CAUTIONARY STATEMENT

OMEGAXL
Product Information

Experience the Difference!

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Our business is subject to the regulation of two federal agencies, the Federal
Trade Commission (FTC) and the Food and Drug Administration (FDA). These two
agencies are responsible for ensuring that all claims regarding a supplement, such
as Omega XL, are accurate and not misleading. Omega XL is not a drug and
therefore, under no circumstances may an employee of Great HealthWorks state
or imply that Omega XL can treat, cure, prevent or mitigate a disease. Omega XL
is an all-natural product that supports and promotes well being and overall
health. As more fully described below, Omega XL is an Omega 3 essential fatty
acid. Research has shown that Omega 3 essential fatty acids provide numerous
benefits for the human body. As a Customer Care Professional of Great
HealthWorks, you are expected to communicate those benefits to our customers
without stating or implying that Omega XL treats, cures, prevents or mitigates any
disease.
Additionally, many of our customers are on prescription medications. Under no
circumstances should a Customer Care Professional ever recommend or suggest
to a customer that the customer stop taking his or her medication or that by
taking Omega XL, a customer will be able to reduce or stop taking their
medication. All such decisions rest with the customers treating physician and
you should always advise a customer to check with their doctor.
Welcome to Great HealthWorks.

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OMEGA XL
How OmegaXL can improve customers lives!
Omega-3 Essential Fatty Acids and How They Promote Health
Omega-3 fatty acids are a type of polyunsaturated fatty acid that are increasingly believed
to play an important role in promoting good health. Our bodies need Omega-3s for numerous
functions, such as controlling blood clotting and helping build cell membranes in the brain. Our
bodies cannot make Omega-3s, so we must get them through certain types of food like: fish,
walnuts, flaxseeds, beans, and olive oil. Our bodies work their best when the ratios of omega6
and omega3 fatty acids are close to 1 to 1. The western diet that most of our customers grow up
with is very rich in omega 6 fatty acids. Most customers eating a traditional western diet are
consuming a ratio close to 15 to 1 omega6 to omega3 fatty acids. This imbalance has been shown
to contribute to the body producing a damaging inflammatory response.
In our country, most of the beef, chicken, pork, and even fish that we consume is fed with
corn based feed instead of the natural diets they have eaten for hundreds of years. Most farmed
animals are not getting any green plant based food they are meant to eat. Studies have shown that
animals that are not given their proper diet have significantly lower levels of Omega 3s in their
meat. A lot of customers who eat a healthy low fat diet are still not getting a healthy balance of
Omega 6 to Omega 3 fatty acids. Most of the fish our customers eat are farm raised, which
contain a significantly lower amount of Omega 3s. Certain methods of preparing fish can also
affect the Omega 3 content.
The Cell Membrane
The smallest and most important parts of our body, the cells, are surrounded by a cell membrane.
This membrane is composed mainly of fatty acids. The cellular membrane has a vital role in the
cell's life, as it allows nutrients into the cell. In the same manner, it allows the quick removal of
cell waste products. The cell membrane has to have integrity and be flexible to permit these
substance changes. If the cell's membrane loses its integrity, it will not be able to hold water and
nutrients. The cellular membrane allows for communication between cells, keeping body organs
in good shape. If the membrane begins to lose its integrity, the cell will not be able to
communicate with other cells. Scientists believe that one of the factors that favor the rapid
growth of cancerous tumors is the loss of inter-cellular communication. There is a close
relationship between the types of fat we eat and the integrity and fluidity of cell membranes. The
cell membrane is made up of fats. There are two types of fats, the omega 3 fatty acids and the
saturated/hydrogenated fats (like the ones in many fast foods). One of the differences between
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the two types of fats is the way they behave at room temperature: the omega 3 fats are liquid in
these conditions, while the hydrogenated fats are solid. Due to this reason, if you eat foods with
many saturated fats for a long period of time, chances are that your cell membranes will be
harder and will lack fluidity, whereas a diet rich in omega 3 fatty acids will lead to more fluid
cells membranes.
http://www.indepthinfo.com/omega3/function.htm

