage in patients with renal impairment.
In the event of anaphylactic shock, risk of resistance to epinephrine.
Avoid or monitor combination with: mefloquine, digoxin, amiodarone, diltiazem, verapamil
(risk of bradycardia); tricyclic antidepressants, neuroleptics, other anti-hypertensive drugs
(risk of hypotension).
Do not administer simultaneously with antacids (aluminium or magnesium hydroxide,
etc.). Administer 2 hours apart.
Pregnancy: no contra-indication. Labetalol is preferred for the management of hypertension in
pregnancy.
Breast-feeding: avoid

Remarks

Storage: below 25C

30

Revised February 2015

AZITHROMYCIN

Therapeutic action

Macrolide antibacterial

Prescription under medical supervision

Indications

Trachoma, conjunctivitis due to Chlamydia trachomatis


Cervicitis and urethritis due to Chlamydia trachomatis (in combination with a treatment for
gonorrhoea), donovanosis, chancroid, early syphilis
Cholera (if the strain is susceptible), yaws
Pertussis, pneumonia due to Mycoplasma pneumoniae and Chlamydophila pneumoniae
Streptococcal tonsillitis, acute otitis media, in penicillin-allergic patients only

Presentation

250 mg and 500 mg capsules or tablets


200 mg/5 ml powder for oral suspension, to be reconstituted with filtered water

Dosage and duration

Trachoma, cholera, cervicitis and urethritis due to C. trachomatis, chancroid, early syphilis
Child: 20 mg/kg as a single dose (max. 1 g)
Adult: 1 g as a single dose (2 g as a single dose in early syphilis)
Yaws
Child and adult: 30 mg/kg as a single dose (max. 2 g)
Conjunctivitis due to C. trachomatis
Child: 20 mg/kg once daily for 3 days (max. 1 g/day)
Adult: 1 g once daily for 3 days
Donovanosis (granuloma inguinale)
Adult: 1 g on D1 then 500 mg/day until healing of lesions
Pertussis, pneumonia due to M. pneumoniae and C. pneumoniae
Child: 10 mg/kg once daily for 5 days (max. 500 mg/day)
Adult: 500 mg on D1 then 250 mg from D2 to D5
Streptococcal tonsillitis, only in penicillin-allergic patients
Child: 20 mg/kg once daily for 3 days (max. 500 mg/day)
Adult: 500 mg once daily for 3 days
Acute otitis media, only in penicillin-allergic patients
Child: 10 mg/kg once daily for 3 days (max. 500 mg/day)

Contra-indications, adverse effects, precautions

Do not administer to patients with allergy to azithromycin or another macrolide, and to


patients with severe hepatic impairment.
May cause: gastrointestinal disturbances, heart rhythm disorders (QT prolongation), allergic
reactions sometimes severe. In the event of allergic reaction, stop treatment immediately.
Do not administer simultaneously with antacids (aluminium or magnesium hydroxide,
etc.). Administer 2 hours apart.
Avoid combination with drugs that prolong the QT interval (amiodarone, chloroquine,
co-artemether, fluconazole, haloperidol, mefloquine, moxifloxacin, ondansetron, pentamidine,
quinine, etc.).
Administer with caution and monitor use in patients taking digoxin (increased digoxin
plasma levels).
Pregnancy and breast-feeding: no contra-indication

Remarks

Also comes in 250 mg or 500 mg capsules, to be taken one hour before or 2 hours after a meal.
Storage: below 25C

For the oral suspension (powder or reconstituted suspension): follow manufacturers instructions.

31

BECLOMETASONE aerosol
(Beclazone, Becotide)
Therapeutic action

Prescription under medical supervision

Anti-inflammatory drug (corticosteroid)

Indications

Long term treatment of persistent asthma

Presentation and route of administration

Pressurized inhalation solution of beclomatesone dipropionate, 50 micrograms and


100 micrograms/inhalation

Dosage and administration

The dosage varies from one person to another. The initial dose depends on the severity of
symptoms. It may be increased or reduced over time. Always try to administer the lowest
effective dose. For information:
Mild to moderate persistent asthma
Child: 100 to 400 micrograms/day in 2 or 4 divided doses
Adult: 500 to 1000 micrograms/day in 2 or 4 divided doses
Severe persistent asthma
Child: up to 800 micrograms/day in 2 or 4 divided doses
Adult: up to 1500 micrograms/day in 2 or 4 divided doses

Shake the inhaler. Breathe out as completely as possible. Place the lips tightly around the
mouthpiece. Inhale deeply while activating the inhaler. Hold breath 10 seconds before
exhaling. Verify that the inhalation technique is correct.
Co-ordination between the hand and inhalation is very difficult in certain patients (children
under 6 years, elderly patients, etc.). Use a spacer to facilitate administration and improve the
efficacy of treatment.

Duration: according to clinical response

Contra-indications, adverse effects, precautions

Do not administer to patients with untreated active tuberculosis.


May cause: throat irritation, hoarseness at the beginning of treatment, oro-pharyngeal
candidiasis.
In the event of cough and/or bronchospasm following inhalation of beclometasone:
administer salbutamol if necessary, stop inhalation of beclometasone and replace with an
oral corticoid.
In the event of bronchial infection, administer appropriate antibiotic treatment in order to
optimise the diffusion of beclometasone in the respiratory tract.
If the maximum dosage becomes insufficient, re-evaluate the severity of asthma and
combine with a short oral anti-inflammatory treatment.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Remarks

32

Beclometasone is not a bronchodilator. For asthma attack, use inhaled salbutamol.


Relief of symptoms may require several days or weeks of continuous therapy.
Clean the mouthpiece before and after each use.
Do not pierce or incinerate used aerosol containers. Empty all residual gas, then bury.
Storage: below 25C

BIPERIDEN
(Akineton)

Prescription under medical supervision

Anticholinergic antiparkinson drug

Therapeutic action

Extrapyramidal syndrome induced by antipsychotics

Indications

2 mg tablet

Presentation

Adult: initial dose of 2 mg/day in 2 divided doses, increased gradually if necessary up to


4 to 6 mg/day in 2 to 3 divided doses (max. 8 mg/day)
Administer in the lowest effective dose in elderly patients.

Dosage

Duration: as long as the antipsychotic treatment lasts.

Do not administer to patients with closed-angle glaucoma, decompensated heart disease,


prostate disorders, gastrointestinal obstruction or atony.
Administer with caution and carefully monitor use in patients > 60 years (risk of mental
confusion, hallucinations).
May cause: anticholinergic effects (dry mouth, blurred vision, urinary retention, constipation,
tachycardia), drowsiness (inform the patient that it may affect the capacity to drive or operate
machinery). In these events, reduce the dose.
Avoid or monitor combination with other drugs known to have anticholinergic effects
(amitriptyline, atropine, carbamazepine, clomipramine, promethazine, etc.).
Pregnancy: re-evaluate whether the antipsychotic treatment is still necessary; if treatment is
continued, administer biperiden in the lowest effective dose and observe the newborn infant if the
mother was under treatment in the 3rd trimester (risk of anticholinergic effect, e.g. tremors,
abdominal distension).
Breast-feeding: no contra-indication. Administer in the lowest effective dose and observe the child
(risk of anticholinergic effects, e.g. tachycardia, constipation, thickening of bronchial secretions).

Contra-indications, adverse effects, precautions

Biperiden is also used in Parkinsons disease:


as monotherapy early in the course of the disease;
in combination with levodopa in the most advanced stages.
Also comes in 4 mg extended-release tablet, administered once daily in the morning.
Storage:

Remarks

33

BISACODYL
(Dulcolax)

Stimulant laxative

Therapeutic action

Prevention of constipation in patients taking opioid analgesics (codeine, morphine, etc.)


Short-term, symptomatic treatment of constipation

Indications

5 mg enteric-coated tablet

Presentation

Child over 3 years: 5 to 10 mg once daily


Adult: 10 to 15 mg once daily

Dosage

Prevention of constipation in patients taking opioids: start bisacodyl when analgesic treatment
continues more than 48 hours. Tablets must be taken daily, at night (bisacodyl is effective
6 to 12 hours after administration), until the end of the opioid treatment. Regular follow up
(frequency/consistency of stools) is essential in order to adjust dosage correctly.
Treatment of constipation: until the patient passes stools, maximum 7 days.

Duration

Do not administer to patients with Crohn's disease, ulcerative colitis, intestinal obstruction,
undiagnosed abdominal pain and dehydration.
May cause: diarrhoea, abdominal cramps, hypokalaemia.
In the event of diarrhoea: exclude a faecal impaction or intestinal obstruction, stop
treatment for 24 hours and then start again with a half dose.
In the event of abdominal cramps: reduce or divide the daily dose. Stop treatment if pain
continues.
Do not combine with drugs that induce torsades de pointe (halofantrine, erythromycin IV,
pentamidine, etc.).
Closely monitor patients taking drugs that induce hypokalaemia (furosemide, amphotericin B,
corticosteroids, etc.) or cardiac glycosides.
Pregnancy and breast-feeding: avoid; for routine prevention of constipation due to opioids, use
lactulose.

Contra-indications, adverse effects, precautions

To prevent constipation in patients taking opioids, use lactulose if the patients stools are
solid; use bisacodyl if the patients stools are soft.
In children from 6 months to 3 years, do not use the oral route. Use only 5 mg paediatric
suppositories (one suppository/day).
Swallow tablets whole; do not crush or chew.
Bisacodyl is equivalent to senna, the representative example of laxative stimulants in the
WHO list of essential medicines.
The treatment must be accompanied by dietary measures (plenty of fluids and fibre).
Storage: below 30C

Remarks

34

CABERGOLINE
Prescription under medical supervision
Therapeutic action

Long-lasting lactation inhibitor

Indications

Inhibition of lactation or suppression of established lactation in case of intrauterine foetal


death or neonatal death

Presentation

0.5 mg scored tablet

Dosage and duration

Lactation inhibition
1 mg as a single dose on the first day post-partum
Lactation suppression
0.25 mg every 12 hours for 2 days

Contra-indications, adverse effects, precautions

Do not administer to patients with postpartum hypertension or psychosis, preeclampsia,


valvulopathy, and history of pulmonary, retroperitoneal or pericardial fibrosis.
May cause: hypotension, valvulopathy, dizziness, headache, nausea, drowsiness, hallucinations.
Do not combine with chlorpromazine, haloperidol, metoclopramide, promethazine (effect
of cabergoline antagonised), methylergometrine (risk of vasoconstriction and hypertensive
crisis), and macrolides (effect of cabergoline increased).
Pregnancy: CONTRA-INDICATED

Remarks

The use of cabergoline is not recommended to inhibit lactation in women who chose to not
breastfeed: it is not justified to expose women to the adverse effects of cabergoline, lactation
will stop spontaneously.
Cabergoline is not included in the WHO list of essential medicines.
Cabergoline is a dopamine agonist also used in the treatment of Parkinsons disease.

Storage: below 25C

35

CALCIUM FOLINATE = FOLINIC acid


(Refolinon)

Prescription under medical supervision

Antidote to folate antagonists

Therapeutic action

Prevention of haemotological toxicity of pyrimethamine when pyrimethamine is used as


prophylaxis for, or in the treatment of toxoplasmosis or isosporiasis in immunodeficient
patients

Indications

15 mg tablet
Also comes in 5 mg and 25 mg capsules.

Presentation

When pyrimethamine is used as primary or secondary prophylaxis for toxoplasmosis


Adult: 25 to 30 mg once weekly

Dosage

During treatment of toxoplasmosis


Adult: 10 to 25 mg once daily
During treatment of isosporiasis
Adult: 5 to 15 mg once daily

For the duration of the pyrimethamine treatment

Duration

Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Folic acid cannot be used as an alternative to folinic acid for the treatment of toxoplasmosis:
folic acid reduces the antiprotozoal activity of pyrimethamine.
Calcium folinate is also called calcium leucovorin.
Storage: below 30C

Remarks

35

CARBAMAZEPINE
(Tegretal, Tegretol)

Antiepileptic

Prescription under medical supervision

Therapeutic action
Epilepsy (except absence seizures)
Neuropathic pain (alone or combined with amitriptyline)

Indications

100 mg and 200 mg tablets


Also comes in 100 mg/5 ml oral solution.

Presentation

Epilepsy
Child: initially 5 mg/kg once daily or in 2 divided doses, then increase every 2 weeks up
to 10 to 20 mg/kg/day in 2 to 4 divided doses
Adult: initially 100 to 200 mg once daily or in 2 divided doses, then increase by 100 to
200 mg increments every 2 weeks up to 800 to 1200 mg/day in 2 to 4 divided doses
Neuropathic pain
Adult: initially 200 mg once daily at night for one week, then 400 mg/day in 2 divided
doses (morning and night) for one week, then 600 mg/day in 3 divided doses

Dosage

Epilepsy: lifetime treatment. Do not stop treatment abruptly, even if changing treatment to
another antiepileptic.
Neuropathic pain: continue several months after pain relief is obtained, then attempt to stop
treatment.

Duration

Do not administer to patients with atrioventricular block, history of bone marrow depression.
Administer with caution to patients with glaucoma, urinary retention, hepatic or renal
impairment, heart failure or blood disorders and to elderly patients.
May cause:
headache, dizziness, gastrointestinal and visual disturbances, rash, leucopenia, confusion
and agitation in elderly patients, drowsiness (use with caution when driving or operating
machinery),
exceptionally: Lyell's and Stevens-Johnson syndromes, agranulocytosis, anaemia, bone
marrow depression, pancreatitis, hepatitis, cardiac conduction defect. If so, stop treatment.
Do not drink alcohol during treatment.
Do not combine with: erythromycin, isoniazid, valproic acid (increased carbamazepine
plasma concentrations), oestroprogestogens (reduced contraceptive efficacy), saquinavir
(reduced efficacy of saquinavir).
Monitor combination with: oral anticoagulants, corticosteroids, antidepressants, haloperidol,
protease inhibitors, aminophylline, rifampicine, itraconazole, etc.
Pregnancy:
Epilepsy: do not start treatment during the first trimester, except if vital and there is no alternative
(risk of neural tube defect). However, if treatment has been started before a pregnancy, do not stop
treatment. The administration of folic acid before conception and during the first trimester seems
to reduce the risk of neural tube defect.
Due to the risk of haemorrhagic disease of the newborn, administer vitamin K to the mother and
the newborn infant.
Neuropathic pain: not recommended
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Storage:

Remarks
36

CEFALEXIN
Prescription under medical supervision

Therapeutic action

First-generation cephalosporin antibacterial

Indications

Skin infections due to staphylococci and/or streptococci: impetigo, furuncle, erysipelas and
superficial cellulitis

Presentation

250 mg capsule
125 mg/5 ml powder for oral suspension, to be reconstituted with filtered water

Dosage

Neonate under 7 days: 50 mg/kg/day in 2 divided doses


Neonate 7 to 28 days: 75 mg/kg/day in 3 divided doses
The exact dose should be calculated according to the newborns weight.
Child 1 month to 12 years: 25 to 50 mg/kg/day in 2 divided doses
Child over 12 years and adult: 2 g/day in 2 divided doses
Age

1 to < 5 months

5 months to < 3 years


3 to < 6 years

6 to < 12 years

12 years and adult

Duration

Weight

125 mg/5 ml oral susp.

250 mg capsule

7 to < 15 kg

11/2 tsp x 2

20 to < 40 kg

4 to < 7 kg

15 to < 20 kg
40 kg

1 tsp x 2
2 tsp x 2

2 cap x 2
4 cap x 2

Impetigo, furuncle: 7 days; erysipelas, cellulitis: 7 to 10 days

Contra-indications, adverse effects, precautions

Do not administer to patients with allergy to cephalosporin.


Administer with caution to patients with allergy to penicillin (cross-sensitivity may occur)
and severe renal impairment (reduce the dose).
May cause: gastrointestinal disturbances (particularly diarrhoea), allergic reactions (skin
eruption, fever, pruritus).
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Remarks

Take preferably between meals.


Also comes in 250 mg/5 ml powder for oral suspension.
Storage: below 25C

For the oral suspension (powder or reconstituted suspension): follow manufacturers instructions.

38

Revised October 2014

CEFIXIME
Prescription under medical supervision

Therapeutic action

Third-generation cephalosporin antibacterial

Indications

Typhoid fever in children


Acute cystitis in girls over 2 years, pregnant women and lactating women
Acute pyelonephritis in adults
Cervicitis and urethritis due to Neisseria gonorrhoeae (in combination with a treatment for
chlamydia)

Presentation

200 mg tablet
100 mg/5 ml powder for oral suspension, to be reconstituted with filtered water

Dosage

Typhoid fever in children


Child over 3 months: 20 mg/kg/day in 2 divided doses
Acute cystitis in girls over 2 years
8 mg/kg once daily

Acute cystitis in pregnant and lactating women, acute pyelonephritis in adult


400 mg/day in 2 divided doses
Cervicitis and urethritis due to Neisseria gonorrhoeae
Child: 8 mg/kg as a single dose
Adult: 400 mg as a single dose

Duration

Typhoid fever: 7 days; acute cystitis: 3 days for girls and 5 days for adults; acute pyelonephritis:
10 to 14 days

Contra-indications, adverse effects, precautions

Do not administer to patients with allergy to cephalosporins.


Administer with caution to penicillin-allergic patients (cross-sensitivity may occur) and in
patients with severe renal impairment (reduce dosage).
May cause: gastrointestinal disturbances (especially diarrhoea), headache, dizziness,
allergic reactions (rash, pruritus, fever). In the event of allergic reaction, stop treatment
immediately.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Remarks

Also comes in 400 mg capsules.

Storage: below 25C


For the oral suspension (powder or reconstituted suspension): follow manufacturers instructions.

37

Activated CHARCOAL

Therapeutic action
Adsorbent

Indications

Poisoning by drugs, in particular: paracetamol, aspirin, ibuprofen, chloroquine, quinine,


dapsone, phenobarbital, carbamazepine, digoxin
Poisoning by other toxic substances: certain plants (datura, lantana, etc.), certain domestic,
industrial or agricultural chemicals

Presentation

Granules for oral suspension, in 50 g bottle, to be reconstituted with 250 ml of water

Dosage and duration

The dose of charcoal has to be administered as soon as possible (preferably within one hour
after ingestion of the toxic compound) and swallowed within a limited period, e.g., in 15 to
20 minutes:
Child under 1 year: 1 g/kg
Child from 1 to 12 years: 25 g
Child over 12 years and adult: 50 g
If the dose of charcoal is not entirely swallowed or the toxic substance was ingested in large
quantities or over 2 hours beforehand: follow the treatment for 24 hours after poisoning, by
administering half or a quarter of the initial dose of charcoal every 4 or 6 hours, depending
on the tolerance and cooperation of the patient.

Contra-indications, adverse effects, precautions

Do not administer in case of poisoning by caustic or foaming products, or hydrocarbons:


risk of aggravation of lesions during vomiting (caustic products), aspiration pneumonia
(foaming products, hydrocarbons), and airway obstruction due to foaming when vomiting
(foaming products).
The charcoal is ineffective in poisoning by: alcohols (ethanol, glycol ethylene, methanol,
isopropyl alcohol, etc.), organophosphorus and carbamate insecticides, metals (lithium,
iron salts, etc.).
May cause: black colouring of stools (normal), constipation; vomiting in the event of rapid
administration of large quantities.
Do not administer charcoal simultaneously with other drugs by oral route. Administer
2 hours apart.
Pregnancy and breast-feeding: no contra-indication

Remarks

To facilitate the administration of charcoal and avoid vomiting in children, mask the taste
(mix with fruit juice, syrup) and administer the suspension slowly in small quantities.
If there is a specific antidote to the drug ingested, use it in complement.
Storage: below 25C

38

Revised October 2014

CHLORAMPHENICOL

The use of chloramphenicol should be restricted to


severe infections when other less toxic antibacterials
are not effective or contra-indicated.

Prescription under medical supervision

Therapeutic action

Phenicol antibacterial

Indications

Alternative to first-line treatments of bubonic plague


Alternative to first-line treatments of typhoid fever
Completion treatment following parenteral therapy with chloramphenicol

Presentation

250 mg capsule

Dosage

Child from 1 year to less than 13 years: 50 mg/kg/day in 3 to 4 divided doses; 100 mg/kg/day
in severe infection (max. 3 g/day)
Child 13 years and adult: 3 to 4 g/day in 3 to 4 divided doses

Duration

Age
1 to < 4 years
4 to < 9 years
9 to < 13 years
13 years and adult

Weight
10 to < 17 kg
17 to < 30 kg
30 to < 45 kg
45 kg

Plague: 10 days; typhoid fever: 10 to 14 days

250 mg capsule
1 caps x 3
2 caps x 3
3 caps x 3
4 caps x 3

Contra-indications, adverse effects, precautions

Do not administer to children under 1 year.


Do not administer to patients with:
history of allergic reaction or bone marrow depression during a previous treatment with
chloramphenicol;
G6PD deficiency.
May cause:
dose-related haematological toxicity (bone marrow depression, anaemia, leucopenia,
thrombocytopenia), allergic reactions. In these events, stop treatment immediately.
gastrointestinal disturbances, peripheral and optic neuropathies.
Reduce dosage in patients with hepatic or renal impairment.
Avoid or monitor combination with potentially haematotoxic drugs (carbamazepine,
cotrimoxazole, flucytocine, pyrimethamine, zidovudine, etc.).
Pregnancy: CONTRA-INDICATED, except if vital, if there is no therapeutic alternative. If used during
the 3rd trimester, risk of grey syndrome in the newborn infant (vomiting, hypothermia, blue-grey
skin colour and cardiovascular depression).
Breast-feeding: CONTRA-INDICATED

Remarks

Oral treatment is more effective than parenteral treatment: blood and tissue concentrations
are higher when chloramphenicol is given orally.
Capsules can be opened and their content mixed into a spoon with food.
Also comes in 150 mg/5 ml powder for oral suspension.
Storage: below 25C

41

CHLOROQUINE sulfate or phosphate


(Nivaquine)

Given that resistance of P. falciparum to chloroquine is widespread, this drug must not be used for the treatment of falciparum malaria in Africa, South America, Asia and Oceania.

Therapeutic action
Antimalarial

Indications

Treatment of malaria due to P. vivax, P. ovale and P. malariae


Treatment of uncomplicated falciparum malaria, only in areas where P. falciparum is still
sensitive to chloroquine (Central America, Haiti and Dominican Republic)
Prophylaxis of falciparum malaria for non-immune individuals, only in areas where resistance to chloroquine is moderate and always in combination with proguanil

Presentation

100 mg and 150 mg chloroquine base tablets


50 mg chloroquine base/5 ml syrup
The dose written on the labels is sometimes in chloroquine salt and sometimes in chloroquine base which leads to frequent confusion. The WHO recommends prescriptions and labels
in chloroquine base.
100 mg base = approx. 130 mg sulfate = approx. 160 mg phosphate or diphosphate
150 mg base = approx. 200 mg sulfate = approx. 250 mg phosphate or diphosphate

Dosage and duration

Treatment of malaria
Child and adult:
Day 1 and Day 2: 10 mg base/kg once daily
Day 3:
5 mg base/kg

AGE

WEIGHT

100 mg base tablet


Day 1 and Day 2

2
months
4
kg

1/2

Day 3

1/4

Day 3

1/8

150 mg base tablet


Day 1 and Day 2

1/4

tab

1
year
8
kg

5
years

1 tab

tab

1/2

tab

1/4

tab

1/2

tab
tab
tab

15
kg

15
years

2 1/2 tab
1 tab

1 1/2 tab
3/4

tab

35
kg

ADULT

6 tab

3 tab

4 tab

2 tab

39

Prophylaxis of falciparum malaria in areas where resistance to chloroquine is moderate


Child: 1.7 mg chloroquine base/kg once daily (always combined with proguanil)
Adult: 100 mg chloroquine base once daily (always combined with proguanil)
Travellers should start prophylaxis 24 hours before departure, continue throughout the stay
and for at least 4 weeks after return.
In areas where resistance to chloroquine is high, chloroquine must be replaced by another
effective antimalarial suitable for prophylactic use.

Contra-indications, adverse effects, precautions

Do not administer to patients with retinopathy.


May cause: gastrointestinal disturbances, headache, transitory pruritus (lasting 72 hours),
allergic reactions (urticaria, angioedema), visual disturbances.
If the patient vomits within one hour after administration:
during the first 30 minutes: repeat the full dose;
after 30 minutes: give half the dose.
There is a narrow margin between the therapeutic and toxic dose. Doses of 20 mg base/kg
in children and 2 g base in adults are considered toxic.
Do not combine with: coartemether, quinine, mefloquine, halofantrine.
Do not administer simultaneously with antacids (aluminium hydroxide, etc.): administer
2 hours apart.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Remarks

Chloroquine alone (without proguanil) is used as a prophylactic drug in certain areas


where only P. vivax is present.
Resistance of P. vivax to chloroquine exists in Papua New Guinea, Indonesia and Myanmar.
Storage: below 30C

40

CHLORPHENAMINE = CHLORPHENIRAMINE
(Piriton)

1
Sedating antihistamine

Therapeutic action

Symptomatic treatment of minor allergic reactions (contact dermatitis, seasonal allergy,


allergy to drugs, food, etc.)

Indications

4 mg tablet
Also comes in 2 mg/5 ml oral solution.

Presentation

Child from 1 to 2 years: 1 mg 2 times daily


Child from 2 to 6 years: 1 mg 4 to 6 times daily (max. 6 mg/day)
Child from 6 to 12 years: 2 mg 4 to 6 times daily (max. 12 mg/day)
Child over 12 years and adult: 4 mg 4 to 6 times daily (max. 24 mg/day)

Dosage

AGE

WEIGHT

4 mg tablet

1
year

Do not
administer

10
kg

2
years

1/4

tab x 2

13
kg

1/4

6
years

tab x 4

21
kg

1/2

12
years

tab x 4

37
kg

ADULT
1 tab x 4

Duration: according to clinical response; as short as possible.

Administer with caution and monitor use in patients with prostate disorders or closedangle glaucoma, patients > 60 years and children (risk of agitation, excitability).
May cause: drowsiness (caution when driving/operating machinery), anticholinergic
effects (dry mouth, blurred vision, constipation, tachycardia, disorders of micturition),
headache, tremor, allergic reactions.
Monitor combination with CNS depressants (opioid analgesics, antipsychotics, sedatives,
antidepressants, etc.)
Avoid alcohol during treatment.
Pregnancy: no contra-indication; no prolonged treatment.
Breast-feeding: no contra-indication; monitor the child for excessive somnolence.

Contra-indications, adverse effects, precautions

Chlorphenamine is less sedating than promethazine.


Dexchlorpheniramine (Polaramine) has the same indications:
child 1 to 2 years: 0.25 mg 2 to 3 times daily
child 2 to 6 years: 0.5 mg 2 to 3 times daily
child 6 to 12 years: 1 mg 3 to 4 times daily
child over 12 years and adult: 2 mg 3 to 4 times daily
Storage: no special temperature requirements

Remarks

41

CHLORPROMAZINE
(Largactil)
Sedative antipsychotic (neuroleptic)

Therapeutic action

Prescription under medical supervision

Acute or chronic psychosis


Severe anxiety not controlled by benzodiazepines

Indications

25 mg tablet
Also comes in 100 mg tablets.

Presentation

Acute or chronic psychosis


Adult: initial dose of 75 mg/day in 3 divided doses; if necessary, the dose may be gradually
increased up to 300 mg/day in 3 divided doses (max. 600 mg/day). Once the patient is
stable, the maintenance dose is administered once daily in the evening.
Severe anxiety not controlled by benzodiazepines
Adult: 75 to 150 mg/day in 3 divided doses
Whatever the indication, reduce the dose by half in elderly patients.
Use the lowest effective dose, especially in the event of prolonged treatment.

Dosage

Acute psychosis: minimum 3 months; chronic psychosis: minimum one year. The treatment
should be discontinued gradually (over 4 weeks). If signs of relapse occur, increase the dose.
Severe anxiety: maximum 4 weeks.

Duration

Do not administer to patients with closed-angle glaucoma, prostate disorders; to elderly


patients with dementia (e.g. Alzheimer's disease).
Administer with caution and carefully monitor use in patients > 60 years; patients with epilepsy,
chronic constipation, renal or hepatic impairment, Parkinson's disease, myasthenia gravis.
May cause:
drowsiness (caution when driving/operating machinery), orthostatic hypotension, sexual
dysfunction;
anticholinergic effects (dry mouth, blurred vision, urinary retention, constipation, tachycardia);
extrapyramidal syndrome, early or tardive dyskinesia, photosensitivity (patients must
protect themselves from sunlight), jaundice; neuroleptic malignant syndrome (unexplained hyperthermia with neuromuscular disorders), rare but requiring immediate
treatment discontinuation.
In the event of extrapyramidal symptoms, combine with biperiden.
Avoid or monitor combination with: drugs which lower the seizure threshold (mefloquine,
chloroquine, tramadol, tricyclic or SSRI antidepressants); CNS depressants (opioid analgesics,
sedatives, H1 antihistamines, etc.); drugs known to have anticholinergic effects (amitriptyline,
atropine, carbamazepine, clomipramine, promethazine, etc.); antidiabetics, lithium.
Avoid alcohol during treatment.
Chlorpromazine is irritating to the skin/mucous membranes: do not crush tablets.
Pregnancy: re-evaluate whether the treatment is still necessary; if it is continued, monitor the
newborn infant for extrapyramidal and/or anticholinergic effects (tremor, abdominal distension,
hyperexcitability, etc.) if the mother was under high dose treatment in the 3rd trimester.
Breast-feeding: avoid

Contra-indications, adverse effects, precautions

In the event of agitation or aggressiveness in patients under other antipsychotic treatment


(e.g. risperidone or haloperidol), chlorpromazine may be administered at the dose of 75 to
150 mg/day in 3 divided doses for a few days.
Chlorpromazine produces less extrapyramidal symptoms than haloperidol but orthostatic
hypotension and anticholinergic effects are more frequent.
Storage: no special temperature requirements

Remarks

42

CIMETIDINE
(Tagamet)

Prescription under medical supervision

Antiulcer agent (histamine H2-receptor antagonist)

Therapeutic action

Prophylaxis of acid pulmonary aspiration syndrome in anaesthesia:


in patients with a full stomach (emergency caesarean section, etc.)
when a difficult intubation is expected

Indications

200 mg effervescent tablet


Also comes 800 mg effervescent tablet.

Presentation

Adult: 200 to 400 mg as a single dose if possible one hour before anaesthetic induction

Dosage and duration

May cause: diarrhoea, headache, dizziness, skin rash, fever.


Do not administer with an antacid (aluminium hydroxide, etc.).

Contra-indications, adverse effects, precautions

Effervescent cimetidine can be replaced by effervescent ranitidine (Zantac), another H2receptor antagonist, as a single dose of 150 mg.
The onset of acid inhibition with cimetidine non-effervescent tablets (200 mg, 400 mg and
800 mg film coated tablets) or ranitidine non-effervescent tablets (150 mg and 300 mg film
coated tablets) occurs 30 minutes after administration. The effervescent tablets containing
sodium citrate have a more rapid onset of action, and can thus be used for emergency surgery.
Omeprazole (Mopral), another antiulcer agent (proton pump inhibitor), is not compatible
with emergency situations as it must be administered at least 4 hours before surgery.
Cimetidine in film coated tablets is also used in the treatment of gastro-oesophageal reflux
and peptic ulcer. Use by preference ranitidine (Azantac) or omeprazole (Mopral) for
these indications.

Storage: below 30C

Remarks

43

Revised March 2015

CIPROFLOXACIN

Therapeutic action

Fluoroquinolone antibacterial

Prescription under medical supervision

Indications

Shigellosis, typhoid fever, cutaneous anthrax


Uncomplicated acute cystitis in non-pregnant women or in the event of previous treatment
failure, acute prostatitis, uncomplicated acute pyelonephritis, chancroid

Presentation

250 mg and 500 mg tablets


250 mg/5 ml granules and solvent for oral suspension

Dosage

Shigellosis, typhoid fever, cutaneous anthrax


Child over 1 month: 30 mg/kg/day in 2 divided doses (max. 1 g/day)
Adult: 1 g/day in 2 divided doses
Age
1 to < 3 months
3 to < 7 months
7 months to < 2 years
2 to < 3 years
3 to < 8 years
8 to < 11 years
11 years and adult

Weight
4 to < 6 kg
6 to < 8 kg
8 to < 12 kg
12 to < 15 kg
15 to < 26 kg
26 to < 36 kg
36 kg

250 mg/5 ml susp. 250 mg tablet


1.5 ml x 2
2 ml x 2
2.5 ml x 2
4 ml x 2
5 ml x 2
1 tab x 2
8 ml x 2
2 tab x 2

500 mg tablet
1 tab x 2

Uncomplicated acute cystitis in non-pregnant women


Adult: 500 mg/day in 2 divided doses
Acute cystitis (in the event of recurrence or treatment failure), acute prostatitis, chancroid
Adult: 1 g/day in 2 divided doses
Uncomplicated acute pyelonephritis
Adult: 1 to 1.5 g/day in 2 to 3 divided doses

Duration

Shigellosis, uncomplicated cystitis, chancroid: 3 days; cystitis (in the event of recurrence or treatment
failure): 5 days; typhoid fever: 5 to 7 days; pyelonephritis: 7 days; cutaneous anthrax: 7 to 10 days;
prostatitis: 28 days

Contre-indications, effets indsirables, prcautions

Do not administer to patients with history of allergy or tendinitis due to fluoroquinolones.


Administer with caution to epileptic patients (risk of seizures).
Reduce the dose by half in patients with renal impairment.
May cause: gastrointestinal disturbances, neurological disorders (headache, dizziness,
confusion, hallucinations, seizures), allergic reaction, peripheral neuropathy, photosensitivity
(protect skin from sun exposure), arthralgia, myalgia, tendon damage (especially Achilles
tendinitis), QT interval prolongation, hypo/hyperglycaemia, haemolytic anaemia in
patients with G6PD deficiency. In the event of allergic reaction, severe neurological disorders, peripheral neuropathy or tendinitis, stop treatment immediately.
Avoid combination with drugs that prolong the QT interval (amiodarone, chloroquine, coartemether, fluconazole, haloperidol, mefloquine, ondansetron, pentamidine, quinine, etc.)
Monitor patients taking glibenclamide (risk of hypoglycaemia).
Do not administer simultaneously with antacids (aluminium or magnesium hydroxide, etc.),
iron salts, calcium. Administer 2 hours apart.
Drink a lot of liquid during treatment (risk of crystalluria).
Pregnancy: reserved for severe infections, when there is no therapeutic alternative.
Breast-feeding: no contra-indication

Remarks

Storage: below 25C

45

CLINDAMYCIN
(Dalacin)

Prescription under medical supervision

Lincosamide antibacterial

Therapeutic action

Second-line treatment of pneumocystosis, in combination with primaquine


Second-line treatment and secondary prophylaxis of cerebral toxoplasmosis, in combination
with pyrimethamine

Indications

150 mg capsule
Also comes in 75 mg and 300 mg capsules.

Presentation

Treatment of pneumocystosis
Adult: 1800 mg/day in 3 divided doses for 21 days

Dosage and duration

Treatment of toxoplasmosis
Adult: 2400 mg/day in 4 divided doses for 6 weeks

Secondary prophylaxis of toxoplasmosis


Adult: 1800 mg/day in 3 divided doses, as long as required
Do not administer to patients with allergy to lincosamides or history of pseudomembranous colitis.
May cause: diarrhoea (including severe: pseudomembranous colitis), nausea, rash, jaundice,
and allergic reactions sometimes severe.
In the event of allergic reactions, stop treatment immediately. If pseudomembranous colitis
develops (mucus and false membranes), stop clindamycin and treat for C. difficile disease
(oral metronidazole).
Do not administer simultaneously with antacids such as aluminium hydroxide, etc.;
administer 2 hours apart.
Do not combine with: erythromycin and neuromuscular blocking drugs.
Reduce dosage in patients with hepatic impairment.
Pregnancy: no contra-indication
Breast-feeding: administer only if there is no therapeutic alternative. Check infant's stools (risk of
colitis).

Contra-indications, adverse effects, precautions

In some regions of South-East Asia, clindamycin is used in combination with quinine for
the treatment of malaria in pregnant women and children < 8 years as the association
quinine-doxycycline is contraindicated in these patients.
Storage: below 25C

Remarks

45

CLOMIPRAMINE
(Anafranil)

Prescription under medical supervision

Tricyclic antidepressant

Therapeutic action

Major depression
Prevention of panic attacks

Indications

25 mg tablet
Also comes in 10 mg tablet.

Presentation

Adult: initial dose of 25 mg once daily at bedtime, then increase gradually over one week
to 75 mg once daily at bedtime (max. 150 mg/day).
Reduce the dose by half in elderly patients and in patients with hepatic or renal impairment.

Dosage

Depression: 6 months minimum. The treatment should be discontinued gradually (dose


tapered over 4 weeks). If signs of relapse occur, increase the dose.
Prevention of panic attacks: 2 to 3 months once panic attacks cease then discontinue gradually
over 4 weeks.

Duration

Do not administer to patients with recent myocardial infarction, arrhythmia, closed-angle


glaucoma, prostate disorders.
Administer with caution and carefully monitor use in patients > 60 years and in patients with
epilepsy, chronic constipation, renal or hepatic impairment, history of bipolar disorders.
May cause:
drowsiness (caution when driving/operating machinery) or insomnia, orthostatic
hypotension, sexual dysfunction;
anticholinergic effects: dry mouth, blurred vision, constipation, tachycardia, disorders of
micturition. These adverse effects are transitory or disappear with dose reduction.
Treatment should be discontinued in the event of severe reactions (mental confusion,
urinary retention, cardiac rhythm disorders);
psychic disorders: exacerbation of anxiety, possibility of a suicide attempt at the beginning
of therapy, manic episode during treatment.
Do not combine with another antidepressant.
Monitor combination with CNS depressants (opioid analgesics, sedatives, H1 antihistamines, etc.), drugs known to have anticholinergic effects (atropine, carbamazepine,
chlorpromazine, promethazine, etc.), drugs which lower the seizure threshold (antipsychotics,
mefloquine, tramadol, etc.), lithium and other serotonergics.
Avoid alcohol during treatment.
Pregnancy: re-evaluate whether the treatment is still necessary; if it is continued, observe the newborn
infant the first few days (risk of neurological and gastrointestinal disorders).
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

The antidepressant effect is not immediate. It is necessary to wait 3 weeks before assessing
therapeutic efficacy. This must be explained to the patient.
Clomipramine causes less sedation, anticholinergic effects and orthostatic hypotension
than amitriptyline.
Storage: no special temperature requirements

Remarks

46

CLOXACILLIN
(Cloxapen, Orbenin)

Prescription under medical supervision

Penicillin antibacterial active against penicillinase-producing staphylococci

Therapeutic action

Non severe staphylococcal and/or streptococcal infections of the skin (impetigo, furunculosis,
carbuncle)

Indications

250 mg, 500 mg and 1 g capsules


Powder for oral suspension, 125 mg/5 ml

Presentation

Child and adult: 50 mg/kg/day in 3 divided doses (max. 3 to 4 g/day) for 7 to 10 days

Dosage and duration


AGE

3
months

WEIGHT

250 mg capsule

1 g capsule

500 mg capsule
125 mg/5 ml oral solution

1/2

tsp x 3

6
kg

2
years

13
kg

1 tsp x 3

7
years

2 tsp x 3

24
kg

15
years

2 cap x 3

55
kg

ADULT

4 cap x 3

1 cap x 3

2 cap x 3

1 cap x 3

Do not administer to penicillin-allergic patients.


Administer with caution to patients allergic to cephalosporins (cross-sensitivity may
occur); in neonates (risk of hyperbilirubinemia).
May cause: gastrointestinal disturbances, allergic reactions sometimes severe; rarely,
haematological disorders. In the event of allergic reactions, stop treatment immediately.
Reduce the dose by half in patients with renal impairment.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Take between meals.


Dicloxacillin (Diclocil, etc.) and flucloxacillin (Floxapen, etc.) are used for the same
indications.
Oxacillin should not be used by oral route since it is poorly absorbed.
Storage: below 25C

Remarks

47

CODEINE
Prescription under medical supervision
Opioid analgesic

Therapeutic action

Moderate pain, alone or in combination with a non-opioid analgesic

Indications

30 mg codeine phosphate tablet


Also comes in 1 mg/ml codeine phosphate syrup.

Presentation

Child from 6 months to 12 years: 0.5 to 1 mg/kg every 4 to 6 hours


Child over 12 years and adult: 30 to 60 mg every 4 to 6 hours; maximum 240 mg/day

Dosage

Duration: according to clinical evolution

Do not administer to patients with acute respiratory depression or asthma attack.


May cause:
constipation, nausea, vomiting, drowsiness, dizziness;
rarely: respiratory depression, allergic reactions, dependence, withdrawal syndrome.
Do not combine with:
other agonist opioids such as morphine (increased risk of respiratory depression);
agonist-antagonist opioids such as buprenorphine, nalbuphine, pentazocine (competitive
action).
Reduce dosage in patients with renal or hepatic impairment and in elderly patients.
Management of respiratory depression includes assisted ventilation and/or administration
of naloxone.
Pregnancy: no contra-indication. The newborn infant may develop withdrawal symptoms, respiratory
depression and drowsiness in the event of prolonged administration of large doses at the end of the
3rd trimester. In this event, closely monitor the newborn infant.
Breast-feeding: use with caution, for a short period (2-3 days), at the lowest effective dose. Monitor
the mother and the infant: in the event of excessive drowsiness, stop treatment.

Contra-indications, adverse effects, precautions

Administer systematically an appropriate laxative (e.g. lactulose) if analgesic treatment


continues more than 48 hours.
Codeine is also used for the short-term symptomatic treatment of dry, unproductive cough
in adult: 15 to 30 mg 3 to 4 times per day.
In some countries, codeine is on the list of narcotics: follow national regulations.
Storage: below 30C

Remarks

48

COTRIMOXAZOLE
= SULFAMETHOXAZOLE (SMX)/TRIMETHOPRIM (TMP)
(Bactrim)
Therapeutic action

Prescription under medical supervision

Combination of a sulfonamide with another antibacterial

Indications

First-line treatment of pneumocystosis and isosporiasis


Prophylaxis of pneumocystosis, toxoplasmosis and isosporiasis
Brucellosis (when doxycycline is contra-indicated)

Presentation

400 mg SMX + 80 mg TMP and 800 mg SMX + 160 mg TMP tablets


100 mg SMX + 20 mg TMP tablet for paediatric use
200 mg SMX + 40 mg TMP/5 ml oral suspension

Dosage and duration

Treatment of pneumocystosis
Child: 100 mg SMX + 20 mg TMP/kg/day in 2 divided doses
Adult: 4800 SMX + 960 TMP/day in 3 divided doses
Treatment of isosporiasis
Adult: 3200 mg SMX + 640 mg TMP/day in 2 divided doses
Prophylaxis of pneumocystosis, toxoplasmosis and isosporiasis
Child: 50 mg SMX + 10 mg TMP/kg once daily, as long as necessary
Adult: 800 mg SMX + 160 mg TMP once daily, as long as necessary
Brucellosis
Child: 40 mg SMX + 8 mg TMP/kg/day in 2 divided doses
Adult: 1600 mg SMX + 320 mg TMP/day in 2 divided doses

Duration

Pneumocystosis: 14 to 21 days depending on severity; isosporiasis: 10 days; brucellosis: 6 weeks

Contra-indications, adverse effects, precautions

Do not administer to children under 1 month.


Do not administer to sulfonamide-allergic patients; patients with severe renal or hepatic impairment.
May cause:
gastrointestinal disturbances, hepatic or renal disorders (crystalluria, etc.), metabolic
disorders (hyperkalaemia); neuropathy, photosensitivity, haemolytic anaemia in
patients with G6PD deficiency.
allergic reactions (fever, rash, etc.) sometimes severe (Lyell's and Stevens-Johnson
syndromes, haematological disorders, etc.). In these cases, stop treatment immediately.
megaloblastic anaemia due to folinic acid deficiency in patients receiving prolonged
treatment (in this event, administer calcium folinate).
Adverse effects occur more frequently in patients with HIV infection.
In the event of prolonged treatment, monitor blood count if possible.
Do not combine with methotrexate and phenytoin.
Avoid combination with drugs inducing hyperkalaemia: potassium, spironolactone, enalapril,
NSAIDs, heparin (increased risk of hyperkalaemia).
Monitor combination with zidovudine (increased haematotoxicity).
Drink a lot of liquid during treatment.
Pregnancy: no contra-indication. However, avoid using during the last month of pregnancy (risk of
jaundice and haemolytic anaemia in the newborn infant).
Breast-feeding: avoid if premature infant, jaundice, low-birth weight, infant under one month of age.
If cotrimoxazole is used, observe the infant for signs of jaundice.

Remarks

Storage: below 30C


Once the bottle has been opened, the oral suspension keeps for 20 days at ambient temperature or
40 days refrigerated (between 2C and 8C).

49

DAPSONE
(Avlosulfon, Disulone)

Prescription under medical supervision

Sulfone antibacterial

Therapeutic action

Prophylaxis of toxoplasmosis and pneumocystosis


Treatment of pneumocystosis
Paucibacillary and multibacillary leprosy, in combination with other antileprotics

Indications

25 mg, 50 mg and 100 mg tablets

Presentation

Prophylaxis of pneumocystosis only


Child: 2 mg/kg once daily, without exceeding 100 mg/day
Adult: 100 mg once daily
Prophylaxis of toxoplasmosis and pneumocystosis
Child: 2 mg/kg once daily, without exceeding 25 mg/day (in combination with pyrimethamine 1 mg/kg once daily + folinic acid 10 mg/week)
Adult:
50 mg once daily (in combination with pyrimethamine 50 mg/week + folinic acid 25 to
30 mg/week)
or 200 mg once weekly (in combination with pyrimethamine 75 mg/week + folinic acid
25 to 30 mg/week)
Treatment of pneumocystosis (in combination with 15 mg/kg/day of trimethoprime)
Child: 2 mg/kg once daily, without exceeding 100 mg/day
Adult: 100 mg once daily
Paucibacillary and multibacillary leprosy
Child under 10 years: 25 mg once daily
Child from 10 to 14 years: 50 mg once daily
Adult: 100 mg once daily

Dosage

Prophylaxis of toxoplasmosis and pneumocystosis: as long as necessary; treatment of pneumocystosis:


21 days; paucibacillary leprosy: 6 months; multibacillary leprosy: 12 months

Duration

Do not administer to patients with allergy to sulfones or severe anaemia (first treat anaemia).
Administer with caution to patients with renal or hepatic impairment.
May cause: haemolytic anaemia in patients with G6PD deficiency, dose-related haemolytic
anaemia, neutropenia, methaemoglobinaemia, pruritus, rash, gastrointestinal disturbances,
peripheral neuropathies, agranulocytosis; hypersensitivity reactions during the first month
of treatment (fever, jaundice, hepatitis, adenopathy, exfoliative dermatitis, etc.) requiring
permanent discontinuation of treatment.
Monitor blood count and transaminases if possible.
Do not administer simultaneously with didanosine: administer each drug 2 hours apart.
Monitor combination with zidovudine (increased haematological toxicity).
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

For the treatment of leprosy, dapsone must always be used in combination with rifampicin
(paucibacillary leprosy) or rifampicin + clofazimine (multibacillary leprosy) in order to
avoid the emergence of resistance.

Storage: below 25C

Remarks

50

Revised October 2014

DESOGESTREL
Prescription under medical supervision

Therapeutic action

Hormonal contraceptive, progestogen

Indications

Oral contraception

Presentation

75 micrograms (0.075 mg) tablet, 28-day pack

Dosage

1 tablet daily at the same time, continuously, including during menstruation


Start the first day of menstruation or immediately after abortion or as of the 21st day after
childbirth if the woman does not breastfeed.
It is also possible to start at any moment of the cycle (if the woman is not pregnant). In this
case, contraception will be effective as of the 3rd tablet. It is essential to use condoms during
the first 2 days.

Duration

If there are no adverse effects, as long as contraception is desired.

Contra-indications, adverse effects, precautions

Do not administer to women with breast cancer, severe or recent liver disease, unexplained
vaginal bleeding, current thromboembolic disorders.
May cause: amenorrhoea, menstrual disturbances, nausea, weight gain, breast tenderness,
mood changes, acne, headache.
Hepatic enzyme inducers (rifampicin, rifabutin, nevirapine, nelfinavir, ritonavir, phenobarbital,
phenytoin, carbamazepine, griseofulvin, etc.) reduce the contraceptive efficacy. Use copper
intrauterine device or condoms or injectable medroxyprogesterone.
Pregnancy: CONTRA-INDICATED
Breast-feeding: it is recommended to wait 6 weeks after childbirth before starting desogestrel in
breastfeeding women. However, if it is the only contraceptive method available or acceptable, it can
be started 3 weeks after childbirth.

Remarks

Desogestrel is a possible alternative when estroprogestogens are contra-indicated or poorly


tolerated. It is preferred to levonorgestrel as its contraceptive efficacy is similar to that of
estroprogestogens.
If a woman misses a tablet, she should take it as soon as possible and continue treatment
as normal. If she misses by over 12 hours, contraceptive protection will be lessened. It is
therefore recommended to use an additional contraceptive method: condoms for 7 days
and, if she has had sexual intercourse within 5 days before forgetting the tablet, emergency
contraception.
Storage: below 25C

51

DIAZEPAM
(Valium)

Prescription under medical supervision

Anxiolytic, sedative, anticonvulsant, muscle relaxant

Therapeutic action

Agitation and anxiety


Muscle spasms

Indications

5 mg tablet
Also comes in 2 mg and 10 mg tablets and 1% oral solution.

Presentation

Child: 0.5 mg/kg/day in 3 divided doses


Adult: 5 to 15 mg/day in 3 divided doses
Do not exceed indicated doses.

Dosage

AGE

WEIGHT

5 mg tablet

2
months

4
kg

1
year
8
kg

1/4

5
years
tab x 3

15
kg

1/2

15
years
tab x 3

35
kg

ADULT
1 tab x 3

Duration: according to clinical response ; the shortest duration possible.

Do not administer to patients with severe respiratory insufficiency or severe hepatic


impairment.
Administer only in exceptions and with caution to children.
May cause:
feeling of inebriation, drowsiness (administer with caution when driving or operating
machinery),
dependence and tolerance when used for more than 10-15 days. At the end of treatment,
reduce doses gradually to avoid withdrawal syndrome or rebound effect.
in the event of overdose: ataxia, muscular weakness, hypotension, confusion, lethargy,
respiratory depression, coma.
Reduce the dose by one half in elderly patients and in patients with renal or hepatic
impairment.
Risk of increased sedation when combined with alcohol and drugs acting on the central
nervous system: opioid analgesics, neuroleptics (chlorpromazine, haloperidol, etc.), antihistamines (chlorphenamine, promethazine), antidepressants (clomipramine, fluoxetine,
etc.), phenobarbital, etc.
Pregnancy: avoid
Breast-feeding: avoid

Contra-indications, adverse effects, precautions

Diazepam is subject to international controls: follow national regulations.


Diazepam is not a treatment for depression, chronic anxiety, or post-traumatic stress
syndrome.
Storage: below 30C

Remarks

52

DIDANOSINE = ddI
(Divir, Videx)

Prescription under medical supervision

Antiretroviral, HIV-1 and HIV-2 nucleoside reverse transcriptase inhibitor

Therapeutic action

HIV-1 or HIV-2 infection, in combination with other antiretroviral drugs

Indications

25 mg, 50 mg, 100 mg, 150 mg and 200 mg buffered tablets to be chewed or dispersed in at
least 30 ml water (15 ml in children under 1 year)
125 mg, 250 mg and 400 mg enteric-coated capsules, to be taken with at least 100 ml water

Presentation

Child under 3 months: 100 mg/m2/day in 2 divided doses


Child from 3 months to 12 years (or over 5 kg): 240 mg/m2 once daily or in 2 divided doses
Adult under 60 kg: 250 mg once daily or in 2 divided doses
Adult 60 kg and over: 400 mg once daily or in 2 divided doses

Dosage

Weight

Daily dose

20 to 24 kg

200 mg

5 to 14 kg

15 to 19 kg
25 to 59 kg
60 kg

100 mg

Tablets

Two 50 mg tab

150 mg

One 100 mg tab + one 50 mg tab

400 mg

Two 200 mg tab

250 mg

Two 100 mg tab

One 200 mg tab + one 50 mg tab

Duration: depending on the efficacy and tolerance of didanosine.

Capsules

One 250 mg cap


One 400 mg cap

Administer with caution to patients with history of pancreatitis or hepatic disorders.


May cause:
peripheral neuropathy, gastrointestinal disturbances (nausea, vomiting, diarrhoea, etc.),
and rarely ophthalmic disorders (particularly in children);
lactic acidosis, severe pancreatic or hepatic disorders (in these events, stop antiretroviral
treatment; once the symptoms have resolved, prescribe an antiretroviral regimen
without didanosine).
Do not combine with tenofovir; avoid combination with stavudine.
Reduce dosage in patients with renal impairment.
Do not administer simultaneously didanosine tablets with tetracyclines, fluoroquinolones
and medications that need stomach acid for absorption (itraconazole, dapsone, etc.). Wait
2 hours between the administration of didanosine and these medications. This precaution
does not apply to didanosine enteric-coated capsules.
When patients receive didanosine (tablets) and indinavir, administer first indinavir, wait
one hour, then administer didanosine.
Pregnancy: no contra-indication. Do not combine with stavudine.

Contra-indications, adverse effects, precautions

Didanosine should be taken 2 hours before (or at least 2 hours after) a meal.
Tablets: patients must always take at least two tablets at a time to provide sufficient antacid.
Also comes in powder for oral solution in 2 and 4 g vials to be diluted in an aluminium and
magnesium hydroxide suspension.
Storage: tablets: below 30C; capsules: below 25C

Remarks

53

DIETHYLCARBAMAZINE
(Diethizine, Hetrazan, Notezine...)

Prescription under medical supervision

Anthelminthic (antifilarial)

Therapeutic action

Lymphatic filariasis

Indications

50 mg and 100 mg tablets

Presentation

Child under 10 years: 0.5 mg/kg as a single dose on the first day, then increase the dose
gradually over 3 days to 3 mg/kg/day in 3 divided doses
Child over 10 years and adult: 1 mg/kg as a single dose on the first day, then increase the
dose gradually over 3 days to 6 mg/kg/day in 3 divided doses

Dosage

Wuchereria bancrofti: 12 days


Brugia malayi and timori: 6 to 12 days

Duration

Do not administer to patients with onchocerciasis or heavy Loa loa microfilareamia; to


infants, elderly patients and patients with heart or renal diseases.
Do not administer during an acute attack.
Administer with caution in patients with history of seizures.
May cause:
nausea, vomiting, headache, dizziness, drowsiness, fever, joint pain, urticaria, transient
haematuria, subcutaneous nodules, lymphangitis, localized oedema;
in patients with associated onchocerciasis: severe ocular damages (optic nerve lesions,
retinal lesions);
in patients with associated loiasis: encephalitis (potentially fatal) if Loa loa microfilaraemia
is high.
Reduce dosage in patients with renal impairment.
Pregnancy: CONTRA-INDICATED (treatment may be deferred until after delivery)
Breast-feeding: not recommended

Contra-indications, adverse effects, precautions

In countries with a national programme for the elimination of bancroftian filariasis, the
combination diethylcarbamazine + albendazole is administered as a single annual dose for
4 to 6 years. This regimen is only suitable for countries that are free from Onchocerca volvulus
and/or Loa loa.
Diethylcarbamazine is included in the WHO complementary list of essential medicines.
Storage: between 15C and 30C

Remarks

54

DIGOXIN
(Coragoxine, Lanoxin)

Prescription under medical supervision

Cardiotonic

Therapeutic action
Supraventricular arrhythmias (fibrillation, flutter, paroxysmal tachycardia)
Heart failure

Indications

62.5 g (0.0625 mg) and 250 g (0.25 mg) tablets


Also comes in 50 g/ml oral solution (0.05 mg/ml).

Presentation

Adult:
loading dose: 750 to 1500 g (0.75 to 1.5 mg) in 3 to 4 divided doses. Do not exceed 1500 g
during the first 24 hours.
maintenance dose: 125 to 250 g/day (0.125 to 0.25 mg) once daily or in 2 divided doses

Dosage

Reduce the dose by one half in elderly patients and in patients with renal impairment.
According to clinical response

Duration

Do not administer to patients with bradycardia, ill defined arrhythmia, coronary artery
disease.
It is essential to monitor pulse in the initial stage of treatment.
Narrow margin between therapeutic and toxic dose.
May cause in the event of overdose: gastrointestinal disturbances (nausea, vomiting,
diarrhoea), blurred vision, headache, confusion, conduction and rhythm disorders. If so,
reduce dose or stop treatment.
Do not combine with calcium, particularly by IV route (serious arrhythmias).
Monitor combination with:
amiodarone, macrolides, itraconazole, quinine, chloroquine (increased digoxin concentration),
potassium-depleting drugs: diuretics, corticoids, amphotericin B (increased risk of
digoxin toxicity).
Monitor if possible serum potassium level in patients taking potassium-depleting drugs
and serum creatinine level in patients with renal impairment.
Do not administer simultaneously with antacids such as aluminium hydroxide, etc.,
administer 2 hours apart.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

A loading dose may be administered in arrhythmias if a rapid digitalisation is required. It


is usually not necessary for heart failure.
Storage: below 30C

Remarks

55

DIHYDROARTEMISININ/PIPERAQUINE = DHA/PPQ
(Eurartesim)

Prescription under medical supervision

Antimalarial

Therapeutic action
Treatment of uncomplicated falciparum malaria
Completion treatment following parenteral therapy for severe falciparum malaria

Indications

Co-formulated tablets of dihydroartemisinin (DHA)/piperaquine (PPQ), in blister pack,


for a complete treatment for one individual
There are 5 different blister packs corresponding to 6 categories of weight:
20 mg DHA/160 mg PPQ tablets
blister pack of 3 tablets
40 mg DHA/320 mg PPQ tablets
blister pack of 3 tablets
40 mg DHA/320 mg PPQ tablets
blister pack of 6 tablets
40 mg DHA/320 mg PPQ tablets
blister pack of 9 tablets
40 mg DHA/320 mg PPQ tablets
blister pack of 12 tablets

Presentation

Tablets are to be taken once daily for 3 days.

Dosage and duration


Weight

20 mg/160 mg tablet

40 mg/320 mg tablet

7 to 12 kg

1 tab

5 to 6 kg

13 to 23 kg
24 to 35 kg
36 to 74 kg

75 to 100 kg

1/2

tab

1 tab

3 tab

2 tab
4 tab

Do not administer in the event of cardiac disorders (bradycardia, heart rhythm disorders,
congestive heart failure).
Administer with caution to patients > 60 years or with renal or hepatic impairment.
May cause: cardiac disorders (QT prolongation, tachycardia); rarely, gastrointestinal
disturbances, pruritus, hepatic disorders, joint and muscle pain.
Do not combine with drugs that prolong the QT interval (amiodarone, erythromycin,
haloperidol, pentamidine, fluconazole).
Monitor combination with: antiretrovirals (increased blood levels of these drugs), rifampicin,
carbamazepine, phenytoin, phenobarbital (reduced blood levels of DHA/PPQ).
If the patient vomits within 30 minutes after administration, repeat the full dose; if the
patient vomits within one hour, re-administer half the dose.
Pregnancy: CONTRA-INDICATED (safety is not established)
Breast-feeding: no contraindication

Contra-indications, adverse effects, precautions

The dosage in children from 6 months of age and adults is 2 to 10 mg/kg/day of DHA and
16 to 26 mg/kg/day of PPQ.
Take between meals, with a glass of water.
The tablets may be crushed and mixed with water.

Storage: below 30C

Remarks

56

Revised June 2015

DOXYCYCLINE

Therapeutic action

Prescription under medical supervision

Cycline antibacterial

Indications

Cholera, louse-borne and tick-borne relapsing fevers, epidemic typhus and other rickettsioses,
bubonic plague, brucellosis (in combination with streptomycin), lymphogranuloma venereum
Lymphatic filariasis, alternative to ivermectin in onchocerciasis
In combination with quinine in P. falciparum multiresistant malaria (South-East Asia and
Amazon region), P. falciparum malaria prophylaxis
Alternative to first-line treatments of leptospirosis, treponematosis, atypical pneumonia
(Mycoplasma pneumonia, Chlamydophila pneumonia), cervicitis and urethritis due to Chlamydia
trachomatis (in combination with a treatment for gonorrhoea), donovanosis, syphilis, animal
bites (if antibiotic therapy is indicated)

Presentation

100 mg tablet

Dosage

Louse-borne relapsing fever, epidemic typhus, cholera


Child over 8 years: 100 mg as a single dose
Adult: 200 mg as a single dose (300 mg as a single dose in cholera)
Malaria prophylaxis
Child over 8 years and less than 40 kg: 50 mg once daily
Child over 40 kg and adult: 100 mg once daily
Other indications
Child over 8 years: 100 mg (up to 200 mg in severe infections) once daily or in 2 divided
doses
Adult: 200 mg once daily or in 2 divided doses

Duration

Tick-borne relapsing fever, animal bites, leptospirosis, rickettsiosis, cervicitis and urethritis due to
C. trachomatis, malaria treatment: 7 days; bubonic plague: 10 days; atypical pneumonia: 10-14 days;
syphilis, Bejel, Pinta, lymphogranuloma venereum: 14 days; lymphatic filariasis, onchocerciasis:
minimum 4 weeks; brucellosis: 6 weeks; donovanosis: until complete healing of lesions; malaria
prophylaxis: start 24 hours before departure and continue 4 weeks after the return.

Contra-indications, adverse effects, precautions

Do not administer to children under 8 years (may damage teeth) and patients with allergy
to tetracycline.
Administer with caution to patients with hepatic or renal impairment.
May cause: gastrointestinal disturbances, allergic reactions, photosensitivity (protect exposed
skin from sun exposure), oesophageal ulcerations (take tablets during meals with a glass of
water in a upright position and more than 1 hour before going to bed).
Do not give simultaneously with ferrous salts, zinc, calcium, antiacids (aluminium or
magnesium hydroxide, etc.): administer 2 hours apart.
Monitor combination with hepatic enzyme inducers: rifampicin, rifabutin, nevirapine,
nelfinavir, ritonavir, phenobarbital, phenytoin, carbamazepine, griseofulvin, etc. (reduction
of the doxycycline efficacy).
Pregnancy: CONTRA-INDICATED during the 2nd and 3rd trimester (except if single dose treatment)
Breast-feeding: avoid (risk of infant teeth discoloration)

Remarks

Also comes in 50 mg tablets, and 25 mg/5 ml and 50 mg/5 ml oral solutions.


Storage: below 25C

59

EFAVIRENZ = EFV = EFZ


(Aviranz 600, Efavir 600, Stocrin, Sustiva)

Prescription under medical supervision

Therapeutic action

Antiretroviral, HIV-1 non nucleoside reverse transcriptase inhibitor

Indications

HIV-1 infection, in combination with other antiretroviral drugs

Presentation

50 mg, 100 mg and 200 mg capsules and 50 mg, 200 mg and 600 mg tablets
30 mg/ml oral solution

Dosage

The dose is given once daily at bedtime:


Weight

Oral solution 30 mg/ml

Capsules or tablets

15 to 19 kg

10 ml

250 mg

25 to 32 kg

15 ml

10 to 14 kg
20 to 24 kg
33 to 39 kg
40 kg

9 ml

12 ml

Duration: depending on the efficacy and tolerance of efavirenz.

200 mg
300 mg
350 mg
400 mg
600 mg

Contra-indications, adverse effects, precautions

Do not administer to children under 3 years.


Avoid administration in patients with severe hepatic impairment.
Administer with caution to patients with psychiatric disorders (or history of) or epilepsy.
Do not combine with amodiaquine.
May cause:
neurological disorders (dizziness, insomnia, drowsiness, abnormal dreaming, impaired
concentration, seizures);
psychiatric disorders (severe depression, suicidal ideation);
raised liver enzymes (ALAT);
skin reactions, possibly severe (Stevens-Johnson syndrome).
When efavirenz is used concomitantly with oestrogen-progestogen oral contraceptives:
increased risk of thromboembolism due to ethinylestradiol.
Pregnancy: avoid; effective contraception must be used during treatment.

Remarks

Oral solution requires higher doses than capsules or tablets.


Also comes in fixed-dose combination tablet containing efavirenz-zidovudine-lamivudine.
Storage: below 30C
Once opened, oral solution keeps for 30 days maximum.

58

ENALAPRIL
(Renitec)

Prescription under medical supervision

Antihypertensive, vasodilator (angiotensin-converting enzyme inhibitor)

Therapeutic action

Hypertension
Congestive heart failure

Indications

2.5 mg, 5 mg and 20 mg tablets

Presentation

Hypertension
Adult: initially 5 mg once daily, then increase the dose every 1 to 2 weeks, according to
blood pressure, up to 10 to 40 mg once daily or in 2 divided doses
In elderly patients, patients taking a diuretic or patients with renal impairment: start with
2.5 mg once daily as there is a risk of hypotension and/or acute renal impairment.

Dosage and duration

Congestive heart failure


Adult: 2.5 mg once daily, then increase the dose over 2 to 4 weeks, up to 10 to 20 mg once
daily or in 2 divided doses

Do not administer to patients with history of hypersensitivity to enalapril.


May cause:
hypotension, dry cough at night, hyperkalaemia, headache, dizziness, nausea, renal
impairment,
allergic reactions, angioedema,
rarely: hepatitis, neutropenia and agranulocytosis in immunodeficient patients, anaemia
in patients with chronic renal impairment.
Reduce dosage in patients with renal impairment.
Do not combine with potassium-sparing diuretics (spironolactone) or potassium.
Monitor, if possible, serum creatinine and potassium levels (hyperkalaemia is frequent but
of no concern if it remains below 5.5 mEq/litre).
In patients taking a diuretic, reduce the dose of the diuretic when adding enalapril.
Pregnancy: CONTRA-INDICATED
Breast-feeding: no contra-indication at recommended doses

Contra-indications, adverse effects, precautions

Captopril (Lopril, etc.) has the same indications as enalapril, however its dosage differs
and it must be taken 2 to 3 times daily.
Storage: below 30C

Remarks

59

ERGOCALCIFEROL = VITAMIN D2
and COLECALCIFEROL = VITAMIN D3

Prescription under medical supervision

Vitamin necessary for the intestinal absorption of calcium and phosphate and for normal
bone calcification

Therapeutic action

Prevention and treatment of vitamin D deficiencies (rickets, osteomalacia)

Indications

1.25 mg tablet or capsule (50 000 IU)


250 g/ml oral suspension (10 000 IU/ml)
Also comes in different strengths, depending on the manufacturers.

Presentation

Ergocalciferol and colecalciferol are used at the same doses:

Dosage and duration

Prevention of vitamin D deficiencies


50 000 IU tablet or capsule:
Child under 5 years: 100 000 IU every 3 months, during periods of limited sunlight
Child over 5 years and adult: 100 000 IU every 3 months or 200 000 IU every 6 months
Pregnant woman: 100 000 IU around the 6th-7th month of pregnancy
10 000 IU/ml oral suspension:
Child and adult: 400 IU once daily (10 g daily) during periods of limited sunlight
For children rarely exposed to sunlight or dark-skinned children, doses may be doubled.

Treatment of vitamin D deficiencies


Child and adult: 800 to 4000 IU once daily (20 to 100 g daily) for 6 to 12 weeks, then
continue with preventive dose
Do not exceed 600 000 IU/year.

Do not administer to patients with hypercalcaemia, hypercalciuria, calcic lithiasis.


Stop treatment if signs of overdosage occur: headache, anorexia, nausea, vomiting, increased
thirst, polyuria.
Avoid combination with thiazide diuretics (hydrochlorothiazide, etc.).
Monitor, if possible, calcaemia and calciuria during curative treatment.
Combine with a calcium supplementation at the start of curative treatment (500 mg to
1 g/day).
Pregnancy: no contra-indication
Breast-feeding: no contra-indication. When curative treatment is being administered to the mother,
do not give vitamin D to the child.

Contra-indications, adverse effects, precautions

The number of IU per drop of oral solution varies according to manufacturers. Check
instructions for use.
Vitamin D2 and D3 also come in ampoules for oral and/or parenteral use.
Storage: below 25C
Once opened, oral solution keeps 3 months.

Remarks

60

Revised February 2015

ERYTHROMYCIN
Prescription under medical supervision

Therapeutic action

Macrolide antibacterial

Indications

Erythromycin is an alternative to first-line antibacterials when they are not available or


contra-indicated:
Borreliosis (louse-borne and tick-borne relapsing fevers), non-venereal treponematoses,
leptospirosis, conjunctivitis due to Chlamydia trachomatis
Acute otitis media, tonsillitis and sinusitis; diphtheria, pertussis, pneumonia due to
Mycoplasma pneumoniae and Chlamydophila pneumoniae
Erysipela, impetigo, furuncle, cutaneous anthrax, leg ulcer
Cervicitis and urethritis due to Chlamydia trachomatis (in combination with a treatment for
gonorrhoea), donovanosis, chancroid, lymphogranuloma venereum, syphilis
Completion treatment following parenteral therapy with erythromycin

Presentation

250 mg and 500 mg tablets


125 mg/5 ml powder for oral suspension, to be reconstituted with filtered water

Dosage

Louse-borne relapsing fever


Child under 5 years: 250 mg as a single dose
Child over 5 years and adult: 500 mg as a single dose
Other indications
Child: 30 to 50 mg/kg/day in 2 or 3 divided doses
Age
< 2 months
2 to < 12 months
1 to < 3 years
3 to < 8 years
8 to < 11 years
11 to < 13 years

Weight
< 5 kg
5 to < 10 kg
10 to < 15 kg
15 to < 25 kg
25 to < 35 kg
35 to < 45 kg

125 mg/5 ml susp.


tsp x 2
1 tsp x 2
2 tsp x 2
2 tsp x 3

Adult: 2 to 3 g/day in 2 or 3 divided doses

Duration

250 mg tablet
tab x 2
tab x 2
1 tab x 2
1 tab x 3
2 tab x 2
2 tab x 3

500 mg tablet

tab x 2
tab x 2
tab x 3
1 tab x 2
1 tab x 3

Tick-borne relapsing fever, leptospirosis, pertussis, cervicitis and urethritis, chancroid, impetigo,
furuncle, leg ulcer: 7 days; sinusitis, erysipela, cutaneous anthrax: 7 to 10 days; tonsillitis, otitis:
10 days; atypical pneumonia:10 to 14 days; diphtheria, treponematoses, syphilis, lymphogranuloma
venereum, donovanosis, conjunctivitis due to C. trachomatis: 14 days.

Contra-indications, adverse effects, precautions

Do not administer to patients with allergy to erythromycin or another macrolide.


Administer with caution to patients with renal impairment (max. 1.5 g/day for adult with
severe renal impairment) or hepatic impairment.
May cause: gastrointestinal disturbances, reversible hearing disorders, heart rhythm disorders
(QT prolongation); allergic reactions sometimes severe. In the event of allergic reaction,
stop treatment immediately.
Avoid combination with drugs that prolong the QT interval (amiodarone, chloroquine, coartemether, fluconazole, haloperidol, mefloquine, moxifloxacin, ondansetron, pentamidine,
quinine, etc.).
Administer with caution and monitor use in patients taking carbamazepine or digoxin
(increased their plasma levels).
Avoid use in neonates less than 2 weeks (risk of pyloric stenosis).
Pregnancy and breast-feeding: no contra-indication

Remarks

Take tablets preferably one hour before or 2 hours after a meal.


Storage: below 25C

For the oral suspension (powder or reconstituted suspension): follow manufacturers instructions.

61

ETHAMBUTOL = E
Prescription under medical supervision
First line antituberculous antibacterial (bacteriostatic activity)

Therapeutic action

Treatment of tuberculosis, in combination with other antituberculous antibacterials

Indications

100 mg and 400 mg tablets

Presentation

Child under 30 kg: 20 mg/kg (15 to 25 mg/kg/day) once daily


Child over 30 kg and adult: 15 mg/kg (15 to 25 mg/kg/day) once daily
Maximum dose: 1200 mg/day

Dosage

According to protocol

Duration

Do not administer to patients with severe renal impairment or pre-existing optic neuritis
(e.g. diabetic retinopathy).
Reduce the dose in patients with renal impairment (15 to 25 mg/kg/dose 3 times per
week).
May cause: retrobulbar optic neuritis. Patients should be warned that they must immediately
stop treatment and seek medical attention in the event of visual disturbances such as blurred
vision, reduced visual acuity, blind spot (scotoma), green-red colour blindness. Visual
alterations are usually reversible a few weeks after stopping ethambutol.
The dosage must be carefully adjusted to the body weight (adverse effects are dosedependant), especially for children under 5 years, as it is more difficult to detect visual
alterations at this age.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Ethambutol is included in the WHO Group 1 antituberculous agents.


For patients on first-line antituberculous treatment, ethambutol is given as part of a fixed
dose combination (isoniazid+rifampicin+pyrazinamide+ethambutol or isoniazid+ethambutol).

Storage: below 30C

Remarks

62

Revised October 2014

ETHINYLESTRADIOL/LEVONORGESTREL

Therapeutic action

Prescription under medical supervision

Combined hormonal contraceptive, estrogen-progestogen

Indications

Oral contraception

Presentation

21-day pack: 21 active tablets of 30 micrograms ethinylestradiol + 150 micrograms levonorgestrel


28-day pack: 21 active tablets of 30 micrograms ethinylestradiol + 150 micrograms levonorgestrel
and 7 inactive tablets

Dosage

21-day pack: 1 tablet daily at the same time, for 21 days, followed by a tablet-free interval
of 7 days
28-day pack: 1 tablet daily at the same time, with no interruption, even during menstruation
Start the first day of menstruation or immediately after abortion or as of the 21st day after
childbirth if the woman does not breastfeed.
It is also possible to start at any moment of the cycle (if the woman is not pregnant). In this
case, contraception will be effective as of the 8th tablet. It is essential to use condoms during
the first 7 days.

Duration: if there are no adverse effects, as long as contraception is desired.


Contra-indications, adverse effects, precautions

Do not administer to women with breast cancer, uncontrolled hypertension, uncontrolled or


complicated diabetes, history of thromboembolic disorders, coronary insufficiency, valvular
disease, stroke, severe or recent liver disease, unexplained vaginal bleeding, migraine with
neurological signs, renal impairment, hyperlipidaemia, to women smokers over age 35.
May cause: reduced menstrual flow, vaginal candidiasis, nausea, weight gain, breast
tenderness, mood changes, acne and headache. Other rare and severe adverse effects require
discontinuation of treatment: hypertension, cardiovascular and thromboembolic disorders,
jaundice, migraine, visual disturbances.
Hepatic enzyme inducers (rifampicin, rifabutin, nevirapine, nelfinavir, ritonavir, phenobarbital,
phenytoin, carbamazepine, griseofulvin, etc.) reduce the contraceptive efficacy. Use a nonhormonal contraceptive method (copper intrauterine device, condoms) or injectable
medroxyprogesterone, or as a last resort an oral contraceptive containing 50 micrograms
ethinylestradiol (however there is a risk of contraceptive failure and risk of adverse effects is
increased).
Clinical examinations must be carried out before (blood pressure, breasts) and during
treatment (blood pressure).
Pregnancy: CONTRA-INDICATED
Breast-feeding: CONTRA-INDICATED before 6 weeks; not recommended between 6 weeks and 6 months
(except if it is the only available or acceptable contraceptive method); no contra-indication after
6 months.

Remarks

If a woman misses an active tablet, she should take it as soon as possible and continue
treatment as normal. If she misses by over 12 hours, contraceptive protection will be lessened.
It is therefore recommended to use an additional contraceptive method: condoms for 7 days
and, if she has had sexual intercourse within 5 days before forgetting the tablet, emergency
contraception.
28-day packs can simplify use as there is no interruption between two packs. Explain to the
woman which are active and inactive tablets. She must be careful not to start with inactive tablets.
Storage: below 25C

63

FERROUS SALTS

Antianaemia drug

Therapeutic action

Prevention and treatment of iron-deficiency anaemia

Indications

200 mg ferrous sulfate tablet containing 65 mg of elemental iron


Also comes in syrup and in different compositions and strengths.

