Drug

Cyclosporin
Methotrexate
Penicillamine
Tetracycline
(tetracycline,
doxycycline)
Rifampicin
Pancreatin

Ipratropium
Steroids
Omeprazole
Ranitidine
Ciprofloxacin
Desmopressin
Systemic
steroids
Carbamazepine
Ipratropium
Alendronate

Allopurinol

Pharmacology
Immunosuppres
sant
Anti folate
Immunosuppres
sant
Broad-spec
Antibiotic

Uses
Organ transplant, psoriasis, U.C
Autoimmune diseases (psoriasis),
cancer, abortions, sarcoidosis,
Rheumatoid arthritis
RAS not due to HSV (mouthwash),

Dental aspect
+INFX., gingival swelling, xanthelasma,
parasthesiae of lips,
+INFX., ulcers,
Oral pemphigoid lesion, lichenoid, sever ulcers,
taste disturbed
Tetracycline staining, enhance hypoglycaemia
(DM)

Bactericidal
antibiotic
Pancreatic
enzyme
replacement
Anticholinergic

Tuberculosis, leigonaires

Proton pump
inhibitor
H2 receptor
antagonist
Quinolone
Synthetic ADH

GORD, peptic ulcers,

Xerostomia
Steroid cover, INFX., dysphonia (inhaled)
Iron deficiency anemi1a, xerostomia

GOQRD, peptic ulcers

Erythema multiforme

Cystic fibrosis, pancreatic tumours

Asthma

Red saliva, sweat, tears and urine, hepatic

enzyme inducer
Ulcers when held in mouth

GI tract infx., respiratory infx.

vWF disease, Haemophilia A,
diabetes insipidus
Kaposis sarcoma, hairy leukoplakia, candidosis,
oral keritanosis (premalignant)

Anticholinergic
Bisphosphonate
s
Xanthine
oxidase inhibitor

Diabetes insipidus
Asthma
Osteomalacia, pagets,
hyperparathyroidism, osteogenesis
imperfect
Gout

Xerostomia, sedation
BIONJ: pain, exposed bone, bad smelling
discharge, fistula
Oral ulcers
Rashes with penicillin, oral ulcers with penicillin

Anti-TNF

Antimalarials
NSAIDs
Gold
Nicorandil
Phentolamine

Crohns, ankylosing spondylitis,

psoriasis, psoriatic arthritis,
rheumatoid arthritis
RA,
Vasodilator
Alpha blocker

Atenolol,
propanolol

Beta blocker

Ramipril,
enalapril
Losartan,
candesartan

ACEi

Amlodipine,
nifedepine
Furosemide,
hydrochlorothiaz
ide
Digoxin

Angiotensin ll
receptor
blockers
Calcium channel
blocker
Diuretic

RA, pemphigus vulgaris

Angina
Raynauds syndrome, scleroderma,
hypertension
Hypertension, angina, atrial
fibrillation, arrhythmias, congestive
HF, aortic regurgitation, MI
Hypertension, systemic sclerodosis
Hypertension (pt.s intolerable of
ACEi), heart failure (pt.s intolerable
of ACEi)
Hypertension, angina
Hypertension, heart failure, liver
disease, kidney disease

Increases
Atrial fibrillation
contractility of
heart
LP caused by beta bloackers, antimalarials, ACEi, NSAIDS
Erythema multiforme penicillin, codeine
Myxoedema coma (hypothyroidism) precipitated by codeine and sedatives

Increased risk of infx., cancers

Lichenoid
Lichenoid, oral ulcers
Lichenoid, ulceration
Oral ulcers
Xerostomia
Xerostomia, lichenoid, parasthesia

Xerostomia, lichenoid, ulcers, taste disturbance,

angioedema around mouth, persistent cough
Xerostomia, lichenoid, flushing, taste
disturbance, gag reflex
Gingival swelling (particulary with nifedepine),
angioedema, flushing
Xerostomia, lichenoid, , erythema multiforme

Nausea, vomiting, dysrhythmias after tooth

extractions, ECG changes after tooth
extractions