GENERAL OBJECTIVES:
B. SPECIFIC OIBJECTIVES:
The group presenters aim to achieve the following objectives in an hour of case
presentation:
I. PERSONAL DATA:
Name: T.R.C.
Gouty Arthritis
In 2004, while at work in the store in Muntinlupa, patient TRC noted severe right sided
flank pain, with the scale of 5 and is not associated with dysuria, hematuria, fever, chills
and pain and swelling of his knees. He started to drink 1 glass of coconut juice every time
he feels pain but no relief, just helps him to increase his urination
While in 2005, Patient TRC went back to his province still having flank pain with pain
scale of 8 and pain and swelling of his knees. He consulted on a midwife regarding his
pain, and was advised to take Diclofenac 1 tab as needed for pain which he took on and
off (approximately 3 to 4 times a week) for 1 year which relieved the symptoms.
In 2008, patient, still experiencing intermittent right sided flank pain, with the scale of 8
with undocumented fever, dysuria, and pain with swelling and erythema of knees, lateral
and medial malleous, associated with limitation of movement. He also hears thudding
sounds during his urination. He returned to Metro Manila and consulted in Alabang
Medical Center. Ultrasound of Kidneys Ureters and Bladder (KUB) was done revealing
nephrolithiasis on his right kidney. He was then advised by his doctor to undergo removal
of the stone, but was postponed due to pain and swelling of knee. No medications were
prescribed yet.
Last Feb 14, 2010, the patient again developed severe right sided flank pain with pain
scale of 8, radiating to his right leg associated with fever, dysuria, chills noted.
Feb 16, 2010, He consulted again in Alabang Medical Center and urinalysis and CBC
was done. Urinalysis shows hematuria. He was sent home with medication of
Ciprofloxacin 500mg/tab BID, which provided him a relief from symptoms within 4 days
until he again experience the same symptoms.
Feb 18, 2010, He returned to AMC and underwent urinalysis, KUB ultrasound, and CT
sonogram. And from there, he was confined in the said institution for 2 days.
During his confinement, Cysto-RGP bilateral was done, and 1 day after the procedure
patient developed swelling of knees, ankles, with pain in the scale of 8, with limitation of
movement. His doctor referred him to San Juan de Dios Hospital for right urethral stent
application in preparation for Extracorporeal Shockwave Lithotripsy (ESWL).
February 22, 2010, noon he was confined in San Juan De Dios Hospital.
Unrecalled history of immunizations except for “flu vaccines”. He had measles during his
childhood. (Age is unrecalled)
V. PSYCHOSOCIAL HISTORY
Patient RT is married with seven children
He smokes since he was 20 years old. Consuming 5 rolls of tobacco per day for
about 40 years, but claimed to have quit one week prior to admission.
Nephrolithiasis
Nephrolithiasis, the process of forming a kidney stone, a stone in the kidney (or lower
down in the urinary tract). Kidney stones are a common cause of blood in the urine and pain in
the abdomen, flank, or groin. Kidney stones occur in 1 in 20 people at some time in their life.
Kidney stones typically leave the body by passage in the urine stream, and many stones are
formed and passed without causing symptoms. If stones grow to sufficient size before passage on
the order of at least 2-3—millimeters they can cause obstruction of the ureter. The resulting
obstruction causes dilation or stretching of the upper ureter and renal pelvis (the part of the
kidney where the urine collects before entering the ureter) as well as muscle spasm of the ureter,
trying to move the stone. This leads to pain, most commonly felt in the flank, lower abdomen
and groin (a condition called renal colic). Renal colic can be associated
with nausea and vomiting. There can be blood in the urine, visible with the naked eye or under
the microscope (macroscopic ormicroscopic hematuria) due to damage to the lining of the
urinary tract.
There are several types of kidney stones based on the type of crystals of which they consist. The
majority are calcium oxalate stones, followed by calcium phosphate stones. More
rarely, struvitestones are produced by urea-splitting bacteria in people with urinary tract
infections, and people with certain metabolic abnormalities may produce uric acid stones
or cystine stones.
Age
Risk factors:
2. Cystine stones - are due to cystinuria, an inherited (genetic) disorder of the transport of an
amino acid (a building block of protein) called cystine that results in an excess of cystine in the
urine (cystinuria) and the formation of cystine stones. Cystinuria is the most common defect in
the transport of an amino acid. Although cystine is not the only overly excreted amino acid in
cystinuria, it is the least soluble of all naturally occurring amino acids. Cystine tends to
precipitate out of urine and form stones (calculi) in the urinary tract. Small stones are passed in
the urine. However, big stones remain in the kidney (nephrolithiasis) impairing the outflow of
urine while medium-size stones make their way from the kidney into the ureter and lodge there
further blocking the flow of urine (urinary obstruction).