The key omega3 fatty acids DHA and EPA as well as an array of other essential fatty
acids have been shown to benefit the body in numerous ways and help manage inflammation in
the body. Supplementing diets with omega3 essential fatty acids (DHA and EPA) has been
associated with:
1. Supporting joint health and flexibility
2. Supplementing diets with Omeaga3s has been shown to support joint health in people
with arthritis
3. Reduce risk of cardiovascular disease
a. EPA and DHA have been shown to promote overall health and well-being,
including helping to maintain blood pressure and cholesterol levels in normal
range
b. Omega3s help to promote healthy triglyceride levels
4. Promote heart health
5. Promote joint mobility
6. Supports Brain Health
a. Supports a positive mood
b. Support and promote mood elevation and emotional well-being
7. Supports respiratory health
As with any supplement, we suggest you consult your health care provider as to the
appropriateness of taking Omega XL for your particular health condition.

What is Inflammation
Inflammation is the bodys normal defense mechanism against many adverse medical
conditions such as high blood pressure, clotting of the arteries and joint stiffness. Inflammation is
very important for the body to protect itself. Normally inflammation is self regulating and
resolves itself without causing damage to the body. A lot of conditions involve a damaging
amount of inflammation due to a variety of factors. Scientists have found a link between omega
3 EPA and DHA fatty acid consumption and inflammation. Scientists believe that omega3s DHA
and EPA help the body maintain its natural anti- inflammatory state.

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What is OMEGA XL
Omega XL is made from the New Zealand green lipped mussel sourced from the pristine, pure
waters off the coast of New Zealand. Omega XL has 30 essential fatty acids offering a unique
combination, including DHA and EPA. There is no commercial development in or around these
waters and New Zealand represents some of the most natural and purest waters on Earth. Clean
and unpolluted. The NZGLM is grown in environmentally pristine conditions, in waters
regulated by the New Zealand marine authority. The mussels are harvested after 18 months
limiting the risk of toxin development. Mussels are grown on vines never touching the ocean
floor. The oil used in Omega XL is manufactured using a patented process to maximize the
levels of Omega 3 from the GLM. Research suggests that plant based Omega 3 products, such as
flax seed and ALA products, do not fully convert to DHA and EPA and are not as efficient as
marine based Omega 3 products. New Zealand climate includes high UV rays from the sun due
to the ozone layer being so thin in that part of the world. As a result, the plankton and other
marine life in these waters have developed high levels of antioxidants to survive the high UV.
The plankton are the food for the NZGLM and the mussel acts as a carrier of these high
antioxidants. Once harvested, the mussels are removed from the waters and delivered on barges
within two hours to refrigerated conditions to maintain freshness- our product is controlled from
water to capsule- some products are made from fish that travel great distances on boat before
reaching processing. The mussels are then processed in a clean state of the art facility using the
patented technology to extract the benefits of the GLM and convert it into the oil contained in
Omega XL-.No other Omega 3 product actively marketed in the US today is made using this
patented technology. Over 25 years of research on the oil used in Omega XL has been
undertaken to support that it is a quality Omega 3 supplement that can be used safely, every day
to support good health. Its the same as brushing your teeth- something we do every day.
Green Lipped mussels get their omega 3s directly from plankton. Fish, like salmon,
consume smaller fish or krill that consume the plankton. This is why the Green Lipped Mussel
has such a high Omega 3 content. Fish also can absorb industrial contaminates (like mercury) by
eating smaller fish. Green lipped mussels are grown in some of the cleanest waters in the world.

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The following is a summary of certain diseases and research surrounding

Omega3s. These studies are not intended to suggest that Omega3 fatty acids
can treat or cure these diseases.

Joint Health Associated With Arthritic Conditions

Arthritis effects up to 50 million people in the United States

Arthritis can cause people to suffer from a long list of debilitating side effects

Arthritis is a very debilitating joint disease that affects up to 50 million people, most of them
elderly. This inflammatory disorder affects the joints and adjacent tissues. This inflammation
leads to pain, stiffness, cracking, joint enlargement, causing even more inflammation. This
disease can affect other parts of the body such as muscles, bones, tendons, ligaments, as well as
some internal organs.
Rheumatoid arthritis
Rheumatoid arthritis (RA) is a long-term disease that leads to inflammation of the joints and surrounding
tissues. It can also affect other organs.