Presentation

Dosage (expressed in elemental iron)

Prevention of iron-deficiency anaemia


Child under 5 years: 15 to 30 mg once daily
Child over 5 years: 30 mg once daily
Pregnant woman: 60 mg once daily

Treatment of iron-deficiency anaemia


Child under 2 years: 30 mg once daily
Child from 2 to 12 years: 60 mg once daily
Adult: 120 to 180 mg/day in 2 to 3 divided doses
Do not exceed indicated doses.

= 1/4 to 1/2 tab/day


= 1/2 tab/day
= 1 tab/day
= 1/2 tab/day
= 1 tab/day
= 2 to 3 tab/day

Prevention: during risk period (pregnancy, malnutrition)


Treatment: 3 months

Duration

Do not administer to patients with sickle-cell anaemia.


May cause: gastrointestinal disturbances (epigastric pain, diarrhoea or constipation, black
stools).
Do not exceed recommended doses, especially in children.
Toxic dose: 30 mg/kg of elemental iron (100 mg/kg of ferrous sulfate).
Signs of overdose: bloody diarrhoea, heart failure.
Absorption of both ferrous salts and doxycycline or antacids is decreased when they are
given concomitantly. Administer each drug at least 2 hours apart.
Do not administer simultaneously with doxyccline or antacids: administer 2 hours apart.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Take during meals to reduce gastrointestinal disturbances.


For treatment, preferably use tablets containing both ferrous salts and folic acid.
Other ferrous salts may be used. Ensure the dose of elemental iron is the same as that
indicated above (200 mg ferrous fumarate = 65 mg elemental iron; 300 mg ferrous gluconate
= 35 mg elemental iron).
Storage: below 30C

Remarks

64

FLUCONAZOLE
(Triflucan)

Prescription under medical supervision

Antifungal

Therapeutic action

Oesophageal candidiasis
Oropharyngeal candidiasis in immunocompromised patients, if local treatment fails
Secondary prophylaxis of recurrent candidiasis in immunocompromised patients
Cryptococcocal meningitis, after treatment with amphotericin B + flucytosine or in
combination with amphotericin B
Secondary prophylaxis of cryptococcocal infections

Indications

50 mg, 100 mg and 200 mg capsules or tablets


50 mg/5 ml oral solution

Presentation

Oesophageal candidiasis, second-line treatment of oropharyngeal candidiasis, secondary prophylaxis


of candidiasis
Child over 1 week: 3 to 6 mg/kg once daily
Adult: 50 to 200 mg once daily
These doses may be increased up to 400 mg/day if necessary. The treatment lasts 14 to
21 days for oesophageal candidiasis; 7 to 14 days for oropharyngeal candidiasis; as long as
required for secondary prophylaxis.

Dosage and duration

Cryptococcocal meningitis

After treatment with


amphotericin B + flucytosine
or

In combination with
amphotericin B

Child > 1 week

6 to 12 mg/kg once daily (max.


800 mg/day) for 8 weeks

Child > 1 week

12 mg/kg once daily (max.


800 mg/day) for 2 weeks (with
amphotericin B) then 6 to 12 mg/kg
once daily for 8 weeks

Adult

Adult

400 to 800 mg once daily for 8 weeks

800 mg once daily for 2 weeks (with


amphotericin B) then 400 to 800 mg
once daily for 8 weeks

Secondary prophylaxis of cryptococcocal infections


Child: 6 mg/kg once daily (max. 200 mg/day), as long as required
Adult: 200 mg once daily, as long as required

65

Administer with caution to patients with hepatic or renal impairment, cardiac disorders
(bradycardia, heart rhythm disorders, etc.). Reduce the dose by half in patients with renal
impairment.
May cause: gastrointestinal disturbances, headache, skin reactions sometimes severe,
anaphylactic reactions; severe hepatic disorders, haematologic (leukopenia, thrombocytopenia)
and cardiac disorders (QT-prolongation). Stop treatment in the event of anaphylactic reaction,
hepatic disorders or severe skin reaction.
In the event of prolonged treatment, monitor hepatic function.
Do not administer simultaneously with rifampicin, administer 12 hours apart (rifampicin
in the morning, fluconazole in the evening).
Avoid or monitor combination with:
drugs that prolong the QT interval (amiodarone, chloroquine, erythromycin, haloperidol,
mefloquine, pentamidine, quinine);
warfarin, carbamazepine, phenytoin, rifabutin, benzodiazepines, calcium-channel
blockers, certain antiretrovirals (e.g. nevirapine, saquinavir, zidovudine): increased
blood concentration of these drugs.
Pregnancy and breast-feeding: to be used only in severe or life-threatening infections, particularly
during the first trimester of pregnancy (risk of foetal malformations).

Contra-indications, adverse effects, precautions

For cryptococcocal meningitis, when amphotericin B is not available or not tolerated,


fluconazole may be administered alone:
Child over 1 week: 12 mg/kg once daily (max. 1200 mg/d) for 2 weeks then, 12 mg/kg
once daily (max. 800 mg/d) for 8 weeks
Adult: 1200 mg once daily for 2 weeks then, 800 mg once daily for 8 weeks
For the treatment of histoplasmosis, fluconazole is less effective than itraconazole. It should
be used (child: 10 to 12 mg/kg once daily, max. 400 mg/d ; adult: 400 mg on Day 1 then
200 to 400 mg once daily, for 6 to 12 weeks) only in patients unable to tolerate itraconazole.
For the treatment of dermatophytosis of the scalp, fluconazole may be used as a secondary
option (child: 6 mg/kg once daily, max. 200 mg/d; adult: 200 mg once daily, for 2 to
4 weeks) but itraconazole is preferred for this indication.
For the treatment of genital candidiasis (vulvovaginitis, balanitis), fluconazole is only used
if local treatment fails: 150 mg as a single dose in adults.
Storage: below 30C
Once reconstituted, oral solution keeps for 2 weeks.

Remarks

66

FLUCYTOSINE
(Ancobon, Ancotil)

Prescription under medical supervision

Antifungal

Therapeutic action
Cryptococcocal meningitis (induction phase), in combination with amphotericin B

Indications

500 mg capsule
Also comes in 250 mg capsule and 500 mg tablet.

Presentation

Child over 1 week and adult: 100 mg/kg/day in 4 divided doses for 2 weeks, in combination
with amphotericin B

Dosage and duration

Administer with caution and monitor use in patients > 60 years or with renal impairment
or haematological disorders.
Reduce the dose by half (50 mg/kg/day in 2 divided doses) in patients with renal
impairment.
May cause: gastrointestinal disturbances, haematological disorders (leukopenia, thrombocytopenia, less frequently, agranulocytosis), increase in transaminase levels, allergic
reactions sometimes severe; sometimes, confusion and hallucinations.
Monitor blood count and liver and renal function until the end of treatment.
Pregnancy and breast-feeding: flucytosine is generally not recommended. It is teratogenic in animals
and its safety in pregnant or lactating women has not been established. However, taking into account
the severity of the disease, the potential benefit of treatment for the mother and in the absence of a
safer alternative, it may be used despite the potential risks for the child.

Contra-indications, adverse effects, precautions

If amphotericin B is not available, flucytosine may be used at the same dose in combination
with fluconazole.
For children, tablets may be crushed.
Storage: below 25C

Remarks

67

FLUOXETINE
(Fluctine, Prozac)

Prescription under medical supervision

Antidepressant, selective serotonin re-uptake inhibitor (SSRI)

Therapeutic action

Major depression

Indications

20 mg capsule

Presentation

Adult: 20 mg once daily in the morning


Administer 20 mg on alternate days to patients with hepatic impairment or severe renal
impairment.

Dosage

6 months minimum. The treatment should be discontinued gradually (20 mg on alternate


days for 2 weeks). If signs of relapse occur, increase the dose.

Duration

Administer with caution and monitor use in patients with epilepsy, diabetes, history of
gastrointestinal bleeding or bipolar disorders.
May cause:
allergic reactions (rare): stop treatment;
insomnia or drowsiness (caution when driving/operating machinery), gastrointestinal
disturbances (take during a meal), headache, dizziness, blurred vision;
psychic disorders: exacerbation of anxiety, possibility of a suicide attempt at the beginning
of therapy, manic episode during the course treatment;
withdrawal symptoms (dizziness, paresthesia, nightmares, etc.) possible if the treatment
is discontinued abruptly.
Do not combine with another antidepressant.
Monitor combination (up to 5 weeks after the discontinuation of fluoxetine) with:
carbamazepine, haloperidol, risperidone, phenytoin (increases they toxicity), drugs which
lower the seizure threshold (antispychotics, mefloquine, tramadol, etc.), lithium and other
serotonergics.
Avoid aspirin and NSAIDs (risk of bleeding) and alcohol during treatment.
Pregnancy: re-evaluate whether the treatment is still necessary; if it is continued, observe the newborn
infant if the mother was under treatment in the 3rd trimester (risk of irritability, tremors, hypotony,
sleeping disorders, etc.).
Breast-feeding: avoid. Prefer paroxetine or amitriptyline.

Contra-indications, adverse effects, precautions

Do not open the capsules.


The antidepressant effect is not immediate. It is necessary to wait 3 weeks before assessing
therapeutic efficacy. This must be explained to the patient.
In case of insufficient response after 4 weeks, dosage may be increased to 40 mg/day,
except in patients with hepatic impairment or severe renal impairment.
In elderly patients, SSRI are preferred to tricyclics (less contraindications, less adverse
effects).
Storage: below 30C

Remarks

68

FOLIC acid = VITAMIN B9


Prescription under medical supervision

Antianaemia drug

Therapeutic action

Treatment of folate-deficient megaloblastic anaemias: severe malnutrition, repeated attacks


of malaria, intestinal parasitosis, etc.

Indications

1 mg and 5 mg tablets

Presentation

Child under 1 year: 0.5 mg/kg once daily for 4 months


Child over 1 year and adult: 5 mg once daily for 4 months; 15 mg once daily in malabsorption states

Dosage and duration

AGE

WEIGHT

5 mg tablet

2
months

1/2

tab

4
kg

1
year

1 tab

8
kg

5
years

1 tab

15
kg

15
years

1 tab

35
kg

ADULT
1 tab

Do not combine with sulfadiazine-pyrimethamine in patients with toxoplasmosis nor


sulfadoxine-pyrimethamine (Fansidar) in patients with malaria: folic acid reduces the
efficacy of these treatments.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Folic acid must not be used for the treatment of anaemia due to antifolates (pyrimethamine,
trimethoprim or methotrexate). Use folinic acid.
Folic acid is also used for primary and secondary prophylaxis of neural tube defects and
for prophylaxis of acute anaemia in patients with sickle-cell anaemia.
Storage: below 30C

Remarks

FERROUS SALTS/FOLIC acid


Prevention of iron and folic acid deficiency, mainly during pregnancy
Treatment of iron deficiency

Indications

Tablet of 200 mg ferrous sulfate (65 mg of elemental iron) + 400 g folic acid

Presentation

See ferrous salts

Dosage

This fixed-dose combination is not effective for the treatment of folic acid deficiency because
of its low dose.
Storage: below 30C

Remarks

69

Revised September 2015

FOSFOMYCIN TROMETAMOL
Prescription under medical supervision

Therapeutic action

Phosphonic acid antibacterial

Indications

Acute uncomplicated cystitis in women, without fever nor flank pain


Asymptomatic bacteriuria in pregnant women

Presentation

Granules for oral solution in 3 g sachet, to be dissolved in filtered water

Dosage and duration

3 g as a single dose

Contra-indications, adverse effects, precautions

Do not administer to patients with severe renal impairment, allergy to fosfomycin.


May cause: gastrointestinal disturbances, skin rash; rarely, allergic reactions.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Remarks

In the treatment of cystitis, symptoms should improve within 3 days of treatment. If not,
the patient should consult again. Treatment failure may be due to the presence of naturally
fosfomycin-resistant organisms (Staphylococcus saprophyticus).
Take between meals or at bedtime (food decreases absorption).
Fosfomycin is not included in the WHO list of essential medicines.

Storage: below 25C

70

FUROSEMIDE = FRUSEMIDE
(Lasilix, Lasix, Seguril)

Prescription under medical supervision

Diuretic

Therapeutic action
Oedema caused by renal, hepatic or congestive heart failure
Hypertension (prefer hydrochlorothiazide for this indication)

Indications

40 mg tablet
Also comes in 20 mg tablet.

Presentation

Child: 1 to 2 mg/kg once daily


Adult: 20 to 40 mg once daily

Dosage
AGE

WEIGHT

40 mg tablet

2
months
4
kg

1
year
8
kg

5
years

1/4

tab

15
kg

15
years

1/2

tab

35
kg

ADULT
1 tab

Reduce doses according to clinical response.


In case of persistant oedema: 80 to 150 mg once or in 2 divided doses, then reduce dosage.

Duration: according to clinical response

Do not administer for other types of oedema, especially those due to kwashiorkor.
May cause:
hypokalaemia (especially in case of cirrhosis), poor nutritional status, congestive heart
failure (furosemide enhances toxicity of digoxin);
dehydration and orthostatic hypotension.
Pregnancy: avoid, do not use for hypertension in pregnancy
Breast-feeding: avoid (excreted in milk and may reduce milk production)

Contra-indications, adverse effects, precautions

Give in the morning.


A lot of fruit should be eaten during treatment (dates, bananas, mangos, oranges, etc.) in
order to supply additional potassium. Use potassium tablets as well if available.
Storage: no special temperature requirements

Remarks

71

GLIBENCLAMIDE
(Daonil, Euglucon)

Prescription under medical supervision

Sulphonylurea hypoglycaemic which stimulates secretion of pancreatic insulin

Therapeutic action

Adult-onset diabetes, insulin-independent and not controlled by well followed diet


Measurement of blood glucose levels is essential in establishing diagnosis and control of
the disease process.

Indications

2.5 mg and 5 mg tablets


Also comes in 1.25 mg tablet.

Presentation

Adult: initially, 2.5 to 5 mg once daily in the morning


Adjust dosage until diabetic control is obtained; maximum dose: 15 mg/day.
Adjust dosage gradually and very cautiously for elderly patients.

Dosage

Duration: according to clinical response and laboratory tests

Do not administer if:


insulin-dependent diabetes, juvenile diabetes mellitus;
renal, hepatic or thyroid function impairment, allergy to sulphonamides.
May cause:
hypoglycaemia due to excessive doses, especially in elderly patients; insufficient intake
of sugar; hepatic or renal failure. Treat mild hypoglycaemia with intake of oral sugar and
IV injection of hypertonic glucose solution if severe; adjust dosage;
allergic reactions.
Avoid combination with: co-trimoxazole, aspirin and other anti-inflammatory drugs, betablockers (risk of hypoglycaemia), barbiturates, glucocorticoids, oral contraceptives
(antagonise hypoglycaemic effect), etc.
Avoid combination with alcohol: antabuse reaction.
Pregnancy: CONTRA-INDICATED during the third trimester
Breast-feeding: CONTRA-INDICATED

Contra-indications, adverse effects, precautions

Use only when diabetes cannot be controlled with diet alone, and monitor blood-glucose
levels regularly.
Use of oral antidiabetics does not mean dietetic measures should be cancelled.
Insulin may be required in patients having surgery.
Chlorpropamide (Diabinese) is a long-acting sulphonylurea hypoglycaemic used at doses
of 125 to 250 mg once daily. Risk of hypoglycaemia is higher than with other antidiabetics.
Storage: below 30C

Remarks

72

GLYCERYL TRINITRATE = NITROGLYCERIN = TRINITRIN


Prescription under medical supervision
Vasodilator, antianginal

Therapeutic action

Short-term prophylaxis and treatment of angina

Indications

0.5 mg sublingual tablet

Presentation

Short-term prophylaxis of acute angina (sublingually)


Adult: 0.5 to 1 mg taken 5 to 10 minutes before a precipitating event (exercise, stress, etc.)

Dosage

Treatment of acute angina (sublingually)


Adult: 0.5 to 1 mg, to be repeated 1 to 3 times at 3-4 minute intervals
Maximum dose: 3 mg/day

Duration: according to clinical response

Do not administer to patients with obstructive cardiomyopathy, hypotension, shock.


May cause: orthostatic hypotension (especially in elderly patients), headache, nausea,
flushing of the face, haemolysis in patients with G6PD deficiency, severe hypotension with
risk of circulatory collapse in the event of overdose.
Use the lowest effective dose in patients taking another nitrate derivative, a vasodilator or
an antihypertensive drug and in elderly patients.
Combination with antihypertensive drugs, diuretics, vasodilators and alcohol enhances
hypotensive effects.
Do not combine with sildenafil (risk of acute coronary syndrome).
Pregnancy: not recommended (safety is not established)
Breast-feeding: not recommended (safety is not established)

Contra-indications, adverse effects, precautions

Tablet must be crunched first, then slowly dissolved under the tongue.
Antianginal effect appears within less than 5 minutes and persists for less than 1 hour.
Sustained-release formulations (Sustac, etc.) are used for the long-term management of
angina and the treatment of congestive heart failure.

Storage: below 25C, preferably in airtight glass container.

Remarks

73

GRISEOFULVIN
(Fulcine, Grisovin)

Prescription under medical supervision

Antifungal

Therapeutic action
Dermatophyte infections of the scalp (scalp ringworm)
Dermatophyte infections of the skin and folds, in the event of extended lesions or if the
topical treatment has failed

Indications

125 mg and 500 mg tablets


Also comes in 250 mg tablet and 125 mg/5 ml oral solution.

Presentation

Child 1 to 12 years: 10 to 20 mg/kg once daily or in 2 divided doses, during meals (max.
500 mg/day)
Child over 12 years and adult: 500 mg to 1 g once daily or in 2 divided doses, during meals
(max. 1 g/day)

Dosage

AGE

WEIGHT

1
year

125 mg/5 ml oral solution


125 mg tablet

500 mg tablet

2
years

10
kg

5 ml

1 tab

1/4

tab

13
kg

7
years

10 ml
2 tab

1/2

tab

24
kg

12
years

4 tab

1 tab

35
kg

ADULT

4 to 8 tab
1 to 2 tab

Scalp: 6 weeks on average


Skin and folds: 4 to 6 weeks

Duration

Do not administer to patients with hepatic impairment, lupus erythematous, porphyria


(may trigger attacks of acute porphyria).
May cause: gastrointestinal disturbances, headache, skin reactions (eruption, urticaria, etc.);
photosensitivity (protect exposed skin from sun exposure).
Monitor patients taking warfarin (anticoagulant effect decreased).
Avoid alcohol during treatment (antabuse effect).
Pregnancy and breast-feeding: CONTRA-INDICATED. Apply a topical treatment (miconazole 2%
cream or Whitfield ointment) in order to limit the lesions until it is possible to use griseofulvin.

Contra-indications, adverse effects, precautions

For young children, if the oral solution is not available, crush the tablet and mix it with a
liquid.
Storage: no special temperature requirements

Remarks

74

HALOFANTRINE
(Halfan)

Prescription under medical supervision

The drug must only be used in hospital settings. Its potential


cardiotoxicity is unpredictable, even with the aid of an ECG.

Therapeutic action
Antimalarial

Indications

Treatment of uncomplicated falciparum malaria, when no other effective antimalarial is


available, never as first-line treatment

Presentation

250 mg tablet
100 mg/5 ml oral suspension

Dosage

Child over 1 year or over 10 kg: 24 mg/kg in 3 divided doses every 6 hours, between meals
Adult: 1500 mg in 3 divided doses every 6 hours, between meals
Do not exceed indicated doses.

Duration: one day

Contra-indications, adverse effects, precautions

Do not administer to patients with hypersensitivity to halofantrine, cardiopathy, bradycardia,


arrhythmia, family history of unexplained death or of prolongation of the QT interval,
personal history of congenital or acquired prolongation of the QT interval or of unexplained
syncope, severe electrolytic disorders, vitamin B1 deficiency.
Do not administer to children under 1 year.
Do not administer to patients who have received mefloquine in the previous 3 weeks
(cardiotoxicity is more marked).
May cause: prolongation of the QT interval, torsades de pointes and other serious ventricular
arrhythmias, sometimes fatal; diarrhoea, abdominal pain, nausea, vomiting, skin rash.
ECG monitoring is essential before giving treatment.
Do not combine with drugs inducing torsades de pointes: anti-arrhythmics (quinidine,
amiodarone, sotalol, etc.), neuroleptics (haloperidol, chlorpromazine), erythromycin IV,
pentamidine; drugs inducing hypokalaemia (diuretics, glucocorticoids, amphotericin B,
etc.), azole antifungals, most of protease inhibitors.
Pregnancy: CONTRA-INDICATED
Breast-feeding: CONTRA-INDICATED

Remarks

Halofantrine should not be used for prophylaxis.


Halofantrine is not included in the WHO list of essential medicines.
Storage: below 30C
Once opened, oral suspension keeps for 15 days.

75

HALOPERIDOL
(Haldol, Serenace)

Prescription under medical supervision

Antipsychotic (neuroleptic)

Therapeutic action

Acute or chronic psychosis


Severe anxiety not controlled by benzodiazepines

Indications

5 mg tablet
2 mg/ml oral solution (1 ml = 20 drops)
Also comes in 0.5 and 2 mg tablets.

Presentation

Acute or chronic psychosis


Adult: 2 to 10 mg/day in 2 divided doses. If necessary, these doses may be gradually increased
up to 20 mg/day according to clinical response. Once the patient is stable, the maintenance
dose is administered once daily in the evening.
Severe anxiety not controlled by benzodiazepines
Adult: 1 mg/day (10 drops/day) in 2 divided doses
Whatever the indication, reduce the dose by half in elderly patients.
Use the lowest effective dose, especially in the event of prolonged treatment.

Dosage

Acute psychosis: minimum 3 months; chronic psychosis: minimum one year. The treatment
should be discontinued gradually (over 4 weeks). If signs of relapse occur, increase the
dose.
Severe anxiety: maximum 4 weeks.

Duration

Do not administer to patients with cardiac disorders (cardiac failure, recent myocardial
infarction, conduction disorders, bradycardia, etc.); to elderly patients with dementia (e.g.
Alzheimer's disease).
Administer with caution and carefully monitor use in patients > 60 years and patients with
hypokalaemia, hyperthyroidism, renal or hepatic impairment, Parkinson's disease.
May cause: drowsiness (caution when driving/operating machinery), extrapyramidal
syndrome, early and tardive dyskinesia, sexual dysfunction, QT-prolongation, ventricular
arrhythmia, orthostatic hypotension; neuroleptic malignant syndrome (unexplained hyperthermia with neuromuscular disorders), rare but requiring immediate treatment discontinuation.
In the event of extrapyramidal symptoms, combine with biperiden.
Avoid combination with: carbamazepine, rifampicin, fluoxetine, lithium, drugs that
prolong the QT interval (amiodarone, chloroquine, erythromycin, fluconazole, mefloquine,
pentamidine, quinine).
Avoid alcohol during treatment.
Pregnancy: re-evaluate whether the treatment is still necessary; if it is continued, monitor the newborn
infant for reversible extrapyramidal effects (tremors) if the mother was under high dose treatment in
the 3rd trimester.
Breast-feeding: avoid; if absolutely necessary, administer less than 5 mg/day.

Contra-indications, adverse effects, precautions

Haloperidol produces less orthostatic hypotension than chlorpromazine and has little
anticholinergic effects. It is less sedative than chlorpromazine but produces more extrapyramidal symptoms.
Storage: no special temperature requirements

Remarks

76

HYDROCHLOROTHIAZIDE
(Esidrex, HydroSaluric)

Prescription under medical supervision

Diuretic

Therapeutic action
Moderate or severe hypertension
Oedema caused by renal, hepatic or congestive heart failure

Indications

50 mg tablet
Also comes in 25 mg tablet.

Presentation

Hypertension
Adult: 25 to 50 mg/day in 2 divided doses

Dosage

Oedema
Child: 1 mg/kg/day in 2 divided doses
Adult: 50 to 100 mg in the morning, on alternate days

AGE

WEIGHT

Hypertension
50 mg tablet

2
months
4
kg

1
year
8
kg

Oedema
50 mg tablet

5
years
15
kg

1/4

15
years
35
kg

tab x 2

ADULT

1/4 to

1 tab
x2

1 to 2 tab
every 2 days

Duration: according to clinical response


Do not administer if severe renal failure, allergy to sulphonamides; for other types of oedema,
especially those due to kwashiorkor.
May cause: dehydration, hypotension, hypokalaemia, photosensitivity, hyperglycaemia.
Pregnancy: CONTRA-INDICATED
Breast-feeding: CONTRA-INDICATED

Contra-indications, adverse effects, precautions

Often used in combination with an antihypertensive drug.


A lot of fruit should be eaten during treatment (dates, bananas, mangos, oranges, etc.), in
order to supply additional potassium. Use potassium tablets as well if available.
Storage: no special temperature requirements

Remarks

78

HYOSCINE BUTYLBROMIDE = BUTYLSCOPOLAMINE


(Buscopan...)

Prescription under medical supervision

Antispasmodic

Therapeutic action

Spasms of the gastrointestinal tract and genitourinary tract

Indications

10 mg tablet

Presentation

Child from 6 to 12 years: 10 mg to be repeated up to 3 times per day if necessary


Adult: 10 to 20 mg to be repeated up to 3 or 4 times per day if necessary

Dosage

Duration: according to clinical response; no prolonged treatment.

Do not administer tablets to children under 6 years (use injectable hyoscine butylbromide).
Do not administer to patients with urethro-prostatic disorders, cardiac disorders, glaucoma.
Do not administer to children with high fever.
May cause: urinary retention, dryness of the mouth, constipation, blurred vision, tachycardia.
Administer with caution and under close supervision to patients taking other anticholinergic drugs (antidepressants, neuroleptics, H-1 antihistamines, antiparkinsonians, etc.).
Pregnancy: no contra-indication; NO PROLONGED TREATMENT
Breast-feeding: no contra-indication; NO PROLONGED TREATMENT

Contra-indications, adverse effects, precautions

Other antispasmodics are used in certain countries:


atropine (child: 0.01 mg/kg every 4 to 6 hours, without exceeding 0.4 mg/day; adult: 0.4
to 0.6 mg every 4 to 6 hours),
propantheline (adult: 45 to 120 mg/day in 3 divided doses).
Antispasmodic drugs are not included in the WHO list of essential medicines.
Storage: below 30C

Remarks

79

IBUPROFEN
(Advil, Brufen, Nureflex)

Prescription under medical supervision

Analgesic, antipyretic, non-steroidal anti-inflammatory (NSAID)

Therapeutic action

Mild to moderate pain, fever, rheumatic diseases

Indications

200 mg and 400 mg enteric-coated tablets


100 mg/5 ml oral suspension, with pipette graduated per kg of body weight (each kg
graduation corresponds to 10 mg ibuprofen)

Presentation

Pain, fever
Child over 3 months: 30 mg/kg/day in 3 divided doses (= one pipette filled up to the
graduation corresponding to the child's weight, 3 times per day)
Adult: 1200 to 1800 mg/day in 3 to 4 divided doses
In post-operative period, ibuprofen should be given on a regular basis, every 8 hours,
rather than as needed.

Dosage

AGE

WEIGHT

100 mg/5 ml oral susp.


200 mg tablet
400 mg tablet

3
months

Do not
administer

5
kg

6
years

Use the graduated pipette


for oral solution

Rheumatoid arthritis
Child: up to 40 mg/kg/day maximum
Adult: up to 3200 mg/day maximum

20
kg

15
years

35
kg

ADULT

1 to 2 tab x 3 2 tab x 3 or 4

1 tab x 3 or 4

Duration: according to clinical response; post-operative pain: 8 days maximum

Do not administer to children under 3 months, patients with allergy to NSAID, peptic ulcer,
coagulation defects, haemorrhage, surgery with risk of major blood loss, severe renal or
hepatic impairment, severe heart failure, severe malnutrition, uncorrected dehydration or
hypovolaemia, severe infection.
May cause: allergic reactions, epigastric pain, peptic ulcer, haemorrhage, renal impairment.
Administer with caution to elderly or asthmatic patients.
Do not combine with: methotrexate, anticoagulants and other NSAIDs.
Monitor combination with diuretics and angiotensin-converting enzyme inhibitors (drink
plenty of fluids to avoid renal failure).
Pregnancy: not recommended during the first 5 months. CONTRA-INDICATED from the beginning of
the 6th month (use paracetamol)
Breast-feeding: no contra-indication (short term treatment)

Contra-indications, adverse effects, precautions

Take with meals.


Clean the graduated pipette after use. Shake the bottle before use.
If ibuprofen alone does not provide pain relief, combine with paracetamol and/or an
opioid analgesic.
Storage: below 30C

Once opened, oral suspension must be stored between 8C and 15C.

Remarks

80

INDINAVIR = IDV
(Crixivan)

Prescription under medical supervision

Antiretroviral, HIV-1 and HIV-2 protease inhibitor

Therapeutic action

HIV-1 or HIV-2 infection, in combination with two nucleoside reverse transcriptase inhibitors and usually with a low-dose of ritonavir as booster

Indications

200 mg, 333 mg and 400 mg capsules

Presentation

Administration of indinavir without ritonavir


Child from 4 years: 1500 mg/m2/day in 3 divided doses, without exceeding 800 mg per
dose
Adult: 2400 mg/day in 3 divided doses

Posologie

Weight

200 mg capsule

400 mg capsule

20 to 24 kg

2 cap x 3

1 cap x 3

10 to 14 kg
15 to 19 kg
25 to 29 kg
30 to 49 kg
50 kg

1 cap x 3
2 cap x 3
2 cap x 3
3 cap x 3
4 cap x 3

1 cap x 3
1 cap x 3

2 cap x 3

Concomitant administration of indinavir + ritonavir


Adult: 1600 mg/day of indinavir + 200 mg/day of ritonavir in 2 divided doses
The duration of treatment depends on the efficacy and tolerance of indinavir.

Duration

May cause: gastrointestinal disturbances, rash, dry skin, myalgia, taste disturbances, headache, dizziness, urinary lithiasis (more frequent in children or when combined with ritonavir), hepatic disorders (raised transaminases or bilirubin), haematological disorders
(neutropenia), metabolic disorders (lipodystrophy, hyperlipidaemia, diabetes mellitus with
glucose intolerance and/or insulin resistance).
Do not combine with rifampicin, phenobarbital and carbamazepine (reduced indinavir
plasma concentration).
When used concomitantly with oestrogen-progestogen oral contraceptives: increased risk
of thromboembolism.
Reduce dosage in patients with hepatic impairment (1800 mg/day).
Administer with caution to patients with haemophilia (risk of haemorrhage).
When patients receive indinavir and didanosine, administer first indinavir (as it requires
acid for absorption), wait one hour, then administer didanosine.
Pregnancy: no contra-indication
Breast-feeding: not recommended

Contra-indications, adverse effects, precautions

Take with plenty of water (200 ml). Drink at least 1.5 to 2 litres of water/day.
Indinavir administered on its own (without ritonavir) must be taken 1 hour before or
2 hours after a meal.
Storage:

Remarks

81

IODIZED OIL
(Lipiodol)

Iodine supplementation

Therapeutic action

Prevention and treatment of severe iodine deficiency

Indications

200 mg capsule

Presentation

Child under 1 year: 200 mg (1 capsule) once a year


Child from 1 to 5 years: 400 mg (2 capsules) once a year
Child from 6 to 15 years: 600 mg (3 capsules) once a year
Pregnant woman or women of childbearing age: 400 mg (2 capsules) once a year

Do not administer to patients with allergy to iodine or hyperthyroidism.


Do not administer to patients over 45 years.
May cause: allergic reactions, dysthyroidism.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Dosage and duration

Contra-indications, adverse effects, precautions

Also comes in 10 ml ampoule containing 480 mg/ml (Lipiodol Ultra-Fluide) to be administered orally or by IM injection using a glass syringe:
children under 1 year: 0.5 ml
children from 1 to 15 years, pregnant women or women of childbearing age: 1 ml
Storage: below 30C

Remarques

82

ISONIAZID = H
Prescription under medical supervision
First line antituberculous antibacterial (bactericidal activity)

Therapeutic action

Treatment of tuberculosis, in combination with other antituberculous antibacterials


Prophylaxis of tuberculosis

Indications

100 mg and 300 mg tablets


50 mg/5 ml oral solution

Presentation

Child under 30 kg: 10 mg/kg (7 to 15 mg/kg/day) once daily, on an empty stomach


Child over 30 kg and adult: 5 mg/kg (4 to 6 mg/kg/day) once daily, on an empty stomach
Maximum dose: 300 mg/day

Dosage

According to protocol

Duration

Do not administer to patients with severe hepatic impairment.


May cause:
peripheral neuropathy, especially in malnourished, alcoholic, diabetic, HIV-infected
patients; pregnant and breast-feeding women; patients with renal impairment or chronic
hepatic disease and patients receiving high doses of isoniazid.
hepatic disorders (jaundice), especially in alcoholic patients, patients receiving rifampicin,
patients > 35 years.
hypersensitivity reactions, psychotic reactions.
If signs of hepatotoxicity (e.g. jaundice) develop, isoniazid should be discontinued until
symptoms resolve.
Administer with caution and closely monitor patients taking phenytoin, carbamazepine,
benzodiazepines (risk of toxicity), warfarin (risk of bleeding), cycloserine (increased risk of
peripheral neuropathy).
Administer pyridoxine (vitamin B6) in patients at risk of peripheral neuropathy (child:
5 mg/day; adult: 10 mg/day).
Pregnancy: no contra-indication
Breast-feeding: no contra-indication; supplement the infant with pyridoxine (5 mg/day).

Contra-indications, adverse effects, precautions

Isoniazid is included in the WHO Group 1 antituberculous agents. However, when used at
high doses (child: 20 mg/kg/day; adult: 16 to 20 mg/kg/day), it is included in the Group 5.
Prophylactic treatment should be considered only after excluding active tuberculosis.
For patients on first-line antituberculous treatment, isoniazid is given as part of a fixed dose
combination (isoniazid+rifampicin+pyrazinamide+ethambutol or isoniazid+rifampicin+
pyrazinamide or isoniazid+rifampicin).

Storage: below 30C

Remarks

83

ISOSORBIDE DINITRATE
(Isordil, Risordan, Sorbitrate)

Prescription under medical supervision

Vasodilator, antianginal

Therapeutic action

Prophylaxis and treatment of acute angina


Adjunctive therapy in left congestive heart failure

Indications

5 mg tablet

Presentation

Short-term prophylaxis of acute angina (sublingually)


Adult: 5 to 10 mg taken 10 minutes before a precipitating event (exercise, stress, etc.)

Dosage

Long-term prophylaxis of angina and treatment of heart failure (orally)


Adult: 30 to 120 mg/day in 2 to 3 divided doses. Gradually increase the dose until effective.
Do not stop treatment abruptly.
Treatment of acute angina (sublingually)
Adult: 5 to 10 mg, to be repeated after 10 minutes if necessary

Duration: according to clinical response

Do not administer to patients with obstructive cardiomyopathy, hypotension, shock.


May cause: orthostatic hypotension (especially in elderly patients), headache, nausea,
flushing of the face, haemolysis in patients with G6PD deficiency, severe hypotension with
risk of circulatory collapse in the event of overdose.
Use the lowest effective dose in patients taking another nitrate derivative, a vasodilator or
an antihypertensive drug and in elderly patients.
Combination with antihypertensive drugs, diuretics, vasodilators and alcohol enhances
hypotensive effects.
Do not combine with sildenafil (risk of acute coronary syndrome).
Pregnancy: not recommended (safety is not established)
Breast-feeding: not recommended (safety is not established)

Contra-indications, adverse effects, precautions

Sublingual tablet must be crunched first, then slowly dissolved under the tongue. Oral
tablet must be swallowed whole.
By sublingual route, antianginal effect appears within less than 10 minutes and persists for
1 to 2 hours.
Sustained-release formulations are used for the long-term management of angina and the
treatment of congestive heart failure. The time interval between each administration
depends on the preparations.

Storage: below 25C

Remarks

84

ITRACONAZOLE
(Sporanox)

Prescription under medical supervision

Antifungal

Therapeutic action
Histoplasmosis and penicilliosis: treatment and secondary prophylaxis
Dermatophytosis of the scalp (Tinea capitis)

Indications

100 mg capsule
Also comes in 50 mg/5 ml oral solution.

Presentation

Histoplasmosis (moderate symptoms)


Child: 5 mg/kg once daily for 6 to 12 weeks
Adult: 600 mg/day in 3 divided doses for 3 days then 200 mg once daily or 400 mg/day in
2 divided doses for 6 to 12 weeks

Dosage and duration

Histoplasmosis (severe symptoms, disseminated form)


Same treatment for 12 weeks, preceded by one to 2 weeks of treatment with amphotericin B
Penicilliosis (moderate symptoms)
Adult: 400 mg/day in 2 divided doses for 8 weeks

Penicilliosis (severe symptoms)


Same treatment for 10 weeks, preceded by 2 weeks of treatment with amphotericin B
Secondary prophylaxis of histoplasmosis and penicilliosis
Adult: 200 mg once daily as long as required
Dermatophytosis of the scalp
Child: 3 to 5 mg/kg once daily for 4 weeks
Adult: 200 mg once daily for 2 to 4 weeks

Administer with caution and monitor use in patients > 60 years or with hepatic or renal
impairment or congestive heart failure.
May cause: gastrointestinal disturbances, headache, skin reactions sometimes severe,
anaphylactic reaction, hepatic disorders sometimes severe, paraesthesia, oedema, cardiac
failure. Stop treatment in the event of anaphylactic reaction, hepatic disorders or severe
skin reaction.
In case of prolonged treatment, monitor liver function.
Do not combine with quinidine (risk of arrhythmia).
Avoid or monitor combination with amiodarone, calcium-channel blockers, benzo diazepines, certain antiretrovirals (e.g. indinavir, ritonavir, saquinavir), corticosteroids
(dexamethasone, prednisolone), warfarin, carbamazepine, digoxin: increased blood
concentration of these drugs.
Efficacy of itraconazole may be reduced when combined with: rifampicin, rifabutin,
isoniazid, efavirenz, phenytoin, phenobarbital.
Do not administer simultaneously with aluminium or magnesium hydroxide: administer
2 hours apart.
Pregnancy and breast-feeding: avoid; for histoplasmosis, amphotericin B alone for 4 to 6 weeks is an
alternative in pregnant women. Do not administer in the event of dermatophytosis of the scalp
(apply a topical treatment until it is possible to use itraconazole).

Contra-indications, adverse effects, precautions

Do not open the capsules; take with meals.


Storage: below 30C

Remarks

85

IVERMECTIN
(Mectizan, Stromectol)

Prescription under medical supervision

Anthelminthic, scabicide

Therapeutic action

Onchocerciasis
Scabies

Indications

3 mg and 6 mg tablets

Presentation

Onchocerciasis
Child over 15 kg and adult: 150 g/kg as a single dose. A 2nd dose should be administered
after 3 months if clinical signs persist. Repeat the treatment every 6 or 12 months to
maintain the parasite load below the threshold at which clinical signs appear.

Dosage and duration

HEIGHT

WEIGHT

3 mg tablet
6 mg tablet

90 cm
15 kg

Do not
administer

120 cm

1 tab

1/2

25 kg

tab

160 cm

140 cm

2 tab

1 tab

45 kg

3 tab

11/2 tab

65 kg

4 tab

2 tab

Ordinary scabies
Child over 15 kg and adult: 200 g/kg as a single dose. A single dose may be sufficient; a
2nd dose one week later reduces the risk of treatment failure.
Crusted scabies
Child over 15 kg and adult: 2 doses of 200 g/kg one week apart, in combination with a
topical keratolytic and topical scabicide; additional doses may be necessary.

May cause:
increased itching;
moderate reactions in patients with onchocerciasis: ocular irritation, headache, arthralgia,
myalgia, lymphadenopathy, fever, oedema;
severe reactions in patients co-infected with Loa loa: marked functional impairment if Loa loa
microfilaraemia > 8,000 mf/ml; encephalopathy if Loa loa microfilaraemia > 30,000 mf/ml.
Administer with caution in regions where loiasis is endemic:
For symptomatic onchocerciasis:
Evaluate the severity of Loa loa microfilaraemia and manage accordingly: either treat as
an out-patient under supervision, or hospitalise, or choose an alternative treatment
(doxycycline).
If it is not possible to perform a thick film examination: ivermectin may be administered
if the patient has no history of loiasis (migration of an adult worm under the conjunctiva
or transient Calabar swellings), nor history of severe adverse reactions following a
previous treatment with ivermectin. In other cases, it is wiser either to treat under
supervision, or to choose an alternative treatment (doxycycline), or decide not to treat,
according to the severity of the onchocerciasis and the previous history.
For ordinary scabies: review the patients history and if in doubt, topical scabicidal
treatment is preferred.
Pregnancy: avoid (safety is not established)
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Take tablets on an empty stomach.


Ivermectin is also used for the treatment of strongyloidiasis (200 g/kg as a single dose)
and cutaneous larva migrans (200 g/kg daily for 1 to 2 days).
Storage: below 30C

Remarks

86

LABETALOL
Prescription under medical supervision
Therapeutic action

Non cardioselective beta-blocker

Indications

Hypertension in pregnancy

Presentation

100 mg and 200 mg tablets

Dosage

200 mg/day in 2 divided doses. Increase if necessary in 100 to 200 mg increments until an
effective dose is reached, usually 400 to 800 mg/day (max. 2400 mg/day). If higher doses
are required, give in 3 divided doses.

Duration

According to clinical response. Do not stop treatment abruptly, decrease doses gradually.

Contra-indications, adverse effects, precautions

Do not administer to patients with asthma, chronic obstructive bronchopneumonia, heart


failure, severe hypotension, bradycardia < 50/minute, atrio-ventricular heart blocks,
Raynaud's syndrome, hepatic impairment.
May cause: bradycardia, hypotension, heart failure, bronchospasm, hypoglycaemia, gastrointestinal disturbances, dizziness, headache, weakness, urinary retention.
Administer with caution to patients with diabetes (risk of hypoglycaemia).
Reduce dosage in patients with renal impairment.
In the event of anaphylactic shock, risk of resistance to epinephrine.
Avoid or monitor combination with: mefloquine, digoxin, amiodarone, diltiazem, verapamil
(risk of bradycardia); tricyclic antidepressants, neuroleptics, other anti-hypertensive drugs
(risk of hypotension).
Do not administer simultaneously with antacids (aluminium or magnesium hydroxide,
etc.). Administer 2 hours apart.
Monitor the newborn: risk of hypoglycaemia, bradycardia, respiratory distress occurring
most often during the first 24 hours and until 72 hours after the birth.
Breast-feeding: no contra-indication

Remarks

Storage: below 25C

86

LACTULOSE
(Duphalac)

1
Osmotic laxative

Therapeutic action

Prevention of constipation in patients taking opioid analgesics (e.g. codeine, morphine)

Indications

10 g/15 ml oral solution

Presentation

Child under 1 year: 5 ml/day (1 tsp/day)


Child from 1 to 6 years: 5 to 10 ml/day (1 to 2 tsp/day)
Child from 7 to 14 years: 10 to 15 ml/day (2 tsp/day or 1 ssp/day)
Child over 14 years and adult: 15 to 45 ml/day (1 to 3 ssp/day)

Dosage and duration

Start lactulose when analgesic treatment continues more than 48 hours. Lactulose must be
taken daily, until the end of the opioid treatment. Regular follow up (frequency/consistency
of stools) is essential in order to adjust dosage correctly.

Do not administer to patients with Crohns disease, ulcerative colitis, intestinal obstruction,
undiagnosed abdominal pain.
May cause: abdominal discomfort, flatulence and diarrhoea.
In the event of diarrhoea, exclude a faecal impaction and intestinal obstruction; reduce the
dose.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

It may take up to 48 hours, or even longer, before the treatment is effective. Lactulose is not
indicated in acute constipation where a rapid result is needed.
If necessary, lactulose may be given in combination with a stimulant laxative (e.g. bisacodyl,
senna).
The oral solution may be taken undiluted, or diluted in water.
The treatment should be accompanied by dietary measures (fluids and fibre).
Storage: below 25C. Do not store in a refrigerator (cristallisation).

Remarks

87

LAMIVUDINE = 3TC
(Epivir, Lamivir)

Prescription under medical supervision

Antiretroviral, HIV-1 and HIV-2 nucleoside reverse transcriptase inhibitor

Therapeutic action

HIV-1 or HIV-2 infection, in combination with other antiretroviral drugs

Indications

150 mg and 300 mg tablets


50 mg/5 ml oral solution

Presentation

Child under 1 month: 4 mg/kg/day in 2 divided doses


Child from 1 month to 12 years: 8 mg/kg/day in 2 divided doses
Adult: 300 mg once daily or in 2 divided doses

Dosage

Weight

5 to 9 kg

10 to 14 kg
15 to 19 kg
20 to 24 kg
25 to 29 kg
30 kg

10 mg/ml
oral solution
2.5 ml x 2

150 mg tablet

300 mg tablet

5 ml x 2
7 ml x 2
9 ml x 2

11 ml x 2

1/2 tab
1/2 tab

x2
x2

2 tab
2 tab

1 tab
1 tab

The duration of treatment depends on the efficacy and tolerance of lamivudine.

Duration

Administer with caution to patients with history of hepatic disorders.


May cause: gastrointestinal disturbances (diarrhoea, nausea, vomiting, etc.) and possibly:
haematological disorders, especially when combined with zidovudine (neutropenia, anaemia, thrombocytopenia), myopathy, hepatic or pancreatic disorders.
Reduce dosage in patients with renal impairment.
Pregnancy: no contra-indication
Breast-feeding: not recommended

Contra-indications, adverse effects, precautions

For prophylactic treatment to reduce mother-to-child HIV transmission, check national


recommendations.
Also comes in fixed-dose combination tablets incorporating lamivudine-zidovudine
(Combivir), lamivudine-zidovudine-abacavir (Trizivir) and lamivudine-stavudinenevirapine (Triomune, Triviro).
Storage:
Tablets : below 30C
Oral solution : below 25C. Once opened, solution keeps for 30 days maximum.

Remarks

88

LEVODOPA/CARBIDOPA
(Sinemet)

Prescription under medical supervision

Antiparkinson drug

Therapeutic action

Parkinsons disease and extrapyramidal disorders except those induced by neuroleptics

Indications

100 mg levodopa + 10 mg carbidopa tablet


250 mg levodopa + 25 mg carbidopa tablet

Presentation

Adult:
Initial dose of levodopa: 50 to 125 mg once or twice daily immediately after meals.
Increase in increments of 50 to 125 mg every day or on alternate days, to individual
optimal dose.
Maintenance dose: 750 to 1500 mg/day in 3 to 4 divided doses, immediately after meals.
Reduce dosage in elderly patients.

Dosage

Duration: according to clinical response

Do not administer if severe psychosis, mental confusion, closed-angle glaucoma, recent


myocardial infarction, malignant melanoma.
May cause:
early in treatment, when dose is not adjusted : anorexia, vomiting, orthostatic hypotension,
cardiac arrhythmia, agitation, insomnia or drowsiness, depression;
frequent delayed adverse effects, signs of excessive dosage, mainly:
dyskinesia, tremor;
psychiatric disorders more frequent in elderly patients: confusion, hallucinations,
delirium, depression with or without suicidal tendencies;
later in treatment : fluctuation of the effect during the day (daily dosage may be divided
into smaller doses and taken more frequently); or reduction of the effect (progression of
the disease).
Administer with caution in psychiatric disorders, cardiac disease, gastro-duodenal ulcer.
Do not administer simultaneously with MAOIs, antidepressants, neuroleptics, reserpine.
Pregnancy: CONTRA-INDICATED
Breast-feeding: CONTRA-INDICATED

Contra-indications, adverse effects, precautions

Tablet must be swallowed whole. Do not chew or dissolve.


Storage: below 30C

Remarks

89

Revised October 2014

LEVONORGESTREL
Prescription under medical supervision

Therapeutic action

Hormonal contraceptive, progestogen

Indications

Oral contraception

Presentation

30 micrograms (0.03 mg) tablet, 28-day pack or 35-day pack

Dosage

1 tablet daily at the same time, continuously, including during menstruation


Start the first day of menstruation or immediately after abortion or as of the 21st day after
childbirth if the woman does not breastfeed.
It is also possible to start at any moment of the cycle (if the woman is not pregnant). In this
case, contraception will be effective as of the 3rd tablet. It is essential to use condoms during
the first 2 days.

Duration

If there are no adverse effects, as long as contraception is desired.

Contra-indications, adverse effects, precautions

Do not administer to women with breast cancer, severe or recent liver disease, unexplained
vaginal bleeding, current thromboembolic disorders.
May cause: amenorrhoea, menstrual disturbances, nausea, weight gain, breast tenderness,
mood changes, acne, headache.
Hepatic enzyme inducers (rifampicin, rifabutin, nevirapine, nelfinavir, ritonavir, phenobarbital,
phenytoin, carbamazepine, griseofulvin, etc.) reduce the contraceptive efficacy. Use copper
intrauterine device or condoms or injectable medroxyprogesterone.
Pregnancy: CONTRA-INDICATED
Breast-feeding: it is recommended to wait 6 weeks after childbirth before starting levonorgestrel in
breastfeeding women. However, if it is the only contraceptive method available or acceptable, it can
be started 3 weeks after childbirth.

Remarks

Levonorgestrel is a possible alternative when estroprogestogens are contra-indicated or


poorly tolerated. However, it has a lesser contraceptive effect than estroprogestogens and
requires taking tablets at a precise time (no more than 3 hours late).
If a woman misses a tablet, she should take it as soon as possible and continue treatment
as normal. If she misses by over 3 hours, contraceptive protection will be lessened. It is
therefore recommended to use an additional contraceptive method: condoms for 7 days
and, if she has had sexual intercourse within 5 days before forgetting the tablet, emergency
contraception.
Storage: below 25C

91

Revised September 2014

LEVONORGESTREL for emergency contraception

Therapeutic action

Hormonal contraceptive, progestogen

Indications

Prevention of pregnancy in the event of a lapse or absence of contraception

Presentation

1.5 mg tablet

Dosage and duration

One 1.5 mg tablet as a single dose, whatever the day of the cycle, as soon as possible after
unprotected intercourse and preferably within the first 72 hours as effectiveness decreases
with time. It is however recommended to administer the treatment up to 120 hours (5 days)
after unprotected intercourse.

Contra-indications, adverse effects, precautions

No contra-indication.
May cause: menstrual irregularities, vaginal bleeding, nausea, headache, dizziness.
Re-administer treatment if vomiting occurs within 3 hours of taking treatment.
Double the dose (3 mg as a single dose) in women taking prophylactic antiretroviral treatment
or enzyme-inducing drugs (rifampicin, rifabutin, griseofulvin, phenytoin, phenobarbital,
carbamazepine, certain antiretrovirals): contraceptive effectiveness may be reduced.
Pregnancy: in the event of treatment failure (i.e. pregnancy develops) or if used during an undiagnosed
pregnancy, there is no known harm for the foetus.
Breast-feeding: no contra-indication

Remarks

Emergency contraception is intended to prevent pregnancy; it cannot terminate an ongoing


pregnancy.
There is a risk of treatment failure. Carry out a pregnancy test if there is no menstruation:
within 5 to 7 days after the expected date, if the date is known;
or within 21 days following treatment.
Storage: below 25C

92

LOPERAMIDE
(Imodium)

Prescription under medical supervision

Opioid antidiarrhoeal

Therapeutic action

Symptomatic treatment of persistent diarrhoea in HIV patients, in combination with


rehydration

Indications

2 mg capsule or tablet
Also comes in 1 mg/5 ml oral solution.

Presentation

Child from 2 to 5 years: 3 mg/day in 3 divided doses


Child from 6 to 8 years: 4 mg/day in 2 divided doses
Child over 8 years: 6 mg/day in 3 divided doses

Dosage

Age

Weight

Oral solution
Capsule

0-2 years
< 13 kg

Do not
administer

2-5 years

6-8 years

> 8 years

2 tsp x 2

2 tsp x 3

13 - 20 kg

20 - 30 kg

1 caps x 2

1 tsp x 3

> 30 kg

1 caps x 3

Adult: 4 mg (2 capsules), then 2 mg (1 capsule) after each loose stool, without exceeding
16 mg/day (8 capsules/day)

Duration: according to clinical response

Do not exceed indicated doses.


Do not administer to children under 2 years.
Do not administer to patients with bloody diarrhoea, acute inflammatory bowel disease,
diarrhoea due to antibiotics.
May cause: constipation, allergic skin reactions, drowsiness, dizziness.
In the event of overdosage, treat with naloxone.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Rehydration is essential and must be adapted to the severity of diarrhoea.


Loperamide is not included in the WHO list of essential medicines.
Storage: below 30C

Remarks

92

LOPINAVIR/RITONAVIR = LPV/r
(Aluvia, Kaletra)

Prescription under medical supervision

Antiretrovirals, HIV-1 and HIV-2 protease inhibitors

Therapeutic action

HIV-1 or HIV-2 infection, in combination with other antiretroviral drugs

Indications

100 mg lopinavir/25 mg ritonavir film coated tablet


200 mg lopinavir/50 mg ritonavir film coated tablet
80 mg lopinavir/20 mg ritonavir per ml oral solution, containing 42% alcohol (v/v), with
a graduated syringe for oral administration

Presentation

Child from 14 days to 6 months: 32/8 mg/kg/day in 2 divided doses


Child over 6 months:
7 to 15 kg: 24/6 mg/kg/day in 2 divided doses
15 to 40 kg: 20/5 mg/kg/day in 2 divided doses
Adult: 800/200 mg/day in 2 divided doses

Dosage

Weight

< 4 kg

4 to 9 kg

10 to 13 kg
14 to 19 kg
20 to 25 kg
26 to 34 kg
> 35 kg

80/20 mg/ml
oral solution

100/25 mg
tablet

200/50 mg
tablet

2 ml x 2

1 ml x 2

1.5 ml x 2
2.5 ml x 2
3 ml x 2

2 tab x 2
3 tab x 2
4 tab x 2

Duration: depending on the efficacy and tolerance of LPV/r.

2 tab x 2

Do not administer to patients with severe hepatic impairment.


Do not administer oral solution to patients with renal or hepatic impairment.
May cause:
gastrointestinal disturbances (mainly diarrhoea), skin rash, pruritus;
hepatic disorders (raised transaminases), pancreatic disorders, metabolic disorders
(lipodystrophy, hyperlipidaemia, diabetes mellitus with glucose intolerance and/or
insulin resistance).
LPV/r may reduce the efficacy of oral contraceptives: use a non-hormonal contraception or
injectable medroxyprogesterone or make sure that the oral contraceptive used contains
50 g ethinylestradiol per tablet.
Do not combine with rifampicin (use rifabutin).
Administer with caution to patients with haemophilia (risk of haemorrhage) or renal or
hepatic impairment.
Pregnancy: oral solution is CONTRA-INDICATED

Contra-indications, adverse effects, precautions

Tablets may be taken with meals or on an empty stomach. The oral solution must be taken
with meals. If LPV/r oral solution is used concomitantly with didanosine, administer
didanosine 1 hour before or 2 hours after LPV/r, as it must be taken on an empty stomach.
The tablets must not be chewed or crushed.
Storage: tablets: below 30C; oral solution: between 2C and 8C. If refrigeration is not available,
oral solution kept below 25C may be stored for 6 weeks maximum.

Remarks

93

MEBENDAZOLE
(Pantelmin, Vermox, Wormin...)

Prescription under medical supervision

Therapeutic action

Anthelminthic

Indications

Ascariasis (Ascaris lumbricoides), trichuriasis (Trichuris trichiura), hookworm infections


(Ancylostoma duodenale, Necator americanus), enterobiasis (Enterobius vermicularis), trichinellosis
(Trichinella spp)

Presentation

100 mg and 500 mg tablets

Dosage and duration

Ascariasis, trichuriasis, hookworm infections


Child over 6 months and adult: 100 mg twice daily for 3 days
Child over 6 months but under 10 kg: 50 mg twice daily for 3 days
Enterobiasis
Child over 6 months and adult: 100 mg as a single dose
Child over 6 months but under 10 kg: 50 mg as a single dose
A second dose may be given after 2 to 4 weeks.

Trichinellosis
Child over 2 years: 5 mg/kg/day in 2 divided doses for 10 to 15 days
Adult: 400 mg/day in 2 divided doses for 10 to 15 days

Contra-indications, adverse effects, precautions

Do not administer to children under 6 months.


May cause: gastrointestinal disturbances, headache, dizziness.
Pregnancy: avoid during the first trimester
Breast-feeding: no contra-indication

Remarks

Albendazole is easier to use and is preferred in mixed infections as it has a broader


spectrum of activity.
Tablets are to be chewed or crushed: follow manufacturer's instructions.
Take tablets between meals.

Storage:

95

MEFLOQUINE = MQ
(Lariam)

Prescription under medical supervision

Antimalarial

Therapeutic action

Treatment of uncomplicated falciparum malaria, in combination with artesunate


Completion treatment following parenteral therapy for severe falciparum malaria, in
combination with artesunate
Prophylaxis of falciparum malaria for non-immune individuals

Indications

250 mg scored tablet

Presentation

Treatment of falciparum malaria (in combination with artesunate administered on D1, D2, D3)
Child from 3 months ( 5 kg) to 6 years: 25 mg base/kg as a single dose
Child 7 years and adult: 25 mg base/kg in 2 divided doses (15 mg base/kg on D1
followed by 10 mg base/kg on D2)

Dosage and duration

Age

3 to 11 months
1 to 6 years
7 to 13 years
14 years/adult

D1
1/2 tab
1 tab
2 tab
4 tab

250 mg tablet

D2

1 tab
2 tab

Prophylaxis of falciparum malaria


Child 3 months ( 5 kg): 5 mg base/kg once a week
Adult: 250 mg base once a week
Travellers should start prophylaxis 2 to 3 weeks before departure and continue throughout
the stay and for 4 weeks after return.

Do not administer to patients with neuropsychiatric disorders (or history of), seizures,
hypersensitivity to mefloquine or quinine; mefloquine treatment in the previous 4 weeks.
For completion treatment following parenteral therapy for severe malaria: do not administer
if the patient developed neurological signs during the acute phase.
For prophylaxis: do not administer to patients with severe hepatic impairment.
May cause:
gastrointestinal disturbances, dizziness, headache, sleeping disorders (effects usually
transitory when used for prophylaxis);
more rarely: neuropsychiatric reactions, heart rhythm disorders, hypo or hypertension,
skin allergies.
If the patient vomits less than 30 minutes after administration, repeat the full dose. If the
patient vomits within 30 to 60 minutes, re-administer a half the dose.
Do not combine with anti-epileptics (risk of seizures), coartemether, chloroquine,
halofantrine (risk of seizures, cardiac toxicity).
Do not administer simultaneously with quinine (risk of seizures, cardiac toxicity). If mefloquine is used after quinine IV, administer mefloquine 12 hours after the last dose of quinine.
Administer with caution to patients taking antiarrhythmics, beta-blockers, calcium-channel
blockers or digitalis (risk of heart rhythm disorders).
Pregnancy: no contra-indication during the 2nd and 3rd trimester. Safety in the first trimester has not been
definitely established. However, given the risks associated with malaria, the combination artesunatemefloquine may be used during the first trimester if it is the only effective treatment available.
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Storage: below 25C

Remarks

95

METAMIZOLE = DIPYRONE = NORAMIDOPYRINE


(Nolotil, Novalgin...)

Prescription under medical supervision

The use of this drug is not recommended:


it is potentially harmful;
it has been taken off the market in many countries;
it must never be prescribed as a first choice treatment.

Analgesic
Antipyretic

Therapeutic action

Severe pain
High fever

Indications

500 mg tablet

Presentation

Child over 5 years: 250 mg to 1 g/day in 3 divided doses


Adult: 500 mg to 3 g/day in 3 divided doses

Dosage

Duration: according to clinical response, 1 to 3 days

Do not administer in case of gastric ulcer.


Severe and fatal cases of agranulocytosis have been reported. Use only when usual antipyretics
and analgesics (acetylsalicylic acid and paracetamol) have been ineffective.
Pregnancy: avoid
Breast-feeding: avoid

Contra-indications, adverse effects, precautions

Metamizole is not included in the WHO list of essential medicines.


Storage: no special temperature requirements

Remarks

96

METHYLDOPA
(Aldomet)

Prescription under medical supervision

Centrally acting antihypertensive

Therapeutic action

Hypertension in pregnancy

Indications

250 mg tablet

Presentation

Initially 500 to 750 mg/day in 2 to 3 divided doses for 2 days, then increase gradually if
necessary by 250 mg every 2 to 3 days, until the optimal dose is reached, usually 1,5 g/day.
Do not exceed 3 g/day.

Dosage

According to clinical response. Do not stop treatment abruptly; reduce doses gradually.

Duration

Do not administer to patients with active liver disease, history of drug-related liver disease,
severe depression.
Administer with caution to patients with hepatic impairment, and reduce doses in patients
with renal impairment.
May cause:
orthostatic hypotension, drowsiness, headache, gastrointestinal disturbances, dry
mouth,
rarely: haematological, hepatic, psychical disorders; allergic reactions.
Stop treatment if haemolytic anaemia or jaundice appear during treatment.
In the event of unexplained fever during treatment, check blood count and transaminases
for possible hepatitis due to methyldopa.
Monitor combination with lithium (risk of lithium overdose), antidepressants (enhanced
hypotensive effect), CNS depressants (increased sedation).
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Storage: below 30C

Remarks

97

METOCLOPRAMIDE
(Primperan)

Prescription under medical supervision

Antiemetic (dopamine antagonist)

Therapeutic action

Symptomatic treatment of nausea and vomiting in adults

Indications

10 mg tablet

Presentation

Adult under 60 kg: 15 mg/day in 3 divided doses


Adult over 60 kg: 30 mg/day in 3 divided doses
The interval between each dose should be at least 6 hours (even in the event of vomiting).

Dosage

Duration: a few days

Do not administer to children < 18 years and to patients with gastrointestinal haemorrhage,
obstruction or perforation.
Reduce the dose by half in patients with severe renal impairment.
Administer with caution and monitor use in patients > 60 years and patients with epilepsy
or Parkinson's disease.
May cause: drowsiness (caution when driving/operating machinery), dizziness, confusion,
extrapyramidal symptoms, seizures (especially in epileptics), allergic reactions; neuroleptic
malignant syndrome (unexplained hyperthermia with neuromuscular disorders), exceptional
but requiring immediate treatment discontinuation.
Do not combine with levodopa (antagonism).
Avoid combination with CNS depressants (opioid analgesics, antipsychotics, sedatives,
antidepressants, antihistamines, etc.).
Avoid alcohol during treatment.
Pregnancy: no contraindication
Breast-feeding: no contraindication

Contra-indications, adverse effects, precautions

Storage: no special temperature requirements

Remarks

98

METRONIDAZOLE
Prescription under medical supervision
Therapeutic action

Antiprotozoal, antibacterial (group of nitroimidazoles)

Indications

Amoebiasis, giardiasis, trichomoniasis


Bacterial vaginitis, infections due to anaerobic bacteria (e.g. Clostridium sp, Bacteroides sp, etc.)

Presentation

250 mg and 500 mg tablets


200 mg/5 ml oral suspension

Dosage and duration

Amoebiasis
Child: 45 mg/kg/day in 3 divided doses
Adult: 500 to 800 mg 3 times daily
The treatment lasts 5 days in intestinal amoebiasis and 5 to 10 days in hepatic amoebiasis.
Giardiasis
Child: 30 mg/kg once daily for 3 days
Adult: 2 g once daily for 3 days

Trichomoniasis and bacterial vaginitis


Adult: 2 g as a single dose
In the event of trichomoniasis, also treat sexual partner.

Infections due to anaerobic bacteria


Child: 30 mg/kg/day in 3 divided doses
Adult: 500 mg 3 times daily
According to indication, metronidazole may be used in combination with other anti bacterials; treatment duration depends on indication.

Contra-indications, adverse effects, precautions

Do not administer to patients with hypersensitivity to metronidazole or another nitroimidazole (tinidazole, secnidazole, etc.).
May cause: gastrointestinal disturbances; rarely: allergic reactions, brownish urine,
headache, dizziness. Risk of antabuse reaction when combined with alcohol.
Administer with caution in patients taking oral anticoagulants (risk of haemorrhage),
lithium, phenytoin, ergometrine (increased plasma concentrations of these drugs).
Reduce total daily dose to 1/3 and give once daily to patients with severe hepatic
impairment.
Pregnancy: no contra-indication; divide into smaller doses, avoid prolonged use.
Breast-feeding: significantly excreted in milk (risk of gastrointestinal disturbances in breastfed
infants); divide into smaller doses, avoid prolonged use.

Remarks

Storage: below 25C


For the oral suspension: follow manufacturers instructions.

99

MICONAZOLE
(Tibozole)

Antifungal

Therapeutic action
Oropharyngeal candidiasis in immunodeficient patients

Indications

10 mg muco-adhesive buccal tablet

Presentation and route of administration


Child over 7 years and adult: one tablet once daily for 7 days; a 14-day treatment may be
required.

Dosage and duration

Moisten the tablet with the tongue. Place the tablet on the upper gingiva, above a lateral
incisor. Apply a slight pressure to the outside of the upper lip for a few seconds. The tablet
sticks to the gingiva and slowly releases miconazole for 8 to 12 hours.

May cause: nausea, altered taste.


Monitor patients taking warfarin (anticoagulant effect increased).
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Do not suck, chew or swallow tablets. The treatment being local, swallowing is not harmful
but is ineffective.
If the tablet unsticks within 6 hours, replace with another (only once over a 24-hour period).
If the tablet is accidentally swallowed, drink a glass of water.
Miconazole is not contra-indicated in young children but it is difficult to use correctly
muco-adhesive buccal tablets in children under 7 years.
Storage: below 25C
Tablets are packed in a blister containing 7 tablets. Leave tablets in blister until use. Once a tablet
is removed from the blister, it must be used immediately.

Remarks

100

Revised September 2014

MIFEPRISTONE = RU486
Prescription under medical supervision

Therapeutic action

Antiprogestogen

Indications

Termination of intra-uterine pregnancy, in combination with misoprostol


Induction of labour in the event of intrauterine foetal death, in combination with misoprostol

Presentation

200 mg tablet

Dosage and duration

Termination of pregnancy up to 12/14 weeks after the last menstrual period


200 mg as a single dose, followed by a dose of misoprostol 36 to 48 hours later
Induction of labour in the event of intrauterine foetal death
600 mg once daily for 2 days, followed by a dose of misoprostol the 3rd day

Contra-indications, adverse effects, precautions

Do not administer to patients with chronic adrenal failure or severe uncontrolled asthma.
May cause: gastrointestinal disturbances, vaginal bleeding, uterine contractions, headache.
Breast-feeding: no contra-indication for a single dose; to be avoided if multiple doses (induction of
labour in intrauterine foetal death)

Remarks

For labour induction in the event of intrauterine foetal death, mifepristone may sometimes
be sufficient to initiate labour but it is often necessary to administer misoprostol.
Do not use mifepristone in ectopic or molar pregnancy.

Storage: below 25C

102

Revised August 2014

MISOPROSTOL

Therapeutic action

Prescription under medical supervision

Cervical ripening agent, oxytocic drug (prostaglandin analogue)

Indications

Cervical dilation before aspiration or curettage


First trimester incomplete abortion
Termination of intra-uterine pregnancy, preferably in combination with mifepristone
Induction of labour when the cervix is not favourable, preferably in combination with
mifepristone in the case of intrauterine foetal death
Treatment of post-partum haemorrhage due to uterine atony, when injectable oxytocics are
not available or ineffective

Presentation

200 micrograms scored tablet

Dosage and duration

Cervical dilation before aspiration or curettage


400 micrograms as a single dose sublingually or vaginally, 3 hours before the procedure
First trimester incomplete abortion
400 micrograms as a single dose sublingually or 600 micrograms as a single dose orally
Termination of pregnancy up to 12-14 weeks after the last menstrual period
800 micrograms sublingually or vaginally then, if necessary, 400 micrograms every 3 hours,
until expulsion starts (max. 5 doses in total or 2400 micrograms)
Induction of labour
intrauterine foetal death: 200 micrograms (2nd trimester) or 100 micrograms (3rd trimester)
or 50 micrograms (9th month) vaginally, every 6 hours until labour starts (max. 3 doses
per 24 hours, to be repeated if necessary the following day)
viable pregnancy: 50 micrograms vaginally every 6 hours or 25 micrograms orally every
2 hours until labour starts (max. 150 micrograms)
Treatment of post-partum haemorrhage
800 micrograms as a single dose sublingually

Contra-indications, adverse effects, precautions

For induction of labour:


Do not administer in the event of previous caesarean section and grand multiparity if
the foetus is viable (risk of uterine rupture). If the foetus is dead or non-viable or viable
but a caesarean section cannot be performed, reduce each dose by half and do not exceed
3 doses in total.
Do not administer simultaneously with oxytocin. At least 6 hours must have elapsed
since the last administration of misoprostol before oxytocin can be given.
Regular monitoring of the intensity and frequency of contractions is mandatory after
administration of misoprostol.
If the foetus is viable, continuous foetal heart monitoring is mandatory for 30 minutes
after administration of each dose of misoprostol and once contractions are experienced
or detected.
May cause: dose-dependent diarrhoea, vomiting, uterine hypertony, headache, fever, chills,
foetal heart rhythm disorders, foetal distress.
Breast-feeding: no contra-indication

Remarks

To prepare an oral dose of 25 micrograms, dilute one 200 micrograms tablet into 200 ml of
water. Take 25 ml of the solution (1 microgram/ml). Shake the bottle before use.
For termination of pregnancy and induction of labour after intrauterine foetal death, it is
preferable to administer mifepristone first to improve the efficacy of misoprostol and
reduce the number of dose required.
Do not use misoprostol in ectopic or molar pregnancy.
Storage: below 25 C

103

MORPHINE immediate-release (MIR)


(Sevredol)

Prescription under medical supervision

Therapeutic action

Centrally acting opioid analgesic

Indications

Severe pain

Presentation

10 mg immediate-release tablet
10 mg/5 ml oral solution, for pediatric use

Dosage

There is no standard dose. The optimal dose is that which provides efficient pain relief to the
patient. It is adjusted in relation to the regular assessment of pain intensity and the incidence
of adverse effects.
Day 1:
Start with a scheduled treatment (scheduled doses):
Child over 6 months: 1 mg/kg/day in 6 divided doses at 4-hour intervals
Adult: 60 mg/day in 6 divided doses at 4-hour intervals
Adjust the treatment if pain persists by administering rescue doses between the
scheduled doses. The rescue doses administered are the same as the scheduled doses.
Then, adjust scheduled treatment every 24 hours according to the total dose given the day
before (i.e. total scheduled doses + total rescue doses).
For example, Day 1, for a dose of 60 mg/day, i.e. 10 mg every 4 hours:
2

10 mg

mild pain

10 mg

mild pain

10 mg moderate pain

10 mg

mild pain

mild pain

10 mg

10 mg

mild pain

Example
rescue
doses

10 11 12 13 14 15 16 17 18 19 20 21 22 23

10 mg moderate pain

severe pain

Example
simple
verbal scale

mild pain

10 mg

Scheduled
doses

10 mg moderate pain

Hours

In this example, the scheduled treatment on Day 2 is 90 mg/day, i.e. 60 mg (total scheduled
doses on Day 1) + 30 mg (total rescue doses on Day 1) in 6 divided doses, i.e. 15 mg every
4 hours.
Scheduled doses must be administered at regular time intervals and not on demand, even
at night, unless the patient is abnormally drowsy (in this event, delay the administration).
Reduce the dose by half in elderly patients and patients with renal or hepatic impairment.

Duration: once the pain is controlled, change to sustained-release morphine.


Contra-indications, adverse effects, precautions
See sustained-release oral morphine (MSR).

Remarks

104

Administer an appropriate laxative (e.g. lactulose) if analgesic treatment continues more


than 48 hours.
The morphine dose in tablets is not suitable for young children. Use oral solution instead.
If this is not available, use injectable morphine by the oral route: dilute an ampoule of
10 mg/ml (1 ml) with 9 ml of water to obtain a solution containing 1 mg/ml.
Morphine is on the list of narcotics: follow national regulations.
Storage: below 25C

MORPHINE sustained-release (MSR)


(Kapanol )

Prescription under medical supervision

Centrally acting opioid analgesic

Therapeutic action

Severe and persistent pain, especially cancer pain

Indications

10 mg, 30 mg and 60 mg sustained-release capsules or tablets

Presentation

Usually, the effective daily dose is determined during the initial treatment with immediaterelease morphine (MIR). When changing from MIR to MSR, the daily dose remains the
same. For example, if the effective dose of MIR is 20 mg 6 times/day (120 mg/day), the
dose of MSR is 60 mg 2 times/day (120 mg/day).

Dosage

If treatment is initiated directly with MSR:


Child over 6 months: initially 1 mg/kg/day in 2 divided doses at 12-hour intervals
Adult: initially 60 mg/day in 2 divided doses at 12-hour intervals
Adjust the dose if necessary, increasing the dose by 50% per day until pain relief is
obtained.

Patients stabilized on MSR may require rescue doses of MIR in the event of episodic
(breakthrough) pain. A rescue dose corresponds to 10% of the daily MSR dose. If a patient
regularly requires more than 3 rescue doses per day, increase the daily MSR dose by the
sum of rescue doses.
According to clinical response. Do not stop long-term treatment abruptly. Decrease doses
progressively to avoid withdrawal symptoms.

Duration

Do not administer to patients with severe respiratory impairment or decompensated


hepatic impairment.
Do not initiate treatment with the sustained-release formulation in elderly patients or those
with renal or hepatic impairment. Begin treatment with the immediate release formulation
(MIR).
May cause:
dose-related sedation and respiratory depression, nausea, vomiting, constipation, urinary
retention, confusion, raised intracranial pressure, pruritus;
in the event of overdose: excessive sedation, respiratory depression, coma.
Management of respiratory depression includes assisted ventilation and/or administration
of naloxone. Monitor patient closely for several hours.
Administer with caution to patients with respiratory impairment, head injury, raised intracranial pressure, uncontrolled epilepsy or urethroprostatic disorders.

Contra-indications, adverse effects, precautions

104

Do not combine with opioid analgesics with mixed agonist-antagonist activity such as
buprenorphine, nalbuphine, pentazocine (competitive action).
Increased risk of sedation and respiratory depression, when combined with alcohol and
drugs acting on the central nervous system: benzodiazepines (diazepam, etc.), neuroleptics
(chlorpromazine, haloperidol, etc.), antihistamines (chlorphenamine, promethazine),
phenobarbital, etc.
Pregnancy and breast-feeding: no contra-indication. The child may develop withdrawal symptoms,
respiratory depression and drowsiness when the mother receives morphine at the end of the 3rd trimester
and during breast-feeding. In these situations, administer with caution, for a short period, at the
lowest effective dose, and monitor the child.
Administer an appropriate laxative (e.g. lactulose) if analgesic treatment continues more
than 48 hours.
Do not crush or chew capsules. They can be opened and emptied into food.
Morphine is on the list of narcotics: follow national regulations.
Storage: below 25C

Remarks

105

MULTIVITAMINS VITAMIN B COMPLEX

Vitamin supplementation

Therapeutic action

Few indications: this drug has no effect in case of real vitamin deficiency. Nevertheless,
vitamin supplementation helps to prevent some deficiencies in people at risk (e.g. pregnant
women).

Indications

Tablet. Composition varies in quality and quantity, with manufacturers.


Examples of composition per tablet:

Presentation

Vitamin A
Vitamin B1
Vitamin B2
Vitamin B3 (= PP)
Vitamin C
Vitamin D3

Multivitamins
2500 IU
1 mg
0.5 mg
7.5 mg
15 mg
300 IU

B complex
/
1 mg
1 mg
15 mg
/
/

Daily needs (adult)


2500 IU
0.9 to 1.3 mg
1.5 to 1.8 mg
15 to 20 mg
10 mg
100 to 200 IU

Child under 5 years: 1 tab/day


Child over 5 years: 2 tab/day
Adult: 3 tab/day

Dosage

Duration: depending on situation

Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Specific vitamin deficiency states require appropriate doses of vitamins.


Multivitamins are not included in the WHO list of essential medicines.
Storage: keep in a cool place (8C to 15C)

Remarks

106

NALIDIXIC acid
(Negram)

Prescription under medical supervision

The WHO no longer recommends the use of


nalidixic acid for the treatment of shigellosis, even
in areas where it is still effective.