3.Urate stones (uric acid)- About 5–10% of all stones are formed from uric acid Uric acid stones
form in association with conditions that cause hyperuricosuria with or without high blood
serum uric acid levels (hyperuricemia); and with acid/base metabolism disorders where the urine
is excessively acidic (low pH) resulting in uric acid precipitation
4. Struvite stones - also known as infection stones, urease or triple-phosphate stones. About 10–
15% of urinary calculi consist of struvite stones. The formation of struvite stones is associated
with the presence of urea-splitting bacteria,most commonly Proteus mirabilis (but
alsoKlebsiella, Serratia, Providencia species). These organisms are capable of splitting urea
intoammonia, decreasing the acidity of the urine and resulting in favorable conditions for the
formation of struvite stones. Struvite stones are always associated with urinary tract infections
Staghorn calculus
renal stone that develops in the pelvicaliceal system, and in advanced cases has a branching
configuration which resembles the antlers of a stag. Staghorn calculi are composed of
magnesium ammonium phosphate (struvite), which forms in urine that has an abnormally high
pH (above 7.2). This high pH usually develops because of recurrent urinary tract infection with
microorganisms such as Proteus mirabilis.
Radiographically, struvite stones are of relatively low density, but may have a laminated
appearance when combined with calcium salts. Low density struvite stones may not be
appreciated on plain radiographs, but can be readily detected by Ultrasound or CT. Intravenous
urography or retrograde pyelography may also be used to demonstrate the typical branching
appearance of staghorn calculi.
Anatomy and Physiology
The human renal system is made up of two kidneys, two ureters, the urinary
bladder, and the urethra. In addition to the production of urine the renal system
has many other functions.
One quarter to one fifth of cardiac output passes through the kidneys at all times.
This means that the kidneys filter approximately 1.2 liters of blood every minute.
It is therefore not surprising that even slight abnormalities of renal function
quickly lead to electrolyte disturbances. If untreated death will occur.
Kidneys
The paired kidneys are situated on either side of the spinal column, behind the
peritoneal cavity. The right kidney is slightly lower than the left due to the position of the liver.
They are the primary regulators of fluid and acid base-balance in the body. In the average adult,
1,200 ml of blood or about 21% cardiac output passes through the kidneys every minute.
From Bowman’s capsule, the filtrate moves into the tubule of the nephron. In the
proximal convoluted tubule, most of the water and electrolytes are reabsorbed. Solutes such as
glucose are reabsorbed in the loop of Henle, but in the same area, other substances are secreted
into the filtrate, concentrating the urine. In the distal convoluted tubule, additional water and
sodium are reabsorbed under the control of hormones such as antidiuretic hormone(ADH) and
aldosterone. This controlled reabsorption allows fine regulation of fluid and electrolyte balance
in the body. When fluid intake is low or the concentration of the solutes in blood is high, ADH is
released from the anterior pituitary, more water is reabsorbed in the distal tubule, and less urine
is excreted. By contrast, when fluid intake is high or blood solute concentration is low, ADH is
suppressed. Without ADH, the distal tubule becomes impermeable to water, and more urine is
excreted. Aldosterone also affects the tubule. When aldosterone is released from the adrenal
cortex, sodium and water are reabsorbed in greater quantities, increasing the blood volume and
decreasing urinary output.
Nephron
The kidneys receive their oxygenated blood supply from the renal arteries which
come off the abdominal portion of the aorta. Venous blood from the kidneys
drains into the renal veins to join the abdominal portion of the inferior vena cava.
The hilum of the kidneys is located toward the smaller curvature. The opening in
the hilum allows for the entry and exit of blood vessels and nerves. The funnel
shaped extension of the kidneys is called the renal pelvis and it connects the
kidneys to the two ureters. This structure facilitates the collection of the urine
from the kidneys and drainage to the urinary bladder.
The functional parts of the kidneys are divided into two distinct regions. The outer region is
reddish brown in color and is called the renal cortex. This is where the nephrons of the kidney
are located. The inner layer of the kidney is more pinkish
in color and is called the renal medulla. The renal cortex houses the functional
units of the kidneys called nephrons. The inner area of the kidneys is supplied by
a small blood vessel network called the vasa recta.