Omega XL is an Omega 3 product that supports joint health in people with arthritis.
Omega XL is an Omega 3 product that Improves joint mobility and supports joint
health.

How Omega-3s help

Most clinical studies examining omega-3 fatty acid supplements for arthritis have focused on rheumatoid
arthritis (RA), an autoimmune disease that causes inflammation in the joints. A number of small studies
have found that omega-3s help improve joint pain and morning stiffness.
Laboratory studies suggest that diets rich in omega-3 fatty acids (and low in the inflammatory omega-6
fatty acids) may help people with osteoarthritis, although more study is needed.
Curr Pharm Des. 2009;15(36):4135-48. Omega-3 polyunsaturated fatty acids and immune-mediated
diseases: inflammatory bowel disease and rheumatoid arthritis.
Ruggiero C, Lattanzio F, Lauretani F, Gasperini B, Andres-Lacueva C, Cherubini A.
Berbert AA, Kondo CR, Almendra CL et al. Supplementation of fish oil and olive oil in patients with
rheumatoid arthritis. Nutrition. 2005;21:131-6.

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Goldberg RJ, Katz J. A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid
supplementation for inflammatory joint pain. Pain. 2007 Feb 28; [Epub ahead of print].

Cardiovascular Health
The Food and Drug Administration has determined that there is supportive, but not conclusive,
scientific evidence that suggests a reduction in coronary heart disease as a result of eating foods and
dietary supplements rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) Omega 3
fatty acids.

Heart Issues
High cholesterol Omega 3s Have

High cholesterol affects 42 million Americans, and 63 million more have borderline
high cholesterol

People who follow a Mediterranean-style diet tend to have higher HDL or good cholesterol levels,
which help promote heart health. Inuit Eskimos, who get high amounts of omega-3 fatty acids from eating
fatty fish, also tend to have increased HDL cholesterol and decreased triglycerides (fats in the blood).
Several studies have shown that omega-3 supplements reduce triglyceride levels.
Help your heart get healthy with OmegaXL

J Am Diet Assoc. 2010 Jul;110(7):1018-26. Intake of fish and n-3 fatty acids and future risk of metabolic
syndrome. Baik I, Abbott RD, Curb JD, Shin C.

Department of Foods and Nutrition, College of Natural Sciences, Kookmin University, Seoul, Republic of
Korea.

High blood pressure

The American Heart Association estimates high blood pressure affects

approximately one in three adults in the United States - 73 million people
Everyone can be at risk from high blood pressure
Hypertension is referred to as a "silent killer."

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Several clinical studies suggest that diets or supplements rich in omega-3 fatty acids lower blood pressure
in people with hypertension. An analysis of 17 clinical studies using omega-3 supplements found that
taking them daily may reduce blood pressure in people with untreated hypertension.
Clin Exp Hypertens. 2010 Jan;32(2):137-44. Omega 3 polyunsaturated fatty acids supplementation and
blood pressure levels in hypertriglyceridemic patients with untreated normal-high blood pressure and with
or without metabolic syndrome: a retrospective study. Cicero AF, Derosa G, Di Gregori V, Bove M, Gaddi
AV, Borghi C.

Heart disease

Heart disease accounts for over 20% of the total deaths in the United States
More than 15 million people have some form of the condition in the United States

Coronary heart disease (CHD) is a narrowing of the small blood vessels that supply blood and oxygen to
the heart. CHD is also called coronary artery disease.
Chest pain or discomfort (angina) is the most common symptom. You feel this pain when the heart is not
getting enough blood or oxygen. How bad the pain is varies from person to person.
One of the best ways to help prevent heart disease is to eat a diet low in saturated fat and to eat foods that
are rich in monounsaturated and polyunsaturated fats (including omega-3 fatty acids). Clinical evidence
suggests that EPA and DHA (eicosapentaenoic acid and docosahexaenoic acid, two of the omega-3 fatty
acids found in omegaXL) help reduce risk factors for heart disease, including high cholesterol and high
blood pressure. Omega-3s has been shown to lower levels of triglycerides (fats in the blood), and to
lower risk of death, heart attack, stroke, and abnormal heart rhythms in people who have already had a
heart attack. Omega-3s also appears to help prevent and treat atherosclerosis (hardening of the arteries)
by slowing the development of plaque and blood clots, which can clog arteries.
Large population studies suggest that getting omega-3 fatty acids in the diet, primarily from fish, helps
protect against stroke caused by plaque buildup and blood clots in the arteries that lead to the brain.
Eating at least 2 servings of fish per week can reduce the risk of stroke by as much as 50%.
American Journal of Cardiovascular Drugs:
1 June 2010 - Volume 10 - Issue 3 - pp 165-173
doi: 10.2165/11537270-000000000-00000
Review Articles