Antibacterial (group of quinolones)

Therapeutic action

Acute uncomplicated cystitis, without fever or lumbar pain

Indications

500 mg tablet

Presentation

Child over 3 months: 30 to 50 mg/kg/day in 4 divided doses for 7 days


Adult: 4 g/day in 4 divided doses for 7 days

Dosage and duration

Do not administer to patients with severe renal impairment, history of convulsions, G6PD
deficiency.
May cause: gastrointestinal disturbances, allergic reactions, photosensitivity, neurological
disorders (headache, dizziness, visual disturbances).
Administer with caution and reduce doses in patients with hepatic or renal impairment.
Pregnancy: CONTRA-INDICATED
Breast-feeding: CONTRA-INDICATED

Contra-indications, adverse effects, precautions

Due to its efficacy, safety and ease of administration, ciprofloxacin is the first-line antibiotic
for shigellosis and cystitis.
Once resistant to nalidixic acid, bacteria become very easily resistant to other quinolones
(ciprofloxacin, etc.).
Nalidixic acid is not included in the WHO list of essential medicines.
Storage: below 30C

Remarks

107

Revised November 2013

NEVIRAPINE = NVP
(Neravir, Nevimune,Viramune)

Prescription under medical supervision

Therapeutic action

Antiretroviral, HIV-1 non nucleoside reverse transcriptase inhibitor

Indications

HIV-1 infection, in combination with other antiretroviral drugs

Presentation

200 mg tablet
50 mg/5 ml oral suspension

Dosage

Child from 2 months to 8 years: 4 mg/kg once daily for 14 days, then 14 mg/kg/day in 2 divided
doses from the 15th day
Child over 8 years: 4 mg/kg once daily for 14 days, then 8 mg/kg/day in 2 divided doses from
the 15th day, without exceeding 400 mg/day
Adult: 200 mg once daily for 14 days, then 400 mg/day in 2 divided doses from the 15th day

Weight

5 to 9 kg
10 to 14 kg
15 to 19 kg
20 to 24 kg
25 to 29 kg
30 to 39 kg
40 to 49 kg
50 kg

10 mg/ml oral suspension


Initial
Maintenance
3 ml
6 ml x 2
5 ml
10 ml x 2
7 ml
14 ml x 2
< 8 years: 16 ml x 2
10 ml
> 8 years: 10 ml x 2
< 8 years: 20 ml x 2
12 ml
> 8 years: 12 ml x 2
14 ml
14 ml x 2

200 mg tablet
Initial
Maintenance

Use oral
suspension
1/2 tab x 2
1/2 tab
1 tab AM and 1/2 tab PM
< 8 years: 1 tab AM and 1/2 tab PM
1/2 tab
> 8 years: 1/2 tab x 2
< 8 years: 1 tab x 2
1/2 tab
> 8 years: 1/2 tab x 2
1 tab
1 tab AM and 1/2 tab PM
1 tab
1 tab x 2
1 tab
1 tab x 2

Duration: the duration of treatment depends on the efficacy and tolerance of nevirapine.
Contra-indications, adverse effects, precautions

Do not administer to patients with severe hepatic impairment, history of severe intolerance to
nevirapine that led to permanent discontinuation of treatment.
May cause:
cutaneous reactions sometimes severe (Lyell's and Stevens-Johnson syndromes), hepatic disorders
possibly severe (fulminant hepatitis). In these cases, stop taking nevirapine immediately and
permanently.
gastrointestinal disturbances, headache, myalgia.
Nevirapine reduces the efficacy of oestrogen-progestogen oral contraceptives: offer an alternative
or make sure that there is > 50 g ethinylestradiol per tablet.
Avoid combination with rifampicin (decreases the efficacy of nevirapine). If the administration
of rifampicin is required, use efavirenz rather than nevirapine.
Monitor liver enzyme level (ALAT) during the first 2 months, then every 3 to 6 months. If the
enzyme level reaches 5 times the normal level, stop nevirapine immediately.
Pregnancy: no contra-indication
Breast-feeding: not recommended

Remarks

108

For prophylactic treatment to reduce mother-to-child transmission, check national recommendations.


To improve tolerance, respect the initial 14-day phase of treatment. In the event of restarting
treatment after having stopped for more than 7 days, recommence initial 14-day phase.
Tablets are not scored. When half a tablet is required, use a cutter to cut the tablet into two
equal parts.
Also comes in fixed-dose combination tablets incorporating nevirapine-lamivudine-stavudine
(Triomune, Triviro).
Storage: below 30C
Once opened, oral suspension keeps for 2 months maximum.

NICLOSAMIDE
(Tredemine, Yomesan)

1
Anthelminthic (taenicide)

Therapeutic action

Taeniasis: beef tapeworm (Taenia saginata), pork tapeworm (Taenia solium), dwarf tapeworm
(Hymenolepis nana) and fish tapeworm (Diphyllobothrium latum)

Indications

500 mg chewable tablet

Presentation

T. saginata, T. solium and D. latum


Child under 2 years: 500 mg as a single dose
Child from 2 to 6 years: 1 g as a single dose
Child over 6 years and adult: 2 g as a single dose

Dosage and duration

H. nana
Child under 2 years: 500 mg on the first day, then 250 mg/day for 6 days
Child from 2 to 6 years: 1 g on the first day, then 500 mg/day for 6 days
Child over 6 years and adult: 2 g on the first day, then 1 g/day for 6 days

May cause: gastrointestinal disturbances.


Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Chew or crush the tablets before swallowing and washing down with water.
In the event of vomiting, the single dose may be divided in 2 doses taken with an interval
of one hour.
As niclosamide is a taenicide, do not expect the patient to expel the worm, portions are
voided in a partially digested form.
Niclosamide is not active against the larval form of T. solium (cysticercosis).
Storage: below 25C

Remarks

109

NICOTINAMIDE = VITAMIN PP = VITAMIN B3

Vitamin

Therapeutic action
Treatment of pellagra

Indications

50 mg tablet
Also comes in 100 mg tablet.

Presentation

Child and adult: 300 to 500 mg/day in 2 divided doses, with a diet rich in protein, until the
patient is fully cured

Dosage and duration

Pregnancy and breast-feeding: avoid, except if clearly needed (safety is not established)

Contra-indications, adverse effects, precautions

Nicotinamide is also called niacinamide.


Vitamin PP deficiency is common when diet is almost entirely based on sorghum, millet or
maize.
Vitamin PP deficiency often occurs in association with other vitamin B-complex deficiency
(thiamine, pyridoxine), especially in alcoholic patients.
Vitamin PP is usually one of the components of multivitamin preparations and B-complex
(7.5 mg to 15 mg/tablet).
Nicotinic acid has a similar action to nicotinamide, but is no longer used because of its
adverse effects, especially its vasodilator action.
Storage:

Remarks

110

NIFEDIPINE
(Adalat, AdalatLA)

Prescription under medical supervision

Therapeutic action

Uterine relaxant
Antihypertensive drug (calcium channel blocker)

Indications

Threatened premature labour


Hypertension

Presentation

10 mg short-acting (liquid-filled) capsule


10 mg prolonged-release tablet

Dosage

Threatened premature labour (short-acting capsule)


10 mg by oral route, to be repeated every 15 minutes if uterine contractions persist
(maximum 4 doses or 40 mg), then 20 mg by oral route every 6 hours
Hypertension (prolonged-release tablets)
20 to 100 mg/day in 2 divided doses or 20 to 90 mg once daily depending on the preparation
used

Duration

Threatened premature labour: 48 hours


Hypertension: lifetime treatment

Contra-indications, adverse effects, precautions

Do not administer to patients with severe cardiac disease (recent myocardial infarction,
unstable angina).
Do not administer if systolic blood pressure is below 90 mmHg.
May cause:
headache, flushing, peripheral oedema (common adverse effects at the start of
treatment);
dizziness, hypotension, tachycardia, nausea, gingival hyperplasia, rash.
Stop nifedipine if ischaemic chest pain occurs or existing pain increases shortly after
starting treatment.
Do not combine with magnesium sulphate, salbutamol IV, and calcium channel blockers.
Monitor combination with cimetidine (additive hypotension), phenytoin (risk of phenytoin
toxicity), rifampicin (efficacy of nifedipine diminished), itraconazole (increased risk of
oedema), beta-blockers (enhanced antihypertensive effects).
Pregnancy: CONTRA-INDICATED during the 1st trimester. Never administer sublingually (risk of
foetal death from placental hypoperfusion).
Breast-feeding: avoid

Remarks

For the management of hypertension in pregnancy, use labetalol or methyldopa.


Short-acting formulations of nifedipine should not be used in hypertension since their use
may cause excessive fall in blood pressure and cerebral or myocardial ischaemia.
Prolonged-release tablets must be swallowed whole.
Also comes in 20 mg, 30 mg, 60 mg and 90 mg prolonged-release tablets to be administered
once daily or to be administered twice daily. Follow manufacturer's instructions.
Storage: below 25C

111

NITROFURANTOIN
(Furadantin)

Prescription under medical supervision

Antibacterial (group of nitrofuranes)

Therapeutic action

Uncomplicated cystitis, without fever or lumbar pain

Indications

100 mg tablet
Also comes in 50 mg tablet or capsule and 25 mg/5 ml oral solution.

Presentation

Child over 3 months: 3 to 5 mg/kg/day in 3 divided doses for 5 to 7 days


Adult: 300 mg/day in 3 divided doses for 5 to 7 days

Dosage and duration


AGE

WEIGHT

50 mg tablet

100 mg tablet

3
months

Do not
administer

4
kg

1
year

1/4 tab

x3

8
kg

5
years
15
kg

1/4 to 1/2 tab

x3

1/2 to

15
years
35
kg

1 tab
x3
1/4 to 1/2 tab
x3

ADULT
2 tab x 3

1 tab x 3

Do not administer to patients with renal impairment, allergy to nitrofurantoin.


May cause: nausea, vomiting, allergic reactions; haemolytic anaemia in patients with G6PD
deficiency.
Do not administer simultaneously with antacids, administer 2 hours apart.
Pregnancy: CONTRA-INDICATED during the last month of pregnancy (risk of haemolysis in newborn)
Breast-feeding: avoid during the first month

Contra-indications, adverse effects, precautions

Take during meals.


Storage: below 25C

Remarks

112

NYSTATIN
(Mycostatin)

1
Antifungal

Therapeutic action
Oropharyngeal candidiasis

Indications

100 000 IU/ml oral suspension, bottle with calibrated dropper


Also comes in 100 000 IU lozenges to be sucked.

Presentation

Child and adult: 400 000 IU/day in 4 divided doses (1 ml of the oral suspension or one
lozenge to be sucked, 4 times daily) for 7 days
The oral suspension should be retained in the mouth for a few minutes before swallowing,
or, in young children, applied to the tongue and the inside of the cheeks.
Higher doses may be administered depending on the severity of the infection, especially in
HIV infected patients (up to 2 000 000 IU/day if necessary, e.g. 5 ml 4 times daily for
2 weeks).

Dosage and duration

Take between meals (e.g. at least 30 minutes before eating).


Shake oral suspension well before using.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

For the treatment of oropharyngeal candidiasis in immunocompromised patients, prefer


miconazole (muco-adhesive tablets) to nystatin.
Nystatin also comes in 100 000 IU and 500 000 IU film coated tablets for the treatment of
oesophageal candidiasis. These tablets are meant to be swallowed directly, without being
sucked. They should not be used for the treatment of oropharyngeal candidiasis as this
requires topical treatment.
For oesophageal candidiasis, oral fluconazole is recommended for first-line treatment. Film
coated nystatin tablets (400 000 IU/day in children and 2 000 000 IU/day in adults, in
4 divided doses for 2 to 3 weeks) should only be used when fluconazole is not available or
contra-indicated.
Storage: below 30C
Once the vial has been opened, the oral suspension keeps 7 days maximum.

Remarks

113

OMEPRAZOLE
(Mopral)

Prescription under medical supervision

Therapeutic action

Antiulcer drug (proton pump inhibitor)

Indications

Gastro-oesophageal reflux
Benign peptic ulcer
Complicated peptic ulcer (perforation, haemorrhage), for healing and preventing recurrence,
in combination with 2 antibacterial drugs to eradicate Helicobacter pylori

Presentation

20 mg capsule

Dosage and duration


Adult:

Gastro-oesophageal reflux
Short-term relief of symptoms: 20 mg once daily in the morning for 3 days
Treatment of gastro-oesophageal reflux disease: 20 mg once daily in the morning for
4 weeks (up to 8 weeks according to severity)
Benign peptic ulcer
20 mg once daily in the morning for 7 to 10 days

H. pylori eradication
40 mg/day in 2 divided doses for 10 days (in combination with metronidazole or tinidazole
+ amoxicillin or clarithromycin)

Contra-indications, adverse effects, precautions

May cause: headache, diarrhoea, skin rash, nausea, abdominal pain, dizziness.
Avoid combination with itraconazole and ketoconazole (decreases efficacy of these drugs).
Monitor combination with warfarin, digoxin, phenytoin.
Do not exceed 20 mg/day in patients with severe hepatic impairment.
Pregnancy: avoid during the 1st trimester (safety is not established)
Breast-feeding: not recommended

Remarks

Swallow capsules whole, do not chew.


For mild symptoms of gastro-oesophageal reflux, use antacids as first line treatment.
For peptic ulcer perforation: use omeprazole IV. As soon as the patient can eat, change to
oral treatment (omeprazole is equally effective when given IV or orally).
Storage: below 30C

114

ORAL REHYDRATION SALTS = ORS

Prevention and treatment of dehydration from acute diarrhoea, cholera, etc.

Indications

Sachet of powder to be diluted in 1 litre of clean water.


WHO formulation:
grams/litre
sodium chloride
2.6
sodium
glucose
13.5
chloride
potassium chloride
1.5
glucose
trisodium citrate
2.9
potassium
citrate
Total weight
20.5
Total osmolarity

Presentation

mmol/litre
75
65
75
20
10
245

Prevention of dehydration (WHO - Treatment plan A)


Child under 24 months: 50 to 100 ml after each loose stool (approximately 500 ml/day)
Child from 2 to 10 years: 100 to 200 ml after each loose stool (approximately 1000 ml/day)
Child over 10 years and adult: 200 to 400 ml after each loose stool (approximately 2000 ml/day)
Treatment of moderate dehydration (WHO - Treatment plan B)
Child and adult:
Over the first four hours:

Dosage

Age

Weight

ORS in ml

under
4 months

under 5 kg
200 to 400

4 to 11
months

5 to 7.9 kg
400 to 600

12 to 23
months

2 to 4 years 5 to 14 years

8 to 10.9 kg 11 to 15.9 kg 16 to 29.9 kg


600 to 800

15 years
and over

30 kg
and over

800 to 1200 1200 to 2200 2200 to 4000

After four hours:


If there are no signs of dehydration: follow Treatment plan A.
If there are signs of moderate dehydration: repeat Treatment plan B.
If there are signs of severe dehydration: start IV therapy (Treatment plan C).
Treatment of severe dehydration (WHO - Treatment plan C)
In combination with IV therapy and only to a conscious patient:
Child and adult: 5 ml/kg/hour
After 3 hours (6 hours in infants), reassess and choose the appropriate plan A, B or C.

Duration: as long as diarrhoea and signs of dehydration persist.

If the eyelids become puffy during the treatment: stop ORS, give plain water then, resume
ORS according to Treatment plan A when the puffiness is gone.
If case of vomiting, stop ORS for 10 min and then resume at a slower rate (very small,
frequent, amounts); do not stop rehydration.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

A special ORS-formula, ReSoMal, is used under medical supervision, for severely


malnourished children only. However, in malnourished children with cholera, standard
ORS-formula is used instead of ReSoMal.
Storage:
Do not use the powder if it has turned into a yellow-brownish sticky substance.
Once prepared, the solution must be used within 24 hours.

Remarks

115

PARACETAMOL = ACETAMINOPHEN
(Doliprane, Panadol)
Therapeutic action

Analgesic, antipyretic

Indications

Mild pain
Fever

Presentation

100 mg and 500 mg tablets or capsules


120 mg/5 ml oral suspension

Dosage

Child: 60 mg/kg/day in 3 or 4 divided doses


Adult: 3 to 4 g/day in 3 or 4 divided doses

AGE

WEIGHT

100 mg tablet

500 mg tablet

2
months

120 mg/5 ml oral solution

tab
x3

1/2

4
kg

2 ml x 3

3/4

1
year

5
years

8
kg

15
years

15
kg

35
kg

to 11/2 tab 11/2 to 3 tab

x3
x3
1/4 to 1/2 tab 1/2 to 11/2 tab

x3
x3

3 to 6 ml x 3

Maximum doses: child: 80 mg/kg/day; adult: 4 g/day

ADULT

2 tab x 3

Duration: according to clinical response

Contra-indications, adverse effects, precautions

Administer with caution to patients with hepatic impairment.


Do not exceed indicated doses, especially in children and elderly patients. Paracetamol
intoxications are severe (hepatic cytolysis).
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Remarks

For mild pain, paracetamol is used alone or in combination with an NSAID.


For moderate pain, paracetamol is used in combination with an NSAID and codeine or
tramadol.
For severe pain, paracetamol is used in combination with an NSAID and morphine.
Paracetamol is particularly recommended for patients allergic to aspirin, patients with a
history of gastric problems and for pregnant and breast-feeding women and children.
Paracetamol has no anti-inflammatory properties.
Storage: below 25C

116

PAROXETINE
Prescription under medical supervision
Therapeutic action

Antidepressant, selective serotonin re-uptake inhibitor (SSRI)

Indications

Major depression
Severe post-traumatic stress disorders

Presentation

20 mg scored tablet

Dosage

Adult: 20 mg once daily in the evening

Duration

6 months minimum. The treatment should be discontinued gradually (10 mg/day for one
week then, 10 mg on alternate days for one week). If signs of relapse occur, increase the
dose.

Contra-indications, adverse effects, precautions

Administer with caution and monitor use in patients with epilepsy, diabetes, history of
gastrointestinal bleeding or bipolar disorders.
May cause:
allergic reactions (rare): stop treatment;
drowsiness (caution when driving/operating machinery), gastrointestinal disturbances
(take during a meal), sexual dysfunction, headache, dizziness, blurred vision;
psychic disorders: exacerbation of anxiety, possibility of a suicide attempt at the beginning
of therapy, manic episode during the course treatment;
withdrawal symptoms (dizziness, paresthesia, nightmares, etc.) very frequent if the
treatment is discontinued abruptly.
Do not combine with another antidepressant.
Monitor combination with: phenytoin (toxicity increased), drugs which lower the seizure
threshold (antispychotics, mefloquine, tramadol, etc.), lithium and other serotonergics.
Avoid aspirin and NSAIDs (risk of bleeding) and alcohol during treatment.
Pregnancy: re-evaluate whether the treatment is still necessary; if it is continued, observe the newborn
infant if the mother was under treatment in the 3rd trimester (risk of irritability, tremors, hypotony,
sleeping disorders, etc.).
Breast-feeding: no contraindication

Remarks

The antidepressant effect is not immediate. It is necessary to wait 3 weeks before assessing
therapeutic efficacy. This must be explained to the patient.
In case of insufficient response after 4 weeks, dosage may be increased to 40 mg/day (do
not exceed 20 mg/day in the event of hepatic or renal impairment).
In elderly patients, SSRI are preferred to tricyclics (less contraindications, less adverse
effects).
Storage: no special temperature requirements

117

PHENOBARBITAL
(Gardenal, Luminal)

Prescription under medical supervision

Therapeutic action

Anticonvulsant, sedative and hypnotic

Indications

Epilepsy: tonic-clonic (grand mal) and partial (focal) seizures

Presentation

50 mg and 60 mg tablets
5.4% oral solution (1 drop = 1 mg)

Dosage

Follow national protocol.


For information:
Child: initial dose of 3 to 4 mg/kg once daily or in 2 divided doses, increase to
8 mg/kg/day if necessary
Adult: initial dose of 2 mg/kg once daily at bedtime (up to 100 mg maximum), then, increase
gradually if necessary, to the maximum dose of 6 mg/kg/day in 2 to 3 divided doses.

AGE

WEIGHT

Initial dose:

2
months
4
kg

1
year
8
kg

30 mg tablet

50 mg tablet

100 mg tablet

Duration: according to clinical response

1/2

5
years

15
years

15
kg

tab x 2

35
kg

ADULT

11/2 tab x 2

3 tab

1 tab

1 tab

1 tab x 2

2 tab

Contra-indications, adverse effects, precautions

Do not administer in respiratory depression.


May cause: drowsiness, depression of the central nervous system.
Do not stop treatment abruptly.
Risk of increased sedation when combined with alcohol and drugs acting on the central
nervous system such as diazepam, chlorphenamine, chlorpromazine, etc.
Decreases oral contraceptive efficacy.
Pregnancy: avoid
Breast-feeding: avoid

Remarks

118

Phenobarbital is subject to international controls: follow national regulations.


Plasma-concentrations are stable after 2 to 3 weeks. Caution: risk of accumulation.
If necessary, phenytoin may be combined with phenobarbital.
Also comes in 15 mg to 100 mg tablets.
Storage: below 25C

Revised September 2015

PHENOXYMETHYLPENICILLIN = PENICILLIN V
Prescription under medical supervision

Therapeutic action

Penicillin antibacterial

Indications

Streptococcal tonsillitis, scarlet fever


Completion treatment following parenteral therapy with penicillin

Presentation

250 mg tablet (400 000 IU)


Powder for oral suspension, 125 mg/5 ml (200 000 IU/5 ml), to be reconstituted with
filtered water

Dosage

Child under one year: 250 mg/day in 2 divided doses


Child 1 to 6 years: 500 mg/day in 2 divided doses
Child 6 to 12 years: 1 g/day in 2 divided doses
Child over 12 years and adult: 2 g/day in 2 divided doses

Age

< 1 year

1 to < 6 years

6 to < 12 years

12 years and adult

Duration

Weight

125 mg/5 ml oral susp.

250 mg tablet

10 to < 21 kg

2 tsp x 2

< 10 kg

21 to < 39 kg
39 kg

1 tsp x 2
4 tsp x 2

2 tab x 2
4 tab x 2

Streptococcal tonsillitis, scarlet fever: 10 days

Contra-indications, adverse effects, precautions

Do not administer to patients with allergy to penicillin.


Administer with caution to patients with allergy to cephalosporin (cross-sensitivity may
occur) or severe renal impairment (reduce dose).
May cause: diarrhea, nausea; allergic reactions sometimes severe.
Do not combine with methotrexate.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Remarks

Take between meals.


Also comes in 250 mg/5 ml (400 000 IU/5 ml) oral solution.

Storage: below 25C


For the oral suspension (powder or reconstituted suspension): follow manufacturers instructions.

119

PHENYTOIN
(Di-hydan, Dilantin, Epanutin)

Prescription under medical supervision

Anticonvulsant

Therapeutic action

Epilepsy, except absence seizure (petit mal)

Indications

100 mg tablet
Aslo comes in 25 mg and 50 mg tablets.

Presentation

Child: 3 to 8 mg/kg/day in 2 to 3 divided doses


Adult: 2 to 6 mg/kg/day in 2 to 3 divided doses; do not exceed 500 to 600 mg/day

Dosage
AGE

WEIGHT

100 mg tablet

2
months
4
kg

1
year
8
kg

5
years

tab
x2

1/2

15
kg

1/2

15
years

to 1 tab
x2

35
kg

1/2

ADULT
to 1 tab
x3

Duration: according to clinical response


Do not administer in case of hypersensitivity to phenytoin.
May cause:
gastro-intestinal disturbances: gingival hypertrophy, nausea, vomiting;
blood disorders: monitor blood counts if possible and administer folic acid in case of
prolonged use;
neurological disorders: dizziness, visual disturbances, mental confusion;
allergic reactions: cutaneous eruption, fever, adenopathy.
Do not stop treatment abruptly, decrease daily doses gradually.
It is not recommended to combine phenytoin with oral contraceptives, sulphonamides, or
chloramphenicol. Combination with other drugs must be closely monitored (diazepam,
phenobarbital, digoxin, corticosteroids, etc.).
Pregnancy: avoid
Breast-feeding: avoid

Contra-indications, adverse effects, precautions

Storage: below 30C


Never use phenytoin after expiry date (risk of underdosage).

Remarks

120

POTASSIUM CHLORIDE
immediate-release

Prescription under medical supervision

Therapeutic action

Potassium supplement, when immediate effect is required

Indications

Treatment of moderate hypokalaemia in patients with cholera

Presentation

7.5% potassium chloride syrup (1 mmol of K+/ml)

Dosage

Child under 13 years: 2 mmol (2 ml)/kg/day in 2 or 3 divided doses


Child 13 years and over and adult: 90 mmol (ml)/day in 3 divided doses
< 2 months

Age

2 months to < 1 year

Weight

7.5% syrup

5 to < 10 kg

6 ml x 2

< 5 kg

4 ml x 2

1 to < 3 years

10 to < 15 kg

12 ml x 2

5 to < 7 years

20 to < 25 kg

25 ml x 2

3 to < 5 years
7 to < 9 years

9 to < 13 years

13 years and adult

Duration

15 to < 20 kg
25 to < 30 kg
30 to < 45 kg
45 kg

20 ml x 2
20 ml x 3
25 ml x 3
30 ml x 3

According to clinical response. Treatment of 1 to 2 days is typically sufficient when the


patient is fully able to drink oral rehydration solution and can eat.

Contra-indications, adverse effects, precautions

Reduce dosage in elderly patients and patients with renal impairment (risk of hyperkalaemia).
Do not combine with spironolactone and angiotensin-converting-enzyme inhibitors (e.g.
enalapril).
May cause: gastrointestinal ulcerations, diarrhoea, nausea and vomiting, rarely hyperkalaemia.
Administer with caution in patients with gastrointestinal ulcer (risk of gastrointestinal
ulcerations).
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Remarks

Take with or at the end meals in order to reduce the risk of gastrointestinal ulcerations.
Hypokalaemia is defined as a serum potassium concentration below 3.5 mmol/l.
Storage: below 25C

121

Revised September 2015

POTASSIUM CHLORIDE
sustained-release

Prescription under medical supervision

Therapeutic action

Potassium supplement

Indications

Hypokalaemia induced by :
thiazide diuretics (e.g. hydrochlorothiazide)
loop diuretics (e.g. furosemide)

Presentation

600 mg potassium chloride sustained-release tablet (8 mmol of K+)

Dosage

Adult: 15 to 25 mmol/day = 2 to 3 tablets/day in 2 to 3 divided doses

Do not exceed indicated doses if potassium serum levels cannot be measured.

Duration

According to clinical response and duration of diuretic treatment

Contra-indications, adverse effects, precautions

Administer with caution and reduce dosage in elderly patients and in patients with renal
impairment (risk of hyperkalaemia).
Do not combine with spironolactone and angiotensin-converting-enzyme inhibitors (e.g.
enalapril).
May cause: hyperkalaemia, gastroduodenal ulcerations, diarrhoea, nausea and vomiting.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Remarks

Take with or at the end meals in order to reduce the risk of gastrointestinal ulcerations.
Hypokalaemia is defined as a serum potassium concentration below 3.5 mmol/l.
If tablets are not available, a lack of potassium may be corrected by a diet rich in dates,
bananas, mangos, oranges, tomatoes, etc.
Storage: below 25C

122

PRAZIQUANTEL
(Biltricide, Cysticide)

Prescription under medical supervision

Anthelminthic

Therapeutic action

Urinary (S. haematobium) and intestinal (S. mansoni, S. japonicum, S. mekongi, S. intercalatum)
schistosomiasis
Taeniasis (T. saginata, T. solium, H. nana)
Pulmonary (P. westermani), hepatobiliary (O. felineus, O. viverrini, C. sinensis) and intestinal
(F. buski, H. heterophyes, M. yokogawai) flukes

Indications

150 mg and 600 mg tablets

Presentation

Child over 2 years and adult:

Dosage and duration

Schistosomiasis
S. haematobium, S. mansoni, S. intercalatum: 40 mg/kg as a single dose or in 2 divided
doses administered 4 hours apart
S. japonicum, S. mekongi: 40 mg/kg as a single dose or 60 mg/kg in 2 to 3 divided doses
administered 4 hours apart
Taeniase
T. saginata, T. solium: 5 to 10 mg/kg as a single dose
H. nana: 25 mg/kg as a single dose

Fluke infections
lung: 75 mg/kg/day in 3 divided doses for 2 to 3 days
hepatobiliary: 75 mg/kg/day in 3 divided doses for 1 to 2 days
intestinal: 75 mg/kg in 3 divided doses, 1 day
Do not administer to patients with ocular cysticercosis.
May cause:
drowsiness, headache, gastrointestinal disturbances, dizziness; rarely: allergic reactions.
neurological disorders (headache, seizures) in patients with undiagnosed neurocysticercosis.
Pregnancy: no contra-indication for the treatment of schistosomiasis and taeniasis. If immediate
treatment not considered essential for fluke infections, it should be delayed until after delivery.
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Praziquantel is not active against certain liver flukes (Fasciola hepatica and gigantica). For
this indication, use triclabendazole.
Storage:

Remarks

122

PREDNISOLONE and PREDNISONE


Prescription under medical supervision
Steroidal anti-inflammatory drug (corticosteroid)

Therapeutic action

Symptomatic treatment of allergic and inflammatory diseases or reactions, e.g.:


Pneumocystis carinii (jiroveci) pneumonia with severe hypoxia
Certain severe forms of extra-pulmonary tuberculosis
Severe immune reconstitution syndrome, following initiation of antiretroviral or antituberculous treatment
Leprous neuropathy (especially reversal reaction)
Severe persistent asthma, in the event of treatment failure with high doses of inhaled
corticoids
Prevention of inflammatory reaction triggered by antiparasitic treatment (e.g. trichinellosis)

Indications

5 mg tablet

Presentation

The dose depends on indication, patients response and tolerance. If treatment lasts over
10 days, a high initial dose should be reduced as quickly as possible to the lowest effective
maintenance dose.
Child:
initial dose: 0.5 to 2 mg/kg/day maintenance dose: 0.25 to 0.5 mg/kg/day
Adult:
initial dose: 20 to 70 mg/day
maintenance dose: 5 to 15 mg/day
Administer preferably as a single daily dose, in the morning, with food.

Dosage

According to indication and clinical response. If the treatment lasts more than 3 weeks: do
not stop abruptly, reduce the daily dose gradually.

Duration

Do not administer to patients with active peptic ulcer (except if ulcer under treatment);
infections not controlled by a specific treatment; acute viral infection (e.g. hepatitis, herpes
simplex or zoster).
May cause (prolonged treatment with high doses): adrenal suppression, muscle atrophy,
growth retardation, increased susceptibility to infections, hypokalaemia, sodium and water
retention (oedema and hypertension), osteoporosis.
In the event of acute adrenal failure, use IV hydrocortisone.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication; take tablets just after a feed and wait 4 hours before the next
feed if possible.

Contra-indications, adverse effects, precautions

5 mg of prednisolone has the same anti-inflammatory activity as 5 mg of prednisone,


0.75 mg of dexamethasone and 20 mg of hydrocortisone.
Storage: below 30C

Remarks

123

PROMETHAZINE
(Phenergan)

Prescription under medical supervision

Sedating antihistamine

Therapeutic action

Symptomatic treatment of minor allergic reactions (contact dermatitis, seasonal allergy,


allergy to drugs, food, etc.)

Indications

25 mg tablet
Also comes in 10 mg tablet and in 5 mg/5 ml syrup.

Presentation

Child from 2 to 5 years: 10 mg/day in 2 divided doses or 5 to 15 mg once daily at bedtime


Child from 5 to 10 years: 10 to 25 mg/day in 2 divided doses or once daily at bedtime
Child over 10 years and adult: 25 to 75 mg/day in 3 divided doses or once daily at bedtime

Dosage

According to clinical response; single dose or for a few days

Duration

Do not administer to patients with prostate disorders or closed-angle glaucoma and to


children less than 2 years.
Administer with caution and monitor use in patients > 60 years and in children (risk of
agitation, excitability).
May cause: drowsiness (caution when driving/operating machinery), anticholinergic
effects (dry mouth, blurred vision, constipation, tachycardia, disorders of micturition),
headache, tremor, allergic reactions.
Monitor combination with CNS depressants (opioid analgesics, antipsychotics, sedatives,
antidepressants, etc.) and drugs known to have anticholinergic effects (amitryptiline,
atropine, carbamazepine, chlorpromazine, clomipramine, etc.).
Avoid alcohol during treatment.
Pregnancy: avoid at the end of pregnancy; no prolonged treatment.
Breast-feeding: no contra-indication; monitor the child for excessive somnolence.

Contra-indications, adverse effects, precautions

Storage: below 25C

Remarks

125

PYRANTEL
(Combantrin)

Anthelminthic

Therapeutic action

Ascariasis
Enterobiasis
Ancylostomiasis
Trichinellosis

Indications

250 mg pyrantel embonate chewable tablet


Oral suspension, 50 mg pyrantel embonate per ml

Presentation

Ascariasis
Child and adult: 10 mg/kg as a single dose

Dosage and duration

Enterobiasis
Child and adult: 10 mg/kg as a single dose followed by a second dose after 2 to 4 weeks

Ancylostomiasis
Child and adult: 10 mg/kg as a single dose; in severe infection, 10 mg/kg once daily for
4 days
Trichinellosis
Child and adult: 10 mg/kg once daily for 5 days

May cause: gastrointestinal disturbances, headache, dizziness, drowsiness, skin rash.


Reduce dosage in patients with hepatic impairment.
Pregnancy: avoid during the first trimester
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Preferably use albendazole or mebendazole for these indications. However, when these
drugs are contra-indicated, e.g. in children under one year, pyrantel is an alternative.
Storage:

Remarks

126

PYRAZINAMIDE = Z
Prescription under medical supervision
First line antituberculous antibacterial (sterilising and bactericidal activity)

Therapeutic action

Tuberculosis, in combination with other antituberculous antibacterials

Indications

400 mg tablet

Presentation

Child under 30 kg: 35 mg/kg (30 to 40 mg/kg/day) once daily


Child over 30 kg and adult: 25 mg/kg (20 to 30 mg/kg/day) once daily
Maximum dose: 2 g/day

Dosage

According to protocol

Duration

Do not administer to patients with hypersensitivity to pyrazinamide, severe hepatic


impairment or severe gout.
Reduce the dose in patients with renal impairment (25 mg/kg/dose 3 times per week).
May cause: gout and arthralgias, hepatic disorders (jaundice), photosensitivity (limit sun
exposure), rash, gastrointestinal disturbances, hypersensitivity reactions.
If signs of hepatotoxicity (e.g. jaundice) develop, pyrazinamide should be discontinued
until symptoms resolve.
Pregnancy: safety of pyrazinamide in the first trimester is not definitely established. However, given
the severity of the disease, it may be used during pregnancy.
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Pyrazinamide is included in the WHO Group 1 antituberculous agents.


For patients on first-line antituberculous treatment, pyrazinamide is given as part of a fixed
dose combination (isoniazid+rifampicin+pyrazinamide+ethambutol or isoniazid+ rifampicin+
pyrazinamide).

Storage: below 30C

Remarks

127

PYRIDOXINE = VITAMIN B6
(Benadon, Pyroxin)

Vitamin

Therapeutic action
Prevention and treatment of isoniazid-induced peripheral neuropathy

Indications

25 mg tablet
Also comes in 10 mg and 50 mg tablets.

Presentation

Prevention of isoniazid neuropathy


Child under 5 kg: 5 mg once daily
Child over 5 kg and adult: 10 mg once daily

Dosage

Treatment of isoniazid neuropathy


Child: 50 mg once daily
Adult: 150 mg/day in 3 divided doses

Prevention: as long as treatment with isoniazid continues.


Treatment: according to clinical response (in general, 3 weeks) then, preventive dose, as
long as treatment with isoniazid continues.

Duration

No contra-indication.
May cause: peripheral neuropathy in the event of prolonged use with doses 200 mg/day.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

In children receiving isoniazid prophylaxis or treatment for tuberculosis: concomitant


administration of pyridoxine at preventive dosage is recommended for children under
5 years and all children infected with HIV.
Pyridoxine is also used for the prevention and treatment of cycloserin-induced neuropathy
(150 to 200 mg/day in adults, in divided doses).
Storage:

Remarks

128

PYRIMETHAMINE
(Daraprim, Malocide)

Prescription under medical supervision

Antiprotozoal

Therapeutic action

Treatment and secondary prophylaxis of toxoplasmosis in immunodeficient patients, in


combination with sulfadiazine or clindamycin
Primary prophylaxis of toxoplasmosis in immunodeficient patients, in combination with
dapsone (only if cotrimoxazole cannot be used)
Second-line treatment of isosporiasis in immunodeficient patients (only if cotrimoxazole
cannot be used)

Indications

25 mg tablet

Presentation

Treatment of toxoplasmosis
Adult: 200 mg in 2 divided doses on the first day, then 75 to 100 mg/day for at least 6 weeks

Dosage and duration

Secondary prophylaxis of toxoplasmosis


Adult: 25 to 50 mg/day, as long as necessary

Primary prophylaxis of toxoplasmosis


Adult: 50 to 75 mg/week, as long as necessary
Treatment of isosporiasis
Adult: 50 to 75 mg/day for 10 days

Do not administer to patients with severe renal or hepatic impairment.


May cause: gastrointestinal disturbances, seizures, leucopenia, thrombocytopenia, megaloblastic anaemia due to folinic acid deficiency.
Administer calcium folinate to prevent folinic acid deficiency.
Avoid if possible combination with other folate antagonists: cotrimoxazole, methotrexate
(increased risk of folinic acid deficiency).
Monitor combination with zidovudine (increased risk of zidovudine-associated haematotoxicity).
Pregnancy: CONTRA-INDICATED during the first trimester
Breast-feeding: no contra-indication; however avoid concomitant administration of other folate
antagonists

Contra-indications, adverse effects, precautions

The combination of sulfadoxine/pyrimethmine (Fansidar) is used for the treatment of


uncomplicated falciparum malaria.
Storage: below 30C

Remarks

129

QUININE
Prescription under medical supervision

Therapeutic action
Antimalarial

Indications

Treatment of uncomplicated falciparum malaria


Completion treatment following parenteral therapy with quinine for severe falciparum
malaria

Presentation

200 mg and 300 mg quinine sulfate or bisulfate tablets

Dosage and duration

Dosage is expressed in terms of salt. With the exception of quinine bisulfate, the dosage is the
same for all quinine salts (sulfate, hydrochloride, dihydrochloride):
Child and adult 50 kg: 30 mg/kg/day in 3 divided doses at 8-hour intervals for 7 days
Weight

200 mg tablet

13 to 17 kg

3 to 6 kg

7 to 12 kg

18 to 25 kg
26 to 35 kg
36 to 50 kg
> 50 kg

1/4

tab x 3

1/2 tab

x3

1 tab x 3

2 tab x 3
3 tab x 3

300 mg tablet

1/2

tab x 3

1 tab x 3

2 tab x 3

Adult > 50 kg: 1800 mg/day in 3 divided doses at 8-hour intervals for 7 days
As bisulfate tablets contain a lower concentration of quinine, a higher dose is required:
40 mg/kg/day in children and 2.5 g/day in adults, in 3 divided doses.

Contra-indications, adverse effects, precautions

May cause: headache, skin rash; visual, auditory and gastrointestinal disturbances.
Do not exceed indicated doses: risk of toxicity in the event of overdose.
If the patient vomits within one hour after administration, repeat the full dose.
Do not combine with chloroquine, halofantrine and mefloquine.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Remarks

10 mg of quinine sulfate or hydrochloride or dihydrochloride = 8 mg of quinine base; 14 mg


of quinine bisulfate = 8 mg of quinine base.
In certain regions of South-East Asia, quinine is combined with doxycycline or clindamycin,
due to a reduction in P. falciparum sensitivity to quinine.
Quinine should not be used for prophylaxis.
Storage: below 30C

130

RESOMAL
Rehydration Solution for Malnutrition

Prescription under medical supervision

Oral rehydration salts with high potassium and low sodium contents

Therapeutic action

Prevention and treatment of dehydration, in patients suffering from complicated acute


malnutrition only

Indications

Sachet containing 84 g of powder, to be diluted in 2 litres of clean, boiled and cooled water
Sachet containing 420 g of powder, to be diluted in 10 litres of clean, boiled and cooled
water

Presentation

Composition for one litre


mmol/litre
Glucose
Saccharose
Sodium
Potassium
Chloride

55
73
45
40
70

Citrate
Magnesium
Zinc
Copper
Osmolarity

mmol/litre

7
3
0.3
0.045
294 mEq/litre

Prevention of dehydration
Child under 2 years: 50 to 100 ml after each loose stool as long as diarrhoea persists
Child over 2 years: 100 to 200 ml after each loose stool as long as diarrhoea persists
Adult: 200 to 400 ml after each loose stool as long as diarrhoea persists

Dosage and duration

Treatment of dehydration
Child and adult: 5 ml/kg every 30 minutes over the first 2 hours, then 5 to 10 ml/kg/hour
for the next 4 to 10 hours, until dehydration is corrected.
Do not administer to patients with cholera or uncomplicated acute malnutrition: use
standard ORS instead.
May cause: heart failure when administered too rapidly. During treatment, closely monitor
the rate of administration in order to avoid overhydration. Increase in respiratory and
pulse rates and appearance or increase of oedema are signs of over rapid rehydration. In
this event, stop ReSoMal for one hour then reassess the patients condition.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Storage: below 30C

Do not use the powder if it has turned sticky.


Once prepared, the solution should be used within 24 hours.

Remarks

131

RETINOL = VITAMIN A
Vitamin

Therapeutic action
Prevention of vitamin A deficiency
Treatment of vitamin A deficiency (xerophthalmia)

Indications

200 000 IU capsule


Also comes in 10 000 IU coated tablet, 50 000 IU capsule and 100 000 IU/ml oral solution.

Presentation

Prevention of vitamin A deficiency


Child under 6 months: 50 000 IU as a single dose
Child from 6 to 12 months: 100 000 IU as a single dose every 4 to 6 months
Child over 1 year: 200 000 IU as a single dose every 4 to 6 months
Treatment of vitamin A deficiency
Child under 6 months: 50 000 IU once daily on D1, D2 and D8 (or D15)
Child from 6 to 12 months: 100 000 IU once daily on D1, D2 and D8 (or D15)
Child over 1 year and adult: 200 000 IU once daily on D1, D2 and D8 (or D15)

Dosage and duration

AGE

6
months

6
kg

WEIGHT

Prevention
50 000 IU capsule

1
year

1 cap

5
years

8
kg

2 cap

15
kg

2 drops

4 drops

1 cap

200 000 IU capsule

2 drops

4 drops

1 cap

1 cap

2 cap

35
kg

ADULT

200 000 IU capsule

Treatment
50 000 IU capsule

15
years

1 cap

1 cap

Do not exceed indicated doses.


Overdosage may cause: gastrointestinal disturbances, headache, raised intracranial pressure
(bulging fontanelle in infants); foetal abnormalities.
Pregnancy:
Prevention: after delivery only, 200 000 IU as a single dose
Treatment: dosage depends on severity of eye lesions:
Night blindness and Bitot's spots: 10 000 IU once daily or 25 000 IU once weekly for at least 4 weeks
Corneal lesion: 200 000 IU once daily on D1, D2 and D8 (or D15)
Breast-feeding: no contra-indication at recommended doses

Contra-indications, adverse effects, precautions

Administer routinely 2 doses (on D1 and D2) to children suffering from measles to prevent the
complications of measles.
One 200 000 IU capsule contains about 8 drops (1 drop = 25 000 IU).
Storage: below 25C

Remarks

132

Revised November 2013

RIFAMPICIN = R

Therapeutic action

Prescription under medical supervision

First line antituberculous antibacterial (sterilising and bactericidal activity)


Antileprotic antibacterial (bactericidal activity)

Indications

Tuberculosis, in combination with other antituberculous antibacterials


Paucibacillary leprosy, in combination with dapsone
Multibacillary leprosy, in combination with dapsone and clofazimine

Presentation

150 mg and 300 mg tablets or capsules

Dosage

Tuberculosis
Child under 30 kg: 15 mg/kg (10 to 20 mg/kg/day) once daily, on an empty stomach
Child over 30 kg and adult: 10 mg/kg (8 to 12 mg/kg/day) once daily, on an empty stomach
Maximum dose: 600 mg/day
Paucibacillary and multibacillary leprosy
Child under 10 years: 12 to 15 mg/kg once monthly, on an empty stomach
Child from 10 to 14 years: 450 mg once monthly, on an empty stomach
Adult: 600 mg once monthly, on an empty stomach

Duration

Tuberculosis: according to protocol; paucibacillary leprosy: 6 months; multibacillary leprosy: 12 months

Contra-indications, adverse effects, precautions

Do not administer to patients with jaundice, hypersensitivity to rifamycins or history of


severe haematological disorders (thrombocytopenia, purpura) during a previous treatment
with rifamycins.
Avoid or administer with caution to patients with hepatic impairment (do not exceed
8 mg/kg/day).
May cause:
orange-red discoloration of body secretions (urine, tears, saliva, sputum, sweat, etc.),
normal, harmless;
gastrointestinal disturbances, headache, drowsiness, hepatic disorders;
influenza-like syndrome (more frequent when treatment is not taken regularly);
thrombocytopenia, hypersensitivity reactions.
If signs of hepatotoxicity (e.g. jaundice) develop, rifampicin should be discontinued until
symptoms resolve.
In patients taking nevirapine, indinavir, nelfinavir, lopinavir/ritonavir, atazanavir/ritonavir,
use rifabutin in place of rifampin.
Rifampicin reduces the effect of many drugs (antimicrobials, some hormones, antidiabetics,
corticoids, phenytoin, etc.):
In women, use a non-hormonal contraception or injectable medroxyprogesterone or, as
a last resort, use an oral contraceptive containing 50 g ethinylestradiol per tablet.
In the event of concomitant fluconazole administration, administer each drug 12 hours
apart (rifampicin in the morning, fluconazole in the evening).
For the other drugs, adjust dosage if necessary.
Pregnancy: no contra-indication. Risk of maternal and neonatal bleeding disorders when the mother
receives rifampicin in late pregnancy: administer phytomenadione (vitamin K) to the mother and the
newborn to reduce the risk.
Breast-feeding: no contra-indication

Remarks

Rifampicin is included in the WHO Group 1 antituberculous agents.


For patients on first-line antituberculous treatment, rifampicin is given as part of a fixed
dose combination (isoniazid+rifampicin+ pyrazinamide+ethambutol or isoniazid+rifampicin+
pyrazinamide or isoniazid+rifampicin).
For the treatment of single skin lesion paucibacillary leprosy, rifampicin (600 mg) + ofloxacin
(400 mg) + minocycline (100 mg) are administered as a single dose.
Rifampicin is also used in combination with co-trimoxazole for the treatment of brucellosis
in children < 8 years and pregnant/breastfeeding women.
Storage: below 30C

133

RISPERIDONE
(Risperdal)

Prescription under medical supervision

Atypical antipsychotic

Therapeutic action

Acute or chronic psychosis


Acute moderate to severe manic episode

Indications

1 mg tablet

Presentation

Acute or chronic psychosis


Adult: 2 mg in 2 divided doses on Day 1 then 4 mg/day in 2 divided doses as of Day 2.
The dose may be increased to 6 mg/day in 2 divided doses if needed.
Acute moderate to severe manic episode
Adult: 2 mg once daily; increase if necessary in steps of 1 mg/day (max. 6 mg/day).
Reduce the doses by half (initial and incremental doses) in elderly patients and in patients
with hepatic or renal impairment (max. 4 mg/day).

Dosage

Acute psychosis: minimum 3 months; chronic psychosis: minimum one year. The treatment
should be discontinued gradually (over 4 weeks). If signs of relapse occur, increase the
dose.
Manic episode: 3 to 6 weeks

Duration

Do not administer to elderly patients with dementia (e.g. Alzheimer's disease).


Administer with caution and monitor use in patients > 60 years and patients with
Parkinson's disease, cardiac, hepatic or renal impairment.
May cause: orthostatic hypotension, hyperprolactinaemia, sexual dysfunction, extrapyramidal syndrome, tachycardia, headache, nausea, agitation, anxiety, insomnia, drowsiness
(inform patients that it may affect their capacity to drive/operate machinery); neuroleptic
malignant syndrome (unexplained hyperthermia with neuromuscular disorders), rare but
requiring immediate treatment discontinuation.
In the event of extrapyramidal symptoms, combine with biperiden.
Avoid or monitor combination with: fluoxetine, carbamazepine, rifampicin, furosemide,
antihypertensives, CNS depressants (opioid analgesics, sedatives, H1 antihistamines, etc.).
Avoid alcohol during treatment.
Pregnancy: re-evaluate whether the treatment is still necessary; if it is continued, haloperidol or
chlorpromazine are in principle preferred as they are better known. However, if it is difficult to
change treatment at the beginning of pregnancy or if pregnancy is already in second trimester,
risperidone can be maintained. Observe the newborn infant the first few days (risk of hypertonia,
tremors, sedation).
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Atypical antipsychotics such as risperidone are less likely to cause extra-pyramidal adverse
effects than conventional antipsychotics.
Risperidone is not included in the WHO list of essential medicines.
Storage: no special temperature requirements

Remarks

134

RITONAVIR = RTV
(Norvir)

Prescription under medical supervision

Antiretroviral, HIV-1 and HIV-2 protease inhibitor

Therapeutic action

Booster for protease inhibitors (atazanavir, darunavir, saquinavir, etc.) in HIV-1 or HIV-2
infection. Ritonavir should not be used alone.

Indications

100 mg capsule
25 mg and 100 mg heat stable tablets
80 mg/ml oral solution, containing 43% alcohol (v/v)

Presentation

Adult:
Capsule: 100 mg once daily or 200 mg/day in 2 divided doses, depending on the
protease inhibitor co-administered
Oral solution: 1.25 ml once daily or 2.5 ml/day in 2 divided doses, depending on the
protease inhibitor co-administered

Dosage

Duration: depending on the efficacy and tolerance of ritonavir.

Do not administer to patients with severe hepatic impairment.


Adverse effects associated with the use of ritonavir as a booster are dependent on the other
protease inhibitor.
Ritonavir reduces the efficacy of oral contraceptives: use a non-hormonal contraception or
injectable medroxyprogesterone or make sure that the oral contraceptive used contains
50 g ethinylestradiol per tablet.
Administer with caution to patients with diabetes or haemophilia and, for oral solution, to
patients with hepatic disease or epilepsy.
Pregnancy: CONTRAINDICATED for oral solution; no contra-indication for capsules.

Contra-indications, adverse effects, precautions

Take with meals.


Also comes in fixed-dose combination tablets containing lopinavir-ritonavir (Kaletra).
Storage:
Capsule: to be kept refrigerated (2C to 8C). The patient may keep an opened bottle of capsules
for 30 days if stored below 25C.
Oral solution: between 20C to 25C for 30 days maximum. Do not refrigerate.

Remarks

135

SALBUTAMOL = ALBUTEROL
(Ventolin)

Prescription under medical supervision

Bronchodilator

Therapeutic action

Treatment of persistent asthma not controlled by inhaled corticosteroids

Indications

2 mg and 4 mg tablets
2 mg/5 ml syrup

Presentation

Child from 2 to 6 years: 3 to 6 mg/day in 3 divided doses


Child from 6 to 12 years: 6 mg/day in 3 divided doses
Child over 12 years and adult: 6 to 12 mg/day in 3 divided doses

Dosage

Duration: according to clinical response

Administer with caution to patients with diabetes mellitus, hyperthyroidism, arrhythmia,


angina, hypertension.
May cause: headache, tremor, tachycardia; hypokalaemia, hyperglycaemia.
Monitor combination with: furosemide, hydrochlorothiazide, corticosteroids, xanthines
(increased risk of hypokalaemia).
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

The use of oral salbutamol for this indication should only be considered when administration
of inhalated salbutamol is not feasible.
Oral salbutamol is not very effective in children under 2 years.
Oral salbutamol is not indicated in the management of acute asthma attack since its onset
of action is within 30 minutes.
Storage: below 30C

Remarks

136

SALBUTAMOL = ALBUTEROL aerosol


(Ventolin)

Prescription under medical supervision

Short-acting bronchodilator

Therapeutic action

Symptomatic treatment of asthma attack

Indications

Solution for inhalation in pressurised metered dose inhaler, 100 micrograms/puff

Presentation

Dosage depends on the severity of attack and patients response. For information :
2 to 4 puffs (up to 10 puffs depending on severity) every 10 to 30 minutes

Dosage

Shake the inhaler.


Breathe out as completely as possible. Place the lips tightly around the mouthpiece. Inhale
deeply while activating the inhaler. Hold breath 10 seconds before exhaling.
Co-ordination between the hand and inhalation is very difficult in children under 6 years,
elderly patients and patients with severe dyspnoea. Use a spacer to facilitate administration
and improve the efficacy of treatment.

Administration technique

May cause: headache, tremor and tachycardia.


In the event of bronchial infection, administer simultaneously with appropriate antibacterial
treatment.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Clean the mouthpiece before and after each use.


Do not pierce or incinerate used aerosol containers. Empty all residual gas, then bury.
Storage: below 30C

Remarks

137

SALBUTAMOL = ALBUTEROL nebuliser solution


(Ventolin)

Prescription under medical supervision

Bronchodilator

Therapeutic action

Symptomatic treatment of severe acute bronchospasm, e.g. in severe asthma attack

Indications

Solution for inhalation, in unit dose vial of 5 mg in 2.5 ml (2 mg/ml), to be administered


via a nebuliser

Presentation and route of administration

Child under 5 years or under 15 kg: 2.5 mg (1.25 ml)/nebulisation, to be repeated every
20 to 30 minutes if necessary
Child over 5 years and adult: 2.5 to 5 mg (1.25 to 2.5 ml)/nebulisation, to be repeated every
20 to 30 minutes if necessary
The nebuliser should always be driven by oxygen.

Dosage and duration

May cause: headache, tremor, tachycardia; hyperglycaemia and hypokalaemia (after large
doses); worsening hypoxia if administered without oxygen.
Never use nebuliser solution by the parenteral route.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Nebulised salbutamol should be reserved for severe asthma attacks when inhalation of
oxygen is also required. Otherwise, salbutamol should be delivered via a metered-dose
inhaler with a spacer: administration is easier and faster, the treatment is as effective, or
even more effective, than with a nebuliser and causes fewer adverse effects.
Volumes of nebuliser solution to be administered are insufficient to obtain efficient
nebulisation in most nebulisers: dilute salbutamol solution with 0.9% NaCl to obtain a total
volume of 4 ml in the reservoir of the nebuliser. The diluted solution is dispersed with
oxygen at a flow rate of 5 to 8 litres/min. Stop the nebulisation when the reservoir is empty
( 10-15 minutes).
Also comes in unit dose vials of 1.25 mg in 2.5 ml, 2.5 mg in 2.5 ml, and in vials of 50 mg
in 10 ml.
Storage: below 30C

Remarks

138

SAQUINAVIR = SQV
(Fortovase, Invirase)

Prescription under medical supervision

Antiretroviral, HIV-1 and HIV-2 protease inhibitor

Therapeutic action

HIV-1 or HIV-2 infection, in combination with two nucleoside reverse transcriptase


inhibitors and with low-doses of ritonavir as booster

Indications

200 mg capsule or soft capsule

Presentation

Adult: 2 g/day in 2 divided doses (in combination with 200 mg of ritonavir/day in 2 divided
doses)

Dosage

The duration of treatment depends on the efficacy and tolerance of saquinavir.

Duration

Do not administer to patients with severe hepatic impairment.


Do not administer to patients under 16 years of age.
May cause:
neurological disorders (peripheral neuropathy, paraesthesia), hepatic disorders (jaundice,
raised transaminases), metabolic disorders (lipodystrophy, hyperlipidaemia, diabetes
mellitus with glucose intolerance and/or insulin resistance),
gastrointestinal disturbances, headache, fatigue, fever, rash, pruritus; neutropenia,
thrombocytopenia, raised creatinine phosphokinase.
Do not combine with rifampicin (hepatotoxicity).
Administer with caution to patients with haemophilia (risk of haemorrhage) or renal or
hepatic impairment.
Pregnancy: no contra-indication
Breast-feeding: not recommended

Contra-indications, adverse effects, precautions

Take with meals or immediately after meals.


Storage:
Capsule: below 30C
Soft capsule: to be kept refrigerated (2C to 8C). The patient may keep an opened bottle of soft
capsules for 3 months if stored below 25C.

Remarks

139

SPIRONOLACTONE
(Aldactone, Spiroctan)

Prescription under medical supervision

Potassium-sparing diuretic, antagonist of aldosterone

Therapeutic action

Oedema associated with congestive heart failure, hepatic cirrhosis and nephrotic syndrome

Indications

25 mg tablet

Presentation

Oedema in congestive heart failure


Adult: 100 mg/day (up to 200 mg/day in severe cases) then, when oedema is controlled,
maintenance dose of 25 mg/day

Dosage

Ascites in hepatic cirrhosis


Adult: 100 to 400 mg/day. When weight is stable, administer the lowest possible maintenance
dose, in order to prevent adverse effects.
Oedema in nephrotic syndrome
Adult: 100 to 200 mg/day

The daily dose can be administered in 2 to 3 divided doses or once daily.

Duration: according to clinical response; avoid prolonged use.

Do not administer to patients with severe renal impairment, anuria, hyperkalaemia


> 5 mmol/l, hyponatraemia.
Do not combine with potassium salts, potassium-sparing diuretics; lithium (risk of lithium
toxicity).
Avoid or closely monitor combination with angiotensin-converting enzyme inhibitors (risk
of severe, potentially fatal hyperkalaemia), digoxin (risk of digoxin toxicity) and reduce
dosages.
May cause:
hyperkalaemia (especially in elderly or diabetics patients, patients with renal impairment
or patients taking NSAIDs), hyponatraemia; metabolic acidosis (in patients with decompensated cirrhosis).
gynecomastia, metrorrhagia, impotence, amenorrhoea, gastrointestinal disturbances,
headache, skin rash, drowsiness.
Administer with caution in patients with hepatic or renal impairment or diabetes.
Monitor regularly plasma-potassium levels.
Pregnancy: avoid, use only if clearly needed (risk of feminisation of foetus); spironolactone is not
indicated in the treatment of pregnancy-related oedema.
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

In children with oedema, the daily dose is 1 to 3 mg/kg/day.


Spironolactone is also used for the diagnosis and treatment of primary hyperaldosteronism.
Storage: below 30C

Remarks

140

STAVUDINE = d4T
(Stavir, Zerit, Zeritavir)

Prescription under medical supervision

Antiretroviral, HIV-1 and HIV-2 nucleoside reverse transcriptase inhibitor

Therapeutic action

HIV-1 or HIV-2 infection, in combination with other antiretroviral drugs

Indications

15 mg, 20 mg and 30 mg capsules


1 mg/ml, powder for oral solution

Presentation

Child over 3 months and under 25 kg: 2 mg/kg/day in 2 divided doses


Child 25 kg and adult: 60 mg/day in 2 divided doses

Dosage

Weight

5 to 9 kg

1 mg/ml
oral solution
7.5 ml x 2

10 to 14 kg

12.5 ml x 2

25 kg

15 to 19 kg
20 to 24 kg

18 ml x 2

15 mg

1 caps x 2

Capsules
20 mg

1 caps x 2
1 caps x 2

30 mg

1 caps x 2

Duration: depending on the efficacy and tolerance of stavudine.


Do not administer to patients with history of peripheral neuropathy or pancreatitis.
May cause:
peripheral neuropathy, metabolic disorders (lipodystrophy, hyperlipidaemia, etc.),
gastrointestinal disturbances (diarrhoea, nausea, vomiting, etc.);
lactic acidosis, severe pancreatic or hepatic disorders (in these events, stop antiretroviral
treatment; once the symptoms have resolved, prescribe an antiretroviral regimen
without stavudine).
Do not combine with zidovudine (antagonism); avoid combination with didanosine.
Reduce dosage in patients with renal impairment.
Pregnancy: no contra-indication. Do not combine with didanosine.

Contra-indications, adverse effects, precautions

Also comes in fixed-dose combination tablets containing stavudine-lamivudine-nevirapine


(Triomune) or stavudine-lamivudine (Coviro).
Storage: below 30C
Once prepared, the oral solution must be kept refrigerated (2C to 8C) and may be used for up to
30 days.

Remarks

141

STAVUDINE/LAMIVUDINE/NEVIRAPINE = d4T/3TC/NVP
(Triomune, Triviro)

Prescription under medical supervision

Combination of 3 antiretrovirals

Therapeutic action

HIV-1 infection

Indications

6 mg d4T/30 mg 3TC/50 mg NVP dispersible tablet


12 mg d4T/60 mg 3TC/100 mg NVP dispersible tablet
30 mg d4T/150 mg 3TC/200 mg NVP tablet

Presentation

Child less than 25 kg: see table below

Dosage

Weight

6 mg d4T/30 mg 3TC/50 mg NVP


tablet

12 mg d4T/60 mg 3TC/100 mg NVP


tablet

6 to 9 kg

1 1/2 tab x 2

20 to 24 kg

3 tab x 2

3 to 5 kg

10 to 13 kg
14 to 19 kg

1 tab x 2
2 tab x 2

2 1/2 tab x 2

1 tab x 2

1 1/2 tab x 2

Child 25 kg and adult: one 30 mg d4T/150 mg 3TC/200 mg NVP tablet twice daily

Duration: depending on the efficacy and tolerance of treatment.

Do not administer to patients with history of peripheral neuropathy, pancreatitis, hepatic


disorders or intolerance to nevirapine that led to discontinuation of treatment.
May cause:
adverse effects common to all 3 antiretrovirals: gastrointestinal disturbances;
adverse effects of stavudine: see stavudine;
adverse effects of lamivudine: see lamivudine;
adverse effects of nevirapine: see nevirapine.
Monitor if possible liver enzyme level (ALAT) during the first 2 months, then every
6 months. If the enzyme level reaches 5 times the normal level, stop nevirapine immediately.
Nevirapine reduces the efficacy of oral contraceptives: use a non-hormonal contraception
or injectable medroxyprogesterone or make sure that the oral contraceptive used contains
50 g ethinylestradiol per tablet.
Do not combine with zidovudine or rifampicin.
Pregnancy: no contra-indication

Contra-indications, adverse effects, precautions

To improve tolerance of NVP, administer half doses for the first 14 days of treatment.
Therefore, start triple therapy by using d4T/3TC co-formulations (Coviro) and nevirapine
tablets (Neravir, Nevimune, Viramune). After the initial 14-day phase of treatment,
use the co-formulation d4T/3TC/NVP.
Storage: below 25C

Remarks

142

SULFADIAZINE
(Adiazine)

Prescription under medical supervision

Sulfonamide antibacterial

Therapeutic action

Treatment and secondary prophylaxis of toxoplasmosis in immunodeficient patients, in


combination with pyrimethamine

Indications

500 mg tablet

Presentation

Treatment of toxoplasmosis
Adult: 4 to 6 g/day in 2 to 3 divided doses for 6 weeks minimum

Dosage and duration

Secondary prophylaxis of toxoplasmosis


Adult: 2 to 3 g/day in 2 divided doses, as long as necessary

Do not administer to sulfonamide-allergic patients; patients with severe renal or hepatic


impairment.
May cause:
gastrointestinal disturbances, renal disorders (crystalluria, etc.), photosensitivity,
megaloblastic anaemia due to folinic acid deficiency; haemolytic anaemia in patients
with G6PD deficiency,
allergic reactions (fever, rash, etc.) sometimes severe (Lyell's and Stevens-Johnson
syndromes, haematological disorders, etc.). In these cases, stop treatment immediately.
Adverse effects occur more frequently in patients with HIV infection.
Monitor blood count if possible.
Reduce the dose by half in patients with renal impairment.
Do not combine with methotrexate and phenytoin.
Administer calcium folinate systematically to prevent folinic acid deficiency.
Drink a lot of liquid during treatment.
Pregnancy: no contra-indication. However, avoid using during the last month of pregnancy (risk of
jaundice and haemolytic anaemia in the newborn infant).
Breast-feeding: avoid if premature infant, jaundice, low-birth weight, infant under one month of age.
If sulfadiazine is used, observe the infant for signs of jaundice.

Contra-indications, adverse effects, precautions

Storage:

Remarks

143

SULFADOXINE/PYRIMETHAMINE = SP
(Fansidar)

Prescription under medical supervision

Antimalarial

Therapeutic action
Treatment of uncomplicated falciparum malaria, in combination with artesunate
Completion treatment following parenteral therapy for severe falciparum malaria, in
combination with artesunate

Indications

Sulfadoxine 500 mg/pyrimethamine 25 mg co-formulated tablet

Presentation

Child and adult: 25 mg/kg sulfadoxine and 1.25 mg/kg pyrimethamine as a single dose

Dosage and duration


Age

500/25 mg tablet

2
months

1/2

tab

1
year

1 tab

7
years

2 tab

13
years

Adult

3 tab

Do not administer to patients with allergy to sulfonamides.


May cause: gastrointestinal disturbances; allergic reactions, sometimes severe (toxic
epidermal necrolysis and Stevens-Johnson syndrome); anaemia, leukopenia, agranulocytosis,
thrombocytopenia, haemolytic anaemia in patients with G6PD deficiency.
Do not use in combination with cotrimoxazole.
Do not give folic acid on the same day SP is administered, or within 15 days thereafter.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

In stable transmission areas, intermittent preventive treatments can be given to pregnant


women as of the 2nd trimester to reduce the consequences of malaria (anaemia, low birth
weight, etc.). Check national recommendations.
SP should not be used for malaria prophylaxis.
Storage: below 30C

Remarks

144

THIAMINE = VITAMIN B1
(Benerva, Betaxin)

1
Vitamin

Therapeutic action
Vitamin B1 deficiencies: beriberi, alcoholic neuritis

Indications

50 mg tablet
Also comes in 10 mg and 25 mg tablets.

Presentation

Dosage and duration

Infantile beriberi
10 mg once daily, until complete recovery (3 to 4 weeks)

Acute beriberi
150 mg/day in 3 divided doses for a few days, until symptoms improve, then 10 mg/day
until complete recovery (several weeks)
Mild chronic deficiency
10 to 25 mg once daily

No contra-indication, or adverse effects with oral thiamine.


Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

In the treatment of severe cases, the use of injectable thiamine is justified to correct the
disorder as rapidly as possible, but is no longer justified when symptoms have improved.
Vitamin B1 deficiency often occurs in association with other vitamin B-complex deficiencies,
especially in alcoholic patients.
Thiamine is also called aneurine.
Storage: in airtight non-metallic container

Remarks

145

TINIDAZOLE
(Fasigyn, Tindamax, Tindol)

Prescription under medical supervision

Antiprotozoal, antibacterial (group of nitroimidazoles)

Therapeutic action

Amoebiasis, giardiasis, trichomoniasis


Bacterial vaginitis, infections due to anaerobic bacteria (e.g. Clostridium sp, Bacteroides sp)

Indications

500 mg tablet

Presentation

Amoebiasis
Child: 50 mg/kg once daily, without exceeding 2 g
Adult: 2 g once daily
The treatment lasts 3 days in intestinal amoebiasis; 5 days in hepatic amoebiasis.

Dosage and duration

Giardiasis, trichomoniasis and bacterial vaginitis


Child: 50 mg/kg as a single dose, without exceeding 2 g
Adult: 2 g as a single dose
In the event of trichomoniasis, also treat sexual partner.

Infections due to anaerobic bacteria


Child over 12 years and adult: initially 2 g then 1 g once daily or in 2 divided doses
According to indication, tinidazole may be used in combination with other antibacterials;
treatment duration depends on indication.

Do not administer to patients with allergy to tinidazole or another nitroimidazole (metronidazole, secnidazole, etc.).
May cause: gastrointestinal disturbances; rarely: allergic reactions, brownish urine,
headache, dizziness. Risk of antabuse reaction when combined with alcohol.
Administer with caution in patients taking oral anticoagulants (risk of haemorrhage),
lithium, phenytoin (increased plasma concentrations of these drugs).
Pregnancy: no contra-indication; divide into smaller doses, avoid prolonged use.
Breast-feeding: significantly excreted in milk (risk of gastrointestinal disturbances in breastfed
infants); divide into smaller doses, avoid prolonged use.

Contra-indications, adverse effects, precautions

Storage: below 25C

Remarks

146

TRAMADOL
Prescription under medical supervision
Therapeutic action

Centrally acting analgesic (weak opioid, serotonin-norepinephrine reuptake inhibitor)

Indications

Moderate acute pain and moderate to severe chronic pain

Presentation

50 mg capsule
100 mg/ml oral solution

Dosage

Child over 6 months: 2 mg/kg every 6 hours


Adult: 50 to 100 mg every 4 to 6 hours, without exceeding 400 mg/day

Duration

According to clinical evolution. In the event of prolonged treatment, do not stop abruptly,
reduce doses progressively.

Contra-indications, adverse effects, precautions

Do not administer in the event of severe respiratory depression and to patients that risk
seizures (e.g. epilepsy, head injury, meningitis).
May cause:
dizziness, nausea, vomiting, drowsiness, dry mouth, sweating;
rarely: allergic reactions, seizures, confusion;
exceptionally: withdrawal symptoms; respiratory depression in the event of overdosage.
Do not combine with opioid analgesics, including codeine.
Avoid combination with carbamazepine, fluoxetine, chlorpromazine, promethazine,
clomipramine, haloperidol, digoxin.
Reduce doses (1 mg/kg) and administer every 12 hours in elderly patients and in patients
with severe renal or hepatic impairment (risk of accumulation).
Pregnancy and breast-feeding: no contra-indication. The child may develop adverse effects (drowsiness)
when the mother receives tramadol at the end of the 3rd trimester and during breast-feeding. In these
events, administer with caution, for a short period, at the lowest effective dose, and monitor the child.

Remarks

Oral solution is available in bottle containing 20 drops/ml (1 drop = 5 mg) and 40 drops/ml
(1 drop = 2.5 mg).
Doses administered for the treatment of neuropathic pain are often lower than those
administered for the treatment of acute pain.
Tramadol is approximately 10 times less potent than morphine.
In some countries, tramadol is on the list of narcotics: follow national regulations.

Storage:

147

TRANEXAMIC acid
(Cyclokapron, Exacyl...)

Prescription under medical supervision

Antifibrinolytic

Therapeutic action

Metrorrhagia (especially functional uterine bleeding) and menorrhagia

Indications

500 mg tablet

Presentation

Adult: 3 g/day in 3 divided doses (max. 4 g/day in 4 doses) during bleeding

Dosage

Duration: 3 to 5 days

Do not administer in patients with (or with history of) venous or arterial thromboembolic
disease.
Administer with caution in the event of haematuria of renal origin (risk of anuria).
May cause: gastrointestinal disturbances; rarely, allergic reactions, seizures.
Pregnancy: this drug is not indicated in the event of bleeding during pregnancy.
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

The treatment may given at each bleeding episode. In situations of repeated bleeding, it
may be helpful to combine tranexamic acid with a non-steroidal anti-inflammatory drug
(oral ibuprofen, 1200 to 2400 mg/daily maximum, to be divided in 3 doses for 3 to 5 days)
and/or a long-term treatment with oral estroprogestogens or injectable progestogens.
Storage: no special temperature requirements

Remarks

148

TRICLABENDAZOLE
(Egaten, Fasinex)

Prescription under medical supervision

Anthelminthic

Therapeutic action

Fascioliasis (Fasciola hepatica and Fasciola gigantica infections)


Paragominiasis

Indications

250 mg tablet

Presentation

Fascioliasis
Child and adult: 10 mg/kg as a single dose

Dosage and duration

Paragominiasis
Child and adult: 20 mg/kg in 2 divided doses
Do not administer to patients with hypersensitivity to triclabendazole or other benzimidazoles (albendazole, flubendazole, mebendazole, tiabendazole).
May cause: abdominal pain, mild fever, headache, dizziness.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Take tablets after meals.


Due to its efficacy, good tolerance, and ease of administration, triclabendazole is the drug
of choice for fascioliasis.
Bithionol (Bitin, Lorothidol) may be used as an alternative to triclabendazole in the
treatment of fascioliasis: 30 mg/kg/day for 5 days.
Unlike infections with other flukes, fascioliasis does not respond to praziquantel.
Storage: below 30C

Remarks

149

VALPROIC acid = SODIUM VALPROATE


(Convulex, Depakine, Epilim...)

Prescription under medical supervision

Antiepileptic

Therapeutic action
Generalised and partial epilepsy

Indications

200 mg and 500 mg enteric coated tablets


Also comes in 200 mg/5 ml oral solution.

Presentation

Child under 20 kg: 20 mg/kg/day in 2 divided doses


Child over 20 kg: initially 400 mg (irrespective of weight) in 2 divided doses, then increase the
dose gradually until the optimal dose is reached, usually 20 to 30 mg/kg/day in 2 divided
doses
Adult: initially 600 mg/day in 2 divided doses, then increase by 200 mg every 3 days until
the optimal dose is reached, usually 1 to 2 g/day in 2 divided doses (20 to 30 mg/kg/day)

Dosage

Duration: lifetime treatment

Do not administer to patients with pancreatitis, hepatic disease (or history of).
May cause:
increase in the frequency of seizures at the beginning of therapy, weight gain, gastrointestinal disturbances, hepatic dysfunction,
rarely: pancreatitis, extrapyramidal symptoms, cognitive disorders and behavorial
disturbances, confusion, severe allergic reactions (Lyells and Stevens-Johnson syndromes),
amenorrhoea; thrombocytopenia, prolongation of bleeding time.
Monitor, if possible, liver transaminase concentrations and prothrombine time during first
3-6 months of therapy.
Stop treatment in the event of jaundice or gastrointestinal manifestations of hepatitis,
significant lasting increase of transaminases, prolonged prothrombine time.
Reduce dosage in patients with renal impairment.
Do not combine with mefloquine (increased risk of seizures).
Monitor combination with: tricyclic antidepressants, other antiepileptics.
If other antiepileptic drugs have been prescribed, reduce the dose of these drugs and
increase the dose of valproic acid gradually over 2 weeks.
Pregnancy: risk of neural tube defect, limb malformations and craniofacial abnormalities, if used
during the first trimester. Do not start treatment during the first trimester, except if vital and there
is no alternative. However, if treatment has been started before a pregnancy, do not stop treatment,
administer the daily dose in smaller fractioned doses and monitor the newborn infant (risk of
haemorrhagic disease, non related to vitamin K deficiency).
The administration of folic acid before conception and during the first trimester seems to reduce the
risk of neural tube defect.
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Take with meals.


Storage: below 30C

Remarks

150

ZIDOVUDINE = AZT = ZDV


(Retrovir)

Prescription under medical supervision

Antiretroviral, HIV-1 and HIV-2 nucleoside reverse transcriptase inhibitor

Therapeutic action

HIV-1 or HIV-2 infection, in combination with other antiretroviral drugs

Indications

100 mg and 250 mg capsules and 300 mg tablet


50 mg/5 ml oral solution

Presentation

Premature infant: 3 mg/kg/day in 2 divided doses for the first 2 weeks after birth then
8 mg/kg/day in 2 divided doses
Child under 4 weeks: 8 mg/kg/day in 2 divided doses
Child from 4 weeks to 13 years: 360 to 480 mg/m2/day in 2 divided doses
Adult: 600 mg/day in 2 divided doses

Dosage

Oral solution
10 mg/ml

100 mg capsule

250 mg capsule

300 mg tablet

10 to 14 kg

12 ml x 2

1 cap x 2

25 to 29 kg

25 ml x 2

3 cap x 2

Weight

5 to 6 kg
7 to 9 kg

15 to 19 kg
20 to 24 kg
30 to 39 kg
40 kg

6 ml x 2
8 ml x 2

17 ml x 2
20 ml x 2
28 ml x 2

2 cap x 2
2 cap x 2
3 cap x 2
3 cap x 2

1 cap x 2
1 cap x 2

1 tab x 2
1 tab x 2
1 tab x 2

The duration of treatment depends on the efficacy and tolerance of zidovudine.