Ureters
Once the urine is formed in the kidneys, it moves through the collecting ducts into the calyces of
the renal pelvis and from there into the ureters. The ureters are 25 to 30 cm(10-12 in) long in
adult and about 1.25 cm(0.5 in) in diameter. The upper end of each ureter is funnel shaped as it
enters the kidney. The lower ends of the ureters enter the bladder at the posterior corners of the
floor and the bladder. At the junction between the ureter and the bladder, a flaplike fold of
mucous membrane acts as a valve to prevent reflux(backflow) of urine up the ureters.
Bladder
The urinary bladder(vesicle) is a hollow, muscular organ that serves as a reservoir for urine and
as the organ of excretion. When empty, it lies behind the symphysis pubis. In men, the bladder
lies in front of the rectum and above the prostate gland, while in women, it lies in front of the
uterus and vagina.
The smooth muscle layers are collectively called detrusor muscles. It allows the bladder to
expand as it fills with urine and to contract to release urine to the outside of the body during
voiding. The trigone is the base of the bladder which is a triangular area marked by the ureter
openings at the posterior corners and the opening of the urethra at the anterior inferior corner.
Urethra
The urethra extends from the bladder to the urinary meatus(opening). In the adult woman, the
urethra lies directly behind the symphysis pubis, anterior to the vagina, and is between 3-4
cm(1.5 in) long. The urethra serves as passageway for the elimination of urine. The urinary
meatus is located between the labia minora, in front of the vagina and below the clitoris. The
male urethrea is approximately 20 cm(8 in) long and serves as a passageway for semen as well as
the urine. The meatus is located at the distal end of the penis.
In both men and women, the urethra has a mucous membrane lining that is continuous with the
bladder and the ureters. Thus, infection of the urethra can extend through the urinary tract in the
kidneys.
Pelvic floor
The urethra and rectum pass through the pelvic floor which consists of sheets of muscles and
ligaments that provide support to the viscera of the pelvis. The internal sphincter muscle situated
in the proximal urethra and the bladder neck is composed of smooth muscle under involuntary
control. It provides active tension designed to close the urethral lumen. The external sphincter
muscle is composed of skeletal muscle under voluntary control, allowing the individual to
choose when urine is eliminated.
Urination
Micturition, voiding or urination all refer to the process of emptying the urinary
bladder. Urine collects in the bladder until pressure stimulates special sensory nerve endings in
the bladder wall called stretch receptors. This occurs when adult bladder contains between 250
and 450ml of urine.
The stretch receptors transmit impulses to the spinal cord, specifically to the voiding
reflex center located at the level of 2nd to 4th sacral vertebrae, causing the internal sphincter to
relax and stimulating the urge to void. If the time and place are appropriate for urination, the
conscious portion of the brain relaxes the external urethral sphincter muscle and urination takes
place. If the time and place are inappropriate, the micturition reflex usually subsides until the
bladder becomes more filled and the reflex is stimulated again.
Voluntary control of urination is possible only if the nerves supplying the bladder
and urethra, the neural tracts of the cord and brain, and the motor area of the cerebrum are intact.
The individual must be able to sense that the bladder is full.
X. TREATMENT & MANAGEMENT
1. SURGICAL MANAGEMENT
February 23,2010
A retrograde pyelogram is a type of x-ray that allows visualization of the bladder, ureters, and
renal pelvis. Generally, this test is performed during a procedure called cystoscopy - evaluation
of the bladder with an endoscope (a long, flexible lighted tube). During a cystoscopy, contrast
dye, which helps enhance the x-ray images, can be introduced into the ureters via a catheter.
February 26,2010
ARTHROCENTESIS
- Joint aspiration, a procedure whereby a sterile needle and syringe are used to drain
fluid from a joint..
- Joint fluid is typically sent for examination to the lab to determine the cause of the joint
swelling, such as infection, gout, and rheumatoid arthritis.
Extracorporeal shock wave lithotripsy (ESWL) uses shock waves to break a kidney stone into
small pieces that can more easily travel through the urinary tract and pass from the body.
Complications of ESWL include:
Pain caused by the passage of stone fragments.
Urinary tract infection.
DOUBLE J STENT
Is a thin tube inserted to the ureter to prevent or treat obstruction of the urine flow from the
kidney. Double J Stent have multiple perforations to allow the urine to drain from the kidney
down the ureter to the bladder. They may be placed to bypass a stone, relieve obstruction, or to
keep the ureter from swelling shut after a cystoscopicureteroscopic procedure.