Holist Nurs Pract. 2010 Jul-Aug;24(4):223-6. Fish oil supplementation for management of dyslipidemia.
Hessel JA. Sacred Heart Hospital, Eau Claire, WI 54701, USA. joy hessel@yahoo.com

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High Triglyceride

At least 171 million people worldwide suffer from diabetes, or 2.8% of the
population
Diabetes has been described as "America's largest healthcare epidemic."
Diabetes affects more than 20 million Americans. Over 40 million Americans have
prediabetes (early type 2 diabetes).

People with diabetes often have high triglyceride and low HDL levels. Omega-3 fatty acids can help
lower triglycerides and apoproteins (markers of diabetes), and raise HDL, so eating foods or taking
Omega 3s supplements may help people with diabetes.
Cardiol Rev. 2010 Sep-Oct;18(5):258-63. Fish oil for the treatment of cardiovascular disease.

Weitz D, Weintraub H, Fisher E, Schwartzbard AZ. From the Department of Medicine, Leon H. Charney
Division of Cardiology, NYU Langone Medical Center, New York, NY.

Brain Function
High omega-3 consumption has been linked to mental clarity, focus, memory, and more balanced
moods.
Improve your mental focus so you can focus on your life
Psychosom Med. 2010 May;72(4):365-9. Epub 2010 Apr 21. Stress, food, and inflammation:
psychoneuroimmunology and nutrition at the cutting edge. Kiecolt-Glaser JK.

Department of Psychiatry, The Ohio State Institute for Behavioral Medicine Research, The Ohio State
University College of Medicine, Columbus, Ohio 43210-1228, USA. Janice.Kiecolt-Glaser@osumc.edu

Depression

In the United States, around 3.4% of people with major depression commit suicide
Depression is a major cause of morbidity worldwide
In North America the probability of having a major depressive episode within a

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year-long period is 35% for males and 810% for females.

Several studies have found that people who took omega-3 fatty acids in addition to prescription
antidepressants had a greater improvement in symptoms than those who took antidepressants alone.
Another study shows a trend toward superiority of omega-3 supplementation over placebo in reducing
depressive symptoms. However, there was a clear benefit of omega-3 supplementation among patients
with MDE without comorbid anxiety disorders
Depression is a serious illness and you should not try to treat it on your own. See a doctor for help.
Frangou S, Lewis M, McCrone P et al. Efficacy of ethyl-eicosapentaenoic acid in bipolar depression:
randomised double-blind placebo-controlled study. Br J Psychiatry. 2006;188:46-50

J Clin Psychiatry. 2010 Jun 15. [Epub ahead of print] The efficacy of omega-3 supplementation for major
depression: a randomized controlled trial. Lesprance F, Frasure-Smith N, St-Andr E, Turecki G,
Lesprance P, Wisniewski SR. Department of Psychiatry, Centre Hospitalier de l'Universit de Montral,
1560 Sherbrooke E, Montreal, Quebec H2L 4M1, Canada. francois.lesperance@umontreal.ca.