Duration

Do not administer to patients with severe haematological disorders (leukopenia, anaemia),


to neonates with hyperbilirubinaemia or raised transaminases.
May cause: haematological disorders (monitor CBC), gastrointestinal disturbances (nausea,
diarrhoea, etc.), headache, myopathy, hepatic disorders, lactic acidosis. Stop taking zidovudine in the event of severe haematological disorders or hepatic disorders (hepatomegaly, raised transaminases).
Reduce dosage in patients with severe renal or hepatic impairment.
Do not combine with stavudine.
Pregnancy: no contra-indication
Breast-feeding: not recommended

Contra-indications, adverse effects, precautions

For prophylactic treatment to reduce mother-to-child transmission, check national recommendations.


Also comes in fixed-dose combination tablets incorporating zidovudine-lamivudine
(Combivir) and zidovudine-lamivudine-abacavir (Trizivir).
Storage: below 30C. For capsules:

Remarks

151

ZIDOVUDINE/LAMIVUDINE = AZT/3TC
(Avocomb, Combivir, Duovir)

Prescription under medical supervision

Combination of 2 antiretrovirals, HIV-1 and HIV-2 nucleoside reverse transcriptase inhibitors

Therapeutic action

HIV-1 or HIV-2 infection, in combination with another antiretroviral drug

Indications

60 mg AZT/30 mg 3TC tablet


300 mg AZT/150 mg tablet

Presentation

Child less than 25 kg: see table below

Dosage

Weight

60 mg AZT/30 mg 3TC tablet

6 to 9 kg

1 1/2 tab x 2

14 to 19 kg

2 1/2 tab x 2

3 to 5 kg
10 to 13 kg
20 to 24 kg

1 tab x 2
2 tab x 2
3 tab x 2

Child 25 kg and adult: one 300 mg AZT/150 mg 3TC tablet twice daily

Duration: depending on the efficacy and tolerance of treatment.

Do not administer to patients with severe haematological disorders (neutropenia, anaemia).


May cause:
adverse effects common to all 2 antiretrovirals: gastrointestinal disturbances;
adverse effects of zidovudine: see zidovudine;
adverse effects of lamivudine: see lamivudine.
Do not combine with stavudine.
Pregnancy: no contra-indication

Contra-indications, adverse effects, precautions

Storage: below 30C

Remarks

152

ZIDOVUDINE/LAMIVUDINE/NEVIRAPINE = AZT/3TC/NVP
(Avocomb N, Duovir N)

Prescription under medical supervision

Combination of 3 antiretrovirals

Therapeutic action

HIV-1 infection

Indications

60 mg AZT/30 mg 3TC/50 mg NVP dispersible tablet


300 mg AZT/150 mg 3TC/200 mg NVP tablet

Presentation

Child less than 25 kg: see table below

Dosage

Weight

60 mg AZT/30 mg 3TC/50 mg NVP tablet

6 to 9 kg

1 1/2 tab x 2

14 to 19 kg

2 1/2 tab x 2

3 to 5 kg
10 to 13 kg
20 to 24 kg

1 tab x 2
2 tab x 2
3 tab x 2

Child 25 kg and adult: one 300 mg AZT/150 mg 3TC/200 mg NVP tablet twice daily

Duration: depending on the efficacy and tolerance of treatment.

Do not administer to patients with severe haematological disorders (neutropenia, anaemia),


hepatic disorders or intolerance to nevirapine that led to discontinuation of treatment.
May cause:
adverse effects common to all 3 antiretrovirals: gastrointestinal disturbances;
adverse effects of zidovudine: see zidovudine;
adverse effects of lamivudine: see lamivudine;
adverse effects of nevirapine: see nevirapine.
Monitor if possible liver enzyme level (ALAT) during the first 2 months, then every 6 months.
If the enzyme level reaches 5 times the normal level, stop nevirapine immediately.
Nevirapine reduces the efficacy of oral contraceptives: use a non-hormonal contraception
or injectable medroxyprogesterone or make sure that the oral contraceptive used contains
50 g ethinylestradiol per tablet.
Do not combine with stavudine or rifampicin.
Pregnancy: no contra-indication

Contra-indications, adverse effects, precautions

To improve tolerance of NVP, administer half doses for the first 14 days of treatment.
Therefore, start triple therapy by using AZT/3TC co-formulations (Avocomb,
Combivir, Duovir) and nevirapine tablets (Neravir, Nevimune, Viramune). After
the initial 14-day phase of treatment, use the co-formulation AZT/3TC/NVP.
Storage: below 30C

Remarks

153

ZINC SULFATE

Micronutrient

Therapeutic action

Zinc supplementation in combination with oral rehydration therapy in the event of acute
and/or persistent diarrhoea in children under 5 years

Indications

20 mg scored and dispersible tablet, packed in a blister


20 mg/5 ml syrup

Presentation

Child under 6 months: 10 mg once daily (1/2 tablet or 1/2 teaspoon once daily) for 10 days
Child from 6 months to 5 years: 20 mg once daily (1 tablet or 1 teaspoon once daily) for
10 days

Dosage and duration

Place the half-tablet or full tablet in a teaspoon, add a bit of water to dissolve it, and give the
entire spoonful to the child.

No contra-indication.
If the child vomits within 30 minutes after swallowing the tablet, re-administer the dose.
Do not give simultaneously with ferrous salts, administer at least 2 hours apart.

Contra-indications, adverse effects, precautions

Zinc sulfate is given in combination with oral rehydration solution in order to reduce the
duration and severity of diarrhoea, as well as to prevent further occurrences in the 2 to
3 months after treatment. Zinc sulfate must never replace oral rehydration therapy which
is essential (nor can it replace antibiotic therapy that may, in specific cases, be necessary).
Zinc supplementation is not recommended in the event of diarrhoea in malnourished
children taking therapeutic food (BP100, Plumpy' nut, milk F75 or F100, etc.) as these
foods already contain the required amount of zinc.

Storage: below 30C


Tablets are packed in a blister. Leave tablets in blister until use. Once a tablet is removed from the
blister, it must be dissolved and administered immediately.

Remarks

154

Injectable drugs
Acetaminophen
Adrenaline
Albuterol
Amoxicillin
Amoxicillin/clavulanic acid
Amphotericin B conventional
Amphotericin B liposomal
Ampicillin
Artemether
Artesunate (AS)
Atropine
Benzathine benzylpenicillin
Benzylpenicillin
Benzylpenicillin procaine
Benzylpenicillin procaine/
benzylpenicillin
Butylscopolamine
Calcium gluconate
Ceftriaxone
Chloramphenicol
Chloramphenicol long-acting oil
Chlorpromazine
Clindamycin
Cloxacillin
Co-amoxiclav
Dexamethasone
Dextrose 50%
Diazepam
Diclofenac
Digoxin
Dipyrone
Eflornithine
Epinephrine (EPN)
Etonogestrel implant
Fortified penicillin procaine
Fluconazole
Furosemide = frusemide
Gentamicin
Glucose 50%
Haloperidol
Heparin
Hydralazine
Hydrocortisone

Hyoscine butylbromide
Insulin
Insulin intermediate-acting
Insulin long-acting
Insulin short-acting
Ketamine
Labetalol
Levonorgestrel implant
Lidocaine = lignocaine
Magnesium sulfate
Medroxyprogesterone
Melarsoprol
Metamizole
Methylergometrine
Metoclopramide
Metronidazole
Morphine
Naloxone
Noramidopyrine
Omeprazole
Oxytocin
Paracetamol
Penicillin G
Penicillin G procaine
Pentamidine
Phenobarbital
Phytomenadione
Potassium chloride 10%
Promethazine
Protamine
Quinine
Salbutamol
Sodium bicarbonate 8.4%
Spectinomycin
Streptomycin (S)
Suramin
Thiamine
Tramadol
Vitamin B1
Vitamin K1

AMOXICILLIN/CLAVULANIC acid = CO-AMOXICLAV


(Augmentin)
Prescription under medical supervision

Penicillin antibacterial

Therapeutic action

Severe postpartum upper genital tract infection, in combination with gentamicin

Indications

Powder for injection, in vial containing 1 g amoxicillin/200 mg clavulanic acid, to be


dissolved in 20 ml water for injection or 0.9% sodium chloride, for slow IV injection (over
3 minutes) or infusion (in 50 ml of 0.9% sodium chloride over 30 minutes). DO NOT DILuTE
wITH GLuCOSE SOLuTION.

Presentation and route of administration

Dosage (expressed in amoxicillin)

Adult: 3 g/day in 3 divided doses

Duration: change to oral treatment as soon as possible


Do not administer to penicillin-allergic patients and patients with history of hepatic
disorders during a previous treatment with co-amoxiclav.
Administer with caution to patients allergic to cephalosporins (cross-sensitivity may
occur).
Administer with caution to patients with hepatic impairment; reduce dosage and give
every 12 to 24 hours in patients with severe renal impairment.
May cause: diarrhoea; allergic reactions, sometimes severe (stop treatment immediately);
jaundice and cholestatic hepatitis in the event of prolonged treatment (> 10 to 15 days).
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Do not mix with other drugs in the same syringe or infusion bag.
The addition of clavulanic acid to amoxicillin extends its spectrum of activity to cover betalactamase producing Gram-positive and Gram-negative organisms, including some Gramnegative anaerobes.
Storage: no special temperature requirements
Once reconstituted, the solution must be used immediately; discard any unused open vial.

Remarks

157

AMPHOTERICIN B conventional
(Fungizone)

Antifungal

Prescription under medical supervision

Therapeutic action
Cryptococcal meningitis in combination with flucytosine or fluconazole
Severe histoplasmosis or penicilliosis

Indications

Powder for injection, in 50 mg vial, to be dissolved in 10 ml of water for injection, to obtain


a concentrated solution containing 5 mg/ml. The concentrated solution must be diluted in
500 ml of 5% glucose to obtain a solution containing 0.1 mg/ml, for slow IV infusion.

Presentation and route of administration

Child and adult: 0.7 to 1 mg/kg/day over 4 to 6 hours depending on tolerance, for 2 weeks
(cryptococcosis, penicilliosis) or 1 to 2 weeks (histoplasmosis)

Dosage and duration

Administer with caution to patients with renal impairment.


May cause:
intolerance reactions during administration: fever, chills, headache, nausea, vomiting,
hypotension; local reaction: pain and thrombophlebitis at injection site; allergic reactions;
muscle or joint pain, cardiovascular disorders (arrhythmias, heart failure, hypertension,
cardiac arrest), neurologic (seizures, blurred vision, dizziness), haematological or hepatic
disorders;
disturbances in renal function (reduced glomerular filtration, hypokalaemia, hypo magnesiemia).
Avoid combination with: drugs causing hypokalaemia (furosemide, corticosteroids),
nephrotoxic drugs (amikacin, ciclosporine); digoxin, zidovudine, tenofovir.
To prevent renal toxicity, administer routinely 500 ml to 1 litre of 0.9% sodium chloride or
Ringer lactate prior to each amphotericin B infusion.
In adults, as soon as the patient can swallow, give supplements of potassium (4 tab of
8 mmol/day in 2 divided doses) and magnesium (1 g/day in 2 divided doses) until the end
of amphotericin treatment.
In the event of intolerance, stop infusion, give paracetamol or an antihistamine then, resume
administration reducing infusion rate by half.
Monitor serum creatinine levels, and if possible, serum potassium levels (once to twice
weekly) throughout treatment.
If serum creatinine levels rise by over 50%, increase preventive hydration (1 litre every
8 hours) or stop treatment. Then, after improvement, resume amphotericin at the lowest
effective dose or on alternate days.
use liposomal amphotericin B (AmBisome) if serum creatinine levels increase again or if
clearance is < 30 ml/minute or in patients with pre-existing severe renal failure.
Pregnancy: check for renal dysfunction in the newborn if administered during the last month of
pregnancy.
Breast-feeding: avoid, except if vital

Contra-indications, adverse effects, precautions

Only use 5% glucose for administration (incompatible with other infusion fluids). Do not
use the preparation if there is visible precipitation (the glucose solution is too acid).
Do not add other drugs in the infusion bottle or bag.
Protect infusion bottle from light during administration (wrap in dark paper).
For cryptococcosis, fluconazole alone at high dose may be an alternative when amphotericin B (conventional or liposomal formulation) cannot be used.
Storage:
Vial of powder: must be kept refrigerated (between 2C and 8C); in the absence of a refrigerator,
7 days maximum, below 25C.
Concentrated solution (5 mg/1 ml): may be kept refrigerated 24 hours (between 2C and 8C).
Solution for infusion (0.1 mg/ml): must be used immediately.

Remarks

158

AMPHOTERICIN B liposomal
(Ambisome)

Prescription under medical supervision

Antifungal

Therapeutic action
Cryptococcal meningitis, when conventional amphotericin B is contra-indicated (severe
pre-existing renal impairment or amphotericin B induced renal impairment)
Cutaneomucous or visceral leishmaniasis
Severe histoplasmosis

Indications

Powder for injection, in 50 mg vial, to be dissolved in 12 ml of water for injection, to obtain


a concentrated suspension containing 4 mg/ml.
with a syringe, withdraw the required dose of concentrated suspension. Attach the filter
provided with the vial to the syringe; inject the contents of the syringe, through the filter,
into the volume of 5% glucose (50 ml, 250 ml, 500 ml) needed to obtain a solution containing
between 0.2 to 2 mg/ml, for IV perfusion.

Presentation, preparation and route of administration

Cryptococcal meningitis, severe histoplasmosis


Child over 1 month and adult: 3 mg/kg once daily over 30 to 60 minutes for 2 weeks

Dosage and duration

weight
4 kg
5 kg
6 kg
7 kg
8 kg
9 kg
10 kg
15 kg
20 kg
25 kg
30 kg
35 kg
40 kg
45 kg
50 kg
55 kg
60 kg
65 kg
70 kg

Liposomal amphotericin B, 50 mg-vial in 12 ml

Daily dose
in mg/kg
12
15
18
21
24
27
30
45
60
75
90
105
120
135
150
165
180
195
210

Nb of vials

2
3
4
5

G5%

Volume of suspension
Volume required
(4 mg/ml) to be withdrawn for administration
3 ml
4 ml
4.5 ml
5 ml
6 ml
7 ml
7.5 ml
11 ml
15 ml
19 ml
23 ml
26 ml
30 ml
34 ml
38 ml
41 ml
45 ml
50 ml
53 ml

50 ml

250 ml

500 ml

159

Cutaneomucous or visceral leishmaniasis


Follow the recommended protocol, which varies from one region to another (exact dose,
administration schedule, etc.). For information, the total dose in children over 1 month and
adults is 15 to 30 mg/kg.

May cause:
intolerance reactions during administration: fever, chills, headache, nausea, vomiting,
hypotension; local reaction: pain and thrombophlebitis at injection site; allergic reactions;
gastrointestinal disturbances, disturbances in renal function (raised creatinine or urea
levels, renal impairment), hypokalaemia, hypomagnesiemia, elevated liver enzymes;
rarely, haematological disorders (thrombocytopenia, anaemia).
Avoid combination with: drugs causing hypokalaemia (furosemide, corticosteroids),
nephrotoxic drugs (amikacin, ciclosporine); digoxin, zidovudine.
The infusion may be administered over 2 hours if necessary to prevent or minimize adverse
effects.
Monitor serum creatinine levels, and if possible, serum potassium levels (once to twice
weekly) throughout treatment; adapt adjunctive therapy (potassium and magnesium
supplementation) according to the results.
If renal function deteriorates, reduce the dose by half for a few days.
Pregnancy: check for renal dysfunction in the newborn if administered during the last month of
pregnancy.
Breast-feeding: avoid, except if vital

Contra-indications, adverse effects, precautions

Liposomal amphotericin B is better tolerated and less nephrotoxic than conventional


amphotericin B.
Do not add other drugs in the infusion bottle or bag; do not use the preparation if there is
visible precipitation.
Before each infusion, rinse the IV catheter with 5% glucose.
Storage:
Vial of powder: must be kept refrigerated (between 2C and 8C) or below 25C.
Solutions (reconstituted and for infusion): be kept refrigerated 24 hours (between 2C and 8C).

Remarks

160

AMPICILLIN (Pentrexyl)
and AMOXICILLIN (Clamoxyl)

Prescription under medical supervision

Penicillin antibacterial

Therapeutic action

Severe infections: pneumonia, meningitis, septicaemia, endocarditis, puerperal fever,


pyelonephritis, etc., alone or in combination with other antibacterials, depending on indication,
only when oral administration is not possible

Indications

Powder for injection in 500 mg and 1 g vials, to be dissolved in water for injection, for IM
or slow IV injection (over 3 to 5 minutes) or infusion (over 20 to 30 minutes) in 0.9% sodium
chloride

Presentation and route of administration

The daily dose must be administered in at least 3 injections or infusions, at 8-hour intervals.
Injectable ampicillin and injectable amoxicillin are used at the same doses for the same
indications:
Child: 100 mg/kg/day in 3 injections or infusions
Adult: 3 to 4 g/day in 3 to 4 injections or infusions

Dosage

Age

< 1 year

1 to 5 years

5 to 10 years

10 to 15 years
Adults

Weight
< 8 kg

8 to 15 kg

500 mg vial
1 g vial
(to be dissolved in 5 ml) (to be dissolved in 5 ml)

15 to 25 kg
25 to 35 kg
> 35 kg

2 ml x 3

4 ml x 3

2 ml x 3
3 ml x 3

3/4

1 g vial

to 1 vial x 3

1 vial x 3

In the event of pyelonephritis or puerperal fever, increase dosage:


Child: 200 mg/kg/day in 3 injections or infusions
Adult: 8 g/day in 3 to 4 injections or infusions
In the event of meningitis, septicaemia and endocarditis:
Child: 200 mg/kg/day in 3 to 4 injections or infusions or as a continuous infusion
Adult: 12 g/day in 3 to 4 injections or infusions or as a continuous infusion

Duration: according to indication; change to oral treatment as soon as possible

Do not administer to penicillin-allergic patients, patients with infectious mononucleosis.


Administer with caution to patients allergic to cephalosporins (cross-sensitivity may
occur).
May cause: gastrointestinal disturbances, allergic reactions, sometimes severe. In the event
of allergic reaction, stop treatment immediately.
Reduce dosage in patients with severe renal impairment.
Do not combine with methotrexate.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Do not mix with another drug in the same in the same syringe or infusion.
Storage: below 30C
Ampicillin is stable for 12 hours in 0.9% sodium chloride and for 4 hours in 5% glucose.
Amoxicillin is stable for 6 hours in 0.9% sodium chloride and for 1 hour in 5% glucose.

Remarks

161

ARTEMETHER
(Paluther)

Prescription under medical supervision

Antimalarial

Therapeutic action
Treatment of severe falciparum malaria
Initial treatment of uncomplicated falciparum malaria, when persistent vomiting precludes
oral therapy

Indications

80 mg in 1 ml ampoule (80 mg/ml), oily solution for IM injection


20 mg in 1 ml ampoule (20 mg/ml), oily solution for IM injection
when the dose required is less than 1 ml, use a 1 ml syringe graduated in 0.01 ml.

Presentation and route of administration

Child and adult:


3.2 mg/kg by IM injection on the first day followed by 1.6 mg/kg once daily

Dosage and duration


Weight
< 3 kg

20 mg ampoule

Loading dose

3-4 kg
5-6 kg
7-9 kg

10-14 kg
15-19 kg
20-29 kg
30-39 kg
40-49 kg
50-59 kg

0.5 ml
0.8 ml
1.2 ml
1.6 ml
2.5 ml
3.2 ml

80 mg ampoule

Maintenance
dose

Loading dose

0.6 ml

0.3 ml
0.4 ml
0.8 ml
1.2 ml
1.6 ml

Maintenance
dose

1.2 ml

0.6 ml

2.5 ml

1.2 ml

1.6 ml
2 ml

0.8 ml
1 ml

As soon as the patient can swallow, change to oral route with an artemisinin-based
combination therapy (do not use the combination artesunate-mefloquine if the patient
developed neurological signs during the acute phase).
May cause: headache, gastrointestinal disturbances, dizziness, neutropenia and transient
increase in liver transaminases.
Do not administer by IV route.
Pregnancy: no contra-indication during the 2nd and 3rd trimester. The safety of artemether in the first
trimester has not yet been definitely established. However, given the risks associated with malaria,
artemether may be used during the first trimester if it is the only effective treatment available.
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Storage: below 30C

Remarks

162

ARTESUNATE
(Larinate, Artesun)
Prescription under medical supervision

Therapeutic action
Antimalarial

Indications

Treatment of severe falciparum malaria


Initial treatment of uncomplicated falciparum malaria, when persistent vomiting precludes
oral therapy

Presentation, preparation and route of administration

Powder for injection, 60 mg in vial, supplied with one 1 ml-ampoule of 5% sodium


bicarbonate and one 5 ml-ampoule of 0.9% sodium chloride, for slow IV injection (over 2 to
3 minutes) or slow IM injection
Dissolve the powder with 1 ml of 5% sodium bicarbonate, shake the vial until the solution
becomes clear. Then add to the vial:
5 ml of 0.9% sodium chloride to obtain 6 ml of solution containing 10 mg of artesunate
per ml, for IV injection
or
2 ml of 0.9% sodium chloride to obtain 3 ml of solution containing 20 mg of artesunate
per ml, for IM injection
Use a 1 ml syringe graduated in 0.01 ml when the dose required is less than 1 ml.

Dosage and duration

Child and adult: 2.4 mg/kg on admission then at 12 hours and 24 hours (H0, H12, H24)
then once daily
IV injection
Artesunate solution 10 mg/ml
Weight
Dose
< 3 kg
0.8 ml
3-4 kg
1.2 ml
5-7 kg
2 ml
8-11 kg
3 ml
12-16 kg
4 ml
17-23 kg
6 ml
24-30 kg
8 ml
31-40 kg
10 ml
41-50 kg
12 ml
51-60 kg
15 ml
61-70 kg
18 ml
> 70 kg
21 ml

IM injection
Artesunate solution 20 mg/ml
Weight
Dose
< 3 kg
0.4 ml
3-4 kg
0.6 ml
5-7 kg
1 ml
8-11 kg
1.5 ml
12-16 kg
2 ml
17-23 kg
3 ml
24-30 kg
4 ml
31-40 kg
5 ml
41-50 kg
6 ml
51-60 kg
7.5 ml
61-70 kg
9 ml
> 70 kg
10.5 ml

Administer at least three doses parenterally, then, if the patient can swallow, change to oral
route with an artemisinin-based combination (do not use the combination artesunatemefloquine if the patient developed neurological signs during the acute phase).

Contra-indications, adverse effects, precautions


May cause: fever, rarely rash, pruritus.
Pregnancy and breast-feeding: no contra-indication

Remarks

The solution should be clear, do not use if the solution is cloudy or if a precipitate is present.

Storage: below 25C


Once reconstituted, the solution should be used immediately.

163

ATROPINE
Prescription under medical supervision
Parasympatholytic, antispasmodic

Therapeutic action

Premedication in anaesthesia
Spasms of the gastrointestinal tract
Organophosphorus pesticide poisoning

Indications

1 mg atropine sulfate in 1 ml ampoule (1 mg/ml) for SC, IM, IV injection


Also comes in 0.25 mg/ml and 0.5 mg/ml ampoules.

Presentation and route of administration

Premedication in anaesthesia
Child: 0.01 to 0.02 mg/kg by SC or IV injection
Adult: 1 mg by SC or IV injection
Spasms of the gastrointestinal tract
Child from 2 to 6 years: 0.25 mg by SC injection as a single dose
Child over 6 years: 0.5 mg by SC injection as a single dose
Adult: 0.25 to 1 mg by SC injection, to be repeated every 6 hours if necessary, without
exceeding 2 mg/day.
Organophosphorus pesticide poisoning
Child: 0.02 to 0.05 mg/kg by IM or slow IV injection
Adult: 2 mg by IM or slow IV injection
Repeat every 5 to 10 minutes until signs of atropinisation appear (reduced secretions,
tachycardia, dilatation of the pupils).

Dosage

Do not administer to patients with urethro-prostatic disorders, cardiac disorders, glaucoma.


Do not administer to children with high fever.
May cause: urinary retention, dryness of the mouth, constipation, dizziness, headache,
dilatation of the pupils, tachycardia.
Administer with caution and under close supervision to patients taking other anticholinergic drugs (antidepressants, neuroleptics, H-1 antihistamines, antiparkinsonians, etc.).
Pregnancy: no contra-indication; NO PROLONGED TREATMENT
Breast-feeding: avoid; NO PROLONGED TREATMENT

Contra-indications, adverse effects, precautions

Atropine IV is also used to prevent bradycardic effects of neostigmine when used to reverse
the effects of competitive muscle relaxants: 0.02 mg/kg in children; 1 mg in adults.
Do not mix with other drugs in the same syringe.
Storage: below 30C

Remarks

164

BENZATHINE BENZYLPENICILLIN
(Extencilline, Penadur, Penidural, Penilevel Retard)

Prescription under medical supervision

Penicillin antibacterial with prolonged action (15 to 20 days)

Therapeutic action

Treatment of syphilis (except neurosyphilis)


Treatment of non-venereal treponematoses: bejel, yaws, pinta
Treatment of streptococcal tonsillitis
Prophylaxis of rheumatic fever
Treatment of diphtheria, prophylaxis of diphtheria in the event of direct contact

Indications

Powder for injection, 2.4 M Iu (= 1.44 g) vial, to be dissolved in 8 ml water for injection, for
IM injection. NEVER FOR IV INjECTION NOR INFuSION. Shake suspension before administration.
Also comes in 1.2 M Iu (= 0.72 g) vial to be dissolved in 4 ml and 0.6 M Iu (= 0.36 g) vial to
be dissolved in 2 ml.

Presentation and route of administration

Treatment of syphilis
Adult: 2.4 MIu/injection. For early syphilis: single dose; for late syphilis or syphilis of unknown
duration: one injection per week for 3 weeks. Divide the dose into 2 injections (half-dose in
each buttock).

Dosage and duration

Bejel, yaws, pinta, streptococcal tonsillitis, prophylaxis and treatment of diphtheria


Child under 30 kg: 600 000 Iu as a single dose
Child over 30 kg and adult: 1.2 MIu as a single dose

Prophylaxis of rheumatic fever


Child under 30 kg: 600 000 Iu
Child over 30 kg and adult: 1.2 MIu
For primary prophylaxis: administer a single dose; for secondary prophylaxis: one injection
every 3 to 4 weeks.
Do not administer to penicillin-allergic patients.
Administer with caution to patients allergic to cephalosporins (cross-sensitivity may occur).
May cause:
gastrointestinal disturbances; allergic reactions, sometimes severe. In the event of
allergic reactions, stop treatment immediately,
jarisch-Herxheimer reaction in patients with syphilis.
Ensure that the IM injection does not enter a blood vessel: IV administration may result in
cardiorespiratory arrest.
Do not combine with methotrexate.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Benzathine benzylpenicillin (or penicillin G benzathine) is a penicillin with a long duration


of action (15 to 20 days), this must not be confused with benzylpenicillin (or penicillin G)
that has a short duration of action (6 hours).
Benzathine benzylpenicillin should not be used for prevention, except in case of rheumatic
fever or diphtheria.
Do not mix with other drugs in the same syringe.
Storage: below 30C
Once reconstituted, suspension must be kept refrigerated (2C to 8C) and may be used for up to
24 hours.

Remarks

165

BENZYLPENICILLIN = PENICILLIN G
(Crystapen, Penilevel)
This presentation is rarely used as it requires
injections every 4 to 6 hours, which can only be
done in a hospital setting.

Prescription under medical supervision

Penicillin antibacterial with rapid action and elimination (6 hours)

Therapeutic action

Severe infections: pneumonia, neurosyphilis, meningitis, necrotising fasciitis, gas gangrene,


septicaemia, endocarditis, etc., alone or in combination with other antibacterials, depending
on indication

Indications

Powder for injection in 1 MIu (600 mg) and 5 MIu (3 g) vials, for IM or IV injection (via the
infusion tube) or infusion

Presentation and route of administration

Severe pneumonia
Child over 2 months: 200 000 to 400 000 Iu (120 to 240 mg)/kg/day in 4 injections
Adult: 8 to 12 MIu (4.8 to 7.2 g)/day in 4 injections
Neurosyphilis
Adult: 12 to 24 MIu (7.2 to 14.4 g)/day in 6 injections
Meningitis, streptococcal necrotising fasciitis, gas gangrene, anthrax
Child: 600 000 Iu (360 mg)/kg/day in 6 injections
Adult: 24 MIu (14.4 g)/day in 6 injections

Dosage

Pneumonia: 5 days minimum; neurosyphilis and meningococcal or pneumococcal meningitis:


14 days; fasciitis and gas gangrene: 7 days minimum; anthrax: 7 to 10 days

Duration

Do not administer to penicillin-allergic patients.


Administer with caution to patients allergic to cephalosporins (cross-sensitivity may occur).
May cause:
gastrointestinal disturbances, allergic reactions sometimes severe. In the event of allergic
reactions, stop treatment immediately,
jarisch-Herxheimer reaction in patients with syphilis (to be prevented with oral
prednisolone: 3 doses of 20 mg administered at 12 hour-intervals),
neurotoxicity in patients with renal impairment or when large doses are injected too
rapidly by IV route.
Reduce dosage in patients with severe renal impairment: maximum 10 MIu/day (6 g/day)
in adults.
Do not combine with methotrexate.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Do not confuse rapidly acting benzylpenicillin, which can be used by IV route, with longacting penicillins (procaine benzylpenicillin and benzathine benzylpenicillin), which must
never be used for IV injection or infusion.
Do not mix with other drugs in the same syringe or infusion.
Storage: below 30C
Once reconstituted, suspension must be used immediately.

Remarks

166

BENZYLPENICILLIN PROCAINE = PENICILLIN G PROCAINE


(Depocillin, Duracillin)

Prescription under medical supervision

Penicillin antibacterial with prolonged effect (12 to 24 hours)

Therapeutic action

Diphtheria, pneumonia, erysipelas and cellulitis, cutaneous anthrax


Neurosyphilis, in combination with probenecid

Indications

Powder for injection in 1 MIu (1 g) and 3 MIu (3 g) vials, to be dissolved in water for
injection, for IM injection. NEVER FOR IV INjECTION OR INFuSION.

Presentation and route of administration

Child: 50 000 Iu/kg (50 mg/kg) once daily, without exceeding 1.5 MIu
Adult: 1 to 1.5 MIu once daily (for neurosyphilis, 2.4 MIu once daily)

Dosage

Age

< 1 year

1 to 5 years

5 to 10 years

10 to 15 years
Adult

Weight
< 8 kg

8 to 15 kg

15 to 25 kg
25 to 35 kg
> 35 kg

1 MUI vial

1/4

to 1/2 vial

2/3

vial

1 vial
1 vial
1 vial

3 MUI vial
1/3
1/2
1/2

vial
vial
vial

Diphtheria: 7 days; pneumonia, anthrax, erysipelas, cellulitis: 7 to 10 days; neurosyphilis: 10 to


14 days

Duration

Do not administer to patients allergic to penicillin and/or procaine.


Administer with caution to patients allergic to cephalosporins (cross-sensitivity may occur).
Administer with caution to children under one year: risk of seizures and allergy due to
procaine.
May cause:
pain at the injection site, gastrointestinal disturbances, allergic reactions sometimes
severe. In the event of allergic reactions, stop treatment immediately.
jarisch-Herxheimer reaction in patients with syphilis (to be prevented with oral prednisolone: 3 doses of 20 mg administered at 12 hour-intervals).
Reduce dosage in patients with severe renal impairment.
Do not combine with methotrexate.
Ensure that the IM injection does not enter a blood vessel: IV administration may result in
ischemia at the injection site, psychiatric and neurological disorders (agitation, hallucinations, seizures).
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

For the treatment of neurosyphilis, benzylpenicillin procaine is combined with oral probenecid (2 g/day in 4 divided doses at 6-hour intervals) for the entire length of treatment.
Benzylpenicillin procaine is replaced in some countries by a combination of benzylpenicillin procaine (3 MIu) + benzylpenicillin (1 MIu), often called fortified penicillin
procaine (PPF) which has the advantage of the immediate action of benzylpenicillin,
followed by the delayed action of benzylpenicillin procaine.
Do not mix with other drugs in the same syringe.
Storage:
Once reconstituted, suspension must be used immediately.

Remarks

167

BENZYLPENICILLIN PROCAINE/ BENZYLPENICILLIN


= FORTIFIED PENICILLIN PROCAINE
(Bicillin)

Prescription under medical supervision

Penicillin antibacterial with both prolonged effect due to procaine benzylpenicillin (12 to
24 hours) and immediate effect due to benzylpenicillin

Therapeutic action

Diphtheria, pneumonia, erysipelas and cellulitis, cutaneous anthrax

Indications

Powder for injection in 3 MIu benzylpenicillin procaine + 1 MIu benzylpenicillin vial, to be


dissolved in 8 ml water for injection, for IM injection. NEVER FOR IV INjECTION OR INFuSION.

Presentation and route of administration

Child: 50 000 Iu/kg (50 mg/kg) once daily, without exceeding 1.5 MIu
Adult: 1 to 1.5 MIu once daily

Dosage

Age

Weight

3 MUI + 1 MUI vial


(to be dissolved in 8 ml)

1 to 5 years

8 to 15 kg

1.5 ml

< 1 year

< 8 kg

5 to 10 years

15 to 25 kg

Adult

> 35 kg

10 to 15 years

25 to 35 kg

0.75 ml
2.5 ml
3 ml
3 ml

Diphtheria: 7 days; pneumonia: 5 days minimum; anthrax, erysipelas, cellulitis: 7 to 10 days

Duration

Do not administer to patients allergic to penicillin and/or procaine.


Administer with caution to patients allergic to cephalosporins (cross-sensitivity may occur).
Administer with caution to children under one year: risk of seizures and allergy due to
procaine.
May cause: pain at the injection site, gastrointestinal disturbances, allergic reactions sometimes
severe. In the event of allergic reactions, stop treatment immediately.
Reduce dosage in patients with severe renal impairment.
Do not combine with methotrexate.
Ensure that the IM injection does not enter a blood vessel: IV administration may result in
ischemia at the injection site, psychiatric and neurological disorders (agitation, hallucinations,
seizures).
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Do not mix with other drugs in the same syringe.


Storage:
Once reconstituted, suspension must be used immediately.

Remarks

168

CALCIUM GLUCONATE
Prescription under medical supervision
Calcium therapy
Antidote to magnesium sulfate

Therapeutic action

Severe hypocalcaemia (hypocalcaemic tetany, neonatal hypocalcaemia, etc.)


Symptomatic hypermagnesaemia due to excessive doses of magnesium sulfate

Indications

1 g ampoule (100 mg/ml, 10 ml; 10% solution) for slow IV injection or infusion in 5%
glucose or 0.9% sodium chloride or Ringer lactate
Also comes in 5 g ampoule (100 mg/ml, 50 ml), 10 g vial (100 mg/ml, 100 ml), 20 g vial
(100 mg/ml, 200 ml).

Presentation and route of administration

Severe hypocalcaemia
Neonate: 2 ml/kg of a 10% solution by IV infusion over 30 minutes followed by 4 ml/kg of
a 10% solution administered by continuous infusion over 24 hours
Adult: 10 ml by slow IV injection (over at least 5 minutes), either repeated as required, or
followed by continuous infusion of 40 ml of a 10% solution over 24 hours
Change to oral route as soon as possible.
Magnesium sulfate intoxication
Adult: 10 ml of a 10% solution by slow IV injection (over at least 5 minutes), to be repeated
once if necessary

Dosage

Duration: according to clinical response and plasma-calcium levels

Do not administer to patients with severe renal disease or patients receiving cardiac
glycosides.
Do not administer by IM or SC route (pain and risk of tissue necrosis or abscess formation
at injection site, especially in infants and children).
May cause:
tingling sensations, warm flushes, dizziness,
tissue necrosis in the event of extravasation,
hypercalcaemia in the event of too rapid IV injection or overtreatment. First signs of
hypercalcaemia include nausea, vomiting, thirst and polyuria. In severe cases, hypotension, bradycardia, arrhythmia, syncope and cardiac arrest may develop.
Hypercalcaemia can be confirmed by monitoring of serum-calcium levels and ECG
changes. Do not use in prolonged treatment if plasma-calcium levels cannot be monitored.
The patient should be placed in the horizontal position prior to injection and should remain
lying down for 30 to 60 minutes.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Calcium gluconate is also administered as adjunctive therapy in insect bites or stings (black
widow spider, scorpions) for the management of muscle pain and spasms. Several doses at
4-h intervals may be necessary.
1 g of calcium gluconate (2.2 mmol or 4.5 mEq) is equivalent to 89 mg of calcium.
Calcium gluconate is incompatible with many drugs: do not mix with other drugs in the
same syringe or infusion fluid.
Do not use if a precipitate is present.
Storage: below 30C

Remarks

169

CEFTRIAXONE
(Rocephin)

Prescription under medical supervision

Third-generation cephalosporin antibacterial

Therapeutic action

Severe infections, e.g.: septicaemia, meningitis (except Listeria), typhoid fever, severe
pneumonia, acute mastoiditis, pyelonephritis, pelvic inflammatory disease, gonococcal
conjunctivitis

Indications

Powder for injection, in 250 mg or 1 g vial, supplied with a solvent containing lidocaine, for
IM injection only. DO NOT ADMINISTER By IV INjECTION OR INFuSION the solution reconstituted
with this solvent.
Powder for injection, in 250 mg or 1 g vial, to be dissolved in water for injection, for slow
IV injection (2 to 4 minutes) or infusion in 5% glucose or 0.9% sodium chloride (30 minutes)

Presentation and route of administration

Severe infections
Child > 1 month: 50 to 80 mg/kg once daily by IM or slow IV injection or infusion
(30 minutes); up to 100 mg/kg once daily in meningitis
Adult: 1 to 2 g (up to 4 g) once daily by IM (if necessary, administer half the dose into each
buttock) or slow IV injection or infusion (30 minutes)
Duration varies according to indication and clinical response.

Dosage and duration

Meningococcal meningitis in an epidemic context


Child 2 years and adult: 100 mg/kg IM as a single dose; maximum 4 g. If there is no
clinical improvement after 24 hours, administer a second dose.
Gonococcal conjunctivitis
Neonate: 50 mg/kg IM as a single dose; maximum 125 mg
Adult: 250 mg IM as a single dose

Do not administer to patients with allergy to cephalosporins; to neonates with jaundice


(risk of bilirubin encephalopathy).
Administer with caution to penicillin-allergic patients (cross-sensitivity in 0.5 to 6% of
patients).
May cause: gastrointestinal disturbances, allergic reactions sometimes severe (Stevensjohnson syndrome), hepatic dysfunction; rarely: pancreatitis, blood disorders (anaemia,
leucopenia, thrombocytopenia), renal dysfunction.
In the event of allergic reactions, stop treatment immediately.
Reduce dosage in patients with hepatic or renal impairment.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Ceftriaxone IM (250 mg as a single dose in adults) may be used for the treatment of gonorrhoea
and chancroid. However, cefixime PO is preferred for gonorrhoea and azithromycin PO for
chancroid.
Do not mix with other drugs in the same syringe or bottle; do not add to solutions containing
calcium (Ringer or Hartmann).
Storage: below 30C
Once reconstituted, solution keeps 6 hours at a temperature below 25C.

Remarks

170

Revised October 2014

CHLORAMPHENICOL

The use of chloramphenicol should be restricted to


severe infections when other less toxic antibacterials
are not effective or contra-indicated.

Prescription under medical supervision

Therapeutic action

Phenicol antibacterial

Indications

First-line treatment of plague meningitis


Alternative to first-line treatments of septicaemic plague
Severe cutaneous anthrax
Alternative to first-line treatments of typhoid fever, when oral administration is not
possible

Presentation and route of administration

1 g powder for injection, to be dissolved in 10 ml of water for injection, for IV injection over
1 to 2 minutes

Dosage

Child from 1 year to less than 13 years: 50 to 100 mg/kg/day in 3 divided injections
Child 13 years and adult: 3 g/day in 3 divided injections
Age

1 to < 2 years
2 to < 3 years
3 to < 6 years
6 to < 8 years

Duration

Weight

10 to < 13 kg
13 to < 15 kg
15 to < 20 kg
20 to < 25 kg

1 g vial (to
1 g vial (to
Age
Weight
be dissolved
be dissolved
in 10 ml)
in 10 ml)
3 ml x 3
8 to < 9 years
25 to < 30 kg
7 ml x 3
3.5 ml x 3
9 to < 11 years
30 to < 35 kg
8 ml x 3
5 ml x 3
11 to < 13 years 35 to < 45 kg
9 ml x 3
6 ml x 3 13 years and adult
45 kg
10 ml x 3

Plague and cutaneous anthrax: 10 days; typhoid fever: 10 to 14 days. Change to oral route as
soon as possible.

Contra-indications, adverse effects, precautions

Do not administer to children under 1 year.


Do not administer to patients with:
history of allergic reaction or bone marrow depression during a previous treatment with
chloramphenicol;
G6PD deficiency.
May cause:
dose-related haematological toxicity (bone marrow depression, anaemia, leucopenia,
thrombocytopenia), allergic reactions. In these events, stop treatment immediately.
gastrointestinal disturbances, peripheral and optic neuropathies.
Reduce dosage in patients with hepatic or renal impairment.
Avoid or monitor combination with potentially haematotoxic drugs (carbamazepine,
cotrimoxazole, flucytocine, pyrimethamine, zidovudine, etc.).
Pregnancy: CONTRA-INDICATED, except if vital, if there is no therapeutic alternative. If used during
the 3rd trimester, risk of grey syndrome in the newborn infant (vomiting, hypothermia, blue-grey
skin colour and cardiovascular depression).
Breast-feeding: CONTRA-INDICATED

Remarks

Oral treatment is more effective than parenteral treatment: blood and tissue concentrations
are higher when chloramphenicol is given orally.
Storage: below 25C

171

Revised October 2014

Long-acting oily CHLORAMPHENICOL

Ceftriaxone should be preferred to oily chloramphenicol, as it is more effective and less toxic.

Prescription under medical supervision

Therapeutic action

Phenicol antibacterial, with prolonged effect

Indications

Treatment of meningococcal meningitis during epidemics

Presentation and route of administration

500 mg oily suspension in 2 ml ampoule (250 mg/ml) for IM injection only. NEVER FOR IV
INJECTION.

Dosage

Child over 2 years and adult: 100 mg/kg as a single dose (max. 3 g/dose)
Age

Weight

Dose

Volume

31 to < 54 kg

2.5 g

10 ml

2 to < 6 years

13 to < 21 kg

15 years and adult

54 kg

6 to < 10 years

10 to < 15 years

21 to < 31 kg

1.5 g
2g

3g

If necessary, administer half the dose into each buttock.

6 ml

8 ml

12 ml

Duration

Single dose. If there is no improvement after 24 hours, a second dose may be administered.

Contra-indications, adverse effects, precautions

Do not administer to patients with:


history of allergic reaction or bone marrow depression during a previous treatment with
chloramphenicol;
G6PD deficiency.
May cause:
dose-related haematological toxicity (bone marrow depression, anaemia, leucopenia,
thrombocytopenia), allergic reactions. In these events, stop treatment immediately.
gastrointestinal disturbances, peripheral and optic neuropathies.
Avoid or monitor combination with potentially haematotoxic drugs (carbamazepine,
cotrimoxazole, flucytocine, pyrimethamine, zidovudine, etc.).
Pregnancy: CONTRA-INDICATED
Breast-feeding: CONTRA-INDICATED

Remarks

Oily chloramphenicol is not recommended as chemoprophylaxis for meningitis contacts


during epidemics. All suspected cases must be examined at the first signs of the disease.
Shake the injection suspension before administration.
Storage: below 25C

172

CHLORPROMAZINE
(Largactil)

Prescription under medical supervision

Sedative antipsychotic (neuroleptic)

Therapeutic action

Agitation or aggressive behaviour in patients with acute or chronic psychosis

Indications

50 mg in 2 ml ampoule (25 mg/ml) for IM injection

Presentation and route of administration

Adult: 25 to 50 mg by IM injection. A second dose may be administered if necessary after


at least an hour.
Subsequent doses, if needed, should be given at 6 to 8 hour intervals (max. 150 mg/day).
Administer one-quarter of the usual dose in elderly patients.

Dosage

Duration: change to oral treatment as soon as possible

Do not administer to patients with closed-angle glaucoma, prostate disorders; to elderly


patients with dementia (e.g. Alzheimer's disease).
Administer with caution and carefully monitor use in patients > 60 years; patients with
epilepsy, chronic constipation, renal or hepatic impairment, Parkinson's disease, myasthenia
gravis.
May cause:
orthostatic hypotension (keep the patient in the supine position for 30 minutes after
injection);
anticholinergic effects (dry mouth, blurred vision, urinary retention, constipation,
tachycardia);
extrapyramidal syndrome, dyskinesia, photosensibilisation; neuroleptic malignant
syndrome (unexplained hyperthermia with neuromuscular disorders), rare but requiring
immediate treatment discontinuation.
Avoid combination with: drugs which lower the seizure threshold (mefloquine, chloroquine,
tramadol, tricyclic or SSRI antidepressants); CNS depressants (opioid analgesics, sedatives,
H1 antihistamines, etc.); drugs known to have anticholinergic effects (amitriptyline, atropine,
carbamazepine, clomipramine, promethazine, etc.); antidiabetics, lithium.
Pregnancy: avoid (risk of maternal hypotension)
Breast-feeding: avoid

Contra-indications, adverse effects, precautions

Avoid contact with skin (contact dermatitis reported in nursing personnel).


Storage: no special temperature requirements

Remarks

173

CLINDAMYCIN
(Dalacin)

Prescription under medical supervision

Lincosamide antibacterial

Therapeutic action

Second-line treatment of pneumocystosis, in combination with primaquine


Second-line treatment of cerebral toxoplasmosis, in combination with pyrimethamine

Indications

300 mg ampoule (150 mg/ml, 2 ml), to be diluted in 5% glucose or 0.9% sodium chloride
or Ringer Lactate, for infusion only. NEVER FOR IV INjECTION.

Presentation and route of administration

Adult: 2400 mg/day in 4 divided doses administered at 6-hour intervals

Dosage

Change to oral route as soon as possible. The total duration of treatment is 21 days for
pneumocystosis and 6 weeks for toxoplasmosis.

Duration

Do not administer to patients with allergy to lincosamides or history of pseudomembranous colitis.


May cause: diarrhoea (including severe: pseudomembranous colitis), nausea, rash, jaundice;
allergic reactions sometimes severe.
In the event of allergic reactions, stop treatment immediately. If pseudomembranous colitis
develops (mucus and false membranes), stop clindamycin and treat for C. difficile disease
(oral metronidazole).
Do not combine with: erythromycin and neuromuscular blocking drugs.
Reduce dosage in patients with hepatic impairment.
Pregnancy: no contra-indication
Breast-feeding: administer only if there is no therapeutic alternative. Check infant's stools (risk of
colitis).

Contra-indications, adverse effects, precautions

Do not mix with other drugs in the same infusion bottle.


Storage: below 30C

Remarks

174

CLOXACILLIN
(Cloxapen, Orbenin)

Prescription under medical supervision

Penicillin antibacterial active against penicillinase-producing staphylococci

Therapeutic action

Severe infections due to staphylococci resistant to penicillin: meningitis, staphylococcal


pneumonia, pyomyositis, septicaemia, endocarditis, etc.

Indications

Powder for injection, 500 mg vial, for infusion (over 60 minutes) in 5% glucose or 0.9%
sodium chloride
Also comes in 250 mg and 1 g vials.

Presentation and route of administration

Child: 100 to 200 mg/kg/day in 4 divided doses (max. 12 g/day)


Adult: 8 to 12 g/day in 4 to 6 divided doses

Dosage

Age

< 3 months

3 to 11 months

weight
< 6 kg

6 to 9 kg

1 to 5 years

10 to 19 kg

13 to 15 years

38 to 55 kg

6 to 8 years

9 to 12 years
Adult

20 to 27 kg
28 to 37 kg
> 55 kg

250 mg vial
1/2

vial x 4

1 vial x 4

2 vials x 4

500 mg vial
1/4
1/2

vial x 4
vial x 4

1 vial x 4

2 vials x 4
3 vials x 4
4 vials x 4

4 vials x 4 to 6

1 g vial

1 vial x 4

11/2 vial x 4
2 vials x 4

2 vials x 4 to 6

Depending on indication

Duration

Do not administer to penicillin-allergic patients.


Administer with caution to patients allergic to cephalosporins (cross-sensitivity may
occur); in neonates (risk of hyperbilirubinemia).
May cause: gastrointestinal disturbances, allergic reactions sometimes severe; rarely,
haematological disorders. In the event of allergic reactions, stop treatment immediately.
Reduce the dose by half in patients with renal impairment.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Dicloxacillin (Diclocil, etc.), flucloxacillin (Floxapen, etc.) and oxacillin (Bristopen,


etc.) are used for the same indications.
Do not mix with other drugs in the same syringe or infusion.
Storage: below 25C
Reconstituted solution must be used immediately.

Remarks

175

DEXAMETHASONE
Prescription under medical supervision
Corticosteroid

Therapeutic action

Inflammatory syndrome in severe infections: severe typhoid fever, acute subglottic


laryngitis, etc.
Foetal lung maturation, in the event of threatened premature delivery before 34 weeks of
gestation

Indications

4 mg dexamethasone phosphate in 1 ml ampoule (4 mg/ml) for IM or IV injection or


infusion

Presentation and route of administration

Inflammatory syndrome in severe infections


Dosage and duration vary according to severity and clinical response:
Child: 0.2 to 0.4 mg/kg/day
Adult: initial dose of 0.5 to 24 mg/day

Dosage and duration

Foetal lung maturation


Administer to the mother: 6 mg by IM injection every 12 hours for 2 days (total dose: 24 mg)
For systemic infections, only administer if patient is under antibiotic treatment.
In the event of treatment longer than 10 days, decrease doses gradually to avoid adrenal
gland failure.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Foetal lung maturation:


after 34 weeks of gestation, corticosteroid treatment is not indicated;
dexamethasone may be replaced by betamethasone (Betnesol): 2 doses of 12 mg by IM
injection at 24-hour interval (total dose: 24 mg).
For allergic reactions (Quinkes oedema, anaphylactic shock) and status asthmaticus, use
hydrocortisone.
Dexamethasone acetate (Dectancyl), insoluble in water, is a suspension used only for local
treatment: intra-articular or peri-articular injection, epidural injection (sciatica).
Storage: below 25C
The solution precipitates at 0C, it must not be exposed to cold temperatures.

Remarks

176

DIAZEPAM
(Valium)
Use IV route only if technical equipment for ventilation
is available at hand.

Prescription under medical supervision

Anxiolytic, sedative, anticonvulsant, muscle relaxant

Therapeutic action

Seizures
Tetanus
Agitation associated with anxiety or confusion (delirium tremens), when oral administration
is not possible

Indications

10 mg ampoule (5 mg/ml, 2 ml) for IM or very slow IV injection or infusion


Injectable solution may be used by oral and rectal route.
For rectal or IV administration, dilute 2 ml (10 mg) of diazepam in 8 ml of 5% glucose or
0.9% sodium chloride.
For rectal administration, use a syringe without a needle, or better, cut a nasogastric tube,
CH8, to a length of 2-3 cm and attach it to the tip of the syringe.

Presentation and route of administration

Seizures
Child: 0.5 mg/kg rectally or 0.3 mg/kg by slow IV injection, without exceeding 10 mg
Adult: 10 mg rectally or by slow IV injection
If seizures do not stop within 5 minutes after the first dose, repeat once.
Tetanus
The dosage range is variable, depending on severity. For information:
Child and adult: 0.1 to 0.3 mg/kg by slow IV injection, to be repeated every 1 to 4 hours,
under close medical supervision
Agitation, delirium tremens
Adult: 5 to 10 mg by IM injection, to be repeated after one hour if necessary

Dosage and duration

Do not administer to patients with severe respiratory insufficiency or severe hepatic


impairment.
May cause:
pain at the IV or IM injection site,
hypotension, respiratory depression, particularly if administered IV, if injected too
rapidly by IV route and if large doses are administered (tetanus),
in the event overdose: hypotonia, lethargy, respiratory distress, coma.
Reduce the dose by one half in elderly patients and patients with renal or hepatic impairment.
Risk of increased sedation when combined with alcohol and drugs acting on the central
nervous system: opioid analgesics, neuroleptics (chlorpromazine, haloperidol, etc.), antihistamines (chlorphenamine, promethazine), antidepressants (clomipramine, fluoxetine,
etc.), phenobarbital, etc.
Pregnancy: avoid if possible, except if vital
Breast-feeding: avoid

Contra-indications, adverse effects, precautions

Diazepam is subject to international controls: follow national regulations.


Diluted solution is normally cloudy.
Do not mix with other drugs in the same syringe or infusion.
Storage: below 30C

Remarks

177

DICLOFENAC
(Cataflam, Voltaren, Voltarol)

Prescription under medical supervision

Non-steroidal anti-inflammatory drug, analgesic, antipyretic

Therapeutic action

Moderate pain, particularly due to inflammation (acute sciatic neuralgia, renal colic, postoperative pain etc.)

Indications

75 mg in 3 ml ampoule (25 mg/ml) for deep IM injection or infusion

Presentation and route of administration

Adult : 75 mg by deep IM injection; combine with 50 mg by oral route if necessary


For postoperative pain, may be administered by infusion: 75 mg over 30 to 120 minutes; to
be repeated after 4 to 6 hours if necessary.
Maximum dose: 150 mg/day

Dosage

Duration: maximum 2 to 3 days; change to oral treatment as soon as possible.

Do not administer in case of:


renal impairment, uncorrected dehydration or hypovolaemia, severe malnutrition,
peptic ulcer,
hypersensitivity to other NSAID (aspirin, ibuprofen, indometacin etc.), hepatic impairment, severe infection,
coagulation defects, surgery with risk of major blood loss.
May cause: renal impairment, gastrointestinal disturbances, allergic reactions (rash,
eczema, bronchospasm).
Administer with caution to elderly or asthmatic patients.
Do not combine with other NSAID (aspirin, ibuprofen, indometacin etc.), diuretics, anticoagulants.
Pregnancy: CONTRA-INDICATED
Breast-feeding: CONTRA-INDICATED

Contra-indications, adverse effects, precautions

For infusion, use a solution of 5% glucose or 0.9% sodium chloride and add 0.5 ml of 8.4%
sodium bicarbonate per 500 ml.
Diclofenac is not included in the wHO list of essential medicines.
Storage: below 30C

Remarks

178

DIGOXIN
(Coragoxine, Lanoxin)

Prescription under medical supervision

Cardiotonic

Therapeutic action
Supraventricular arrhythmias (fibrillation, flutter, paroxysmal tachycardia)
Heart failure

Indications

500 g ampoule (250 g/ml, 2 ml) for slow IV injection or infusion in 5% glucose or 0.9%
sodium chloride

Presentation and route of administration

Adult:
loading dose: 500 to 1000 g
The loading dose can be administered either by intravenous infusion as a single dose
given over 2 hours minimum or in divided doses, by slow IV injections over 5 minutes
minimum.
maintenance dose: change to oral treatment

Dosage

Reduce the dose by one half in elderly patients and in patients with renal impairment.

Do not administer to patients with bradycardia, ill defined arrhythmia, coronary artery
disease.
It is essential to monitor pulse in the initial stage of treatment.
Narrow margin between therapeutic and toxic dose.
May cause in the event of overdose: gastrointestinal disturbances (nausea, vomiting,
diarrhoea), blurred vision, headache, confusion, conduction and rhythm disorders. If so,
reduce dose or stop treatment.
Do not combine with calcium, particularly by IV route (serious arrhythmias).
Monitor combination with:
amiodarone, macrolides, itraconazole, quinine, chloroquine (increased digoxin concentration),
potassium-depleting drugs: diuretics, corticoids, amphotericin B (increased risk of
digoxin toxicity).
Monitor if possible serum potassium level in patients taking potassium-depleting drugs
and serum creatinine level in patients with renal impairment.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

A loading dose may be administered in arrhythmias if a rapid digitalisation is required. It


is usually not required for heart failure.
Storage: below 30C

Remarks

179

EFLORNITHINE
(Ornidyl)

Prescription under medical supervision

Trypanocide

Therapeutic action
Meningoencephalitic stage of African trypanosomiasis due to T.b. gambiense, in combination
with nifurtimox (first choice treatment) or in monotherapy if nifurtimox is not available or
is contra-indicated

Indications

20 g in 100 ml ampoule (200 mg/ml) to be diluted in 250 ml of sterile distilled water (or, if
not available, 0.9% sodium chloride), for IV infusion administered over 2 hours

Presentation and route of administration

In combination with nifurtimox


Child and adult: 400 mg/kg/day in 2 divided infusions administered at 12-hour intervals
for 7 days

Dosage and duration

In monotherapy
Child under 12 years: 600 mg/kg/day in 4 divided infusions administered at 6-hour
intervals for 14 days
Adult: 400 mg/kg/day in 4 divided infusions administered at 6-hour intervals for 14 days
May cause: haematological disorders (anaemia, leucopenia, thrombocytopenia), gastrointestinal disturbances (diarrhoea, abdominal pain, vomiting), seizures, tremor, fever, deep
tissue infection, headache, alopecia, dizziness.
The catheter must be handled with great attention to avoid local or general bacterial superinfections: thoroughly disinfect the insertion site, protect the site with a sterile dressing,
ensure secure catheter fixation and change the catheter every 48 hours or earlier in the
event of phlebitis.
Pregnancy: CONTRA-INDICATED unless, due to the mothers general condition, treatment cannot be
delayed until after delivery

Contra-indications, adverse effects, precautions

when administering nifurtimox-eflornithine combined therapy, the dosage of nifurtimox


in children and adults is 15 mg/kg/day in 3 divided doses at 8-hour intervals.
Eflornithine is also called difluoromethylornithine or DFMO.
Storage: below 30C
Diluted solution must be kept refrigerated (2C to 8C) and used within 24 hours.

Remarks

180

EPINEPHRINE = EPN = ADRENALINE


Prescription under medical supervision
Sympathomimetic

Therapeutic action

Severe anaphylactic reaction


Cardiopulmonary arrest

Indications

1 mg in 1 ml ampoule (1 mg/ml = 1:1000 solution) for IM injection, or for IV injection after


dilution in 0.9% sodium chloride to obtain a solution containing 0.1 mg/ml (1:10 000 solution)
Also comes in 0.1 mg/ml (1:10 000 solution) ampoules.
Before administration, check concentration and route of administration indicated on the
ampoule.

Presentation and route of administration

Severe anaphylactic reaction


IM epinephrine is the first line treatment (anterolateral part of the thigh), however use IV
epinephrine in patients with circulatory collapse or those who deteriorate despite receiving
IM epinephrine.

Dosage

IM treatment
use undiluted solution (1 mg/ml = 1:1000) and a 1 ml syringe graduated in 0.01 ml:
- Child under 6 years:
0.15 ml
- Child from 6 to 12 years:
0.3 ml
- Child over 12 years and adult: 0.5 ml
In children, if 1 ml syringe is not available, use a diluted solution, i.e. add 1 mg EPN to
9 ml of 0.9% sodium chloride to obtain a 0.1 mg/ml solution (1:10 000):
- Child under 6 years:
1.5 ml
- Child from 6 to 12 years:
3 ml
Repeat after 5 minutes if there is no clinical improvement.

IV treatment
use a diluted solution, i.e. add 1 mg EPN to 9 ml of 0.9% sodium chloride to obtain a
0.1 mg/ml solution (1:10 000):
- Child: 0.1 ml/kg (0.01 mg/kg) administered over several minutes
- Adult: 1 to 2 ml (0.1 to 0.2 mg), to be repeated every 1 to 2 minutes, until improvement
occurs

Cardiopulmonary arrest
use a diluted solution by IV route, i.e. add 1 mg EPN to 9 ml of 0.9% sodium chloride to
obtain a 0.1 mg/ml solution (1:10 000):
- Child: 0.1 ml/kg (0.01 mg/kg), to be repeated every 3 to 5 minutes, until improvement
occurs
- Adult: 10 ml (1 mg), to be repeated every 3 to 5 minutes, until improvement occurs
Administer with caution to patients with hypertension, angina, ischaemic heart disease,
hyperthyroidism and to elderly patients.
Do not exceed indicated dose: risk of arrhythmia.
Pregnancy and breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Epinephrine is colourless; discard any ampoules with a pink or brownish colour.


Storage:

Remarks

181

Revised February 2015

ETONOGESTREL subdermal implant

Therapeutic action

Prescription under medical supervision

Hormonal contraceptive, progestogen

Indications

Long-term hormonal contraception

Presentation and route of administration

Flexible rod containing 68 mg of etonogestrel, in a sterile disposable applicator, to be


inserted subdermally into the inner side of the non-dominant arm, 6 to 8 cm above the
elbow crease, under local anaesthesia and aseptic conditions

Dosage

If no current contraception, the implant is inserted:


during the first 7 days of menstruation or immediately after abortion
after childbirth: as of the 4th week postpartum if the woman breastfeeds or as of the
21st day postpartum if the woman does not breastfeed
When switching from another contraceptive method, the implant is inserted:
for an oral estroprogestogen: the day after taking the last active tablet in the pack
for an oral progestogen: at any stage of the cycle
for an injectable progestogen: the day the next injection is due
for an intrauterine device or another implant: the day of its removal
However, if there is a risk that the woman may be lost to follow-up, the implant may be
inserted as soon as the opportunity occurs, including before the timing proposed. If the
implant is inserted later (in the absence of pregnancy), it is recommended to use condoms
during the first 7 days after the insertion.

Duration

As long as contraception is desired and it is well tolerated, for max. 3 years (2 years in obese
women) after which it no longer provides contraception and must be changed.

Contra-indications, adverse effects, precautions

Do not administer to patients with breast cancer, severe or recent liver disease, unexplained
vaginal bleeding, current thromboembolic disorders.
May cause: menstrual irregularities, amenorrhoea, menometrorrhagia, breast tenderness,
headache, weight gain, itching, acne, mood changes, abdominal pain, gastrointestinal
disturbances, allergic reactions.
Hepatic enzyme inducers (rifampicin, rifabutin, nevirapine, nelfinavir, ritonavir,
phenobarbital, phenytoin, carbamazepine, griseofulvin, etc.) may reduce the contraceptive
efficacy. Use a copper intrauterine device or condoms or injectable medroxyprogesterone
or an oral contraceptive containing 50 micrograms ethinylestradiol (however there is still a
risk of oral contraceptive failure and the risk of adverse effects is increased).
Pregnancy: CONTRA-INDICATED
Breast-feeding: it is recommended to wait 4 weeks after childbirth before inserting the implant.

Remarks

Implants provide long term contraception, their efficacy is not conditioned by observance.
Fertility returns rapidly after removal of the implant.
For the conditions for insertion or removal the implant, follow manufacturers instructions.
Storage: below 25C

182

FLUCONAZOLE
(Triflucan)

Prescription under medical supervision

Antifungal

Therapeutic action
Severe fungal infections, when oral administration is not possible:
Cryptococcal meningitis, in combination with amphotericin B
Severe oesophageal candidiasis

Indications

200 mg in 100 ml bag (2 mg/ml), for infusion

Presentation and route of administration

Cryptococcal meningitis, in combination with amphotericin B


Child over 1 week: 12 mg/kg/once daily (max. 800 mg/day) administered over 20 minutes
minimum (max. 5 ml/minute)
Adult: 800 mg once daily, administered over 10 minutes minimum (max. 10 ml/minute)

Dosage

Severe oesophageal candidiasis


Child over 1 week: 3 to 6 mg/kg once daily
Adult: 200 mg once daily
These doses may be increased up to 400 mg/day if necessary.
Change to oral treatment as soon as possible.

Duration

Administer with caution to patients with hepatic or renal impairment, cardiac disorders
(bradycardia, heart rhythm disorders, etc.).
Reduce the dose by half in patients with renal impairment.
May cause: gastrointestinal disturbances, headache, skin reactions sometimes severe,
anaphylactic reactions; severe hepatic disorders, haematological (leukopenia, thrombocytopenia) and cardiac disorders (QT-prolongation). Stop treatment in the event of
anaphylactic reaction, hepatic disorders or severe skin reaction.
Avoid or monitor combination with:
drugs that prolong the QT interval (amiodarone, chloroquine, erythromycin, haloperidol,
mefloquine, pentamidine, quinine);
warfarin, carbamazepine, phenytoin, rifabutin, benzodiazepines, calcium-channel
blockers, certain antiretrovirals (e.g. nevirapine, saquinavir, zidovudine): increased blood
concentration of these drugs.

Contra-indications, adverse effects, precautions

For cryptococcocal meningitis, when amphotericin B is not available or not tolerated,


fluconazole may be administered alone during the induction phase (same doses as the oral
route).
Do not add any drug in the infusion bag.
Storage: no special temperature requirements. Do not store in a refrigerator.

Remarks

183

FUROSEMIDE = FRUSEMIDE
(Lasilix, Lasix, Seguril)

Prescription under medical supervision

Diuretic

Therapeutic action
Emergency treatment of:
Oedema caused by renal, hepatic or congestive heart failure
Hypertensive crisis (except that of pregnancy)
Pulmonary oedema

Indications

20 mg in 2 ml ampoule (10 mg/ml) for IM or slow IV injection

Presentation and route of administration


Child: 0.5 to 1 mg/kg/injection
Adult: 20 to 40 mg/injection

Dosage
AGE

WEIGHT
10 mg/ml ampoule

2
months

0.2 ml

4
kg

1
year
0.3 ml

8
kg

5
years
0.75 ml

15
kg

15
years
1.5 ml

Repeat after 2 hours if necessary

35
kg

ADULT

2 to 4 ml

For pulmonary oedema: if an initial IV injection of 40 mg does not produce a satisfactory response within one hour, the dose may be increased to 80 mg by slow IV injection.
According to clinical response;
If prolonged use is required, change to oral treatment 3 hours after the last injection.

Duration

Do not administer in other types of oedema, especially those due to kwashiorkor.


Do not administer in case of hepatic encephalopathy.
May cause: hypokalaemia, especially in cases of cirrhosis, denutrition, congestive heart
failure.
Closely monitor combination with digoxin (furosemide enhances toxicity of digoxin).
Pregnancy: CONTRA-INDICATED to treat hypertension in pregnancy
Breast-feeding: avoid (excreted in milk and may reduce milk production)

Contra-indications, adverse effects, precautions

If doses greater than 50 mg are required, it is recommended that they be given by IV infusion.
Storage: below 30C

Remarks

184

Revised November 2013

GENTAMICIN
(Genticin)

Prescription under medical supervision

Therapeutic action

Aminoglycoside antibacterial

Indications

Severe infections (endocarditis, septicaemia, peritonitis, pyelonephritis, etc.), in combination


with another antibacterial

Presentation and route of administration

20 mg ampoule (10 mg/ml, 2 ml) and 80 mg ampoule (40 mg/ml, 2 ml) for IM or slow IV
injection (over 15 minutes) or infusion (over 30 to 60 minutes)
Also comes in 10 mg ampoule (10 mg/ml, 1 ml), 40 mg ampoule (40 mg/ml, 1 ml), 40 mg
ampoule (20 mg/ml, 2 ml) and 160 mg ampoule (80 mg/ml, 2 ml).

Dosage

Child and adult: 3 to 6 mg/kg/day


The daily dose in usually administered in 2 injections. For treatments shorter than 7 days,
the daily dose may be given in a single injection.

AGE

WEIGHT

20 mg ampoule
(10 mg/ml, 2 ml)
40 mg ampoule
(20 mg/ml, 2 ml)
80 mg ampoule
(40 mg/ml, 2 ml)
160 mg ampoule
(80 mg/ml, 2 ml)

2
months

1 ml x 2

4
kg

1
year

1.5 ml x 2

0.5 ml x 2

0.75 ml x 2

0.2 ml x 2

8
kg

0.4 ml x 2

5
years

3 ml x 2

15
kg

1.5 ml x 2

0.75 ml x 2
0.4 ml x 2

15
years

3 ml x 2

1.5 ml x 2

0.75 ml x 2

35
kg

ADULT

3 ml x 2

1.5 ml x 2

Duration

According to indication and clinical response. Given the risk of renal and auditory toxicity,
do not prolong treatment unnecessarily.

Contra-indications, adverse effects, precautions

Do not administer to patients with allergy to gentamicin or another aminoglycoside.


Administer with caution to patients with renal impairment, auditory and vestibular damage;
reduce dosage in patients with renal impairment (1 mg/kg/day).
May cause: renal impairment, auditory and vestibular damage, allergic reactions.
Do not combine with another aminoglycoside.
Monitor combination with: neuromuscular blockers, general anaesthetics (potentialization
of their effects); amphotericin B, vancomycin, capreomycin, furosemide (enhanced renal
and/or auditory toxicity).
Pregnancy: avoid
Breast-feeding: no contra-indication

Remarks

Do not mix with other drugs in the same syringe or infusion.


Storage: below 30C

185

GLUCOSE 50% = DEXTROSE 50%


Prescription under medical supervision
Emergency treatment of severe hypoglycaemia

Indications

50% hypertonic glucose solution in 50 ml vial (500 mg/ml), for slow IV injection. NEVER By
IM OR SC INjECTION.

Presentation and route of administration

Adult: 1 ml/kg by very slow IV injection (over 5 minutes)


Check blood glucose level 30 minutes after injection. If blood glucose level is still
< 3 mmol/l or < 55 mg/dl, administer a second dose or give oral glucose, according to the
patient clinical condition.

Dosage and duration

May cause:
vein irritation,
severe tissue damage (necrosis) in the event of extravasation.
The solution is viscous: use a large vein and a large calibre needle.

Contra-indications, adverse effects, precautions

50% glucose solution is too viscous, concentrated and irritant to be used in children.
In children use 10% glucose solution. If ready-made 10% glucose solution is not available:
add 10 ml of 50% glucose per 100 ml of 5% glucose to obtain a 10% glucose solution. The
dose of 10% glucose to be administered is 5 ml/kg by very slow IV injection (over
5 minutes) or IV infusion.
Storage: below 30C

Remarks

186

HALOPERIDOL
(Haldol, Serenace)

Prescription under medical supervision

Antipsychotic (neuroleptic)

Therapeutic action

Agitation or aggressive behaviour in patients with acute or chronic psychosis

Indications

5 mg in 1 ml ampoule (5 mg/ml) for IM injection

Presentation and route of administration

Adult: 5 mg by IM injection
The total dose should not exceed 15 mg in 24 hours, with an interval of 2 to 8 hours between each dose.

Dosage

Duration: change to oral treatment as soon as possible

Do not administer to patients with cardiac disorders (cardiac failure, recent myocardial
infarction, conduction disorders, bradycardia, etc.); to elderly patients with dementia (e.g.
Alzheimer's disease).
Administer with caution and carefully monitor use in patients > 60 years and patients with
hypokalaemia, hyperthyroidism, renal or hepatic impairment, Parkinson's disease.
May cause: drowsiness, orthostatic hypotension (keep the patient in the supine position for
30 minutes after injection), extrapyramidal syndrome, dyskinesia, ventricular arrhythmia;
neuroleptic malignant syndrome (unexplained hyperthermia with neuromuscular
disorders), rare but requiring immediate treatment discontinuation.
Avoid combination with: carbamazepine, rifampicin, fluoxetine, lithium, drugs that
prolong the QT interval (amiodarone, chloroquine, erythromycin, fluconazole, mefloquine,
pentamidine, quinine).
Pregnancy: no contraindication
Breast-feeding: avoid; if absolutely necessary, do not exceed 5 mg in 24 hours.

Contra-indications, adverse effects, precautions

Haloperidol decanoate is a long-acting form used in the long-term management of


psychotic disorders in patients stabilised on oral treatment (100 mg every 3 to 4 weeks).
Storage: below 25C

Remarks

187

HEPARIN
Prescription under medical supervision

Anticoagulant
By IV injection: acts immediately for about 2 to 4 hours
By SC injection: acts within 1 hour for about 8 to 12 hours

Therapeutic action

Venous and arterial thrombosis: pulmonary embolism, myocardial infarction, thrombophlebitis


Prevention of venous and arterial thrombosis, especially in pre-operative and postoperative
period and in patients on bedrest
Prescription of heparin requires systematic monitoring of coagulation parameters.

Indications

1000 Iu in 1 ml ampoule (1000 Iu/ml) and 5000 Iu in 1 ml ampoule (5000 Iu/ml) for IV
injection or infusion, diluted in an isotonic solution of glucose or sodium chloride
25 000 Iu in 1 ml ampoule (25 000 Iu/ml) for SC injection
Also comes in various concentrations (500 Iu, 12 500 Iu, 20 000 Iu/ml) and volumes (0.5 ml,
2 ml, 5 ml). Check label before use.

Presentation and route of administration

Curative treatment
By IV route
Child and adult: initial dose of 50 to 100 Iu/kg followed by 400 to 600 Iu/kg/day, by
continuous infusion over 24 hours or by IV injection every 2 to 4 hours. Adjust dosage
according to coagulation tests.
By SC route
Child and adult: 1 SC injection every 12 hours. Start with an initial dose of 250 Iu/kg
and adjust dosage according to coagulation tests.

Dosage

Preventive treatment
usually: 5000 Iu by SC injection 2 hours before surgery, repeated every 8 to 12 hours.
Dosage depends on patient's weight and risk of thrombo-embolic complications:
150 Iu/kg/day in 2 to 3 divided doses.

About 7 to 10 days or more according to clinical response.


In postoperative period, administer until fully ambulatory.
For long-term therapy, administer heparin simultaneously with oral anticoagulants for 2 to
3 days before stopping heparin.

Duration

188

Do not administer if:


haemorrhage or risk of haemorrhage: haemophilia, active peptic ulcer, acute bacterial
endocarditis, severe hypertension; in postoperative period after neurosurgery or
ophtalmic surgery;
thrombocytopenia or history of heparin-induced thrombocytopenia.
Do not administer by IM route. SC injections must be made deep into abdominal fat,
between umbilicus and iliac crest.
Intramuscular or intra-arterial injections and infiltrations are contra-indicated during heparin
therapy.
May cause:
severe thrombocytopenia, usually after 5 days of heparin, with thrombo-embolic
complications requiring discontinuation of treatment;
localised reactions at the injection site, rarely, necrosis;
allergic reactions, osteoporosis after prolonged use, alopecia;
haemorrhage in case of overdosage, pre-existing lesions, trauma.
use with caution and reduce dosage in elderly patients and in hepatic or renal failure.
Overdosage: neutralise heparin by slow IV injection of protamine. 1 mg protamine neutralises
100 Iu of heparin.
Reduce doses of protamine if more than 15 minutes has elapsed since heparin administration.
Laboratory tests: monitor coagulation parameters in order to adjust dose. Partial thromboplastin time should be maintained at 1.5 to 2 times the control value (Howell's test at 2 to
3 times the control value).
Monitor platelet count prior to initiation of treatment and then 2 times per week.
Avoid combination with aspirin, non-steroidal anti-inflammatory drugs: increased risk of
haemorrhage.
Closely monitor clinical and biological parameters in case of combination with corticosteroids,
dextran, and transition to an oral anticoagulant.
Pregnancy: CONTRA-INDICATED at the end of pregnancy (risk of haemorrhage during delivery)
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Preparations containing calcium salt of heparin are available. Heparin sodium is usually
used by IV route. Both sodium and calcium heparin are used by SC route. There is a little
difference in the action of these 2 medications.
Do not mix with other drugs in the same syringe.
Storage: keep in a cool place (8C to 15C)

Remarks

189

Revised September 2014

HYDRALAZINE

Therapeutic action

Prescription under medical supervision

Antihypertensive vasodilatator

Indications

Hypertension in pregnancy, in case of severe symptoms or when oral treatment is not possible

Presentation and route of administration

Powder for injection, in 20 mg vial, to be dissolved in 1 ml of water for injection, for IV


infusion or slow diluted IV injection

Dosage

Dosage should be adjusted according to blood pressure (BP). The goal is to reduce the blood
pressure to 140/90 mmHg. Diastolic BP must not fall below 90 mmHg.

By IV infusion
Dilute 100 mg (5 vials of reconstituted hydralazine solution) in 500 ml of 0.9% sodium
chloride or Ringer lactate, to obtain a solution containing 200 micrograms/ml.
Initial dose: 200 to 300 micrograms/minute; maintenance dose: 50 to 150 micrograms/minute.
Administer by increasing the rate up to 20 drops/minute (max. 30 drops/min), check BP
every 5 minutes.
As soon as hypertension is controlled, decrease progressively the rate (15 drops/minute,
then 10, then 5) until stopping infusion. An abrupt discontinuation may provoke a
hypertensive crisis.

By slow diluted IV injection


Dilute 20 mg (1 vial of reconstituted hydralazine solution in 1 ml of water for injection)
in 9 ml of 0.9% sodium chloride, to obtain 10 ml of solution containing 2 mg/ml.
Administer 5 mg (2.5 ml of the diluted solution) over 2 to 4 minutes. Check BP for
20 minutes. If BP remains uncontrolled, repeat injection. Continue repeating if necessary,
waiting 20 minutes between each injection (max. 20 mg total dose)

Duration

According to clinical response. Change to oral treatment as soon possible with labetalol or
methyldopa.

Contra-indications, adverse effects, precautions

Administer with caution to patients with heart failure, coronary insufficiency, recent
myocardial infarction, severe tachycardia, history of stroke.
May cause:
hypotension, tachycardia, headache, gastrointestinal disturbances;
abrupt fall in maternal blood pressure with placental hypoperfusion and foetal death
when administered too rapidly by IV injection or in case of overdose.
Reduce doses in patients with renal or hepatic impairment.
Do not exceed recommended dosage and administration rate. During administration,
monitor maternal BP and pulse, as well as foetal heart rate.
In the event of hypotension, administer Ringer lactate to maintain diastolic BP 90 mmHg.
Breast-feeding: no contra-indication

Remarks

For administration, only use sodium chloride 0.9 % or Ringer lactate (incompatibility with
glucose and other solutions).
Do not mix with other drugs in the same syringe or infusion bottle.
Storage: below 25C
Reconstituted solution must be used immediately.

190

HYDROCORTISONE
(Efcortesol, Solu-cortef)

Prescription under medical supervision

Steroidal anti-inflammatory drug (corticosteroid)

Therapeutic action

Symptomatic treatment of severe allergic and inflammatory reactions, e.g.: severe acute
asthma (in addition to inhaled salbutamol), allergic angioedema, anaphylactic shock (as an
adjunct to epinephrine)

Indications

Powder for injection, 100 mg hydrocortisone (hemisuccinate, succinate or phosphate) in


vial, to be dissolved in 2 ml water for injection, for IM or slow IV injection or infusion

Presentation and route of administration

Child under 1 year: 25 mg/injection


Child from 1 to 5 years: 50 mg/injection
Child from 6 to 12 years: 100 mg/injection
Adult: 100 to 500 mg/injection

Dosage and duration

Doses may be repeated 3 or 4 times daily according to the severity of the symptoms and the
patients response.

Avoid prolonged administration in patients with peptic ulcer, diabetes mellitus or cirrhosis.
Administer with caution to patients receiving digitalis glycosides: increases digitalis toxicity
associated with hypokalaemia.
Pregnancy: use only if clearly needed, for a short period
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Hydrocortisone acetate is a suspension insoluble in water, used as a local treatment only:


intra- or peri-articular injection, epidural (sciatic neuralgia).
Storage: below 30C

Remarks

191

HYOSCINE BUTYLBROMIDE = BUTYLSCOPOLAMINE


(Buscopan)

Prescription under medical supervision

Antispasmodic

Therapeutic action

Spasms of the gastrointestinal tract and genitourinary tract

Indications

20 mg in 1 ml ampoule (20 mg/ml) for IM, SC or slow IV injection

Presentation and route of administration

Child under 6 years: 5 mg/injection, to be repeated up to 3 times per day if necessary


Child from 6 years to 12 years: 0.5 mg/kg/injection to be repeated up to 3 to 4 times per
day if necessary
Adult: 20 to 40 mg/injection, to be repeated if necessary; do not exceed 100 mg/day

Dosage

Duration: according to clinical response; no prolonged treatment.

Do not administer to patients with urethro-prostatic disorders, cardiac disorders,


glaucoma.
Do not administer to children with high fever.
May cause: urinary retention, dryness of the mouth, constipation, blurred vision,
tachycardia.
Administer with caution to children under 6 years.
Administer with caution and under close supervision to patients taking other anticholinergic drugs (antidepressants, neuroleptics, H-1 antihistamines, antiparkinsonians,
etc.).
Pregnancy: no contra-indication; NO PROLONGED TREATMENT
Breast-feeding: no contra-indication; NO PROLONGED TREATMENT

Contra-indications, adverse effects, precautions

Antispasmodic drugs are not included in the wHO list of essential medicines.
Storage: below 30C

Remarks

192

INSULIN
Prescription under medical supervision

General information

Pancreatic hormone, antidiabetic

Therapeutic action

There are 3 main types of insulin preparations, differing in onset and duration of action:

Classification

Administration
by SC route

Onset

Time to peak
Duration

Description

Appearance

Short-acting
insulin

Intermediate-acting
insulin

Long-acting
insulin

2 to 5 hours

4 to 12 hours

8 to 20 hours

30 minutes to 1 hour

1 to 2 hours

2 to 4 hours

6 to 8 hours

10 to 24 hours

24 to 36 hours

clear

opalescent

opalescent

solution

suspension

suspension

Duration of action is indicated for each preparation by the manufacturer. For each preparation,
onset and duration vary greatly according to the patient and route of administration.
The type of insulin used depends on the type of diabetes, patient's age and blood glucose
levels.

Insulin-dependent diabetes
Diabetes during pregnancy
Degenerative complications of diabetes : retinopathy, neuropathy...
Non-insulin-dependent diabetics during periods of severe infection, trauma, surgery.

Indications

Dosage must be individualised. Frequency of administration depends on the type of insulin


and the patient's response. There is no standardized protocol.
Never exceed 200 Iu/day, whatever the type of insulin.

Dosage

Insulin-dependent diabetics: life-time treatment


Other cases: according to clinical response and laboratory tests

Duration

193

Do not administer in patients with allergy to insulin (rare).


May cause :
hypoglycaemia due to overdosage or inadequate diet. Treat mild hypoglycaemia with
intake of oral sugar and IV injection of hypertonic glucose solution if severe;
local reactions: pain, erythema at the injection site, lipodystrophy. Rotate injection sites
systematically and use all available sites (upper arm, thighs, abdomen, upper back).
Patient monitoring: blood and urine glucose concentrations, urine ketone tests.
Blood glucose concentrations should be maintained within the range of 4.4 to 8 mmol/litre
under fasting (8 mmol = 1.4 g).
Diabetes is controlled when:
there are no glucose and ketones in urine;
before-meal blood glucose levels are < 1.2 g/litre (< 6.67 mmol/litre);
postprandial blood glucose levels are 1.4 g/litre (< 7.78 mmol/litre).
Treatment of diabetes must be initiated in hospital under close supervision.
Treatment includes: insulin administration, specific diet, education and counselling under
medical supervision (self-monitoring of blood glucose, self-administration of insulin,
knowledge about signs of hypoglycaemia and hyperglycaemia).
Closely monitor combination with:
drugs enhancing hypoglycaemic effect: acetylsalicylic acid, angiotensin-converting
enzyme inhibitors, beta-blockers (which in addition, may mask symptoms of
hypoglycaemia);
drugs increasing blood glucose levels: glucocorticoids, salbutamol, chlorpromazine, oral
contraceptives.
Avoid alcohol: enhances and prolongs hypoglycaemic effect of insulin.
use sterile technique.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Insulin is obtained by extraction from bovine or porcine pancreases. The term monocomponent insulin is used for highly purified insulin.
Insulin of human sequence is prepared either semisynthetically by modification of porcine
material or biosynthetically.
Preparations of human or animal origin have the same hypoglycemic effect. There is
generally no significant difference.
Insulin cannot be administered by mouth since it is inactivated in the gastro-intestinal tract.

Remarks

194

INTERMEDIATE-ACTING INSULIN

(Insulatard, Semitard)
LONG-ACTING INSULIN

(Ultralente, Ultratard)

Prescription under medical supervision

Insulin suspension modified by addition of protamine and/or zinc, in order to prolong the
duration of action

Therapeutic action

As for insulin in general, except in the emergency treatment of diabetic ketoacidosis and
coma

Indications

400 Iu of insulin suspension in 10 ml vial (40 Iu/ml) for deep SC injection, administered
with a calibrated syringe for Iu-40 insulin.
Also comes in solution containing 100 Iu/ml, administered only with calibrated syringe for
Iu-100 insulin.
IM route may be used but SC route is less painfull and drug action is longer and more regular.

Presentation and route of administration

20 to 40 Iu/day divided in 2 injections for intermediate-acting insulin, in 1 or 2 injections


for long-acting insulin.
Administer 15 to 30 minutes before meals. Increase by 2 Iu/day until reaching the blood
glucose level required. Adjust dosage and frequency of injections according to patient's
needs.
Short-acting insulin is often administered in combination with an intermediate-acting or
long-acting insulin.
Examples of regimens:

Dosage

Insulin

Short-acting insulin
Intermediate-acting insulin
Short-acting insulin
Long-acting insulin

Intermediate-acting with or without


short-acting insulin

Administration

2 times/day before breakfast and lunch


at bedtime

3 times/day before breakfast, lunch and


dinner
at bedtime or before breakfast

2 times/day before breakfast and dinner

See "insulin: general information".


Never administer by IV injection.
Do not administer if known allergy to protamine.
Shake suspension gently before use. Remove from the refrigerator 1 hour before administration
or roll the vial between hands.

Contra-indications, adverse effects, precautions

Storage: to be kept refrigerated (2C to 8C)


Do not freeze; discard if freezing occurs.
Most manufacturers consider that a solution stored by the patient at a temperature up to 25C
and protected from light is stable for 1 month.

Remarks

195

SHORT-ACTING INSULIN

(Actrapid, Velosulin)

Prescription under medical supervision

Soluble insulin, sometimes called neutral insulin, regular insulin or unmodified insulin.

Therapeutic action

As for insulin in general, particularly in cases of diabetic ketoacidosis and diabetic coma.

Indications

400 IU of insulin in 10 ml vial (40 IU/ml) for deep SC injection, IM or IV injection,


administered with a calibrated syringe for IU-40 insulin.
Also comes in solution containing 100 IU/ml, administered only with calibrated syringe for
IU-100 insulin.

Presentation and route of administration

Emergency treatment of ketoacidosis and diabetic coma


Child: initial dose 0.1 IU/kg by direct IV injection followed by 0.3 IU/kg every 4 hours.
Adult: initial dose of 5 to 20 IU by direct IV injection followed by 10 to 20 IU every hour
via the drip tubing. When ketone bodies are cleared and blood glucose level has fallen
to less than 20 mmol/litre, give 20 IU by SC injection every 4 to 6 hours according to
blood glucose level.
Treat dehydration with a sodium chloride solution, then glucose-saline solution.
Correct cautiously acidosis with isotonic solution of bicarbonate and, if necessary, postinsulinic hypokalaemia.

Dosage

Treatment of diabetes mellitus


Start with 5 IU, 15 minutes before meals, 3 to 4 times/day by SC injection. Adjust dosage
according to blood glucose levels before and after meal. Adjustments should not exceed
10 IU/day.
When hyperglycemia is controlled, an intermediate-acting insulin may be substituted in
order to limit injections.
Short-acting insulin may be mixed with intermediate-acting insulin in the proportion of
10 to 50%.
See "Insulin: general information".

Contra-indications, adverse effects, precautions


The terms "cristalline insulin" and "neutral insulin" are used either for soluble insulin or
intermediate and long-acting insulin.
Storage: to be kept refrigerated (2C to 8C)
Do not freeze.
Most manufacturers consider that a solution stored by the patient at a temperature up to 25C
and protected from light, is stable for 1 month.

Remarks

196

KETAMINE
Prescription under medical supervision
Therapeutic action

General anaesthetic

Indications

Induction and maintenance of general anaesthesia

Presentation and route of administration

250 mg in 5 ml ampoule (50 mg/ml) for IM, IV injection or infusion

Dosage

Child and adult:


Induction
IV: 2 mg/kg to be injected slowly. Anaesthesia is produced within one minute and lasts
for 10 to 15 minutes.
IM: 10 mg/kg. Anaesthesia is produced within 5 minutes and lasts for 15 to 30 minutes.
Maintenance
IV: 0.5 to 1 mg/kg depending on recovery signs (approximately every 15 minutes)
IM: 5 mg/kg approximately every 20 to 30 minutes

Duration

Depending on duration of the operation

Contra-indications, adverse effects, precautions

Do not administer to patients with intraocular hypertension, pre-eclampsia.


Administer with caution to patients with arterial or intracranial hypertension, coronary
insufficiency, psychiatric disorders.
May cause: hypertension, hypersalivation, hallucinations during recovery (less frequent in
children or when injected IM), apnoea following rapid IV injection.
Premedication to prevent hypersalivation and hallucinations:
atropine IV: 0.01 to 0.015 mg/kg + diazepam slow IV: 0.1 mg/kg, during induction
or
atropine IM : 0.01 to 0.015 mg/kg + diazepam IM : 0.1 mg/kg, 30 minutes before induction
Technical equipment for intubation and ventilation must be available and ready for use.
Pregnancy: no contra-indication, except in pre-eclampsia. For ceaserean sections, do not exceed
1 mg/kg by IV injection (risk of neonatal respiratory depression at higher doses).
Breast-feeding: no contra-indication

Remarks

Ketamine has no muscle relaxant properties.


In some countries, ketamine is on the list of narcotics: follow national regulations.
Also comes in 10 ml ampoule containing 500 mg (50 mg/ml).
Storage: below 25C

197

LABETALOL
Prescription under medical supervision
Therapeutic action

Non cardioselective beta-blocker

Indications

Hypertension in pregnancy, in case of severe symptoms or when oral treatment is not possible

Presentation and route of administration

100 mg ampoule (5 mg/ml, 20 ml) for IV injection

Dosage

Dosage should be adjusted according to blood pressure (BP). The goal is to reduce the blood
pressure to 140/90 mmHg. Diastolic BP must not fall below 90 mmHg.

One dose of 20 mg (4 ml) over at least one minute. If hypertension remains uncontrolled
5 and 10 minutes after injection, administer another dose of 20 mg (4 ml). Administer
additional doses of 40 mg (8 ml) then 80 mg (16 ml) at 10 minute intervals as long as
hypertension is not controlled (max. 300 mg total dose).

Duration

According to clinical response. Change to oral treatment as soon as possible.

Contra-indications, adverse effects, precautions

Do not administer to patients with asthma, chronic obstructive bronchopneumonia, heart


failure, severe hypotension, bradycardia < 50/minute, atrio-ventricular heart blocks,
Raynaud's syndrome, hepatic impairment.
May cause:
bradycardia, orthostatic hypotension, heart failure, bronchospasm, hypoglycaemia,
gastrointestinal disturbances, dizziness, headache, weakness, urinary retention;
abrupt fall in maternal blood pressure with placental hypoperfusion and foetal death
when administered too rapidly by IV injection or in case of overdose.
Administer with caution to patients with diabetes (risk of hypoglycaemia).
Reduce dosage in patients with renal impairment.
In the event of anaphylactic shock, risk of resistance to epinephrine.
Avoid or monitor combination with: mefloquine, digoxin, amiodarone, diltiazem, verapamil
(risk of bradycardia); tricyclic antidepressants, neuroleptics, other anti- hypertensive drugs
(risk of hypotension).
Monitor the newborn: risk of hypoglycaemia, bradycardia, respiratory distress occurring
most often during the first 24 hours and until 72 hours after the birth.
In the event of hypotension, administer Ringer lactate to maintain diastolic BP 90 mmHg.
Breast-feeding: no contra-indication

Remarks

Storage: below 25C

Revised February 2015

LEVONORGESTREL subdermal implant

Therapeutic action

Prescription under medical supervision

Hormonal contraceptive, progestogen

Indications

Long-term hormonal contraception

Presentation and route of administration

Set of two flexible rods containing 75 mg of levonorgestrel, with a sterile applicator


(reusable after sterilization or for single use only, depending on the presentation), to be
inserted subdermally into the inner side of the non-dominant arm, 6 to 8 cm above the
elbow crease, under local anaesthesia and aseptic conditions

Dosage

If no current contraception, the implant is inserted:


during the first 7 days of menstruation or immediately after abortion
after childbirth: as of the 4th week postpartum if the woman breastfeeds or as of the
21st day postpartum if the woman does not breastfeed
When switching from another contraceptive method, the implant is inserted:
for an oral estroprogestogen: the day after taking the last active tablet in the pack
for an oral progestogen: at any stage of the cycle
for an injectable progestogen: the day the next injection is due
for an intrauterine device or another implant: the day of its removal
However, if there is a risk that the woman may be lost to follow-up, the implant may be
inserted as soon as the opportunity occurs, including before the timing proposed. If the
implant is inserted later (in the absence of pregnancy), it is recommended to use condoms
during the first 7 days after the insertion.

Duration

As long as contraception is desired and it is well tolerated, for max. 5 years (4 years in obese
women) after which it no longer provides contraception and must be changed.

Contra-indications, adverse effects, precautions

Do not administer to patients with breast cancer, severe or recent liver disease, unexplained
vaginal bleeding, current thromboembolic disorders.
May cause: menstrual irregularities, amenorrhoea, menometrorrhagia, breast tenderness,
headache, weight gain, itching, acne, mood changes, abdominal pain, gastrointestinal
disturbances, allergic reactions.
Hepatic enzyme inducers (rifampicin, rifabutin, nevirapine, nelfinavir, ritonavir,
phenobarbital, phenytoin, carbamazepine, griseofulvin, etc.) may reduce the contraceptive
efficacy. Use a copper intrauterine device or condoms or injectable medroxyprogesterone
or an oral contraceptive containing 50 micrograms ethinylestradiol (however there is still a
risk of oral contraceptive failure and the risk of adverse effects is increased).
Pregnancy: CONTRA-INDICATED
Breast-feeding: it is recommended to wait 4 weeks after childbirth before inserting the implant.

Remarks

Implants provide long term contraception, their efficacy is not conditioned by observance.
Fertility returns rapidly after removal of the implant.
The duration of action of the levonorgestrel implant (5 years) is longer than that of the
etonogestrel implant (3 years). However, the etonogestrel implant (one rod) is easier to
insert and remove than the levonorgestrel implant (2 rods).
For the conditions for insertion or removal the implant, follow manufacturers instructions.
Storage: below 25C
199

LIDOCAINE = LIGNOCAINE
(Xylocaine)

Prescription under medical supervision

Local anaesthetic

Therapeutic action

Local anaesthesia: minor operations : 1% lidocaine plain


dental surgery : 2% lidocaine (plain or with epinephrine)

Indications

1% solution in 20 and 50 ml vials (10 mg/ml), for SC infiltration


2% solution in 20 and 50 ml vials (20 mg/ml), for SC infiltration

Presentation and route of administration

The volume to be injected depends on the surface area to be anesthetised.


Do not exceed: Child: 5 mg/kg/injection
Adult: 200 mg = 20 ml of lidocaine 1% or 10 ml of lidocaine 2%

Dosage

AGE

WEIGHT

1 % solution, 10 mg/ml
2 % solution, 20 mg/ml

2
months
4
kg

2 to 3 ml

1
year
8
kg

1 to 1 1/2 ml

5
years

4 to 8 ml

2 to 4 ml

15
kg

15
years

9 to 15 ml
4 to 7 ml

35
kg

ADULT

15 to 20 ml
7 to 10 ml

Duration: one injection, repeated if necessary


Do not administer if known allergy to lidocaine, impaired cardiac conduction.
When anaesthetising the extremities, inject distally (at the base), in circle, without tourniquet
and without epinephrine (adrenaline).
Do not use lidocaine for the incision of abscesses: risk of spreading the infection.
Lidocaine with epinephrine (adrenaline):
in dental surgery, epinephrine added to lidocaine prolongs anaesthesia;
never use solutions with epinephrine for the anaesthesia of extremities (fingers, penile
nerve block): risk of ischemia and necrosis.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Anaesthesia is produced within 2 to 5 minutes and lasts 1 to 1.5 hours.


Do not confuse with lidocaine 5% hyperbaric which is reserved for spinal anaesthesia.
The more concentrated the lidocaine, the more localised the anaesthetic effect.
To simplify protocols, use lidocaine 2% with epinephrine for dental anaesthesia and
lidocaine 1% without epinephrine for cutaneous anaesthesia.
Storage: below 30C

Remarks

199

Revised December 2014

MAGNESIUM SULFATE = MgSO4

Therapeutic action

Prescription under medical supervision

Anticonvulsant

Indications

Severe pre-eclampsia: prevention of eclamptic seizures


Eclampsia: treatment of eclamptic seizures and prevention of recurrence

Presentation and route of administration

5 g ampoule (0,5 g/ml, 10 ml) for IM injection or IV infusion

Dosage and duration

IV/IM protocol
4 g by IV infusion in 100 ml of 0.9% sodium chloride over 15 to 20 minutes then, 10 g by IM
route (5 g in each buttock) then, 5 g by IM route every 4 hours (changing buttock for each
injection)
IV protocol
4 g by IV infusion in 100 ml of 0.9% sodium chloride over 15 to 20 minutes then 1 g per
hour by continuous IV infusion
Regardless of the protocol chosen:
Continue the treatment for 24 hours after the delivery or the last seizure.
If seizures persist or recur, administer a further 2 g (patients less than 70 kg) to 4 g by IV
infusion, without exceeding 8 g total dose during the first hour.

Contra-indications, adverse effects, precautions

Reduce the dose in patients with renal impairment; do not administer to patients with severe
renal impairment.
May cause:
pain at the injection site, warm flushes; decreased fetal heart rate.
in case of overdosage (hypermagnesaemia):
- For the mother: diminished then absent patellar reflex (early sign), hypotension,
drowsiness, confusion, difficulty in speaking, bradycardia, respiratory depression
(respiratory rate < 12/minute).
- For the neonate: hypotonia, neurobehavioural impairment, apnoea, respiratory
depression.
Do not combine with nifedipine.
Check urine output every hour. In the event of decreased urine output (< 30 ml/hour or
100 ml/4 hour), stop magnesium sulfate and perform delivery as soon as possible. If
delivery cannot be performed immediately in a woman with eclampsia, stop magnesium
sulfate for one hour then resume magnesium sulfate perfusion until delivery.
Check patellar reflex, blood pressure, heart and respiratory rate every 15 minutes during
the first hour of treatment. If no signs of overdosage are observed, continue this
surveillance every hour. If signs of overdosage are observed: stop magnesium sulfate and
give 1 g calcium gluconate by slow IV route as an antidote (in this event, seizures may recur).
Breast-feeding: no contra-indication

Remarks

Also comes in ampoules containing 1 g (0.5 mg/ml, 2 ml) and many other dosages. Check
the strength of the ampoule carefully before use.
1 g magnesium sulfate contains approximately 4 mmol (8 mEq) of magnesium.
Do not mix with other drugs in the same syringe or infusion fluid.
Storage: below 25C

201

Revised May 2015

MEDROXYPROGESTERONE

Therapeutic action

Prescription under medical supervision

Hormonal contraceptive, progestogen

Indications

Long term hormonal contraception

Presentation and route of administration

150 mg in 1 ml vial (150 mg/ml) for IM injection


Medroxyprogesterone is a suspension: shake vial well before use.

Dosage

150 mg per IM injection, one injection every 12 weeks. The following injections may be
administered within the 2 weeks before the scheduled date and up to 2 weeks after, without
the need for additional contraception.
If no current contraception, the first injection is given:
during the first 5 days of menstruation or immediately after abortion
after childbirth: as of the 6th week if the woman breastfeeds or between the 1st and the
21st day postpartum if the woman does not breastfeed. In post-partum period, it is better
to wait until the 5th day if possible, as the risk of bleeding is increased if the injection is
administered between D0 and D4.

When switching from another contraceptive method, the first injection is given:
for an oral oestroprogestogen or progestogen: the day after taking the last active tablet
in the pack
for an intrauterine device or an implant: the day of its removal

However, if there is a risk that the woman may be lost to follow-up or if this is the only
available or acceptable contraceptive, the injection may be given as soon as the opportunity
occurs, including before the timing proposed. If the injection is given later (in the absence of
pregnancy), it is recommended to use condoms during the first 7 days after injection.

Duration

As long as contraception is desired.

Contra-indications, adverse effects, precautions

Do not administer to patients with breast cancer, uncontrolled hypertension, current


thromboembolic disorders, non-equilibrated or complicated diabetes, severe or recent liver
disease, unexplained vaginal bleeding.
May cause: menstrual irregularities, amenorrhoea, menometrorrhagia, breast tenderness,
headache, weight gain, itching, acne, mood change, abdominal pain, gastrointestinal
disturbances, allergic reactions.
The contraceptive efficacy of medroxyprogesterone does not seem to be reduced in women
taking hepatic enzyme inducers.
Pregnancy: CONTRA-INDICATED
Breast-feeding: it is recommended to wait 6 weeks after childbirth before starting injections.

Remarks

It may take as long as a year for fertility to return to normal after stopping injections.
Storage: below 25C

202

MELARSOPROL
(Arsobal)

Prescription under medical supervision

Trypanocide (arsenical derivative)

Therapeutic action

Meningoencephalitic stage of African trypanosomiasis due to T. b. gambiense and T. b. rhodesiense

Indications

180 mg in 5 ml ampoule (36 mg/ml), 3.6 % solution in propylene glycol, for slow IV injection.
nEVER by IM OR SC InjECTIOn.

Presentation and route of administration

Patients must be treated in hospital under close medical supervision.

Dosage and duration

Gambiense trypanosomiasis
Child and adult: 2.2 mg/kg (max. 5 ml) once daily for 10 consecutive days

Rhodesiense trypanosomiasis
Child and adult: 3.6 mg/kg/injection (i.e. 1 ml/10 kg, without exceeding 5 ml/injection).
The treatment consists of 9 to 12 injections in total, administered as 3 to 4 courses of 3 to
4 injections (one per day), with an interval of 7 to 10 days between each course.
It is recommended to start with an initial low dose (1.2 to 1.8 mg/kg) then, to increase
gradually to the maximum dose of 3.6 mg/kg.
May cause:
reactive encephalopathy (5-10 % of cases): repeated or prolonged seizures, coma, psychical
disorders, usually between the 5th and the 8th day of the ten-day treatment (but sometimes
later, even after the patient has been discharged) or just before/during the 2nd course of
the intermittent treatment;
arsenical reactions: headache, fever, tachycardia, hypertension, jaw pain, neurological
disorders (hyperreflexia);
gastrointestinal disturbances, skin reactions (exfoliative dermatitis, urticaria), peripheral
neuropathy, haematological disorders (haemolytic anaemia in patients with G6PD
deficiency, agranulocytosis), hepatic or renal impairment, myocardial damage;
swelling, pain, phlebitis, venous sclerosis, necrosis at injection site in the event of
extravasation during IV administration.
Use a completely dry syringe: the solution precipitates in presence of water. As propylene
glycol can dissolve plastic, the drug should preferably be administered using a glass syringe
(only if sterilisation is reliable), otherwise inject immediately (but slowly) using a plastic
syringe.
Pregnancy: CONTRA-INDICATED

Contra-indications, adverse effects, precautions

Oral prednisolone is frequently associated during the course of treatment.


For the treatment of meningoencephalitic stage of gambiense trypanosomiasis, the drug of
choice is eflornithine.
Storage: below 25C

Remarks

204

METAMIZOLE = DIPYRONE = NORAMIDOPYRINE


(Nolotil, Novalgin)

USE

Prescription under medical supervision

THIS DRUG ONLY IN SERIOUS SITUATIONS WHERE NO ALTERNATIVE

IS AVAILABLE.

it is potentially harmful;
it is forbidden to market this drug in many countries;
it must never be prescribed as a first choice treatment.

Analgesic
Antipyretic

Therapeutic action

Severe pain
High fever

Indications

1 g in 2 ml ampoule (500 mg/ml) for IM, SC or slow IV injection or infusion

Presentation and route of administration


Child: 10 mg/kg/injection
Adult: 500 mg/injection

Dosage
AGE

WEIGHT

2
months
4
kg

500 mg/ml ampoule

1
year
8
kg

5
years
0.2 ml

15
kg

15
years
0.5 ml

Repeat every 8 hours if necessary

35
kg

ADULT

1 to 2 ml

Duration: according to clinical response


Do not administer in gastric ulcer.
May cause: severe and fatal cases of agranulocytosis. The risk is unpredictable and
independent of the administered dose.
Pregnancy: avoid
Breast-feeding: avoid

Contra-indications, adverse effects, precautions

Metamizole is not included in the WHO list of essential medicines.


Storage: no special temperature requirements

Remarks

205

Revised April 2015

METHYLERGOMETRINE

Therapeutic action

Prescription under medical supervision

Uterotonic, oxytocic

Indications

Treatment of postpartum haemorrhage due to uterine atony (preferably use oxytocin for
this indication)

Presentation and route of administration

200 micrograms in 1 ml ampoule (200 micrograms/ml), for IM injection

Dosage

Adult: 200 micrograms/injection, to be repeated every 2 to 4 hours if necessary, without


exceeding a total of 5 injections

Contra-indications, adverse effects, precautions

Do not administer during delivery or labour.


Do not administer in case of allergy to ergot alkaloids (cabergoline, bromocriptine, ergotamine,
etc.), severe hypertension, pre-eclampsia, eclampsia, and septicaemia.
Do not combine with another ergot alkaloid.
Administer with caution to patients with hepatic or renal impairment, ischemic disorders.
Do not administer simultaneously with prostaglandins or oxytocin (addition of uterotonic
activity).
May cause: gastrointestinal disturbances, headache, paraesthesia, confusion, dizziness,
tinnitus, hypertension, peripheral vasoconstriction, chest pain.
Monitor combination with: metronidazole, azole antifungals, macrolides, protease inhibitors,
efavirenz, fluoxetine (risk of ergotism).
Pregnancy: CONTRA-INDICATED
Breast-feeding: avoid

Remarks

Do not confuse with dihydroergotamine, another ergot alkaloid used for totally different
indications.
Methylergometrine is also called methylergonovine or methylergobasine.
Ergometrine is another uterotonic used for the same indications.
Storage: to be kept refrigerated (2C to 8C). Do not freeze
Expiry date indicated on the label is only valid if stored under refrigeration and protected from
light. Exposure to heat and especially light causes the deterioration of the active ingredient and
thus loss of efficacy.
The solution must be colourless. Discolouration indicated a deterioration of the active ingredient.
Never use a coloured solution.
If refrigeration is not available, vials can be kept for one month on condition that they are
protected from light and the temperature remains under 25C.

205

METOCLOPRAMIDE
(Primperan)

Prescription under medical supervision

Antiemetic (dopamine antagonist)

Therapeutic action

Prevention or symptomatic treatment of nausea and vomiting in adults

Indications

10 mg in 2 ml ampoule (5 mg/ml) for IM or slow IV injection (3 minutes minimum)

Presentation and route of administration

Adult: 10 mg every 8 hours if necessary

Dosage

Duration: according to clinical evolution, as short as possible


Do not administer to children < 18 years and to patients with gastrointestinal haemorrhage,
obstruction or perforation.
Reduce the dose by half in patients with severe renal impairment.
Administer with caution and monitor use in patients > 60 years and patients with epilepsy
or Parkinson's disease.
May cause: drowsiness, dizziness, confusion, extrapyramidal symptoms, seizures (especially
in epileptics), allergic reactions, cardiac disorders (hypotension, bradycardia, cardiac
arrest); neuroleptic malignant syndrome (unexplained hyperthermia with neuromuscular
disorders), rare but requiring immediate treatment discontinuation.
Do not combine with levodopa (antagonism).
Avoid combination with CnS depressants (opioid analgesics, antipsychotics, sedatives, antidepressants, antihistamines, etc.) and antihypertensive drugs (increased risk of hypotension).
Pregnancy: no contraindication
Breast-feeding: no contraindication

Contra-indications, adverse effects, precautions

For postoperative nausea and vomiting in adults, efficacy of metoclopramide is limited.


Higher doses are used for prevention and treatment of chemotherapy-induced nausea and
vomiting: 2 to 10 mg/kg/day by IV infusion.
Metoclopramide is also used as a gastrointestinal prokinetic agent in patients receiving
enteral feeding by a nasogastric tube in intensive care units.
Storage: below 30C

Remarks

207

METRONIDAZOLE
(Flagyl)

Prescription under medical supervision

Antiprotozoal, antibacterial

Therapeutic action

Severe infections due to anaerobic bacteria (Bacteroides sp, Clostridium sp, etc.), usually in
combination with other antibacterials, only when oral administration is not possible

Indications

500 mg in 100 ml vial or bag (5 mg/ml), for infusion

Presentation and route of administration

Child: 20 to 30 mg/kg/day in 2 to 3 divided doses administered over 20 to 30 minutes


Adult: 1 to 1.5 g/day in 2 to 3 divided doses administered over 20 to 30 minutes (one
500 mg-vial 2 to 3 times per day)

Dosage

According to indication. Change to oral treatment as soon as possible.

Duration

Do not administer to patients with allergy to metronidazole or another nitroimidazole


(tinidazole, secnidazole, etc.).
Do not drink alcohol during treatment.
May cause: gastrointestinal disturbances, brownish urine, allergic reactions, headache,
dizziness.
Monitor combination with anticoagulants (increased risk of haemorrhage), lithium, phenytoin
and ergometrine (increased plasma concentrations of these drugs).
Administer with caution, reduce total daily dose to 1/3 and give once daily to patients with
severe hepatic impairment.
Pregnancy: no contra-indication, avoid prolonged use
Breast-feeding: avoid (significantly excreted in milk)

Contra-indications, adverse effects, precautions

Metronidazole is as effective by oral route than by parenteral route.


Do not add any drugs in the infusion vial.
Storage: below 30C

Remarks

208

MORPHINE
Prescription under medical supervision
Centrally acting opioid analgesic

Therapeutic action

Severe pain, especially in surgery, trauma and neoplastic disease

Indications

10 mg ampoule (10 mg/ml, 1 ml) for SC, IM or IV injection

Presentation and route of administration

SC and IM route
Child over 6 months and adult: 0.1 to 0.2 mg/kg/injection, to be repeated every 4 hours if
necessary

Dosage

IV route
Child over 6 months and adult: 0.1 mg/kg administered in fractionated doses (0.05 mg/kg
every 10 minutes), to be repeated every 4 hours if necessary

Duration: change to oral treatment as soon as possible.

Do not administer to patients with severe respiratory impairment or decompensated hepatic


impairment.
May cause:
dose-related sedation and respiratory depression, nausea, vomiting, constipation, urinary
retention, confusion, raised intracranial pressure, pruritus;
in the event of overdose: excessive sedation, respiratory depression, coma.
Management of respiratory depression includes assisted ventilation and/or administration
of naloxone. Monitor patient closely for several hours.
Administer with caution to patients with respiratory impairment, head injury, raised intracranial pressure, uncontrolled epilepsy or urethroprostatic disorders.
In elderly patients and in patients with severe renal or hepatic impairment: reduce doses
by half and administer less frequently, according to clinical response (risk of accumulation)
Do not combine with opioid analgesics with mixed agonist-antagonist activity such as
buprenorphine, nalbuphine, pentazocine (competitive action).
Increased risk of sedation and respiratory depression, when combined with alcohol and
drugs acting on the central nervous system: benzodiazepines (diazepam, etc.), neuroleptics
(chlorpromazine, haloperidol, etc.), antihistamines (chlorphenamine, promethazine),
phenobarbital, etc.
Pregnancy and breast-feeding: no contra-indication. The child may develop withdrawal symptoms,
respiratory depression and drowsiness when the mother receives morphine at the end of the 3rd trimester
and during breast-feeding. In these situations, administer with caution, for a short period, at the
lowest effective dose, and monitor the child.

Contra-indications, adverse effects, precautions

Administer an appropriate laxative (e.g. lactulose) if analgesic treatment continues more


than 48 hours.
Morphine is on the list of narcotics: follow national regulations.
Storage:

Remarks

209

NALOXONE
(Nalone, Narcan, Zynox)

Prescription under medical supervision

Specific opioid antagonist

Therapeutic action

Respiratory depression induced by opioids (analgesia, anaesthesia, intoxication)


Respiratory depression in newborns resulting from the administration of opioids to the
mother

Indications

0.4 mg in 1 ml ampoule (0.4 mg/ml) for IV, IM injection or infusion in sodium chloride 0.9%
or glucose 5%
Also comes in 10 ml ampoule containing 4 mg (0.4 mg/ml) and 2 ml ampoule containing
40 g (20 g/ml) for paediatric use.

Presentation and route of administration

newborn: initial dose of 10 g/kg by IV injection, followed by 10 g/kg by IM injection


every 90 minutes

Dosage

Child:

Adult:

5 to 10 g/kg by IV injection, repeated if necessary after 2 to 3 minutes, until


adequate spontaneous ventilation is restored, followed by a continuous infusion
of 1 to 5 g/kg/hour, or by 5 to 10 g/kg by IM injection every 90 minutes
1 to 3 g/kg by IV injection, repeated if necessary after 2 to 3 minutes, until
adequate spontaneous ventilation is restored, followed by a continuous infusion
of 1 to 5 g/kg/hour, or by 5 to 10 g/kg by IM injection every 90 minutes.

The duration of action of naloxone (20 to 30 minutes by IV route) is shorter than that of
opioids: administration must be maintained several hours even if breathing improves.

Duration

May cause:
tachycardia, fibrillation, hypertension, pulmonary oedema when given postoperatively,
due to a sudden reversal of analgesia;
nausea, vomiting;
acute withdrawal syndrome in opioid-dependent patients.
Administer with caution and reduce dosage in case of heart failure or coronary artery
disease.
naloxone is used in addition to assisted ventilation and must be administered under close
medical supervision.
Pregnancy: risks linked to respiratory depression appear greater than risks linked to naloxone
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

naloxone is a specific opioid antidote. It cannot be used to antagonise the effects of other
drugs producing CnS or respiratory depression.
Efficacy in antagonising opioid effects depends not only on the dose of naloxone but also
on the dose and potency of the specific opioid involved.
IV route is preferred, use IM route if IV route is not feasible.
Storage:

Remarks

210

OMEPRAZOLE
(Mopral)

Prescription under medical supervision

Antiulcer drug (proton pump inhibitor)

Therapeutic action

Peptic ulcer perforation

Indications

Powder for injectable solution, 40 mg vial, to be dissolved in 100 ml of 0.9% sodium


chloride or 5% glucose, for IV infusion

Presentation and route of administration

Adult: 40 mg once daily to be administered over 20 to 30 minutes

Dosage

Duration: change to oral treatment as soon as the patient can eat.

May cause: headache, diarrhoea, skin rash, nausea, abdominal pain, dizziness.
Avoid combination with itraconazole and ketoconazole (decreases efficacy of these drugs).
Monitor combination with warfarin, digoxin, phenytoin.
Do not exceed 20 mg/day in patients with severe hepatic impairment.
Pregnancy: no contra-indication
Breast-feeding: avoid, administer only if clearly need

Contra-indications, adverse effects, precautions

Only use 0.9% sodium chloride or 5% glucose for dilution.


Injectable omeprazole is not included in the WHO list of essential medicines.
Storage: below 30C

Remarks

213

Revised September 2014

OXYTOCIN
(Syntocinon)

Therapeutic action

Prescription under medical supervision

Synthetic oxytocic

Indications

Induction and augmentation of labour in the event of dynamic dystocia


Treatment of postpartum haemorrhage due to uterine atony
Prevention of postpartum haemorrhage, after vaginal delivery or caesarean section

Presentation and route of administration

10 IU in 1 ml ampoule (10 IU/ml) for IM or slow IV injection or infusion

Dosage

Induction and augmentation of labour


Start an infusion of 5 IU in 500 ml or 10 IU in 1 litre of Ringer lactate or 0.9% sodium chloride.
Initially 5 to 8 drops/minute, then increase by 5 to 8 drops/minute every 30 minutes (max.
60 drops/minute) until efficient contractions are obtained (3 contractions lasting 40 seconds
over 10 minutes).

Treatment of postpartum haemorrhage due to uterine atony


20 IU in 1 litre of Ringer lactate or 0.9% sodium chloride, administered over 2 hours
(160 drops/minute). Simultaneously, 5 to 10 IU by slow IV injection, to be repeated if
necessary until the uterus is retracted (max. total dose 60 IU).
Prevention of postpartum haemorrhage (vaginal delivery)
5 to 10 IU by slow IV or IM injection before or after the delivery of placenta

Prevention of postpartum haemorrhage (caesarean section)


10 IU by slow IV injection after cord clamping, then 20 UI in 1 litre of Ringer lactate or 0.9%
sodium chloride, administered over 2 hours (160 drops/minute).

Duration

According to clinical response

Contra-indications, adverse effects, precautions

Do not administer by rapid IV injection (risk of hypotension with flushing and reflex
tachycardia, uterine hypertonia and/or rupture, foetal distress).
During labour:
Do not administer to patients with history of two caesarean sections or more.
Administer with caution and do not exceed 30 drops/minute in patients with history of
single caesarean section and in grand multipara (risk of uterine rupture).
Respect the dosage and rate of administration, monitor uterine contractility and foetal
heart rate.
May cause: nausea, vomiting, heart rhythm disorders.
Do not administer simultaneously with prostaglandins. Only administer oxytocin 6 hours
after the last administration of prostaglandins.

Remarks

Storage: to be kept refrigerated (2C to 8C). Do not freeze.


Expiry date indicated on the label is only valid if stored under refrigeration and protected from
light. Exposure to light and heat causes the deterioration of the active ingredient and thus loss of
efficacy.
If refrigeration is not available, ampoules kept below 25C and protected from light may be stored
for a maximum of one month.

215

PARACETAMOL = ACETAMINOPHEN
(Perfalgan, Perfusalgan)

Prescription under medical supervision

Analgesic, antipyretic

Therapeutic action

Very high fever, only when oral administration is not possible


Mild pain, only when oral administration is not possible

Indications

500 mg vial (10 mg/ml, 50 ml), for infusion

Presentation and route of administration

neonate and child < 10 kg: 7.5 mg/kg (0.75 ml/kg) every 6 hours, to be administered over
15 minutes. Do not exceed 30 mg/kg/day.
Patient 10 to 50 kg: 15 mg/kg (1.5 ml/kg) every 6 hours, to be administered over 15 minutes.
Do not exceed 60 mg/kg/day.
Patient over 50 kg: 1 g (100 ml) every 6 hours, to be administered over 15 minutes. Do not
exceed 4 g/day.

Dosage

According to clinical response. Change to oral route as soon as possible.

Duration

Do not administer to patients with severe hepatic impairment.


Administer with caution to patients with moderate hepatic impairment, severe renal
impairment, chronic alcoholism, malnutrition, dehydration.
May cause (very rarely): malaise, hypotension and rash.
Do not exceed indicated doses, especially in children and elderly patients. Paracetamol
intoxications are severe (hepatic cytolysis).
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

As the efficacy of IV paracetamol is not superior to the efficacy of oral paracetamol, the
IV route is restricted to situations where oral administration is not possible.
For mild pain, IV paracetamol is used alone or in combination with an nSAID administered
parenterally.
For moderate pain, IV paracetamol is used in combination with an nSAID and tramadol
administered parenterally.
For severe pain, IV paracetamol is used in combination with an nSAID and morphine
administered parenterally.
Paracetamol has no anti-inflammatory properties.
Do not mix with other drugs in the same infusion bottle.
Storage: below 30C

Remarks

215

PENTAMIDINE
(Pentacarinat, Pentam)

Prescription under medical supervision

Antiprotozoal active against Pneumocystis jiroveci (carinii)

Therapeutic action

Second-line treatment of pneumocystosis, in the event of contra-indication, intolerance or


unresponsiveness to cotrimoxazole

Indications

Powder for injection, 200 mg and 300 mg vials, to be dissolved in 10 ml water for injection,
for IM injection or infusion in 250 ml of 5% glucose

Presentation and route of administration

Child and adult: 4 mg/kg once daily by IM injection or slow infusion (over 60 minutes
minimum) for 14 to 21 days

Dosage and duration

Do not administer to patients with severe renal impairment.


Reduce dosage in patients with renal impairment.
May cause:
aseptic abscess by IM route; venous thrombosis by IV route,
malaise, hypotension, particularly if administered too rapidly by IV route,
gastrointestinal disturbances; renal, hepatic and haematologic disorders; pancreatitis,
arrhythmia, torsades de pointes, hypoglycaemia followed by hyperglycaemia.
Do not combine with drugs inducing torsades de pointes: anti-arrhythmics, neuroleptics,
tricyclic antidepressants, IV erythromycin, halofantrine, etc.
Avoid combination with: mefloquine, cardiac glycosides, azole antifungals, drugs inducing
hypokalaemia (diuretics, glucocorticoids, injectable amphotericin b, etc.).
Administer on a empty stomach, keep the patient supine during injection and 30 min after.
Monitor blood pressure, blood glucose level, serum creatinine level, blood counts.
Pregnancy and breast-feeding: CONTRA-INDICATED, except if vital and there is no therapeutic
alternative

Contra-indications, adverse effects, precautions

For the prophylaxis of pneumocystosis, pentamidine may be used by inhalation of nebulised


solution using suitable equipment.
Pentamidine is also used in the treatment of African trypanosomiasis and leishmaniasis.
Storage: below 30C
Once reconstituted, solution keeps for 24 hours maximum, between 2C to 8C.

Remarks

216

Revised September 2014

PHENOBARBITAL
(Gardenal, Luminal)

Prescription under medical supervision

Therapeutic action

Anticonvulsant

Indications

Emergency treatment of :
Convulsive status epilepticus
Seizures in neonates

Presentation and route of administration

200 mg in 1 ml ampoule (200 mg/ml) for IV perfusion or deep IM injection in the absence
of venous access. DO NOT GIVE BY DIRECT RAPID IV INJECTION.

Dosage

Neonates and children under 12 years: one dose of 20 mg/kg (max. 1 g). If necessary, a
second dose of 10 mg/kg may be administered 15 to 30 minutes after the first dose (if
administered by IV infusion) or 60 minutes after the first dose (if administered by IM injection).
Children over 12 years and adults: one dose of 10 mg/kg (max. 1 g). If necessary, a second
dose of 5 to 10 mg/kg may be administered 15 to 30 minutes after the first dose.
For administration by IV infusion:
Dilute the required dose in a 100 ml pouch of 0.9% sodium chloride or 5% glucose for patients
weighing 20 kg or more and in 5 ml/kg of 0.9% sodium chloride or 5% glucose for children
weighing less than 20 kg. Administer over at least 20 minutes. Do not administer more than
1 mg/kg/minute.
If the required dose is less than 1 ml, use a 1 ml syringe graduated 0.01 ml.
For administration by IM injection:
May be used undiluted. If the required dose is less than 1 ml, use a 1 ml syringe graduated
0.01 ml.

Contra-indications, adverse effects, precautions

Do not administer in patients with severe respiratory depression.


Do not administer by SC route (risk of necrosis).
Administer with caution in the elderly, children and patients with respiratory insufficiency.
May cause :
dose dependant respiratory depression (enhanced by diazepam), drowsiness; cutaneous
and allergic reactions, sometimes severe.
hypotension, apnoea, laryngospasm, shock, especially if administered too rapidly by IV
route.
Monitor closely respiration and blood pressure during and after administration. Ensure
that respiratory support (Ambu bag via face mask or intubation) and IV solutions for fluid
replacement are ready at hand.
Avoid combination with central nervous system depressants (opioid analgesics, sedatives,
H1 antihistamines, etc.).
Pregnancy and breast-feeding: risks linked to status epilepticus appear greater than risks linked to
phenobarbital.

Remarks

Do not mix with other drugs in the same syringe or infusion bag.
Phenobarbital is subject to international controls: follow national regulations.
Storage: no special temperature requirements

217

PHYTOMENADIONE = VITAMIN K1
Prescription under medical supervision
Vitamin, anti-haemorrhagic

Therapeutic action

Prophylaxis and treatment of haemorrhagic disease of the newborn

Indications

2 mg ampoule (10 mg/ml, 0.2 ml), for oral administration, IM or slow IV injection
10 mg ampoule (10 mg/ml, 1 ml), for oral administration, IM or slow IV injection

Presentation and route of administration

Prophylaxis of haemorrhagic disease of the newborn

Dosage and duration

breastfed infants
Formula fed infants

IM route

One single dose the day of birth:


Child < 1.5 kg: 0.5 mg
Child > 1.5 kg: 1 mg

Oral route

3 doses:
2 mg the day of birth
2 mg 4 to 7 days after birth
2 mg 4 weeks after birth
2 doses:
2 mg the day of birth
2 mg 4 to 7 days after birth

Prophylaxis by oral route is effective only if all the doses are administered. Therefore, use
IM route in all newborn infants if treatment compliance cannot be guaranteed. Do not use
oral route in newborns at high risk (preterm neonates, jaundice, neonatal diseases; newborns whose mother is treated with enzyme-inducing drugs).

Treatment of haemorrhagic disease of the newborn


1 mg by IM or slow IV injection, to be repeated every 8 hours if necessary, depending on
clinical evolution and coagulation tests results.
May cause: allergic reactions, especially by IV route, haematoma at IM injection site.
Pregnancy and breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

To pregnant women taking enzyme-inducing drugs (rifampicin, phenobarbital, phenitoin,


carbamazepine), administer 10 mg/day orally for the 15 days prior to the expected date of
delivery. This maternal prevention does not change the need for IM prophylaxis in newborns at high risk.
Phytomenadione is also used for the treatment of haemorrhage due to antivitamin K agents
(warfarin). According to InR and severity of bleeding: in adults, 1 to 5 mg orally or 0.5 to
10 mg by slow IV route.
Vitamin K has no direct or immediate haemostatic action: it is not indicated for traumatic
haemorrhage.
Do not dilute or mix with other drugs in the same syringe.
Storage: below 25C

Remarks

218

POTASSIUM CHLORIDE 10% = KCL 10%


Prescription under medical supervision

Treatment of severe hypokalaemia (arrhythmia, marked muscular weakness, rhabdomyolysis


or serum potassium level 2.5 mmol/litre)

Indications

Ampoule containing 10% potassium chloride hypertonic solution (100 mg/ml, 10 ml), i.e.
1 g of potassium chloride (KCl) per 10 ml ampoule
Ionic composition:
potassium (K+): 13.4 mmol per 10 ml ampoule (13.4 mEq)
chloride (Cl): 13.4 mmol per 10 ml ampoule (13.4 mEq)
Check concentration before use: potassium chloride also comes in ampoules containing
7.5%, 11.2%, 15% and 20% solutions.
NEVER USE BY IV OR IM OR SC INJECTION. Potassium chloride must always be administered
by slow IV infusion, diluted in 0.9% sodium chloride.
For dilution:
The potassium concentration in the infusion fluid should not exceed 40 mmol/litre.
Mix thoroughly the potassium and the 0.9% sodium chloride solution by inverting at
least 5 times the infusion bottle or bag.

Presentation and route of administration

Dosage depends on the severity of hypokalaemia and the patients underlying condition. For
information:

Dosage and duration

Child over 1 month: 0.2 mmol/kg/hour for 3 hours


Each mmol of potassium is diluted in 25 ml of 0.9% sodium chloride.
Examples:
10 kg
15 kg

0.2 (mmol) x 10 (kg) = 2 mmol/hour x 3 hours = 6 mmol


6 mmol (= 4.5 ml of 10% KCl solution) diluted in 150 ml of naCl 0.9% and
administered over 3 hours
0.2 (mmol) x 15 (kg) = 3 mmol/hour x 3 hours = 9 mmol
9 mmol (= 6.5 ml of 10% KCl solution) diluted in 225 ml of naCl 0.9% and
administered over 3 hours.

Adult: 40 mmol (= 3 ampoules of 10 ml of 10% KCl) in one litre, to be administered over


4 hours. Do not exceed 10 mmol/hour.

The infusion may be repeated if severe symptoms persist or if the serum potassium level
remains < 3 mmol/litre.

Administer with caution to elderly patients.


Administer with caution and reduce the dose in patients with renal impairment (increased
risk of hyperkalaemia).
May cause:
in the event of rapid or excessive administration: hyperkalaemia, cardiac conduction
and rhythm disorders, potentially fatal;
in the event of extravasation: necrosis.
Infusion must be constantly monitored.

Contra-indications, adverse effects, precautions

A 7.5% potassium solution contains 1 mmol of K+/ml; a 11.2% solution contains 1.5 mmol of
K+/ml; a 15% solution contains 2 mmol of K+/ml; a 20% solution contains 2.68 mmol
of K+/ml.
Moderate hypokalaemia is defined as a potassium level < 3.5 mmol/litre; severe hypo kalaemia as a potassium level 2.5 mmol/litre.
Storage: below 30C

Remarks

219

PROMETHAZINE
(Phenergan)

Prescription under medical supervision

Sedating antihistamine, anti-emetic

Therapeutic action

Symptomatic treatment of allergic reactions, when oral administration is not possible


nausea and vomiting

Indications

50 mg in 2 ml ampoule (25 mg/ml) for IM injection

Presentation and route of administration

Allergic reactions
Child from 5 to 10 years: 6.25 to 12.5 mg as a single dose
Child over 10 years and adult: 25 to 50 mg as a single dose

Dosage and duration

Nausea, vomiting
Child over 12 years and adult: 12.5 to 25 mg/injection, to be repeated every 4 to 6 hours if
necessary (max. 100 mg/day)
Do not administer to patients with prostate disorders or closed-angle glaucoma and to
children less than 2 years.
Administer with caution and monitor use in patients > 60 years and in children (risk of
agitation, excitability).
May cause: drowsiness, anticholinergic effects (dry mouth, blurred vision, constipation,
tachycardia, disorders of micturition), headache, tremor, allergic reactions.
Monitor combination with CnS depressants (opioid analgesics, antipsychotics, sedatives,
antidepressants, etc.) and drugs known to have anticholinergic effects (amitryptiline,
atropine, carbamazepine, chlorpromazine, clomipramine, etc.).
Pregnancy: avoid at the end of pregnancy; no prolonged treatment.
Breast-feeding: no contra-indication; monitor the child for excessive somnolence.

Contra-indications, adverse effects, precautions

Storage: below 30C

Remarks

220

PROTAMINE
(Prosulf)

Prescription under medical supervision

neutralisation of the anticoagulant action of unfractionated heparin


Partial neutralisation of the anticoagulant action of low molecular weight heparin

Therapeutic action

Haemorrhagic syndromes resulting from accidental heparin overdosage

Indications

50 mg protamine sulfate in 5 ml ampoule (10 mg/ml) for slow IV injection


Concentration may be expressed in antiheparin units (AHU): 1000 AHU = 10 mg.

Presentation and route of administration

Depends on the amount of heparin to be neutralised.

Dosage

Heparin overdosage
If administered between 0 and 30 minutes after the heparin injection, 1 mg of protamine
sulfate (100 AHU) neutralises 100 units of heparin.
If more than 30 minutes have elapsed since the heparin injection, the dose of protamine to
be given should be one half the dose of heparin injected.
Do not administer more than 50 mg for any one dose.
Nadroparin overdosage
1 mg of protamine sulfate (100 AHU) neutralises 100 units of nadroparin. The dose of
protamine to be given is equal to that of the nadroparin injected.

Duration: according to clinical response. Monitor coagulation parameters.

May cause: hypotension, bradycardia and dyspnoea; allergic reactions, notably in diabetics
treated by protamine-insulin.
If excessive doses are used, haemorrhage may persist or reappear, as protamine sulfate
itself has some anticoagulant activity.
Administer by very slow IV (over 10 minutes) in order to reduce risks of hypotension and
bradycardia.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

In the case of nadroparin overdose, it is recommended to administer 1 or 2 units of fresh


whole blood at the same time to counteract its activity against Factor Xa.
Anticoagulant effect of protamine may vary according to the origin of the heparin: follow
manufacturer's recommendations.
Protamine sulfate may be used to neutralize the effect of heparin before surgery.
Storage: to be kept refrigerated (2C to 8C)

Remarks

221

QUININE
Prescription under medical supervision
Antimalarial

Therapeutic action
Treatment of severe falciparum malaria

Indications

600 mg of quinine dihydrochloride in 2 ml ampoule (300 mg/ml), to be diluted in 5% glucose,


for slow infusion. nEVER FOR IV InjECTIOn.

Presentation and route of administration

The dosage is expressed in terms of salt; it is the same for quinine dihydrochloride or for
quinine formate:
Child and adult:
loading dose: 20 mg/kg administered over 4 hours, then keep the vein open with an
infusion of 5% glucose over 4 hours
maintenance dose: 8 hours after the start of the loading dose, 10 mg/kg every 8 hours
(alternate quinine over 4 hours and 5% glucose over 4 hours)
For adults, administer each dose of quinine in 250 ml. For children under 20 kg, administer
each dose of quinine in a volume of 10 ml/kg.
Do not administer a loading dose to patients who have received oral quinine, mefloquine
or halofantrine within the previous 24 hours: start with maintenance dose.

Dosage

As soon as the patient is able to take oral treatment, administer either oral quinine to complete
7 days of treatment or an artemisinin-based combination (if patient developed neurological
signs during the acute phase, do not use the combination artesunate-mefloquine).

Duration

May cause: hypoglycaemia; auditory and visual disturbances, cardiac disorders (especially in
the event of overdose), hypersensitivity reactions, cardiac depression if injected undiluted
by direct IV route.
In patients with acute renal failure, reduce the dose by one-third if the parenteral treatment
lasts more than 48 hours.
Monitor blood glucose (reagent strip test).
Do not combine with chloroquine or halofantrine.
Do not administer simultaneously with mefloquine (risk of seizures, cardiac toxicity).
Administer mefloquine 12 hours after the last dose of quinine.
Pregnancy: no contra-indication. The risk of quinine-related hypoglycaemia is very high in pregnant
women.
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

10 mg quinine dihydrochloride = 8 mg quinine base.


Administration by IM deep injection (into the anterior thigh only) is possible when infusion
cannot be performed (e.g. before transferring a patient). However this may cause numerous
complications. Doses are the same as for the IV route. Quinine should be diluted (1/2 or 1/5).
For the loading dose, administer half the dose into each thigh.
In certain regions of South-East Asia, quinine is combined with doxycycline or clindamycin,
due to a reduction in P. falciparum sensitivity to quinine.
Storage: below 30C

Remarks

222

Revised May 2015

SALBUTAMOL = ALBUTEROL

Therapeutic action

Prescription under medical supervision

Uterine relaxant

Indications

Threatened premature labour (preferably use nifedipine for this indication)

Presentation and route of administration

0.5 mg in 1 ml ampoule (0.5 mg/ml) for IV infusion

Dosage

Dilute 5 mg (10 ampoules of 0.5 mg) in 500 ml of 5% glucose or 0.9% sodium chloride to
obtain a solution of 10 micrograms/ml.
Start infusion at the rate of 15 to 20 micrograms/minute (30 to 40 drops/minute).
If contractions persist, increase the rate by 10 to 20 drops/minute every 30 minutes until
uterine contractions cease. Do not exceed 45 micrograms/minute (90 drops/minute).
Continue for one hour after contractions have ceased, then reduce the rate by half every
6 hours.

Duration

48 hours maximum

Contra-indications, adverse effects, precautions

Do not administer to patients with pre-eclampsia, eclampsia, uterine haemorrhage, intrauterine infection, intra-uterine foetal death, placenta praevia, placental abruption, rupture
of membranes, multiple pregnancy, severe cardiopathy.
Administer with caution to patients with diabetes, hyperthyroidism.
Do not combine with nifedipine.
May cause: pulmonary oedema, myocardial ischemia, foetal and maternal tachycardia,
hypotension, tremor, headache, hypokalaemia, hyperglycaemia.
Monitor maternal pulse regularly. Reduce the infusion rate in the event of maternal tachycardia (> 120/minute).
Pregnancy: no contra-indication
Breast-feeding: avoid

Remarks

220

Use salbutamol within 24 hours of mixing with infusion fluid.


Do not mix with other drugs in the same infusion fluid.
Also comes in 5 ml ampoule containing 0.25 mg (0.05 mg/ml).
Storage: below 25C

SODIUM BICARBONATE 8.4%


Prescription under medical supervision
Severe metabolic acidosis

Indications

10 ml or 20 ml ampoule

Presentation

Sodium bicarbonate in hypertonic solution: 8.4 g per 100 ml


Ionic composition: sodium (na+) : 10 mmol (10 mEq) per 10 ml ampoule
bicarbonate : 10 mmol (10 mEq) per 10 ml ampoule

Composition

Do not use in case of alkalosis or respiratory acidosis.


Do not administer hypertonic solutions by IM or SC route. Administer under close medical
supervision, by slow direct IV injection diluted in 5% glucose or by continuous infusion in
5% glucose.
Contains a high concentration of bicarbonate and sodium ions. Its use is rarely justified in
case of metabolic acidosis caused by dehydration. Inaccurate administration may induce
hypernatraemia and hypokalaemia.
Do not add: penicillins, chloramphenicol, aspirin, atropine, calcium, insulin, vitamins, etc.
to sodium bicarbonate solution.
Storage: below 30C

Contra-indications, adverse effects, precautions, remarks

224

SPECTINOMYCIN
(Kempi, Stanilo, Trobicin)

Prescription under medical supervision

Cephalosporins are the first choice treatment of gonococcal infections. Spectinomycin may be used as an
alternative, when cephalosporins are not available or
are contraindicated.

Antibacterial (group of aminoglycosides)

Therapeutic action

Second choice treatment of gonococcal infections

Indications

Powder for injection in 2 g vial, to be dissolved with the diluent supplied by the manufacturer
(3.2 ml ampoule of water for injection with benzyl alcohol), for IM injection

Presentation and route of administration

Anogenital gonococcal infection and gonococcal conjunctivitis


Adult: 2 g as a single dose (a dose of 4 g may be required, divided between two sites)

Dosage and duration

Disseminated gonococcal infection


Adult: 4 g/day in 2 divided doses for 7 days

May cause: nausea, dizziness, fever and chills, urticaria; pain at injection site.
Pregnancy: CONTRA-INDICATED (safety is not established)
Breast-feeding: no contra-indication for a single dose treatment

Contra-indications, adverse effects, precautions

Administer a concurrent anti-chlamydia treatment to patients with gonococcal infections


(co-infections are frequent).
Spectinomycin is poorly effective against pharyngeal gonococcal infections.
For the treatment of neonatal gonococcal conjunctivitis, use cephalosporins.
Shake well prior to withdrawal medication and use a 19-gauge needle.
Do not mix with other drugs in the same syringe.
Storage: below 30C

Remarks

225

STREPTOMYCIN = S
Prescription under medical supervision
Therapeutic action

Antibacterial with bactericidal activity (group of aminoglycosides)

Indications

Tuberculosis, in combination with other antituberculous antibacterials

Presentation and route of administration

Powder for injection, vial containing 1 g of streptomycin base, to be dissolved in 5 ml of


water for injection, for IM injection. DO NOT ADMINISTER BY IV INJECTION.

Dosage

Child over 30 kg and adult: 15 mg/kg (12 to 18 mg/kg/day) once daily; maximum 1 g/day
Weight

30 to 33 kg
34 to 40 kg
41 to 45 kg
46 to 50 kg
51 to 70 kg
> 70 kg

Duration: according to protocol

1 g vial to be dissolved in 5 ml
(200 mg/ml)

Dose in mg

Dose in ml

600 mg

3 ml

500 mg

2.5 ml

700 mg

3.5 ml

900 mg

4.5 ml

800 mg
1000 mg

4 ml
5 ml

Contra-indications, adverse effects, precautions

Do not administer to patients with hypersensitivity to aminoglycosides.


Administer with caution to patients with pre-existing renal, vestibular or auditory problems.
Reduce the dose in patients with renal impairment (12 to 15 mg/kg/injection 2 or 3 times
per week).
Reduce the dose to 500-750 mg/day in patients over 60 years.
May cause: vestibular and auditory damage, renal impairment, electrolyte imbalance and
hypersensitivity reactions.
Stop treatment in the event of dizziness, persistent giddiness, tinnitus or hearing defects.
Pregnancy: CONTRA-INDICATED
Breast-feeding: no contra-indication

Remarks

Streptomycin is included in the WHO Group 2 antituberculous agents.


Streptomycin is also used in the treatment of:
Brucellosis: 15 mg/kg once daily in children and 1 g once daily in adults, for 2 weeks, in
combination with doxycycline for 6 weeks.
Plague: 30 mg/kg/day in children and 2 g/day in adults, divided into 2 injections given
at 12 hour-intervals, for 10 days.
Storage: below 25C
Reconstituted solution can be kept 24 hours maximum, below 25C and protected from light.

226

SURAMIN
(Germanin)

Prescription under medical supervision

Trypanocide

Therapeutic action
Haemolymphatic stage of African trypanosomiasis due to T. b. rhodesiense

Indications

Powder for injection in 1 g vial, to be dissolved in 10 ml of water for injection to obtain a


10% solution, for slow IV injection (or slow infusion in 500 ml of 0.9% naCl). nEVER by IM
OR SC InjECTIOn.

Presentation and route of administration

Patients must be treated in hospital, under close medical supervision.


Child and adult: 4 to 5 mg/kg by slow IV at D1 (test dose) then, in the absence of reaction
after the test dose, 20 mg/kg by slow IV at D3, D10, D17, D24 and D31 (max. 1 g/injection)

Dosage

Do not administer in patients with severe renal or hepatic disease.


May cause:
anaphylactic reaction: administer a test dose before starting treatment. In the event of
anaphylactic reaction, the patient should never receive suramin again.
proteinuria (renal toxicity), diarrhoea, haematological disorders (haemolytic anaemia,
agranulocytosis, etc.), eye disorders (photophobia, lachrymation), neurological disorders
(paraesthesia, hyperaesthesia of the palms and soles, polyneuropathy), high fever, skin
eruption, malaise, intense thirst, polyuria.
local inflammation and necrosis when administered by IM or SC injection.
before each injection, check for proteinuria: moderate proteinuria is common at the start of
treatment, heavy proteinuria calls for dose reduction and modification of treatment
schedule; in the event of persisting heavy proteinuria, treatment should be discontinued.
Ensure that the patient is well hydrated.
Pregnancy: although suramin is toxic, it is recommended to treat pregnant women with rhodesiense
trypanosomiasis at the haemolymphatic stage. Suramin is also used at the meningoencephalitic stage
until the woman can be given melarsoprol after delivery, as melarsoprol is contra-indicated during
pregnancy.

Contra-indications, adverse effects, precautions

Suramin is not administered at the meningoencephalitic stage (except in pregnant women)


as it poorly penetrates into the cerebrospinal fluid.
Due to its toxicity, suramin is no longer used for the treatment of onchocerciasis.
Storage:

Remarks

227

THIAMINE = VITAMIN B1
(Benerva, Betaxin)

Vitamin

Therapeutic action
Initial treatment of severe thiamine deficiency: severe acute forms of beriberi, neurological
complications of chronic alcoholism (severe polyneuritis, Wernickes encephalopathy,
Korsakoff syndrome)

Indications

100 mg thiamine hydrochloride in 2 ml ampoule (50 mg/ml) for IM or very slow IV injection

Presentation and route of administration

Infantile beriberi
25 mg by IV injection then, 25 mg by IM injection once or twice daily then, change to oral
route (10 mg/day) as soon as symptoms have improved.

Dosage and duration

Acute beriberi
50 mg as a single IM injection then change to oral treatment (150 mg/day in 3 divided
doses until symptoms improve then, 10 mg once daily)
or, depending on severity, 150 mg/day in 3 IM injections for a few days then change to oral
route (10 mg/day).
Wernickes encephalopathy, Korsakoff syndrome
250 mg once daily by IV injection until the patient can take oral treatment. Higher initial
doses may be required during the first 12 hours.

May cause: hypotension; anaphylactic reaction, especially when injected IV (inject very
slowly over 30 minutes).
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Thiamine is also called aneurine.


Injectable thiamine is not included in the WHO list of essential medicines.
Storage:

Remarks

228

TRAMADOL
(Tramal, Zamadol, Zydol)

Prescription under medical supervision

Centrally acting analgesic (weak opioid, serotonin-norepinephrine reuptake inhibitor)

Therapeutic action

Moderate acute pain

Indications

100 mg ampoule (50 mg/ml, 2 ml) for SC, IM, slow IV injection or infusion

Presentation and route of administration

Child over 6 months: 2 mg/kg/injection every 6 hours


Adult: 50 to 100 mg/injection every 4 to 6 hours, without exceeding 600 mg/day

Dosage

Duration: change to oral route as soon as possible.

Do not administer in the event of severe respiratory depression and to patients that risk
seizures (e.g. epilepsy, head injury, meningitis).
May cause:
dizziness, nausea, vomiting, drowsiness, dry mouth, sweating;
rarely: allergic reactions, seizures, confusion;
exceptionally: withdrawal symptoms; respiratory depression in the event of overdosage.
Do not combine with opioid analgesics, including codeine.
Avoid combination with carbamazepine, fluoxetine, chlorpromazine, promethazine,
clomipramine, haloperidol, digoxin.
Reduce doses (1 mg/kg) and administer every 12 hours in elderly patients and in patients
with severe renal or hepatic impairment (risk of accumulation).
For IV administration, it is better to use tramadol by infusion over 20-30 minutes rather
than by IV injection, in order to limit adverse effects.
Pregnancy and breast-feeding: no contra-indication. The child may develop adverse effects (drowsiness)
when the mother receives tramadol at the end of the 3rd trimester and during breast-feeding. In these
events, administer with caution, for a short period, at the lowest effective dose, and monitor the child.

Contra-indications, adverse effects, precautions

Tramadol is approximately 10 times less potent than morphine.


In some countries, tramadol is on the list of narcotics: follow national regulations.
Storage:

Remarks

229

Infusion fluids

Use of infusion fluids


Volume expanders

Glucose 5% = dextrose 5%

Glucose 10% = dextrose 10%


Modified fluid gelatin
Polygeline

Ringer Lactate (Hartmanns solution)


Sodium chloride 0.9%

Use of infusion fluids

Choice of infusion fluids according to indications


3 kinds of infusion fluids should be available:

For IV rehydration: Ringer Lactate is the most suitable.

For administration of IV drugs: 5% glucose solution and 0.9% sodium chloride solution are
the most suitable.
For volume expansion: see table next page.

Precautions for the use of infusion fluids

Carefully read the labels on the infusion bottle to avoid mistakes.

Indicate on the label any drugs added to the infusion as well as the patients name and/or
bed number.
If drugs are added to the intravenous fluid, think of the risks of:
physical and chemical incompatibilities,
microbial contamination: aseptic technique.

Examine each bottle against the light to check clearness. Discard any bottles that show particles
in suspension or cloudiness.

233

Polygeline
Modified fluid
gelatin

COLLOIDS

Ringer Lactate
NaCl 0.9 %

CRISTALLOIDS

2 to 3 hours

1 to 2 hours

Duration*

1 to 1.5 times
the estimated
fluid loss

3 times
the estimated
fluid loss

Volume

According to
patients
condition

According to
patients
condition

Dosage

Contraindications

- Hypovolaemia - Allergy to
gelatins

- Hypovolaemia - None
- Prevention of
hypotension
induced by
spinal
anaesthesia

Indications

Volume expanders

For more information, refer to relevant fact-sheet.

* Length of time during which the fluid remains in the intravascular compartment after infusion.

234

- Relatively good
volume expansion

- Free from adverse


effects
- Inexpensive

Advantages

- Allergic reactions
- Expansion of short
duration
- Expensive

- Large amounts to
be infused rapidly
- Expansion of short
duration

Disadvantages

GLUCOSE 5% = DEXTROSE 5%

Vehicle for the administration of parenteral drugs

Indications

5% isotonic glucose solution (50 mg of glucose/ml) for infusion


500 ml and 1000 ml bottles or bags

Composition and presentation

Do not use glucose solution for the administration of hydralazine (incompatibility, rapid
degradation of hydralazine): use only 0.9% sodium chloride or Ringer Lactate solution.
Other drugs such as amoxicillin + clavulanic acid, aciclovir, phenytoin, bleomycin or
chloroquine must also be administered in 0.9% sodium chloride solution.
Amoxicillin diluted in 5% glucose must be administered in less than one hour. If infusion
over more than one hour is required, use 0.9% sodium chloride.

Contra-indications, adverse effects, precautions

This solution does not contain electrolytes or lactate. Its use is not recommended for the IV
treatment of dehydration. Use Ringer Lactate or 0.9% sodium chloride solutions.
Low nutritional value: 200 kcal/litre.
Storage: below 30C

Remarks

235

GLUCOSE 10% = DEXTROSE 10%


Prescription under medical supervision
Emergency treatment of severe hypoglycaemia

Indications

10% hypertonic glucose solution (100 mg of glucose/ml) for slow IV injection or infusion
500 ml bottle or bag

Composition and presentation

Severe hypoglycaemia
Child and adult: 5 ml/kg by very slow IV injection (over 5 minutes) or IV infusion
Check blood glucose level 30 minutes after injection. If blood glucose level is still < 3 mmol/l
or < 55 mg/dl, administer a second dose or give oral glucose, according to the patient
clinical condition.

Dosage and duration

Neonatal hypoglycaemia
5 ml/kg/hour by IV infusion
In the event of loss of consciousness or seizures, give in addition a loading dose of
2.5 ml/kg by very slow IV infection (over 5 minutes).
Do not administer by IM or SC route.

Contra-indications, adverse effects, precautions


If ready-made 10% glucose solution is not available: add 10 ml of 50% glucose solution per
100 ml of 5% glucose solution to obtain a 10% glucose solution.
10% glucose solution may be used as vehicle for administration of the loading dose of IV
quinine in order to prevent hypoglycaemia. The following doses are administered in 5%
glucose solution.
Nutritional value: 400 kcal/litre.
Storage: below 30C

Remarks

236

MODIFIED FLUID GELATIN (Gelofusine, Plasmion...)


and POLYGELINE (Haemaccel)
solution for INFUSION

Prescription under medical supervision

Colloidal plasma substitute

Therapeutic action

Fluid replacement in hypovolaemic shock (haemorrhagic shock, septic shock)

Indications

500 ml plastic bottle or bag

Presentation

Varies according to the manufacturer. Example:

Composition

Modified fluid gelatin


Polygeline

Sodium (Na+)

Potassium (K+)

Calcium (Ca++)
Chloride (Cl)

Magnesium (Mg++)
Lactate

Plasmion

Haemaccel

35 g/litre

30 g/litre

150 mmol (150 mEq)


5 mmol (5 mEq)

145 mmol (145 mEq)

5.10 mmol (5.10 mEq)

6.25 mmol (12.50 mEq)

1.5 mmol (3 mEq)

100 mmol (100 mEq)


30 mmol (30 mEq)

145 mmol (145 mEq)

Adjust dosage according to the patients haemodynamic status.


In the event of haemorrhage, replace the lost volume by the same volume of plasma
substitute.

Dosage

May cause: allergic reactions, possibly severe (anaphylactic shock).


Pregnancy: CONTRA-INDICATED: risk of maternal anaphylactic reaction with serious consequences
for the foetus. Use Ringer lactate.

Contra-indications, adverse effects, precautions

Do not add any drugs to the bottle.


When plasma substitutes are not available, use Ringer lactate (giving 3 times the lost blood
volume).
Storage: below 25C

Remarks

237

RINGER LACTATE = COMPOUND SODIUM LACTATE


= Hartmanns solution
isotonic solution for INFUSION

Severe dehydration
Hypovolaemia (trauma, surgery, anaesthesia...)

Indications

500 ml and 1000 ml bottles or bags

Presentation

Varies with manufacturer.


Most frequent ionic composition per litre:
sodium (Na+): 130.50 mmol (130.50 mEq)
4.02 mmol (4.02 mEq)
potassium (K+):
++
0.67 mmol (1.35 mEq)
calcium (Ca ):
109.60 mmol (109.60 mEq)
chloride (Cl):
lactate:
28.00 mmol (28.00 mEq)

Composition

Isotonic solution. Does not contain glucose.