Bipolar disorder

Bipolar disorder has been estimated to afflict more than 5 million Americans
about 1 out of every 45 adults
Bipolar disorder is a condition in which people experience abnormally elevated
and, in many cases, abnormally depressed states for periods of time in a way that
interferes with functioning

In a clinical study of 30 people with bipolar disorder, those who took omega-3s in addition to standard
prescription treatments for bipolar disorder for 4 months experienced fewer mood swings and relapse than
those who received placebo.
Frangou S, Lewis M, McCrone P et al. Efficacy of ethyl-eicosapentaenoic acid in bipolar depression:
randomised double-blind placebo-controlled study. Br J Psychiatry. 2006;188:46-50

Schizophrenia

Schizophrenia is a mental disorder that makes it difficult to tell the difference

between real and unreal experiences, to think logically, to have normal emotional
responses, and to behave normally in social situations

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Preliminary clinical evidence suggests that people with schizophrenia may have an improvement in
symptoms when given omega-3 fatty acids.
Arch Gen Psychiatry. 2010 Feb;67(2):146-54. Long-chain omega-3 fatty acids for indicated prevention of
psychotic disorders: a randomized, placebo-controlled trial. Amminger GP, Schfer MR, Papageorgiou K,
Klier CM, Cotton SM, Harrigan SM, Mackinnon A, McGorry PD, Berger GE. Department of Child and
Adolescent Psychiatry, Medical University of Vienna, Vienna, Austria. gpamminger@gmail.com

Attention deficit/hyperactivity disorder (ADHD)

4.7 percent of American adults are estimated to live with ADHD.

ADHD affecting about 3% to 5% of children globally and diagnosed in about 2% to
16% of school aged children.

Children with attention deficit/hyperactivity disorder (ADHD) may have low levels of certain essential
fatty acids (including EPA and DHA). A clinical study shows that those with lower levels of omega-3
fatty acids had more learning and behavioral problems (such as temper tantrums and sleep disturbances)
than boys with normal omega-3 fatty acid levels.
More research is needed, but eating foods that are high in omega-3 fatty acids is a reasonable approach
for someone with ADHD.
Res Dev Disabil. 2010 May-Jun;31(3):731-42. Epub 2010 Feb 20. Childrens' learning and behaviour and
the association with cheek cell polyunsaturated fatty acid levels. Kirby A, Woodward A, Jackson S, Wang
Y, Crawford MA. The Dyscovery Centre, Allt-yr-yn Campus, University of Wales, Newport NP20 5DA, UK.

Skin disorders
In one clinical study, Twenty-four healthy women aged 40-60 years participated in a single-blind
randomized trial for testing the effect of a proprietary oral supplement for skin nutrition (Eskimo Skin
Care with Omega 3) on skin elasticity, TEWL, and skin roughness. The conclusion was that Eskimo

Skin Care, an oral preparation rich in natural stable fish oil (Omega-3s), can improve skin
elasticity

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J Dermatolog Treat. 2008;19(5):279-83. Supplementation with Eskimo Skin Care improves skin elasticity
in women. A pilot study. Segger D, Matthies A, Saldeen T. Skin Investigation and Technology, Hamburg,
Germany.

Macular Degeneration AMD (a serious age-related eye condition that can progress to blindness)

Macular degeneration can make it difficult or impossible to read or recognize faces

Age-related macular degeneration (AMD), a leading cause of visual loss in older adults, has limited
therapeutic options. A study has shown patients with intermediate risk of AMD or advanced AMD in one
eye should consider taking Omega -3 type supplements. Observational studies have also suggested benefit
from increased dietary intake of macular xanthophylls and omega-3 fatty acids. These are currently being
evaluated prospectively in a randomized controlled clinical trial..
Curr Opin Ophthalmol. 2010 May;21(3):184-9. Nutritional supplements for age-related macular
degeneration. Krishnadev N, Meleth AD, Chew EY. National Eye Institute, National Institutes of Health,
Bethesda, Maryland, USA.

Menstrual pain
Menstrual pain (dysmenorrhea) is one of the main complaints in clinics for women. Dietary
supplementation with polyunsaturated fatty acids (PUFA) has been shown to alleviate the
menstrual pain.
Asia Pac J Clin Nutr. 2008;17 Suppl 1:216-9. Metabolism of omega-6 polyunsaturated fatty acids in
women with dysmenorrhea. Wu CC, Huang MY, Kapoor R, Chen CH, Huang YS. Department of Food
Science and Biotechnology, National Chung Hsing University. 250 Kuo-Kuang Road, Taichung, Taiwan
402.