In cases of metabolic alkalosis, diabetes, severe hepatic failure, head injury: isotonic solution of NaCl 0.9% is preferred.
Ringer Lactate provides appropriate amounts of sodium and calcium. It contains lactate
which is converted to bicarbonate for correction of metabolic acidosis when it exists (if
haemodynamic and liver function are normal). WARNING, SOME COMMERCIALLY AVAILABLE
SOLUTIONS DO NOT CONTAIN LACTATE.
It contains 4 mEq of potassium/litre, which is sufficient for short-term use. For prolonged
use (after 2 to 3 days), addition of potassium chloride is necessary: 1 or 2 g per litre = one
to two 10 ml ampoules of KCL 10%/litre.
For moderate and mild dehydration, administer oral rehydration salts (ORS).
For correction of hypovolaemia due to haemorrhage; administer 3 times the lost volume
only if:
cardiac and renal function are not impaired,
blood loss does not exceed 1500 ml in adults.
May be used to prevent hypotension induced by spinal anaesthesia.
Storage: below 30C

Contra-indications, adverse effects, precautions, remarks

238

SODIUM CHLORIDE 0.9% = NaCl = Physiological saline

Vehicle for the administration of parenteral drugs


Fluid replacement

Indications

Isotonic solution of sodium chloride (0.9 g per 100 ml) for infusion
Ionic composition: sodium (Na+): 150 mmol per litre (150 mEq)
chloride (Cl): 150 mmol per litre (150 mEq)
250 ml and 1000 ml bottles or bags

Composition and presentation

Use with caution in patients with hypertension, heart failure, oedema, ascites due to
cirrhosis, renal impairment and other conditions associated with sodium retention.
May cause: pulmonary oedema in the event of too rapid infusion or infusion of excessive
amounts.
Do not use as vehicle for the administration of amphotericin B (incompatibility): use only
5% glucose solution.

Contra-indications, adverse effects, precautions

For correction of hypovolaemia due to haemorrhage, administer 3 times the lost volume
only if:
blood loss does not exceed 1500 ml in adults,
cardiac and renal function are not impaired.
0.9% sodium chloride solution may be used to prevent hypotension induced by spinal
anaesthesia.
This solution contains neither potassium nor lactate. In case of severe dehydration, use
Ringer Lactate. If Ringer Lactate is not available, add KCl (2 g/l) + NaCl (4 g/l) to 5% glucose.
For external use: sterile 0.9% sodium chloride solution is used for cleansing of non-infected
wounds, wound irrigation, eye cleansing (conjunctivitis, eye irrigations), nasal lavage in
the event of obstruction, etc.
Storage: below 30C

Remarks

239

Vaccines, immunoglobulins
and antisera
Antituberculous vaccine (BCG)

Diphtheria-Tetanus-Pertussis vaccine (DTP)


Hepatitis B vaccine

Japanese encephalitis vaccine


Measles vaccine

Meningococcal vaccine A + C

Meningococcal vaccine A + C + W135


Oral antipoliomyelitis vaccine (OPV)
Rabies vaccine

Human rabies immunoglobulin (HRIG)


Tetanus vaccine (TT)

Human tetanus immunoglobulin (HTIG)


Tetanus antitoxin (equine)
Yellow fever vaccine

ANTITUBERCULOUS VACCINE = BCG VACCINE

Prevention of tuberculosis

Indications

Live attenuated bacterial vaccine


Powder for injection in multidose vial, to be dissolved with the entire vial of the diluent
supplied by the manufacturer, for intradermal injection into the external face of the left
upper arm

Composition, presentation and route of administration

Child: 0.05 ml as a single dose as soon after birth as possible


If child is over one year old: 0.1 ml as a single dose

Dosage and vaccination schedule

Do not administer to patients with immunodeficiency (symptomatic HIV infection,


immunosuppressive therapy, etc.) and malignant haemopathy.
Vaccination should be postponed in the event of evolutive extensive dermatosis, acute
complicated malnutrition (vaccine should be given just before the child is discharged from
the nutrition centre) and severe acute febrile illness (minor infections are not contraindications).
May cause:
normal local reaction 2 to 4 weeks after injection: papule which changes to an ulcer, that
usually heals spontaneously (dry dressing only), leaving a permanent scar;
occasionally: persistent ulcer with serous discharge up to 4 months after injection,
non-suppurative adenitis, keloid formation, abscess at the injection site;
exceptionally: suppurative lymphadenitis, osteitis.
Clean the injection site with boiled and cooled water and allow drying. Do not use
antiseptics (risk of inactivation of live vaccine).
Do not mix with other vaccines in the same syringe (inactivation of vaccines).
If administered simultaneously with EPI vaccines, use different syringes and injection sites.
Pregnancy: CONTRA-INDICATED
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Inject the vaccine in the same place for each child to make it easy to find the BCG scar
subsequently.
If the injection is correctly performed an orange-skin papule, measuring 5-8 mm in
diameter, should appear at the injection site.
Duration of protection is not known, and decreases over time.
Storage:
Powder: between 2C and 8C. Freezing is possible but unnecessary.
Diluent: a cold chain is not required for storage. However, at least 12 hours before reconstitution
of the vaccine, the diluent must be refrigerated between 2C and 8C so that the diluent and
lyophilised powder are at the same temperature: a temperature difference during reconstitution
may reduce vaccine efficacy. Do not freeze.
Reconstituted vaccine: between 2C and 8C for 4 hours maximum.

Remarks

243

DIPHTHERIA-TETANUS-PERTUSSIS VACCINE (DTP)

Prevention of diphtheria, tetanus and pertussis in children under 7 years (primary vaccination)

Indications

Trivalent vaccine combining diphtheria toxin, tetanus toxin and whole-cell (DTwP) or
acellular (DTaP) pertussis vaccine
Suspension for injection in multidose vial, for IM injection into the anterolateral part of the
thigh

Composition, presentation and route of administration

Child: 0.5 ml/injection


3 injections in infancy (age < 1 year), with an interval of 4 weeks between each injection. It
is recommended to administer the 1st dose at 6 weeks of age, the 2nd dose at 10 weeks of age
and the 3rd dose at 14 weeks of age. If a child has not been vaccinated at 6 weeks of age, start
vaccination as soon as possible.
For booster doses, use DTP or DT or Td vaccine, depending on age.

Dosage and vaccination schedule

Do not administer in the event of significant reactions to a previous dose of DTP vaccine or
evolving neurological disease (encephalopathy, uncontrolled epilepsy): in both cases, use
DT vaccine.
Vaccination should be postponed in the event of severe acute febrile illness (minor infections
are not contra-indications).
Do not administer into the gluteal region.
May cause:
mild reactions at the injection site: swelling, redness and pain;
general reactions: fever within 24 hours after injection;
rarely: anaphylactic reactions, seizures.
Respect an interval of 4 weeks between each dose.
Shake before use to homogenise the vaccine.
Do not mix with other vaccines in the same syringe (inactivation of vaccines).
If administered simultaneously with EPI vaccines, use different syringes and injection sites.

Contra-indications, adverse effects, precautions

If the vaccination is interrupted before the complete series has been administered, it is not
necessary to start again from the beginning. Continue the vaccination schedule from where
it was interrupted and complete the series as normal.
There are two bivalent vaccines containing diphtheria and tetanus toxins:
diphtheria-tetanus vaccine (DT), used for children < 7 years for booster doses, or when
pertussis vaccine is contra-indicated, or after a significant reaction to a previous dose of
DTP;
tetanus-diphtheria vaccine with low dose diphtheria toxoid (Td), used for primary
vaccination and booster doses in children 7 years, adolescents and adults.
There is also a quadrivalent vaccine against diphtheria, tetanus, pertussis and hepatitis B.
There is also a pentavalent vaccine against diphtheria, tetanus, pertussis, hepatitis B and
Haemophilus influenzae.
Storage: between 2C and 8C. Do not freeze.

Remarks

244

HEPATITIS B VACCINE

Prevention of hepatitis B

Indications

There are 2 types of vaccines: recombinant vaccines (Engerix B, GenHevac B,


HBvaxpro, etc.) and human plasma-derived vaccines (Heptavax, etc.)
Solution for injection, in single-dose syringe or multidose vial, for IM injection into the
deltoid muscle (into the anterolateral part of the thigh in children under 2 years)

Composition, presentation and route of administration

Dosage varies according to age and type of vaccine used: follow manufacturer's instructions.

Dosage and vaccination schedule

Standard schedule
Newborns and infants:
In countries where perinatal infection is common: one injection after birth, then at 6 and
14 weeks
Where perinatal infection is less common: one injection at 6, 10 and 14 weeks
Children, adolescents, adults:
Schedule 0-1-6: 2 injections 4 weeks apart, then a 3rd injection 5 months after the 2nd injection
Accelerated schedules, when rapid protection is required (imminent departure in highly endemic
areas, post-exposure prophylaxis)
Schedule D0-D7-D21: 3 injections administered during the same month, then a 4th injection
one year after the 1st injection
Schedule 0-1-2-12: 3 injections 4 weeks apart, then a 4th injection one year after the
1st injection

Do not administer to patients with hypersensitivity to any component of the vaccine, or


history of an allergic reaction to a previous injection. Vaccination should be postponed in the
event of severe acute febrile illness (minor infections are not contra-indications).
Do not administer into the gluteal region (diminished antibody response to vaccine).
In patients with multiple sclerosis, assess the benefit-risk balance of vaccination.
May cause:
minor local or general reactions (pain or redness at injection site, fever, headache,
myalgia, etc.),
very rarely: anaphylactic reaction, serum disease, lymphadenopathy, peripheral neuropathy.
Shake before use to homogenise the vaccine.
Do not mix with other vaccines in the same syringe (inactivation of vaccines).
If administered simultaneously with EPI vaccines, use different syringes and injection sites.
Pregnancy: only administer if there is a high risk of contamination
Breast-feeding: no contra-indication

Contre-indications, effets indsirables, prcautions

Immunity develops 1 to 2 months after the 3rd injection. Vaccine efficacy is > 80%.
If the vaccination schedule is interrupted before the complete series has been administered,
it is not necessary to start again from the beginning. Continue the vaccination schedule
from where it was interrupted and complete the series as normal.
SC route may be used, only if IM route is contra-indicated.
Storage: between 2C and 8C - Do not freeze.

Remarks

245

JAPANESE ENCEPHALITIS VACCINE


(Je-Vax)

Prevention of Japanese encephalitis:


in children from 1 year and adults in endemic countries (rural areas of Southeast and
Southwest Asia and Western Pacific countries)
in travellers spending more than 1 month in endemic countries, in rural areas and
during the wet season

Indications

Inactivated virus vaccine


Powder for injection in single-dose vial, to be dissolved with the entire vial of the diluent
supplied by the manufacturer, for SC injection

Composition, presentation and route of administration

Child from 1 to 3 years: 0.5 ml/injection


Child over 3 years and adult: 1 ml/injection
There are several vaccination schedules. For information, for travellers:
3 injections on Day 0, Day 7 and Day 28; a booster dose every 3 years if risk persists.
An accelerated schedule is possible (3 doses on Day 0, Day 7 and Day 14) but this is likely to
result in lower antibody levels than the standard schedule.
The 3rd dose should be given at least 10 days before departure to ensure an adequate immune
response and access to medical care in the event of adverse reactions.

Dosage and vaccination schedule

Do not administer to patients with history of an allergic reaction to a previous injection of


Japanese encephalitis vaccine.
Vaccination should be postponed in the event of severe acute febrile illness (minor infections
are not contra-indications).
May cause:
redness and swelling at the injection site;
fever, headache, chills, asthenia;
hypersensitivity reactions (urticaria, angioedema), immediate or delayed (up to 2 weeks
after injection);
rarely: encephalitis, encephalopathy.
Do not mix with other vaccines in the same syringe (inactivation of vaccines).
If administered simultaneously with EPI vaccines, use different syringes and injection sites.
Pregnancy: only administer if there is a high risk of contamination.
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Protection lasts at least 2 years after 3 doses.


Caution: there are different vaccines against EJ, with different dosages and administration
schedules (e.g. Ixiaro vaccine, suspension for injection in pre-filled syringe, administered in
2 doses (0.5 ml on D0 and D28) in adults, by IM route). For each vaccine, follow manufacturer's
instructions.
Storage:
Powder: between 2C and 8C. Do not freeze.
Diluent: a cold chain is not required for storage. However, at least 12 hours before reconstitution
of the vaccine, the diluent must be refrigerated between 2C and 8C so that the diluent and
lyophilised powder are at the same temperature: a temperature difference during reconstitution
may reduce vaccine efficacy. Do not freeze.
Reconstituted vaccine: between 2C and 8C, for 6 hours maximum.

Remarks

246

MEASLES VACCINE

Prevention of measles

Indications

Live-attenuated virus vaccine, derived from different viral strains (Schwarz, Edmonston,
CAM70, Moraten, etc.)
Powder for injection in single multidose vial, to be dissolved with the diluent supplied by
the manufacturer, for IM or SC injection into the anterolateral part of the thigh or into the
deltoid muscle

Composition, presentation and route of administration

In the EPI: one dose of 0.5 ml in children from 9 months of age.


In situations where there is high risk of infection (overcrowding, epidemics, malnutrition,
infants born to a mother with HIV infection, etc.), administer one dose from 6 months of
age and one dose from 9 months of age (respect an interval of at least 4 weeks between two
injections).
The measles control programme recommends the administration of a 2nd dose though
catch-up immunization campaigns to reach unvaccinated children or children who did not
respond to primary vaccination. Check national recommendations.

Dosage and vaccination schedule

Do not administer to patients with severe immune depression or history of an allergic


reaction to a previous injection of measles vaccine.
Vaccination should be postponed in the event of severe acute febrile illness (minor
infections are not contra-indications).
May cause:
fever, skin rash, coryza;
exceptionally: seizures, encephalitis.
Do not mix with other vaccines in the same syringe (inactivation of vaccines).
If administered simultaneously with EPI vaccines, use different syringes and injection sites.
Pregnancy and breast-feeding: this vaccination is usually not indicated in adults

Contra-indications, adverse effects, precautions

Immunity develops 10 to 14 days after injection, and lasts for at least 10 years (when
administered at 9 months).
Storage:
Powder: between 2C and 8C.
Diluent: a cold chain is not required for storage. However, at least 12 hours before reconstitution
of the vaccine, the diluent must be refrigerated between 2C and 8C so that the diluent and
lyophilised powder are at the same temperature: a temperature difference during reconstitution
may reduce vaccine efficacy. Do not freeze.
Reconstituted vaccine: between 2C and 8C for 6 hours maximum.

Remarks

247

MENINGOCOCCAL VACCINE A + C
(AC Vax, Mencevax AC, Mengivac AC)

Prevention of meningitis due to meningococci groups A and C:


in mass immunisation campaigns in the event of an outbreak due to meningococcus A
or C
in travellers spending more than 1 month in hyperendemic areas

Indications

Inactivated bacterial vaccine, polysaccharide


Powder for injection in monodose or multidose vial, to be dissolved with the entire vial of
the diluent supplied by the manufacturer, for deep SC or IM injection, into the deltoid
muscle or the anterolateral part of the thigh in children (follow manufacturer's instructions)

Composition, presentation and route of administration

Child from 2 years and adult: 0.5 ml as a single dose

Dosage and vaccination schedule

Do not administer to patients with history of an allergic reaction to a previous injection of


meningococcal vaccine.
Vaccination should be postponed in the event of severe acute febrile illness (minor infections
are not contra-indications).
May cause: mild local reaction, mild fever.
Do not mix with other vaccines in the same syringe (inactivation of vaccines).
If administered simultaneously with EPI vaccines, use different syringes and injection sites.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Immunity develops 7 to 10 days after injection, and lasts for approximately 3 years.
Storage:
Powder: between 2C and 8C.
Diluent: a cold chain is not required for storage. However, at least 12 hours before reconstitution
of the vaccine, the diluent must be refrigerated between 2C and 8C so that the diluent and
lyophilised powder are at the same temperature: a temperature difference during reconstitution
may reduce vaccine efficacy. Do not freeze.
Reconstituted vaccine: between 2C and 8C, for 6 hours maximum.

Remarks

248

MENINGOCOCCAL VACCINE A + C + W135


(Mencevax ACW)

Prevention of meningitis due to meningococci groups A, C and W135:


in mass immunisation campaigns in the event of an outbreak due to meningococcus A,
C or W135
in travellers spending more than 1 month in hyperendemic areas

Indications

Inactivated bacterial vaccine, polysaccharide


Powder for injection in multidose vial, to be dissolved with the entire vial of the diluent
supplied by the manufacturer, for SC injection only

Composition, presentation and route of administration

Child from 2 years and adult: 0.5 ml as a single dose

Dosage and vaccination schedule

Do not administer to patients with history of an allergic reaction to a previous injection of


meningococcal vaccine.
Vaccination should be postponed in the event of severe acute febrile illness (minor infections
are not contra-indications).
May cause: mild local reaction, mild fever.
Do not mix with other vaccines in the same syringe (inactivation of vaccines).
If administered simultaneously with EPI vaccines, use different syringes and injection sites.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Immunity develops 7 to 10 days after injection, and lasts for approximately 3 years.
Storage:
Powder: between 2C and 8C.
Diluent: a cold chain is not required for storage. However, at least 12 hours before reconstitution
of the vaccine, the diluent must be refrigerated between 2C and 8C so that the diluent and
lyophilised powder are at the same temperature: a temperature difference during reconstitution
may reduce vaccine efficacy. Do not freeze.
Reconstituted vaccine: between 2C and 8C, for 6 hours maximum.

Remarks

249

ORAL ANTIPOLIOMYELITIS VACCINE (OPV)

Prevention of poliomyelitis

Indications

Live-attenuated virus vaccine, trivalent (poliovirus types 1, 2 and 3)


Oral suspension in multidose vial, to be administered on the tongue, with dropper

Composition, presentation and route of administration

One dose = 2 to 3 drops depending on manufacturer.


in non endemic areas, administer 3 doses 4 weeks apart: at 6, 10 and 14 weeks of age
in endemic areas, administer 4 doses 4 weeks apart: at birth then at 6, 10 and 14 weeks of
age

Dosage and vaccination schedule

No contra-indication.
Vaccination should be postponed in the event of severe acute febrile illness (minor
infections are not contra-indications).
If a child has diarrhoea when the vaccine is administered, give the usual dose then give an
extra dose 4 weeks later.
May cause (exceptionally): paralytic poliomyelitis, encephalopathy.
Respect an interval of 4 weeks between each dose.
Pregnancy: CONTRA-INDICATED during the first trimester, except if there is a high risk of
contamination.
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Protection lasts at least 5 years after 3 doses.


Storage: between 2C and 8C
For prolonged storage: freeze (20C).

Remarks

250

Human RABIES IMMUNOGLOBULIN (HRIG)


(Imogam Rabies)

Therapeutic action

Neutralisation of rabies virus. HRIG provides passive immunization against rabies for 3 to
4 weeks.

Indications

Prevention of rabies after category III exposure (except in patients correctly vaccinated
against rabies before exposure), in combination with rabies vaccine
Prevention of rabies after category II and III exposures in immunodeficient patients (even
in patients correctly vaccinated against rabies before exposure), in combination with rabies
vaccine

Presentation and route of administration

750 UI in 5 ml ampoule (150 UI/ml), for infiltration into the wound and IM injection

Dosage and duration

Child and adult: 20 IU/kg as a single dose on D0, along with the first dose of rabies vaccine.
Infiltrate as much of the dose as possible in and around the wound(s), which has been
cleaned beforehand. Inject any residual product, using the IM route, in a different site from
that used for vaccination. In the event of multiple wounds, dilute the dose 2 to 3-fold with
sterile 0.9% NaCl to obtain a sufficient quantity to infiltrate all the sites exposed.
If HRIG is not available on D0, the first dose of rabies vaccine is administered alone. HRIG
can still be given as soon as possible within the next few days. However, HRIG is no longer
recommended when 7 or more days have elapsed since the first dose of vaccine was given,
as vaccine-induced immunity will have developed by this time.

Contra-indications, adverse effects, precautions

No contra-indication (including during pregnancy and breast-feeding).


May cause: fever, myalgia, headache, gastrointestinal disturbances; rarely: allergic and
anaphylactic reactions.
Ensure that the HRIG does not enter a blood vessel (risk of shock): aspirate prior to
injection to confirm that the needle is not in a vein.
For finger wounds, infiltrate with caution to avoid causing a compartment syndrome.
Do not administer HRIG and rabies vaccine in the same syringe and in the same injection
site.

Remarks

Immunocompetent patients are considered as correctly vaccinated against rabies if they


present a document confirming pre-exposure vaccination with 3 doses of cell culture rabies
vaccine.
Highly purified equine immune globulin derivative F(ab)2 may replace HRIG if
unavailable. The method of administration is the same but the dose is 40 IU/kg.
Storage: between 2C and 8C. Do not freeze.

251

RABIES VACCINE
(Verorab, Rabipur, Imovax Rabies)

Prevention of rabies after category II and III exposures

Indications

Inactivated virus vaccine, prepared from cell culture (CCV): purified Vero-cell vaccine
(VPCV) or purified chick embryo-cell vaccine (PCECV) or human diploid-cell vaccine
(HDCV)
Powder for injection in monodose vial, to be dissolved with the entire vial of the diluent
(0.5 ml or 1 ml) supplied by the manufacturer
HDCV (Imovax Rabies) is administered by IM route only, into the anterolateral part of the
thigh in children < 2 years and into the deltoid in children > 2 years and adults.
VPCV (Verorab) and PCECV (Rabipur) may be administered by IM route as above or by
ID route into the arm.

Composition, presentation and route of administration

The 1st dose of vaccine should be administered as soon as possible after exposure, even if
the patient seeks medical attention long after exposure (rabies incubation period may last
several months). The patient must receive all the recommended doses.
Vaccination schedules may vary from country to country, check national recommendations.
The schedule will depend on the patients vaccination status prior to exposure and the
route of administration used (follow manufacturers instructions).
Child and adult: one IM dose = 0.5 or 1 ml, depending on the vaccine used; one ID dose =
0.1 ml

Dosage and vaccination schedule

The simplest vaccination schedules endorsed by the WHO are the following:

Vaccination
status at the
time of exposure
Administration
route and
schedule

No rabies vaccination or
Incomplete vaccination or
Complete vaccination with a NTV or
Unknown vaccination status
IM

D0

2 doses*
(1 dose in each arm or thigh)

D7

1 dose

D3
D21
D28

1 dose

ID

2 doses*
(1 dose in each arm)

2 doses
(1 dose in each arm)
2 doses
(1 dose in each arm)
2 doses
(1 dose in each arm)

Complete vaccination
with a CCV
IM or ID
1 dose
1 dose

* And, depending on the category of exposure, rabies immunoglobulin as a single dose.


252

No contra-indication for post-exposure vaccination (including during pregnancy and


breast-feeding).
May cause:
benign local reactions at the injection site (pain, induration),
general reactions (fever, malaise, headache, gastrointestinal disturbances, etc.),
exceptionally: anaphylactic reaction.
For patients receiving chloroquine for prophylaxis or treatment of malaria, use IM route
only.
Do not administer corticoids concomitantly (vaccine efficacy diminished).
IM vaccination: do not administer into the gluteal region (risk of treatment failure); ensure
that the vaccine does not enter a blood vessel (risk of shock): aspirate prior to injection to
confirm that the needle is not in a vein.
ID vaccination: incorrect ID technique results in treatment failure. If correct ID technique
cannot be assured, use the IM regimen.
Do not mix with other vaccines in the same syringe.
If administered simultaneously with rabies immunoglobulin or other vaccines, use different
syringes and injection sites.

Contra-indications, adverse effects, precautions

Only patients that present a document confirming complete pre-exposure vaccination with
3 doses of a VCC are considered as correctly vaccinated.
The use of vaccines prepared from animal nerve tissue (NTVs) is not recommended.
Rabies vaccine is also used for pre-exposure vaccination in persons at high risk of infection
(prolonged stay in rabies endemic areas, professionals in contact with animals susceptible
of carrying the virus). The vaccination schedule includes 3 doses given at D0, D7 and D21
or D28. Booster doses are recommended for persons exposed to permanent or frequent
contact with the virus.
Storage:
Powder: between 2C and 8C. Do not freeze.
Diluent: a cold chain is not required for storage. However, at least 12 hours before reconstitution
of the vaccine, the diluent must be refrigerated between 2C and 8C so that the diluent and
lyophilised powder are at the same temperature: a temperature difference during reconstitution
may reduce vaccine efficacy. Do not freeze.
Reconstituted vaccine: use immediately.

Remarks

253

TETANUS VACCINE (TT)

Prevention of tetanus in wound management


Prevention of maternal and neonatal tetanus in women of childbearing age and pregnant
women

Indications

Purified tetanus toxoid


Suspension for injection in multidose vial or single-dose syringe, for IM or SC injection into
the anterolateral part of the thigh or the deltoid muscle

Composition, presentation and route of administration

0.5 ml per injection

Dosage and vaccination schedule


Prevention of tetanus in wound management
Wound risk
category
Clean, minor
wounds
All other
wounds

Complete vaccination (3 doses or more)

Incomplete vaccination
(less than 3 doses)
Time elapsed since last dose:
or no vaccination
or
unknown
vaccination status
< 5 years
5-10 years
> 10 years

No booster
required
No booster
required

No booster
required

TT
one booster
dose

TT
Start* or complete tetanus
one booster
vaccination
dose

TT
Start* or complete tetanus
one booster vaccination and administer
dose
tetanus immunoglobulin

* At least 2 doses administered 4 weeks apart, then 3 additional doses administered


according to the same protocol as that used for women of childbearing age, to ensure
longer lasting immunity.

Prevention of maternal and neonatal tetanus in women of childbearing age and pregnant women
5 doses administered according to the following protocol:
TT1

On first contact with medical service or as early in pregnancy as possible

TT3

6 to 12 months after TT2 or during subsequent pregnancy

TT2
TT4
TT5

At least 4 weeks after TT1

1 to 5 years after TT3 or during subsequent pregnancy

1 to 10 years after TT4 or during subsequent pregnancy

Pregnant women should receive at least 2 doses of tetanus vaccine administered at least
4 weeks apart, with the last dose at least 2 weeks before delivery. After delivery, continue
vaccination as described in the table above until the required five doses have been
administered.
254

Do not administer in the event of significant reactions to a previous dose of tetanus vaccine.
Vaccination should be postponed in the event of severe acute febrile illness (minor infections
are not contra-indications).
May cause: minor local reactions (redness, pain at the injection site); exceptionally,
anaphylactic reactions.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

For the prevention of tetanus in wound management, preferred vaccines are:


diphtheria-tetanus-pertussis (DTP) or diphtheria-tetanus (DT) in children < 7 years,
tetanus-diphtheria (Td) in children 7 years, adolescents and adults.
For the prevention of maternal and neonatal tetanus in women of childbearing age and
pregnant women, administer either TT vaccine or tetanus-diphtheria vaccine (Td).
Storage: between 2C and 8C. Do not freeze.

Remarks

255

Human TETANUS IMMUNOGLOBULIN (HTIG)

Neutralisation of tetanus toxin. HTIG provides passive immunization against tetanus for
3 to 4 weeks.

Therapeutic action

Prevention of tetanus in wound management, in patients non immunised or incompletely


immunised or in patients whose immunisation status is unknown, in combination with
tetanus vaccine
Treatment of clinical tetanus

Indications

Solution for injection, in 250 IU (250 IU/ml, 1 ml) or 500 IU (250 IU/ml, 2 ml) ampoule or
single-dose syringe, for IM injection. DO NOT ADMINISTER BY IV ROUTE.

Presentation and route of administration

Prevention of tetanus
HTIG is administered in the event of tetanus-prone wounds, e.g. wounds with fracture,
deep penetrating wounds, bite wounds, wounds containing foreign bodies, wounds contaminated with soil, infected wounds, extensive tissue damage (contusions, burns).
Child and adult: 250 IU as a single dose; 500 IU if more than 24 hours has elapsed
HTIG should be administered as soon as possible after injury, along with the tetanus
vaccine, in a separate syringe and injection site.

Dosage and duration

Treatment of tetanus
Neonate, child and adult: 500 IU as a single dose, to be injected into 2 different sites

Do not administer to patients with known allergy to HTIG.


May cause (very rarely): allergic reactions.
Ensure that the HTIG does not enter a blood vessel (risk of shock): aspirate prior to
injection to confirm that the needle is not in a vein.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

For minor clean wounds, tetanus vaccine is administered alone.


SC route may be used but only if IM route is contra-indicated.
Storage: between 2C and 8C. Do not freeze.

Remarks

256

TETANUS ANTITOXIN (EQUINE)


Equine tetanus antitoxin should no longer be used, as there is a risk of
hypersensitivity and serum sickness.
It should be replaced by human tetanus immunoglobulin.

Neutralisation of tetanus toxin. Tetanus antiserum provides temporary passive immunity


against tetanus for 15 days.

Therapeutic action

Prevention of tetanus in wound management, in patients non immunised or incompletely


immunised or in patients whose immunisation status is unknown, in combination with
tetanus vaccine
Treatment of clinical tetanus

Indications

Solution prepared from the serum of horses immunised against tetanus toxin
1500 IU in 1 ml ampoule, for IM injection. DO NOT ADMINISTER BY IV ROUTE.

Composition, presentation and route of administration

Prevention of tetanus
Tetanus antiserum is administered in the event of tetanus-prone wounds, e.g. wounds with
fracture, deep penetrating wounds, bite wounds, wounds containing foreign bodies,
wounds contaminated with soil, infected wounds, extensive tissue damage (contusions,
burns).
Child and adult: 1500 IU as a single dose; 3000 IU if more than 24 hours has elapsed
It is administered as soon as possible after injury, along with the tetanus vaccine, in a
separate syringe and injection site.

Dosage and duration

Treatment of tetanus
Neonate: 1500 IU as a single dose
Child and adult: 10 000 IU as a single dose

Do not administer to patients with known allergy to tetanus antiserum.


May cause: hypersensitivity reactions, anaphylactic shock, Quinke oedema; serum sickness
up to 10 days after injection.
Administer following Besredka's method: inject 0.1 ml by SC route and wait 15 minutes; if
no local or general allergic reactions occur, inject 0.25 ml by SC route and wait 15 minutes;
if no reactions, administer the injection by IM route.
Ensure that the injection does not enter a blood vessel (risk of shock): aspirate prior to
injection to confirm that the needle is not in a vein.
Pregnancy and breast-feeding: no contra-indication

Contra-indications, adverse effects, precautions

Equine tetanus antitoxin is not included in the WHO list of essential medicines.
Storage: between 2C and 8C. Do not freeze.

Remarks

257

YELLOW FEVER VACCINE

Indications

Prevention of yellow fever:


in children from 9 months of age and adults living in or travelling through endemic areas
in mass immunisation campaigns in the event of an outbreak
Live-attenuated virus vaccine
Powder for injection in multidose vial, to be dissolved with the entire vial of diluent supplied
by the manufacturer, for IM injection into the anterolateral part of the thigh in children under
2 years and SC injection into the deltoid muscle in children over 2 years and adults

Composition, presentation and route of administration

Child and adult: 0.5 ml as a single dose


In routine immunisation (EPI), the vaccine is usually administered from 9 months of age,
along with the measles vaccine.
Vaccination is contra-indicated in children less than 6 months. In children between 6 and
9 months, vaccination is only recommended in epidemics, as the risk of virus transmission
may be very high.

Dosage and vaccination schedule

Do not administer to patients with history of an allergic reaction to a previous injection of


yellow fever vaccine, true allergy to egg, immunodeficiency (e.g. symptomatic HIV infection,
immunosuppressive therapy).
Vaccination should be postponed in the event of severe acute febrile illness (minor infections
are not contra-indications).
May cause:
minor reactions: mild fever, headache, myalgia;
severe reactions (exceptionally): hypersensitivity reactions, encephalitis (especially in
children < 9 months and adults > 60 years), multiple organ failure (especially in adults
> 60 years).
Do not mix with other vaccines in the same syringe (inactivation of vaccines).
If administered simultaneously with EPI vaccines, use different syringes and injection sites.
Pregnancy: not recommended. However, given the severity of yellow fever, the vaccine is administered
when the risk of contamination is very high (epidemics, unavoidable travel to regions of high
endemicity).
Breast-feeding: no contra-indication

Contraindications, adverse effects, precautions

Immunity develops approximately 10 days after injection, and lasts for at least 10 years.
Storage:
Powder: between 2C and 8C.
Diluent: a cold chain is not required for storage. However, at least 12 hours before reconstitution
of the vaccine, the diluent must be refrigerated between 2C and 8C so that the diluent and
lyophilised powder are at the same temperature: a temperature difference during reconstitution
may reduce vaccine efficacy. Do not freeze.
Reconstituted vaccine: between 2C and 8C, for 6 hours maximum.

Remarks

258

Drugs for external use,


antiseptics and disinfectants
Aciclovir eye ointment
Alcohol-based solution or gel
Artesunate rectal
Benzoic acid + salicylic acid
Benzyl benzoate
Calamine
Chlorhexidine
Chlorine-releasing compounds
Ciprofloxacine ear drops
Clotrimazole
Dinoprostone
Ethanol
Ethyl alcohol
Fluorescein
Gentian violet
Iodine, alcoholic solutions
Malathion
Merbromin
Methylrosanilinium chloride
Miconazole
Mupirocin
NaDCC
Nystatin
Oxybuprocaine eye drops
Permethrin 1%
Permethrin 5%
Pilocarpine eye drops
Podophyllotoxin
Podophyllum resin
Polyvidone iodine aqueous solution
Polyvidone iodine scrub solution
Potassium permanganate
Silver sulfadiazine
Sodium dichloroisocyanurate
Sodium mercurescein
Tetracycline dermal ointment
Tetracycline eye ointment
Zinc oxide ointment

ACICLOVIR eye ointment


(Zovirax)

Prescription under medical supervision

Therapeutic action

Antiviral active against herpes virus

Indications

Treatment of herpes keratitis


Prevention of herpes keratitis in neonate born to a mother suffering from genital herpes at
the moment of childbirth

Presentation

3% ointment, tube

Dosage and duration

Treatment of herpes keratitis


Child and adult: 5 applications/day into the conjunctival sac of both eyes for 14 days or for
3 days after lesions have healed

Prevention of herpes keratitis in neonate


Immediately after birth: wash the eyes with sterile sodium chloride 0,9% then apply a
single dose of aciclovir into the conjunctival sac of both eyes

Contra-indications, adverse effects, precautions

In neonates, wait 12 hours after application of aciclovir 3% then apply tetracycline eye ointment 1% to prevent gonococcal neonatal conjunctivitis.

Remarks

Storage: below 25C


Use within 30 days after first opening.

261

ALCOHOL-BASED solution or gel


(Manugel, Manurub, Sterillium...)

Therapeutic action
Antiseptic

Indications

Antiseptic hand rub, before and after procedures, whether gloves are used or not

Presentation
Use

Ready to use alcohol-based hand rub solution or gel


Alcohol-based hand rubs can only be used if hands are not visibly dirty or soiled with
organic matter. There must be no residual powder on hands (use powder-free gloves) and
hands must be dry.
Apply 3 ml of solution or gel in a cupped hand and spread to cover the entire surface of
hands. Rub hands for 20-30 seconds, palm to palm, palm over dorsum, between fingers
(fingers interlaced), around the thumbs and nails, until hands are completely dry. Do not
dilute the product. Do not rinse off or dry hands.
As long as hands are not visibly soiled, the product may be reapplied as many times as
necessary without handwashing before or after applying the product.

Contra-indications, adverse effects, precautions

Do not use if:


hands are visibly dirty or soiled with organic matter (wash hands),
there is residual powder on hands (wash hands),
hands are wet (water dilutes alcohol and impedes drying).
Do not use after direct contact with a patient with a parasitic skin infection (scabies, lice):
wash hands.
Do not use simultaneously with soap or another antiseptic (antagonism, inactivation, etc.).
Do not use for disinfection of material, patient's skin or mucous membranes.
May cause: stinging sensation on broken skin.
In case of eye contact flush immediately with plenty of water.

Remarks

Dose required and duration of handrubbing may vary depending on the product used.
Read the manufacturer's instructions carefully.
To avoid difficulty in putting on gloves, rub hands until the product is completely dry.
Use of alcohol-based hand rubs may result in a sticky residue on hands after several
applications. In this event, wash hands.
Some alcohol-based hand rubs can be used for surgical hand antisepsis, however the
technique is not the same as for antiseptic hand rub.
Storage: below 25C
Close bottles tightly to avoid evaporation. Keep away from sources of ignition (flame, spark,
incandescent material).

262

ARTESUNATE rectal
Prescription under medical supervision
Therapeutic action
Antimalarial

Indications

Initial (pre-referral) treatment of severe falciparum malaria, before transferring the patient
to a facility where parenteral antimalarial treatment can be administered
Initial treatment of uncomplicated falciparum malaria, when persistent vomiting precludes
oral therapy

Presentation and route of administration


50 mg and 200 mg rectal capsules

Dosage and duration

Severe falciparum malaria


Child and adult: 10 to 20 mg/kg as a single dose before transferring the patient

Uncomplicated falciparum malaria


Child and adult: 10 to 20 mg/kg once daily. As soon as patient can take oral treatment,
administer a 3-day course of an artemisinin-based combination.
Weight

3 to 5 kg

6 to 10 kg

11 to 20 kg

21 to 40 kg
41 to 60 kg
61 to 80 kg

50 mg rectal capsule

200 mg rectal capsule

1
2

2
3
4

Contra-indications, adverse effects, precautions

May cause: gastrointestinal disturbances, headache and dizziness.


Pregnancy: no contra-indication during the 2nd and 3rd trimester. Safety of artesunate during the
first trimester has not been definitely established. However, given the risks associated with malaria,
it may be used during the first trimester if it is the only effective treatment available.
Breast-feeding: no contra-indication

Remarks

Buttocks should be held together for at least 1 minute to ensure retention. If capsules are
expelled from the rectum within 30 min of insertion, re-administer the treatment.
Up to 2 or 3 capsules can be administered simultaneously. When the dose to be administered
is 4 capsules, insert 3 capsules then wait 10 minutes before administering the fourth.
The treatment of choice of severe falciparum malaria is based on IV artesunate or IM
artemether or IV quinine. When it is absolutely impossible to transfer a patient to a facility
where parenteral antimalarial treatment can be administered, artesunate rectal capsules
should be administered once daily until the patient is able to take a 3-day course of an
artemisinin-based combination.
Storage: below 25C
263

BENZOIC acid + SALICYLIC acid ointment


= Whitfields ointment

Therapeutic action

Fungistatic and keratolytic agent

Indications

Dermatophyte infection of the scalp (tinea capitis), in combination with a systemic antifungal
Dermatophyte infection of the glabrous skin and skin folds:
alone, if lesions are localised, non-extensive
in combination with a systemic antifungal, if the lesions are extensive

Presentation

Benzoic acid 6% + salicylic acid 3% ointment, tube or jar

Dosage

Child and adult: 2 applications/day, sparingly, to clean and dry skin

Duration

3 to 6 weeks, depending on clinical response

Contra-indications, adverse effects, precautions

Do not apply to exudative lesions, mucous membranes or eyes.


May cause: skin irritation, local benign inflammation.
In case of secondary bacterial infection, start appropriate local or systemic treatment before
applying Whitfields ointment.
In case of contact with eyes or mucous membranes, flush immediately with plenty of water.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Remarks

Whitfields ointment is not included in the WHO list of essential medicines.


Storage: below 25C
Once the ointment has been exposed to a high temperature, the active ingredients are no longer
evenly distributed: the ointment must be homogenized before using.

264

BENZYL BENZOATE
Therapeutic action
Scabicide

Indications

Scabies

Presentation

25% lotion

Preparation and use

Shake the bottle before application or dilution.


Dilute the lotion, as required, according to age. Use drinking or boiled water.

Preparation

Contact time

Child < 2 years

1 part of 25% lotion


+
3 parts of water

12 hours (6 hours
in children < 6 months)

Child 2-12 years

1 part of 25% lotion


+
1 part of water
24 hours

Child > 12 years


and adult

Undiluted 25% solution


24 hours

Apply the lotion to the whole body, including scalp, postauricular areas, palms and soles.
Pay particular attention to skin creases and interdigital web spaces. Do not apply to the face
and mucous membranes.
In children under 2 years: apply only once; wrap hands to avoid accidental ingestion; rinse
off when the recommended contact time has elapsed.
In children 2 years and adults: a second application (e.g. after 24 hours, with a rinse
between the two applications; or two successive applications, 10 minutes apart, when the
first application has dried, with a rinse after 24 hours) reduces the risk of treatment failure.

Contra-indications, adverse effects, precautions

Do not apply to broken or infected skin. In the event of secondary bacterial infection,
administer an appropriate local (antiseptic) and/or systemic (antibiotic) treatment 24 to
48 hours before applying benzyl benzoate.
May cause: burning sensation; contact dermatitis in case of repeated applications; seizures
in the event of marked transcutaneous absorption (broken skin, children < 2 years).
Avoid contact with eyes. In case of eye contact, flush immediately with plenty of water.
DO NOT SWAllOW (risk of seizures). In case of ingestion: do not induce vomiting, do not
perform gastric lavage; administer activated charcoal.
Pregnancy: no contra-indication; do not leave on skin longer than 12 hours; do not repeat application.
Breast-feeding: no contra-indication; do not apply to breasts.

Remarks

Close contacts should be treated at the same time regardless of whether they have
symptoms or not. Decontaminate clothes and bed linen of patients and close contacts
simultaneously.
Itching may persist for 1 to 3 weeks despite successful treatment. Do not re-treat during this
period. The treatment may be repeated if specific scabies lesions (scabious burrows) are still
present after 3 weeks.
5% permethrin cream or lotion is preferred when available, especially in children less than
2 years and pregnant or lactating women.
Storage: below 25C
265

CALAMINE lotion

Action thrapeutique

Antipruritic drug

Indications

Symptomatic treatment of pruritus

Presentation

Calamine 8% or 15% lotion, bottle

Dosage

Apply a thin layer 3 to 4 times/day

Duration

According to clinical response

Contra-indications, adverse effects, precautions

Clean the skin before applying the lotion.


Do not apply to exudative and/or superinfected lesions, mucous membranes or eyes.
In case of contact with eyes or mucous membranes, flush immediately with plenty of water.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication, do not apply on breasts.

Remarks

Shake the lotion well before using.


Storage: below 25C

266

CHLORHEXIDINE
(Hibitane)

Therapeutic action
Antiseptic

Indications

Antisepsis of minor and superficial wounds and burns

Presentation

5% concentrated solution of chlorhexidine gluconate to be diluted before use


Check that the solution may be diluted with ordinary, non-distilled water (in this event the
formulation should contain a surfactant to prevent the precipitation of chlorhexidine).

Preparation

Use as a 0.05% aqueous solution:


For one litre: 10 ml of 5% concentrated solution + 990 ml of clear water, boiled a few
minutes and cooled

Contra-indications, adverse effects, precautions

Do not use undiluted solution.


Do not bring into contact with body cavities, eyes (risk of corneal damage), brain and
meninges, middle ear (risk of deafness if ear drum is perforated).
Avoid applications to mucous membranes, especially to genital mucous membranes.
Do not use with soap or other antiseptics (incompatibility).

Remarks

Also comes in 20% chlorhexidine gluconate concentrated solutions. These solutions usually
do not contain a surfactant and must be diluted with distilled water.
Storage:
Concentrated solution: below 25C
Diluted solution: maximum one week

267

CHLORINE-RELEASING COMPOUNDS
(NaDCC, HTH, bleach, chlorinated lime)
Therapeutic action
Disinfectants

Indications

Disinfection of medical devices, instruments, linen, floors and surfaces

Presentation

The potency of chlorine disinfectants is expressed in terms of available chlorine in either:


percentage (%)
g/litre or mg/litre
parts per million (ppm)
chlorometric degree (1chl. = approximately 0.3% available chorine)
1% = 10 g/litre = 10 000 ppm
1 mg/litre = 1 ppm = 0.0001%

The most widely used chlorine disinfectants are:

Sodium dichloroisocyanurate (NaDCC), 1,67 g tab ..................1 g available chlorine/tab

Calcium hypochlorite (HTH), granules .......................................65-70% available chlorine

Sodium hypochlorite solutions (liquid bleach):


- concentrated bleach (extrait de javel) ............................36chl. = 9.6% available chlorine
- bleach (eau de Javel)............................9chl or 12chl. = 2.6% or 3.6% available chlorine
Chlorinated lime, powder ..............................................................25-35% available chlorine

Preparation and use

The concentration required depends on the amount of organic material present (how
clean/unclean the surface is).
The available chlorine content must always be checked on the product packaging in order
to adjust the dilution if necessary.
Prepare solutions with cold water in non-metallic containers.
A deposit in HTH solutions and chlorinated lime solutions is normal (use only the supernatant).
Examples

Concentration
required expressed
in available chlorine
NaDCC
(1 g available
chlorine/tablet)

Calcium
hypochlorite (70%
available chlorine)
Bleach
(2.6% available
chlorine)

Clean medical
devices, equipment,
surfaces and linen
(after cleaning)

Surfaces, beds,
utensils
in case of cholera
(after cleaning)

Surfaces, equipment
contaminated
with blood and other
body fluids spills
(before cleaning)

Corpses, excreta,
boots
in case of cholera

0.5%
= 5000 ppm

2%
= 20 000 ppm

1 tab/litre water

2 tab/litre water

5 tab/litre water

20 tab/litre water

For 5 litres:
200 ml
+ 4800 ml water

For 5 litres:
400 ml
+ 4600 ml water

0.1%
= 1000 ppm

0.2%
= 2000 ppm

15 g/10 litres
30 g/10 litres
= 1 level tablespoon = 2 level tablespoons
for 10 litres water
for 10 litres water

7.5 g/litre
= 1/2 tablespoon
for 1 litre water
For 1 litre:
200 ml
+ 800 ml water

For more information, refer to the appendix Antiseptics and disinfectants.


268

300 g/10 litres


= 20 level tablespoons
for 10 litres water
For 5 litres:
4000 ml
+ 1000 ml water

Precautions

Handle concentrated products with caution (avoid jolts and exposure to high temperatures
or flames).
Do not bring dry products, particularly HTH and chlorinated lime, in contact with organic
materials (e.g. corpses): risk of explosion.
Avoid inhaling vapours and dust when opening or handling the containers.

Remarks

Sodium dichloroisocyanurate (NaDCC) is less corrosive than the other products.


Bleach or concentrated bleach, or if not available HTH, may be used to prepare an antiseptic
solution at 0.5% available chlorine (as substitute to Dakin's solution), provided sodium
bicarbonate (one tablespoon per litre) is added to the final solution to neutralise the
alkalinity (e.g. for one litre: 200 ml of bleach 2.6% + 800 ml distilled or filtered water, or if
not available, boiled and cooled water + 1 tablespoon of sodium bicarbonate).
Chloramine T (powder or tablet, 25% available chlorine) is another chlorine-releasing
compound used above all as an antiseptic.
Trichloro-isocyanuric acid (TCCA), in powder or granules (90% available chlorine), is very
similar to NaDCC, but its use is limited due to its poor solubility.
Storage: in airtight, non-metallic containers, protected from light, heat (and humidity for dry
products).

Chlorinated lime, bleach and concentrated bleach are unstable. HTH is more stable. NaDCC is by
far the most stable.

269

CIPROFLOXACIN ear drops


(Ciplox)

Prescription under medical supervision

Therapeutic action

Fluoroquinolone antibacterial

Indications

Chronic suppurative otitis media

Presentation

0.3% ear drops

Dosage

Child over 1 year: 2 to 3 drops 2 times daily in the affected ear


Adult: 4 drops 2 times daily in the affected ear
To administer drops, pull back the auricle and maintain the head to one side for a few
minutes.

Duration: 2 to 4 weeks

Contra-indications, adverse effects, precautions

May cause: headache, local skin eruption or pruritus.


Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Remarks

Do not touch let the dropper touch either hands or the ear.
Storage: no special temperature requirements
Once the bottle has been opened, solution keeps for 4 weeks.

270

CLOTRIMAZOLE
(Gyno-canesten)

Therapeutic action
Antifungal

Indications

Vaginal candidiasis

Presentation and route of administration


500 mg vaginal tablet, with applicator
Also comes in 100 mg vaginal tablets.

Dosage and duration

500 mg vaginal tablet


Adult: one vaginal tablet as a single dose, at bedtime
100 mg vaginal tablet
Adult: one vaginal tablet/day for 6 days, at bedtime

Contra-indications, adverse effects, precautions

May cause: local irritation; allergic reactions.


Pregnancy: no contra-indication (do not use the applicator to avoid mechanical trauma)
Breast-feeding: no contra-indication

Remarks

Place the tablet on the applicator. Insert the applicator high into the vagina. Push the plunger
then remove the applicator.
For the 6-day treatment schedule (100 mg tab):
Do not interrupt treatment during menstruation.
Clean the applicator with water after each use.
Storage: below 25C

271

Revised October 2014

DINOPROSTONE
Prescription under medical supervision

Therapeutic action

Cervical ripening agent, oxytocic drug (prostaglandin analogue)

Indications

Induction of labour when the cervix is not favourable, preferably in combination with
mifepristone in the case of intrauterine foetal death

Presentation and route of administration

Vaginal gel containing 1 mg of dinoprostone, in prefilled syringe

Dosage and duration

1 mg intravaginally into the posterior fornix every 6 hours, until labour begins (max.
3 doses within 24 hours)

Contra-indications, adverse effects, precautions

Do not administer in the event of previous caesarean section and grand multiparity if the
foetus is viable (risk of uterine rupture).
Do not administer simultaneously with oxytocin. At least 6 hours must have elapsed since
the last administration of dinoprostone before oxytocin can be given.
May cause: uterine hypertony, gastrointestinal disturbances, modification of the foetal
heart rate, foetal distress.
Regular monitoring of the intensity and frequency of contractions is mandatory after
administration of dinoprostone.
If the foetus is viable, continuous foetal heart monitoring is mandatory for 30 minutes after
administration of each dose of dinoprostone and once contractions are experienced or
detected.
Breast-feeding: non contra-indication

Remarks

Misoprostol is another prostaglandin used in the induction of labour when the cervix is not
favourable. It is less expensive and easier to store than dinoprostone.
Storage: between 2C and 8C

272

ETHYL ALCOHOL = ETHANOL

Therapeutic action

Antiseptic and disinfectant

Indications

Antisepsis of intact skin prior to injections and venopunctures


Disinfection of latex stopper of infusion bottles and drug vials (except vaccines), latex
injection sites of infusion sets

Presentation

Mixtures of alcohol (ethanol) and water in different concentrations (e.g. 95% v/v ethanol),
sometimes containing additives to avoid their ingestion.
Alcoholic strength is expressed:
preferably as a percentage by volume of alcohol (% v/v); e.g. 1000 ml of 95% v/v alcohol
contains 950 ml of absolute alcohol.
sometimes as a percentage by weight of alcohol (% w/w). The % w/w is not equal to the
% v/v because the mixture of water and alcohol produces a reduction in volume.
sometimes in degrees () but this should be discouraged as it is a source of error. There
are at least 3 different definitions of degrees: the old UK definition ( British proof), the
American ( proof) and the one used in French speaking countries (1 = 1% v/v). For
example: 40% v/v = 70 proof (British system) = 80 proof (American system) = 40 in
French speaking countries.

Preparation

Use 70% v/v ethanol, which is more effective than higher concentrations.
To obtain 1 litre of 70% v/v ethanol:
take 785 ml of 90% v/v ethanol, or 730 ml of 95% v/v ethanol, or 707 ml of 99% v/v
ethanol,
add distilled or filtered water to make up a volume of 1 litre,
leave to cool and top up with water again to bring the volume back to 1 litre (mixing
water and ethanol together produces a reaction whereby volume is reduced).

Precautions

Do not apply to mucous membranes, wounds or burns: it is painful, irritating and slows
the healing process.
Do not apply on neonatal skin.

Remarks

Ethanol can be used for disinfection of non-critical medical items (items that are in contact
with intact skin only) that are not soiled by blood or other body fluids.
Critical medical items (surgical instruments, etc.) cannot, under any circumstances, be
sterilized by alcohol flaming, immersion in ethanol or wiping with ethanol.
Storage: below 25C
Close bottles tightly to avoid evaporation. Keep away from sources of ignition (flame, spark,
incandescent material).

273

FLUORESCEIN

Therapeutic action

Ophthalmic diagnostic agent

Indications

Detection of corneal or conjunctival epithelial damage

Presentation

0.5% or 2% eye drops in single use vial

Dosage and duration

Instill 1 or 2 drops into the conjunctival sac.


Ask patient to blink a few times to spread the dye around; remove excess fluorescein and
proceed with the examination.

Contra-indications, adverse effects, precautions

May cause: local allergic reaction (rare).


Wait 15 minutes before administering any other kind of eye drops.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Remarks

To facilitate the examination, use an ophthalmoscope with a blue filter (increases


fluorescence).
Under normal light, large lesions are visible but small lesions cannot be detected.
Storage: below 25C
Vials are designed for single use only; they must be discarded after use.

274

Alcoholic solutions of IODINE


(iodized alcohol, iodine tincture)

The use of alcoholic solutions of iodine is not


recommended. They are very irritating, expensive
and difficult to store; the alcohol evaporates
(solutions become even more irritating as they
age).
Polyvidone iodine is much less irritating and
easier to store.

Therapeutic action
Antiseptic
Antifungal

Indications

Antisepsis of intact skin (skin cleansing prior to injections, puncture, surgery)


Treatment of fungal infections of the skin

Presentation

Iodized alcohol (1 or 3% iodine in 50 to 90% ethanol v/v)


Iodine tincture (5% iodine in 80 or 90% ethanol v/v + 3% potassium iodine) is a very
concentrated preparation that should no longer be used.

Contra-indications, adverse effects, precautions

Do not apply to mucous membranes, wounds or burns: the alcohol is painful, irritating and
slows the healing process.
May cause: skin reactions, allergic reactions.
Incompatible with mercury compounds (merbromine, etc).

Remarks

Storage: maximum of a few weeks

275

MALATHION
(Prioderm)

Therapeutic action

Pediculicide (organophosphorus insecticide)

Indications

Head pediculosis (lice)

Presentation
Use

0.5% lotion
Apply lotion to hair and scalp; pay particular attention to the areas behind the ears and
around the nape of the neck.
leave on hair for:
8 hours in children from 6 months to 2 years
12 hours in children over 2 years and adults
Rinse with plenty of water.
It is recommended to repeat the application after 10 days.

Contra-indications, adverse effects, precautions

Use with caution and under medical supervision in children under 2 years.
May cause: scalp irritation.
Avoid contact with eyes. In the event of product entering the eye, rinse with plenty of
water.
NEVER SWAllOW. The first signs of poisoning after accidental ingestion are gastrointestinal
disturbances (vomiting, diarrhoea). Dyspnoea, seizures or coma are signs of severe intoxication.
As soon as the first signs appear, administer injectable atropine as an antidote.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Remarks

Examine everyone in contact with a patient and treat only those infected. Preventive
treatment of non-infected persons is ineffective and increases the risk of resistance.
Malathion is flammable. Keep medication away from heat sources.
Malathion is not included in the WHO list of essential medicines.
Storage: below 25C

276

MERBROMIN = SODIUM MERCURESCEIN


(Mercurochrome)

The use of this drug is not recommended:


it is toxic and allergenic,
it is a weak antiseptic,
it is inactivated by organic matter,
it is expensive.

Therapeutic action
Antiseptic

Indications

Antisepsis of minor and superficial wounds

Presentation

Powder to be dissolved
1 or 2% aqueous solutions ready for use
2% alcoholic solution ready for use

Contra-indications, adverse effects, precautions

Do not use with iodine compounds (iodised alcohol, polyvidone iodine): risk of necrosis.
May cause:
renal, neurologic and gastrointestinal toxicity due to the resorption of mercury through
skin,
frequent allergic reactions, often associated with a hypersensitivity to all mercurial
compounds (other mercurial antiseptics, dental amalgams, preservatives used in
cosmetics).
Colours the skin: may mask an inflammatory reaction.

Remarks

Aqueous solutions have a very weak antiseptic activity. Alcoholic solutions are more
effective. However merbromin carries serious adverse effects and the use of all solutions
must therefore be abandoned.
Other mercurial compounds: phenylmercuric borate, mercurobutol (Mercryl), thiomersal
(Thimerosal) have the same adverse effects and must also be abandoned.
Merbromin is not included in the WHO list of essential medicines.
Storage: no special temperature requirements

277

METHYLROSANILINIUM CHLORIDE
= GENTIAN VIOLET = GV = CRYSTAL VIOLET
Carcinogenic effects have been demonstrated in animals.
As a precaution, this product should not be used in
humans if an alternative is available.

Therapeutic action

Antifungal, weak antiseptic, drying agent

Indications

Oropharyngeal candidiasis, mammary candidiasis in nursing mothers


Certain wet skin lesions (impetigo, dermatophytosis oozing lesions)

Presentation

Powder to be dissolved

Preparation

Use

Dissolve 2.5 g of powder (= one half-teaspoon) in 1 litre of clear water (boiled a few minutes
and cooled) to obtain a 0.25% solution.
Shake well and leave to settle. Pour carefully into another bottle to eliminate any possible
sediment.
Before preparation, carefully wash both the bottle for dilution and the storage bottle with
hot water and leave to dry.
2 applications/day for a few days

Contra-indications, adverse effects, precautions

Do not apply to wounds or ulcerations.


Do not apply to the face or genital mucous membranes.
May cause:
irritation, ulcerations, allergic reactions,
persistent staining of the skin.
The solution should not be swallowed.
The use of cooking oil or vaseline around lips before swabbing can limit the risk of skin
coloration.
Stop treatment in the event of allergic reactions or if new ulcerations develop.
In the event of product entering the eye, rinse with plenty of water.
Avoid contact with clothes (causes permanent staining of fabrics).

Remarks

Gentian violet is no longer included in the WHO list of essential medicines.


Storage:
Powder to be dissolved: unlimited
Diluted solution: maximum 1 week

278

MICONAZOLE

Therapeutic action
Antifungal

Indications

Cutaneous candidiasis (groin, abdominal folds, intergluteal fold, sub-mammary folds,


interdigital spaces of the toes or fingers)
Candidal balanitis
Mild dermatophyte infection of the glabrous skin and skin folds

Presentation

2% cream, tube

Dosage

Child and adult: 2 applications/day, sparingly, to clean and dry skin

Duration

Cutaneous candidiasis: 2 to 4 weeks


Candidal balanitis: one week
Dermatophyte infection: 2 to 3 weeks

Contra-indications, adverse effects, precautions

May cause: local irritation; allergic reactions.


In the event of genital candidiasis, inform patients that the fat content in the cream
damages the latex in condoms and diaphragms: protection no longer guaranteed due to
increased porosity and risk of rupture.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication. In the event of mammary candidiasis, clean the breast before
nursing and apply cream after nursing.

Remarks

For the treatment of vulvovaginal candidiasis, miconazole cream may complement, but
does not replace, treatment with clotrimazole or nystatin vaginal tablets.
Storage: below 25C

279

MUPIROCIN
Prescription under medical supervision
Mupirocin should not be used in patients with
extended impetigo (more than 5 lesions or more than
one skin area involved), bullous impetigo, ecthyma,
impetigo with abscess, and in immunodeficient
patients: in such cases, oral antibiotic therapy is
required.

Therapeutic action
Antibacterial

Indications

localized non bullous impetigo (less than 5 lesions in a single area)

Presentation

2% ointment, tube

Dosage and duration

Child and adult: 3 applications/day for 7 days, to clean and dry skin
The patient should be reassessed after 3 days. If there is no response, switch to oral
antibiotic therapy.

Contra-indications, adverse effects, precautions

May cause: pruritus and burning sensation; allergic reactions.


If applying to the face, avoid contact with eyes.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication. Do not apply to the breasts.

Remarks

Do not mix with other ointments (effect of mupirocin decreased).


Avoid touching the lesions; keep them covered with gauze if possible.
Storage: below 25C

280

NYSTATIN
(Mycostatin)

Therapeutic action
Antifungal

Indications

Vaginal candidiasis

Presentation and route of administration


100 000 IU vaginal tablet

Dosage and duration

Adult: one tablet of 100 000 IU/day at bedtime for 14 days

Contra-indications, adverse effects, precautions

May cause (rarely): local irritation, allergic reactions.


Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Remarks

Tablets must be moistened and inserted high into the vagina.


Do not interrupt treatment during menstruation.
Prefer clotrimazole 500 mg vaginal tablet as a single dose for this indication.
Storage: below 25C
Once a tablet is removed from the packaging, it must be used immediately.

281

OXYBUPROCAINE eye drops


(Novesin)

Prescription under medical supervision

Therapeutic action

local anaesthetic

Indications

Short-term anaesthesia of conjunctiva and cornea

Presentation

0.4% eye drops in single use vial

Dosage and duration

Removal of foreign bodies: up to 3 drops into the conjunctival sac, administered one to two
minutes apart
Measurement of intraocular pressure: 1 drop into the conjunctival sac

Contra-indications, adverse effects, precautions

Do not use repeatedly (risk of severe and permanent corneal damage).


May cause: stinging on instillation.
Wait 15 minutes before administering any other kind of eye drops.
Pregnancy: no contra-indication
Breastfeeding: no contra-indication

Remarks

Anaesthesia is produced within one minute and lasts 10 to 20 minutes.


Anaesthetic eye drops (oxybuprocaine, tetracaine, etc.) are intended for specific therapeutic
or diagnostic procedures. They must not be given to the patient for home use. In the event
of intense ocular pain, prescribe an appropriate oral analgesic.
Storage: below 25C
Vials are designed for single use only; they must be discarded after use.

282

PERMETHRIN 1%

Therapeutic action

Pediculicide (pyrethroid insecticide)

Indications

Head pediculosis (lice)

Presentation
Use

1% lotion
Apply lotion to hair and scalp; pay particular attention to the areas behind the ears and
around the nape of the neck.
leave on hair for 10 minutes.
Rinse with plenty of water.
It is recommended to repeat the application after 10 days.

Contra-indications, adverse effects, precautions

Use with caution and under medical supervision in children under 6 months.
May cause: scalp irritation.
Avoid contact with eyes. In case of eye contact, flush immediately with plenty of water.
NEVER SWAllOW. In case of accidental swallowing, the treatment is symptomatic.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication

Remarks

Examine everyone in contact with a patient and treat only those infected. Preventive treatment
of non-infected persons is ineffective and increases the risk of resistance.
For better results, use the lotion rather than the shampoo.
Permethrin 5% cream is used for the treatment of scabies in children over 2 months and
adults.
Storage: below 25C

283

PERMETHRIN 5%

Therapeutic action

Scabicide (pyrethroid insecticide)

Indications

Scabies

Presentation
Use

5% cream or lotion
Apply the cream or lotion to the whole body, including scalp, postauricular areas, palms
and soles. Pay particular attention to skin creases and interdigital web spaces. Do not apply
to the face and mucous membranes.
In children under 2 years: wrap hands to avoid accidental ingestion.
leave on skin for 8 to 12 hours then rinse off.
A single application may be sufficient. A second application 7 days later reduces the risk of
treatment failure.

Contra-indications, adverse effects, precautions

Do not use in children under 2 months (safety not established).


Do not apply to broken or infected skin. In the event of secondary bacterial infection,
administer an appropriate local (antiseptic) and/or systemic (antibiotic) treatment 24 to
48 hours before applying permethrin.
May cause (rarely): skin irritation.
Avoid contact with eyes. In case of eye contact flush immediately with plenty of water.
NEVER SWAllOW. In case of accidental ingestion, the treatment is symptomatic.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication; do not apply to breasts.

Remarks

Close contacts should be treated at the same time regardless of whether there have
symptoms or not. Decontaminate clothes and bed linen of patients and close contacts
simultaneously.
Itching may persist for 1 to 3 weeks despite successful treatment. Do not re-treat during this
period. The treatment may be repeated if specific scabies lesions (scabious burrows) are still
present after 3 weeks.
5% permethrin used for the treatment of scabies is not to be confused with 1% permethrin
used for the treatment of head and pubic lice.
Storage: below 25C

284

PILOCARPINE eye drops


Prescription under medical supervision
Therapeutic action

Cholinergic anti-glaucoma agent, miotic

Indications

Chronic open-angle glaucoma

Presentation

2% eye drops
Also comes in 4% eye drops.

Dosage

Adult: 1 drop into the conjunctival sac 4 times daily

Duration: life-long treatment

Contra-indications, adverse effects, precautions

Do not administer to children.


Do not administer to patients with iridocyclitis and some forms of secondary glaucoma.
Do not administer to patients with history of retinal detachment (trauma or family history)
nor to myopic patients, except if it is possible to examine the peripheral retina (fundus
examination) prior to the initiation of therapy and routinely thereafter.
May cause:
transient blurred vision, visual field modification, difficulty with dark adaptation
(inform patients, especially drivers);
retinal detachment in patients with myopia;
ocular irritation, headache (decreasing after 2 to 4 weeks); rarely, allergic reactions.
In case of treatment with another eye drop, wait 5 minutes before instilling the second eye
drop treatment.
Patients should have regular monitoring of intraocular pressure during therapy.
Pregnancy: no contra-indication
Breastfeeding: no contra-indication

Remarks

Do not touch the dropper with the hands.


Storage: no special temperature requirements
Once the bottle has been opened, solution keeps for 2 weeks.

285

PODOPHYLLOTOXIN 0.5%
(Condyline, Condylox, Wartec)

Prescription under medical supervision

Therapeutic action

Antiviral, antimitotic, cytolytic agent active against human papillomaviruses (HPVs)

Indications

External genital warts, perianal warts and vaginal warts

Presentation

0.5% solution or gel, with applicator tips

Dosage

Apply podophyllotoxin to warts twice daily.


For vaginal warts, allow to dry before removing the speculum.

Duration

3 consecutive days per week, for a maximum of 4 weeks

Contra-indications, adverse effects, precautions

Do not use to treat genital warts in children.


Do not apply to warts > 3 cm.
Do not apply to cervical, urethral, anorectal or oral warts.
Do not apply to healthy skin.
May cause local reactions: erythema, ulceration, pain in area where applied.
Use a new applicator tip for each application.
Avoid contact with eyes. In case of eye contact flush immediately with plenty of water.
Pregnancy: CONTRA-INDICATED
Breast-feeding: CONTRA-INDICATED

Remarks

When treatment is contra-indicated or has failed after 4 weeks, change treatment method
(cryosurgery, electrosurgery, surgical removal).
Storage: below 25C

286

PODOPHYLLUM resin
Prescription under medical supervision
Therapeutic action

Antiviral, antimitotic, cytolytic agent active against human papillomaviruses (HPVs)

Indications

External genital warts, perianal warts and vaginal warts

Presentation
Use

Podophyllum resin in alcohol or compound benzoin, 10%, 15% and 25% solution.
Always apply a protective layer of vaseline or zinc ointment on the surrounding skin prior
to treatment.
Apply podophyllum resin to warts:
For external warts, leave on the warts for 1 to 4 hours then wash with soap and water.
For vaginal warts, allow to dry before removing the speculum.

Duration

Apply once weekly if necessary, for a maximum of 4 weeks.

Contra-indications, adverse effects, precautions

Do not use to treat genital warts in children.


Do not apply to healthy skin or mucous membranes, or to warts > 3 cm, or to cervical,
urethral, anorectal or oral warts.
May cause:
local reactions: erythema, ulceration, pain in area where applied,
systemic adverse effects: gastrointestinal disturbances, haematological and neurological
disorders (possibly severe) in the event of prolonged or excessive application, or when
applied to bleeding lesions.
Avoid contact with eyes. In case of eye contact flush immediately with plenty of water.
Pregnancy: CONTRA-INDICATED
Breast-feeding: CONTRA-INDICATED

Remarks

Use by preference 0.5% podophyllotoxin solution: it is as effective as podophyllum resin,


but less irritant and toxic. Another advantage is that the patient may apply the solution to
the warts himself; whereas the resin must always be applied by medical staff.
When treatment is contra-indicated or has failed after 4 weeks, change treatment method
(cryosurgery, electrosurgery, surgical removal).
Storage: below 25C

287

POLYVIDONE IODINE = POVIDONE IODINE = PVI


aqueous solution (Betadine dermal solution)

Therapeutic action

Antiseptic and disinfectant

Indications

Antisepsis of intact or broken skin and mucous membranes


Disinfection of latex stopper of infusion bottles and drug vials (except vaccines), latex
injection sites of infusion sets

Presentation
Use

10% aqueous solution


Antisepsis of intact skin (injections, punctures)
Apply 10% solution to the puncture/injection site and allow to dry before inserting the
needle. The skin should be cleaned beforehand if soiled or if the procedure is invasive
(lumbar puncture, epidural/spinal anaesthesia, etc.).
Preoperative skin antisepsis
Apply 10% solution twice. Allow to dry between each application (do not dab to accelerate
drying). Incise once the 2nd application has dried. The surgical site should be cleaned
beforehand with PVI scrub solution.

Wound antisepsis
Apply 10% solution to small superficial wounds.
For large wounds and burns, wound irrigation, etc., dilute PVI (1/4 of 10% PVI and 3/4 of
0.9% NaCl or sterile water) then rinse with 0.9% NaCl or sterile water.

Contra-indications, adverse effects, precautions

Do not use with other antiseptics such as chlorhexidine-cetrimide (incompatibility) or


mercury compounds (risk of necrosis).
Do not use in preterm neonates and neonates < 1.5 kg.
Due to the risk of transcutaneous resorption of iodine, do not use repeatedly nor on large
areas, especially in pregnant and lactating women and infants < 1 month.
May cause: local skin reactions; exceptionally, allergic reactions.

Remarks

The antiseptic effect of PVI begins after 30 seconds of contact. However, a minimum contact
time of 1 minute is recommended to eliminate bacteria.
Storage: below 25C
Once the bottle has been opened, solution keeps 30 days.

288

POLYVIDONE IODINE = POVIDONE IODINE = PVI


scrub solution (Videne scrub, Betadine scrub)
Therapeutic action
Antiseptic

Indications

Antiseptic hand wash and surgical hand antisepsis


Preoperative skin preparation (patient preoperative showering, antiseptic cleansing of the
surgical site)
Cleansing of contaminated wounds

Presentation
Use

7.5% scrub solution. Also comes in 4% scrub solution.

Antiseptic hand wash


Wet hands; pour 5 ml of solution; rub hands for 1 min; rinse thoroughly; dry with a clean
towel.
Surgical hand antisepsis
There are different protocols, for information:
Wet hands and forearms; spread 5 ml of solution on hands and forearms and rub for 1 or
2 min (i.e. 30 seconds or 1 min for each side); brush the nails of each hand for 30 seconds;
rinse.
Spread again 5 ml of solution on hands and forearms and rub for 2 min; rinse thoroughly;
dry with a sterile towel.
Patient preoperative showering
Wet the whole body including hair; apply the solution and rub until the foam is white, start
at the head and move down, finishing with the feet. Pay special attention to hair, armpit,
hands, perineum, genitals and toes. leave in contact a few minutes and rinse. Dry with a
clean towel; put on clean clothes.
Antiseptic cleansing of surgical site
Rub for 1 min the surgical site, using sterile gauze soaked with sterile water and solution;
rinse with sterile water; dry with sterile gauze.
Cleansing of contaminated wounds
Prepare a diluted solution:
With 7.5% solution: 1 part of solution + 4 parts of sterile 0.9% NaCl or water
With 4% solution: 1 part of solution + 2 parts of sterile 0.9% NaCl or water
Clean the wound; rinse thoroughly.

Contra-indications, adverse effects, precautions

Do not use with others antiseptics such as chlorhexidine-cetrimide (incompatibility) or


mercury compounds (risk of necrosis). Given the possible interactions between different
groups of antiseptics, PVI scrub solution must only be used with products of the same
group (i.e. PVI aqueous or alcoholic solutions).
Do not use in preterm neonates and neonates < 1.5 kg (use ordinary soap).
May cause: local skin reactions (contact dermatitis); exceptionally: allergic reactions.
Pregnancy and breast-feeding: no contra-indication for brief application; no prolonged use.

Remarks

For preoperative skin preparation, cleansing of the surgical site is followed by the application
of 10% PVI solution.
Storage: below 25C

289

POTASSIUM PERMANGANATE

The use of this drug is not recommended because of


frequent mistakes in dilution when using crystals or
solutions, and the risk of ingestion when using tablets.

Therapeutic action

Weak antiseptic

Indications

Cleansing of wounds, ulcers, abscesses


Treatment of oozing eczema

Presentation

0.25 g, 0.40 g and 0.50 g tablets to be dissolved before use


Crystals to be dissolved before use
0.1% concentrated aqueous solution to be diluted before use

Preparation and use

Prepare a 0.01% solution with clear water, boiled a few minutes and cooled. The concentration must be precise:
if it is too low: ineffective
if it is too high: caustic
Tablets: one 0.25 g tablet in 2.5 litres of water or one 0.40 g tablet in 4 litres of water or one
0.50 g tablet in 5 litres of water
0.1% concentrated aqueous solution: dilution 1:10
Crystals: 100 mg in 1 litre of water. Use scales to weigh the crystals in order to obtain the
correct concentration.
Use as wet dressings and baths.

Contra-indications, adverse effects, precautions

Do not insert into vagina (risk of haemorrhage, perforation, peritonitis).


May cause: irritation and dryness of skin in the event of repeated applications.
Do not store permanganate tablets near oral tablets.
NEVER SWAllOW. Ingestion may cause: nausea, vomiting, gastrointestinal damages (oedema,
burns, haemorrhage); cardiovascular depression, etc.
Handle crystals, tablets and concentrated solutions with caution: risk of burns (wear
gloves); risk of explosion when brought into contact with readily oxidisable substances.
In the event of product entering the eye, rinse with plenty of water for 15 minutes.

Remarks

Storage:
Dry product: in a cool place, in airtight containers

0.01% solution diluted for use: do not store, prepare just before use.

290

SILVER SULFADIAZINE
(Dermazin, Flamazine, Sicazine)

Therapeutic action

Antibacterial (group of sulfonamides)

Indications

Prophylaxis and treatment of infections of burns (except superficial, first-degree burns)


Treatment of infections of leg ulcers and bed sores

Presentation
Use

1% sterile cream, tube or jar


Clean the wound then apply a 3 to 5 mm layer of silver sulfadiazine cream to the wound
once daily and cover with sterile compresses.

Duration

Until satisfactory healing has occurred.


For burns that require skin grafting: until skin graft is performed.

Contra-indications, adverse effects, precautions

Do not use:
in patients with hypersensitivity to sulfonamides.
in infants less than one month.
Do not apply other topical treatments to wounds where silver sulfadiazine is applied.
May cause:
skin reactions,
when applied to a large burned area: systemic absorption with risk of adverse effects
related to sulfonamides (haematologic disorders, gastrointestinal disturbances, etc.).
Pregnancy: avoid if possible during the last month of pregnancy
Breast-feeding: no contra-indication

Remarks

Storage: between 8C and 25C


Close the tube or the jar properly after opening to avoid exposure to light.

291

SODIUM DICHLOROISOCYANURATE = NaDCC

Therapeutic action

Disinfectant (chlorine-releasing compound)

Indications

Disinfection of medical devices, instruments, linen, floors and surfaces

Presentation

1.67 g NaDCC effervescent tablet, releasing 1 g available chlorine when dissolved in water.
Also comes in different strengths and in granules and powder.

Preparation and use

Pre-disinfection of soiled instruments


0.1% available chlorine solution (1000 ppm): 1 tablet of 1 g available chlorine per litre
Immediately after use, soak instruments for 15 minutes, then clean instruments.
Disinfection of clean instruments
0.1% available chlorine solution (1000 ppm): 1 tablet of 1 g available chlorine per litre
Soak previously cleaned instruments for 20 minutes, rinse thoroughly and dry.
Disinfection of linen
0.1% available chlorine solution (1000 ppm): 1 tablet of 1 g available chlorine per litre
Soak for 15 minutes, rinse thoroughly (at least 3 times).

General disinfection (surfaces, floors, sinks, equipment, etc.): see Chlorine-release compounds and
the appendix Antiseptics and disinfectants.

Precautions

Prepare solutions with cold water, in non metallic containers.


NaDCC can corrode metal. The risk is limited for good quality stainless steel instruments
if concentration, contact time (20 minutes maximum) and thorough rinsing recommen dations are respected.
For disinfection of linen: use only for white cotton or linen (risk of discolouration).
Do not expose the product to flames. Do not incinerate.
DO NOT SWAllOW. Do not store NaDCC tablets near oral tablets.
Avoid inhaling vapours and dust when opening or handling the containers.
Do not mix with acid solutions such as urine, etc. (release of toxic chlorine gas) and
detergents.

Remarks

NaDCC may be used for wound antisepsis but only if the formulation is intended for this
purpose: 0.1% available chlorine solution (1000 ppm): 1 tablet of 1 g available chlorine per
litre. For prolonged use, protect the healthy skin around the wound with vaseline.
Caution: some formulations used for disinfecting floors contain additives (detergents,
colouring, etc.) and cannot be used on wounds. Check label or leaflet.
Some formulations can be used for the disinfection of drinking water (Aquatabs, etc.).
Follow manufacturer's instructions.
NaDCC is also called sodium troclosene, sodium dichloro-s-triazinetrione.
Storage: in airtight container, protected from light, heat and humidity, in a well ventilated
room.

292

TETRACYCLINE dermal ointment


Prescription under medical supervision
Therapeutic action
Antibacterial

Indications

No indications.
Regular washing with antiseptic is often enough to treat a skin infection. If this fails, use
oral antibiotics rather than local antibiotics.

Presentation

3% tetracycline ointment, tube or jar

Contra-indications, adverse effects, precautions

May cause: eczema, photosensitivity.


In the event of eye infection, do not apply dermal ointment to the eyes. Use only tetracycline
eye ointment.

Remarks

Storage: below 25C


Do not use after expiry date.

293

TETRACYCLINE eye ointment

Therapeutic action
Antibacterial

Indications

Treatment of bacterial conjunctivitis


Treatment of trachoma (by preference use oral azithromycin for this indication)
Prevention of chlamydial and gonococcal neonatal conjunctivitis

Presentation

1% ointment, tube

Dosage and duration

Wash the eyes with boiled and cooled water before each application. Use sterile sodium
chloride 0.9% for newborns.
Apply tetracycline 1% into the conjunctival sac of both eyes:
Conjunctivitis: 2 applications/day for 7 days
Trachoma: 2 applications/day for 6 weeks
Prevention of neonatal conjunctivitis: one single application immediately after birth

Contra-indications, adverse effects, precautions

Do not use in patients with hypersensitivity to tetracyclines.


May cause allergic reactions; stop treatment in the event of serious reaction.

Remarks

Tetracycline eye ointment replaces silver nitrate 1% eye drops for the prevention of
neonatal conjunctivitis.
For the treatment of trachoma, azithromycin as single dose is as effective as a 6-week course
of tetracycline ointment.
Gonococcal neonatal conjunctivitis must be treated systemically with ceftriaxone IM
(125 mg as a single dose). When systemic treatment cannot be given immediately, apply
tetracycline eye ointment to both eyes every hour until ceftriaxone is available.
Oxytetracycline (Terramycin) and chlortetracycline (Aureomycin) are used in the same
way as tetracycline.
In the event of eye infection, use only eye ointment; dermal ointment must never be
applied to the eyes.
Storage: below 25C
Do not use after expiry date.

294

ZINC OXIDE ointment

Therapeutic action

Skin protector

Indications

Dermatosis of kwashiorkor
Nappy rash
Eczema
First-degree burns
Protection of healthy skin when caustic products such as podophyllum resin or podophyllotoxin are to be applied

Presentation

10% zinc oxide ointment, tube or jar

Dosage

1 to 3 applications/day

Duration

According to clinical response

Contra-indications, adverse effects, precautions

Clean the skin before applying the ointment.


Do not apply to exudative and/or superinfected lesions.
Pregnancy: no contra-indication
Breast-feeding: no contra-indication, do not apply on breasts

Remarks

Storage: below 25C


Once the ointment has been exposed to a high temperature the active ingredients are no longer
evenly distributed: the ointment must be homogenized before using.

295

Part two
1. Organisation and management of a pharmacy

297

3. Prescription, cost, compliance

313

2. Drug quality and storage

4. Use of antibacterials

5. Antiseptics and disinfectants

6. WHO list of essential medicines


7. Main references

8. Alphabetical index

309

317
323
329
367
368

Organisation and management of a pharmacy

Organisation and management of


a pharmacy
Preliminary information
Layout of a pharmacy

Management of a pharmacy

Organisation and rigorous management of the pharmacy are crucial in all health
facilities in order to:
maintain a permanent stock of essential medicines and supplies of quality;
reduce costs;
save time and optimise the work of the staff;
facilitate management and continuous consumption evaluation.
In any case, national pharmaceutical policies and regulations must be taken into
account when implementing pharmaceutical activities.

Preliminary information
Drug designation

All active ingredients have an international non-proprietary name (INN). Drugs are
designated by their INN in all standardised lists. The INN should also be used in
standard therapeutic regimens and management documents, in order to avoid
confusion, since drugs are sold under their INN or a variety of brand names,
depending on the manufacturer (e.g. ampicillin may be sold as Britapen,
Penbritin, Pentrexyl, Totapen).
Generic drugs are copies of drugs whose patents have expired. They can therefore be
made by any pharmaceutical laboratory and are most often sold under their INN or
occasionally under a new brand name.

297

Organisation and management of a pharmacy

Selection of essential medicines

Most countries have a national list of essential medicines. If there is no national list,
refer to the latest WHO list.
The use of such a list presents several advantages:
it simplifies supply and reduces costs: most drugs on the WHO list are available in
generic forms at affordable prices;
it facilitates co-ordination of international aid and obtains approval from
organisations which subsidise projects (United Nations, European Union, etc.).

The list of selected drugs is drawn in accordance with pre-established standardised


therapeutic regimens. This offers two major advantages:
better treatments due to more rational use of a restricted number of essential
drugs;
economic and administrative improvements concerning purchasing, storage,
distribution and control.

Proposing the same drug in many different strengths or forms should be avoided. In
most cases, one form/strength for adults and one paediatric form/strength are
sufficient. This facilitates management and avoids confusion in prescriptions.
At times, local prescription usages should be taken into account, e.g. in Frenchspeaking Africa, 500 mg aspirin tablets are used; in English-speaking Africa, 300 mg
tablets.
Note: medical supplies (dressing, injections, sutures, etc.) should be limited to
essentials and the object of a standardised list.

Drug classification

In the WHO list, drugs are classified according to their therapeutic action. This
classification presents a certain pedagogical advantage but cannot be used as the
basis of a storage arrangement system (e.g. a drug may appear in several
classes).

Mdecins Sans Frontires recommends a storage arrangement system according to


the route of administration and in alphabetical order.
Drugs are divided into 6 classes and listed in alphabetical order within each class:
oral drugs
injectable drugs
infusion fluids
vaccines, immunoglobulins and antisera
drugs for external use and antiseptics
disinfectants
This classification should be used at every level of a management system (order
forms, stock cards, inventory lists, etc.) in order to facilitate all procedures.

Levels of use

More limited lists should be established according to the level of health structures
and competencies of prescribers. Restricted lists and the designation of prescription
298

Organisation and management of a pharmacy

and distribution levels should be adapted to the terminology and context of


each country.

Quantitative evaluation of needs when launching a programme

Once standard therapeutic regimens and lists of drugs and supplies have been
established, it is possible to calculate the respective quantities of each product
needed from the expected number of patients and from a breakdown of
diseases.
Several methods have been suggested (see "Estimating drug requirements", WHO).
Quantities calculated may differ from those corresponding to true needs or demands
(this can be the case when the number of consultations increases or when prescribers
do not respect proposed therapeutic regimens).

In an emergency situation (especially with displaced population), the Emergency


Health Kit, developed in collaboration with the WHO, UNHCR, MSF, etc., is designed
to meet the care needs of a displaced population of 10,000 people for 3 months.
Afterwards, specific local needs should be evaluated in order to establish a suitable
supply.
Routine evaluation of needs allows verification of how well prescription schemes are
respected and prevents possible stock ruptures.

Layout of a pharmacy
Whether constructing a building, converting an existing building, central warehouse
or health facility pharmacy, the objectives are the same only the means differ.

Premises

Functional premises should be designed in order to assure:


the safe keeping of stocks;
correct storage of drugs and supplies;
rational and easy management.

Characteristics of a warehouse

Dimensions of warehouse are determined by storage needs, which depend on:


the number of drugs and supplies to be stocked;
the number and activities of facilities;
distribution and receiving frequency: the lesser the frequency the greater the
volume needed, thus the greater the space needed.
299

Organisation and management of a pharmacy

It is better to have too much space than not enough: a cramped warehouse is difficult
to work, and any increases in stock or activity are also difficult. For 1 m2 of storage
space count 3 m2 of floor space.
Security of stocks requires solid doors, locks, windows and ceilings.

Correct preservation of drugs depends on temperatures and humidity, conditions


that are very often difficult to control in tropical countries.
Correct ventilation is necessary; fans mainly reduce humidity, air-conditioning
reduces heat and humidity.
A ceiling underneath the roof is essential in order to reduce the ambient
temperature; the space between the ceiling and roof must be ventilated.
Windows should be shaded to avoid exposure of drugs to direct sunlight.
Floors should be covered in cement (slightly inclined, if possible, to facilitate
maintenance).

Interior layout of a warehouse

The organisation should be logical and correspond to the circuit "reception, storage,
distribution".
Shelves and pallets

Solid and stable shelves are indispensable. In tropical countries where termites attack
wood, metal structures are preferred. As they can be dismantled, it is easy to adjust
spaces between shelves and alleys to better accommodate goods to be stored.
Space between shelves and walls improves ventilation.

No products or packaging, even large-sized, should be stored on the floor, but on


pallets which permit air circulation and protect against humidity.
Stocking areas

Within a warehouse, or close by, stocking areas should be provided.

Receiving area: for stocking parcels before unpacking and checking freight and
quality control.

Distribution area: for stocking peripheral orders before distribution. Each


destination should have a designated area where parcels may be stocked before
distribution.
Receiving and distribution areas should be near access doors in order to facilitate
handling.
It is also recommended to plan a stocking area for empty boxes, used to prepare
orders for peripheral health facilities.

300

Organisation and management of a pharmacy

Workspace(s)

A workspace should be set up in order to verify deliveries and prepare orders.


Desk

For the person in charge of the pharmacy, a desk near a light source should be set up
for administrative work and for keeping documents.
Examples of pharmacy layout
Schema 1

Schema 2

The arrangement of shelves, tables or other furniture, varies according to the layout of
the premises.
For larger stocks or central pharmacies, use several rooms and apply the same
principles by adapting layouts to needs: administration, cold room, refrigerators, etc.

301

Organisation and management of a pharmacy

Arrangement of drugs and supplies

Storage of drugs not requiring a cold chain

Drugs are arranged according to the classification adopted:


oral drugs
injectable drugs
infusions
drugs for external use and antiseptics
disinfectants

In each category of products (oral, injectable, etc.) are classified alphabetically.

Each product should have a designated place, well identified by a fixed label
indicating the INN, form and strength. By attributing a specific place to each item it
is possible to immediately see the quantity available and to react quickly to avoid
stock shortages.
Provide for sufficient space between and for each product.

Clearly indicate expiry dates on boxes (large marker). Arrange products with the
earliest expiry date at the front of the shelves and those with the latest at the back.
This is essential to avoid drugs expiring during storage.

So that persons not familiar with the INN system can find their way around in case
of emergency or replacement, a list of commercial names and the corresponding INN
can be put up, e.g.:
Bactrim
see cotrimoxazole
Clamoxyl
see amoxicillin
Flagyl
see metronidazole
Valium
see diazepam
Storage of controlled substances

Narcotics and other controlled substances should be placed under lock and key.
Storage of products requiring a cold chain

Products needing a cold chain should be stored in a refrigerator (between 28C):


vaccines, immunoglobulins, serums, insulin, ergometrine, oxytocin, dinoprostone,
certain laboratory tests, etc.
Storing medical materials/supplies

Given the diversity of items, do not to use alphabetical ordering, but group
articles by category: injections, dressings, sutures, reagents and laboratory
material, etc.
Storing bulky materials

Put a few boxes in their normal place and, on a label, indicate where the rest of the
stock is kept. Do not disperse the rest of the stock in several places.
302

Organisation and management of a pharmacy

The storage arrangement should allow a visual stock check:


It should be possible to quickly count the number of boxes for each product
and evaluate, in a few minutes, the number of weeks or months that can be
covered with the stock available.
An empty space behind a label immediately shows that the product is out of
stock.
Only a few hours should be needed to perform a complete inventory.

Management of a pharmacy
Organisation of activities

The management of the pharmacy should be entrusted to a single person having


received adequate training. This person is the only person possessing keys to the
pharmacy and narcotics cupboard and is helped by one or more assistants,
depending on the workload.

Tasks and responsibilities should be clearly defined. One assistant should be able to
replace the person in charge if necessary.
It is important to draw up a work calendar (orders, distributions, inventories,
management of expired drugs, etc.) in order to spread out the workload.

Stock management
Stock cards

The stock card is the principle instrument for stock control. A stock card is
established for each product (drugs and supplies) and updated at each movement.
Stock cards are used to:
identify all stock movements: in and out;
determine at any moment the theoretical level of stocks;
followup the consumption of different facilities;
correctly plan and prepare orders;
determine losses (differences between theoretical stock and actual stock).

The following should be noted on stock cards:


the INN, form and strength;
all movements (in, out, origin, destination, loss due to expiration, damages) and
dates;
inventories and dates.
303

Organisation and management of a pharmacy

The following may also be included:


average monthly consumption;
stock levels: buffer stock, running stock;
other stock areas for a product;
unit price;
current orders and dates.

Quantities in and out are always recorded in units (e.g. 5,000 tablets, 80 ampoules) and
never in number of boxes.
Write a single operation per line, even if several operations take place the same day.
Item: AMOXICILLIN
Code:

AMC = 9,000
Date

Origin/Destination

01/02/12 Brought forward

(previous stock card)

01/02/12 Central warehouse


02/02/12 Health centre 1
06/02/12 Health centre 2
06/02/12 Health centre 3
01/03/12 Inventory

Example of a stock card

Strength/Form: 250 mg, tab

Packaging unit: box 1,000 tab


IN
80,000

OUT

5,000
2,000
2,000

02/03/12 Health centre 1

6,000

05/03/12 Health centre 3

1,000

05/03/12 Health centre 2


31/03/12 Expired March 12
01/04/12 Health centre 1
06/02/12 Health centre 2
06/02/12 Health centre 3

2,000
1,000
6,000
1,000
2,000

STOCK
20,000

100,000
95,000

Remarks/Signature
Exp. 08/2014

93,000
91,000
91,000
85,000

10,000 (03/12) 11,000 (01/13)


70,000 (08/14)

83,000
82,000
81,000
75,000

Exp. 03/2012

74,000
72,000

Note: stock cards are always required, even when computer assisted stock
management is used.
304

Organisation and management of a pharmacy

Quantities to retain and order (stock level)


Average monthly consumption (AMC)

Calculated from outgoing stock recorded on stock cards: add the quantities of several
months (3, 6 or 12) in the out column and divide the total by the number of months
considered.
Running stock = consumption between two supply deliveries

Running stock corresponds to the quantity of each drug consumed between two
supply deliveries (e.g. if deliveries are quarterly, running stock = AMC x 3).
Buffer stock

This stock is planned to compensate for possible late deliveries, losses, and increases
in consumption. It is calculated according to the delivery delay of orders.

Buffer stock quantities are generally evaluated as half of the consumption during the
period between two deliveries. It depends on risks that a programme may run: stock
ruptures or drug expiration in specific situations (resources, seasonal supply
problems, etc.).
For example, if the delivery delay is two months, the buffer stock corresponds to the
quantity consumed in one month.
Quantities to be ordered

Quantities to order are based on data from stock cards:


actual stock level (inventory) on the day of the order
running stock
buffer stock
delay period between order and delivery
orders not yet delivered
Order = (running stock + buffer stock + probable consumption during delivery
delay) (inventory + orders not yet delivered).

Order forms

Concerning orders from peripheral facilities to the central pharmacy, it is


recommended to use pre-printed order forms which indicate the INN, form (tablet,
capsule, vial, ampoule, etc.) and strength.
The following may also be included:
stock levels,
AMC.

Orders should be in triplicate, dated and countersigned by persons in charge of


health structures. Two copies are sent to the supplier: one serves as a way bill and
may also be used for invoicing, the second stays with the supplier. The third copy
stays at the health facility.
305

Organisation and management of a pharmacy

E.g.: health facility order form, 6-month supply period, minimum stock of 3 months (2 month
delivery delay + 1 month buffer stock)

Health structure: Bangui

Head of structure: Dounia Dekhili, Ph


Date: 08.06.12
NAME

ORAL DRUGS

ACETAZOLAMIDE

ACETYLSALICYLIC ACID
ASCORBIC ACID

ALUMINIUM HYDROXYDE
AMOXICILLIN

CHLORAMPHENICOL

PREPARATION

tab 250 mg
tab 300 mg
tab 250 mg
tab 500 mg
tab 250 mg
tab 250 mg

Signature: XXX
Price

Stock

Monthly
consump.

Qty
ordered

0.01

55,000

10,000

5,000

0.03

15,000

6,000

21,000

0.09

3,000

500

0.14
0.04
0.18

16,000

4,000

Qty
delivered

8,000

Receiving orders

All orders should be accompanied by a way bill or invoice and packing list.

On reception, the number of parcels should be checked, then their contents should be
verified:
ensure that products delivered correspond to products ordered, and that the
quantities conform to those on the packing list;
packaging, labelling and expiry dates of each product should be checked, as well
as the aspect of the product;
look for special storage conditions (cold chain).
The supplier should be notified of all irregularities.

Then, drugs and material are integrated into stocks at their designated places.
Incoming quantities are recorded on stock cards.

Way bills, invoices and packing lists are to be classed with orders in an "orders" file
and kept for 3 years or more according to current regulations.
306

Organisation and management of a pharmacy

Inventory

An inventory of current stock quantities and expiry dates should be done before each
order.

Stock cards give a theoretical figure of stock quantities, but actual quantities of each
product should be verified (physical stock). Differences may arise due to errors in
recording or due theft. These differences should be clarified.

An inventory may only be easily done if the pharmacy is correctly arranged. It is an


indispensable task.
During an inventory there should be no stock movements, i.e. incoming or outgoing
stock.

Distribution

Distribution to health facilities

Each health facility sends the central warehouse two copies of the order form.
On both copies, actual quantities supplied by the central warehouse are recorded in
the Qty delivered column.
One on these copies is sent with the delivery.
After verifying that all products have been correctly recorded on their respective
stock cards, the second copy is placed in a file established for health facility. The exit
date on the stock card should be the same as the date on the order form.
Dispensing drugs to patients

Drug packaging should be presentable. Use plastic bags that can be resealed by
pressure (Minigrip).
Prepare labels for each drug, clearly showing:
the name of the drug (INN), form and strength;
the dosage written out in full or in symbols.
Put the number of tablets corresponding to a complete treatment and the label into
the bag.

In busy centres it is better to have two people responsible for dispensing drugs in
order to double check prescription deliveries; the first collects the drugs prescribed,
the second verifies and gives them to patients with all necessary explanations,
slightly away from other patients.
So that patients correctly follow treatment, adequate explanations should be given:
how to take the drug,
for how long,
possible adverse effects (e.g. drowsiness caused by anti-histamines),
precautions to be taken (e.g. avoid alcohol with metronidazole).

Persons dispensing drugs should be able to give patients the information they need.
Interpreters are needed if several languages exist in the same region.

307

Organisation and management of a pharmacy

Donations of recuperated medicines and medical samples

It is not recommended to solicit or accept supplies coming from collections of drugs


recuperated from consumers in industrialised countries, or free samples distributed
by manufacturers.
They are very often specialised drugs unknown to prescribers and unsuitable for
local pathologies. The multiplication of different drugs supplied interfere with the
implementation of standardised therapeutic regimens and makes any form of
management impossible.

308

Drug quality and storage

Drug quality and storage

Quality standards

Storage conditions
Deterioration
Expiration

Drug quality influences treatment efficacy and safety. Quality depends on correct
manufacturing and storage: high-quality drugs are available when using rational
buying procedures and when suppliers are reliable. It is also essential to assure
optimum transportation and storage conditions.

Quality standards

Each drug is characterised by particular norms written in pharmacopoeia or files


presented by manufacturers and recognised by competent authorities in each
country. These norms concern aspects (colour, odour, etc.), physicochemical
properties, analysis procedures, shelf life and storage conditions.

Analysis certificates guarantee that products from one batch (products from the
same production cycle) conform to official quality standards in the country of
manufacture. These certificates are provided for each product by manufacturers.
Every unit (box and bottle) should be clearly labelled; each label should clearly
indicate the:
INN,
form and dosage,
number of units (tablets, ampoule, etc.) or the volume (syrup, etc.),
name and address of the manufacturer,
batch number,
expiry date.

Storage conditions

Stability of drugs depends on both environmental factors such as temperature, air,


light and humidity, and drug-related factors such as the active ingredient itself, the
dosage form (tablet, solution, etc.) and the manufacturing process. It is therefore
309

Drug quality and storage

necessary to respect storage instructions given in this guide or by manufacturers (on


notices and labels) if the recommendations are not identical.

Temperature

The temperature in the store should not be above 30C.

Storage temperatures are defined by European pharmacopoeia as follows:


freezer
- 15 to
0C
refrigerator
+ 2 to + 8C
cool
+ 8 to + 15C
ambient temperature + 15 to + 30C

During transit and transportation temperatures may attain 50 to 60C inside vehicles,
shipping containers or on docks and, in this case, shelf life and expiry dates may no
longer be guaranteed.
Freezing may be detrimental, particularly for solutions, leading to the precipitation
of active ingredients or the shattering of ampoules.
Vaccines, immunoglobulins and antisera are products that are sensitive to heat and
light. Even though new techniques produce vaccines that are less sensitive to heat
(called "thermostable"), they still have to be stored in the refrigerator between 2C
and 8C, and the cold chain must be strictly respected during transport.

The vaccine vials may have a heat-sensitive monitor (VVM). The square on the
monitor changes colour when exposed to heat over a period of time: if the square is
lighter than the circle, the vaccine can be used. If the square is the same colour or
darker than the circle, the vial must be destroyed.
Vials of oral polio (OPV), measles, tuberculosis (BCG), yellow fever, hepatitis B,
tetanus (TT) and diphtheria-tetanus-pertussis (DTP) vaccines may have a VVM.

Air and humidity

In a store, relative humidity should not be above 65% (there are several devices for
humidity measurement).

Air is a factor of deterioration due to its content of oxygen and humidity. All
containers should remain closed. In airtight and opaque containers (hospital type),
drugs are protected against air and light. Opening containers long before the use of
drugs should be avoided.

Patients should be informed that tablets should not be removed from blisters until
immediately before administration.

Light

Drugs should be protected from light, particularly solutions. Parenteral forms should
be preserved in their packaging. Coloured glass may give illusory protection against
light.

310

Drug quality and storage

Deterioration

It is important to be familiar with the normal aspects of each drug (colour, odour,
solubility, consistency) in order to detect changes, which may indicate its
deterioration. It is important to know that deterioration does not always lead to a
detectable external modification.
The principal consequence of deterioration is a reduction of therapeutic activity, which
leads to more or less grave consequences for the individual and/or community.
For example, the use of expired antibacterials does not cure an infection and also
favours the emergence of resistant strains.
It is not recommended to compensate for a possible reduction of activity by a
random increase in the usual dose, as there is a real danger of overdose when using
toxic drugs.

In time, certain drugs undergo a deterioration leading to the development of


substances much more dangerous, thus an increase in toxicity. Tetracycline is the
principal example: the pale, yellow powder becomes brownish and viscous, its use
therefore being dangerous even if before the expiry date.
An increase in allergen strength has been observed in certain drugs such as penicillins
and cephalosporins.

Suppositories, pessaries, creams and ointments that have been melted under heat
should not be used. The active ingredient is no longer distributed in a homogenous
manner.
Oral rehydration salts may be used as long as they keep their aspect of white
powder. Humidity transforms them into a compact mass, more or less brownish and
insoluble. They are therefore unfit for consumption, whatever their expiry date.

Expiration
Drugs deteriorate progressively and according to various processes, even if stored in
adequate conditions. In most countries, regulations impose an obligation on
manufacturers to study the stability of their products in standardised conditions and
to guarantee a minimum shelf life period. The expiry date indicated by
manufacturers designates the date up to and including which the therapeutic effect
remains unchanged (at least 90% of the active ingredient should be present and with
no substantial increase in toxicity).
The expiry date indicated on the label is based on the stability of the drug in its
original and closed container. Shelf life period currently guaranteed is from 3 to
5 years. Less stable substances are only guaranteed for 1 or 2 years.
The expiry date should be indicated on the label with storage instructions.

311

Drug quality and storage

Expired drugs

Expiry dates are to be respected due to legal obligations and considerations of


therapeutic responsibility.

In cases where the only available drugs have expired, a doctor may be led to take on
the responsibility of using these drugs.

It is evident that a drug does not become unfit for consumption the day after its
expiry date. If a product has been stored in adequate conditions (protected from
humidity and light, packaging intact and at a medium temperature) and if
modification of aspects or solubility have not been detected, it is often preferable to
use the expired drug than to leave a gravely ill patient without treatment.
Expiry dates for drugs that require very precise dosage should be strictly respected
due to a risk of under-dosage. This is the case for cardiotonic and antiepilectic drugs,
and for drugs that risk becoming toxic, such as cyclines.

Destruction of expired or unusable drugs and material

It is dangerous to throw out expired or unusable drugs or to bury them without


precaution. For more information about destruction of drugs and material see
"Interagency Guidelines For Safe Disposal of Unwanted Pharmaceuticals in and after
emergencies", WHO/99.2.

312

Prescription, cost, compliance

Prescription, cost, compliance


SOME SUGGESTIONS FOR

Reducing risks - Reducing costs - Facilitating compliance

Limiting the use of injectable drugs

Limiting the use of syrups and oral supensions


Studying the choice of treatment regimens

Considering non-essential drugs and placebos


It is possible to promote a more rational use of medicines, as much for safety as for
cost, by a judicious choice of therapeutic regimens and the resulting lists of
medicines.

Limiting the use of injectable drugs

Numerous patients demand treatment with injectable drugs, which they imagine to
be more effective. Certain prescribers also believe that injections and infusions are
more technical acts and thus increase their credibility.
Parenteral treatment is always more costly than oral treatment. The price of the drug
itself is higher for an equal dose of active ingredient. It requires costly disposable
material. It exposes patients to complications due to poorly tolerated products
(abscesses, necrosis due to IM quinine injections or antibacterials, etc.) or badly
performed injection techniques (symptoms of overdose after a IV injection given too
rapidly, sciatic nerve damage, etc.). If disposable injection supplies are re-used, there
is a risk of bacterial or viral contamination (tetanus, hepatitis, HIV, etc.).
When both oral and injectable drugs are equally effective, parenteral administration
is only justified in case of emergency, digestive intolerance or when a patient is
unable to take oral medication. Oral drugs should replace injectable drugs as soon as
possible during the course of treatment.

313

Prescription, cost, compliance

Limiting the use of syrups and oral suspensions

Taking liquid drugs is often easier, especially for young children and more so if they
are sweetened or flavoured. It is, however, recommended to limit their use for
numerous reasons:
Risk of incorrect usage

Outside of hospitals, determining the correct dosage is hazardous: spoons never


contain standard volumes (soup spoons, dessert spoons, tea spoons). Oral
suspensions should be prepared with a specified amount of clean water, and well
shaken prior to administration. There is therefore a risk of overdose or giving an
insufficient dosage.

Some oral suspensions must be kept refrigerated; their storage at room


temperature is limited to a few days, and with syrups there is a risk of
fermentation.
In numerous countries syrups are thought of as "cough medicine". Confusion
between cough mixtures and antibacterial suspensions or syrups is common.

Economic considerations

Compared to the price of tablets or capsules, the price of syrups and oral
suspensions is considerably higher. Even using a powder for subsequent
reconstitution, the costs may be 2 to 7 times higher than an equivalent dose due
to the cost of the bottle itself and higher transportation costs due to weight and
volume.

Studying the choice of treatment regimens

The choice of a treatment regimen often influences compliance and cost. The shortest
and least divided (1 to 2 doses per day) treatments are most often recommended.
Single dose treatments are ideal, when indicated.
For the treatment of malaria, tuberculosis and HIV infection, fixed-dose
combinations (coformulated tablets) should preferably be used in order to improve
compliance.

Considering nonessential medicines and placebos

In developing countries as in industrialised countries, patients with psychosomatic


complaints are numerous. The problems that motivate their consultations may not
necessarily be remedied with a drug prescription. Is it always possible or desirable to
send these patients home without a prescription for a symptomatic drugs or
placebo? If so, what placebo should be prescribed?
314

Prescription, cost, compliance

When national drug policy is strict and allows neither the use of placebos nor nonessential symptomatic drugs, other products are often used in an abusive manner,
such as chloroquine, aspirin, and even antibacterials.

Conversely, a placebo may take the place of an effective and needed drug. This risk is
real, but seems less frequent, which makes the introduction of placebos on a list of
essential drugs relevant. Multivitamins may present a type of harmless and
inexpensive placebo. Their composition generally corresponds to preventive
treatment of vitamin deficiency and they have no contraindications.

Numerous nonprescription drug products (tonics, oral liver treatments presented in


ampoules) have no therapeutic value and, due to their price, cannot be used as
placebos.

315

Use of antibacterials

Use of antibacterials

Possible causes of antibacterial treatment failure


Choosing an antibacterial treatment
Antibacterial combinations

Principal antibacterial groups

In peripheral health facilities, the diagnosis of an infection is based essentially on


clinical criteria, as laboratory testing (culture, isolation and identification of bacteria)
is rarely available.
The choice of treatment protocol depends on the context in which the patient is
examined:

Dispensaries: numerous patients examined rapidly and difficult to follow. Standard


protocols should be drawn up for diagnosis and treatment of the most frequent
infections. The number of available antibacterials is limited.
Medical centres and hospitals: the number of available antibacterials is greater,
alternatives are possible in the event of failure or intolerance to first line treatment.

Possible causes of antibacterial treatment failure

Clinical signs that are in fact due to viral or parasitic infections


Choice of antibacterial that penetrates poorly into infected tissues (abscess,
cerebrospinal fluid)
Insufficient dosage and/or treatment duration
Poor treatment compliance
Vomiting after oral ingestion
Drug interactions reducing absorption (e.g. simultaneous administration of
antacids)
Inactivation of an antibacterial after mixing several drugs in the same infusion
bottle
Use of antibacterial that has expired or that has deteriorated due to poor storage
conditions (most antibacterials become only ineffective, except expired
tetracyclines that become toxic to the kidneys)
Bacterial resistance to the antibacterial

317

Revised February 2015


Use of antibacterials

Choosing an antibacterial treatment

The table below summarises the choice of antibacterials appropriate both for their
penetration into the infected tissue and the most probable bacteria.
Infections

Upper respiratory tract


infections

First choice

Tonsillitis

benzathine benzylpenicillin

Diphtheria

benzathine benzylpenicillin

Sinusitis

amoxicillin

Epiglottitis

ceftriaxone

Lower respiratory tract amoxicillin


infections
Acute otitis media
amoxicillin
Intestinal infections
Typhoid fever

ciprofloxacin

Upper

ciprofloxacin

Shigellosis

Urinary tract infections


Lower

Urethritis and
cervicitis
Genital ulcers
Syphilis

Chancroid

Upper genital tract


infections

ciprofloxacin
ciprofloxacin

azithromycin + ceftriaxone
or azithromycin + cefixime
benzathine benzylpenicillin
azithromycin

Other possible
first-line treatments

penicillin V or amoxicillin
or erythromycin or azithromycin
(in penicillin-allergic patients only)
penicillin G procaine
or erythromycin
chloramphenicol
erythromycin

ceftriaxone
or ampicillin + gentamicin
erythromycin or azithromycin
(in penicillin-allergic patients only)
cefixime

ceftriaxone

cefixime or ceftriaxone
or ampicillin + gentamicin
cefixime or nitrofurantoin

doxycycline + ceftriaxone
or doxycycline + cefixime
or erythromycin + ceftriaxone
or erythromycin + cefixime
doxycycline or erythromycin
ceftriaxone or ciprofloxacin
or erythromycin

Sexually transmitted cefixime + doxycycline


ceftriaxone or spectinomycin
or erythromycin + metronidazole + doxycycline or erythromycin
+ metronidazole
Post-partum

Meningococcal
meningitis
Eye infections

amoxicillin/clavulanic acid
+ gentamicin
ceftriaxone

Bacterial conjunctivitis tetracycline eye ointment


Trachoma

318

azithromycin

ampicillin + gentamicin
+ metronidazole
ampicillin

chloramphenicol eye drops

erythromycin
or tetracycline eye ointment

Use of antibacterials

Antibacterial combinations

Combining several antibacterials is only justified in severe infections (brucellosis,


leprosy, tuberculosis, pelvic inflammatory disease, etc.).

Certain combinations should be avoided, as the action of one antibacterial can


neutralise the action of another antibacterial administered simultaneously (e.g.
penicillins and tetracyclines).

Principal antibacterial groups


Penicillin and derivatives

Amoxicillin and ampicillin


Benzylpenicillin (penicillin G)
Benzathine benzylpenicillin (penicillin G benzathine)
Procaine benzylpenicillin with or without benzylpenicillin
Cloxacillin
Phenoxymethylpenicillin (penicillin V)

Fast-acting penicillins

Benzylpenicillin should be reserved for treating severe acute infections. Due to


rapid elimination, an injection every 4 to 6 hours is required, which is impossible if
the patient is not hospitalised.
Oral phenoxymethylpenicillin is used in the treatment of tonsillitis.
Long-acting penicillins

Benzathine benzylpenicillin has a concentration that slowly increases in the


24 hours following the injection. It remains active for 15 to 20 days. Due to its
delayed action and low concentration in the blood, its use is restricted to infections
susceptible to penicillin that evolve slowly (e.g syphilis). Its use is contra-indicated
in acute infections. It is only administered by IM route.
Procaine benzylpenicillin has the advantage of being injected only once daily. It
acts rapidly (45 to 60 minutes) and is only administered by IM route.

The combination of procaine benzylpenicillin and benzylpenicillin is also known


as fortified penicillin procaine (PPF). It acts within 15 to 30 minutes after injection,
thus more rapidly than procaine benzylpenicillin alone due to the presence of
benzylpenicillin. It is only administered by IM route.
Penicillin derivatives

Amoxicillin and ampicillin are broad-spectrum antibacterials with good tissue


penetration and are therefore used for many infections. They are frequently used
in pregnant women, for whom other antibacterials may be contra-indicated.
319

Revised February 2015


Use of antibacterials

Amoxicillin is better absorbed through the intestinal tract than ampicillin and
therefore requires lower oral doses.
For oral administration, use amoxicillin rather than ampicillin. On the other hand,
injectable ampicillin is preferable to injectable amoxicillin. Injectable forms should
be reserved for severe infections only.

Cloxacillin is a narrow-spectrum antibacterial, essentially limited to treatment of


staphylococcal infections, most of which have become resistant to penicillin.

Cephalosporins
Cefixime
Ceftriaxone

Cefixime and ceftriaxone are third-generation cephalosporins particularly active


against Gram-negative bacteria. These are an alternative to fluoroquinolones,
especially in children and pregnant women.

Macrolides

Erythromycin
Azithromycin

Erythromycin is reserved for penicillin-allergic patients.

Azithromycin is effective as a single-dose for the treatment of Chlamydia


trachomatis infections, due to its prolonged half-life.

Chloramphenicols
Chloramphenicol

Chloramphenicol is a broad-spectrum antibacterial, effective against numerous


infections. Due to its effectiveness and low cost, it is still widely used. However, due
to its potential haematotoxicity, its use should be restricted to severe infections when
other less toxic antibacterials are not effective or are contra-indicated.
Oral treatment is more effective than parenteral treatment: blood and tissue
concentrations are higher when chloramphenicol is given orally.

Sulphonamides

Sulfadiazine
Sulfadoxine
Cotrimoxazole (sulfamethoxazole/trimethoprim)

Simple sulphonamides

Sulfadiazine in combination with pyrimethamine is the first-line treatment of


toxoplasmosis.

Sulfadoxine is a long-acting sulphonamide (approximately one week). Due to the


existence of resistant strains it should not be used for meningitis or cholera
epidemics.
The use of non-absorbable sulphonamides (sulfaguanidine, etc.) is not
recommended, as they are ineffective in the majority of intestinal bacterial
infections.
320

Use of antibacterials

Combined sulphonamides

The combination of sulfamethoxazole and trimethoprim (cotrimoxazole) benefits


from the synergic effect of both active ingredients. Indications are more numerous
than for sulphonamides alone. However, there are an increasing number of strains
resistant to cotrimoxazole.

Tetracyclines

Doxycycline
Tetracycline

Due to the multiplication of organisms resistant to tetracyclines, their use should


be reserved for specific infections: brucellosis, cholera, relapsing fevers, typhus,
chlamydial infections and certain pneumopathies.
Doxycycline has the advantage of being administered in a single dose for the
treatment of cholera, epidemic typhus and louse-borne relapsing fever.

Aminoglycosides
Gentamicin
Spectinomycin
Streptomycin

Due to their renal and auditory toxicity, aminoglycosides should only be prescribed
for their specific indications and ensuring the monitoring of renal and auditory
function.

Quinolones

Nalidixic acid
Ciprofloxacin, ofloxacin, etc.

First generation quinolones: nalidixic acid


Nalidixic acid is no longer recommended for the treatment of shigellosis. It may be
used for the treatment of cystitis, only in the absence of a better option.

Second generation quinolones (fluoroquinolones): ciprofloxacin, ofloxacin, etc.


Fluoroquinolones have a broader antibacterial spectrum than first-generation
quinolones and have good tissular penetration. Ciprofloxacin is used as first-line
treatment in shigellosis, typhoid fever or certain urinary tract infections.

Nitrofuranes

Nitrofurantoin

Nitrofurantoin may be prescribed in cystitis, particularly in young women, except


during the last month of pregnancy.

321

Antiseptics and disinfectants

Antiseptics and disinfectants


Definition
Selection

Preparation and use of antiseptic solutions

Preparation and use of disinfectant solutions

Definition

Antiseptics are used to kill or eliminate microorganisms and/or inactivate virus on


living tissues (intact or broken skin and mucous membranes).
Disinfectants are used to kill or eliminate microorganisms and/or inactivate virus on
inanimate objects and surfaces (medical devices, instruments, equipment, walls,
floors).
Certain products are used both as an antiseptic and as a disinfectant (see specific
information for each product).

Selection
Recommended products
1) Core list

No single product can meet all the needs of a medical facility with respect to
cleaning, disinfection and antisepsis. However, use of a limited selection of products
allows greater familiarity by users with the products in question and facilitates stock
management:
ordinary soap
a detergent and, if available, a detergent-disinfectant for instruments and a
detergent-disinfectant for floors and surfaces
a disinfectant: chlorine-releasing compound (e.g. NaDCC)
an antiseptic: 10% polyvidone iodine or chlorhexidine
2) Complementary list

Other products can be used, according to the activities carried out, resources, and
options for obtaining the product, locally or otherwise:

Ethanol and isopropanol


By virtue of its rapid action (< 30 seconds), alcohol, if available locally, is useful to
disinfect:
intact skin, before taking a blood sample or performing an injection (except
vaccines),
latex stoppers of drug vials.

323

Antiseptics and disinfectants

Alcohol acts faster than polyvidone iodine, but its duration of action is shorter.

Alcohol can only be used on intact skin. Application to mucous membranes or


broken skin is contra-indicated, however, alcohol may be used on broken skin in
the event of accidental exposure to blood.
Alcohol is more effective at 60-70% concentration than at 90-95%.

Alcohol-based hand rubs

Alcohol-based hand rubs (ABH) are used for hand antisepsis. Some, but not all,
ABH may also be used for surgical hand antisepsis.

Not all ABH preparations are equivalent. For example, for antiseptic hand rub,
depending on the product specifications:
Bactericidal effect may be achieved with a single application of 30 seconds duration,
or 2 consecutive applications of 30 seconds each, or a single application of 60 seconds
duration.
The volume of rub required per application may be 3 or 5 ml.

Thus, when purchasing locally, it is important to verify the quality of the product
and specific instructions for use (number of applications, duration of application,
and volume to be used per application).
For surgical activity, ensure that the product is suitable for use as a surgical hand
rub. Follow manufacturers instructions for use.
All alcohols and alcohol-based products are flammable. Precautions should be
taken during storage and use to avoid contact with a heat source (flame,
electrocautery, etc.)

Polyvidone iodine (PVI) scrub solution

7.5% or 4% PVI scrub solution is used for antiseptic cleansing of healthy skin,
contaminated wounds and surgical site, as well as antiseptic hand wash and
surgical hand wash.
Given the possible interactions between different groups of antiseptics, antiseptic
cleansing and antisepsis should only be carried out using products from the same
class. For example, for pre-operative skin preparation, PVI scrub solution is used
for cleansing, then PVI 10% dermal solution is used for antisepsis.

Glutaraldehyde (2% solution)

Glutaraldehyde is used for high-level disinfection of heat-sensitive items,


which cannot withstand heat sterilisation, notably endoscopes/endoscopy
equipment.

Instructions for glutaraldehyde use must be followed scrupulously: 1) two


preliminary washes of the equipment through immersion in a detergentdisinfectant solution for instruments, followed each time by rinsing;
2) complete immersion of the equipment in a 2% glutataldehyde solution for
20 minutes; 3) thorough final rinsing, with filtered water (or sterile water for
endoscopes introduced into a sterile cavity) to eliminate any residue;
4) thorough drying with a sterile towel; 5) sterile wrapping and use within
24 hours.

324

Antiseptics and disinfectants

Glutaraldehyde is available as 2% ready-to-use solution (e.g. Korsolex RTU,


Steranios 2%); concentrated solution that must be diluted to obtain a 2% solution
(e.g. 25% or 38.5% solutions); preparations requiring activation (alkalinisation)
before use, through addition of the agent provided with the product (e.g. Cidex,
Glutrex).

Glutaraldehyde solution is irritating to skin and mucous membranes, and releases


toxic vapours. Personnel exposed to glutaraldehyde should take precautions to
protect skin and eyes and avoid inhalation of vapours (risk of nausea, headache,
breathing disorders, rhinitis, eye irritation, dermatitis).
Glutaraldehyde solutions are flammable. Precautions should be taken during
storage and use to avoid contact with a heat source.

Non-recommended products

Hydrogen peroxide (3% or 10 volumes) has limited efficacy as antiseptic agent but
can be useful to clean contaminated wounds. In addition, concentrated solutions
are dangerous to transport and handle.

Mercury compounds such as phenylmercuric borate, merbromin


(Mercurochrome), mercurobutol (Mercryl), thimerosal (Merthiolate,
Timerosal) have limited efficacy, may cause serious adverse effects (toxic for
kidneys, central nervous system and digestive tract; allergies) and pollute the
environment. Their use must be abandoned.
Hexachlorophene is toxic for the central nervous system and its efficacy is limited.
Ether is often wrongly used as an antiseptic; it removes sticky residues of plaster.
Eosin is a drying agent, often wrongly used as an antiseptic.

None of these products is included in the WHO list of essential medicines.

Preparation and use of antiseptic solutions


Preparation

Aqueous solutions of many antiseptics can be contaminated by pathogens (especially


Pseudomonas aeruginosa) during handling.
To avoid this, the following precautions must be taken:

Prepare all aqueous antiseptic solutions with clean water that has been boiled for a
few minutes and cooled.
Replace all aqueous solutions at least once a week.

Only prepare small amounts at a time to avoid wastage and the temptation to keep
expired solutions.
Never mix a fresh solution with a leftover solution.

325

Antiseptics and disinfectants

Wash bottles with hot water and leave to dry before each refill.

Never use a cork stopper (it promotes contamination; cork inactivates certain
antiseptics such as chlorhexidine).
Mark on the bottles:
the name of the product
its concentration
the date of preparation or the date of expiry

Every medical facility should define a clear policy concerning the renewal of
antiseptic solutions.

Use

Do not use antiseptic solutions belonging to different classes for the same
procedure: incompatibilities between different compounds exist.

Antiseptics should be used when wounds are contaminated or infected. Clean,


non-infected wounds may be cleaned with 0.9% sodium chloride; it is not
necessary to apply an antiseptic.
In case of accidental exposure to blood (needlestick or broken skin): the injured
area should be washed well with soap and water. No evidence exists that
antiseptics reduce the risk of transmission, however, their use after thorough
cleaning is not contraindicated. Use 2.6% bleach diluted 1/5 or 1/10, or 70%
alcohol, or 10% polyvidone iodine solution and leave in contact for 5 minutes.

Disinfection of skin when administrating a vaccine is not recommended; rather,


simply clean the injection site with clean water. Certain vaccines (for example,
BCG) may be inactivated in the presence of an antiseptic. If an antiseptic is used
despite this recommendation, it must be allowed to dry before vaccine injection.

Preparation and use of disinfectant solutions

The effectiveness of disinfection can be impaired by error in preparation


(concentration, temperature), failure to follow recommended contact times, or
deterioration of the product due to poor storages conditions.

Personnel carrying out disinfection should wear protective clothing when preparing
or using disinfectant solutions: gown, rubber apron, gloves with long cuffs, goggles
and mask.

Preparation

Solutions should be prepared with clean water (chlorine solutions should be


prepared with cold water only, in non-metal containers).

Solution for disinfecting floors and surfaces: prepare just before use, and discard
any unused solution.

Solution for pre-disinfection of medical devices and instruments: replace daily. The
solution may be used for a maximum of 24 hours; if visibly soiled, discard and
replace with fresh soaking solution before 24 hours are up.
326

Antiseptics and disinfectants

Solution for disinfection of medical devices and instruments: prepare just before
and discard after use.
Do not add any product (e.g. a detergent, descaling agent) to disinfectant solutions.

Disinfection of floors and surfaces

Apply detergent-disinfectant intended for floors and surfaces1, without rinsing.


Follow manufacturer s instructions for dilution and specific preparation
procedures.
Or
After cleaning with a detergent (cleaning product without an antimicrobial agent)
and rinsing with water, apply a 0.1 % active chlorine solution. Preliminary washing
and rinsing are essential: the activity of chlorine is reduced in the presence of
organic material (sputum, vomit, faeces, blood and other body fluids), and the
detergent used may be incompatible with chlorine. Contact time is 15 minutes.
Stainless steel surfaces should be rinsed with water after disinfection with chlorine
solution.
The use of detergent-disinfectant products reduces workload (cleaning and
disinfection are carried out as a single procedure), but they have the disadvantage of
being weak detergents and leaving a film, which causes dirt to build up on the floors.
It is thus necessary to alternate their use with that of a detergent alone. Each medical
facility should establish a clear policy addressing this issue.

Disinfection of linen

After hand washing, followed by rinsing: soak the clean linen in a solution of 0.1%
active chlorine for 15 minutes and rinse thoroughly (3 rinses).
After machine-washing at 60C: soak the linen in a 0.1% active chlorine solution for
2 to 3 minutes and rinse thoroughly (3 rinses).

Pre-disinfection of reusable medical devices/instruments

After use, soak medical devices (disassembled, forceps and scissors opened):
In a detergent-disinfectant solution intended for medical devices and
instruments1. Use a syringe to irrigate the cavities of hollow devices with the
same solution. For correct dilution and soak times, follow manufacturer s
instructions; use a timer.
Or
In 0.1% available chlorine solution for 15 minutes (use a timer). Use a syringe to
irrigate the cavities of hollow devices with the solution. Comply with
recommended soaking times and concentrations (risk of corrosion of metal
instruments). Soaking for too long (> 15 minutes) and/or in a solution that is too
concentrated will increase the risk of corrosion.
Rinse with clean water, using a syringe for hollow cavities.
Dry with a clean, dry, lint-free cloth.

1 For example a quaternary ammonium detergent-disinfectant.

327

Antiseptics and disinfectants

Cleaning-disinfection of reusable medical devices/instruments


After the pre-disinfection step:

Immerse the material in a detergent-disinfectant solution intended for medical


devices and instruments 2 (for correct dilution and soak times, follow
manufacturers directions). Scrub with a soft, non-abrasive brush. Use a bottle
brush for hollow devices, or irrigate with a syringe. Rinse with clean water, drain
and dry with a clean, dry, lint-free cloth.

Or

Wash (as above) with detergent and rinse with clean water. Then soak in 0.1%
available chlorine solution for 20 minutes (use a timer). Comply with
recommended soak times and concentrations (risk of corrosion of metal
instruments). Rinse with clean water, drain and dry with a clean, dry, lint-free
cloth.

2 For example a quaternary ammonium detergent-disinfectant.

328

Annex1
19thWHOModelListofEssentialMedicines(April2015)

Explanatorynotes
Thecorelistpresentsalistofminimummedicineneedsforabasichealthcaresystem,listingthemost
efficacious,safeandcosteffectivemedicinesforpriorityconditions.Priorityconditionsareselectedonthe
basisofcurrentandestimatedfuturepublichealthrelevance,andpotentialforsafeandcosteffective
treatment.

Thecomplementarylistpresentsessentialmedicinesforprioritydiseases,forwhichspecializeddiagnostic
ormonitoringfacilities,and/orspecialistmedicalcare,and/orspecialisttrainingareneeded.Incaseofdoubt
medicinesmayalsobelistedascomplementaryonthebasisofconsistenthighercostsorlessattractivecost
effectivenessinavarietyofsettings.

Thesquareboxsymbol()isprimarilyintendedtoindicatesimilarclinicalperformancewithina
pharmacologicalclass.Thelistedmedicineshouldbetheexampleoftheclassforwhichthereisthebest
evidenceforeffectivenessandsafety.Insomecases,thismaybethefirstmedicinethatislicensedfor
marketing;inotherinstances,subsequentlylicensedcompoundsmaybesaferormoreeffective.Wherethere
isnodifferenceintermsofefficacyandsafetydata,thelistedmedicineshouldbetheonethatisgenerally
availableatthelowestprice,basedoninternationaldrugpriceinformationsources.Notallsquareboxesare
applicabletomedicineselectionforchildrenseethesecondEMLcfordetails.

Therapeuticequivalenceisindicatedonlyonthebasisofreviewsofefficacyandsafetyandwhenconsistent
withWHOclinicalguidelines.Nationallistsshouldnotuseasimilarsymbolandshouldbespecificintheir
finalselection,whichwoulddependonlocalavailabilityandprice.

Theasymbolindicatesthatthereisanageorweightrestrictiononuseofthemedicine;detailsforeach
medicinecanbefoundinTable1.1.

Wherethe[c]symbolisplacednexttothecomplementarylistitsignifiesthatthemedicine(s)require(s)
specialistdiagnosticormonitoringfacilities,and/orspecialistmedicalcare,and/orspecialisttrainingfor
theiruseinchildren.

Wherethe[c]symbolisplacednexttoanindividualmedicineorstrengthofmedicineitsignifiesthatthere
isaspecificindicationforrestrictingitsusetochildren.

ThepresenceofanentryontheEssentialMedicinesListcarriesnoassuranceastopharmaceuticalquality.It
istheresponsibilityoftherelevantnationalorregionaldrugregulatoryauthoritytoensurethateach
productisofappropriatepharmaceuticalquality(includingstability)andthat,whenrelevant,different
productsareinterchangeable.

ForrecommendationsandadviceconcerningallaspectsofthequalityassuranceofmedicinesseetheWHO
Medicineswebsitehttp://www.who.int/medicines/areas/quality_assurance.

Medicinesanddosageformsarelistedinalphabeticalorderwithineachsectionandthereisnoimplication
ofpreferenceforoneformoveranother.Standardtreatmentguidelinesshouldbeconsultedforinformation
onappropriatedosageforms.
ThemaintermsusedfordosageformsintheEssentialMedicinesListcanbefoundinTable1.2.

Definitionsofmanyofthesetermsandpharmaceuticalqualityrequirementsapplicabletothedifferent
categoriesarepublishedinthecurrenteditionofTheInternationalPharmacopoeia
http://www.who.int/medicines/publications/pharmacopoeia.

EssentialMedicines
WHOModelList

19thedition

1. ANAESTHETICS
1.1 General anaesthetics and oxygen
1.1.1 Inhalational medicines
halothane

Inhalation.

isoflurane

Inhalation.

nitrousoxide

Inhalation.

oxygen

Inhalation (medicinalgas).

1.1.2 Injectable medicines


ketamine

Injection:50 mg(ashydrochloride)/ mLin10mLvial.


Injection:10 mg/ mL;20 mg/ mL.

propofol*

*Thiopentalmaybeusedasanalternativedependingonlocal
availabilityandcost.

1.2 Local anaesthetics


Injection: 0.25%;0.5%(hydrochloride)invial.
bupivacaine

Injectionforspinalanaesthesia:0.5%(hydrochloride)in
4mLampouletobemixedwith7.5%glucosesolution.
Injection: 1%;2%(hydrochloride)invial.

lidocaine

Injectionforspinalanaesthesia:5%(hydrochloride)in
2mLampouletobemixedwith7.5%glucosesolution.
Topicalforms:2%to4%(hydrochloride).
Dentalcartridge: 2%(hydrochloride)+epinephrine1:80000.

lidocaine+epinephrine(adrenaline)

Injection:1%;2%(hydrochlorideorsulfate)+epinephrine
1:200000invial.

ComplementaryList
Injection:30mg(hydrochloride)/mLin1mLampoule.
ephedrine
(Foruseinspinalanaesthesiaduringdelivery,topreventhypotension).
1.3 Preoperative medication and sedation for short-term procedures
atropine

Injection: 1mg(sulfate)in1 mL ampoule.


Injection: 1mg/ mL.

midazolam

Oralliquid:2mg/mL[c].
Tablet:7.5mg;15mg.

morphine

Injection: 10mg(sulfate orhydrochloride)in1mLampoule.

19th WHO Model List of Essential Medicines (April 2015)

page - 1

EssentialMedicines
WHOModelList

19thedition

2. MEDICINES FOR PAIN AND PALLIATIVE CARE


2.1 Non-opioids and non-steroidal anti-inflammatory medicines (NSAIMs)
Suppository: 50mgto150mg.
acetylsalicylicacid
Tablet:100mgto500mg.
Oralliquid: 200mg/5 mL.
ibuprofena

Tablet:200mg;400mg;600mg.
a

Not in children less than 3 months.

Oralliquid: 125mg/5 mL.


Suppository:100mg.
paracetamol*

Tablet:100mgto500mg.
*Notrecommendedforantiinflammatoryusedue
tolackofprovenbenefittothateffect.

2.2 Opioid analgesics


codeine

Tablet: 30mg(phosphate).
Granules(slowrelease;tomixwithwater): 20mg
200mg(morphinesulfate).
Injection:10mg(morphinehydrochlorideor
morphinesulfate)in1mLampoule.

morphine*

Oralliquid:10mg(morphinehydrochlorideor
morphinesulfate)/5mL.
Tablet(slowrelease):10mg200mg(morphine
hydrochlorideormorphinesulfate).
Tablet(immediaterelease):10mg(morphine
sulfate).
*Alternativeslimitedtohydromorphoneand
oxycodone

2.3 Medicines for other common symptoms in palliative care


amitriptyline
cyclizine[c]

Tablet:10mg;25mg;75mg.
Injection:50mg/ mL.
Tablet:50mg.
Injection:4mg/ mL in1 mLampoule(asdisodium
phosphatesalt).

dexamethasone

Oralliquid:2mg/5mL.
Tablet:2mg[c];4mg.

19th WHO Model List of Essential Medicines (April 2015)

page - 2

EssentialMedicines
WHOModelList

19thedition

Injection:5mg/ mL.
diazepam

Oralliquid:2mg/5mL.
Rectalsolution:2.5mg;5mg;10mg.
Tablet:5mg;10mg.

docusatesodium

fluoxetinea

Capsule:100mg.
Oralliquid:50mg/5mL.
Solidoraldosageform: 20mg(ashydrochloride).
a

>8 years.

Injection: 5mgin1 mL ampoule.


haloperidol

Oralliquid:2mg/mL.
Solidoraldosageform:0.5mg;2mg;5mg.

hyoscinebutylbromide

Injection:20mg/mL.

hyoscinehydrobromide[c]

Injection:400micrograms/ mL;600micrograms/
mL.
Transdermalpatches:1mg/72hours.

lactulose[c]

Oralliquid:3.13.7g/5mL.

loperamide

Solidoraldosageform:2mg.
Injection:5mg (hydrochloride)/mLin2mL
ampoule.

metoclopramide

Oralliquid:5mg/5mL.
Solidoralform:10mg(hydrochloride).
Injection:1 mg/ mL;5 mg/ mL.

midazolam

Solidoraldosageform:7.5mg;15mg.
Oralliquid:2mg/mL[c].
Injection:2mgbase/ mL in2mLampoule(as
hydrochloride).

ondansetron[c] a

Oralliquid:4mgbase/5mL.
Solidoraldosageform:Eq4mgbase;Eq8mgbase.
a

senna

>1 month.

Oralliquid:7.5mg/5mL.

3. ANTIALLERGICS AND MEDICINES USED IN ANAPHYLAXIS


dexamethasone

Injection:4mg/ mL in1 mLampoule(asdisodium


phosphatesalt).

epinephrine(adrenaline)

Injection: 1mg(ashydrochlorideorhydrogen
tartrate)in1mLampoule.

hydrocortisone

Powderforinjection: 100mg(assodiumsuccinate)
invial.

19th WHO Model List of Essential Medicines (April 2015)

page - 3

EssentialMedicines
WHOModelList

19thedition

Oralliquid:1mg/ mL.
loratadine*

Tablet:10mg.

*Theremaybearoleforsedatingantihistaminesfor
limitedindications(EMLc).

prednisolone

Oralliquid: 5 mg/ mL [c].


Tablet:5mg;25mg.

4. ANTIDOTES AND OTHER SUBSTANCES USED IN POISONINGS


4.1 Non-specific
charcoal,activated

Powder.

4.2 Specific
Injection: 200mg/ mL in10mLampoule.
acetylcysteine
Oralliquid:10%[c];20%[c].
atropine

Injection: 1mg(sulfate)in1mLampoule.

calciumgluconate

Injection: 100mg/ mL in10mLampoule.

methylthioniniumchloride
(methyleneblue)

Injection:10mg/mLin10mLampoule.

naloxone

Injection: 400micrograms(hydrochloride)in1 mL
ampoule.

penicillamine

Solidoraldosageform: 250mg.

potassiumferrichexacyanoferrate(II)
2H2O(Prussianblue)

Powderfororaladministration.

sodiumnitrite

Injection: 30mg/ mL in10 mLampoule.

sodiumthiosulfate

Injection: 250mg/ mL in50mLampoule.

ComplementaryList
deferoxamine

Powderforinjection:500mg(mesilate)invial.

dimercaprol

Injectioninoil:50mg/mLin2mLampoule.

fomepizole

Injection:5mg/mL(sulfate)in20mLampouleor1g/
mL(base)in1.5mLampoule.

sodiumcalciumedetate

Injection:200mg/mLin5mLampoule.

succimer

Solidoraldosageform:100mg.

5. ANTICONVULSANTS/ANTIEPILEPTICS
Oralliquid: 100mg/5 mL.
carbamazepine

Tablet(chewable):100mg;200mg.
Tablet(scored):100mg;200mg.

diazepam

Gelorrectalsolution:5 mg/mLin0.5mL;2 mL; 4


mLtubes.

19th WHO Model List of Essential Medicines (April 2015)

page - 4

EssentialMedicines
WHOModelList

19thedition

lorazepam

magnesiumsulfate*

Parenteralformulation:2mg/mLin1mL
ampoule;4mg/mLin1mLampoule.
Injection: 0.5g/ mL in2 mLampoule(equivalentto
1gin2mL;50%weight/volume);0.5g/mLin
10mLampoule(equivalentto5gin10mL;50%
weight/volume).
*Foruseineclampsiaandseverepreeclampsiaand
notforotherconvulsantdisorders.
Solutionfororomucosaladministration:5mg/mL;
10mg/mL

midazolam

Ampoule*:1mg/mL;10mg/mL
*forbuccaladministrationwhensolutionfor
oromucosaladministrationisnotavailable
Injection:200mg/ mL (sodium).

phenobarbital

Oralliquid:15mg/5mL.
Tablet:15mgto100mg.
Injection: 50mg/ mL in5 mLvial(sodiumsalt).
Oralliquid:25mgto30mg/5mL.*
Solidoraldosageform:25mg;50mg;100mg
(sodiumsalt).

phenytoin

Tablet(chewable):50mg.
*Thepresenceofboth25mg/5mLand30mg/5mL
strengthsonthesamemarketwouldcauseconfusion
inprescribinganddispensingandshouldbe
avoided.
Oralliquid: 200mg/5 mL.

valproicacid(sodiumvalproate)

Tablet(crushable):100mg.
Tablet(entericcoated):200mg;500mg(sodium
valproate).

ComplementaryList
Capsule:250mg.
ethosuximide
Oralliquid:250mg/5mL.
valproicacid(sodiumvalproate)

Injection:100mg/mLin4mLampoule;100mg/mL
in10mLampoule.

6. ANTI-INFECTIVE MEDICINES
6.1 Anthelminthics
6.1.1 Intestinal anthelminthics
albendazole

Tablet(chewable): 400mg.

19th WHO Model List of Essential Medicines (April 2015)

page - 5

EssentialMedicines
WHOModelList

19thedition

levamisole

Tablet: 50mg;150mg(ashydrochloride).

mebendazole

Tablet(chewable): 100mg;500mg.

niclosamide

Tablet(chewable): 500mg.

praziquantel

Tablet: 150mg;600mg.
Oralliquid: 50mg(asembonateorpamoate)/ mL.

pyrantel

Tablet(chewable):250mg(asembonateor
pamoate).

6.1.2 Antifilarials
albendazole

Tablet(chewable): 400mg.

diethylcarbamazine

Tablet: 50mg;100mg(dihydrogencitrate).

ivermectin

Tablet(scored): 3mg.

6.1.3 Antischistosomals and other antitrematode medicines


praziquantel

Tablet: 600mg.

triclabendazole

Tablet: 250mg.

ComplementaryList
Capsule:250mg.
oxamniquine*

Oralliquid:250mg/5mL.
*Oxamniquineislistedforusewhenpraziquantel
treatmentfails.

6.2 Antibacterials
6.2.1 Beta-lactam medicines
Powderfororalliquid: 125mg(astrihydrate)/5
mL;250mg(astrihydrate)/5mL[c].
amoxicillin
Solidoraldosageform:250mg;500mg(as
trihydrate).

amoxicillin+clavulanicacid

Oralliquid: 125 mgamoxicillin+31.25mg


clavulanicacid/5mLAND250mgamoxicillin+
62.5mgclavulanicacid/5mL[c].
Tablet:500mg(astrihydrate)+125mg(as
potassiumsalt).

ampicillin

Powderforinjection: 500mg;1g(assodiumsalt)in
vial.

benzathinebenzylpenicillin

Powderforinjection: 900 mgbenzylpenicillin


(=1.2millionIU)in5mLvial[c];1.44g
benzylpenicillin(=2.4millionIU)in5mLvial.

benzylpenicillin

Powderforinjection: 600mg(=1millionIU);3g(=
5millionIU)(sodiumorpotassiumsalt)invial.

19th WHO Model List of Essential Medicines (April 2015)

page - 6

EssentialMedicines
WHOModelList

cefalexin[c]

19thedition

Powderforreconstitutionwithwater:125mg/5
mL;250mg/5mL(anhydrous).
Solidoraldosageform:250mg(asmonohydrate).
Powderforinjection:1g(assodiumsalt)invial.

cefazolin*a

*Forsurgicalprophylaxis.
a

>1 month.

Capsule: 400mg (astrihydrate).


cefixime*

*Listedonlyforsingledosetreatmentof
uncomplicatedanogenitalgonorrhoea.
Powderforinjection: 250mg;1g(assodiumsalt)in
vial.

ceftriaxone*a

*Donotadministerwithcalciumandavoidin
infantswithhyperbilirubinaemia.
a

>41 weeks corrected gestational age.

Capsule: 500mg;1g(assodiumsalt).
cloxacillin

Powderforinjection:500mg(assodiumsalt)in
vial.
Powderfororalliquid:125mg(assodium
salt)/5mL.

phenoxymethylpenicillin

Powderfororalliquid: 250mg(aspotassium
salt)/5mL.
Tablet:250mg(aspotassiumsalt).
Powderforinjection: 1g(=1millionIU);3g
(=3millionIU)invial.

procainebenzylpenicillin*

*Procainebenzylpenicillinisnotrecommendedas
firstlinetreatmentforneonatalsepsisexceptin
settingswithhighneonatalmortality,whengivenby
trainedhealthworkersincaseswherehospitalcare
isnotachievable.

ComplementaryList
Powderforinjection:250mgpervial(assodiumsalt).
cefotaxime*[c]

ceftazidime

*3rdgenerationcephalosporinofchoiceforusein
hospitalizedneonates.
Powderforinjection:250mgor1g(aspentahydrate)
invial.

19th WHO Model List of Essential Medicines (April 2015)

page - 7

EssentialMedicines
WHOModelList

19thedition

Powderforinjection:250mg(asmonohydrate)+
250mg(assodiumsalt);500mg(asmonohydrate)+
500mg(assodiumsalt)invial.
imipenem*+cilastatin*

*Listedonlyforthetreatmentoflifethreateninghospital
basedinfectionduetosuspectedorprovenmultidrug
resistantinfection.
Meropenemisindicatedforthetreatmentofmeningitis
andislicensedforuseinchildrenovertheageof3
months.

6.2.2 Other antibacterials


Capsule: 250mg;500mg (anhydrous).
azithromycin*

Oralliquid:200mg/5mL.
*Onlylistedforsingledosetreatmentofgenital
Chlamydiatrachomatisandoftrachoma.
Capsule: 250mg.
Oilysuspensionforinjection*:0.5g(assodium
succinate)/mLin2mLampoule.

chloramphenicol

*Onlyforthepresumptivetreatmentofepidemic
meningitisinchildrenolderthan2years.
Oralliquid:150mg(aspalmitate)/5mL.
Powderforinjection:1g(sodiumsuccinate)invial.
Oralliquid: 250mg/5 mL (anhydrous)[c].

ciprofloxacin*

SolutionforIVinfusion:2mg/mL(ashyclate)[c].
Tablet:250mg(ashydrochloride).
*Squareboxappliestoadultsonly.
Solidoraldosageform: 500mg.

clarithromycin*

*Foruseincombinationregimensforeradicationof
H.Pyloriinadults.
Oralliquid:25 mg/5 mL [c];50mg/5mL
(anhydrous)[c].

doxycyclinea

Solidoraldosageform:50mg[c];100mg(as
hyclate).
aUse in children <8 years only for life-threatening
infections when no alternative exists.
Powderforinjection: 500mg(aslactobionate)in
vial.

erythromycin

Powderfororalliquid:125mg/5mL(asstearateor
estolateorethylsuccinate).
Solidoraldosageform:250mg(asstearateor
estolateorethylsuccinate).

19th WHO Model List of Essential Medicines (April 2015)

page - 8

EssentialMedicines
WHOModelList

19thedition

gentamicin

Injection: 10mg;40mg(assulfate)/mLin2 mL
vial.
Injection: 500mgin100 mLvial.

metronidazole

Oralliquid:200mg(asbenzoate)/5mL.
Suppository:500mg;1g.
Tablet:200mgto500mg.

nitrofurantoin
spectinomycin

Oralliquid: 25 mg/5 mL [c].


Tablet:100mg.
Powderforinjection: 2g(ashydrochloride)invial.
Injection:
80mg+16mg/mLin5mLampoule;
80mg+16mg/mLin10mLampoule.

sulfamethoxazole+trimethoprim
Oralliquid:200mg+40mg/5mL.
Tablet:100mg+20mg;400mg+80mg;800mg+
160mg.
Oralliquid: 50mg/5 mL [c].
trimethoprima

Tablet:100mg;200mg.
a

>6 months.

ComplementaryList
Capsule:150mg(ashydrochloride).
clindamycin

Injection:150mg(asphosphate)/mL.
Oralliquid:75mg/5mL(aspalmitate)[c].

vancomycin

Powderforinjection:250mg(ashydrochloride)invial.

6.2.3 Antileprosy medicines


Medicines used in the treatment of leprosy should never be used except in combination. Combination
therapyisessentialtopreventtheemergenceofdrugresistance.Colourcodedblisterpacks(MDTblister
packs) containing standard twomedicine (paucibacillary leprosy) or threemedicine (multibacillary
leprosy)combinationsforadultandchildhoodleprosyshouldbeused.MDTblisterpackscanbesupplied
freeofchargethroughWHO.
clofazimine

Capsule: 50mg;100mg.

dapsone

Tablet: 25mg;50mg;100mg.

rifampicin

Solidoraldosageform: 150mg;300mg.

6.2.4 Antituberculosis medicines


WHOrecommendsandendorsestheuseoffixeddosecombinationsandthedevelopmentofappropriate
newfixeddosecombinations,includingmodifieddosageforms,nonrefrigeratedproductsandpaediatric
dosageformsofassuredpharmaceuticalquality.

19th WHO Model List of Essential Medicines (April 2015)

page - 9

EssentialMedicines
WHOModelList

19thedition

ethambutol

Oralliquid: 25 mg/ mL [c].


Tablet:100mgto400mg(hydrochloride).

ethambutol+isoniazid

Tablet: 400mg+150mg.

ethambutol+isoniazid+pyrazinamide+
rifampicin

Tablet:275mg+75mg+400mg+150mg.

ethambutol+isoniazid+rifampicin

Tablet:275mg+75mg+150mg.
Oralliquid: 50 mg/5 mL [c].

isoniazid

Tablet:100mgto300mg.
Tablet(scored):50mg.
Tablet:

isoniazid+pyrazinamide+rifampicin

75mg+400mg+150mg.
150mg+500mg+150mg(Forintermittentuse
threetimesweekly).
Tablet:

isoniazid+rifampicin

75mg+150mg;150mg+300mg.
60mg+60mg(Forintermittentusethreetimes
weekly).
150mg+150mg(Forintermittentusethreetimes
weekly).
Oralliquid: 30 mg/ mL [c].
Tablet:400mg.

pyrazinamide

Tablet(dispersible):150mg.
Tablet(scored):150mg.
Capsule: 150mg.*

rifabutin

rifampicin

*ForuseonlyinpatientswithHIVreceiving
proteaseinhibitors.
Oralliquid: 20 mg/ mL [c].
Solidoraldosageform:150mg;300mg.
Tablet:150mg

rifapentine*
*FortreatmentoflatentTBinfection(LTBI)only
streptomycin

Powderforinjection: 1g(assulfate)invial.

ComplementaryList
Reservesecondlinedrugsforthetreatmentofmultidrugresistanttuberculosis(MDRTB)should
beusedinspecializedcentresadheringtoWHOstandardsforTBcontrol.
amikacin

Powderforinjection:100mg;500mg;1g(assulfate)
invial.

bedaquiline

Tablet:100mg

19th WHO Model List of Essential Medicines (April 2015)

page - 10

EssentialMedicines
WHOModelList

capreomycin

19thedition

Powderforinjection:1g(assulfate)invial.
Solidoraldosageform:250mg.

cycloserine*
*Terizidonemaybeanalternative
delamanid

Tablet:50mg
Tablet:125mg;250mg.

ethionamide*
*Protionamidemaybeanalternative.
kanamycin

Powderforinjection:1g(assulfate)invial.
Tablet:250mg;500mg;750mg.

levofloxacin*

*Ofloxacinandmoxifloxacinmaybealternativesbased
onavailabilityandprogrammeconsiderations.
Injectionforintravenousadministration:2mg/mL
in300mLbag

linezolid

Powderfororalliquid:100mg/5mL,
Tablet:400mg;600mg
Granules:4ginsachet.

paminosalicylicacid
Tablet:500mg.
streptomycin[c]

Powderforinjection:1g(assulfate)invial.

6.3 Antifungal medicines


amphotericinB

Powderforinjection: 50mginvial(assodium
deoxycholateorliposomalcomplex).
Vaginalcream: 1%;10%.

clotrimazole
Vaginaltablet:100mg;500mg.
Capsule: 50mg.
fluconazole

Injection:2mg/mLinvial.
Oralliquid:50mg/5mL.
Capsule: 250mg.

flucytosine
Infusion:2.5gin250mL.
Oralliquid:125mg/5 mL [c].
griseofulvin
Solidoraldosageform:125mg;250mg.
Lozenge: 100000IU.
nystatin

Oralliquid:50mg/5mL[c];100000IU/mL[c].
Pessary:100000IU.
Tablet:100000IU;500000IU.

ComplementaryList
potassiumiodide

Saturatedsolution.

19th WHO Model List of Essential Medicines (April 2015)

page - 11

EssentialMedicines
WHOModelList

19thedition

6.4 Antiviral medicines


6.4.1 Antiherpes medicines
Oralliquid: 200mg/5 mL [c].
aciclovir

Powderforinjection:250mg(assodiumsalt)in
vial.
Tablet:200mg.

6.4.2 Antiretrovirals
Based on current evidence and experience of use, medicines in the following three classes of
antiretrovirals are included as essential medicines for treatment and prevention of HIV (prevention of
mothertochildtransmissionandpostexposureprophylaxis).WHOemphasizestheimportanceofusing
theseproductsinaccordancewithglobalandnationalguidelines.WHOrecommendsandendorsesthe
use of fixeddose combinations and the development of appropriate new fixeddose combinations,
including modified dosage forms, nonrefrigerated products and paediatric dosage forms of assured
pharmaceuticalquality.
Scored tablets can be used in children and therefore can be considered for inclusion in the listing of
tablets,providedthatadequatequalityproductsareavailable.
6.4.2.1 Nucleoside/Nucleotide reverse transcriptase inhibitors
Oralliquid: 100mg(assulfate)/5mL.
abacavir(ABC)
Tablet:300mg(assulfate).
Oralliquid: 50mg/5 mL.
lamivudine(3TC)
Tablet:150mg.
Capsule: 15 mg;20mg;30mg.
stavudine(d4T)
Powderfororalliquid:5mg/5mL.
tenofovirdisoproxilfumarate(TDF)

Tablet:300mg(tenofovirdisoproxilfumarate
equivalentto245mgtenofovirdisoproxil).
Capsule: 100mg;250mg.
Oralliquid:50mg/5mL.

zidovudine(ZDVorAZT)

SolutionforIVinfusioninjection:10mg/mLin
20mLvial.
Tablet:300mg.

6.4.2.2 Non-nucleoside reverse transcriptase inhibitors


Capsule: 50mg;100mg;200mg.
efavirenz(EFVorEFZ)a

Tablet:200mg(scored);600mg.
a

>3 years or >10 kg weight.

Oralliquid: 50mg/5 mL.


nevirapine(NVP)
Tablet:50mg(dispersible);200mg.
6.4.2.3 Protease inhibitors
19th WHO Model List of Essential Medicines (April 2015)

page - 12

EssentialMedicines
WHOModelList

19thedition

Selection of protease inhibitor(s) from the Model List will need to be determined by each country after
consideration of international and national treatment guidelines and experience. Ritonavir is
recommendedforuseincombinationasapharmacologicalbooster,andnotasanantiretroviralinitsown
right.Allotherproteaseinhibitorsshouldbeusedinboostedforms(e.g.withritonavir).

atazanavira

Solidoraldosageform:100mg;150mg;300mg (as
sulfate).
a

darunavir a

>25 kg.

Tablet:75mg;400mg;600mg;800mg
a

>3 years

Oralliquid: 400mg+100mg/5mL.
lopinavir+ritonavir(LPV/r)

Tablet(heatstable):100mg+25mg;
200mg+50mg.
Oralliquid: 400mg/5 mL.

ritonavir
Tablet(heatstable):25mg;100mg.

saquinavir(SQV)a

Solidoraldosageform: 200mg;500mg(as
mesilate).
a

>25 kg.

FIXED-DOSE COMBINATIONS
abacavir+lamivudine

efavirenz+emtricitabine+tenofovir

Tablet(dispersible,scored):60mg(assulfate)+30
mg
Tablet:600mg+200mg+300mg(disoproxil
fumarateequivalentto245mgtenofovirdisoproxil).

emtricitabine+tenofovir

Tablet: 200mg+300mg (disoproxilfumarate


equivalentto245mgtenofovirdisoproxil).

Tablet: 150mg+200mg+30mg.

lamivudine+nevirapine+stavudine

lamivudine+nevirapine+zidovudine
lamivudine+zidovudine

Tablet(dispersible):30mg+50mg+6mg[c].

Tablet: 30mg+50mg+60mg[c];150mg+200 mg
+300mg.
Tablet: 30mg+60mg[c];150mg+300mg.

6.4.3 Other antivirals


Capsule:30mg;45mg;75mg(asphosphate).
Oralpowder:12mg/mL.
oseltamivir*

*potentiallysevereorcomplicatedillnessdueto
confirmedorsuspectedinfluenzavirusinfectionin
accordancewithWHOtreatmentguidelines.