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Muscle Mass (elderly or even athletes)

Omega-3 fatty acids have a positive effect on the metabolism of muscle proteins. Supplementing
Omega-3s has been shown to reduce the rate of muscle and bone loss during periods of
inactivity. This could be applicable to body-builders and other athletes during breaks in training
or layoffs due to injury, during which muscle loss could be significant. Muscle wasting is also a
factor for arthritis sufferers. Thinning bones render the elderly especially vulnerable to fractures
and the unsteadiness caused by muscle wasting in the legs that leads to falls

Long-chain omega-3 fatty acids regulate bovine whole-body protein metabolism by promoting muscle insulin
signalling to the AktmTORS6K1 pathway and insulin sensitivity
Andre-Anne Gingras1,2, Phillip James White2,3, P. Yvan Chouinard1,2, Pierre Julien3, Teresa A. Davis4, Luce
Dombrowski2,3, Yvon Couture5, Pascal Dubreuil5, Alexandre Myre1,2,Karen Bergeron1,2, Andr Marette2,3 and M.
Carole Thivierge1,2

Am J Physiol Regul Integr Comp Physiol. 2009 Nov;297(5):R1322-31. Epub 2009 Sep 9. Eicosapentaenoic acid
attenuates arthritis-induced muscle wasting acting on atrogin-1 and on myogenic regulatory factors. Castillero
E, Martn AI, Lpez-Menduia M, Villana MA, Lpez-Caldern A. Department of Physiology, Faculty of
Medicine, Complutense University of Madrid, Madrid, Spain.

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Omega XL General Information

As you may know Omega 3s

Promote joint comfort, mobility, and flexibility.

Helps with a positive mood and emotional well-being. Supporting the brain.
Promote heart health reducing the risk of cardiovascular diseases by
o Helping to maintain normal blood pressure.
o Reducing triglyceride levels
o Maintaining a healthy cholesterol range
Helps to promote respiratory health
Helps promote the skin for a more youthful appearance!
Promote a healthy balance between essential fatty acids we dont get from our normal
diet.

Omega XL is the ultimate omega 3 solution.

Omega XL is the only omega 3 supplement endorsed by the NFL alumni association;
helping promote your favorite former players health following there football career.
Omega XL is the only NSF approved Omega 3 product from the pristine waters of New
Zealand, ensuring a product free from contaminants.
Comes from the pristine waters of New Zealand free from pollutants.
o Using strictest quality standards in the world to ensure purity
It is the only Omega 3 supplement using a patented extraction process to create the oil
from the green lipped mussel
Clinical studies are currently being conducted to determine how much more effective
the green lipped mussel is than fish oils. (past studies have shown it to be 200 to 400
times more effective)
Fish oils only have DHA and EPA. Omega XL has DHA and EPA plus another 28 essential
fatty acids.
Omega XL has no known side effects or drug interaction
Omega XL is an easy to swallow small gel capsule. Most fish oils have large hard to
swallow capsules.
Each soft gel capsule contains perna canailiculas oil, pharmaceutical grade olive oil, and
vitamin E.
A large percentage of fish oil supplements come from china without being sourced from
there.

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Our Story
For centuries the ancient Maoris tribe from New Zealand has claimed that consuming
the green-lipped mussels raw helps them maintain good health. Many years ago, researchers
noticed the coastal Maoris had much less disorders than their inland relatives. The only
difference between the coastal and inland Maori, who were suffering from these conditions,
was the diet of the green lipped mussel, the main ingredient in Omega XL.

Customer Directions (on bottle): Take two (2) to six (6) soft gel capsules once per day,
preferably with meals.
(Note: More can be taken if desired.)
Omega XL contains 50mg of Omega Fatty Acids per capsule
(100mg per serving)
OTHER INGREDIENTS: Green Shell Mussel oil extract, Olive oil, and d-alpha
Tocopherol (Vitamin E), Gelatin, Glycerine.
Occasionally we may receive inquires from the customers about reactions relating to
stomach, discomfort, skin rashes, slight nausea, diarrhea, or Headache.
Some customers upon initial use of the product may experience increased discomfort
before experiencing improvement in their well being.

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