19th WHO Model List of Essential Medicines (April 2015)

page - 13

EssentialMedicines
WHOModelList

19thedition

Injectionforintravenousadministration:800mg
and1gin10mLphosphatebuffersolution.
ribavirin*

Solidoraldosageform:200mg;400mg;600mg.
*Forthetreatmentofviralhaemorrhagicfevers

valganciclovir*

Tablet:450mg.

*Forthetreatmentofcytomegalovirusretinitis
(CMV).

6.4.4 Antihepatitis medicines


6.4.4.1 Medicines for hepatitis B
6.4.4.1.1 Nucleoside/Nucleotide reverse transcriptase inhibitors
Oralliquid:0.05mg/mL
entecavir
tenofovirdisoproxilfumarate(TDF)

Tablet:0.5mg;1mg
Tablet:300mg(tenofovirdisoproxilfumarate
equivalentto245mgtenofovirdisoproxil).

6.4.4.2 Medicines for hepatitis C


Basedoncurrentevidence,medicinesinthefollowingclassesofdirectactingantiviralmedicinesare
includedasessentialmedicinesfortreatmentofhepatitisCvirusinfection.WHOguidelinesrecommend
specificcombinationtherapyutilisingmedicinesfromdifferentclasses.[\url]
6.4.4.2.1 Nucleotide polymerase inhibitors
sofosbuvir

Tablet:400mg

6.4.4.2.2 Protease inhibitors


simeprevir

Capsule150mg

6.4.4.2.3 NS5A inhibitors


daclatasvir

Tablet:30mg(ashydrochloride)

6.4.4.2.4 Non-nucleoside polymerase inhibitors


dasabuvir

Tablet: 250mg

6.4.4.2.5 Other antivirals


Injectionforintravenousadministration:800mg
and1gin10mLphosphatebuffersolution.
ribavirin*

Solidoraldosageform:200mg;400mg;600mg.
*ForthetreatmentofhepatitisC,incombination
withpeginterferonand/ordirectactingantiviral
medicines

ComplementaryList

19th WHO Model List of Essential Medicines (April 2015)

page - 14

EssentialMedicines
WHOModelList

19thedition

Vialorprefilledsyringe:
180micrograms(peginterferonalfa2a),
pegylatedinterferonalfa(2aor2b)*
80microgram,100microgram(peginterferonalfa2b).
*Tobeusedincombinationwithribavirin.
FIXED-DOSE COMBINATIONS
Alternative combinations of DAAs from different pharmacological classes are possible
ledipasvir+sofosbuvir

Tablet:90mg+400mg.

ombitasvir+paritaprevir+ritonavir

Tablet:12.5mg+75mg+50mg

6.5 Antiprotozoal medicines


6.5.1 Antiamoebic and antigiardiasis medicines
diloxanidea

Tablet: 500mg(furoate).
a

>25 kg.

Injection: 500mgin100 mLvial.


metronidazole

Oralliquid:200mg(asbenzoate)/5mL.
Tablet:200mgto500mg.

6.5.2 Antileishmaniasis medicines


amphotericinB

Powderforinjection: 50mginvial(assodium
deoxycholateorliposomalcomplex).

miltefosine

Solidoraldosageform:10mg;50mg.

paromomycin

Solutionforintramuscularinjection:750mgof
paromomycinbase(asthesulfate).
Injection: 100mg/ mL,1vial=30mLor30%,
equivalenttoapproximately8.1%antimony
(pentavalent)in5mLampoule.

sodiumstibogluconateormeglumineantimoniate
6.5.3 Antimalarial medicines
6.5.3.1 For curative treatment

Medicines for the treatment of P. falciparum malaria cases should be used in combination. The list
currentlyrecommendscombinationsaccordingtotreatmentguidelines.WHOrecognizesthatnotallof
the fixed dose combinations (FDCs) in the WHO treatment guidelines exist, and encourages their
development and rigorous testing. WHO also encourages development and testing of rectal dosage
formulations.
Tablet: 153mg or200mg(ashydrochloride).
amodiaquine*
*Tobeusedincombinationwithartesunate50mg.
Oilyinjection: 80mg/ mL in1mLampoule.
artemether*
*Foruseinthemanagementofseveremalaria.

19th WHO Model List of Essential Medicines (April 2015)

page - 15

EssentialMedicines
WHOModelList

19thedition

Tablet: 20mg+120mg.
artemether+lumefantrine*

Tablet(dispersible):20mg+120mg[c].
*Notrecommendedinthefirsttrimesterof
pregnancyorinchildrenbelow5kg.
Injection: ampoules,containing60mganhydrous
artesunicacidwithaseparateampouleof5%
sodiumbicarbonatesolution.
Foruseinthemanagementofseveremalaria.

artesunate*

Rectaldosageform:50mg[c];200mgcapsules(for
prereferraltreatmentofseveremalariaonly;
patientsshouldbetakentoanappropriatehealth
facilityforfollowupcare)[c].
Tablet:50mg.
*Tobeusedincombinationwitheither
amodiaquine,mefloquineorsulfadoxine+
pyrimethamine.
Tablet: 25 mg+ 67.5 mg;50 mg+135mg;100 mg+
270mg.

artesunate+amodiaquine*

artesunate+mefloquine

*Othercombinationsthatdeliverthetargetdoses
requiredsuchas153mgor200mg(as
hydrochloride)with50mgartesunatecanbe
alternatives.
Tablet: 25 mg+ 55mg;100 mg+220mg.
Oralliquid: 50mg(asphosphateorsulfate)/5 mL.

chloroquine*

Tablet:100mg;150mg(asphosphateorsulfate).
*ForuseonlyforthetreatmentofP.vivaxinfection.
Capsule: 100mg(ashydrochlorideorhyclate).

doxycycline*

Tablet(dispersible):100mg(asmonohydrate).
*Foruseonlyincombinationwithquinine.
Tablet: 250mg(ashydrochloride).

mefloquine*
*Tobeusedincombinationwithartesunate50mg.
Tablet: 7.5mg;15 mg(asdiphosphate).
primaquine*

*OnlyforusetoachieveradicalcureofP.vivaxand
P.ovaleinfections,givenfor14days.

19th WHO Model List of Essential Medicines (April 2015)

page - 16

EssentialMedicines
WHOModelList

19thedition

Injection: 300mgquininehydrochloride/mL in2


mLampoule.
quinine*

Tablet:300mg(quininesulfate)or300mg(quinine
bisulfate).
*Foruseonlyinthemanagementofseveremalaria,
andshouldbeusedincombinationwith
doxycycline.
Tablet: 500mg+25mg.

sulfadoxine+pyrimethamine*
*Onlyincombinationwithartesunate50mg.
6.5.3.2 For prophylaxis
Oralliquid: 50mg(asphosphateorsulfate)/5 mL.
chloroquine*

Tablet:150mg(asphosphateorsulfate).
*ForuseonlyincentralAmericanregions,for
P.vivaxinfections.

doxycyclinea

Solidoral dosageform: 100mg(ashydrochloride or


hyclate).
a

>8 years.

Tablet: 250mg(ashydrochloride).
mefloquinea

>5 kg or >3 months.

Tablet: 100mg(ashydrochloride).
proguanil*
*Foruseonlyincombinationwithchloroquine.
6.5.4 Antipneumocystosis and antitoxoplasmosis medicines
pyrimethamine

Tablet: 25mg.

sulfadiazine

Tablet:500mg.
Injection:

sulfamethoxazole+trimethoprim

80mg+16mg/mLin5mLampoule;
80mg+16mg/mLin10mLampoule.
Oralliquid:200mg+40mg/5mL[c].
Tablet:100mg+20mg;400mg+80mg[c].

ComplementaryList
pentamidine

Tablet:200mg;300mg(asisethionate).

6.5.5 Antitrypanosomal medicines


6.5.5.1 African trypanosomiasis
Medicinesforthetreatmentof1ststageAfricantrypanosomiasis
Powderforinjection:200mg(asisetionate)invial.
pentamidine*

*TobeusedforthetreatmentofTrypanosomabrucei
gambienseinfection.

19th WHO Model List of Essential Medicines (April 2015)

page - 17

EssentialMedicines
WHOModelList

19thedition

Powderforinjection: 1ginvial.
suraminsodium*

*Tobeusedforthetreatmentoftheinitialphaseof
Trypanosomabruceirhodesienseinfection.

Medicinesforthetreatmentof2ndstageAfricantrypanosomiasis

eflornithine*

melarsoprol

nifurtimox*

Injection:200mg(hydrochloride)/mLin100 mL
bottle.
*TobeusedforthetreatmentofTrypanosomabrucei
gambienseinfection.
Injection: 3.6%solution,5 mLampoule(180mgof
active
compound).
Tablet: 120mg.
*Onlytobeusedincombinationwitheflornithine,
forthetreatmentofTrypanosomabruceigambiense
infection.

ComplementaryList[c]
melarsoprol

Injection:3.6%solutionin5mLampoule(180mgof
activecompound).

6.5.5.2 American trypanosomiasis


Tablet: 12.5mg [c];100mg.
benznidazole
Tablet(scored):50mg.
nifurtimox

Tablet: 30mg;120mg;250mg.

7. ANTIMIGRAINE MEDICINES
7.1 For treatment of acute attack
acetylsalicylicacid

Tablet: 300mgto500mg.

ibuprofen[c]

Tablet:200mg;400mg.

paracetamol

Oralliquid: 125mg/5 mL [c].


Tablet:300mgto500mg.

7.2 For prophylaxis


propranolol

Tablet: 20mg;40mg(hydrochloride).

8. ANTINEOPLASTICS AND IMMUNOSUPPRESSIVES


Medicineslistedbelowshouldbeusedaccordingtoprotocolsfortreatmentofthediseases.
8.1 Immunosuppressive medicines
ComplementaryList
Powderforinjection:100mg(assodiumsalt)invial.
azathioprine
Tablet(scored):50mg.

19th WHO Model List of Essential Medicines (April 2015)

page - 18

EssentialMedicines
WHOModelList

19thedition

Capsule:25mg.
ciclosporin

Concentrateforinjection:50mg/mLin1mLampoule
fororgantransplantation.

8.2 Cytotoxic and adjuvant medicines


ComplementaryList
alltransretinoidacid(ATRA)
allopurinol[c]

Capsule:10mg.
acutepromyelocyticleukemia.
Tablet:100mg;300mg.
Powderforinjection:10000IUinvial.

asparaginase

acutelymphoblasticleukemia.
Injection:45mg/0.5mL;180mg/2mL.

bendamustine

chroniclymphocyticleukemia
follicularlymphoma
Powderforinjection:15mg(assulfate)invial.

bleomycin

Hodgkinlymphoma
Kaposisarcoma
ovariangermcelltumour
testiculargermcelltumour

Injection:3mg/mLin10mLampoule.
Tablet:15mg.

calciumfolinate

earlystagecoloncancer
earlystagerectalcancer
gestationaltrophoblasticneoplasia
metastaticcolorectalcancer
osteosarcoma
Burkittlymphoma

Tablet:150mg;500mg.

capecitabine

earlystagecoloncancer
earlystagerectalcancer
metastaticbreastcancer
metastaticcolorectalcancer

Injection:50mg/5mL;150mg/15mL;450mg/45mL;
600mg/60mL.

carboplatin

19th WHO Model List of Essential Medicines (April 2015)

earlystagebreastcancer
epithelialovariancancer
nasopharyngealcancer
nonsmallcelllungcancer
osteosarcoma
retinoblastoma

page - 19

EssentialMedicines
WHOModelList

19thedition

Tablet:2mg.
chlorambucil

chroniclymphocyticleukemia.
Injection:50mg/50mL;100mg/100mL.

cisplatin

cervicalcancer(asaradiosensitizer)
headandneckcancer(asaradiosensitizer)
nasopharyngealcancer(asaradiosensitizer)
nonsmallcelllungcancer
osteosarcoma
ovariangermcelltumour
testiculargermcelltumour

Powderforinjection:500mginvial.
Tablet:25mg.

cyclophosphamide

chroniclymphocyticleukemia
diffuselargeBcelllymphoma
earlystagebreastcancer
gestationaltrophoblasticneoplasia
Hodgkinlymphoma
follicularlymphoma
rhabdomyosarcoma
Ewingsarcoma
acutelymphoblasticleukemia
Burkittlymphoma
metastaticbreastcancer.

Powderforinjection:100mginvial.

cytarabine

acutemyelogenousleukemia
acutelymphoblasticleukemia
acutepromyelocyticleukemia
Burkittlymphoma.

Powderforinjection:100mginvial.
dacarbazine

Hodgkinlymphoma
Powderforinjection:500microgramsinvial.

dactinomycin

gestationaltrophoblasticneoplasia
rhabdomyosarcoma
Wilmstumour

Powderforinjection:50mg(hydrochloride)invial.
acutemyelogenousleukemia
acutepromyelocyticleukemia

daunorubicin

Injection:20mg/mL;40mg/mL.
docetaxel

19th WHO Model List of Essential Medicines (April 2015)

earlystagebreastcancer
metastaticbreastcancer
metastaticprostatecancer
page - 20

EssentialMedicines
WHOModelList

19thedition

Powderforinjection:10mg;50mg(hydrochloride)in
vial.

doxorubicin

diffuselargeBcelllymphoma
earlystagebreastcancer
Hodgkinlymphoma
Kaposisarcoma
follicularlymphoma
metastaticbreastcancer
osteosarcoma
Ewingsarcoma
acutelymphoblasticleukemia
Wilmstumour
Burkittlymphoma

Capsule:100mg.
Injection:20mg/mLin5mLampoule.

etoposide

testiculargermcelltumour
gestationaltrophoblasticneoplasia
Hodgkinlymphoma
nonsmallcelllungcancer
ovariangermcelltumour
retinoblastoma
Ewingsarcoma
acutelymphoblasticleukemia
Burkittlymphoma

Powderforinjection:50mg(phosphate)invial.
fludarabine

Tablet:10mg
chroniclymphocyticleukemia.
Injection:50mg/mLin5mLampoule.

fluorouracil

19th WHO Model List of Essential Medicines (April 2015)

earlystagebreastcancer
earlystagecoloncancer
earlystagerectalcancer
metastaticcolorectalcancer
nasopharyngealcancer.

page - 21

EssentialMedicines
WHOModelList

19thedition

Injection:120micrograms/0.2mL;300micrograms/0.5
mL;480micrograms/0.8mLinprefilledsyringe300
micrograms/mLin1mLvial,480mg/1.6mLin1.6mL
vial.
Asprimaryprophylaxisinpatientsathighriskfor
developingfebrileneutropeniaassociatedwith
myelotoxicchemotherapy.
Assecondaryprophylaxisforpatientswhohave
experiencedneutropeniafollowingpriormyelotoxic
chemotherapy
tofacilitateadministrationofdosedense
chemotherapyregimens

filgrastim

Powderforinjection:200mginvial,1ginvial.
gemcitabine

hydroxycarbamide

epithelialovariancancer
nonsmallcelllungcancer
Solidoraldosageform:200mg;250mg;300mg;400
mg;500mg;1g.
chronicmyeloidleukemia.
Powderforinjection:500mgvial;1gvial;2gvial.

ifosfamide

testiculargermcelltumour
ovariangermcelltumour
osteosarcoma
rhabdomyosarcoma
Ewingsarcoma

Tablet:100mg;400mg.
imatinib

irinotecan

chronicmyeloidleukemia
gastrointestinalstromaltumour
Injection:40mg/2mLin2mLvial;100mg/5mLin5
mLvial;500mg/25mLin25mLvial.
metastaticcolorectalcancer.
Tablet:50mg.

mercaptopurine

acutelymphoblasticleukemia
acutepromyelocyticleukemia.
Injection:100mg/mLin4mLand10mLampoules.
Tablet:400mg;600mg.

mesna

19th WHO Model List of Essential Medicines (April 2015)

testiculargermcelltumour
ovariangermcelltumour
osteosarcoma
rhabdomyosarcoma
Ewingsarcoma.

page - 22

EssentialMedicines
WHOModelList

19thedition

Powderforinjection:50mg(assodiumsalt)invial.
Tablet:2.5mg(assodiumsalt).

methotrexate

earlystagebreastcancer
gestationaltrophoblasticneoplasia
osteosarcoma
acutelymphoblasticleukemia
acutepromyelocyticleukemia

Injection:50mg/10mLin10mLvial;100mg/20mLin
20mLvial;200mg/40mLin40mLvial.
oxaliplatin

Powderforinjection:50mg,100mginvial.
earlystagecoloncancer
metastaticcolorectalcancer
Powderforinjection:6mg/mL.

paclitaxel

procarbazine

epithelialovariancancer
earlystagebreastcancer
metastaticbreastcancer
Kaposisarcoma
nasopharyngealcancer
nonsmallcelllungcancer
ovariangermcelltumour

Capsule:50mg(ashydrochloride).
Injection:100mg/10mLin10mLvial;500mg/50mL
in50mLvial.

rituximab

tioguanine[c]

diffuselargeBcelllymphoma
chroniclymphocyticleukemia
follicularlymphoma.

Solidoraldosageform:40mg.

acutelymphoblasticleukemia.

Doseform:
trastuzumab

earlystageHER2positivebreastcancer
metastaticHER2positivebreastcancer.
Powderforinjection:10mg(sulfate)invial.

vinblastine

19th WHO Model List of Essential Medicines (April 2015)

Hodgkinlymphoma
Kaposisarcoma.
Testiculargermcelltumour
Ovariangermcelltumour

page - 23

EssentialMedicines
WHOModelList

19thedition

Powderforinjection:1mg;5mg(sulfate)invial.

vincristine

diffuselargeBcelllymphoma
gestationaltrophoblasticneoplasia
Hodgkinlymphoma
Kaposisarcoma
follicularlymphoma
retinoblastoma
rhabdomyosarcoma
Ewingsarcoma
acutelymphoblasticleukemia
Wilmstumour
Burkittlymphoma.

Injection:10mg/mLin1mLvial;50mg/5mLin5
mLvial.
vinorelbine

nonsmallcelllungcancer
metastaticbreastcancer

8.3 Hormones and antihormones


ComplementaryList
Tablet:1mg.
anastrozole

bicalutamide

earlystagebreastcancer
metastaticbreastcancer.
Tablet:50mg.
metastaticprostatecancer.
Injection:4mg/mLin1mLampoule(asdisodium
phosphatesalt).

dexamethasone

Oralliquid:2mg/5mL[c].
acutelymphoblasticleukemia.
Doseform

leuprorelin

hydrocortisone

earlystagebreastcancer
metastaticprostatecancer
Powderforinjection:100mg(assodiumsuccinate)in
vial.
acutelymphoblasticleukemia.

methylprednisolone[c]

Injection:40mg/mL(assodiumsuccinate)in1mL
singledosevialand
5mLmultidosevials;80mg/mL(assodiumsuccinate)
in1mLsingledosevial.

19th WHO Model List of Essential Medicines (April 2015)

acutelymphoblasticleukamia.

page - 24

EssentialMedicines
WHOModelList

19thedition

Oralliquid:5mg/mL[c].
Tablet:5mg;25mg.

prednisolone

chroniclymphocyticleukemia
diffuselargeBcelllymphoma
Hodgkinlymphoma
follicularlymphoma
acutelymphoblasticleukemia
Burkittlymphoma

Tablet:10mg;20mg(ascitrate).
tamoxifen

earlystagebreastcancer
metastaticbreastcancer

9. ANTIPARKINSONISM MEDICINES
biperiden

Injection: 5mg(lactate)in1mLampoule.
Tablet:2mg(hydrochloride).

levodopa+carbidopa

Tablet: 100mg+10mg;100mg+25mg;250mg+
25mg

10. MEDICINES AFFECTING THE BLOOD


10.1 Antianaemia medicines

ferroussalt

Oralliquid: equivalentto25mgiron(assulfate)/
mL.
Tablet:equivalentto60mgiron.

ferroussalt+folicacid

Tablet: equivalentto60mgiron+400micrograms
folicacid
(nutritionalsupplementforuseduringpregnancy).
Tablet: 400micrograms*;1mg;5mg.

folicacid

hydroxocobalamin

*periconceptualuseforpreventionoffirst
occurrenceofneuraltubedefects
Injection: 1mg (asacetate,ashydrochloride oras
sulfate)in1mLampoule.

10.2 Medicines affecting coagulation


Injection:ampouleorprefilledsyringe

enoxaparin*

20mg/0.2mL;40mg/0.4mL;60mg/0.6mL;80
mg/0.8mL;100mg/1mL;120mg/0.8mL;150mg/1
mL
*Alternativesarelimitedtonadroparinand
dalteparin

heparinsodium

Injection: 1000IU/ mL;5000IU/mL;20000IU/ mL


in1mLampoule.

19th WHO Model List of Essential Medicines (April 2015)

page - 25

EssentialMedicines
WHOModelList

19thedition

phytomenadione

Injection: 1mg/ mL [c]; 10mg/mLin5mL


ampoule.
Tablet:10mg.

protaminesulfate

Injection: 10mg/ mL in5 mLampoule.

tranexamicacid

Injection: 100 mg/ mL in10mLampoule.

warfarin

Tablet: 1mg;2mg;5mg(sodiumsalt).

ComplementaryList[c]

desmopressin

Injection:4micrograms/mL(asacetate)in1mL
ampoule.
Nasalspray:10micrograms(asacetate)perdose

heparinsodium

Injection:1000IU/mL;5000IU/mLin1mLampoule.

protaminesulfate

Injection:10mg/mLin5mLampoule.

warfarin

Tablet:0.5mg;1mg;2mg;5mg(sodiumsalt).

10.3 Other medicines for haemoglobinopathies


ComplementaryList
deferoxamine*

Powderforinjection:500mg(mesilate)invial.
*Deferasiroxoralformmaybeanalternative,depending
oncostandavailability.

hydroxycarbamide

Solidoraldosageform:200mg;500mg;1g.

11. BLOOD PRODUCTS OF HUMAN ORIGIN AND PLASMA SUBSTITUTES


11.1 Blood and blood components
InaccordancewiththeWorldHealthAssemblyresolutionWHA63.12,WHOrecognizesthatachieving
selfsufficiency,unlessspecialcircumstancesprecludeit,inthesupplyofsafebloodcomponentsbasedon
voluntary,nonremuneratedblooddonation,andthesecurityofthatsupplyareimportantnationalgoals
topreventbloodshortagesandmeetthetransfusionrequirementsofthepatientpopulation.All
preparationsshouldcomplywiththeWHOrequirements.
freshfrozenplasma

platelets

redbloodcells

wholeblood

11.2 Plasma-derived medicines


AllhumanplasmaderivedmedicinesshouldcomplywiththeWHOrequirements.
11.2.1 Human immunoglobulins
antiDimmunoglobulin

Injection: 250microgramsinsingledosevial.

Antirabiesimmunoglobulin

Injection: 150IU/ mL invial.

Antitetanusimmunoglobulin

Injection: 500IUinvial.

ComplementaryList

19th WHO Model List of Essential Medicines (April 2015)

page - 26

EssentialMedicines
WHOModelList

19thedition

Intramuscularadministration:16%protein
solution.*
Intravenousadministration:5%;10%protein
solution.**
normalimmunoglobulin

Subcutaneousadministration:15%;16%protein
solution.*
*Indicatedforprimaryimmunedeficiency.
**Indicatedforprimaryimmunedeficiencyand
Kawasakidisease.

11.2.2 Blood coagulation factors


ComplementaryList
coagulationfactorVIII

Powderforinjection:500IU/vial.

coagulationfactorIX

Powderforinjection:500IU/vial,1000IU/vial.

11.3 Plasma substitutes


Injectablesolution:6%.
dextran70*

*Polygeline,injectablesolution,3.5%isconsidered
asequivalent.

12. CARDIOVASCULAR MEDICINES


12.1 Antianginal medicines
Tablet: 1.25 mg;5mg.
bisoprolol*

*includesmetoprololandcarvedilolas
alternatives.

glyceryltrinitrate

Tablet(sublingual): 500micrograms.

isosorbidedinitrate

Tablet(sublingual): 5mg.

verapamil

Tablet:40mg;80mg(hydrochloride).

12.2 Antiarrhythmic medicines


Tablet: 1.25 mg;5mg.
bisoprolol*

*includesmetoprololandcarvedilolas
alternatives.
Injection: 250micrograms/ mLin2mLampoule.

digoxin

Oralliquid:50micrograms/mL.
Tablet:62.5micrograms;250micrograms.

epinephrine(adrenaline)

Injection:100micrograms/ mL(asacidtartrate or
hydrochloride)in10mLampoule.

lidocaine

Injection: 20mg(hydrochloride)/mLin5mL
ampoule.

19th WHO Model List of Essential Medicines (April 2015)

page - 27

EssentialMedicines
WHOModelList

19thedition

verapamil

Injection: 2.5mg(hydrochloride)/mLin2mL
ampoule.
Tablet:40mg;80mg(hydrochloride).

ComplementaryList

Injection:50mg/mLin3mLampoule(hydrochloride).

amiodarone
Tablet:100mg;200mg;400mg(hydrochloride).
12.3 Antihypertensive medicines
amlodipine

Tablet: 5 mg (asmaleate,mesylateorbesylate).
Tablet:1.25 mg;5mg.

bisoprolol*

enalapril

*includesatenolol,metoprololandcarvedilolas
alternatives.Atenololshouldnotbeusedasafirst
lineagentinuncomplicatedhypertensionin
patients>60years
Tablet: 2.5mg;5mg (ashydrogenmaleate).
Powderforinjection: 20mg(hydrochloride)in
ampoule.
Tablet:25mg;50mg(hydrochloride).

hydralazine*

hydrochlorothiazide

*Hydralazineislistedforuseonlyintheacute
managementofseverepregnancyinduced
hypertension.Itsuseinthetreatmentofessential
hypertensionisnotrecommendedinviewofthe
evidenceofgreaterefficacyandsafetyofother
medicines.
Oralliquid:50mg/5 mL.
Solidoraldosageform:12.5mg;25mg.
Tablet:250mg.

methyldopa*

*Methyldopaislistedforuseonlyinthe
managementofpregnancyinducedhypertension.Its
useinthetreatmentofessentialhypertensionisnot
recommendedinviewoftheevidenceofgreater
efficacyandsafetyofothermedicines.

ComplementaryList
sodiumnitroprusside

Powderforinfusion:50mginampoule.

12.4 Medicines used in heart failure


Tablet:1.25 mg;5mg.
bisoprolol*

*includesmetoprololandcarvedilolas
alternatives.

19th WHO Model List of Essential Medicines (April 2015)

page - 28

EssentialMedicines
WHOModelList

19thedition

Injection: 250micrograms/ mLin2mLampoule.


digoxin

Oralliquid:50micrograms/mL.
Tablet:62.5micrograms;250micrograms.

enalapril

Tablet: 2.5mg;5mg (ashydrogenmaleate).


Injection: 10mg/ mL in2 mLampoule.

furosemide

Oralliquid:20mg/5mL[c].
Tablet:40mg.

hydrochlorothiazide

Oralliquid:50mg/5 mL.
Solidoraldosageform:25mg.

spironolactone

Tablet: 25mg.

ComplementaryList
dopamine

Injection:40mg/mL(hydrochloride)in5mLvial.

12.5 Antithrombotic medicines


12.5.1 Anti-platelet medicines
acetylsalicylicacid

Tablet: 100mg.

clopidogrel

Tablet:75mg;300mg

12.5.2 Thrombolytic medicines


ComplementaryList
streptokinase

Powderforinjection:1.5millionIUinvial.

12.6 Lipid-lowering agents


simvastatin*

Tablet: 5mg;10mg;20mg;40mg.
*Foruseinhighriskpatients.

13. DERMATOLOGICAL MEDICINES (topical)


13.1 Antifungal medicines
miconazole

Creamorointment:2%(nitrate).

seleniumsulfide

Detergentbasedsuspension:2%.

sodiumthiosulfate

Solution: 15%.

terbinafine

Cream: 1% orOintment: 1%terbinafine


hydrochloride.

13.2 Anti-infective medicines


Cream(asmupirocincalcium):2%.
mupirocin
Ointment:2%.
potassiumpermanganate

Aqueoussolution: 1:10000.

19th WHO Model List of Essential Medicines (April 2015)

page - 29

EssentialMedicines
WHOModelList

19thedition

Cream:1%.
silversulfadiazinea

>2 months.

13.3 Anti-inflammatory and antipruritic medicines


betamethasonea

Creamorointment:0.1%(asvalerate).
a

Hydrocortisone preferred in neonates.

calamine

Lotion.

hydrocortisone

Creamorointment:1%(acetate).

13.4 Medicines affecting skin differentiation and proliferation


benzoylperoxide

Creamorlotion: 5%.

coaltar

Solution: 5%.

fluorouracil

Ointment: 5%.

podophyllumresin

Solution: 10%to25%.

salicylicacid

Solution: 5%.

urea

Creamorointment: 5%;10%.

13.5 Scabicides and pediculicides


benzylbenzoatea

Lotion: 25%.
a

>2 years.

Cream: 5%.
permethrin
Lotion:1%.
14. DIAGNOSTIC AGENTS
14.1 Ophthalmic medicines
fluorescein

Eyedrops: 1%(sodiumsalt).

tropicamide

Eyedrops: 0.5%.

14.2 Radiocontrast media


amidotrizoate

Injection: 140mgto420mgiodine(assodium or
megluminesalt)/mLin20mLampoule.

bariumsulfate

Aqueoussuspension.

iohexol

Injection: 140mgto350mgiodine/mLin5 mL;10


mL;20mLampoules.

ComplementaryList
bariumsulfate[c]

Aqueoussuspension.

meglumineiotroxate

Solution:5gto8giodinein100mLto250mL.

15. DISINFECTANTS AND ANTISEPTICS


15.1 Antiseptics

19th WHO Model List of Essential Medicines (April 2015)

page - 30

EssentialMedicines
WHOModelList

19thedition

chlorhexidine

Solution:5%(digluconate).

ethanol

Solution: 70%(denatured).

povidoneiodine

Solution: 10% (equivalentto1%availableiodine).

15.2 Disinfectants
Solutioncontainingethanol80%volume/volume
alcoholbasedhandrub

Solutioncontainingisopropylalcohol75%
volume/volume

chlorinebasecompound

Powder: (0.1%availablechlorine)forsolution.

chloroxylenol

Solution: 4.8%.

glutaral

Solution: 2%.

16. DIURETICS
amiloride

Tablet: 5mg(hydrochloride).
Injection: 10mg/ mL in2 mLampoule.

furosemide

Oralliquid:20mg/5mL[c].
Tablet:10mg[c];20mg[c];40mg.

hydrochlorothiazide

Solidoraldosageform:25mg.

mannitol

Injectablesolution: 10%;20%.

spironolactone

Tablet: 25mg.

ComplementaryList[c]
hydrochlorothiazide

Tablet(scored):25mg.

mannitol

Injectablesolution:10%;20%.

spironolactone

Oralliquid:5mg/5mL;10mg/5mL;25mg/5mL.
Tablet:25mg.

17. GASTROINTESTINAL MEDICINES


ComplementaryList[c]
pancreaticenzymes

Ageappropriateformulationsanddosesincludinglipase,
proteaseandamylase.

17.1 Antiulcer medicines


Powderforinjection:40mginvial
omeprazole

Powderfororalliquid:20mg;40mgsachets.
Solidoraldosageform:10mg;20mg;40mg.

19th WHO Model List of Essential Medicines (April 2015)

page - 31

EssentialMedicines
WHOModelList

19thedition

Injection: 25 mg/ mL (ashydrochloride)in2 mL


ampoule.
ranitidine

Oralliquid:75mg/5mL(ashydrochloride).
Tablet:150mg(ashydrochloride).

17.2 Antiemetic medicines


Injection: 4mg/ mL in1 mLampoule(asdisodium
phosphatesalt).
dexamethasone

Oralliquid:0.5mg/5mL;2mg/5mL.
Solidoraldosageform:0.5mg;0.75mg;1.5mg;
4mg.
Injection: 5mg(hydrochloride)/mLin2mL
ampoule.

metoclopramidea

Oralliquid:5mg/5mL[c].
Tablet:10mg(hydrochloride).
a

Not in neonates.

Injection:2mgbase/ mL in2mLampoule(as
hydrochloride).
ondansetrona

Oralliquid:4mgbase/5mL.
Solidoraldosageform:Eq4mgbase;Eq8mgbase;
Eq24mgbase.
a

>1 month.

17.3 Anti-inflammatory medicines


Retentionenema.
sulfasalazine

Suppository:500mg.
Tablet:500mg.

ComplementaryList
Retentionenema.
hydrocortisone

Suppository:25mg(acetate).
(theonlyappliestohydrocortisoneretention
enema).

17.4 Laxatives
senna

Tablet: 7.5mg(sennosides)(ortraditionaldosage
forms).

17.5 Medicines used in diarrhoea


17.5.1 Oral rehydration

19th WHO Model List of Essential Medicines (April 2015)

page - 32

EssentialMedicines
WHOModelList

19thedition

oralrehydrationsalts

Powderfordilution in200 mL;500mL;1L.

glucose:

75mEq
sodium:

75mEqormmol/L
chloride:

65mEqormmol/L
potassium:

20mEqormmol/L
citrate:

10mmol/L
osmolarity:

245mOsm/L
glucose:

13.5g/L
sodiumchloride:

2.6g/L
potassiumchloride:

1.5g/L
trisodiumcitratedihydrate*:
2.9g/L
*trisodiumcitratedihydratemaybereplacedby
sodiumhydrogencarbonate(sodiumbicarbonate)
2.5g/L.However,asthestabilityofthislatter
formulationisverypoorundertropicalconditions,it
isrecommendedonlywhenmanufacturedfor
immediateuse.

17.5.2 Medicines for diarrhoea


Solidoraldosageform: 20mg.
zincsulfate*

*Inacutediarrhoeazincsulfateshouldbeusedasan
adjuncttooralrehydrationsalts.

18. HORMONES, OTHER ENDOCRINE MEDICINES AND CONTRACEPTIVES


18.1 Adrenal hormones and synthetic substitutes
fludrocortisone

Tablet:100micrograms(acetate).

hydrocortisone

Tablet:5mg;10mg;20mg.

18.2 Androgens
ComplementaryList
testosterone

Injection:200mg(enanthate)in1mLampoule.

18.3 Contraceptives
18.3.1 Oral hormonal contraceptives
ethinylestradiol+levonorgestrel

Tablet: 30micrograms+150micrograms.

ethinylestradiol+norethisterone

Tablet: 35micrograms+1mg.

levonorgestrel

Tablet: 30micrograms;750micrograms(packof
two);1.5mg.

18.3.2 Injectable hormonal contraceptives


estradiolcypionate+medroxyprogesteroneacetate Injection:5mg+25mg.
medroxyprogesteroneacetate

Depotinjection: 150mg/ mLin1mLvial.

norethisteroneenantate

Oilysolution: 200mg/ mL in1mLampoule.

18.3.3 Intrauterine devices


19th WHO Model List of Essential Medicines (April 2015)

page - 33

EssentialMedicines
WHOModelList

19thedition

coppercontainingdevice
levonorgestrelreleasingintrauterinesystem

Intrauterinesystemwithreservoircontaining52mg
oflevonorestrel

18.3.4 Barrier methods


condoms
diaphragms
18.3.5 Implantable contraceptives
etonogestrelreleasingimplant

Singlerodetonogestrelreleasingimplant,
containing68mgofetonogestrel.

levonorgestrelreleasingimplant

Tworodlevonorgestrelreleasingimplant,eachrod
containing75mgoflevonorgestrel(150mgtotal).

18.3.5 Intravaginal contraceptives


Progesteronereleasingvaginalringcontaining2.074
gofmicronizedprogesterone.
progesteronevaginalring*
*Foruseinwomenactivelybreastfeedingatleast4
timesperday
18.4 Estrogens
18.5 Insulins and other medicines used for diabetes
Solid oral dosage form: (controlledrelease tablets)
30mg;60mg;
gliclazide*

80mg.
*glibenclamidenotsuitableabove60years.

glucagon

Injection:1 mg/ mL.

insulininjection(soluble)

Injection: 40IU/ mL in10 mLvial;100IU/mL in


10mLvial.

intermediateactinginsulin

Injection: 40IU/ mL in10 mLvial;100IU/mL in


10mLvial(ascompoundinsulinzincsuspensionor
isophaneinsulin).

metformin

Tablet: 500mg(hydrochloride).

ComplementaryList[c]
metformin

Tablet:500mg(hydrochloride).

18.6 Ovulation inducers


ComplementaryList
clomifene

Tablet:50mg(citrate).

18.7 Progestogens
medroxyprogesteroneacetate

Tablet: 5mg.

19th WHO Model List of Essential Medicines (April 2015)

page - 34

EssentialMedicines
WHOModelList

19thedition

18.8 Thyroid hormones and antithyroid medicines


levothyroxine

Tablet: 25micrograms [c];50micrograms;


100micrograms(sodiumsalt).

potassiumiodide

Tablet: 60mg.

propylthiouracil

Tablet: 50mg.

ComplementaryList[c]
Lugolssolution

Oralliquid:about130mgtotaliodine/mL.

potassiumiodide

Tablet:60mg.

propylthiouracil

Tablet:50mg.

19. IMMUNOLOGICALS
19.1 Diagnostic agents
AlltuberculinsshouldcomplywiththeWHOrequirementsfortuberculins.
tuberculin,purifiedproteinderivative(PPD)

Injection.

19.2 Sera and immunoglobulins


AllplasmafractionsshouldcomplywiththeWHOrequirements.
Injection.
Antivenomimmunoglobulin*
*Exacttypetobedefinedlocally.
diphtheriaantitoxin

Injection: 10000IU;20000IUinvial.

19.3 Vaccines
WHO immunization policy recommendations are published in vaccine position papers on the basis of
recommendationsmadebytheStrategicAdvisoryGroupofExpertsonImmunization(SAGE).
WHOvaccinepositionpapersareupdatedthreetofourtimesperyear.Thelistbelowdetailsthevaccines
forwhichthereisarecommendationfromSAGEandacorrespondingWHOpositionpaperasat[DATE].
ThemostrecentversionsoftheWHOpositionpapers,reflectingthecurrentevidencerelatedtoaspecific
vaccineandtherelatedrecommendations,canbeaccessedatanytimeontheWHOwebsiteat:
http://www.who.int/immunization/documents/positionpapers/en/index.html.
Vaccine recommendations may be universal or conditional (e.g., in certain regions, in some highrisk
populationsoraspartofimmunizationprogrammeswithcertaincharacteristics).Detailsareavailablein
the relevant position papers, and in the Summary Tables of WHO Routine Immunization
RecommendationsavailableontheWHOwebsiteat:
http://www.who.int/immunization/policy/immunization_tables/en/index.html.
SelectionofvaccinesfromtheModelListwillneedtobedeterminedbyeachcountryafterconsideration
ofinternationalrecommendations,epidemiologyandnationalpriorities.
AllvaccinesshouldcomplywiththeWHOrequirementsforbiologicalsubstances.
WHOnotedtheneedforvaccinesusedinchildrentobepolyvalent.
Recommendationsforall

BCGvaccine
19th WHO Model List of Essential Medicines (April 2015)

page - 35

EssentialMedicines
WHOModelList

19thedition

diphtheriavaccine
Haemophilusinfluenzaetypebvaccine
hepatitisBvaccine
HPVvaccine
measlesvaccine
pertussisvaccine
pneumococcalvaccine
poliomyelitisvaccine
rotavirusvaccine
rubellavaccine
tetanusvaccine

Recommendationsforcertainregions
Japaneseencephalitisvaccine
yellowfevervaccine
tickborneencephalitisvaccine

Recommendationsforsomehighriskpopulations
choleravaccine
hepatitisAvaccine
meningococcalmeningitisvaccine
rabiesvaccine
typhoidvaccine

Recommendationsforimmunizationprogrammeswithcertaincharacteristics
influenzavaccine(seasonal)
mumpsvaccine
varicellavaccine

20. MUSCLE RELAXANTS (PERIPHERALLY-ACTING) AND CHOLINESTERASE


INHIBITORS
atracurium

Injection: 10mg/ mL (besylate).

19th WHO Model List of Essential Medicines (April 2015)

page - 36

EssentialMedicines
WHOModelList

19thedition

neostigmine

Injection: 500microgramsin1mLampoule;2.5mg
(metilsulfate)in1mLampoule.
Tablet:15mg(bromide).
Injection: 50mg(chloride)/ mLin2mLampoule.

suxamethonium
Powderforinjection(chloride),invial.
vecuronium[c]

Powderforinjection:10mg(bromide)invial.

ComplementaryList
Injection:1mgin1mLampoule.
pyridostigmine
Tablet:60mg(bromide).
vecuronium

Powderforinjection:10mg(bromide)invial.

21. OPHTHALMOLOGICAL PREPARATIONS


21.1 Anti-infective agents
aciclovir

Ointment: 3%W/W.

azithromycin

Solution(eyedrops):1.5%.

gentamicin

Solution(eyedrops):0.3%(sulfate).

ofloxacin

Solution(eyedrops): 0.3%.

tetracycline

Eyeointment: 1%(hydrochloride).

21.2 Anti-inflammatory agents


prednisolone

Solution(eyedrops): 0.5%(sodiumphosphate).

21.3 Local anaesthetics


tetracainea

Solution(eyedrops): 0.5%(hydrochloride).
a

Not in preterm neonates.

21.4 Miotics and antiglaucoma medicines


acetazolamide

Tablet: 250mg.

latanoprost

Solution(eyedrops): latanoprost50micrograms/mL

pilocarpine

Solution(eyedrops): 2%;4%(hydrochloride or
nitrate).

timolol

Solution(eyedrops): 0.25%;0.5%(ashydrogen
maleate).

21.5 Mydriatics
Solution(eyedrops): 0.1%;0.5%;1%(sulfate).
atropine* a

*[c]Orhomatropine(hydrobromide)or
cyclopentolate(hydrochloride).
a

>3 months.

ComplementaryList
19th WHO Model List of Essential Medicines (April 2015)

page - 37

EssentialMedicines
WHOModelList

19thedition

epinephrine(adrenaline)

Solution(eyedrops):2%(ashydrochloride).

21.6 Anti-vascular endothelial growth factor (VEGF) preparations


ComplementaryList
bevacizumab

Injection:25mg/mL.

22. OXYTOCICS AND ANTIOXYTOCICS


22.1 Oxytocics
ergometrine

misoprostol

Injection: 200micrograms(hydrogenmaleate)in1
mLampoule.
Tablet: 200micrograms.
Managementofincompleteabortionand
miscarriage;
Preventionandtreatmentofpostpartum
haemorrhagewhereoxytocinisnotavailable
orcannotbesafelyused
Vaginaltablet:25micrograms.*
*Onlyforuseforinductionoflabourwhere
appropriatefacilitiesareavailable.

oxytocin

Injection: 10IUin1 mL.

ComplementaryList
mifepristone*misoprostol*
Wherepermittedundernationallawand
whereculturallyacceptable.

Tablet200mgtablet200micrograms.
*Requiresclosemedicalsupervision.

22.2 Antioxytocics (tocolytics)


nifedipine

Immediatereleasecapsule:10mg.

23. PERITONEAL DIALYSIS SOLUTION


ComplementaryList
intraperitonealdialysissolution
(ofappropriatecomposition)

Parenteralsolution.

24. MEDICINES FOR MENTAL AND BEHAVIOURAL DISORDERS


24.1 Medicines used in psychotic disorders
Injection: 25mg(hydrochloride)/mLin2mL
ampoule.
chlorpromazine

Oralliquid:25mg(hydrochloride)/5mL.
Tablet:100mg(hydrochloride).

fluphenazine

Injection: 25mg(decanoateorenantate)in1 mL
ampoule.

19th WHO Model List of Essential Medicines (April 2015)

page - 38

EssentialMedicines
WHOModelList

19thedition

haloperidol

Injection: 5mgin1 mL ampoule.


Tablet:2mg;5mg.

risperidone

Solidoraldosageform:0.25mgto6.0mg.

ComplementaryList
Injection:25mg(hydrochloride)/mLin2mLampoule.
chlorpromazine[c]

Oralliquid:25mg(hydrochloride)/5mL.
Tablet:10mg;25mg;50mg;100mg(hydrochloride).

clozapine

Solidoraldosageform:25to200mg.
Injection:5mgin1mLampoule.

haloperidol[c]

Oralliquid:2mg/mL.
Solidoraldosageform:0.5mg;2mg;5mg.

24.2 Medicines used in mood disorders


24.2.1 Medicines used in depressive disorders
amitriptyline

Tablet: 25mg;75mg. (hydrochloride).

fluoxetine

Solidoraldosageform: 20mg(ashydrochloride).

ComplementaryList[c]
fluoxetinea

Solidoraldosageform:20mg(ashydrochloride).
a

>8 years.

24.2.2 Medicines used in bipolar disorders


carbamazepine

Tablet(scored): 100mg;200mg.

lithiumcarbonate

Solidoraldosageform:300mg.

valproicacid(sodiumvalproate)

Tablet(entericcoated): 200mg;500mg(sodium
valproate).

24.3 Medicines for anxiety disorders


diazepam

Tablet(scored): 2mg;5mg.

24.4 Medicines used for obsessive compulsive disorders


clomipramine

Capsule: 10mg;25mg(hydrochloride).

24.5 Medicines for disorders due to psychoactive substance use


Chewinggum:2mg;4mg (aspolacrilex).
nicotinereplacementtherapy(NRT)

Transdermalpatch:5mgto30mg/16hrs;7mgto
21mg/24hrs.

ComplementaryList

19th WHO Model List of Essential Medicines (April 2015)

page - 39

EssentialMedicines
WHOModelList

19thedition

Concentratefororalliquid:5mg/mL;10mg/mL
(hydrochloride).
methadone*

Oralliquid:5mg/5mL;10mg/5mL(hydrochloride).
*Thesquareboxisaddedtoincludebuprenorphine.The
medicinesshouldonlybeusedwithinanestablished
supportprogramme.

25. MEDICINES ACTING ON THE RESPIRATORY TRACT


25.1 Antiasthmatic and medicines for chronic obstructive pulmonary disease
beclometasone

Inhalation(aerosol): 50 micrograms(dipropionate)
perdose;100micrograms(dipropionate)perdose
(asCFCfreeforms).

budesonide[c]

Inhalation(aerosol): 100microgramsperdose;
200microgramsperdose.

epinephrine(adrenaline)

Injection: 1mg(ashydrochlorideorhydrogen
tartrate)in
1mLampoule.

ipratropiumbromide

Inhalation(aerosol):20micrograms/metereddose.
Inhalation(aerosol): 100micrograms(assulfate)per
dose.

salbutamol

Injection: 50 micrograms (as sulfate)/ mL in 5 mL


ampoule.
Metereddoseinhaler(aerosol):100micrograms(as
sulfate)perdose.
Respirator solution for use in nebulizers: 5mg (as
sulfate)/mL.

26. SOLUTIONS CORRECTING WATER, ELECTROLYTE AND ACIDBASE


DISTURBANCES
26.1 Oral
oralrehydrationsalts

Seesection17.5.1.

potassiumchloride

Powderforsolution.

26.2 Parenteral
glucose

Injectablesolution: 5%(isotonic);10%(hypertonic);
50%(hypertonic).
Injectablesolution: 4%glucose,0.18%sodium
chloride
(equivalenttoNa+30mmol/L,Cl30mmol/L).

glucosewithsodiumchloride

Injectablesolution:5%glucose,0.9%sodium
chloride(equivalenttoNa+150mmol/LandCl
150mmol/L);5%glucose,0.45%sodiumchloride
(equivalenttoNa+75mmol/LandCl75mmol/L)
[c].

19th WHO Model List of Essential Medicines (April 2015)

page - 40

EssentialMedicines
WHOModelList

19thedition

Solution: 11.2%in20 mL ampoule


(equivalenttoK+1.5mmol/mL,Cl1.5mmol/mL).
potassiumchloride

sodiumchloride

Solutionfordilution:7.5%(equivalenttoK1mmol/
mLandCl1mmol/mL)[c];15%(equivalenttoK2
mmol/mLandCl2mmol/mL)[c].
Injectablesolution: 0.9%isotonic(equivalenttoNa+
154mmol/L,Cl154mmol/L).
Injectablesolution:1.4%isotonic(equivalenttoNa+
167mmol/L,HCO3167mmol/L).

sodiumhydrogencarbonate
Solution:8.4%in10mLampoule(equivalentto
Na+1000mmol/L,HCO31000mmol/L).
sodiumlactate,compoundsolution

Injectablesolution.

26.3 Miscellaneous
waterforinjection

2mL;5mL;10mLampoules.

27. VITAMINS AND MINERALS


ascorbicacid

Tablet: 50mg.

calcium

Tablet:500mg(elemental).
Oralliquid: 400IU/ mL.

cholecalciferol*[c]

Solidoraldosageform:400IU;1000IU.
*Ergocalciferolcanbeusedasanalternative.

ergocalciferol

Oralliquid: 250micrograms/mL(10000IU/ mL).


Solidoraldosageform:1.25mg(50000IU).
Capsule: 200 mg.

iodine

Iodizedoil:1mL(480mgiodine);0.5mL(240mg
iodine)inampoule(oralorinjectable);0.57mL(308
mgiodine)indispenserbottle.

nicotinamide

Tablet: 50mg.

pyridoxine

Tablet: 25mg(hydrochloride).
Capsule: 50000IU;100 000IU;200000IU(as
palmitate).

retinol

Oraloilysolution:100000IU(aspalmitate)/mLin
multidosedispenser.
Tablet(sugarcoated):10000IU(aspalmitate).
Watermiscibleinjection:100000IU(aspalmitate)
in
2mLampoule.

riboflavin

Tablet: 5mg.

sodiumfluoride

Inanyappropriatetopicalformulation.

19th WHO Model List of Essential Medicines (April 2015)

page - 41

EssentialMedicines
WHOModelList

19thedition

Tablet: 50mg(hydrochloride).

thiamine
ComplementaryList
calciumgluconate

Injection:100mg/mLin10mLampoule.

28. EAR, NOSE AND THROAT MEDICINES [c]


aceticacid

Topical:2%,inalcohol.

budesonide

Nasalspray:100microgramsperdose.

ciprofloxacin

Topical:0.3%drops(ashydrochloride).
Nasalspray: 0.05%.

xylometazolinea

aNot in children less than 3 months.

29. SPECIFIC MEDICINES FOR NEONATAL CARE


29.1 Medicines administered to the neonate [c]

caffeinecitrate

Chlorhexidine

Injection: 20 mg/ mL (equivalent to 10mg caffeine


base/mL).
Oralliquid:20mg/mL(equivalentto10mgcaffeine
base/mL).
Solution or gel: 7.1% (digluconate) delivering 4%
chlorhexidine(forumbilicalcordcare)[c].

ComplementaryList
ibuprofen

Solutionforinjection:5mg/mL.
Solutionforinjection:

prostaglandinE

surfactant

ProstaglandinE1:0.5mg/mLinalcohol.
ProstaglandinE2:1mg/mL.
Suspension for intratracheal instillation: 25mg/mL
or80mg/mL.

29.2 Medicines administered to the mother


dexamethasone

Injection:4mg/ mL dexamethasonephosphate(as
disodiumsalt)

30. MEDICINES FOR DISEASES OF JOINTS


30.1 Medicines used to treat gout
allopurinol

Tablet: 100mg.

30.2 Disease-modifying agents used in rheumatoid disorders (DMARDs)


chloroquine

Tablet: 100mg;150mg(asphosphateorsulfate).

ComplementaryList
azathioprine

Tablet:50mg.

hydroxychloroquine[c]

Solidoraldosageform:200mg(assulfate).

methotrexate

Tablet:2.5mg(assodiumsalt).

19th WHO Model List of Essential Medicines (April 2015)

page - 42

EssentialMedicines
WHOModelList

19thedition

penicillamine

Solidoraldosageform:250mg.

sulfasalazine

Tablet:500mg.

30.3 Juvenile joint diseases


Suppository:50mgto150mg.
acetylsalicylicacid*(acuteor
chronicuse)

Tablet:100mgto500mg.
*Foruseforrheumaticfever,juvenilearthritis,Kawasakidisease.

19th WHO Model List of Essential Medicines (April 2015)

page - 43

Main references

Main references

Australian Medicines Handbook. Adelaide, 2011.


http://www.amh.net.au

British national formulary. British Medical Association and Royal Pharmaceutical Society of
Great Britain, London, 2012.
http://bnf.org

British national formulary for children. British Medical Association and Royal Pharmaceutical
Society of Great Britain, London, 2012.
Vidal dictionary, Paris, 2011.
http://www.vidal.fr

Drugs used in bacterial infections. World Health Organisation, Geneva, 2003.


http://www.who.int/medicines/library/bacterial_model_pres/bacterial_content.shtml
Drugs in pregnancy and lactation. G.G. Briggs and al., Philadelphia, 2002.

Guidelines for Drug Donations. World Health Organisation, Geneva, 2000.

Rpertoire comment des mdicaments. Belgian Centre for Pharmacotherapeutic information,


Brussels, 2011.
http://www.cbip.be
Prescrire. Numerous articles published between 2000 and 2012.
http://www.prescrire.org

Prescrire. Petit manuel de pharmacovigilance et pharmacie clinique. Hors-srie 2011.

Stability of essential drugs in tropical climate. World Health Organisation, Geneva, 1994.
The extra pharmacopoeia. Martindale, London, 2012.

WHO Model Formulary. World Health Organisation, Geneva, 2008.


http://www.who.int/selection_medicines/list/WMF2008.pdf

WHO Model Formulary for Children. World Health Organisation, Geneva, 2010.

WHO model list (17th edition). World Health Organisation, 2011.


http://www.who.int/medicines/publications/essentialmedicines

367

Alphabetical index

Alphabetical index

Abac ........................................................................15
Abacavir (ABC), oral ..............................................15
Abamune ................................................................15
AC Vax .................................................................248
Acetaminophen, injection....................................215
Acetaminophen, oral ............................................116
Acetylsalicylic acid (ASA), oral ............................16
Aciclovir, eye ointment ........................................261
Aciclovir, oral ..........................................................17
Activated charcoal, oral .............................................
Actrapid................................................................196
Adalat....................................................................111
AdalatLA...............................................................111
Adiazine................................................................143
Adrenaline, injection ............................................181
Advil .......................................................................80
Akineton .................................................................33
Albendazole, oral....................................................18
Albuterol, aerosol .................................................137
Albuterol, injection ...............................................223
Albuterol, nebuliser solution ..............................138
Albuterol, oral .......................................................136
Alcohol-based (sol. or gel), external use............262
Aldactone..............................................................140
Aldomet ..................................................................97
Aluminium hydroxide, oral ..................................19
Aluvia .....................................................................93
Ambisome .............................................................159
Amitriptyline, oral..................................................20
Amodiaquine (AQ), oral........................................21
Amoxicillin, injection ...........................................161
Amoxicillin, oral .....................................................22
Amoxicillin/clavulanic acid, injection ..............157
Amoxicillin/clavulanic acid, oral.........................23
Amphotericin B conventional, injection............158
Amphotericin B liposomal, injection .................159
Ampicilline, injection ...........................................161

368

Anafranil ................................................................46
Ancobon..................................................................67
Ancotil ....................................................................67
Antituberculous vaccine ......................................243
Arsobal..................................................................204
Arsumax .................................................................26
Artecospe adult.......................................................28
Artmther, injection............................................162
Artemether/lumefantrine, oral ............................25
Artesun.................................................................163
Artesunate rectal...................................................263
Artesunate (AS), injection....................................163
Artesunate (AS), oral..............................................26
Artesunate/amodiaquine (AS/AQ), oral ...........27
Artesunate + sulfadoxine/pyrimethamine
(AS + SP), oral...................................................28
Ascorbic acid, oral ..................................................29
Aspirin, oral.............................................................16
Atenolol, oral...........................................................30
Atropine, injection ................................................164
Augmentin ......................................................23,157
Aviranz 600 ............................................................58
Avlosulfon ..............................................................50
Avocomb ...............................................................152
Avocomb N ...........................................................153
Azithromycin, oral..................................................31
AZT/3TC, oral ......................................................152
AZT/3TC/NVP, oral............................................153

Bactrim ...................................................................49
BCG vaccine...........................................................243
Beclazone ................................................................32
Beclometasone, aerosol ..........................................32
Becotide...................................................................32
Benadon ................................................................128
Benerva ..........................................................145,228
Benzathine benzylpenicillin, injection...............165

Alphabetical index
Benzoic acid + salicylic acid, external use.........264
Benzyl benzoate, external use.............................265
Benzylpenicillin, injection ...................................166
Benzylpenicillin procaine, injection ...................167
Benzylpenicillin procaine/benzylpenicillin,
injection ...........................................................168
Betadine dermal solution......................................287
Betadine scrub ......................................................288
Betaxin...........................................................145,228
Bicillin ..................................................................168
Biltricide ...............................................................122
Biperiden, oral.........................................................33
Bisacodyl, oral .........................................................34
Bleach .....................................................................268
Brufen .....................................................................80
Buscopan .........................................................79,192
Butylscopolamine, injection ................................192
Butylscopolamine, oral ..........................................79

Cabergoline, oral.........................................................
Calamine, external use.........................................266
Calcium folinate, oral .............................................35
Calcium gluconate, injection...............................169
Calcium hypochlorite (HTH) ..............................268
Camoquin ...............................................................21
Carbamazepine, oral ..............................................36
Cataflam ...............................................................178
Cefalexin, oral .............................................................
Cefixime, oral ..........................................................37
Ceftriaxone, injection ...........................................170
Charcoal (activated), oral...........................................
Chloramphnicol, injection .................................171
Chloramphenicol, oral ...........................................38
Chloramphenicol - long-acting oily, injection ....172
Chlorhexidine, external use ................................267
Chlorinated lime ...................................................268
Chlorine-releasing compounds ..........................268
Chloroquine, oral ....................................................39
Chlorphenamine, oral ............................................41
Chlorpheniramine, oral .........................................41
Chlorpromazine, injection...................................173
Chlorpromazine, oral .............................................42
Cimetidine, oral ......................................................43
Ciplox ...................................................................270

Ciprofloxacin, ear drops ......................................270


Ciprofloxacine, oral ................................................44
Clamoxyl...............................................................161
Clindamycin, injection .........................................174
Clindamycin, oral ...................................................45
Clomipramine, oral ................................................46
Clotrimazole, vaginal tablet ................................271
Cloxacillin, injection .............................................175
Cloxacillin, oral .......................................................47
Cloxapen ..........................................................47,175
Co-amoxiclav, injection ........................................157
Co-amoxiclav, oral ..................................................23
Coarsucam ..............................................................27
Coartem ..................................................................25
Coartemether, oral ..................................................25
Codeine, oral ...........................................................48
Colecalciferol, oral ..................................................60

Combantrin ..........................................................126
Combivir ...............................................................152
Compound sodium lactate, infusion .................238
Condyline .............................................................285
Condylox...............................................................285
Convulex...............................................................150
Coragoxine.......................................................55,179
Cotrimoxazole, oral ................................................49
Crixivan..................................................................81
Crystapen .............................................................166
Cyclokapron..........................................................148
Cysticide ...............................................................122

d4T/3TC/NVP, oral .............................................142


Dalacin ............................................................45,174
Daonil .....................................................................72
Dapsone, oral...........................................................50
Daraprim ..............................................................129
Depakine ...............................................................150
Depocillin .............................................................167
Dermazin..............................................................290
Desogestrel, oral......................................................51
Dexamethasone, injection....................................176
Dexchlorpheniramine, oral ...................................41
Dextrose 5%, infusion ..........................................235
Dextrose 10%, infusion ........................................236
Dextrose 50%, injection ........................................186
369

Alphabetical index
Diazepam, injection..............................................177
Diazepam, oral ........................................................52
Diclofenac, injection .............................................178
Didanosine (ddI), oral ............................................53
Diethizine ...............................................................54
Diethylcarbamazine, oral ......................................54
Digoxin, injection..................................................179
Digoxin, oral ............................................................55
Di-hydan...............................................................120
Dihydroartemisinin/piperaquine
(DHA/PPQ), oral.............................................56
Dilantin ................................................................120
Dinoprostone, external use..................................272
Diphtheria-tetanus-pertussis vaccine (DTP).....244
Dipyrone, injection ...............................................205
Dipyrone, oral .........................................................96
Disulone .................................................................50
Divir .......................................................................53
Doliprane ..............................................................116
Doxycycline, oral ....................................................57
Dulcolax .................................................................34
Duovir ..................................................................152
Duovir N ..............................................................153
Duphalac ................................................................87
Duracillin .............................................................167

Efavir 600 ...............................................................58


Efavirenz (EDV-EFZ), oral.....................................58
Efcortesol ..............................................................191
Eflornithine, injection...........................................180
Egaten...................................................................149
Elavil.......................................................................20
Enalapril, oral ..........................................................59
Epanutin...............................................................120
Epilim ...................................................................150
Epinephrine (EPN), injection ..............................181
Epivir......................................................................88
Ergocalciferol, oral..................................................60
Erythromycin, oral..................................................61
Esidrex ....................................................................78
Eskazole ..................................................................18
Ethambutol (E), oral ...............................................62
Ethanol ...................................................................273
Ethinylestradiol/levonorgestrel, oral ..................63
Ethyl alcohol..........................................................273

370

Etonogestrel, implant ...........................................182


Euglucon ................................................................72
Eurartesim..............................................................56
Exacyl ...................................................................148
Extencilline...........................................................165

Fansidar................................................................144
Fasigyn .................................................................146
Fasinex..................................................................149
Ferrous salts, oral....................................................64
Ferrous salts/folic acid, oral .................................69
Flagyl....................................................................208
Flamazine .............................................................290
Fluconazole, injection...........................................183
Fluconazole, oral.....................................................65
Fluctine...................................................................68
Flucytosine, oral......................................................67
Fluorescein, eye drops..........................................274
Fluoxetine, oral........................................................68
Folic acid, oral .........................................................69
Folinic acid, oral......................................................35
Fortified penicillin procaine, injection...............168
Fortovase...............................................................139
Fosfomycin trometamol, oral ................................70
Frusemide, injection .............................................184
Frusemide, oral .......................................................71
Fulcine ....................................................................74
Fungizone .............................................................258
Furadantin............................................................112
Furosemide, injection ...........................................184
Furosemide, oral .....................................................71

Gardenal ........................................................118,217
Gelofusine .............................................................237
Gentamicin, injection ...........................................185
Gentian violet, external use.................................278
Genticin ................................................................185
Germanin..............................................................227
Glibenclamide, oral ................................................72
Glucose 5%, infusion ............................................235
Glucose 10%, infusion ..........................................236
Glucose 50%, injection .........................................186
Glyceryl trinitrate, oral ..........................................73

Griseofulvin, oral ....................................................74


Grisovin..................................................................74
Gyno-canesten ......................................................271

Haemaccel.............................................................237
Haldol ..............................................................76,187
Halfan .....................................................................75
Halofantrine, oral....................................................75
Haloperidol, injection ..........................................187
Haloperidol, oral.....................................................76
Heparin, injection .................................................188
Hepatitis B vaccine ...............................................245
Hetrazan .................................................................54
Hibitane ................................................................267
Hydralazine, injection..........................................190
Hydrochlorothiazide, oral .....................................78
Hydrocortisone, injection ....................................191
HydroSaluric ..........................................................78
Hyoscine butylbromide, injection ......................192
Hyoscine butylbromide, oral ................................79

Ibuprofen, oral.........................................................80
Imodium .................................................................92
Imogam Rabies .....................................................251
Imovax Rabies.......................................................252
Indinavir (IDV), oral...............................................81
Insulatard .............................................................195
Insulin - general information, injection .............193
Insulin - intermediate-acting, injection..............195
Insulin - long-acting, injection ............................195
Insulin - short-acting, injection ...........................196
Invirase .................................................................139
Iodine (alcoholic solutions), external use ..........275
Iodine tincture, external use................................275
Iodized alcohol, external use...............................275
Iodized oil, oral .......................................................82
Isoniazid (H), oral...................................................83
Isordil......................................................................84
Isosorbide dinitrate, oral........................................84
Itraconazole, oral ....................................................85
Ivermectin, oral .......................................................86

Alphabetical index

Japanese encephalitis vaccine .............................246


Je-Vax....................................................................246

Kaletra ....................................................................93
Kapanol.................................................................104
Kempi....................................................................225
Ketamine, injection ...............................................197

Labetalol, injection......................................................
Labetalol, oral..............................................................
Lactulose, oral .........................................................87
Lamivir ...................................................................88
Lamivudine (3TC), oral..........................................88
Lanoxin............................................................55,179
Largactil...........................................................42,173
Lariam.....................................................................95
Larinate.................................................................163
Laroscorbine............................................................29
Laroxyl....................................................................20
Lasilix ..............................................................71,184
Lasix ................................................................71,184
Levodopa/carbidopa, oral ....................................89
Levonorgestrel, implant.......................................198
Levonorgestrel, oral................................................90
Levonorgestrel (emergency), oral.........................91
Lidocaine, injection...............................................199
Lignocaine, injection ............................................199
Lipiodol ...................................................................82
Loperamide, oral.....................................................92
Lopinavir/ritonavir (LPV/r), oral .......................93
Luminal..........................................................118,217

Magnesium sulfate, injection ..............................200


Malathion, external use........................................276
Malocide ...............................................................129
Manugel ...............................................................262

371

Alphabetical index
Manurub ..............................................................262
Measles vaccine.....................................................247
Mebendazole, oral ..................................................94
Mectizan .................................................................86
Medroxyprogesterone, injection.........................202
Mefloquine (MQ), oral ...........................................95
Melarsoprol, injection ..........................................204
Mencevax AC .......................................................248
Mencevax ACW ...................................................249
Mengivac AC .......................................................248
Meningococcal vaccine A+C ...............................248
Meningococcal vaccine A+C+W135 ..................249
Merbromin, external use......................................277
Mercurochrome.....................................................277
Metamizole, injection ...........................................205
Metamizole, oral .....................................................96
Methyldopa, oral ....................................................97
Methylergometrine, injection..............................206
Methylrosanilinium chloride, external use .......278
Metoclopramide, injection...................................207
Metoclopramide, oral.............................................98
Metronidazole, injection ......................................208
Metronidazole, oral ................................................99
MgSO4, injection...................................................200
Miconazole, cream................................................279
Miconazole, muco-adhesive buccal tablet ........100
Mifepristone (RU486), oral ..................................101
Misoprostol, oral ...................................................102
Modified fluid gelatin, infusion .........................237
Mopral ..................................................................213
Morphine, injection ..............................................209
Morphine immediate-release, oral .....................103
Morphine sustained-release, oral .......................104
Multivitamins, oral ...............................................106
Mupirocin, external use .............................................
Mycostatin.....................................................113,280

NaDCC ............................................................268,291
Nalidixic acid, oral................................................107
Nalone...................................................................210
Naloxone, injection...............................................210
Narcan ..................................................................210
Negram .................................................................107

372

Neravir .................................................................108
Nevimune .............................................................108
Nevirapine (NVP), oral........................................108
Niclosamide, oral..................................................109
Nicotinamide, oral ................................................110
Nifedipine, oral .....................................................111
Nitrofurantoin, oral ..............................................112
Nitroglycerin, oral ..................................................73
Nivaquine ...............................................................39
Nolotil..............................................................96,205
Noramidopyrine, injection ..................................205
Noramidopyrine, oral ............................................96
Norvir ...................................................................135
Notezine..................................................................54
Novalgin ..........................................................96,205
Novesin.................................................................281
Nureflex ..................................................................80
Nystatin, oral .........................................................113
Nystatin, vaginal tablet........................................280

Omeprazole, injection ..........................................213


Omeprazole, oral...................................................114
Oral antipoliomyelitis vaccine (OPV)................250
Oral rehydration salts (ORS), oral ......................115
Orbenin ...........................................................47,175
Ornidyl .................................................................180
Oxybuprocaine, eye drops ..................................281
Oxytocin, injection................................................214

Paluther ................................................................162
Panadol .................................................................115
Pantelmin ...............................................................94
Paracetamol, injection ..........................................215
Paracetamol, oral...................................................116
Paroxetine, oral......................................................117
Penadur ................................................................165
Penicillin G, injection ...........................................166
Penicillin G procaine, injection ...........................167
Penicillin V, oral ....................................................119
Penidural ..............................................................165
Penilevel ...............................................................166

Alphabetical index
Penilivel Retard ....................................................165
Pentacarinat .........................................................216
Pentam..................................................................216
Pentamidine, injection..........................................216
Pentrexyl ..............................................................161
Perfalgan...............................................................215

Perfusalgan...........................................................215
Permethrin 1%, external use ...............................282
Permethrin 5%, external use ...............................283
Phenergan......................................................125,220
Phenobarbital, injection .......................................217
Phenobarbital, oral................................................118
Phenoxymethylpenicillin, oral ............................119
Phenytoin, oral ......................................................120
Phytomenadione, injection..................................218
Pilocarpine, eye drops..........................................284
Piriton.....................................................................41
Plasmion ...............................................................237
Plasmotrim .............................................................26
Podophyllotoxin 0.5%, external use...................285
Podophyllum resin, external use........................286
Polaramine..............................................................41
Polygeline, infusion..............................................237
Polyvidone iodine - aqueous sol.,external use.....287
Polyvidone iodine - scrub sol., external use .....288
Potassium chloride immediate-release, oral...........
Potassium chloride sustained-release, oral.............
Potassium chloride 10%, injection......................219
Potassium permanganate, external use.............289
Povidone iodine - aqueous sol.,
external use .....................................................287
Povidone iodine - scrub sol., external use.........288
Praziquantel, oral..................................................122
Prednisolone, oral .................................................123
Prednisone, oral ....................................................123
Primperan........................................................98,207
Prioderm ...............................................................276
Promethazine, injection .......................................220
Promethazine, oral................................................125
Prosulf ..................................................................221
Protamine, injection..............................................221
Prozac .....................................................................68
Pyrantel, oral .........................................................126
Pyrazinamide (Z), oral .........................................127

Pyridoxine, oral.....................................................128
Pyrimethamine, oral.............................................129
Pyroxin .................................................................128

Quinine, injection..................................................222
Quinine, oral..........................................................130

Rabies immunoglobulin (human) ......................251


Rabies vaccine .......................................................252
Rabipur .................................................................252
Redoxon ..................................................................29
Refolinon.................................................................35
Renitec ....................................................................59
ReSoMal, oral ........................................................131
Retinol, oral ...........................................................132
Retrovir.................................................................151
Riamet.....................................................................25
Rifampicin (R), oral ..............................................133
Ringer lactate, infusion ........................................238
Risordan .................................................................84
Risperdal...............................................................134
Risperidone, oral...................................................134
Ritonavir (RTV), oral ............................................135
Rocephin ...............................................................170

Salbutamol, aerosol ..............................................137


Salbutamol, injection ............................................223
Salbutamol, nebuliser solution ...........................138
Salbutamol, oral ....................................................136
Saquinavir (SQV), oral .........................................139
Seguril .............................................................71,184
Semitard ...............................................................195
Serenace ...........................................................76,187
Sevredol ................................................................103
Sicazine.................................................................290
Silver sulfadiazine, external use .........................290
Sinemet ...................................................................89
Sodium bicarbonate 8.4%, injection ...................224
Sodium chloride 0.9%, infusion..........................239

373

Alphabetical index
Sodium dichloroisocyanurate ......................268,291
Sodium mercurescein, external use....................277
Sodium valproate, oral.........................................150
Solu-cortef ............................................................191
Sorbitrate ................................................................84
Spectinomycin, injection......................................225
Spiroctan...............................................................140
Spironolactone, oral..............................................140
Sporanox.................................................................85
Stanilo...................................................................225
Stavir ....................................................................141
Stavudine (d4T), oral............................................141
Stavudine/lamivudine/nevirapine, oral ..........142
Sterillium..............................................................262
Stocrin ....................................................................58
Streptomycin (S), injection...................................226
Stromectol...............................................................86
Sulfadiazine, oral ..................................................143
Sulfadoxine/pyrimethamine (SP), oral .............144
Sulfamethoxazole/trimethoprim, oral ................49
Sulfamon.................................................................28
Suramin, injection.................................................227
Sustiva....................................................................58
Syntocinon............................................................214

Tagamet...................................................................43
Tegretal ...................................................................36
Tegretol ...................................................................36
Tenormin.................................................................30
Tetanus antitoxin (equine)...................................257
Tetanus immunoglobulin (human) ....................256
Tetanus vaccine (TT).............................................254
Tetracycline, dermal ointment ............................292
Tetracycline, eye ointment...................................293
Thiamine, injection ...............................................228
Thiamine, oral .......................................................145
Tibozole .................................................................100
Tindamax..............................................................146
Tindol....................................................................146
Tinidazole, oral......................................................146
Tramadol, injection ...............................................229
Tramadol, oral .......................................................147

374

Tramal...................................................................229
Tranexamic acid, oral ...........................................148
Tredemine..............................................................109
Triclabendazole, oral ............................................149
Triflucan ..........................................................65,183
Trinitrin, oral ...........................................................73
Triomune...............................................................142
Triptyzol .................................................................20
Triviro ...................................................................142
Trobicin .................................................................225

Ultralente .............................................................195
Ultratard...............................................................195

Valium .............................................................52,177
Valproic acid, oral .................................................150
Velosulin ...............................................................196
Ventolin ..................................................136,137,138
Vermox....................................................................94
Verorab..................................................................252
Videne scrub .........................................................288
Videx.......................................................................53
Viramune ..............................................................108
Vitamin A, oral ......................................................132
Vitamin B complex, oral.......................................106
Vitamin B1, injection ............................................228
Vitamin B1, oral.....................................................145
Vitamin B3, oral.....................................................110
Vitamin B6, oral.....................................................128
Vitamin B9, oral.......................................................69
Vitamin C, oral ........................................................29
Vitamin D2, oral ......................................................60
Vitamin D3, oral ......................................................60
Vitamin PP, oral .....................................................110
Vitamin K1, injection ............................................218
Vitascorbol ..............................................................29
Voltaren ................................................................178
Voltarol .................................................................178

Alphabetical index

Wartec...................................................................285
Wormin...................................................................94

Xylocaine ..............................................................199
Yellow fever vaccine.............................................258
Yomesan................................................................109

Zamadol................................................................229
Zentel......................................................................18
Zerit......................................................................141
Zeritavir ...............................................................141
Ziagen.....................................................................15
Zidovudine (AZT-ZDV), oral..............................151
Zidovudine/lamivudine, oral ............................152
Zidovudine/lamivudine/nevirapine, oral .......153
Zinc oxide, external use .......................................294
Zinc sulfate, oral ...................................................154
Zovirax ............................................................17,261
Zydol.....................................................................229
Zynox ...................................................................210

375

Notes

In the same collection


Clinical guidelines - diagnostic and treatment manual
English, French, Spanish

Obstetrics in remote settings


English, French

Tuberculosis

English, French

Management of a measles epidemic


English, French

Public health engineering in emergency situations


English, French

Rapid health assessment of refugee or displaced populations


English only

Belgium

France

Netherlands

Spain

Switzerland

Mdecins Sans Frontires/Artsen Zonder Grenzen


Rue Duprstraat 94, 1090 Bruxelles/Brussel
Tel.: +32 (0)2 474 74 74
Fax: +32 (0)2 474 75 75
E-mail: info@msf.be
Mdecins Sans Frontires
8 rue Saint-Sabin, 75544 Paris cedex 11
Tel.: +33 (0)1 40 21 29 29
Fax: +33 (0)1 48 06 68 68
Telex: (042) 214360 MSF F
E-mail: office@paris.msf.org
Artsen Zonder Grenzen
Plantage Middenlaan 14, 1018 DD Amsterdam
Tel.: +31 (0)20 52 08 700
Fax: +31 (0)20 62 05 170
Telex: (044) 10773 MSF NL
E-mail: office@amsterdam.msf.org
Medicos Sin Fronteras
Nou de la Rambla 26, 08001 Barcelona
Tel.: +34 933 046 100
Fax: +34 933 046 102
E-mail: oficina@barcelona.msf.org
Mdecins Sans Frontires
78 rue de Lausanne - Case postale 116 - 1211 Genve 27
Tel.: +41 (0)22 849 84 84
Fax: +41 (0)22 849 84 88
Telex: (045) 421 927 MSF CH
E-mail: office-gva@geneva.msf.org

Achev dimprimer en France par ISI, 75020 Paris


Mars 2013